Guide to the Human Genome
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Search of human proteins with 45827802

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45827802 prestin isoform c [Homo sapiens]
         (516 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45827802 prestin isoform c [Homo sapiens]                         1013   0.0  
gi|45827800 prestin isoform b [Homo sapiens]                          987   0.0  
gi|39752683 prestin isoform a [Homo sapiens]                          987   0.0  
gi|45827804 prestin isoform d [Homo sapiens]                          642   0.0  
gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo s...   450   e-126
gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo s...   450   e-126
gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo s...   450   e-126
gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo s...   449   e-126
gi|4505697 pendrin [Homo sapiens]                                     438   e-123
gi|4557535 solute carrier family 26, member 3 [Homo sapiens]          429   e-120
gi|16418413 solute carrier family 26, member 9 isoform a [Homo s...   388   e-108
gi|217272867 solute carrier family 26, member 9 isoform b [Homo ...   388   e-108
gi|100913030 solute carrier family 26 member 2 [Homo sapiens]         378   e-105
gi|47131207 solute carrier family 26, member 1 isoform a [Homo s...   335   5e-92
gi|20336272 solute carrier family 26, member 1 isoform a [Homo s...   335   5e-92
gi|16306483 solute carrier family 26, member 7 isoform a [Homo s...   293   3e-79
gi|20336282 solute carrier family 26, member 7 isoform b [Homo s...   293   3e-79
gi|65506789 solute carrier family 26, member 10 [Homo sapiens]        258   9e-69
gi|16418457 solute carrier family 26, member 8 isoform a [Homo s...   248   1e-65
gi|85540447 solute carrier family 26, member 11 [Homo sapiens]        182   5e-46
gi|217272870 solute carrier family 26, member 9 isoform c [Homo ...   152   5e-37
gi|20336285 solute carrier family 26, member 8 isoform b [Homo s...   136   5e-32
gi|20336274 solute carrier family 26, member 1 isoform b [Homo s...   109   5e-24
gi|45827778 reticulon 1 isoform B [Homo sapiens]                       30   6.9  
gi|45827776 reticulon 1 isoform C [Homo sapiens]                       30   6.9  
gi|10863935 reticulon 1 isoform A [Homo sapiens]                       30   6.9  

>gi|45827802 prestin isoform c [Homo sapiens]
          Length = 516

 Score = 1013 bits (2619), Expect = 0.0
 Identities = 516/516 (100%), Positives = 516/516 (100%)

Query: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60
           MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
Sbjct: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60

Query: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120
           IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
Sbjct: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120

Query: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180
           IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
Sbjct: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180

Query: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240
           SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
Sbjct: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240

Query: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300
           FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
Sbjct: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300

Query: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360
           TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
Sbjct: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360

Query: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420
           LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
Sbjct: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420

Query: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480
           ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
Sbjct: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480

Query: 481 FLGLDYGLITAVIIALLTVIYRTQSFHTEMTRRWRP 516
           FLGLDYGLITAVIIALLTVIYRTQSFHTEMTRRWRP
Sbjct: 481 FLGLDYGLITAVIIALLTVIYRTQSFHTEMTRRWRP 516


>gi|45827800 prestin isoform b [Homo sapiens]
          Length = 685

 Score =  987 bits (2552), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60
           MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
Sbjct: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60

Query: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120
           IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
Sbjct: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120

Query: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180
           IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
Sbjct: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180

Query: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240
           SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
Sbjct: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240

Query: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300
           FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
Sbjct: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300

Query: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360
           TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
Sbjct: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360

Query: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420
           LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
Sbjct: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420

Query: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480
           ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
Sbjct: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480

Query: 481 FLGLDYGLITAVIIALLTVIYRTQS 505
           FLGLDYGLITAVIIALLTVIYRTQS
Sbjct: 481 FLGLDYGLITAVIIALLTVIYRTQS 505


>gi|39752683 prestin isoform a [Homo sapiens]
          Length = 744

 Score =  987 bits (2552), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60
           MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
Sbjct: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60

Query: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120
           IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
Sbjct: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120

Query: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180
           IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
Sbjct: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180

Query: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240
           SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
Sbjct: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240

Query: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300
           FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
Sbjct: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300

Query: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360
           TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
Sbjct: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360

Query: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420
           LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
Sbjct: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420

Query: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480
           ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
Sbjct: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480

Query: 481 FLGLDYGLITAVIIALLTVIYRTQS 505
           FLGLDYGLITAVIIALLTVIYRTQS
Sbjct: 481 FLGLDYGLITAVIIALLTVIYRTQS 505


>gi|45827804 prestin isoform d [Homo sapiens]
          Length = 335

 Score =  642 bits (1656), Expect = 0.0
 Identities = 324/324 (100%), Positives = 324/324 (100%)

