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Search of human proteins with 47078261
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47078261 double C2-like domains, alpha [Homo sapiens]
(400 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47078261 double C2-like domains, alpha [Homo sapiens] 818 0.0
gi|6005997 double C2-like domains, beta [Homo sapiens] 498 e-141
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 421 e-118
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 421 e-118
gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo sap... 326 2e-89
gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens] 317 9e-87
gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens] 317 9e-87
gi|38570146 synaptotagmin VII [Homo sapiens] 178 9e-45
gi|211059429 synaptotagmin II [Homo sapiens] 170 2e-42
gi|31543670 synaptotagmin II [Homo sapiens] 170 2e-42
gi|209447073 synaptotagmin I [Homo sapiens] 168 9e-42
gi|5032139 synaptotagmin I [Homo sapiens] 168 9e-42
gi|209447070 synaptotagmin I [Homo sapiens] 168 9e-42
gi|92859638 synaptotagmin V [Homo sapiens] 164 1e-40
gi|45504376 synaptotagmin VI [Homo sapiens] 155 6e-38
gi|24308219 synaptotagmin IV [Homo sapiens] 150 2e-36
gi|39752671 synaptotagmin X [Homo sapiens] 149 3e-36
gi|238550198 synaptotagmin III [Homo sapiens] 147 1e-35
gi|238550196 synaptotagmin III [Homo sapiens] 147 1e-35
gi|14150054 synaptotagmin III [Homo sapiens] 147 1e-35
gi|216548478 synaptotagmin XI [Homo sapiens] 140 3e-33
gi|28376627 synaptotagmin IX [Homo sapiens] 140 3e-33
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 124 1e-28
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 124 1e-28
gi|40068038 B/K protein [Homo sapiens] 110 2e-24
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 108 7e-24
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 108 7e-24
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 108 7e-24
gi|123173752 synaptotagmin XIV-like [Homo sapiens] 108 1e-23
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens] 97 3e-20
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 818 bits (2112), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLA 60
MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLA
Sbjct: 1 MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLA 60
Query: 61 LAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMD 120
LAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMD
Sbjct: 61 LAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMD 120
Query: 121 FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVC 180
FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVC
Sbjct: 121 FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVC 180
Query: 181 DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE 240
DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE
Sbjct: 181 DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE 240
Query: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300
QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD
Sbjct: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300
Query: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360
KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG
Sbjct: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360
Query: 361 ARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA 400
ARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA
Sbjct: 361 ARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA 400
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 498 bits (1281), Expect = e-141
Identities = 259/426 (60%), Positives = 292/426 (68%), Gaps = 58/426 (13%)
Query: 4 RRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPG---PEGGGGGGGEAPAHLVPLA 60
RRG++ TI+IQEHMAI+VCPGPIRPI+QISDYFPR P P+ G A P
Sbjct: 5 RRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAV 64
Query: 61 LA---------------------------------PPAALLGATTPEDGAEVDSYDSDDA 87
P A A PED + D Y+SDD
Sbjct: 65 AGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDC 124
Query: 88 TALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKT 147
TALGTL+F LLYD+ + LHC+I +AKGLKPMD NGLADPYVKLHLLPGA KANKL+TKT
Sbjct: 125 TALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKT 184
Query: 148 QRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKK 207
RNTLNP WNE LTY GITD+D+ K LRI+VCDEDK HNEFIGE RVPL++LKP+ K
Sbjct: 185 LRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTK 244
Query: 208 HFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRG 267
FNICLE+Q+P+ S LEERGRIL+SL YSS+++G
Sbjct: 245 TFNICLEKQLPVDKTEDKS----------------------LEERGRILISLKYSSQKQG 282
Query: 268 LLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIE 327
LLVGI+RCAHLAAMD NGYSDPYVKTYLRPDVDKKSKHKT VKKKTLNPEFNEEF YEI+
Sbjct: 283 LLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIK 342
Query: 328 LSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLT 387
LA K+LEVTVWDYDIGKSNDFIGGV LG A+GE KHW DCL+ D +ERWHTLT
Sbjct: 343 HGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLT 402
Query: 388 SELPPA 393
SELP A
Sbjct: 403 SELPGA 408
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 421 bits (1081), Expect = e-118
Identities = 203/327 (62%), Positives = 256/327 (78%), Gaps = 4/327 (1%)
Query: 63 PPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFN 122
P AA E+ E +SYDSD+AT LG LEF LLYD+ + +L C+I++AKGLKPMD N
Sbjct: 366 PAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSN 425
Query: 123 GLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDE 182
GLADPYVKLHLLPGA K+NKL+TKT RNT NP+WNE L Y GITD+D+ K LRI+VCDE
Sbjct: 426 GLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDE 485
Query: 183 DKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQA 242
DK HNEFIGE R L++LKP+Q+K+FNICLER +P+ + +A RG++ Y E EQ
Sbjct: 486 DKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSA-RGMALY--EEEQV 542
Query: 243 EQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKK 302
E+ G +EERG+IL+SL YS+++ GL+VGI+RC HLAAMD NGYSDP+VK +L+PD+ KK
Sbjct: 543 ER-VGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKK 601
Query: 303 SKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGAR 362
+KHKT +KKKTLNPEFNEEFFY+I+ S LA K+L+++VWDYDIGKSND+IGG LG A+
