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Search of human proteins with 4758194
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758194 serine/threonine kinase 17B [Homo sapiens]
(372 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758194 serine/threonine kinase 17B [Homo sapiens] 749 0.0
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 375 e-104
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 259 4e-69
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 253 1e-67
gi|14670383 death-associated kinase 2 [Homo sapiens] 249 2e-66
gi|167466233 myosin light chain kinase family, member 4 [Homo sa... 200 1e-51
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 197 1e-50
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 197 1e-50
gi|14993776 skeletal myosin light chain kinase [Homo sapiens] 197 1e-50
gi|146219832 myosin light chain kinase 3 [Homo sapiens] 191 7e-49
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 189 3e-48
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 189 3e-48
gi|110349719 titin isoform N2-A [Homo sapiens] 182 3e-46
gi|110349717 titin isoform novex-2 [Homo sapiens] 182 3e-46
gi|110349713 titin isoform novex-1 [Homo sapiens] 182 3e-46
gi|110349715 titin isoform N2-B [Homo sapiens] 182 3e-46
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 181 7e-46
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 169 5e-42
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 169 5e-42
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 169 5e-42
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 169 5e-42
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 169 5e-42
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 169 5e-42
gi|27901803 protein serine kinase H1 [Homo sapiens] 168 6e-42
gi|157785645 SPEG complex locus [Homo sapiens] 168 6e-42
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 168 8e-42
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 168 8e-42
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 168 8e-42
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 168 8e-42
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 168 8e-42
>gi|4758194 serine/threonine kinase 17B [Homo sapiens]
Length = 372
Score = 749 bits (1934), Expect = 0.0
Identities = 372/372 (100%), Positives = 372/372 (100%)
Query: 1 MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYA 60
MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYA
Sbjct: 1 MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYA 60
Query: 61 AKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFS 120
AKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFS
Sbjct: 61 AKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFS 120
Query: 121 LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDF 180
LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDF
Sbjct: 121 LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDF 180
Query: 181 GMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDN 240
GMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDN
Sbjct: 181 GMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDN 240
Query: 241 QETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFEN 300
QETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFEN
Sbjct: 241 QETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFEN 300
Query: 301 LFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSL 360
LFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSL
Sbjct: 301 LFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSL 360
Query: 361 PNPHELVSDLLC 372
PNPHELVSDLLC
Sbjct: 361 PNPHELVSDLLC 372
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 375 bits (963), Expect = e-104
Identities = 200/365 (54%), Positives = 256/365 (70%), Gaps = 18/365 (4%)
Query: 13 GLLTTTPQIPIKMENFNNFYILT-SKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQ 71
GLLT + ++ E F + Y L +ELGRGKFAVVR+CI K +G+E+AAKF++KRR+GQ
Sbjct: 41 GLLTEIRAV-VRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQ 99
