Search of human proteins with 132566536

Search of human proteins with 132566536

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|132566536 voltage-gated calcium channel alpha(2)delta-4
subunit [Homo sapiens]
         (1137 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|132566536 voltage-gated calcium channel alpha(2)delta-4 subun...  2307   0.0  
gi|54112397 calcium channel, voltage-dependent, alpha 2/delta 3 ...  1354   0.0  
gi|54112392 calcium channel, voltage-dependent, alpha 2/delta su...   439   e-123
gi|54112394 calcium channel, voltage-dependent, alpha 2/delta su...   435   e-121
gi|54112390 calcium channel, voltage-dependent, alpha 2/delta su...   394   e-109
gi|110578649 cache domain containing 1 [Homo sapiens]                  83   1e-15
gi|70778918 inter-alpha globulin inhibitor H2 polypeptide [Homo ...    59   3e-08
gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein [...    55   5e-07
gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]         52   2e-06
gi|156119625 inter-alpha (globulin) inhibitor H1 [Homo sapiens]        50   9e-06
gi|38348336 inter-alpha (globulin) inhibitor H5-like [Homo sapiens]    45   3e-04
gi|49355778 inter-alpha trypsin inhibitor heavy chain precursor ...    44   9e-04
gi|153945780 inter-alpha trypsin inhibitor heavy chain precursor...    44   9e-04
gi|153945711 inter-alpha trypsin inhibitor heavy chain precursor...    44   9e-04
gi|6005970 zinc finger protein 175 [Homo sapiens]                      38   0.048
gi|56711320 hypothetical protein LOC145407 [Homo sapiens]              33   2.0  
gi|237858799 adenylate kinase domain containing 1 isoform 1 [Hom...    32   2.6  
gi|11321565 matrilin 3 precursor [Homo sapiens]                        32   2.6  
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t...    32   3.4  
gi|44921608 Morf4 family associated protein 1-like 1 [Homo sapiens]    32   4.5  
gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo...    32   4.5  
gi|55769533 PRKC, apoptosis, WT1, regulator [Homo sapiens]             31   5.9  
gi|62632750 ATPase, class VI, type 11B [Homo sapiens]                  31   7.6  
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap...    30   10.0 
gi|148596944 C2 calcium-dependent domain containing 3 [Homo sapi...    30   10.0 

>gi|132566536 voltage-gated calcium channel alpha(2)delta-4 subunit
            [Homo sapiens]
          Length = 1137

 Score = 2307 bits (5979), Expect = 0.0
 Identities = 1137/1137 (100%), Positives = 1137/1137 (100%)

Query: 1    MVCGCSALLPLPNPRPTMPATPNFLANPSSSSRWIPLQPMPVAWAFVQKTSALLWLLLLG 60
            MVCGCSALLPLPNPRPTMPATPNFLANPSSSSRWIPLQPMPVAWAFVQKTSALLWLLLLG
Sbjct: 1    MVCGCSALLPLPNPRPTMPATPNFLANPSSSSRWIPLQPMPVAWAFVQKTSALLWLLLLG 60

Query: 61   TSLSPAWGQAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVDGL 120
            TSLSPAWGQAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVDGL
Sbjct: 61   TSLSPAWGQAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVDGL 120

Query: 121  ELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDEKGNF 180
            ELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDEKGNF
Sbjct: 121  ELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDEKGNF 180

Query: 181  VELGAEFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQR 240
            VELGAEFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQR
Sbjct: 181  VELGAEFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQR 240

Query: 241  DPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNRGWYIQAATSPKDIVILVDVSG 300
            DPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNRGWYIQAATSPKDIVILVDVSG
Sbjct: 241  DPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNRGWYIQAATSPKDIVILVDVSG 300

Query: 301  SMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQADRDNREHFKL 360
            SMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQADRDNREHFKL
Sbjct: 301  SMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQADRDNREHFKL 360

Query: 361  LVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGAVEDYEPVFEKYNW 420
            LVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGAVEDYEPVFEKYNW
Sbjct: 361  LVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGAVEDYEPVFEKYNW 420

Query: 421  PDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVMEYLHVLSRPMVIN 480
            PDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVMEYLHVLSRPMVIN
Sbjct: 421  PDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVMEYLHVLSRPMVIN 480

Query: 481  HDHDIIWTEAYMDSKLLSSQAQSLTLLTTVAMPVFSKKNETRSHGILLGVVGSDVALREL 540
            HDHDIIWTEAYMDSKLLSSQAQSLTLLTTVAMPVFSKKNETRSHGILLGVVGSDVALREL
Sbjct: 481  HDHDIIWTEAYMDSKLLSSQAQSLTLLTTVAMPVFSKKNETRSHGILLGVVGSDVALREL 540

Query: 541  MKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPKPNYNSVDLSEVEWEDQA 600
            MKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPKPNYNSVDLSEVEWEDQA
Sbjct: 541  MKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPKPNYNSVDLSEVEWEDQA 600

Query: 601  ESLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYI 660
            ESLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYI
Sbjct: 601  ESLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYI 660

Query: 661  LLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLSQLEAMIRFLTRKDPDLECDE 720
            LLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLSQLEAMIRFLTRKDPDLECDE
Sbjct: 661  LLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLSQLEAMIRFLTRKDPDLECDE 720

Query: 721  ELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFLGTRAGLLRSSLFVGSEKVSD 780
            ELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFLGTRAGLLRSSLFVGSEKVSD
Sbjct: 721  ELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFLGTRAGLLRSSLFVGSEKVSD 780

Query: 781  RKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRWAEGPESAGEPMVVTASTAVAV 840
            RKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRWAEGPESAGEPMVVTASTAVAV
Sbjct: 781  RKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRWAEGPESAGEPMVVTASTAVAV 840

Query: 841  TVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSDLDCFVIDNNGFIL 900
            TVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSDLDCFVIDNNGFIL
Sbjct: 841  TVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSDLDCFVIDNNGFIL 900

Query: 901  ISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISA 960
            ISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISA
Sbjct: 901  ISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISA 960