Sbjct: 602 AKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAK 661
Query: 363 GEARKHWSDCLQQPDAALERWHTLTSE 389
GE KHW +CL+ D +ERWH L +E
Sbjct: 662 GERLKHWYECLKNKDKKIERWHQLQNE 688
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 421 bits (1081), Expect = e-118
Identities = 203/327 (62%), Positives = 256/327 (78%), Gaps = 4/327 (1%)
Query: 63 PPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFN 122
P AA E+ E +SYDSD+AT LG LEF LLYD+ + +L C+I++AKGLKPMD N
Sbjct: 362 PAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSN 421
Query: 123 GLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDE 182
GLADPYVKLHLLPGA K+NKL+TKT RNT NP+WNE L Y GITD+D+ K LRI+VCDE
Sbjct: 422 GLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDE 481
Query: 183 DKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQA 242
DK HNEFIGE R L++LKP+Q+K+FNICLER +P+ + +A RG++ Y E EQ
Sbjct: 482 DKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSA-RGMALY--EEEQV 538
Query: 243 EQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKK 302
E+ G +EERG+IL+SL YS+++ GL+VGI+RC HLAAMD NGYSDP+VK +L+PD+ KK
Sbjct: 539 ER-VGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKK 597
Query: 303 SKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGAR 362
+KHKT +KKKTLNPEFNEEFFY+I+ S LA K+L+++VWDYDIGKSND+IGG LG A+
Sbjct: 598 AKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAK 657
Query: 363 GEARKHWSDCLQQPDAALERWHTLTSE 389
GE KHW +CL+ D +ERWH L +E
Sbjct: 658 GERLKHWYECLKNKDKKIERWHQLQNE 684
>gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo
sapiens]
Length = 431
Score = 326 bits (836), Expect = 2e-89
Identities = 193/396 (48%), Positives = 243/396 (61%), Gaps = 45/396 (11%)
Query: 6 GDRMTINIQEHMAINVCPGPIRPIRQISDYFPRG-PGPEGGGGGGGEAPAHLVPLALAPP 64
G +++QEHMAI+V PGPIRPIR IS YFP P E PA L P L P
Sbjct: 63 GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAE---------PA-LHPPNLRPA 112
Query: 65 AALLGATTPEDGAEVDSY-DSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNG 123
AA + P+ + + DSDD+TALGTLEF LL++ + LHC+ RAKGLKP+ +G
Sbjct: 113 AASAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SG 171
Query: 124 LADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRI------ 177
AD YVK +LLPGA KA++L+T T R T PVW E LTY G T D K LR
Sbjct: 172 SADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQ 231
Query: 178 AVCDEDKLSHNEF----IGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGIS 233
AVC + ++ +GE+RVPLR+L P++ + F+ICLE+
Sbjct: 232 AVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEK------------------ 273
Query: 234 CYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKT 293
+ LE+ E + EE G +LLSL YSS++ GLLVG+LRCAHLA MD NGYSDP+V+
Sbjct: 274 ---RRLEEVET-EVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRL 329
Query: 294 YLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIG 353
+L P+ KKSK KT V +KTLNPEFNEEFFY LA KTL V+VWDYD+G ++DFIG
Sbjct: 330 FLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 389
Query: 354 GVSLGPGARGEARKHWSDCLQQPDAALERWHTLTSE 389
GV LG A GE +HW +CL D L+ WH L S+
Sbjct: 390 GVQLGSHASGERLRHWLECLGHSDHRLKLWHPLDSK 425
>gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 317 bits (813), Expect = 9e-87
Identities = 199/449 (44%), Positives = 251/449 (55%), Gaps = 77/449 (17%)
Query: 6 GDRMTINIQEHMAINVCPGPIRPIRQISDYFPRG-PGPEGGGGGGGEAPAHLVPLALAPP 64
G +++QEHMAI+V PGPIRPIR IS YFP P E PA L P L P
Sbjct: 9 GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAE---------PA-LHPPNLRPA 58
Query: 65 AALLGATTPEDGAEVDSY-DSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNG 123
AA + P+ + + DSDD+TALGTLEF LL++ + LHC+ RAKGLKP+ +G
Sbjct: 59 AASAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SG 117
Query: 124 LADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRI------ 177
AD YVK +LLPGA KA++L+T T R T PVW E LTY G T D K LR
Sbjct: 118 SADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQ 177
Query: 178 AVCDEDKLSHNEF----IGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSA------ 227
AVC + ++ +GE+RVPLR+L P++ + F+ICLE++ P S+
Sbjct: 178 AVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSL 237
Query: 228 ------------ALRGISCYL-----------------------------------KELE 240
A SC L + +E
Sbjct: 238 YEVVPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSME 297
Query: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300
+ E + EE G +LLSL YSS++ GLLVG+LRCAHLA MD NGYSDP+V+ +L P+
Sbjct: 298 EVET-EVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
Query: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360
KKSK KT V +KTLNPEFNEEFFY LA KTL V+VWDYD+G ++DFIGGV LG
Sbjct: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSH 416
Query: 361 ARGEARKHWSDCLQQPDAALERWHTLTSE 389
A GE +HW +CL D LE WH L S+
Sbjct: 417 ASGERLRHWLECLGHSDHRLELWHPLDSK 445
>gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 317 bits (813), Expect = 9e-87
Identities = 199/449 (44%), Positives = 251/449 (55%), Gaps = 77/449 (17%)
Query: 6 GDRMTINIQEHMAINVCPGPIRPIRQISDYFPRG-PGPEGGGGGGGEAPAHLVPLALAPP 64
G +++QEHMAI+V PGPIRPIR IS YFP P E PA L P L P
Sbjct: 9 GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAE---------PA-LHPPNLRPA 58
Query: 65 AALLGATTPEDGAEVDSY-DSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNG 123
AA + P+ + + DSDD+TALGTLEF LL++ + LHC+ RAKGLKP+ +G
Sbjct: 59 AASAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SG 117
Query: 124 LADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRI------ 177
AD YVK +LLPGA KA++L+T T R T PVW E LTY G T D K LR
Sbjct: 118 SADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQ 177
Query: 178 AVCDEDKLSHNEF----IGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSA------ 227
AVC + ++ +GE+RVPLR+L P++ + F+ICLE++ P S+
Sbjct: 178 AVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSL 237
Query: 228 ------------ALRGISCYL-----------------------------------KELE 240
A SC L + +E
Sbjct: 238 YEVVPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSME 297
Query: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300
+ E + EE G +LLSL YSS++ GLLVG+LRCAHLA MD NGYSDP+V+ +L P+
Sbjct: 298 EVET-EVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
Query: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360
KKSK KT V +KTLNPEFNEEFFY LA KTL V+VWDYD+G ++DFIGGV LG