Query: 72 DCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVS 131
DCR EI+HEIAVLELA+ P VINLHEVYE SE+IL+LEYAAGGEIF C+ + E
Sbjct: 100 DCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFK 159
Query: 132 ENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE 191
E DV RL++QILEGV++LH ++VHLDLKPQNILL+S PLGDIKIVDFG+SR + ++ E
Sbjct: 160 EKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEE 219
Query: 192 LREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVN 251
LREIMGTPEY+APEIL+YDPI+ ATDMW+IG++ Y++LT SPF+G D QET+LNISQ+N
Sbjct: 220 LREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMN 279
Query: 252 VDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDF-ENLFHPEET--S 308
+ YSEE F +S+ A DFI++LLVK PE R TAE CL H WL Q E F E+
Sbjct: 280 LSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEE 339
Query: 309 SSSQTQDHSVRSSEDKTSKSS-------------CNGTCGDREDKENIPEDSSMVSKRFR 355
+++ + HSV T KS + T G E + +SKRF+
Sbjct: 340 ANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFK 399
Query: 356 FDDSL 360
F++ L
Sbjct: 400 FEEPL 404
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 259 bits (661), Expect = 4e-69
Identities = 136/279 (48%), Positives = 188/279 (67%), Gaps = 9/279 (3%)
Query: 24 KMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR----RGQDCRAEILH 79
+ EN +++Y T +ELG G+FAVV++C KSTG +YAAKF+KKRR R R +I
Sbjct: 5 RQENVDDYYD-TGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIER 63
Query: 80 EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 139
E+++L+ + P VI LHEVYEN +++ILILE AGGE+F + E ++E + +
Sbjct: 64 EVSILKEIQH-PNVITLHEVYENKTDVILILELVAGGELFDFLAEK--ESLTEEEATEFL 120
Query: 140 KQILEGVYYLHQNNIVHLDLKPQNI-LLSSIYPLGDIKIVDFGMSRKIGHACELREIMGT 198
KQIL GVYYLH I H DLKP+NI LL P IKI+DFG++ KI E + I GT
Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180
Query: 199 PEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEET 258
PE++APEI+NY+P+ DMW+IG+I Y+LL+ SPF+G+ QET N+S VN ++ +E
Sbjct: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY 240
Query: 259 FSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWD 297
FS+ S LA DFI+ LLVK+P+KR T + L H W++ D
Sbjct: 241 FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKD 279
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 253 bits (647), Expect = 1e-67
Identities = 129/276 (46%), Positives = 186/276 (67%), Gaps = 9/276 (3%)
Query: 24 KMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQD----CRAEILH 79
+ E+ + Y + +ELG G+FA+VR+C K TG+EYAAKF+KKRR R EI
Sbjct: 5 RQEDVEDHYEM-GEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIER 63
Query: 80 EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 139
E+ +L + P +I LH+++EN ++++LILE +GGE+F + E ++E++ + +
Sbjct: 64 EVNILREIRH-PNIITLHDIFENKTDVVLILELVSGGELFDFLAEK--ESLTEDEATQFL 120
Query: 140 KQILEGVYYLHQNNIVHLDLKPQNI-LLSSIYPLGDIKIVDFGMSRKIGHACELREIMGT 198
KQIL+GV+YLH I H DLKP+NI LL P IK++DFG++ KI E + I GT
Sbjct: 121 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 180
Query: 199 PEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEET 258
PE++APEI+NY+P+ DMW+IG+I Y+LL+ SPF+GE QET NIS VN D+ EE
Sbjct: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 240
Query: 259 FSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294
FS+ S+LA DFI+ LLVK+P++R T L HSW++
Sbjct: 241 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 249 bits (637), Expect = 2e-66
Identities = 133/282 (47%), Positives = 182/282 (64%), Gaps = 11/282 (3%)
Query: 22 PIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKR-----RRGQDCRAE 76
P K + +FY + +ELG G+FA+V++C KSTG EYAAKF+KKR RRG R E
Sbjct: 13 PFKQQKVEDFYDI-GEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVS-REE 70
Query: 77 ILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVI 136
I E+++L VI LH+VYEN ++++LILE +GGE+F + E +SE +
Sbjct: 71 IEREVSILRQVLH-HNVITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEAT 127
Query: 137 RLIKQILEGVYYLHQNNIVHLDLKPQNI-LLSSIYPLGDIKIVDFGMSRKIGHACELREI 195
IKQIL+GV YLH I H DLKP+NI LL P+ IK++DFG++ +I E + I
Sbjct: 128 SFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNI 187