Query: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60
           MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
Sbjct: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60

Query: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120
           IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
Sbjct: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120

Query: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180
           IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
Sbjct: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180

Query: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240
           SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
Sbjct: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240

Query: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300
           FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
Sbjct: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300

Query: 301 TGISAGFNLKESYNVDVVGTLPLG 324
           TGISAGFNLKESYNVDVVGTLPLG
Sbjct: 301 TGISAGFNLKESYNVDVVGTLPLG 324



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 11/11 (100%), Positives = 11/11 (100%)

Query: 506 FHTEMTRRWRP 516
           FHTEMTRRWRP
Sbjct: 325 FHTEMTRRWRP 335


>gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo
           sapiens]
          Length = 740

 Score =  450 bits (1158), Expect = e-126
 Identities = 236/506 (46%), Positives = 334/506 (66%), Gaps = 15/506 (2%)

Query: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71

Query: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131

Query: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186

Query: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246

Query: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306

Query: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366

Query: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426

Query: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486

Query: 482 LGLDYGLITAVIIALLTVIYRTQSFH 507
           L LD GL+ AVI +LL V+ RTQ  H
Sbjct: 487 LNLDLGLVVAVIFSLLLVVVRTQMPH 512


>gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo
           sapiens]
          Length = 758

 Score =  450 bits (1158), Expect = e-126
 Identities = 236/506 (46%), Positives = 334/506 (66%), Gaps = 15/506 (2%)

Query: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71

Query: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131

Query: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186

Query: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246

Query: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306

Query: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366

Query: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426

Query: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486

Query: 482 LGLDYGLITAVIIALLTVIYRTQSFH 507
           L LD GL+ AVI +LL V+ RTQ  H
Sbjct: 487 LNLDLGLVVAVIFSLLLVVVRTQMPH 512


>gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo
           sapiens]
          Length = 759

 Score =  450 bits (1158), Expect = e-126
 Identities = 236/506 (46%), Positives = 334/506 (66%), Gaps = 15/506 (2%)

Query: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71

Query: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131

Query: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186

Query: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246

Query: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306

Query: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366

Query: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426

Query: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486

Query: 482 LGLDYGLITAVIIALLTVIYRTQSFH 507
           L LD GL+ AVI +LL V+ RTQ  H
Sbjct: 487 LNLDLGLVVAVIFSLLLVVVRTQMPH 512


>gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo
           sapiens]
          Length = 738

 Score =  449 bits (1156), Expect = e-126
 Identities = 232/492 (47%), Positives = 328/492 (66%), Gaps = 8/492 (1%)

Query: 16  YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYK 75
           Y++ERP+ +   L+E L      P +   + +    C+  +   ++   LP+  WLP Y 
Sbjct: 8   YHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALLLQHLPVLVWLPRYP 64

Query: 76  FKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIG 135
            ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV +Y   GTSRHIS+G
Sbjct: 65  VRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVG 124

Query: 136 PFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGV 195
            FAV+S+M+G V   L P  +     +N T    ARDA RV+VA ++++L G+ Q  LG+
Sbjct: 125 TFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVASTLSVLVGLFQVGLGL 179

Query: 196 CRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVK 255
             FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  S++Y+ + V   + 
Sbjct: 180 IHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLP 239

Query: 256 NLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNV 315
              V ++    +   +L+  K  N++ +++LP PIP E   ++  TGIS G  LK  + V
Sbjct: 240 QSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEV 299

Query: 316 DVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQEL 375
           DVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  A +HGY+VD NQEL
Sbjct: 300 DVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQEL 359

Query: 376 IALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESL 435
           +ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL ILL+I+  G LF  L
Sbjct: 360 VALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDL 419

Query: 436 PQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIA 495
           P+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ L LD GL+ AVI +
Sbjct: 420 PKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFS 479

Query: 496 LLTVIYRTQSFH 507
           LL V+ RTQ  H
Sbjct: 480 LLLVVVRTQMPH 491


>gi|4505697 pendrin [Homo sapiens]
          Length = 780

 Score =  438 bits (1126), Expect = e-123
 Identities = 211/495 (42%), Positives = 318/495 (64%), Gaps = 6/495 (1%)

Query: 16  YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYK 75
           Y V RP++S    Q++   + +   ++ + L +  +C+ K+   ++   +PI +WLP Y+
Sbjct: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79

Query: 76  FKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIG 135
            KE++L D++SG+STG++   QG+A+A+LAAVP  +GLYS+F+P++ Y   GTSRHIS+G
Sbjct: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139