Query: 961  FLTATRWLLQELVLFLLEWSVWGSWYDRGAEAKSVFHHSHKHKKQDPLQPCDTEYPVFVY 1020
            FLTATRWLLQELVLFLLEWSVWGSWYDRGAEAKSVFHHSHKHKKQDPLQPCDTEYPVFVY
Sbjct: 961  FLTATRWLLQELVLFLLEWSVWGSWYDRGAEAKSVFHHSHKHKKQDPLQPCDTEYPVFVY 1020

Query: 1021 QPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSIFPPVLQEATEVKYNASV 1080
            QPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSIFPPVLQEATEVKYNASV
Sbjct: 1021 QPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSIFPPVLQEATEVKYNASV 1080

Query: 1081 KCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPPLLLLPVCAWGLLPQLLR 1137
            KCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPPLLLLPVCAWGLLPQLLR
Sbjct: 1081 KCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPPLLLLPVCAWGLLPQLLR 1137


>gi|54112397 calcium channel, voltage-dependent, alpha 2/delta 3
            subunit [Homo sapiens]
          Length = 1091

 Score = 1354 bits (3505), Expect = 0.0
 Identities = 648/1083 (59%), Positives = 842/1083 (77%), Gaps = 20/1083 (1%)

Query: 51   SALLWLLLLGTSLSPAW-GQAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVE 109
            SALL   LL  +L      + +IPL  VKLWA  FGG++ +   KYSGS LLQKKYK+ E
Sbjct: 15   SALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYE 74

Query: 110  SSLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSV 169
              + IEE+DGL+LV+K +++ME M  +K EAV+ LVEAAEEA L HEF+  L ++Y+N+V
Sbjct: 75   KDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAV 134

Query: 170  LINERDEKGNFVELGAEFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEA 229
            LINERD+ GNF+ELG EF+L  N HF+NLPVN S+S VQ+PTN+YNKDP I+NGVY SE+
Sbjct: 135  LINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSES 194

Query: 230  LNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNRGWYIQAATSP 289
            LN VFV+NF RDP+L WQYFGSA GFFR YPGIKW PDENGVI FDCRNR WYIQAATSP
Sbjct: 195  LNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSP 254

Query: 290  KDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQ 349
            KD+VILVDVSGSMKGLR+TIAK T+++ILDTLG++DF NIIAYN+ +HY+EPC  G LVQ
Sbjct: 255  KDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQ 314

Query: 350  ADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGAVE 409
            ADR N+EHF+  +++L  KG+G++D AL EAF IL  F    QGS+C+QAIMLI+DGAV+
Sbjct: 315  ADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVD 374

Query: 410  DYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVMEY 469
             Y+ +F KYNWPD KVR+FTYLIGRE +FAD +KW+AC NKG++TQISTLAD QENVMEY
Sbjct: 375  TYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEY 434

Query: 470  LHVLSRPMVINHDHDIIWTEAYMDSKLLSSQAQSLT------LLTTVAMPVFSKKNETRS 523
            LHVLSRP VI+ +HD++WTEAY+DS L   QAQ LT      L+TTVAMPVFSK+NETRS
Sbjct: 435  LHVLSRPKVIDQEHDVVWTEAYIDSTL--PQAQKLTDDQGPVLMTTVAMPVFSKQNETRS 492

Query: 524  HGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPK 583
             GILLGVVG+DV ++EL+K  P+YKLG+HGYAF  TNNGYIL+HP+LR LY EGKK + K
Sbjct: 493  KGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKK-RRK 551

Query: 584  PNYNSVDLSEVEWEDQAESLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDYFFTDISD 643
            PNY+SVDLSEVEWED+ + LR AM+NR+TG  SM+VK  +DKGKRVL +TNDY++TDI  
Sbjct: 552  PNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKG 611

Query: 644  TPFSLGVVLSRGHGEYILLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLSQLE 703
            TPFSLGV LSRGHG+Y   GN ++EEGLHDL HPD++LA +W YC TD+ P+HR LSQLE
Sbjct: 612  TPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLE 671

Query: 704  AMIRFLTRKDPDLECDEELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFLGTR 763
            A+  +L  K+P L+CD+EL++EVLFDAVV+AP+EAYWT+LALN SE S+  V++AFLGTR
Sbjct: 672  AIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTR 731

Query: 764  AGLLRSSLFVGSEKVSDRKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRWAEGP 823
             GL R +LFVG+E+++++ FL   D+ ++F  D FPLWYR+A+E   GSFV+++ ++ GP
Sbjct: 732  TGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGP 791

Query: 824  ESAGEPMVVTASTAVAVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSC 883
                +  VVTAST++ +  ++++ + AA G+QMKLEF QRKFW A+RQC+++DG C+ SC
Sbjct: 792  --VNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISC 849

Query: 884  EDSDLDCFVIDNNGFILISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKP 943
            +D  ++C++IDNNGFIL+S+   +TG F GE++GAV+ +LL+MG F ++T+YDYQAMC+ 
Sbjct: 850  DDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRA 909

Query: 944  SSHHHSAAQPLVSPISAFLTATRWLLQELVLFLLEWSVWGSWYDRGAEAKSVFHHSHKHK 1003
            +      A  L+ P +AFL+A +W++ ELVLFL+E+++  SW+     AK+        K
Sbjct: 910  NKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLC-SWWHSDMTAKA-------QK 961

Query: 1004 KQDPLQPCDTEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSI 1063
             +  L+PCDTEYP FV +  I+E  G + C  C K FV+QQIP+SNL ++V D +C C  
Sbjct: 962  LKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCES 1021

Query: 1064 FPPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPPLLL 1123
              P+     E++YN S+KC+R+++QK+RRRP+SCH FHPEENA++CGGA    A   LLL
Sbjct: 1022 VAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPEENARECGGAPSLQAQTVLLL 1081

Query: 1124 LPV 1126
            LP+
Sbjct: 1082 LPL 1084


>gi|54112392 calcium channel, voltage-dependent, alpha 2/delta subunit
            2 isoform a [Homo sapiens]
          Length = 1145

 Score =  439 bits (1130), Expect = e-123
 Identities = 337/1123 (30%), Positives = 552/1123 (49%), Gaps = 119/1123 (10%)

Query: 54   LWLLL--LGTSLSPAWGQAKIPLE-TVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVES 110
            LWLLL  L    +P       P + T++ WA     ++   +  + G   L++ YKD  +
Sbjct: 44   LWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRN 103