Sbjct: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSH 416
Query: 361 ARGEARKHWSDCLQQPDAALERWHTLTSE 389
A GE +HW +CL D LE WH L S+
Sbjct: 417 ASGERLRHWLECLGHSDHRLELWHPLDSK 445
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 178 bits (451), Expect = 9e-45
Identities = 102/309 (33%), Positives = 158/309 (51%), Gaps = 31/309 (10%)
Query: 78 EVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGA 137
E ++++ LG ++F + Y+ TL I++A+ L DF+G +DP+VK++LLP
Sbjct: 124 EDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPD- 182
Query: 138 CKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVP 197
K +KL+TK +R LNP WNE + G + + ++L + V D D+ S N+ IGE+ +P
Sbjct: 183 -KKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIP 241
Query: 198 LRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILL 257
L ++ +Q + F K+L+ G G RG +LL
Sbjct: 242 LNKVDLTQMQTF--------------------------WKDLKPCSDGSG---SRGELLL 272
Query: 258 SLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPE 317
SL Y+ ++V I++ +L AMD+ G SDPYVK +L + K KT K+ LNP
Sbjct: 273 SLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPI 332
Query: 318 FNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPD 377
FNE F ++I L T+ +TV D D ND IG + L + KHW D + +P
Sbjct: 333 FNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPR 392
Query: 378 AALERWHTL 386
+ +WH L
Sbjct: 393 QPVAQWHQL 401
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 170 bits (431), Expect = 2e-42
Identities = 113/312 (36%), Positives = 154/312 (49%), Gaps = 31/312 (9%)
Query: 78 EVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGA 137
E + + + LG L+F L YD + L +L+A L +D G +DPYVK+ LLP
Sbjct: 128 EGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPD- 186
Query: 138 CKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVP 197
K K +TK R TLNP +NE T+ + ++ K L +A+ D D+ S ++ IGE++VP
Sbjct: 187 -KKKKYETKVHRKTLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVP 244
Query: 198 LRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILL 257
+ V L P L+G E E+ E+ G I
Sbjct: 245 M----------------NTVDLGQPIEEWRDLQG-----GEKEEP-------EKLGDICT 276
Query: 258 SLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPE 317
SL Y L V IL +L MDV G SDPYVK +L + + K KT VKKKTLNP
Sbjct: 277 SLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPY 336
Query: 318 FNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPD 377
FNE F +EI + + VTV DYD N+ IG + +G A G +HWSD L P
Sbjct: 337 FNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPR 396
Query: 378 AALERWHTLTSE 389
+ +WH+L E
Sbjct: 397 RPIAQWHSLKPE 408
Score = 77.0 bits (188), Expect = 3e-14
Identities = 45/123 (36%), Positives = 66/123 (53%), Gaps = 1/123 (0%)
Query: 74 EDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHL 133
E+ ++ + ++ LG + L Y + L IL AK LK MD GL+DPYVK+HL
Sbjct: 255 EEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHL 314
Query: 134 LPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGE 193
+ + K KT ++ TLNP +NE ++ I + I + + V D DKL NE IG+
Sbjct: 315 MQNGKRLKKKKTTVKKKTLNPYFNESFSFE-IPFEQIQKVQVVVTVLDYDKLGKNEAIGK 373
Query: 194 IRV 196
I V
Sbjct: 374 IFV 376
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 170 bits (431), Expect = 2e-42
Identities = 113/312 (36%), Positives = 154/312 (49%), Gaps = 31/312 (9%)
Query: 78 EVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGA 137
E + + + LG L+F L YD + L +L+A L +D G +DPYVK+ LLP
Sbjct: 128 EGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPD- 186
Query: 138 CKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVP 197
K K +TK R TLNP +NE T+ + ++ K L +A+ D D+ S ++ IGE++VP
Sbjct: 187 -KKKKYETKVHRKTLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVP 244
Query: 198 LRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILL 257
+ V L P L+G E E+ E+ G I
Sbjct: 245 M----------------NTVDLGQPIEEWRDLQG-----GEKEEP-------EKLGDICT 276
Query: 258 SLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPE 317
SL Y L V IL +L MDV G SDPYVK +L + + K KT VKKKTLNP
Sbjct: 277 SLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPY 336
Query: 318 FNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPD 377
FNE F +EI + + VTV DYD N+ IG + +G A G +HWSD L P
Sbjct: 337 FNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPR 396
Query: 378 AALERWHTLTSE 389
+ +WH+L E
Sbjct: 397 RPIAQWHSLKPE 408
Score = 77.0 bits (188), Expect = 3e-14
Identities = 45/123 (36%), Positives = 66/123 (53%), Gaps = 1/123 (0%)
Query: 74 EDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHL 133
E+ ++ + ++ LG + L Y + L IL AK LK MD GL+DPYVK+HL
Sbjct: 255 EEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHL 314
Query: 134 LPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGE 193
+ + K KT ++ TLNP +NE ++ I + I + + V D DKL NE IG+
Sbjct: 315 MQNGKRLKKKKTTVKKKTLNPYFNESFSFE-IPFEQIQKVQVVVTVLDYDKLGKNEAIGK 373
Query: 194 IRV 196
I V
Sbjct: 374 IFV 376
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 168 bits (425), Expect = 9e-42
Identities = 112/315 (35%), Positives = 157/315 (49%), Gaps = 33/315 (10%)
Query: 75 DGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLL 134
DG E + ++ LG L++ L YD + L I++A L +D G +DPYVK+ LL
Sbjct: 130 DGEEKEEPKEEEK--LGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLL 187
Query: 135 PGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEI 194
P K K +TK R TLNPV+NE T+ + ++ K L +AV D D+ S ++ IGE
Sbjct: 188 PD--KKKKFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFSKHDIIGEF 244
Query: 195 RVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGR 254
+VP+ + F E ++L+ AE+ + E+ G
Sbjct: 245 KVPMNTVD------FGHVTEEW--------------------RDLQSAEKEEQ--EKLGD 276
Query: 255 ILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTL 314
I SL Y L V IL +L MDV G SDPYVK +L + + K KT +KK TL
Sbjct: 277 ICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTL 336
Query: 315 NPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQ 374
NP +NE F +E+ + + VTV DYD ND IG V +G + G +HWSD L
Sbjct: 337 NPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLA 396
Query: 375 QPDAALERWHTLTSE 389
P + +WHTL E
Sbjct: 397 NPRRPIAQWHTLQVE 411
Score = 96.7 bits (239), Expect = 3e-20
Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 6/153 (3%)
Query: 250 EERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCV 309