Query: 136 PFAVISLMIGGVAVRLVPDDIVIPGGVNATN------GTEARDALRVKVAMSVTLLSGII 189
           PF V+SLM+G V + + PD+  +    N T        T ARD  RV +A ++TLL GII
Sbjct: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199

Query: 190 QFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVA 249
           Q   G  + GF+  YL +PLV GFTTAAA  V  S LK +  V TK Y+G+ S++Y+ V 
Sbjct: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259

Query: 250 VLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNL 309
           + QN+ + N+     GL+   + +  KE N+RF+ K+P PIP+E    ++ T IS G NL
Sbjct: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319

Query: 310 KESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQV 369
           +++YN  +V ++P G LPP  P  SLF  +   + +IA+V +++ +S+ K  A K+ Y +
Sbjct: 320 EKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTI 379

Query: 370 DGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATG 429
           DGNQE IA G+ N     F  F  + +LSR+ VQE TGGKTQ+AG +++ ++++ ILA G
Sbjct: 380 DGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439

Query: 430 FLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLI 489
            L E L ++VL+A+VI NLKGMFMQ  D+P  WR +KI+  IW+ T + S+ LGLD GL+
Sbjct: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLL 499

Query: 490 TAVIIALLTVIYRTQ 504
             +I  LLTV+ R Q
Sbjct: 500 AGLIFGLLTVVLRVQ 514


>gi|4557535 solute carrier family 26, member 3 [Homo sapiens]
          Length = 764

 Score =  429 bits (1104), Expect = e-120
 Identities = 224/500 (44%), Positives = 319/500 (63%), Gaps = 13/500 (2%)

Query: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74
           +Y V RP++S    +E      +   +  D LK   +C+P+K + I+    PI  WLPAY
Sbjct: 8   QYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAY 67

Query: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134
           + KE++L D+VSGISTG++ + QGLAFA+L  +PP++GLY+SF+P I+Y F GTSRHIS+
Sbjct: 68  RLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISV 127

Query: 135 GPFAVISLMIG----GVAVRLVPDDIVIPGGV-NATNGTEARDALRVKVAM--SVTLLSG 187
           GPF ++S+M+G    G   + VPD      G+ N +N +   D  RV+VA   SVT+LSG
Sbjct: 128 GPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSG 187

Query: 188 IIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYS---GIFSVV 244
           IIQ   G+ R GFV IYL+E L+ GFTTAAAVHV  S LK++F +    ++    IF V+
Sbjct: 188 IIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVL 247

Query: 245 YSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGIS 304
           YS   V   ++  N+  L   L+V  ++   KE N+RFK+KLP PIP+EF   V+  G+S
Sbjct: 248 YS---VFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVS 304

Query: 305 AGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANK 364
            G + K  + V VVG +  G  PP  PD   F     D   IA+V F+V  S+A   + K
Sbjct: 305 YGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLK 364

Query: 365 HGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLV 424
           + Y +DGNQELIALGL N +  +F+ F+ S +LSRS VQE TGGKTQ+AG + ++++L+V
Sbjct: 365 YDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIV 424

Query: 425 ILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGL 484
           +LA GFL   L ++VL+A+ + NLKGM MQF+++   WR  K +  IW+ TF+ ++ LGL
Sbjct: 425 VLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGL 484

Query: 485 DYGLITAVIIALLTVIYRTQ 504
             GL  +V   LLT+++RTQ
Sbjct: 485 GLGLAASVAFQLLTIVFRTQ 504


>gi|16418413 solute carrier family 26, member 9 isoform a [Homo
           sapiens]
          Length = 791

 Score =  388 bits (996), Expect = e-108
 Identities = 197/494 (39%), Positives = 307/494 (62%), Gaps = 6/494 (1%)

Query: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74
           RY V+R  +S  +  +    KD+    + +KL+ AF C+  KI+ +++  LP+  WLP Y
Sbjct: 7   RYVVDRAAYSLTLFDDEFEKKDRTYP-VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65

Query: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134
           K K+Y++ DL+ G+S G +Q+PQG+AFA+LA +P + GLYSSF+P++ Y FLG    +  
Sbjct: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125

Query: 135 GPFAVISLMIGGVAVRLVPDDIVIPGGVNATN----GTEARDALRVKVAMSVTLLSGIIQ 190
           G FAVIS+++G + ++L P+        NATN     T A +A R+ V+ ++  L+ IIQ
Sbjct: 126 GTFAVISILVGNICLQLAPESKFQVFN-NATNESYVDTAAMEAERLHVSATLACLTAIIQ 184

Query: 191 FCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAV 250
             LG  +FGFVAIYL+E  +RGF TAA + +  S+LKY+FG+    Y+G  S+V++ + +
Sbjct: 185 MGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDI 244

