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Search of human proteins with 4557303
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
(485 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 971 0.0
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 962 0.0
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 639 0.0
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 639 0.0
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 639 0.0
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 508 e-144
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 508 e-144
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 470 e-132
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 410 e-114
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 410 e-114
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 150 3e-36
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 148 9e-36
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 142 9e-34
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 139 6e-33
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 139 8e-33
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 133 4e-31
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 133 4e-31
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 131 2e-30
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 127 3e-29
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 125 1e-28
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 123 4e-28
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 122 6e-28
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 118 1e-26
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 117 2e-26
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 94 4e-19
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 91 2e-18
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 64 4e-10
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 64 4e-10
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 64 4e-10
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 38 0.018
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 971 bits (2511), Expect = 0.0
Identities = 485/485 (100%), Positives = 485/485 (100%)
Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
Sbjct: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120
Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
Sbjct: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180
Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
Sbjct: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240
Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
Sbjct: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300
Query: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
Sbjct: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360
Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
Sbjct: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420
Query: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV 480
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
Sbjct: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV 480
Query: 481 KAEYY 485
KAEYY
Sbjct: 481 KAEYY 485
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 962 bits (2488), Expect = 0.0
Identities = 481/481 (100%), Positives = 481/481 (100%)
Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
Sbjct: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120
Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
Sbjct: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180
Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
Sbjct: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240
Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
Sbjct: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300
Query: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
Sbjct: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360
Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
Sbjct: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420
Query: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV 480
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
Sbjct: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV 480
Query: 481 K 481
K
Sbjct: 481 K 481
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 639 bits (1648), Expect = 0.0
Identities = 297/439 (67%), Positives = 377/439 (85%)
Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 8 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67
Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
L EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 68 LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127
Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187
Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247
Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307
Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367
Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
S N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R
Sbjct: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427
Query: 425 CLLKSLKREGANKLRYPPN 443
CL++ L + K+RYPP+
Sbjct: 428 CLVRPLMNDEGLKVRYPPS 446
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 639 bits (1648), Expect = 0.0
Identities = 297/439 (67%), Positives = 377/439 (85%)
Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 8 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67
Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
L EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 68 LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127
Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187
Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247
Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307
Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367
Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
S N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R
Sbjct: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427
Query: 425 CLLKSLKREGANKLRYPPN 443
CL++ L + K+RYPP+
Sbjct: 428 CLVRPLMNDEGLKVRYPPS 446
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 639 bits (1648), Expect = 0.0
Identities = 297/439 (67%), Positives = 377/439 (85%)
Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 8 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67
Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
L EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 68 LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127
Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187
Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247
Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307
Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367
Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
S N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R
Sbjct: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427
Query: 425 CLLKSLKREGANKLRYPPN 443
CL++ L + K+RYPP+
Sbjct: 428 CLVRPLMNDEGLKVRYPPS 446
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 508 bits (1308), Expect = e-144
Identities = 245/444 (55%), Positives = 324/444 (72%)
Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
+RR+R+AF +GR+RP FR QL+ L R +QE ++ + A+A DL KS F EV
Sbjct: 8 LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAIS 67
Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
GE+ L NL W+ + V KN+ T LD A+I+ +P G+VLII WNYP LT+ PL+G
Sbjct: 68 QGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 127
Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
A+AAGN V++KPSE+S+N KILA++LPQY+DQ + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 128 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 187
Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
G+ VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD V R+ W +Y N GQTC+AP
Sbjct: 188 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 247
Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
DY+LC +Q +++ ++ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG
Sbjct: 248 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 307
Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
++DE+ RYIAPTVL DV VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 308 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 367
Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
S++ +++KR++ +TSSGG GND MH TL S PFGGVG+SGMG YHGK SFDTFSH R
Sbjct: 368 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 427
Query: 425 CLLKSLKREGANKLRYPPNSQSKV 448
CLL+S E N LRYPP S ++
Sbjct: 428 CLLRSPGMEKLNALRYPPQSPRRL 451
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 508 bits (1308), Expect = e-144
Identities = 245/444 (55%), Positives = 324/444 (72%)
Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
+RR+R+AF +GR+RP FR QL+ L R +QE ++ + A+A DL KS F EV
Sbjct: 8 LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAIS 67
Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
GE+ L NL W+ + V KN+ T LD A+I+ +P G+VLII WNYP LT+ PL+G
Sbjct: 68 QGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 127
Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
A+AAGN V++KPSE+S+N KILA++LPQY+DQ + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 128 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 187
Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
G+ VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD V R+ W +Y N GQTC+AP
Sbjct: 188 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 247
Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
DY+LC +Q +++ ++ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG
Sbjct: 248 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 307
Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
++DE+ RYIAPTVL DV VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 308 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 367
Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
S++ +++KR++ +TSSGG GND MH TL S PFGGVG+SGMG YHGK SFDTFSH R
Sbjct: 368 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 427
Query: 425 CLLKSLKREGANKLRYPPNSQSKV 448
CLL+S E N LRYPP S ++
Sbjct: 428 CLLRSPGMEKLNALRYPPQSPRRL 451
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 470 bits (1210), Expect = e-132
Identities = 232/444 (52%), Positives = 308/444 (69%), Gaps = 37/444 (8%)
Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
+RR+R+AF +GR+RP FR QL+ L R +QE ++ + A+A DL K+
Sbjct: 8 LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKA------------ 55
Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
T LD A+I+ +P G+VLII WNYP LT+ PL+G
Sbjct: 56 -------------------------TQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 90
Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
A+AAGN V++KPSE+S+N KILA++LPQY+DQ + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 91 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 150
Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
G+ VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD V R+ W +Y N GQTC+AP
Sbjct: 151 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 210
Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
DY+LC +Q +++ ++ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG
Sbjct: 211 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 270
Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
++DE+ RYIAPTVL DV VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 271 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 330
Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
S++ +++KR++ +TSSGG GND MH TL S PFGGVG+SGMG YHGK SFDTFSH R
Sbjct: 331 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 390
Query: 425 CLLKSLKREGANKLRYPPNSQSKV 448
CLL+S E N LRYPP S ++
Sbjct: 391 CLLRSPGMEKLNALRYPPQSPRRL 414
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 410 bits (1054), Expect = e-114
Identities = 195/373 (52%), Positives = 266/373 (71%), Gaps = 3/373 (0%)
Query: 82 KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE 141
+P N+ LD +I +P G+VLII WNYP LT+ L+GA+AAG+ V++KPSE+S+
Sbjct: 4 EPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQ 63
Query: 142 NTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHL 201
T K+LA++LPQYLDQ + V+ GG +ET +LL+ + D+IF+TG+ VGKIVM AA KHL
Sbjct: 64 GTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHL 123
Query: 202 TPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKI 261
TPVTLELGGK+PCY+D +CD V R+ W Y N GQTC+APDY+LC +Q +++ +
Sbjct: 124 TPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPAL 183
Query: 262 KETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDV 321
+ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG+++E+ RYIAPTVL DV
Sbjct: 184 QSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDV 243
Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381
VMQEEIFGPILPIV V++VDEAI FIN +EKPLALY FS++ +++ +M++ TSSG
Sbjct: 244 QETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSG 303
Query: 382 GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYP 441
GN+ + +L S PFGGVG SGMG YHGK +FDTFSH R CLL E ++ YP
Sbjct: 304 SFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHYP 363
Query: 442 PN---SQSKVDWG 451
P +Q + WG
Sbjct: 364 PYTDWNQQLLRWG 376
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 410 bits (1054), Expect = e-114
Identities = 195/373 (52%), Positives = 266/373 (71%), Gaps = 3/373 (0%)
Query: 82 KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE 141
+P N+ LD +I +P G+VLII WNYP LT+ L+GA+AAG+ V++KPSE+S+
Sbjct: 4 EPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQ 63
Query: 142 NTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHL 201
T K+LA++LPQYLDQ + V+ GG +ET +LL+ + D+IF+TG+ VGKIVM AA KHL
Sbjct: 64 GTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHL 123
Query: 202 TPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKI 261
TPVTLELGGK+PCY+D +CD V R+ W Y N GQTC+APDY+LC +Q +++ +
Sbjct: 124 TPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPAL 183
Query: 262 KETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDV 321
+ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG+++E+ RYIAPTVL DV
Sbjct: 184 QSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDV 243
Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381
VMQEEIFGPILPIV V++VDEAI FIN +EKPLALY FS++ +++ +M++ TSSG
Sbjct: 244 QETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSG 303
Query: 382 GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYP 441
GN+ + +L S PFGGVG SGMG YHGK +FDTFSH R CLL E ++ YP
Sbjct: 304 SFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHYP 363
Query: 442 PN---SQSKVDWG 451
P +Q + WG
Sbjct: 364 PYTDWNQQLLRWG 376
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 150 bits (378), Expect = 3e-36
Identities = 122/439 (27%), Positives = 209/439 (47%), Gaps = 30/439 (6%)
Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
+ L V+ + AF + R + L R+++ERE +I T + KS F
Sbjct: 75 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-- 132
Query: 61 VITVLGEIDFMLENLPEW--VTAKPVKKNV-LTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117
+ID + L + + A +++ L Y + +PLGV + IGAWNYPF +
Sbjct: 133 ------DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQI 186
Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ 176
A+A GNA++ KPS + +A +LA++ + + L+ V+ GG T + L Q
Sbjct: 187 ASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAA-TGQFLCQ 245
Query: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234
D + +TG+ G +ME +AK + PVTLELGGKSP I DCD++ + +
Sbjct: 246 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 305
Query: 235 MNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFYGENIKESPDYERIINLRHFKRILS 293
+ GQ C + + + ++ + +K+T + G+ + E +IN H +R+L
Sbjct: 306 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLG 365
Query: 294 LL-----EGQKIAFGGE----TDEATR---YIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341
+ +G K+ GG+ D + Y+ P VLT+ ++EEIFGP++ I+
Sbjct: 366 FVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILS 425
Query: 342 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGG 401
E + N+ LA VF+ + + R++ E +G N+ + + PFGG
Sbjct: 426 FDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGG 483
Query: 402 VGSSGMGAYHGKHSFDTFS 420
SG G +G+ + + +S
Sbjct: 484 YKKSGFGRENGRVTIEYYS 502
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 148 bits (374), Expect = 9e-36
Identities = 102/344 (29%), Positives = 169/344 (49%), Gaps = 13/344 (3%)
Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
+ + +P+GV I WN+P ++ + L A+ GN +++KP+E + TA L L+ +
Sbjct: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
Query: 156 DQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
+ I G T + + I +TG+T VGK+V EAA++ +L VTLELGGK
Sbjct: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270