Query: 111  SLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFD---YYN 167
              +++E +  +LV K + D+E++L RKV+A++ L +AAE     H + +++  +   YY+
Sbjct: 104  LFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYD 163

Query: 168  SVLINERDE-KGNFVELGA-------EFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPD 219
            +    E D+ +   VE G+       +F+ + N  F N  VN S ++VQ+PT++Y     
Sbjct: 164  AKADAELDDPESEDVERGSKASTLRLDFIEDPN--FKN-KVNYSYAAVQIPTDIYKGSTV 220

Query: 220  ILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNR 279
            ILN +  +EAL  VF+EN ++DPTL WQ FGSATG  R YP   W   +  +  +D R R
Sbjct: 221  ILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKK-IDLYDVRRR 279

Query: 280  GWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYI 339
             WYIQ A+SPKD+VI+VDVSGS+ GL + + K ++  +LDTL ++D++N+ ++N+    +
Sbjct: 280  PWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPV 339

Query: 340  EPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQA 399
              CF   LVQA+  N++ FK  V+ ++ KG          AF  L+     +    CN+ 
Sbjct: 340  S-CFTH-LVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRAN--CNKM 395

Query: 400  IMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTL 459
            IM+ +DG  +  + VFEKYNWP+  VRVFT+ +G+       ++W+AC NKGYY +I ++
Sbjct: 396  IMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSI 455

Query: 460  ADTQENVMEYLHVLSRPMVI--NHDHDIIWTEAYMDSKLLSSQAQSLTLLTTVAMPVFSK 517
               + N  EYL VL RPMV+       + WT  Y D       A  L L+ T  +PVF+ 
Sbjct: 456  GAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYED-------ALGLGLVVTGTLPVFNL 508

Query: 518  KNE---TRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPL- 573
              +    + + ++LGV+G DVAL ++ +L P Y LG +GY F    NGY+L HP+L+P  
Sbjct: 509  TQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQT 568

Query: 574  --YREGKKLKPKPNYNSVDLSEVEWEDQ-AESLRTAMINRETGTLSMDVKVPMDKGKRVL 630
              +RE   L         D  + E ED+  E +R +MI+   G   +   V     + + 
Sbjct: 569  TNFREPVTL---------DFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYID 619

Query: 631  FLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTS---VEEGLHDLLHPDLALAGDWI- 686
             +T +Y +  I  T +SLG+VL   +  + L  N S   ++    + L P    +   + 
Sbjct: 620  EVTRNYTWVPIRSTNYSLGLVLP-PYSTFYLQANLSDQILQVKYFEFLLPSSFESEGHVF 678

Query: 687  -----YCITDIDPDHRKLSQLEAMIRFLTRKDPD-LECDEELVREVLFDAVVTAPM-EAY 739
                 YC  D++        L+  I  + +  PD  +C+  L+  ++ D  +T  + E  
Sbjct: 679  IAPREYC-KDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERV 737

Query: 740  WTALALNMSEESEHVVDMAFLGTRAGLLRSSLFVGSEKVSDRKFLTPEDEASVFTLDRFP 799
            W    LN      + +   F  T  G+ R    V   K ++     PE   + F      
Sbjct: 738  WRDQDLN-----TYSLLAVFAATDGGITR----VFPNKAAEDWTENPEPFNASF------ 782

Query: 800  LWYRQASEHPAGSFVFNLRWAEG----PESAGEPMVVTASTAVAVTVDKRTAIAAAAGVQ 855
              YR++ ++    +VF     +      E   + + +  STAV +++ +RT   A  GV+
Sbjct: 783  --YRRSLDN--HGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVK 838

Query: 856  MKLEFLQRKFWAATRQCSTVDGP--------CTQSCE--DSDLDCFVIDNNGFILISKRS 905
            + LE    KF       +  D P        C   CE  + DL C +ID+ GF+++S ++
Sbjct: 839  LDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQN 898

Query: 906  R---ETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQP---LVSPIS 959
                + GRF  EVD  ++  L +   +++   YDYQA C P    +  A P    V  ++
Sbjct: 899  HQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVA 958

Query: 960  AFL------TATRWLLQELVLFLLEWSVWGSWYDRG-AEAKSVFHHSHKHKKQDPLQPCD 1012
             FL      +A  W L + +L+ L   ++ SW+    AEA+           +     C 
Sbjct: 959  DFLNLAWWTSAAAWSLFQQLLYGL---IYHSWFQADPAEAEG--------SPETRESSCV 1007

Query: 1013 TEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTD-PTCDCSIFPPVLQEA 1071
             +   + +       N I++CG C ++F  Q++ N+NLL +V + P C       +LQ+ 
Sbjct: 1008 MKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKE 1067

Query: 1072 TEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCG-GAS 1113
            T    +   +C+ ++  + RR P  C  ++  E+  DCG GAS
Sbjct: 1068 THCPADGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGAS 1110


>gi|54112394 calcium channel, voltage-dependent, alpha 2/delta subunit
            2 isoform b [Homo sapiens]
          Length = 1143

 Score =  435 bits (1119), Expect = e-121
 Identities = 337/1123 (30%), Positives = 552/1123 (49%), Gaps = 121/1123 (10%)

Query: 54   LWLLL--LGTSLSPAWGQAKIPLE-TVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVES 110
            LWLLL  L    +P       P + T++ WA     ++   +  + G   L++ YKD  +
Sbjct: 44   LWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRN 103

Query: 111  SLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFD---YYN 167
              +++E +  +LV K + D+E++L RKV+A++ L +AAE     H + +++  +   YY+
Sbjct: 104  LFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYD 163

Query: 168  SVLINERDE-KGNFVELGA-------EFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPD 219
            +    E D+ +   VE G+       +F+ + N  F N  VN S ++VQ+PT++Y     
Sbjct: 164  AKADAELDDPESEDVERGSKASTLRLDFIEDPN--FKN-KVNYSYAAVQIPTDIYKGSTV 220

Query: 220  ILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNR 279
            ILN +  +EAL  VF+EN ++DPTL WQ FGSATG  R YP   W   +  +  +D R R
Sbjct: 221  ILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKK-IDLYDVRRR 279