Query: 251 LQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLK 310
            +N+ + N+ SL   L+    L+  KE N R+  K+  PIP E   VV+ T IS G  + 
Sbjct: 245 CKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMP 304

Query: 311 ESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVD 370
           + Y++ +VG +  G   P +P  S +  +   A ++AIV + + ++M +TLANKHGY VD
Sbjct: 305 KKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVD 364

Query: 371 GNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGF 430
            NQE+IALG  N  GS F+   I C+LS +L  +G GGK+Q+A    SL++++ +L  G 
Sbjct: 365 SNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGI 424

Query: 431 LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLIT 490
               LP++VL A++ VNLK    Q +D  + WR SK++  IW+ +F+SS FL L YG+  
Sbjct: 425 YLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAV 484

Query: 491 AVIIALLTVIYRTQ 504
            V  ++L V+++TQ
Sbjct: 485 GVAFSVLVVVFQTQ 498


>gi|217272867 solute carrier family 26, member 9 isoform b [Homo
           sapiens]
          Length = 887

 Score =  388 bits (996), Expect = e-108
 Identities = 197/494 (39%), Positives = 307/494 (62%), Gaps = 6/494 (1%)

Query: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74
           RY V+R  +S  +  +    KD+    + +KL+ AF C+  KI+ +++  LP+  WLP Y
Sbjct: 7   RYVVDRAAYSLTLFDDEFEKKDRTYP-VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65

Query: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134
           K K+Y++ DL+ G+S G +Q+PQG+AFA+LA +P + GLYSSF+P++ Y FLG    +  
Sbjct: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125

Query: 135 GPFAVISLMIGGVAVRLVPDDIVIPGGVNATN----GTEARDALRVKVAMSVTLLSGIIQ 190
           G FAVIS+++G + ++L P+        NATN     T A +A R+ V+ ++  L+ IIQ
Sbjct: 126 GTFAVISILVGNICLQLAPESKFQVFN-NATNESYVDTAAMEAERLHVSATLACLTAIIQ 184

Query: 191 FCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAV 250
             LG  +FGFVAIYL+E  +RGF TAA + +  S+LKY+FG+    Y+G  S+V++ + +
Sbjct: 185 MGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDI 244

Query: 251 LQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLK 310
            +N+ + N+ SL   L+    L+  KE N R+  K+  PIP E   VV+ T IS G  + 
Sbjct: 245 CKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMP 304

Query: 311 ESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVD 370
           + Y++ +VG +  G   P +P  S +  +   A ++AIV + + ++M +TLANKHGY VD
Sbjct: 305 KKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVD 364

Query: 371 GNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGF 430
            NQE+IALG  N  GS F+   I C+LS +L  +G GGK+Q+A    SL++++ +L  G 
Sbjct: 365 SNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGI 424

Query: 431 LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLIT 490
               LP++VL A++ VNLK    Q +D  + WR SK++  IW+ +F+SS FL L YG+  
Sbjct: 425 YLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAV 484

Query: 491 AVIIALLTVIYRTQ 504
            V  ++L V+++TQ
Sbjct: 485 GVAFSVLVVVFQTQ 498


>gi|100913030 solute carrier family 26 member 2 [Homo sapiens]
          Length = 739

 Score =  378 bits (970), Expect = e-105
 Identities = 199/496 (40%), Positives = 297/496 (59%), Gaps = 16/496 (3%)

Query: 25  HPVLQERLHTKD-KVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGD 83
           H +L ER    D    + +  KL++   C+P K +N+I  FLP+ +WLP Y  K+ +LGD
Sbjct: 52  HRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGD 111

Query: 84  LVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLM 143
           ++SG+  G+L +PQ +A+++LA   P++GLY+SF+  I+Y  LGTSRHIS+G F V+ LM
Sbjct: 112 VMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCLM 171

Query: 144 IGGVAVRLV-----------PDDIVIPGGVNATNGTEAR----DALRVKVAMSVTLLSGI 188
           IG    R +           P   ++  G    N T  R        + V  +VT ++G+
Sbjct: 172 IGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGV 231

Query: 189 IQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTV 248
            Q  +G  + GFV++YL++ L+ GF T A+  + TS  KYL G+   R +G+ S++ + +
Sbjct: 232 YQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWI 291

Query: 249 AVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFN 308
            V +N+   N+C L   L+   +LL  KE NE FK KL APIP+E   VV  T  S    
Sbjct: 292 HVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFGK 351

Query: 309 LKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQ 368
           L E+YN  + G +P G +PP  P+ +L   V VDAIAI+I+GF++T+S+++  A KHGY 
Sbjct: 352 LHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYT 411