+PC + D DLD+ G + N GQ C A + E + ++ V + E K+ G
Sbjct: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324
+ + I+ + F +IL L+ EG K+ GG ++ +I PTV ++V
Sbjct: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
++ +EEIFGP+ PI+ K+++E I N + L VF+ N ++ SG V
Sbjct: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
Query: 385 GNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
N + PFGG SG G G+++ ++ + +K
Sbjct: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 142 bits (357), Expect = 9e-34
Identities = 123/450 (27%), Positives = 210/450 (46%), Gaps = 32/450 (7%)
Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
+E V+ R+AF S SR + R + L + ++++ ++ A + D K+
Sbjct: 47 IEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTL------- 99
Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA----YIQPQPLGVVLIIGAWNYPFV 116
+ +I ++N + ++ + T +D Y P+GV +I WN P
Sbjct: 100 ALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLY 159
Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL- 174
L + A+AAGN VI KPSEL+ TA +L KLL + + + ++ G E L
Sbjct: 160 LLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALV 219
Query: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233
I +TG+ + + + +A H ++LELGGK+P I +D +LD
Sbjct: 220 SHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSS 279
Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESP--DYERIINLRHFKRI 291
+ N G+ C+ I + S+ ++ + + E ++ + I P +I+ H +++
Sbjct: 280 FANQGEICLCTSRIFVQKSIYSEFLKRFVEATRK-WKVGIPSDPLVSIGALISKAHLEKV 338
Query: 292 LS-----LLEGQKIAFGGETD--------EATRYIAPTVLTDVDPKTKVMQEEIFGPILP 338
S L EG +I G D +A ++ PTV+TD+ ++ M EEIFGP+
Sbjct: 339 RSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTC 398
Query: 339 IVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFP 398
+VP + +E I N + LA V+S N + R+ + SG V N ++ LN P
Sbjct: 399 VVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIR-ELN-LP 456
Query: 399 FGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
FGG+ SSG+G K S+D F+ + +K
Sbjct: 457 FGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 139 bits (350), Expect = 6e-33
Identities = 100/337 (29%), Positives = 172/337 (51%), Gaps = 15/337 (4%)
Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQY 154
+ + +PLGV II WNYP ++ +AAGN +++KP++++ TA A+L +
Sbjct: 579 FTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAG 638
Query: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGK 211
+ + +I G + L + D + +TG+T +GK +M++ A +L V+LELGGK
Sbjct: 639 FPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGK 698
Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270
SP I DC+LD R + N G+ CIA + E S+ ++ V ++ E +K+ G
Sbjct: 699 SPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIG 758
Query: 271 ENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPK 324
+ + S D+ + H +++L + EG + +GG + ++ PTV TDV+
Sbjct: 759 DPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDY 818
Query: 325 TKVMQEEIFGPILPIVPVKN--VDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382
+ +EE FGPI+ I +N +D + N E LA VF+ + + ++ +G
Sbjct: 819 MYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGT 878
Query: 383 VTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
V N + T + PFGGV SG G G+ + + +
Sbjct: 879 VFIN--TYNKTDVAAPFGGVKQSGFGKDLGEEALNEY 913
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 139 bits (349), Expect = 8e-33
Identities = 107/357 (29%), Positives = 169/357 (47%), Gaps = 18/357 (5%)
Query: 83 PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEN 142
P+ N T Y + +P+GV I WN+P V+ I + A++ GN V++KP+E +
Sbjct: 146 PIDGNFFT-----YTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200
Query: 143 TAKILAKLLPQYLDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK 199
TA +A L+ + + I G T D + +TG+T VGK++ EAA K
Sbjct: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260
Query: 200 -HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV 258
+L VTLELGGKSPC + D DLD G + + GQ CIA I E S+ ++ V
Sbjct: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320
Query: 259 WKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKI-AFGGETDEATR 311
+ E K++ G + I+ + +IL L+ EG K+ GG
Sbjct: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380
Query: 312 YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI 371
++ PTV ++V + ++ +EEIFGP+ I+ K++D+ I N L+ VF+ +
Sbjct: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440
Query: 372 KRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
+ +G V N PFGG SG G G++ F ++ + +K
Sbjct: 441 ITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 133 bits (334), Expect = 4e-31
Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%)
Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
Query: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
I I G T D I +TG+T VGK++ EAA + +L VTLELGGK
Sbjct: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270
SP I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPK 324
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V
Sbjct: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
++ +EEIFGP+ I+ K +DE I N + L VF+++ + +G V
Sbjct: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374
Query: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
N + LN+ PFGG SG G G+ +S + +K
Sbjct: 375 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 133 bits (334), Expect = 4e-31
Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%)
Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
Query: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
I I G T D I +TG+T VGK++ EAA + +L VTLELGGK
Sbjct: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270