Query: 196 MGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYS 255
GTPE++APEI+NY+P+ DMW+IG+I Y+LL+ SPF+G+ QET NI+ V+ D+
Sbjct: 188 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFD 247
Query: 256 EETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWD 297
EE FS S+LA DFI+ LLVK KR T + L H W+ D
Sbjct: 248 EEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVD 289
>gi|167466233 myosin light chain kinase family, member 4 [Homo
sapiens]
Length = 388
Score = 200 bits (509), Expect = 1e-51
Identities = 112/297 (37%), Positives = 177/297 (59%), Gaps = 7/297 (2%)
Query: 21 IPIKMENFNNFYILTSKE-LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILH 79
+ K N+FY ++ E LG G+F V +C +TG + AAK +K R G + E+ +
Sbjct: 93 VTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTR--GMKDKEEVKN 150
Query: 80 EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 139
EI+V+ +I L++ +E+ ++I+L++EY GGE+F + E + +E D I +
Sbjct: 151 EISVMNQLDHA-NLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNL-TELDTILFM 208
Query: 140 KQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTP 199
KQI EG+ ++HQ I+HLDLKP+NIL + IKI+DFG++R+ +L+ GTP
Sbjct: 209 KQICEGIRHMHQMYILHLDLKPENILCVN-RDAKQIKIIDFGLARRYKPREKLKVNFGTP 267
Query: 200 EYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETF 259
E+LAPE++NYD ++ TDMW++G+IAYMLL+ SPF+G+++ ET NI D +E F
Sbjct: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
Query: 260 SSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSS-SSQTQD 315
+S+ A +FI LL+K R +A L H WL + + ++ + S QD
Sbjct: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQKKKNRGSDAQD 384
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 197 bits (502), Expect = 1e-50
Identities = 103/277 (37%), Positives = 174/277 (62%), Gaps = 9/277 (3%)
Query: 26 ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLE 85
+ ++FY + + LG GKF V + + K T + +A KF K + + I EI+++
Sbjct: 1458 QKVSDFYDIEER-LGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKE--KENIRQEISIMN 1514
Query: 86 LAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEG 145
P+++ + +E + I+++LE +GGE+F + E E+ +E + I+ ++QI EG
Sbjct: 1515 CLHH-PKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFEL-TERECIKYMRQISEG 1572
Query: 146 VYYLHQNNIVHLDLKPQNILLSSIYPLGD-IKIVDFGMSRKIGHACELREIMGTPEYLAP 204
V Y+H+ IVHLDLKP+NI+ + G IK++DFG++R++ +A L+ + GTPE++AP
Sbjct: 1573 VEYIHKQGIVHLDLKPENIMC--VNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAP 1630
Query: 205 EILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQ 264
E++NY+PI ATDMW+IG+I Y+L++ SPF+G+++ ET N++ D+ +E F +S
Sbjct: 1631 EVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISD 1690
Query: 265 LATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENL 301
A DFI +LL K+ + R CL H WL + D +N+
Sbjct: 1691 DAKDFISNLLKKDMKNRLDCTQCLQHPWLMK-DTKNM 1726
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 197 bits (502), Expect = 1e-50
Identities = 103/277 (37%), Positives = 174/277 (62%), Gaps = 9/277 (3%)
Query: 26 ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLE 85
+ ++FY + + LG GKF V + + K T + +A KF K + + I EI+++
Sbjct: 1389 QKVSDFYDIEER-LGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKE--KENIRQEISIMN 1445
Query: 86 LAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEG 145
P+++ + +E + I+++LE +GGE+F + E E+ +E + I+ ++QI EG
Sbjct: 1446 CLHH-PKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFEL-TERECIKYMRQISEG 1503
Query: 146 VYYLHQNNIVHLDLKPQNILLSSIYPLGD-IKIVDFGMSRKIGHACELREIMGTPEYLAP 204
V Y+H+ IVHLDLKP+NI+ + G IK++DFG++R++ +A L+ + GTPE++AP
Sbjct: 1504 VEYIHKQGIVHLDLKPENIMC--VNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAP 1561
Query: 205 EILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQ 264
E++NY+PI ATDMW+IG+I Y+L++ SPF+G+++ ET N++ D+ +E F +S
Sbjct: 1562 EVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISD 1621
Query: 265 LATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENL 301
A DFI +LL K+ + R CL H WL + D +N+
Sbjct: 1622 DAKDFISNLLKKDMKNRLDCTQCLQHPWLMK-DTKNM 1657
>gi|14993776 skeletal myosin light chain kinase [Homo sapiens]
Length = 596