Query: 369 VDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILAT 428
           V  NQE+ A+G CN I S F  F+ S +L+++LV+E TG  TQL+G + +L++LLV+L  
Sbjct: 412 VKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVI 471

Query: 429 GFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGL 488
             LF SL ++VL  I IVNL+G   +F DLP  W  S+++  IW  T +SS  L  + GL
Sbjct: 472 APLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGL 531

Query: 489 ITAVIIALLTVIYRTQ 504
           +  V  ++  VI RTQ
Sbjct: 532 LVGVCFSIFCVILRTQ 547


>gi|47131207 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  335 bits (860), Expect = 5e-92
 Identities = 170/476 (35%), Positives = 292/476 (61%), Gaps = 13/476 (2%)

Query: 51  TCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPI 110
           +C+   +R ++   LP T+WL  Y+ +EY+ GD++SG+  G++ +PQ +A+++LA + PI
Sbjct: 40  SCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPI 99

Query: 111 FGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVP-------DDIVIPGGVN 163
           + LY+SF+  ++Y  +GTSRH+S+G F+++ LM+G V  R +         D + PG  +
Sbjct: 100 YSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANS 159

Query: 164 AT-NGTEA-----RDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAA 217
           +T NG+ A     RD   ++VA ++TL++G+ Q  +GV R GFV+ YL++PL+ GF   A
Sbjct: 160 STLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGA 219

Query: 218 AVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKE 277
           +V + TS LK+L GV+  R+ G   VV + +++L+     NVC +    +   +LL  KE
Sbjct: 220 SVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKE 279

Query: 278 FNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFH 337
            ++R++ +L  P+P E   +V+ T +S    L + +   V G +P G +PP  P+  L  
Sbjct: 280 LSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQ 339

Query: 338 LVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSL 397
            V +DA+A+A+V  + +IS+A+  A  HGY V  NQEL+A+G CN + +    F+ S +L
Sbjct: 340 RVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAAL 399

Query: 398 SRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSD 457
           ++SLV+  TG +TQL+  +++ ++LLV+LA   LF  L ++VL+ +++V+L+G   +  D
Sbjct: 400 AKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWD 459

Query: 458 LPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSFHTEMTRR 513
           LP  WR S  +  +W  T  + + +  + GL+  VI++LL++  RTQ   T +  R
Sbjct: 460 LPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLAR 515


>gi|20336272 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  335 bits (860), Expect = 5e-92
 Identities = 170/476 (35%), Positives = 292/476 (61%), Gaps = 13/476 (2%)

Query: 51  TCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPI 110
           +C+   +R ++   LP T+WL  Y+ +EY+ GD++SG+  G++ +PQ +A+++LA + PI
Sbjct: 40  SCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPI 99

Query: 111 FGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVP-------DDIVIPGGVN 163
           + LY+SF+  ++Y  +GTSRH+S+G F+++ LM+G V  R +         D + PG  +
Sbjct: 100 YSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANS 159

Query: 164 AT-NGTEA-----RDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAA 217
           +T NG+ A     RD   ++VA ++TL++G+ Q  +GV R GFV+ YL++PL+ GF   A
Sbjct: 160 STLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGA 219

Query: 218 AVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKE 277
           +V + TS LK+L GV+  R+ G   VV + +++L+     NVC +    +   +LL  KE
Sbjct: 220 SVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKE 279

Query: 278 FNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFH 337
            ++R++ +L  P+P E   +V+ T +S    L + +   V G +P G +PP  P+  L  
Sbjct: 280 LSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQ 339

Query: 338 LVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSL 397
            V +DA+A+A+V  + +IS+A+  A  HGY V  NQEL+A+G CN + +    F+ S +L
Sbjct: 340 RVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAAL 399

Query: 398 SRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSD 457
           ++SLV+  TG +TQL+  +++ ++LLV+LA   LF  L ++VL+ +++V+L+G   +  D
Sbjct: 400 AKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWD 459

Query: 458 LPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSFHTEMTRR 513
           LP  WR S  +  +W  T  + + +  + GL+  VI++LL++  RTQ   T +  R
Sbjct: 460 LPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLAR 515


>gi|16306483 solute carrier family 26, member 7 isoform a [Homo
           sapiens]
          Length = 656

 Score =  293 bits (750), Expect = 3e-79
 Identities = 155/440 (35%), Positives = 249/440 (56%), Gaps = 2/440 (0%)

Query: 65  LPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYC 124
           LPI  W P Y  KE +L D VSGI   V Q+ QGLAFA+L++V P+FGLY S +P I+Y 
Sbjct: 32  LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91

Query: 125 FLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATNGTEARDALRVKVAMSV 182
             G   H++ G FA+ SL+      R+VP ++  +      +  G    +  R+ VA +V
Sbjct: 92  IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAV 151