E+ G++ SL Y + LLVGI++ A L A+D+ G SDPYVK +L P DKK K +T V
Sbjct: 141 EKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DKKKKFETKV 198
Query: 310 KKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIG--GVSLGPGARGEARK 367
+KTLNP FNE+F +++ S L KTL + V+D+D +D IG V + G +
Sbjct: 199 HRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTE 258
Query: 368 HWSDCLQQPDAALERWHTLTSEL--PPAAGALS 398
W D E+ + L P AG L+
Sbjct: 259 EWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLT 291
Score = 81.3 bits (199), Expect = 1e-15
Identities = 44/123 (35%), Positives = 69/123 (56%), Gaps = 1/123 (0%)
Query: 74 EDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHL 133
E+ ++ S + ++ LG + F L Y + L IL AK LK MD GL+DPYVK+HL
Sbjct: 258 EEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHL 317
Query: 134 LPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGE 193
+ + K KT ++NTLNP +NE ++ + + I + + V D DK+ N+ IG+
Sbjct: 318 MQNGKRLKKKKTTIKKNTLNPYYNESFSFE-VPFEQIQKVQVVVTVLDYDKIGKNDAIGK 376
Query: 194 IRV 196
+ V
Sbjct: 377 VFV 379
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 168 bits (425), Expect = 9e-42
Identities = 112/315 (35%), Positives = 157/315 (49%), Gaps = 33/315 (10%)
Query: 75 DGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLL 134
DG E + ++ LG L++ L YD + L I++A L +D G +DPYVK+ LL
Sbjct: 130 DGEEKEEPKEEEK--LGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLL 187
Query: 135 PGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEI 194
P K K +TK R TLNPV+NE T+ + ++ K L +AV D D+ S ++ IGE
Sbjct: 188 PD--KKKKFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFSKHDIIGEF 244
Query: 195 RVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGR 254
+VP+ + F E ++L+ AE+ + E+ G
Sbjct: 245 KVPMNTVD------FGHVTEEW--------------------RDLQSAEKEEQ--EKLGD 276
Query: 255 ILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTL 314
I SL Y L V IL +L MDV G SDPYVK +L + + K KT +KK TL
Sbjct: 277 ICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTL 336
Query: 315 NPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQ 374
NP +NE F +E+ + + VTV DYD ND IG V +G + G +HWSD L
Sbjct: 337 NPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLA 396
Query: 375 QPDAALERWHTLTSE 389
P + +WHTL E
Sbjct: 397 NPRRPIAQWHTLQVE 411
Score = 96.7 bits (239), Expect = 3e-20
Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 6/153 (3%)
Query: 250 EERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCV 309
E+ G++ SL Y + LLVGI++ A L A+D+ G SDPYVK +L P DKK K +T V
Sbjct: 141 EKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DKKKKFETKV 198
Query: 310 KKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIG--GVSLGPGARGEARK 367
+KTLNP FNE+F +++ S L KTL + V+D+D +D IG V + G +
Sbjct: 199 HRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTE 258
Query: 368 HWSDCLQQPDAALERWHTLTSEL--PPAAGALS 398
W D E+ + L P AG L+
Sbjct: 259 EWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLT 291
Score = 81.3 bits (199), Expect = 1e-15
Identities = 44/123 (35%), Positives = 69/123 (56%), Gaps = 1/123 (0%)
Query: 74 EDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHL 133
E+ ++ S + ++ LG + F L Y + L IL AK LK MD GL+DPYVK+HL
Sbjct: 258 EEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHL 317
Query: 134 LPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGE 193
+ + K KT ++NTLNP +NE ++ + + I + + V D DK+ N+ IG+
Sbjct: 318 MQNGKRLKKKKTTIKKNTLNPYYNESFSFE-VPFEQIQKVQVVVTVLDYDKIGKNDAIGK 376
Query: 194 IRV 196
+ V
Sbjct: 377 VFV 379
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 168 bits (425), Expect = 9e-42
Identities = 112/315 (35%), Positives = 157/315 (49%), Gaps = 33/315 (10%)
Query: 75 DGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLL 134
DG E + ++ LG L++ L YD + L I++A L +D G +DPYVK+ LL
Sbjct: 130 DGEEKEEPKEEEK--LGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLL 187
Query: 135 PGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEI 194
P K K +TK R TLNPV+NE T+ + ++ K L +AV D D+ S ++ IGE
Sbjct: 188 PD--KKKKFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFSKHDIIGEF 244
Query: 195 RVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGR 254
+VP+ + F E ++L+ AE+ + E+ G
Sbjct: 245 KVPMNTVD------FGHVTEEW--------------------RDLQSAEKEEQ--EKLGD 276
Query: 255 ILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTL 314
I SL Y L V IL +L MDV G SDPYVK +L + + K KT +KK TL
Sbjct: 277 ICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTL 336
Query: 315 NPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQ 374
NP +NE F +E+ + + VTV DYD ND IG V +G + G +HWSD L
Sbjct: 337 NPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLA 396
Query: 375 QPDAALERWHTLTSE 389
P + +WHTL E
Sbjct: 397 NPRRPIAQWHTLQVE 411
Score = 96.7 bits (239), Expect = 3e-20
Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 6/153 (3%)
Query: 250 EERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCV 309
E+ G++ SL Y + LLVGI++ A L A+D+ G SDPYVK +L P DKK K +T V
Sbjct: 141 EKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DKKKKFETKV 198
Query: 310 KKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIG--GVSLGPGARGEARK 367
+KTLNP FNE+F +++ S L KTL + V+D+D +D IG V + G +
Sbjct: 199 HRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTE 258
Query: 368 HWSDCLQQPDAALERWHTLTSEL--PPAAGALS 398
W D E+ + L P AG L+
Sbjct: 259 EWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLT 291
Score = 81.3 bits (199), Expect = 1e-15
Identities = 44/123 (35%), Positives = 69/123 (56%), Gaps = 1/123 (0%)
Query: 74 EDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHL 133
E+ ++ S + ++ LG + F L Y + L IL AK LK MD GL+DPYVK+HL
Sbjct: 258 EEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHL 317
Query: 134 LPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGE 193
+ + K KT ++NTLNP +NE ++ + + I + + V D DK+ N+ IG+
Sbjct: 318 MQNGKRLKKKKTTIKKNTLNPYYNESFSFE-VPFEQIQKVQVVVTVLDYDKIGKNDAIGK 376
Query: 194 IRV 196
+ V
Sbjct: 377 VFV 379
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 164 bits (416), Expect = 1e-40
Identities = 108/301 (35%), Positives = 152/301 (50%), Gaps = 31/301 (10%)
Query: 86 DATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKT 145
D LG L++ L YD S L IL+A GL +D G +DPYV+++LLP K + +T