Score = 197 bits (501), Expect = 1e-50
Identities = 108/275 (39%), Positives = 170/275 (61%), Gaps = 8/275 (2%)
Query: 21 IPIKMENFNNFYILTSKE-LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILH 79
+ ++ N ++ + + SKE LG GKF V C+ K+TG + AAK +KK+ + +L
Sbjct: 272 VELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD--KEMVLL 329
Query: 80 EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 139
EI V+ +I L+ E EI+L +EY GGE+F + E + +E D + +
Sbjct: 330 EIEVMNQLNH-RNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHL-TEVDTMVFV 387
Query: 140 KQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGD-IKIVDFGMSRKIGHACELREIMGT 198
+QI +G+ ++H+ ++HLDLKP+NIL + G +KI+DFG++R+ +L+ GT
Sbjct: 388 RQICDGILFMHKMRVLHLDLKPENILC--VNTTGHLVKIIDFGLARRYNPNEKLKVNFGT 445
Query: 199 PEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEET 258
PE+L+PE++NYD I+ TDMW++G+I YMLL+ SPF+G+D+ ET N+ N + EET
Sbjct: 446 PEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEET 505
Query: 259 FSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWL 293
F +VS A DF+ +L+VK+ R A CL+H WL
Sbjct: 506 FEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL 540
>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
Length = 819
Score = 191 bits (486), Expect = 7e-49
Identities = 106/256 (41%), Positives = 157/256 (61%), Gaps = 7/256 (2%)
Query: 39 LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHE 98
LG G+F V +C KSTG AAK +K + R ++ +EI ++ S +I L++
Sbjct: 521 LGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD--REDVKNEINIMNQL-SHVNLIQLYD 577
Query: 99 VYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLD 158
+E+ L++EY GGE+F E + +E DV+ +QI EGV+YLHQ+ I+HLD
Sbjct: 578 AFESKHSCTLVMEYVDGGELFDRITDEKYHL-TELDVVLFTRQICEGVHYLHQHYILHLD 636
Query: 159 LKPQNILLSSIYPLG-DIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATD 217
LKP+NIL + G IKI+DFG++R+ +L+ GTPE+LAPE++NY+ ++ TD
Sbjct: 637 LKPENILC--VNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTD 694
Query: 218 MWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKN 277
MW++G+I YMLL+ SPF+GE + ET I + D+ +TF +S+ A DF+ LLVK
Sbjct: 695 MWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKE 754
Query: 278 PEKRPTAEICLSHSWL 293
R +A CL H WL
Sbjct: 755 KSCRMSATQCLKHEWL 770
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 189 bits (481), Expect = 3e-48
Identities = 95/269 (35%), Positives = 163/269 (60%), Gaps = 7/269 (2%)
Query: 26 ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLE 85
ENF++ Y + E+GRG+F++V++CI K+T ++ A KF+ K+ + ++ A HE A+L+
Sbjct: 2678 ENFDSAYTELN-EIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAA---HEAALLQ 2733
Query: 86 LAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEG 145
+ P+ I LH+ YE+ + ILILE G + + + + E V I+ I+E
Sbjct: 2734 HLQH-PQYITLHDTYESPTSYILILELMDDGRLLDYLMNH--DELMEEKVAFYIRDIMEA 2790
Query: 146 VYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE 205
+ YLH + HLD+KP+N+L+ P+ +K++D + +I + ++G PE+ APE
Sbjct: 2791 LQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPE 2850
Query: 206 ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQL 265
++ P++ TD+W+IG++ Y++L+ SPF+ E +ET +N+ +V+ + E F VS
Sbjct: 2851 VIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNA 2910
Query: 266 ATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294
A DFI +L ++ +RPTA CL H WLQ
Sbjct: 2911 ARDFINVILQEDFRRRPTAATCLQHPWLQ 2939
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 189 bits (481), Expect = 3e-48
Identities = 95/269 (35%), Positives = 163/269 (60%), Gaps = 7/269 (2%)
Query: 26 ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLE 85
ENF++ Y + E+GRG+F++V++CI K+T ++ A KF+ K+ + ++ A HE A+L+
Sbjct: 981 ENFDSAYTELN-EIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAA---HEAALLQ 1036
Query: 86 LAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEG 145
+ P+ I LH+ YE+ + ILILE G + + + + E V I+ I+E
Sbjct: 1037 HLQH-PQYITLHDTYESPTSYILILELMDDGRLLDYLMNH--DELMEEKVAFYIRDIMEA 1093
Query: 146 VYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE 205
+ YLH + HLD+KP+N+L+ P+ +K++D + +I + ++G PE+ APE