SP I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPK 324
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V
Sbjct: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
++ +EEIFGP+ I+ K +DE I N + L VF+++ + +G V
Sbjct: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470
Query: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
N + LN+ PFGG SG G G+ +S + +K
Sbjct: 471 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 131 bits (329), Expect = 2e-30
Identities = 92/339 (27%), Positives = 160/339 (47%), Gaps = 16/339 (4%)
Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
A + QP+GV +I WN+P + + + A+AAG V++KP+E + +A LA+L Q
Sbjct: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247
Query: 155 -LDQDLYIVINGGVEETTEL-----LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLEL 208
+ +Y VI + E+ I +TG+T GKI++ AA + V++EL
Sbjct: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307
Query: 209 GGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE- 267
GG +P + ++D K+ N GQTC+ + L + + + V E +K+
Sbjct: 308 GGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKN 367
Query: 268 -FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE-ATRYIAPTVLTD 320
G +E +IN + +++ ++ +G + GG+ + + PT+L +
Sbjct: 368 LRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCN 427
Query: 321 VDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSS 380
V EE FGP+ P++ +EAI N + LA Y +S + I R+ ++
Sbjct: 428 VTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEV 487
Query: 381 GGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
G V N+ ++ PFGGV SG+G K+ D +
Sbjct: 488 GMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 524
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 127 bits (318), Expect = 3e-29
Identities = 99/347 (28%), Positives = 157/347 (45%), Gaps = 19/347 (5%)
Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY- 154
+ + +P+GV I WN+P V+ L A+A GN V++K +E + +A LA L+ +
Sbjct: 170 FTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAG 229
Query: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGK 211
+ +I G + Q D + +TG+T VG ++ +AA +L VTLELGGK
Sbjct: 230 FPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGK 289
Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE-FYG 270
SP + D D++ + + N GQ C A E S+ N+ + + E K+ G
Sbjct: 290 SPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVG 349
Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324
+ ++ F+R+L + EG K+ GGE E +I PTV V
Sbjct: 350 NPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDD 409
Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV- 383
++ +EEIFGP+ P+ K ++E + N LA VF+ + +G V
Sbjct: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
Query: 384 --TGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
T N V H PFGG SG G G+ ++ + +K
Sbjct: 470 VNTYNIVTCH-----TPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 511
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 125 bits (313), Expect = 1e-28
Identities = 92/352 (26%), Positives = 162/352 (46%), Gaps = 29/352 (8%)
Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
A + QP+GV +I WN+P + + + A+AAG V++KP+E + +A LA++ +
Sbjct: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGF 247
Query: 155 L-DQDLYIV-----INGGVEETTELLKQR-------------FDHIFYTGNTAVGKIVME 195
L D D ++ I GV ++ I +TG+T GKI++
Sbjct: 248 LLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 307
Query: 196 AAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN 255
AA + V++ELGG +P + ++D K+ N GQTC+ + L + + +
Sbjct: 308 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 367
Query: 256 QIVWKIKETVKE--FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE 308
V E +K+ G +E +IN + +++ ++ +G + GG+ +
Sbjct: 368 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 427
Query: 309 -ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHN 367
+ PT+L +V EE FGP+ P++ +EAI N + LA Y +S +
Sbjct: 428 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 487
Query: 368 HKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
I R+ ++ G V N+ ++ PFGGV SG+G K+ D +
Sbjct: 488 PAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 537
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 123 bits (308), Expect = 4e-28
Identities = 98/333 (29%), Positives = 164/333 (49%), Gaps = 15/333 (4%)
Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQD 158
+P+GV II WNYP ++ +AAGN V+IKP++++ TA A+L L + +
Sbjct: 562 EPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKG 621
Query: 159 LYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGKSPCY 215
+ V+ G + L D I +TG+T VGK +M++ A ++ V+LELGGKSP
Sbjct: 622 VVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLI 681
Query: 216 IDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIK 274
I DCDL+ + + N G+ CIA + E S+ ++ V ++ E V++ G +
Sbjct: 682 IFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLD 741
Query: 275 ESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPKTKVM 328
D+ + H +++ + EG + GG + + PTV TDV+ +
Sbjct: 742 RDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIA 801
Query: 329 QEEIFGPILPIVPVK--NVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGN 386
+EE FGP++ I ++D ++ N E LA VF+ + + D+ +G V N
Sbjct: 802 KEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN 861
Query: 387 DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
+ T + PFGG SG G G+ + + +
Sbjct: 862 --TYNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 122 bits (307), Expect = 6e-28
Identities = 98/347 (28%), Positives = 158/347 (45%), Gaps = 17/347 (4%)
Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
+Y + +P+GV I WN+P ++ L A+A GN V++K +E + TA +A L+ +