Sbjct: 105 DKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPD--KRRRYET 162
Query: 146 KTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQ 205
K R TLNP + E + + ++ +VL +AV D D+ S N+ IGE+RVP+
Sbjct: 163 KVHRQTLNPHFGETFAFK-VPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMS------ 215
Query: 206 KKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRR 265
V L P +EL+ A + + E+ G I SL Y
Sbjct: 216 ----------SVDLGRPVQA----------WRELQAAPREEQ--EKLGDICFSLRYVPTA 253
Query: 266 RGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYE 325
L V +L +L MDV G SDPYVK +L K K KT +KK TLNP +NE F +E
Sbjct: 254 GKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFE 313
Query: 326 IELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHT 385
+ + +E+TV DYD N+ IG V++G A G +HW+D L P + +WH+
Sbjct: 314 VPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHS 373
Query: 386 L 386
L
Sbjct: 374 L 374
Score = 85.5 bits (210), Expect = 8e-17
Identities = 47/119 (39%), Positives = 66/119 (55%), Gaps = 1/119 (0%)
Query: 78 EVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGA 137
E+ + ++ LG + F L Y + L +L AK LK MD GL+DPYVK+HLL G
Sbjct: 228 ELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGG 287
Query: 138 CKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRV 196
K K KT ++NTLNP +NE ++ + D + + + V D DKL NE IG + V
Sbjct: 288 KKVRKKKTTIKKNTLNPYYNEAFSFE-VPCDQVQKVQVELTVLDYDKLGKNEAIGRVAV 345
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 155 bits (392), Expect = 6e-38
Identities = 107/332 (32%), Positives = 162/332 (48%), Gaps = 38/332 (11%)
Query: 63 PPAA----LLGATTPE--DGAEVDSYD--SDDATALGTLEFDLLYDRASCTLHCSILRAK 114
PPAA +G PE VD D S+ + G + F L YD + TL IL+A
Sbjct: 110 PPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAF 169
Query: 115 GLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKV 174
L DF G +DPYVK++LLP + KL+T+ R TLNP ++E+ + + +++ +
Sbjct: 170 DLPAKDFCGSSDPYVKIYLLPD--RKCKLQTRVHRKTLNPTFDENFHFP-VPYEELADRK 226
Query: 175 LRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISC 234
L ++V D D+ S ++ IGE V L L + + + + A+ S+
Sbjct: 227 LHLSVFDFDRFSRHDMIGE--VILDNLFEASDLSRETSIWKDIQYATSESV--------- 275
Query: 235 YLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTY 294
+ G I+ SL Y L + +++C +L AMD+ GYSDPYVK
Sbjct: 276 ----------------DLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVS 319
Query: 295 LRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGG 354
L D + K KT +KK TLNP +NE ++I + +L ++V DYD N+ IG
Sbjct: 320 LLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGV 379
Query: 355 VSLGPGARGEARKHWSDCLQQPDAALERWHTL 386
+G A G R HW++ L P + WH+L
Sbjct: 380 CRVGITAEGLGRDHWNEMLAYPRKPIAHWHSL 411
>gi|24308219 synaptotagmin IV [Homo sapiens]
Length = 425
Score = 150 bits (379), Expect = 2e-36
Identities = 103/319 (32%), Positives = 154/319 (48%), Gaps = 31/319 (9%)
Query: 70 ATTPEDGAEVDSYDSDDATA-LGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGL-ADP 127
+ +PE S S++ LGTL F L Y+ +I A+GL MD + +DP
Sbjct: 133 SVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDP 192
Query: 128 YVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSH 187
Y+K+ +LP K +K+KT+ R TL+P ++E T+ GI I L + D+ S
Sbjct: 193 YIKMTILPE--KKHKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSR 250
Query: 188 NEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQG 247
++ IGE+ +PL ++ S+ K + + R++ +K + G
Sbjct: 251 DDIIGEVLIPLSGIELSEGK---MLMNREI------------------IKRNVRKSSG-- 287
Query: 248 LLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKT 307
RG +L+SL Y S L V +L+ HL DV+G SDPYVK L + SK KT
Sbjct: 288 ----RGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKT 343
Query: 308 CVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARK 367
VKK T N FNE F ++I L ++E V D + G N+ IG + LG A G +
Sbjct: 344 HVKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGGE 403
Query: 368 HWSDCLQQPDAALERWHTL 386
HW + P + +WH L
Sbjct: 404 HWKEICDYPRRQIAKWHVL 422
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 149 bits (377), Expect = 3e-36
Identities = 98/326 (30%), Positives = 152/326 (46%), Gaps = 31/326 (9%)
Query: 74 EDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHL 133
+ + + ++D G L F L YD + L I++A L DF G +DPYVK++L
Sbjct: 216 QKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYL 275
Query: 134 LPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGE 193
LP K K +T+ R TLNP+++E + + D ++++ L +V D D+ S ++ IGE
Sbjct: 276 LPDRKK--KFQTRVHRKTLNPLFDETFQFP-VAYDQLSNRKLHFSVYDFDRFSRHDMIGE 332
Query: 194 IRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERG 253
+ L+ ++ S + + I C E + G
Sbjct: 333 V-----------------ILDNLFEVSDLSREATVWKDIHCATTESI----------DLG 365
Query: 254 RILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKT 313
I+ SL Y + + +++C +L AMD+ G SDPYVK L + + K KT KK T
Sbjct: 366 EIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNT 425
Query: 314 LNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCL 373
LNP +NE ++I + +L + V DYD N+ IG G A G R HW++ L
Sbjct: 426 LNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEML 485
Query: 374 QQPDAALERWHTLTSELPPAAGALSS 399
+ WH L ELP A + S
Sbjct: 486 AYHRKPITHWHPLL-ELPGRATSFDS 510
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 147 bits (372), Expect = 1e-35
Identities = 106/342 (30%), Positives = 154/342 (45%), Gaps = 31/342 (9%)
Query: 49 GGEAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHC 108
GGE A L+ G G S ++ G + F L Y S L
Sbjct: 259 GGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSDQLVV 318
Query: 109 SILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDD 168
IL+A L D NG +DPYVK++LLP K K +TK R TLNPV+NE +S +
Sbjct: 319 RILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRKTLNPVFNETFQFS-VPLA 375
Query: 169 DITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAA 228
++ + L +V D D+ S ++ IG++ L+ + LA
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQV-----------------VLDNLLELAEQPPDRPL 418
Query: 229 LRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSD 288
R I +G + G + SL Y L V I++ ++L AMD+ G+SD
Sbjct: 419 WRDIV----------EGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSD 468
Query: 289 PYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKS 348