Sbjct: 1094 LQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPE 1153
Query: 206 ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQL 265
++ P++ TD+W+IG++ Y++L+ SPF+ E +ET +N+ +V+ + E F VS
Sbjct: 1154 VIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNA 1213
Query: 266 ATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294
A DFI +L ++ +RPTA CL H WLQ
Sbjct: 1214 ARDFINVILQEDFRRRPTAATCLQHPWLQ 1242
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 182 bits (463), Expect = 3e-46
Identities = 91/262 (34%), Positives = 157/262 (59%), Gaps = 6/262 (2%)
Query: 34 LTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRV 93
+ +++LGRG+F +V +C+ S+ + Y AKF+K + Q + EI++L +A+ +
Sbjct: 31252 MIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQ---VLVKKEISILNIARH-RNI 31307
Query: 94 INLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN 153
++LHE +E+ E+++I E+ +G +IF E+ +E +++ + Q+ E + +LH +N
Sbjct: 31308 LHLHESFESMEELVMIFEFISGLDIFERINTSAFEL-NEREIVSYVHQVCEALQFLHSHN 31366
Query: 154 IVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPIT 213
I H D++P+NI+ + IKI++FG +R++ R + PEY APE+ +D ++
Sbjct: 31367 IGHFDIRPENIIYQTRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVS 31425
Query: 214 TATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSL 273
TATDMW++G + Y+LL+ +PF+ E NQ+ NI + EE F +S A DF+ L
Sbjct: 31426 TATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRL 31485
Query: 274 LVKNPEKRPTAEICLSHSWLQQ 295
LVK + R TA L H WL+Q
Sbjct: 31486 LVKERKSRMTASEALQHPWLKQ 31507
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 182 bits (463), Expect = 3e-46
Identities = 91/262 (34%), Positives = 157/262 (59%), Gaps = 6/262 (2%)
Query: 34 LTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRV 93
+ +++LGRG+F +V +C+ S+ + Y AKF+K + Q + EI++L +A+ +
Sbjct: 24947 MIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQ---VLVKKEISILNIARH-RNI 25002
Query: 94 INLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN 153
++LHE +E+ E+++I E+ +G +IF E+ +E +++ + Q+ E + +LH +N
Sbjct: 25003 LHLHESFESMEELVMIFEFISGLDIFERINTSAFEL-NEREIVSYVHQVCEALQFLHSHN 25061
Query: 154 IVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPIT 213
I H D++P+NI+ + IKI++FG +R++ R + PEY APE+ +D ++
Sbjct: 25062 IGHFDIRPENIIYQTRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVS 25120
Query: 214 TATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSL 273
TATDMW++G + Y+LL+ +PF+ E NQ+ NI + EE F +S A DF+ L
Sbjct: 25121 TATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRL 25180
Query: 274 LVKNPEKRPTAEICLSHSWLQQ 295
LVK + R TA L H WL+Q
Sbjct: 25181 LVKERKSRMTASEALQHPWLKQ 25202
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 182 bits (463), Expect = 3e-46
Identities = 91/262 (34%), Positives = 157/262 (59%), Gaps = 6/262 (2%)
Query: 34 LTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRV 93
+ +++LGRG+F +V +C+ S+ + Y AKF+K + Q + EI++L +A+ +
Sbjct: 24880 MIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQ---VLVKKEISILNIARH-RNI 24935
Query: 94 INLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN 153
++LHE +E+ E+++I E+ +G +IF E+ +E +++ + Q+ E + +LH +N
Sbjct: 24936 LHLHESFESMEELVMIFEFISGLDIFERINTSAFEL-NEREIVSYVHQVCEALQFLHSHN 24994
Query: 154 IVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPIT 213
I H D++P+NI+ + IKI++FG +R++ R + PEY APE+ +D ++
Sbjct: 24995 IGHFDIRPENIIYQTRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVS 25053
Query: 214 TATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSL 273
TATDMW++G + Y+LL+ +PF+ E NQ+ NI + EE F +S A DF+ L
Sbjct: 25054 TATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRL 25113
Query: 274 LVKNPEKRPTAEICLSHSWLQQ 295
LVK + R TA L H WL+Q
Sbjct: 25114 LVKERKSRMTASEALQHPWLKQ 25135
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 182 bits (463), Expect = 3e-46
Identities = 91/262 (34%), Positives = 157/262 (59%), Gaps = 6/262 (2%)
Query: 34 LTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRV 93
+ +++LGRG+F +V +C+ S+ + Y AKF+K + Q + EI++L +A+ +
Sbjct: 24755 MIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQ---VLVKKEISILNIARH-RNI 24810