Query: 183 TLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFS 242
           + L G+IQ  + V + G     +TEP++   TT AA HV TS +KYL G+K    SG   
Sbjct: 152 SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLG 211

Query: 243 VVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTG 302
             Y    V +N+K++ + +L + L+   +L+  KE NE+FK K+   +P++   ++  + 
Sbjct: 212 FFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271

Query: 303 ISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLA 362
                N++ +Y ++VVG +P G+  P  P  ++   V  +A  +A+VG+  ++++A+  A
Sbjct: 272 ACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSA 331

Query: 363 NKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMIL 422
            K  Y +D NQE +A GL N + S F     + ++ R+     TG KTQ+A  ++ + +L
Sbjct: 332 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL 391

Query: 423 LVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFL 482
           +VI A G L   LP  VL++I++V LKGM +QF DL  +W   KI+  IW++T+V ++  
Sbjct: 392 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF 451

Query: 483 GLDYGLITAVIIALLTVIYR 502
             + GL+  V+  +  VI R
Sbjct: 452 AANVGLLFGVVCTIAIVIGR 471


>gi|20336282 solute carrier family 26, member 7 isoform b [Homo
           sapiens]
          Length = 663

 Score =  293 bits (750), Expect = 3e-79
 Identities = 155/440 (35%), Positives = 249/440 (56%), Gaps = 2/440 (0%)

Query: 65  LPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYC 124
           LPI  W P Y  KE +L D VSGI   V Q+ QGLAFA+L++V P+FGLY S +P I+Y 
Sbjct: 32  LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91

Query: 125 FLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATNGTEARDALRVKVAMSV 182
             G   H++ G FA+ SL+      R+VP ++  +      +  G    +  R+ VA +V
Sbjct: 92  IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAV 151

Query: 183 TLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFS 242
           + L G+IQ  + V + G     +TEP++   TT AA HV TS +KYL G+K    SG   
Sbjct: 152 SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLG 211

Query: 243 VVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTG 302
             Y    V +N+K++ + +L + L+   +L+  KE NE+FK K+   +P++   ++  + 
Sbjct: 212 FFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271

Query: 303 ISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLA 362
                N++ +Y ++VVG +P G+  P  P  ++   V  +A  +A+VG+  ++++A+  A
Sbjct: 272 ACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSA 331

Query: 363 NKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMIL 422
            K  Y +D NQE +A GL N + S F     + ++ R+     TG KTQ+A  ++ + +L
Sbjct: 332 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL 391

Query: 423 LVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFL 482
           +VI A G L   LP  VL++I++V LKGM +QF DL  +W   KI+  IW++T+V ++  
Sbjct: 392 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF 451

Query: 483 GLDYGLITAVIIALLTVIYR 502
             + GL+  V+  +  VI R
Sbjct: 452 AANVGLLFGVVCTIAIVIGR 471


>gi|65506789 solute carrier family 26, member 10 [Homo sapiens]
          Length = 563

 Score =  258 bits (659), Expect = 9e-69
 Identities = 142/374 (37%), Positives = 221/374 (59%), Gaps = 3/374 (0%)

Query: 98  GLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIV 157
           G+AFA+LA+VPP+FGLY+SF+PV++Y  LGT RH+S G FA++SLM G    RLVP+ +V
Sbjct: 41  GMAFALLASVPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILSLMTGSAVERLVPEPLV 100

Query: 158 IPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAA 217
             G ++     E  DA RV VA +V   SG +   + V + G ++ +L+EP+V+  T+ A
Sbjct: 101 --GNLSGIE-KEQLDAQRVGVAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVVKALTSGA 157

Query: 218 AVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKE 277
           A+HV  S L  L G+   R  G FS+  +  ++L  +   +   L +  +   LL+  KE
Sbjct: 158 ALHVLLSQLPSLLGLSLPRQIGCFSLFKTLASLLTALPRSSPAELTISALSLALLVPVKE 217

Query: 278 FNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFH 337
            N RF+++LP PIP E   V++ + +    ++   Y V +VG LP G   P  P+ +   
Sbjct: 218 LNVRFRDRLPTPIPGEVVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQPLLPNLAELP 277

Query: 338 LVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSL 397
            +  D++ IA+V F+V+ S+A   A+K+ Y +D NQE +A G  N I SLF  F  S +L
Sbjct: 278 RILADSLPIALVSFAVSASLASIHADKYSYTIDSNQEFLAHGASNLISSLFSCFPNSATL 337

Query: 398 SRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSD 457
           + + +    GGKTQLAG  +  ++L V+L  G  F  LP+AVL+ I I +++ +F Q  +
Sbjct: 338 ATTNLLVDAGGKTQLAGLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSMRQVFCQMQE 397