PYVK L + + K KT +KK TLNP +NE +++ ++ L + V DYD
Sbjct: 469 PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGH 528
Query: 349 NDFIGGVSLGPGARG-EARKHWSDCLQQPDAALERWHTLTSE 389
N+ IG +GP A R+HW++ L P +E WH L E
Sbjct: 529 NEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEE 570
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 147 bits (372), Expect = 1e-35
Identities = 106/342 (30%), Positives = 154/342 (45%), Gaps = 31/342 (9%)
Query: 49 GGEAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHC 108
GGE A L+ G G S ++ G + F L Y S L
Sbjct: 259 GGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSDQLVV 318
Query: 109 SILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDD 168
IL+A L D NG +DPYVK++LLP K K +TK R TLNPV+NE +S +
Sbjct: 319 RILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRKTLNPVFNETFQFS-VPLA 375
Query: 169 DITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAA 228
++ + L +V D D+ S ++ IG++ L+ + LA
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQV-----------------VLDNLLELAEQPPDRPL 418
Query: 229 LRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSD 288
R I +G + G + SL Y L V I++ ++L AMD+ G+SD
Sbjct: 419 WRDIV----------EGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSD 468
Query: 289 PYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKS 348
PYVK L + + K KT +KK TLNP +NE +++ ++ L + V DYD
Sbjct: 469 PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGH 528
Query: 349 NDFIGGVSLGPGARG-EARKHWSDCLQQPDAALERWHTLTSE 389
N+ IG +GP A R+HW++ L P +E WH L E
Sbjct: 529 NEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEE 570
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 147 bits (372), Expect = 1e-35
Identities = 106/342 (30%), Positives = 154/342 (45%), Gaps = 31/342 (9%)
Query: 49 GGEAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHC 108
GGE A L+ G G S ++ G + F L Y S L
Sbjct: 259 GGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSDQLVV 318
Query: 109 SILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDD 168
IL+A L D NG +DPYVK++LLP K K +TK R TLNPV+NE +S +
Sbjct: 319 RILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRKTLNPVFNETFQFS-VPLA 375
Query: 169 DITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAA 228
++ + L +V D D+ S ++ IG++ L+ + LA
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQV-----------------VLDNLLELAEQPPDRPL 418
Query: 229 LRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSD 288
R I +G + G + SL Y L V I++ ++L AMD+ G+SD
Sbjct: 419 WRDIV----------EGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSD 468
Query: 289 PYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKS 348
PYVK L + + K KT +KK TLNP +NE +++ ++ L + V DYD
Sbjct: 469 PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGH 528
Query: 349 NDFIGGVSLGPGARG-EARKHWSDCLQQPDAALERWHTLTSE 389
N+ IG +GP A R+HW++ L P +E WH L E
Sbjct: 529 NEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEE 570
>gi|216548478 synaptotagmin XI [Homo sapiens]
Length = 431
Score = 140 bits (352), Expect = 3e-33
Identities = 99/319 (31%), Positives = 152/319 (47%), Gaps = 32/319 (10%)
Query: 72 TPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGL-ADPYVK 130
TP + ++ LG+L F + Y+ L +I A GL MD +DPY+K
Sbjct: 140 TPGESKTTSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIK 199
Query: 131 LHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEF 190
+ +LP K +++KT+ R TL+PV++E T+ GI + VL V D+ S ++
Sbjct: 200 MTILPD--KRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDV 257
Query: 191 IGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLE 250
IGE+ VPL + PS K + L R + R I +
Sbjct: 258 IGEVMVPLAGVDPSTGK---VQLTRDI----------IKRNIQKCIS------------- 291
Query: 251 ERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYS-DPYVKTYLRPDVDKKSKHKTCV 309
RG + +SLSY + + V +L+ HL MD+ G S +PYVK + + +K KT V
Sbjct: 292 -RGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHV 350
Query: 310 KKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGP-GARGEARKH 368
KK TLNP FNE F Y+I L ++E V D+D N+ +G + LG +H
Sbjct: 351 KKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTASGAEH 410
Query: 369 WSDCLQQPDAALERWHTLT 387
W + + P + +WH+L+
Sbjct: 411 WREVCESPRKPVAKWHSLS 429
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 140 bits (352), Expect = 3e-33
Identities = 100/315 (31%), Positives = 147/315 (46%), Gaps = 37/315 (11%)
Query: 81 SYDSDD-----ATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLP 135
S D+DD + A G L F L YD L I +A L DF+G +DPYVK++LLP
Sbjct: 207 SLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLP 266
Query: 136 GACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIR 195
+ K +TK R TLNPV++E + + +D+ + L +V D D+ S ++ IG++
Sbjct: 267 D--RKTKHQTKVHRKTLNPVFDEVFLFP-VPYNDLEARKLHFSVYDFDRFSRHDLIGQVV 323
Query: 196 VPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYL-KELEQAEQGQGLLEERGR 254
V HF + A C L K++E + G
Sbjct: 324 VD----------HF---------------LDLADFPRECILWKDIEYVTNDN---VDLGE 355
Query: 255 ILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTL 314
++ SL Y L + I++ +L AMD+ G SDPYVK L D + K KT K+ TL
Sbjct: 356 LMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTL 415
Query: 315 NPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQ 374
NP +NE +++ + L + V DYD N+ IG +G A R HWS+ L
Sbjct: 416 NPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWSEMLS 475
Query: 375 QPDAALERWHTLTSE 389
P + WH+L +
Sbjct: 476 YPRKPIAHWHSLVEK 490
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 124 bits (312), Expect = 1e-28
Identities = 95/315 (30%), Positives = 148/315 (46%), Gaps = 17/315 (5%)
Query: 55 HLVPL---ALAPPAALLGATTPEDGAEVDSY----DSDDATALGTLEFDLLYDRASCTLH 107
HLV L LA + G++ G+ + Y D + G + F L Y++ + +L
Sbjct: 315 HLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLV 374
Query: 108 CSILRAKGLKPMD-FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGIT 166
+ L D ++PYVK +LLP + K KT +R+T+NP+++E L Y I
Sbjct: 375 VHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IP 433
Query: 167 DDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMS 226
+ + + L+ +V + N F+GE + + K +K + L ++ SP+ +
Sbjct: 434 ESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLP 493
Query: 227 AALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGY 286