Query: 94 INLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN 153
++LHE +E+ E+++I E+ +G +IF E+ +E +++ + Q+ E + +LH +N
Sbjct: 24811 LHLHESFESMEELVMIFEFISGLDIFERINTSAFEL-NEREIVSYVHQVCEALQFLHSHN 24869
Query: 154 IVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPIT 213
I H D++P+NI+ + IKI++FG +R++ R + PEY APE+ +D ++
Sbjct: 24870 IGHFDIRPENIIYQTRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVS 24928
Query: 214 TATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSL 273
TATDMW++G + Y+LL+ +PF+ E NQ+ NI + EE F +S A DF+ L
Sbjct: 24929 TATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRL 24988
Query: 274 LVKNPEKRPTAEICLSHSWLQQ 295
LVK + R TA L H WL+Q
Sbjct: 24989 LVKERKSRMTASEALQHPWLKQ 25010
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 181 bits (460), Expect = 7e-46
Identities = 94/269 (34%), Positives = 163/269 (60%), Gaps = 7/269 (2%)
Query: 26 ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLE 85
+NF++FY + ELGRG+F+VV++C K T + A KF+ K+ +D ++ HE+ +L+
Sbjct: 2790 DNFDSFYSEVA-ELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRD---QVTHELGILQ 2845
Query: 86 LAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEG 145
+ P ++ L + +E + IL+LE A G + C+ + +E + + ++LE
Sbjct: 2846 SLQH-PLLVGLLDTFETPTSYILVLEMADQGRLLD-CVVRWGSL-TEGKIRAHLGEVLEA 2902
Query: 146 VYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE 205
V YLH I HLDLKP+NIL+ IK+ DFG + ++ + +++G PE+ APE
Sbjct: 2903 VRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPE 2962
Query: 206 ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQL 265
I+ +P++ +D W++G++ Y+LL+ SPF+ + +ET LNI +++ + ++ F VSQ
Sbjct: 2963 IILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQK 3022
Query: 266 ATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294
A +F+ LL ++P KRP+A + L WLQ
Sbjct: 3023 AKEFVCFLLQEDPAKRPSAALALQEQWLQ 3051
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 169 bits (427), Expect = 5e-42
Identities = 99/273 (36%), Positives = 142/273 (52%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ TGQEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I+QILE V + H N IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCHLNGIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
DMW G+I Y+LL PF ED Y I D+ + +V+ A D I +L
Sbjct: 195 VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITASEALKHPWICQRSTVASMMHRQET 287
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 169 bits (427), Expect = 5e-42
Identities = 99/273 (36%), Positives = 142/273 (52%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ TGQEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I+QILE V + H N IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCHLNGIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
DMW G+I Y+LL PF ED Y I D+ + +V+ A D I +L
Sbjct: 195 VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITASEALKHPWICQRSTVASMMHRQET 287
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 169 bits (427), Expect = 5e-42
Identities = 99/273 (36%), Positives = 142/273 (52%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ TGQEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I+QILE V + H N IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCHLNGIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
DMW G+I Y+LL PF ED Y I D+ + +V+ A D I +L
Sbjct: 195 VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITASEALKHPWICQRSTVASMMHRQET 287
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 169 bits (427), Expect = 5e-42
Identities = 99/273 (36%), Positives = 142/273 (52%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ TGQEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I+QILE V + H N IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCHLNGIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
DMW G+I Y+LL PF ED Y I D+ + +V+ A D I +L
Sbjct: 195 VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITASEALKHPWICQRSTVASMMHRQET 287
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 169 bits (427), Expect = 5e-42