Query: 458 LPFFWRTSKIELTI 471
           LP  W  S+++  +
Sbjct: 398 LPQLWHISRVDFLL 411


>gi|16418457 solute carrier family 26, member 8 isoform a [Homo
           sapiens]
          Length = 970

 Score =  248 bits (632), Expect = 1e-65
 Identities = 141/460 (30%), Positives = 247/460 (53%), Gaps = 10/460 (2%)

Query: 52  CTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAA--VPP 109
           C+  +    +    P  +W+  Y+ K+++LGDL++GIS G++Q+PQGL  ++LA   +PP
Sbjct: 64  CSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPP 123

Query: 110 IFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIGGVAVRLVPDDIVIPGGVNATNGT 168
           +   Y++F   ++Y   G+   +SIG F ++S L+I  + V    +  ++ G     N  
Sbjct: 124 LNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSF-VKNEF 182

Query: 169 EARDALR-----VKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFT 223
            A   L      + V  + T L+GIIQ  +GV   GF+A YL E  +  +  A A+H+  
Sbjct: 183 SAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIML 242

Query: 224 SMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFK 283
           S L ++FG+    ++G  S  Y  +     +   N  S+ V L V   L   K     F 
Sbjct: 243 SQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFN 302

Query: 284 EKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDA 343
           +  P   P+E F ++  T I+   ++    +  ++  +P   L P  PD SL   + + A
Sbjct: 303 Q-YPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQA 361

Query: 344 IAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQ 403
            ++++V   + I + K +A+ H Y V+ NQ+LIA+GLCN + S F++   + +++R+++Q
Sbjct: 362 FSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQ 421

Query: 404 EGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWR 463
           + +GG+ Q A  + + ++LL+++  G  F +LP AVL+ I++ N+       S+LP  WR
Sbjct: 422 DKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWR 481

Query: 464 TSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRT 503
             + +  +W+ TF SS+FLGLD GLI +V+ A      R+
Sbjct: 482 QDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRS 521


>gi|85540447 solute carrier family 26, member 11 [Homo sapiens]
          Length = 606

 Score =  182 bits (463), Expect = 5e-46
 Identities = 138/493 (27%), Positives = 236/493 (47%), Gaps = 68/493 (13%)

Query: 49  AFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVP 108
           A  C+P  ++      LPI  WLP+Y   +++  D V+G+S G+  +PQ LA+A +A +P
Sbjct: 22  ACCCSPAALQRR----LPILAWLPSYSL-QWLKMDFVAGLSVGLTAIPQALAYAEVAGLP 76

Query: 109 PIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGT 168
           P +GLYS+F    +Y FLGTSR +++GP A++SL++                        
Sbjct: 77  PQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVSFYTFH------------------ 118

Query: 169 EARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKY 228
                     A+ +  LSG IQ  +GV R GF+  +++ P+++GFT+AAAV +    +K 
Sbjct: 119 ------EPAYAVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKN 172

Query: 229 LFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPA 288
           L G++       F  VY T      +    V    +GL+   LLL  K   +      P 
Sbjct: 173 LLGLQNIP-RPFFLQVYHT---FLRIAETRVGDAVLGLVCMLLLLVLKLMRDHVPPVHPE 228

Query: 289 PIP-------LEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGL-------LPP------ 328
             P       L + A      +   F    +Y+ +V G  P  L       LPP      
Sbjct: 229 MPPGVRLSRGLVWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPVRIPPF 288

Query: 329 ----ANPDTSLFHLVYVDAIAIAIV---GFSVTISMAKTLANKHGYQVDGNQELIALGLC 381
               AN   S   +V      +A+V   G   +I++AK  A+++ Y++D NQEL+A+GL 
Sbjct: 289 SVTTANGTISFTEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLT 348

Query: 382 NSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLS 441
           N +GSL  ++ ++ S  R+ V   +G  T   G +  +++LL +     LF  +P++ L+
Sbjct: 349 NMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALA 408

Query: 442 AIVIVNLKGMFMQFSDLPFF---WRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLT 498
           A++I+ +  +F    D   F   WR  +++L     TF+   F  + YG++   +++LL 
Sbjct: 409 AVIIMAVAPLF----DTKIFRTLWRVKRLDLLPLCVTFL-LCFWEVQYGILAGALVSLLM 463

Query: 499 VIYRTQSFHTEMT 511
           +++      T+++
Sbjct: 464 LLHSAARPETKVS 476


>gi|217272870 solute carrier family 26, member 9 isoform c [Homo
           sapiens]
          Length = 459

 Score =  152 bits (385), Expect = 5e-37
 Identities = 71/162 (43%), Positives = 107/162 (66%)