+ + LK + ++ G ++ + L V I +L A G
Sbjct: 494 SHKGELVVSLKYIPASKTPVGGDRKKSK-------GGEGGELQVWIKEAKNLTAAKAGGT 546
Query: 287 SDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYE-IELSTLATKTLEVTVWDYDI 345
SD +VK YL P +K SK KT V KKTLNP +N F Y + L L LE+TVWD +
Sbjct: 547 SDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREP 606
Query: 346 GKSNDFIGGVSLGPG 360
SNDF+GGV LG G
Sbjct: 607 LASNDFLGGVRLGVG 621
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 124 bits (312), Expect = 1e-28
Identities = 95/315 (30%), Positives = 148/315 (46%), Gaps = 17/315 (5%)
Query: 55 HLVPL---ALAPPAALLGATTPEDGAEVDSY----DSDDATALGTLEFDLLYDRASCTLH 107
HLV L LA + G++ G+ + Y D + G + F L Y++ + +L
Sbjct: 315 HLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLV 374
Query: 108 CSILRAKGLKPMD-FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGIT 166
+ L D ++PYVK +LLP + K KT +R+T+NP+++E L Y I
Sbjct: 375 VHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IP 433
Query: 167 DDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMS 226
+ + + L+ +V + N F+GE + + K +K + L ++ SP+ +
Sbjct: 434 ESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLP 493
Query: 227 AALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGY 286
+ + LK + ++ G ++ + L V I +L A G
Sbjct: 494 SHKGELVVSLKYIPASKTPVGGDRKKSK-------GGEGGELQVWIKEAKNLTAAKAGGT 546
Query: 287 SDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYE-IELSTLATKTLEVTVWDYDI 345
SD +VK YL P +K SK KT V KKTLNP +N F Y + L L LE+TVWD +
Sbjct: 547 SDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREP 606
Query: 346 GKSNDFIGGVSLGPG 360
SNDF+GGV LG G
Sbjct: 607 LASNDFLGGVRLGVG 621
>gi|40068038 B/K protein [Homo sapiens]
Length = 474
Score = 110 bits (275), Expect = 2e-24
Identities = 93/322 (28%), Positives = 146/322 (45%), Gaps = 43/322 (13%)
Query: 78 EVDSYDSDDATA---LGTLEFDLLYDRASCTLHCSILRAKGLKP-MDFNGL------ADP 127
+VDS ++ + LG L F YD L ++ A+ L P + +G ++P
Sbjct: 170 DVDSLTDEEILSKYQLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNP 229
Query: 128 YVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSH 187
YVK+ LLP + N +T +R T PV+ E T+ I + + L + V D DK S
Sbjct: 230 YVKICLLPD--QKNSKQTGVKRKTQKPVFEERYTFE-IPFLEAQRRTLLLTVVDFDKFSR 286
Query: 188 NEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQG 247
+ IG++ VPL + + H+ L PSS +
Sbjct: 287 HCVIGKVSVPLCEVDLVKGGHWWKAL-------IPSSQNEV------------------- 320
Query: 248 LLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKT 307
E G +LLSL+Y L V ++R L DV+ SDP+VK L + KT
Sbjct: 321 ---ELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKT 377
Query: 308 CVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEAR- 366
+ T++P +NE F +++ L +L TV+ +++ SNDFIG + +G + G +
Sbjct: 378 SFLRGTIDPFYNESFSFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSET 437
Query: 367 KHWSDCLQQPDAALERWHTLTS 388
HW L A+E+WH+L S
Sbjct: 438 NHWRRMLNTHRTAVEQWHSLRS 459
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 108 bits (271), Expect = 7e-24
Identities = 87/278 (31%), Positives = 129/278 (46%), Gaps = 27/278 (9%)
Query: 126 DPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKL 185
D YVK +LLP + NK KTK + T NP +NE L Y+ I+ + + L+++V D+
Sbjct: 444 DAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 501
Query: 186 SHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASP------SSMSAALRGISCYLKEL 239
N F+GE+ +P L+ +V A ++ LR I +
Sbjct: 502 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLM 561
Query: 240 EQAEQGQGLLE-ERGRILLSLSYSSRRRGLL-VGILRCAHLAAMDVNGYSDPYVKTYLRP 297
EQ QG ++G+ S S G+L V I +L A+ G SD +VK YL P
Sbjct: 562 LPPEQLQGNKTFKKGKKKESPVISG---GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 618
Query: 298 DVDKKSKHKTCVKKKTLNPEFNEEFFYE-IELSTLATKTLEVTVWDYDIGKSNDFIGGVS 356
D K +KHKT V KK++NP++N F + I + LE+T+WD + SN F+GGV
Sbjct: 619 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 678
Query: 357 LGPG-------------ARGEARKHWSDCLQQPDAALE 381
L G ++GE ++ W P E
Sbjct: 679 LNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFE 716
Score = 80.1 bits (196), Expect = 3e-15
Identities = 45/112 (40%), Positives = 65/112 (58%), Gaps = 2/112 (1%)
Query: 247 GLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGY-SDPYVKTYLRPDVDKKSKH 305
G ++ G ILL +SY + GL + + C +LA D +D YVK+YL PD + +K
Sbjct: 402 GNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKR 461
Query: 306 KTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSL 357
KT ++ T NPEFNE Y I + L T+TL+++VW YD N F+G V +
Sbjct: 462 KTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEI 512
Score = 63.5 bits (153), Expect = 3e-10
Identities = 33/91 (36%), Positives = 49/91 (53%)
Query: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165
L I AK L + G +D +VK +LLP KA K KT + ++NP WN +SGI
Sbjct: 589 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 648
Query: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRV 196
DI + L + + D++ S N F+G +R+
Sbjct: 649 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 108 bits (271), Expect = 7e-24
Identities = 87/278 (31%), Positives = 129/278 (46%), Gaps = 27/278 (9%)
Query: 126 DPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKL 185
D YVK +LLP + NK KTK + T NP +NE L Y+ I+ + + L+++V D+
Sbjct: 466 DAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 523
Query: 186 SHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASP------SSMSAALRGISCYLKEL 239
N F+GE+ +P L+ +V A ++ LR I +
Sbjct: 524 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLM 583
Query: 240 EQAEQGQGLLE-ERGRILLSLSYSSRRRGLL-VGILRCAHLAAMDVNGYSDPYVKTYLRP 297
EQ QG ++G+ S S G+L V I +L A+ G SD +VK YL P
Sbjct: 584 LPPEQLQGNKTFKKGKKKESPVISG---GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 640
Query: 298 DVDKKSKHKTCVKKKTLNPEFNEEFFYE-IELSTLATKTLEVTVWDYDIGKSNDFIGGVS 356
D K +KHKT V KK++NP++N F + I + LE+T+WD + SN F+GGV
Sbjct: 641 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 700
Query: 357 LGPG-------------ARGEARKHWSDCLQQPDAALE 381
L G ++GE ++ W P E
Sbjct: 701 LNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFE 738
Score = 80.1 bits (196), Expect = 3e-15
Identities = 45/112 (40%), Positives = 65/112 (58%), Gaps = 2/112 (1%)
Query: 247 GLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGY-SDPYVKTYLRPDVDKKSKH 305