Query: 280  GWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYI 339
             WYIQ A+SPKD+VI+VDVSGS+ GL + + K ++  +LDTL ++D++N+ ++N+    +
Sbjct: 280  PWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPV 339

Query: 340  EPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQA 399
              CF   LVQA+  N++ FK  V+ ++ KG          AF  L+     +    CN+ 
Sbjct: 340  S-CFTH-LVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRAN--CNKM 395

Query: 400  IMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTL 459
            IM+ +DG  +  + VFEKYNWP+  VRVFT+ +G+       ++W+AC NKGYY +I ++
Sbjct: 396  IMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSI 455

Query: 460  ADTQENVMEYLHVLSRPMVI--NHDHDIIWTEAYMDSKLLSSQAQSLTLLTTVAMPVFSK 517
               + N  EYL VL RPMV+       + WT  Y D       A  L L+ T  +PVF+ 
Sbjct: 456  GAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYED-------ALGLGLVVTGTLPVFNL 508

Query: 518  KNE---TRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPL- 573
              +    + + ++LGV+G DVAL ++ +L P Y LG +GY F    NGY+L HP+L+P  
Sbjct: 509  TQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQT 568

Query: 574  --YREGKKLKPKPNYNSVDLSEVEWEDQ-AESLRTAMINRETGTLSMDVKVPMDKGKRVL 630
              +RE   L         D  + E ED+  E +R +MI+   G   +   V     + + 
Sbjct: 569  TNFREPVTL---------DFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYID 619

Query: 631  FLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTS---VEEGLHDLLHPDLALAGDWI- 686
             +T +Y +  I  T +SLG+VL   +  + L  N S   ++    + L P    +   + 
Sbjct: 620  EVTRNYTWVPIRSTNYSLGLVLP-PYSTFYLQANLSDQILQVKYFEFLLPSSFESEGHVF 678

Query: 687  -----YCITDIDPDHRKLSQLEAMIRFLTRKDPD-LECDEELVREVLFDAVVTAPM-EAY 739
                 YC  D++        L+  I  + +  PD  +C+  L+  ++ D  +T  + E  
Sbjct: 679  IAPREYC-KDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERV 737

Query: 740  WTALALNMSEESEHVVDMAFLGTRAGLLRSSLFVGSEKVSDRKFLTPEDEASVFTLDRFP 799
            W    LN      + +   F  T  G+ R    V   K ++     PE   + F      
Sbjct: 738  WRDQDLN-----TYSLLAVFAATDGGITR----VFPNKAAEDWTENPEPFNASF------ 782

Query: 800  LWYRQASEHPAGSFVFNLRWAEG----PESAGEPMVVTASTAVAVTVDKRTAIAAAAGVQ 855
              YR++ ++    +VF     +      E   + + +  STAV +++ +RT   A  GV+
Sbjct: 783  --YRRSLDN--HGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVK 838

Query: 856  MKLEFLQRKFWAATRQCSTVDGP--------CTQSCE--DSDLDCFVIDNNGFILISKRS 905
            + LE    KF       +  D P        C   CE  + DL C +ID+ GF+++S ++
Sbjct: 839  LDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQN 898

Query: 906  R---ETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQP---LVSPIS 959
                + GRF  EVD  ++  L +   +++   YDYQA C P    +  A P    V  ++
Sbjct: 899  HQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVA 958

Query: 960  AFL------TATRWLLQELVLFLLEWSVWGSWYDRG-AEAKSVFHHSHKHKKQDPLQPCD 1012
             FL      +A  W L + +L+ L   ++ SW+    AEA+           +     C 
Sbjct: 959  DFLNLAWWTSAAAWSLFQQLLYGL---IYHSWFQADPAEAEG--------SPETRESSCV 1007

Query: 1013 TEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTD-PTCDCSIFPPVLQEA 1071
             +   + +       N I++CG C ++F  Q++ N+NLL +V + P C       +LQ+ 
Sbjct: 1008 MKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQK- 1066

Query: 1072 TEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCG-GAS 1113
             E   +   +C+ ++  + RR P  C  ++  E+  DCG GAS
Sbjct: 1067 -ETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGAS 1108


>gi|54112390 calcium channel, voltage-dependent, alpha 2/delta subunit
            1 [Homo sapiens]
          Length = 1091

 Score =  394 bits (1012), Expect = e-109
 Identities = 320/1128 (28%), Positives = 535/1128 (47%), Gaps = 128/1128 (11%)

Query: 50   TSALLWLLLLGTSLSPAWGQAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVE 109
            T  L   LL+G S    +  A     T+K W D    DL       SG   L   Y+  +
Sbjct: 10   TLTLFQSLLIGPSSEEPFPSAV----TIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQ 65

Query: 110  SSLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFD---YY 166
                +E  +  +LV   + D+E +L  + +A+  L   AE+    H++ E    +   YY
Sbjct: 66   DLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYY 125

Query: 167  NSVLINERDEKGNFVELGAEFLLE---SNAHFSNLPVNTSISSVQLPTNVYNKDPDILNG 223
            N+   ++ D + N  E G++ +      +A+F    ++   ++V +PT++Y     +LN 
Sbjct: 126  NAK--DDLDPEKNDSEPGSQRIKPVFIEDANFGR-QISYQHAAVHIPTDIYEGSTIVLNE 182

Query: 224  VYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDE---NGVITFDCRNRG 280
            +  + AL+ VF +N + DP+L WQ FGSATG  R YP   W  +    N +  +D R R 
Sbjct: 183  LNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRP 242

Query: 281  WYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIE 340
            WYIQ A SPKD++ILVDVSGS+ GL + + + +++ +L+TL ++DF+N+ ++N     + 
Sbjct: 243  WYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVS 302

Query: 341  PCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAI 400
             CF+  LVQA+  N++  K  V  +  KG+    +    AF+ L  +  ++    CN+ I
Sbjct: 303  -CFQH-LVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRAN--CNKII 358

Query: 401  MLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLA 460
            ML +DG  E  + +F KYN  D KVRVFT+ +G+       ++W+AC NKGYY +I ++ 
Sbjct: 359  MLFTDGGEERAQEIFNKYN-KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIG 417