Query: 343 AIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLV 402
           A ++AIV + + ++M +TLANKHGY VD NQE+IALG  N  GS F+   I C+LS +L 
Sbjct: 5   AFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLA 64

Query: 403 QEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFW 462
            +G GGK+Q+A    SL++++ +L  G     LP++VL A++ VNLK    Q +D  + W
Sbjct: 65  VDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLW 124

Query: 463 RTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQ 504
           R SK++  IW+ +F+SS FL L YG+   V  ++L V+++TQ
Sbjct: 125 RKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQ 166


>gi|20336285 solute carrier family 26, member 8 isoform b [Homo
           sapiens]
          Length = 865

 Score =  136 bits (342), Expect = 5e-32
 Identities = 64/187 (34%), Positives = 114/187 (60%)

Query: 317 VVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELI 376
           ++  +P   L P  PD SL   + + A ++++V   + I + K +A+ H Y V+ NQ+LI
Sbjct: 230 LIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLI 289

Query: 377 ALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLP 436
           A+GLCN + S F++   + +++R+++Q+ +GG+ Q A  + + ++LL+++  G  F +LP
Sbjct: 290 AIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLP 349

Query: 437 QAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIAL 496
            AVL+ I++ N+       S+LP  WR  + +  +W+ TF SS+FLGLD GLI +V+ A 
Sbjct: 350 NAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAF 409

Query: 497 LTVIYRT 503
                R+
Sbjct: 410 FITTVRS 416



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 45/147 (30%), Positives = 79/147 (53%), Gaps = 9/147 (6%)

Query: 52  CTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLA--AVPP 109
           C+  +    +    P  +W+  Y+ K+++LGDL++GIS G++Q+PQGL  ++LA   +PP
Sbjct: 64  CSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPP 123

Query: 110 IFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIGGVAVRLVPDDIVIPGGVNATNGT 168
           +   Y++F   ++Y   G+   +SIG F ++S L+I  + V    +  ++ G     N  
Sbjct: 124 LNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSF-VKNEF 182

Query: 169 EARDAL-----RVKVAMSVTLLSGIIQ 190
            A   L      + V  + T L+GIIQ
Sbjct: 183 SAPSYLMGYNKSLSVVATTTFLTGIIQ 209


>gi|20336274 solute carrier family 26, member 1 isoform b [Homo
           sapiens]
          Length = 224

 Score =  109 bits (273), Expect = 5e-24
 Identities = 56/157 (35%), Positives = 100/157 (63%), Gaps = 13/157 (8%)

Query: 51  TCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPI 110
           +C+   +R ++   LP T+WL  Y+ +EY+ GD++SG+  G++ +PQ +A+++LA + PI
Sbjct: 40  SCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPI 99

Query: 111 FGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLV-------PDDIVIPGGVN 163
           + LY+SF+  ++Y  +GTSRH+S+G F+++ LM+G V  R +         D + PG  +
Sbjct: 100 YSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANS 159

Query: 164 AT-NGTEA-----RDALRVKVAMSVTLLSGIIQFCLG 194
           +T NG+ A     RD   ++VA ++TL++G+ Q   G
Sbjct: 160 STLNGSAAMLDCGRDCYAIRVATALTLMTGLYQTSWG 196


>gi|45827778 reticulon 1 isoform B [Homo sapiens]
          Length = 356

 Score = 29.6 bits (65), Expect = 6.9
 Identities = 14/36 (38%), Positives = 21/36 (58%)

Query: 466 KIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIY 501
           K  + +WL T+V +LF GL   L+  V +  L V+Y
Sbjct: 284 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVY 319


>gi|45827776 reticulon 1 isoform C [Homo sapiens]
          Length = 208

 Score = 29.6 bits (65), Expect = 6.9
 Identities = 14/36 (38%), Positives = 21/36 (58%)

Query: 466 KIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIY 501
           K  + +WL T+V +LF GL   L+  V +  L V+Y
Sbjct: 136 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVY 171


>gi|10863935 reticulon 1 isoform A [Homo sapiens]
          Length = 776

 Score = 29.6 bits (65), Expect = 6.9
 Identities = 14/36 (38%), Positives = 21/36 (58%)

Query: 466 KIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIY 501
           K  + +WL T+V +LF GL   L+  V +  L V+Y
Sbjct: 704 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVY 739


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.141    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,167,515
Number of Sequences: 37866
Number of extensions: 703212
Number of successful extensions: 1857
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1805
Number of HSP's gapped (non-prelim): 28
length of query: 516
length of database: 18,247,518
effective HSP length: 107
effective length of query: 409
effective length of database: 14,195,856
effective search space: 5806105104
effective search space used: 5806105104
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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