Identities = 99/273 (36%), Positives = 142/273 (52%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ TGQEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I+QILE V + H N IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCHLNGIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
DMW G+I Y+LL PF ED Y I D+ + +V+ A D I +L
Sbjct: 195 VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITASEALKHPWICQRSTVASMMHRQET 287
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 169 bits (427), Expect = 5e-42
Identities = 99/273 (36%), Positives = 142/273 (52%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ TGQEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I+QILE V + H N IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCHLNGIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
DMW G+I Y+LL PF ED Y I D+ + +V+ A D I +L
Sbjct: 195 VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITASEALKHPWICQRSTVASMMHRQET 287
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 168 bits (426), Expect = 6e-42
Identities = 109/301 (36%), Positives = 162/301 (53%), Gaps = 24/301 (7%)
Query: 39 LGRGKFAVVRQCISKSTGQEYAAKFLK-KRRRGQD-CRAEILHEIAVLELAKSCPRVINL 96
+GRG F+ V + ++T Q YA K ++ K R G++ C +E+ VL + +I L
Sbjct: 104 IGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESEL----RVLRRVRHA-NIIQL 158
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
EV+E + +++E A GGE+F + + + +E D R+++ +L+GV YLH I H
Sbjct: 159 VEVFETQERVYMVMELATGGELFDRIIAKGS--FTERDATRVLQMVLDGVRYLHALGITH 216
Query: 157 LDLKPQNILLSSIYPLGDIKIV--DFGMS--RKIGHACELREIMGTPEYLAPEILNYDPI 212
DLKP+N+L +P D KI+ DFG++ RK G C ++ GTPEY+APE+L P
Sbjct: 217 RDLKPENLLY--YHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPY 274
Query: 213 TTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQS 272
T + DMW +G+IAY+LL+ T PF ++ Y I + YS E + SVS LA DFI
Sbjct: 275 TNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDR 334
Query: 273 LLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNG 332
LL +P R TA L H W+ SSS + S+ + K + S C
Sbjct: 335 LLTVDPGARMTALQALRHPWVVSM---------AASSSMKNLHRSISQNLLKRASSRCQS 385
Query: 333 T 333
T
Sbjct: 386 T 386
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 168 bits (426), Expect = 6e-42
Identities = 95/274 (34%), Positives = 165/274 (60%), Gaps = 24/274 (8%)
Query: 29 NNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVL-ELA 87
++FY + +E+GRG F+ +R+ + +S+G E+AAKF+ + + +A E +L L
Sbjct: 1598 SDFYDI-HQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKP---KASARREARLLARLQ 1653
Query: 88 KSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVS------ENDVIRLIKQ 141
C V+ HE +E ++++ E LC EL E ++ E+++ ++Q
Sbjct: 1654 HDC--VLYFHEAFERRRGLVIVTE---------LCTEELLERIARKPTVCESEIRAYMRQ 1702
Query: 142 ILEGVYYLHQNNIVHLDLKPQNILL-SSIYPLGDIKIVDFGMSRKIGHACELREIMGTPE 200
+LEG++YLHQ++++HLD+KP+N+L+ ++I DFG ++++ GTPE
Sbjct: 1703 VLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPE 1762
Query: 201 YLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFS 260
++APEI+N P++ TD+W +G++A++ LT SPFVGE+++ T +NI NV + E TF
Sbjct: 1763 FVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFL 1822
Query: 261 SVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294
S+S+ A F+ +LV++ RPTAE L H W +
Sbjct: 1823 SLSREARGFLIKVLVQD-RLRPTAEETLEHPWFK 1855
Score = 153 bits (386), Expect = 3e-37
Identities = 95/266 (35%), Positives = 147/266 (55%), Gaps = 24/266 (9%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+E RG+F VVR C +TG+ + AK + G + +L E VL R+++L
Sbjct: 2970 EEKARGRFGVVRACRENATGRTFVAKIVPYAAEG---KRRVLQEYEVLRTLHH-ERIMSL 3025
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
HE Y ++LI E E+ LC SE+DV + Q+L+G+ YLH ++++H
Sbjct: 3026 HEAYITPRYLVLIAESCGNREL--LCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLH 3083
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMS--------RKIGHACELREIMGTPEYLAPEILN 208
LD+KP N+LL+ P +KIVDFG + R +GH GT E++APE++
Sbjct: 3084 LDIKPDNLLLA---PDNALKIVDFGSAQPYNPQALRPLGHRT------GTLEFMAPEMVK 3134
Query: 209 YDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATD 268