Query: 461  DTQENVMEYLHVLSRPMVINHD--HDIIWTEAYMDSKLLSSQAQSLTLLTTVAMPVFS-- 516
              + N  EYL VL RPMV+  D    + WT  Y+D       A  L L+ T  +PVF+  
Sbjct: 418  AIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLD-------ALELGLVITGTLPVFNIT 470

Query: 517  --KKNETR-SHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPL 573
               +N+T   + ++LGV+G DV+L ++ +L PR+ L  +GY F    NGY+L HP+L+P 
Sbjct: 471  GQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQP- 529

Query: 574  YREGKKLKPKPNYNSVDLSEVEWEDQAE-SLRTAMINRETGTLSMDVKVP------MDKG 626
             +  K  +P     ++D  + E E+  +  +R  MI+ E+G  +    V       +DKG
Sbjct: 530  -KNPKSQEPV----TLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKG 584

Query: 627  KRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTSVEEGL------------HDL 674
             R       Y +T ++ T +SL +VL      YI      +EE +             + 
Sbjct: 585  NRT------YTWTPVNGTDYSLALVLPTYSFYYI---KAKLEETITQARSKKGKMKDSET 635

Query: 675  LHPD------LALAGDWIYCITDIDPDHRKLSQLEAMIRFLTRKDP-DLECDEELVREVL 727
            L PD              YC  D+         L     F+ RK P +  C+ +L+  VL
Sbjct: 636  LKPDNFEESGYTFIAPRDYC-NDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVL 694

Query: 728  FDAVVTAPM-EAYWTALALNMSEESEHVVDMAFLGTRAGLLRSSLFVGSEKVSDRKFLTP 786
             DA  T  + + YW+       +++   V   F+ T  G+ R    V  ++  +     P
Sbjct: 695  LDAGFTNELVQNYWS------KQKNIKGVKARFVVTDGGITR----VYPKEAGENWQENP 744

Query: 787  EDEASVFTLDRFPLWYRQASEHPAGSFVFNLRWAEGPESAGEPMVVTASTAVAVTVDKRT 846
            E     F        Y+++ ++   ++VF   +            +  S AV + +  + 
Sbjct: 745  ETYEDSF--------YKRSLDN--DNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKL 794

Query: 847  AIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSD-LDCFVIDNNGFILISKR- 904
               A  G+++ +      F   T       GP      +SD +DC ++D+ GF+L++   
Sbjct: 795  LKPAVVGIKIDVNSWIENF-TKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHD 853

Query: 905  --SRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKP------SSHHHSAAQPLVS 956
              + + GRF GE+D +++  L+++ V++    YDYQ++C+P       + H SA  P V+
Sbjct: 854  DYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVA 913

Query: 957  ---PISAFLTATRW-LLQELVLFLLEWSVWGSWYDRGAEAKSVFHHSHKHKKQDPLQPCD 1012
                I  + TA  W +LQ+ +L L         + R  EA  V             Q C 
Sbjct: 914  DILQIGWWATAAAWSILQQFLLSLT--------FPRLLEA--VEMEDDDFTASLSKQSCI 963

Query: 1013 TEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDP--TCDCSIFPPVLQE 1070
            TE   + +    +  +G+++CG C ++F  +++ N+NL+ ++ +   TC C     +  E
Sbjct: 964  TEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAE 1023

Query: 1071 ATEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSAS 1118
             T    N    CD ++  + R+ PD C   +  E+  DCGG S  + S
Sbjct: 1024 QTSDGPN---PCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS 1068


>gi|110578649 cache domain containing 1 [Homo sapiens]
          Length = 1223

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 116/503 (23%), Positives = 212/503 (42%), Gaps = 69/503 (13%)

Query: 188 LLESNAHFSNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQ 247
           ++E + +F N  V+ +IS  +L T V ++             LN+V  +N + +P + WQ
Sbjct: 84  MMEFDGNF-NTNVSRTISCDRLSTTVNSR------AFNPGRDLNSVLADNLKSNPGIKWQ 136

Query: 248 YFGSATGFFRIYPGIKWTPDENGVITFDCRNRGWYIQAA-TSPKDIVILVDVSGSMKGLR 306
           YF S  G F ++P  K+        +++ R+R  Y+       K IV+++D   S+   +
Sbjct: 137 YFSSEEGIFTVFPAHKFRCKG----SYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQ 192

Query: 307 MTIAKHTITTILDTLGENDFINIIAYNDYVH--YIEPCFKGILVQADRDNREHFKLLVEE 364
           + IAK     IL  + E+D I+++   D V    ++ C+K  L  A  + +      V  
Sbjct: 193 LQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFLSPATSETKRKMSTFVSS 252

Query: 365 LMVKGVGVVDQ---ALREAFQILKQF-QEAKQGSLCNQAIMLIS------DGAVED---- 410
             VK      Q     ++AFQ+++      K  +  +  I+ +S      D + ED    
Sbjct: 253 --VKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKAT 310

Query: 411 YEPVFEKYNWPDCKVRVFTYLIG-------REVSFADRMKWIACNNKGYYTQISTLA-DT 462
            + + E+ ++ +  V + TY +        +E++F   ++ +A  N G Y     +A   
Sbjct: 311 LQVINEENSFLNNSVMILTYALMNDGVTGLKELAF---LRDLAEQNSGKYGVPDRMALPV 367

Query: 463 QENVMEYLHVLSRPMVINHDHDIIWTEAYMDSKLLS---SQAQSLTLLTTVAMPVFSKKN 519
            +  M  L+ LS                 +D  + S   S      L+ TV+ P +    
Sbjct: 368 IKGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCY---- 423

Query: 520 ETRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKK 579
                 +LLG+VG DV L  +++    Y+  +  Y FL  + GY L HP L   Y     
Sbjct: 424 ---FGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPY----- 475

Query: 580 LKPKPNYNSVDLSEVEWEDQAESLRTAMINRETG----------TLSMDVKVPMDKGKRV 629
           L  +P  ++ D+   E   + E +R  +++   G          +LS  +    + GK  
Sbjct: 476 LLSEPPLHT-DIIHYENIPKFELVRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEA 534

Query: 630 LFLTNDYFFTDISDTPFSLGVVL 652
             ++  Y +  + DT F L +V+
Sbjct: 535 YNVS--YAWKMVQDTSFILCIVV 555



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 29/121 (23%), Positives = 49/121 (40%), Gaps = 12/121 (9%)