G ++ G ILL +SY + GL + + C +LA D +D YVK+YL PD + +K
Sbjct: 424 GNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKR 483
Query: 306 KTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSL 357
KT ++ T NPEFNE Y I + L T+TL+++VW YD N F+G V +
Sbjct: 484 KTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEI 534
Score = 63.5 bits (153), Expect = 3e-10
Identities = 33/91 (36%), Positives = 49/91 (53%)
Query: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165
L I AK L + G +D +VK +LLP KA K KT + ++NP WN +SGI
Sbjct: 611 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 670
Query: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRV 196
DI + L + + D++ S N F+G +R+
Sbjct: 671 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 701
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 108 bits (271), Expect = 7e-24
Identities = 87/278 (31%), Positives = 129/278 (46%), Gaps = 27/278 (9%)
Query: 126 DPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKL 185
D YVK +LLP + NK KTK + T NP +NE L Y+ I+ + + L+++V D+
Sbjct: 444 DAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 501
Query: 186 SHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASP------SSMSAALRGISCYLKEL 239
N F+GE+ +P L+ +V A ++ LR I +
Sbjct: 502 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLM 561
Query: 240 EQAEQGQGLLE-ERGRILLSLSYSSRRRGLL-VGILRCAHLAAMDVNGYSDPYVKTYLRP 297
EQ QG ++G+ S S G+L V I +L A+ G SD +VK YL P
Sbjct: 562 LPPEQLQGNKTFKKGKKKESPVISG---GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 618
Query: 298 DVDKKSKHKTCVKKKTLNPEFNEEFFYE-IELSTLATKTLEVTVWDYDIGKSNDFIGGVS 356
D K +KHKT V KK++NP++N F + I + LE+T+WD + SN F+GGV
Sbjct: 619 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 678
Query: 357 LGPG-------------ARGEARKHWSDCLQQPDAALE 381
L G ++GE ++ W P E
Sbjct: 679 LNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFE 716
Score = 80.1 bits (196), Expect = 3e-15
Identities = 45/112 (40%), Positives = 65/112 (58%), Gaps = 2/112 (1%)
Query: 247 GLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGY-SDPYVKTYLRPDVDKKSKH 305
G ++ G ILL +SY + GL + + C +LA D +D YVK+YL PD + +K
Sbjct: 402 GNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKR 461
Query: 306 KTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSL 357
KT ++ T NPEFNE Y I + L T+TL+++VW YD N F+G V +
Sbjct: 462 KTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEI 512
Score = 63.5 bits (153), Expect = 3e-10
Identities = 33/91 (36%), Positives = 49/91 (53%)
Query: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165
L I AK L + G +D +VK +LLP KA K KT + ++NP WN +SGI
Sbjct: 589 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 648
Query: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRV 196
DI + L + + D++ S N F+G +R+
Sbjct: 649 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679
>gi|123173752 synaptotagmin XIV-like [Homo sapiens]
Length = 645
Score = 108 bits (269), Expect = 1e-23
Identities = 85/312 (27%), Positives = 150/312 (48%), Gaps = 11/312 (3%)
Query: 78 EVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGA 137
+V S S+ + G L+ Y AS L +I+RA+GL D +G+ V + LLPG
Sbjct: 339 QVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPG- 397
Query: 138 CKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVP 197
K ++ +T QR NPV+ E +T++ + D+ +R + K++ +GE
Sbjct: 398 -KKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFY 455
Query: 198 LRRLKPSQKKHFNICLERQVPLASPSS-MSAALRGISCYLKELEQAEQGQGLLEERGRIL 256
L L P + + LE + ++S S +S + S + G +L
Sbjct: 456 LSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGA-----PELL 510
Query: 257 LSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKK-SKHKTCVKKKTLN 315
+ LSY++ L V +++ +H + VN D Y K +L V ++ S+ KT +++ N
Sbjct: 511 VGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPN 570
Query: 316 PEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARK-HWSDCLQ 374
P + E F +++ L L+ TL ++V++ K + IG ++LG + GE + HW + +
Sbjct: 571 PVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKE 630
Query: 375 QPDAALERWHTL 386
+ RWHTL
Sbjct: 631 TKGQQICRWHTL 642
>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
Length = 376
Score = 97.1 bits (240), Expect = 3e-20
Identities = 88/312 (28%), Positives = 139/312 (44%), Gaps = 28/312 (8%)
Query: 79 VDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGL-ADPYVKLHLLPGA 137
V S D + G ++F + Y + LH + + K L D +DPYVK +LLP
Sbjct: 60 VYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDK 119
Query: 138 CKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVP 197
K K KT + TLNPV+NE L Y I + + L +++ D N F+GE+ +
Sbjct: 120 GKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLSIWHRDTFKRNSFLGEVELD 178
Query: 198 LRRLKPSQKKHFNICLERQVPL---ASPSSMSAALRG-ISCYLKELEQAEQGQGLLEERG 253
L K++ + R PL +P ++ A RG + L+ + + G+ L G
Sbjct: 179 LETWDWDNKQNKQL---RWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGK-KLPTTG 234
Query: 254 RILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKT 313
+ + + + L + +LR +HL + +VK + PD +KS+ KT KT
Sbjct: 235 EVHIWV-----KECLDLPLLRGSHL---------NSFVKCTILPDTSRKSRQKTRAVGKT 280
Query: 314 LNPEFNEEFFYE-IELSTLATKTLEVTVWDYDIGKSNDFIGG--VSLGPGARGEARKHWS 370
NP FN Y+ L +E+TVWD+ +N F+GG + G G W
Sbjct: 281 TNPIFNHTMVYDGFRPEDLMEACVELTVWDH-YKLTNQFLGGLRIGFGTGKSYGTEVDWM 339
Query: 371 DCLQQPDAALER 382
D + A E+
Sbjct: 340 DSTSEEVALWEK 351
Score = 91.3 bits (225), Expect = 1e-18
Identities = 58/144 (40%), Positives = 76/144 (52%), Gaps = 7/144 (4%)
Query: 221 SPSSM-----SAALRGISCYLKELEQAEQGQ-GLLEERGRILLSLSYSSRRRGLLVGILR 274
SPSS+ S+ + +S + G G LE +G I ++ Y + L V + +
Sbjct: 34 SPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQ 93
Query: 275 CAHLAAMDVNGY-SDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLAT 333
C LAA DV SDPYVK YL PD K K KT V KKTLNP +NE Y+IE L T
Sbjct: 94 CKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKT 153
Query: 334 KTLEVTVWDYDIGKSNDFIGGVSL 357
+ L +++W D K N F+G V L
Sbjct: 154 QKLNLSIWHRDTFKRNSFLGEVEL 177
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,406,680
Number of Sequences: 37866
Number of extensions: 893271
Number of successful extensions: 6157
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 5075
Number of HSP's gapped (non-prelim): 794
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.