+PI +ATD+W G++ Y++L+ SPF D QET I D + + + + SQ AT
Sbjct: 3135 GEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFD-AFQLYPNTSQSATL 3193
Query: 269 FIQSLLVKNPEKRPTAEICLSHSWLQ 294
F++ +L +P RP+ + CL+H WLQ
Sbjct: 3194 FLRKVLSVHPWSRPSLQDCLAHPWLQ 3219
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 168 bits (425), Expect = 8e-42
Identities = 96/273 (35%), Positives = 147/273 (53%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ K++ QEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I QILE V ++HQ++IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILESVNHIHQHDIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
D+W G+I Y+LL PF ED + Y I D+ + +V+ A + I +L
Sbjct: 195 VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA+ L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITADQALKHPWVCQRSTVASMMHRQET 287
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 168 bits (425), Expect = 8e-42
Identities = 96/273 (35%), Positives = 147/273 (53%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ K++ QEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I QILE V ++HQ++IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILESVNHIHQHDIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
D+W G+I Y+LL PF ED + Y I D+ + +V+ A + I +L
Sbjct: 195 VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA+ L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITADQALKHPWVCQRSTVASMMHRQET 287
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 168 bits (425), Expect = 8e-42
Identities = 96/273 (35%), Positives = 147/273 (53%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ K++ QEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I QILE V ++HQ++IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILESVNHIHQHDIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
D+W G+I Y+LL PF ED + Y I D+ + +V+ A + I +L
Sbjct: 195 VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA+ L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITADQALKHPWVCQRSTVASMMHRQET 287
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 168 bits (425), Expect = 8e-42
Identities = 96/273 (35%), Positives = 147/273 (53%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ K++ QEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I QILE V ++HQ++IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILESVNHIHQHDIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
D+W G+I Y+LL PF ED + Y I D+ + +V+ A + I +L
Sbjct: 195 VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA+ L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITADQALKHPWVCQRSTVASMMHRQET 287
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 168 bits (425), Expect = 8e-42
Identities = 96/273 (35%), Positives = 147/273 (53%), Gaps = 5/273 (1%)
Query: 37 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96
+ELG+G F+VVR+C+ K++ QEYAAK + ++ ++ E + L K P ++ L
Sbjct: 18 EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PNIVRL 76
Query: 97 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 156
H+ L+ + GGE+F + E SE D I QILE V ++HQ++IVH
Sbjct: 77 HDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILESVNHIHQHDIVH 134
Query: 157 LDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITTA 215
DLKP+N+LL+S +K+ DFG++ ++ G GTP YL+PE+L DP
Sbjct: 135 RDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKP 194
Query: 216 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLV 275
D+W G+I Y+LL PF ED + Y I D+ + +V+ A + I +L
Sbjct: 195 VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254
Query: 276 KNPEKRPTAEICLSHSWL-QQWDFENLFHPEET 307
NP KR TA+ L H W+ Q+ ++ H +ET
Sbjct: 255 INPAKRITADQALKHPWVCQRSTVASMMHRQET 287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,890,977
Number of Sequences: 37866
Number of extensions: 585393
Number of successful extensions: 4174
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 646
Number of HSP's successfully gapped in prelim test: 146
Number of HSP's that attempted gapping in prelim test: 1837
Number of HSP's gapped (non-prelim): 934
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.