Query: 247 QYFGSATGFFRIYPGIKWTPDENGVITFDCRNRGWYIQAATSPKDIVI---LVDVSGSMK 303
           +Y  +  G  RIYPG            FD   R WY+ A  +P  I +    +DV G+  
Sbjct: 680 RYIATPNGVLRIYPGSLMDK------AFDPTRRQWYLHAVANPGLISLTGPYLDVGGA-- 731

Query: 304 GLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQADRDNREHFKLLVE 363
           G  +TI+ HTI +    L     + ++  +  + Y       +L   ++D     +  + 
Sbjct: 732 GYVVTIS-HTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIM 790

Query: 364 E 364
           E
Sbjct: 791 E 791


>gi|70778918 inter-alpha globulin inhibitor H2 polypeptide [Homo
           sapiens]
          Length = 946

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 54/202 (26%), Positives = 95/202 (47%), Gaps = 19/202 (9%)

Query: 289 PKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILV 348
           PK+I+ ++DVSGSM G++M      + TILD L   D  ++I +N  +      ++  L+
Sbjct: 308 PKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIR----TWRNDLI 363

Query: 349 QADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCN----QAIMLIS 404
            A +      K  +E++   G   +++AL  A  IL    EA    L +      I+L+S
Sbjct: 364 SATKTQVADAKRYIEKIQPSGGTNINEALLRAIFIL---NEANNLGLLDPNSVSLIILVS 420

Query: 405 DGAVEDYEPVFEKY------NWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQIST 458
           DG     E    K       N  D  + +F+  +G +V + D +K ++  N G   +I  
Sbjct: 421 DGDPTVGELKLSKIQKNVKENIQD-NISLFSLGMGFDVDY-DFLKRLSNENHGIAQRIYG 478

Query: 459 LADTQENVMEYLHVLSRPMVIN 480
             DT   + ++ + +S P++ N
Sbjct: 479 NQDTSSQLKKFYNQVSTPLLRN 500


>gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein
           [Homo sapiens]
          Length = 890

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 44/196 (22%), Positives = 92/196 (46%), Gaps = 11/196 (5%)

Query: 289 PKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILV 348
           PK++  ++D+SGSM G ++   K  +  IL+ + E D++N I ++  V      +K  LV
Sbjct: 282 PKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDV----STWKEHLV 337

Query: 349 QADRDNREHFKLLVEELMVKGV-GVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGA 407
           QA  +N +  +  V+ +  KG+  + D  LR    + K  +E +        +++++DG 
Sbjct: 338 QATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGD 397

Query: 408 VEDYEPVFEKY-----NWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADT 462
               E   EK      N    K  ++    G  +++ + ++ +A  N G+  +I   +D 
Sbjct: 398 ANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNY-NFLENMALENHGFARRIYEDSDA 456

Query: 463 QENVMEYLHVLSRPMV 478
              +  +   ++ P++
Sbjct: 457 DLQLQGFYEEVANPLL 472


>gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]
          Length = 930

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 49/200 (24%), Positives = 92/200 (46%), Gaps = 15/200 (7%)

Query: 287 TSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGI 346
           T PK++V ++D SGSM G ++   +  +  ILD L   D  N+I ++       P     
Sbjct: 270 TMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPS---- 325

Query: 347 LVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQIL---KQFQEAKQGSLCNQAIMLI 403
           LV A  +N    +     +   G   ++ A+  A Q+L    Q +   +GS+    I+L+
Sbjct: 326 LVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSV--SLIILL 383

Query: 404 SDG--AVEDYEPVFEKYNWPDC---KVRVFTYLIGREVSFADRMKWIACNNKGYYTQIST 458
           +DG   V +  P   + N  +    +  +F    G +VS+A   K +A +N G   +I  
Sbjct: 384 TDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEK-LALDNGGLARRIHE 442

Query: 459 LADTQENVMEYLHVLSRPMV 478
            +D+   + ++   ++ P++
Sbjct: 443 DSDSALQLQDFYQEVANPLL 462


>gi|156119625 inter-alpha (globulin) inhibitor H1 [Homo sapiens]
          Length = 911

 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 43/200 (21%), Positives = 91/200 (45%), Gaps = 13/200 (6%)

Query: 290 KDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQ 349
           K++V ++D+SGSM+G ++   K  +  IL  +   D+ +++ +   V      +KG LVQ
Sbjct: 291 KNVVFVIDISGSMRGQKVKQTKEALLKILGDMQPGDYFDLVLFGTRVQ----SWKGSLVQ 346

Query: 350 ADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLI------ 403
           A   N +  +  V    +     ++  L    +IL Q QE+    L N A +LI      
Sbjct: 347 ASEANLQAAQDFVRGFSLDEATNLNGGLLRGIEILNQVQESLP-ELSNHASILIMLTDGD 405

Query: 404 -SDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADT 462
            ++G  +  + +    N    +  ++    G  V F + ++ ++  N G   +I    D 
Sbjct: 406 PTEGVTDRSQILKNVRNAIRGRFPLYNLGFGHNVDF-NFLEVMSMENNGRAQRIYEDHDA 464

Query: 463 QENVMEYLHVLSRPMVINHD 482
            + +  +   +++P++++ D
Sbjct: 465 TQQLQGFYSQVAKPLLVDVD 484


>gi|38348336 inter-alpha (globulin) inhibitor H5-like [Homo sapiens]
          Length = 1313

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 6/120 (5%)

Query: 290 KDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQ 349
           K++V ++DVS SM G +M   K  +  IL  L  ND+ NII+++D V+  +    G  +Q
Sbjct: 282 KNVVFVIDVSSSMFGTKMEQTKTAMNVILSDLQANDYFNIISFSDTVNVWK---AGGSIQ 338

Query: 350 ADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQF-QEAKQGSLCNQ--AIMLISDG 406
           A   N    K  +  +   G   V+ AL  A  +L    QE  +G    +   I+ ++DG
Sbjct: 339 ATIQNVHSAKDYLHCMEADGWTDVNSALLAAASVLNHSNQEPGRGPSVGRIPLIIFLTDG 398


>gi|49355778 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 3 [Homo sapiens]
          Length = 702

 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 42/196 (21%), Positives = 89/196 (45%), Gaps = 11/196 (5%)

Query: 289 PKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILV 348
           PK++V ++D S SM G ++   K  + TIL  L   D  +II +++ +      +K  L+
Sbjct: 293 PKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRI----KVWKDHLI 348

Query: 349 QADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQF-QEAKQGSLCNQAIMLISDG- 406
               D+    K+ +  +   G   ++ AL+ A ++L ++   +  G      I+ ++DG 
Sbjct: 349 SVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGK 408

Query: 407 -AVEDYEPVFEKYNWPDC---KVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADT 462
             V +   +    N  +    +V +FT  IG +V F   ++ ++  N G   ++    D 
Sbjct: 409 PTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFR-LLEKLSLENCGLTRRVHEEEDA 467

Query: 463 QENVMEYLHVLSRPMV 478
              ++ +   +  P++
Sbjct: 468 GSQLIGFYDEIRTPLL 483


>gi|153945780 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 1 [Homo sapiens]
          Length = 956

 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 42/196 (21%), Positives = 89/196 (45%), Gaps = 11/196 (5%)

Query: 289 PKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILV 348
           PK++V ++D S SM G ++   K  + TIL  L   D  +II +++ +      +K  L+
Sbjct: 293 PKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRI----KVWKDHLI 348

Query: 349 QADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQF-QEAKQGSLCNQAIMLISDG- 406
               D+    K+ +  +   G   ++ AL+ A ++L ++   +  G      I+ ++DG 
Sbjct: 349 SVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGK 408

Query: 407 -AVEDYEPVFEKYNWPDC---KVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADT 462
             V +   +    N  +    +V +FT  IG +V F   ++ ++  N G   ++    D 
Sbjct: 409 PTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFR-LLEKLSLENCGLTRRVHEEEDA 467

Query: 463 QENVMEYLHVLSRPMV 478
              ++ +   +  P++
Sbjct: 468 GSQLIGFYDEIRTPLL 483


>gi|153945711 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 2 [Homo sapiens]
          Length = 742

 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 42/196 (21%), Positives = 89/196 (45%), Gaps = 11/196 (5%)

Query: 289 PKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILV 348
           PK++V ++D S SM G ++   K  + TIL  L   D  +II +++ +      +K  L+
Sbjct: 79  PKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRI----KVWKDHLI 134

Query: 349 QADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQF-QEAKQGSLCNQAIMLISDG- 406
               D+    K+ +  +   G   ++ AL+ A ++L ++   +  G      I+ ++DG 
Sbjct: 135 SVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGK 194

Query: 407 -AVEDYEPVFEKYNWPDC---KVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADT 462
             V +   +    N  +    +V +FT  IG +V F   ++ ++  N G   ++    D 
Sbjct: 195 PTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFR-LLEKLSLENCGLTRRVHEEEDA 253

Query: 463 QENVMEYLHVLSRPMV 478
              ++ +   +  P++
Sbjct: 254 GSQLIGFYDEIRTPLL 269


>gi|6005970 zinc finger protein 175 [Homo sapiens]
          Length = 711

 Score = 38.1 bits (87), Expect = 0.048
 Identities = 33/119 (27%), Positives = 45/119 (37%), Gaps = 20/119 (16%)

Query: 997  HHSHKHKKQDPLQPCD---TEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLL 1053
            H  H  KK D    C    T+      Q  I     + ECG C K F    +P   L + 
Sbjct: 270  HQIHTQKKPDGCSECGGSFTQKSHLFAQQRIHSVGNLHECGKCGKAF----MPQLKLSVY 325

Query: 1054 VTDPTCDCSIFPPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCGGA 1112
            +TD T D    P + +E  +V    S      ++   R++P  CH         DCG A
Sbjct: 326  LTDHTGD---IPCICKECGKVFIQRSELLTHQKTH-TRKKPYKCH---------DCGKA 371


>gi|56711320 hypothetical protein LOC145407 [Homo sapiens]
          Length = 774

 Score = 32.7 bits (73), Expect = 2.0
 Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 8/71 (11%)

Query: 201 NTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYP 260
           N+S++S Q P  V ++DP +++ V  + +LN  F  N +  P       G A       P
Sbjct: 57  NSSVTSKQTPQLVVSEDPMMMSAVPSATSLNKAFSINKETQP-------GQAGLMQTERP 109

Query: 261 GIKWTPDENGV 271
           G+  TP E+GV
Sbjct: 110 GVS-TPTESGV 119


>gi|237858799 adenylate kinase domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1911

 Score = 32.3 bits (72), Expect = 2.6
 Identities = 34/145 (23%), Positives = 62/145 (42%), Gaps = 8/145 (5%)

Query: 41   PVAWAFVQKTSALLWLLLLGTSLSPAWGQAKIPLETVKLWADTFGGDLYNTVTKYSGSLL 100
            P A  F+Q     ++  LL   +     + K  LE  KL  D       +T+ K    L+
Sbjct: 1143 PDAAVFIQVDDQDIFDRLLPAQIEKWKLKQKKKLERKKLIKDMKAKIRVDTIAKRRAELI 1202

Query: 101  LQKKYKDVESSLKIEEVDGLELVRKFSEDMENMLR----RKVEAVQNLVEAAEEAD---- 152
            L++  K  E+ ++ +E    E + + ++D+EN+L     +  E +    +  +E D    
Sbjct: 1203 LERDKKRRENVVRDDEEISEEELEEDNDDIENILEDEFPKDEEEMSGEEDEEQETDAIER 1262

Query: 153  LNHEFNESLVFDYYNSVLINERDEK 177
            L  E  E    D +N  +I +  E+
Sbjct: 1263 LRGELGEKFEADTHNLQIIQDELER 1287


>gi|11321565 matrilin 3 precursor [Homo sapiens]
          Length = 486

 Score = 32.3 bits (72), Expect = 2.6
 Identities = 31/127 (24%), Positives = 58/127 (45%), Gaps = 11/127 (8%)

Query: 289 PKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILV 348
           P D+V ++D S S++ L  T  K  ++ I+DTL        +A  +Y   ++  F+   +
Sbjct: 81  PLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQ---L 137

Query: 349 QADRDNREHFKLLVEELMVKGVG-----VVDQALREAFQILKQFQEAKQGSLCNQAIMLI 403
           QA  D ++  K  V  +     G      +  A+ EAF +    +E    S   +  +++
Sbjct: 138 QAYTD-KQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGARE--PSSNIPKVAIIV 194

Query: 404 SDGAVED 410
           +DG  +D
Sbjct: 195 TDGRPQD 201


>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
            transporters), member 2 [Homo sapiens]
          Length = 1212

 Score = 32.0 bits (71), Expect = 3.4
 Identities = 27/73 (36%), Positives = 34/73 (46%), Gaps = 9/73 (12%)

Query: 370  VGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGAVEDYEPVF--EKYNWPDCKVRV 427
            + V DQ L EA     QFQ+ KQG        L  DG +    P     K  W DCK+RV
Sbjct: 1001 LNVADQKLLEAST---QFQK-KQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRV 1056

Query: 428  FTYLIGREVSFAD 440
            F   IG +++  D
Sbjct: 1057 F---IGGKINRID 1066


>gi|44921608 Morf4 family associated protein 1-like 1 [Homo sapiens]
          Length = 127

 Score = 31.6 bits (70), Expect = 4.5
 Identities = 22/62 (35%), Positives = 34/62 (54%), Gaps = 4/62 (6%)

Query: 129 DMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDEKGNFVELGAEFL 188
           +M+NML +    ++  VEA+EE+ LNH  + S   D   S L  + +EK   +   AE L
Sbjct: 59  EMDNMLIQ----IKTQVEASEESALNHVQHPSGEADERVSELCEKAEEKAKEIAKMAEML 114

Query: 189 LE 190
           +E
Sbjct: 115 VE 116


>gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo
           sapiens]
          Length = 1724

 Score = 31.6 bits (70), Expect = 4.5
 Identities = 15/45 (33%), Positives = 24/45 (53%)

Query: 288 SPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAY 332
           S  +++I +D S SM+G+    AK      L  +GE   +NII +
Sbjct: 873 SESEVIICLDCSSSMEGVTFLQAKQIALHALSLVGEKQKVNIIQF 917


>gi|55769533 PRKC, apoptosis, WT1, regulator [Homo sapiens]
          Length = 340

 Score = 31.2 bits (69), Expect = 5.9
 Identities = 23/79 (29%), Positives = 38/79 (48%), Gaps = 5/79 (6%)

Query: 82  DTFGGDLYNTVTKYSGSLL----LQKKYKDVESSLKIEEVDGLELVRKFSEDMENMLRRK 137
           D  G   YN     SG+L+    L+KK +D+E  +  E  + L LVR   +D E M+ + 
Sbjct: 245 DRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVR-LMQDKEEMIGKL 303

Query: 138 VEAVQNLVEAAEEADLNHE 156
            E +  L    ++ +  +E
Sbjct: 304 KEEIDLLNRDLDDIEDENE 322


>gi|62632750 ATPase, class VI, type 11B [Homo sapiens]
          Length = 1177

 Score = 30.8 bits (68), Expect = 7.6
 Identities = 38/151 (25%), Positives = 66/151 (43%), Gaps = 28/151 (18%)

Query: 658 EYILLGNTSVEEGLHDLLHPD---LALAGDWIYCITDIDPD------------HRKLSQL 702
           + ILLG T+VE+ L D +      L +AG  ++ +T    +            HR ++ L
Sbjct: 671 DLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNIL 730

Query: 703 EAMIRFLTRKDPDLECDE---ELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDM-- 757
           E     L  +  D EC E   +L R +  D V+   +    T+L+L + E  +  +++  
Sbjct: 731 E-----LINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCR 785

Query: 758 ---AFLGTRAGLLRSSLFVGSEKVSDRKFLT 785
              A L  R   L+ +  +   K+S  K +T
Sbjct: 786 NCSAVLCCRMAPLQKAKVIRLIKISPEKPIT 816


>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
           sapiens]
          Length = 502

 Score = 30.4 bits (67), Expect = 10.0
 Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 25/103 (24%)

Query: 9   LPLPNPRPTM----PATPNFLANPSSSSRW----------IPLQPMPVAWAFVQKTSALL 54
           +P P+ R  +     A P  +++P    RW          + L P  + W  +   S  +
Sbjct: 276 IPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAI 335

Query: 55  W----LLLLGTSLSPAWGQAKIPLETVKLWADTFGGDLYNTVT 93
           +    + L G SL PA       LE   LWA  FG   ++ VT
Sbjct: 336 FGSKTIHLTGRSLLPA-------LEAEPLWATVFGSQSHHEVT 371


>gi|148596944 C2 calcium-dependent domain containing 3 [Homo
           sapiens]
          Length = 1963

 Score = 30.4 bits (67), Expect = 10.0
 Identities = 43/153 (28%), Positives = 68/153 (44%), Gaps = 20/153 (13%)

Query: 660 ILLGNTSVEEG-LHDLLH--PDLALAGDWIYCITDIDPDHRKLSQLEAMIRFLTRKDPDL 716
           +LLG+  + +G   D L   PD    G  +YCI++++      S LE +  F T    D 
Sbjct: 402 LLLGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENL--FYTAPKSDT 459

Query: 717 ECDEELVREVLFDAVVTAPMEAYWTALALN--MSEESEHVVDMAFLGTRAGLLRSSLFVG 774
              + L  E   D +V +   +  TALA +  + E S+H      L  R+   R+   V 
Sbjct: 460 SISDFLSEE---DDIVPSKKISQSTALARSSKVLESSDHK-----LKKRSAGKRNRNLVE 511

Query: 775 SEKVSDRKFLTPED-EASVFTLDRFPLWYRQAS 806
            + +S+    TPED +    ++DR  L  R  S
Sbjct: 512 QQMLSE----TPEDAQTMTLSVDRLALLGRTHS 540


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,549,992
Number of Sequences: 37866
Number of extensions: 1908788
Number of successful extensions: 5233
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 5167
Number of HSP's gapped (non-prelim): 33
length of query: 1137
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1024
effective length of database: 13,968,660
effective search space: 14303907840
effective search space used: 14303907840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.