Sbjct: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228
Query: 155 LDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAA-AKHLTPVTLELGG 210
+ I G T + D + +TG+T +G+++ AA + +L VTLELGG
Sbjct: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288
Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFY 269
KSP I D D+D + + + N GQ C A + + ++ V + +
Sbjct: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348
Query: 270 GENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETDEATRY-IAPTVLTDVDP 323
G + ++ FK+IL + EG K+ GG Y I PTV DV
Sbjct: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408
Query: 324 KTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV 383
+ +EEIFGP++ I+ K ++E + N LA VF+ + + +G V
Sbjct: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
Query: 384 TGN--DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
N DV F S PFGG SG G G++ ++ + +K
Sbjct: 469 WVNCYDV---FGAQS-PFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 118 bits (296), Expect = 1e-26
Identities = 118/439 (26%), Positives = 195/439 (44%), Gaps = 64/439 (14%)
Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
+E V+ R+AF S SR + R + L + ++++ ++ A + D K+
Sbjct: 47 IEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTL------- 99
Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA----YIQPQPLGVVLIIGAWNYPFV 116
+ +I ++N + ++ + T +D Y P+GV +I WN P
Sbjct: 100 ALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLY 159
Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL- 174
L + A+AAGN VI KPSEL+ TA +L KLL + + + ++ G E L
Sbjct: 160 LLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALV 219
Query: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233
I +TG+ + + + +A H ++LELGGK+P I +D +LD
Sbjct: 220 SHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLD---------- 269
Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE----FYGENIKESPDYERIINLRHFK 289
CI +S NQ+ +K + E + GE + +
Sbjct: 270 ------ECIP---ATVRSSFANQVRSYVKRALAEGAQIWCGEGVDK-------------- 306
Query: 290 RILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAI 349
LSL ++A ++ PTV+TD+ ++ M EEIFGP+ +VP + +E I
Sbjct: 307 --LSL---------PARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVI 355
Query: 350 NFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA 409
N + LA V+S N + R+ + SG V N ++ LN PFGG+ SSG+G
Sbjct: 356 ERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIR-ELN-LPFGGMKSSGIGR 413
Query: 410 YHGKHSFDTFSHQRPCLLK 428
K S+D F+ + +K
Sbjct: 414 EGAKDSYDFFTEIKTITVK 432
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 117 bits (294), Expect = 2e-26
Identities = 96/342 (28%), Positives = 151/342 (44%), Gaps = 47/342 (13%)
Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
Query: 156 DQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPC 214
VGK++ EAA + +L VTLELGGKSP
Sbjct: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
Query: 215 YIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYGENI 273
I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
Query: 274 KESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPKTKV 327
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V ++
Sbjct: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
Query: 328 MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGND 387
+EEIFGP+ I+ K +DE I N + L VF+++ + +G V N
Sbjct: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434
Query: 388 VIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
+ LN+ PFGG SG G G+ +S + +K
Sbjct: 435 --CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 93.6 bits (231), Expect = 4e-19
Identities = 101/455 (22%), Positives = 185/455 (40%), Gaps = 32/455 (7%)
Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAAD----LCKSEFNV 56
M+ + ++AF + + R Q L +++++E K+I I + L +E +V
Sbjct: 79 MDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDV 138
Query: 57 YSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFV 116
+ + E + +L T + K++ + Y PLGV I +N+P +
Sbjct: 139 FRGLQVV---EHACSVTSLMMGETMPSITKDM-----DLYSYRLPLGVCAGIAPFNFPAM 190
Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQ 176
+ + A+ GN ++KPSE +LAKLL D + I G E +
Sbjct: 191 IPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICD 250
Query: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234
D I + G+ G+ + E ++H V +G K+ + D + + ++ +
Sbjct: 251 HPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAF 310
Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSL 294
GQ C+A + + + ++ + D +I + +R+ +L
Sbjct: 311 GAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNL 370
Query: 295 ------------LEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPV 342
L+G+KI G E ++ PT++++V P +EEIFGP+L ++
Sbjct: 371 IDSGTKEGASILLDGRKIKVKGY--ENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLET 428
Query: 343 KNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGV 402
+ +DEAI +N +F+ N ++ G V G +V + L F F G
Sbjct: 429 ETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQV-GVNVPIPVPLPMFSFTGS 487
Query: 403 GSSGMG--AYHGKHSFDTFSHQRPCLLKSLKREGA 435
SS G ++GK F Q + K E A
Sbjct: 488 RSSFRGDTNFYGKQGIQ-FYTQLKTITSQWKEEDA 521
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 90.9 bits (224), Expect = 2e-18
Identities = 85/351 (24%), Positives = 150/351 (42%), Gaps = 20/351 (5%)
Query: 98 QPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIK----PSELSENTAKILAKLLPQ 153
Q P+G+V II A+N+P + A+ GN + K S +S KI+AK+L
Sbjct: 181 QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED 240
Query: 154 Y-LDQDLYIVINGGVEETTELLK-QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211
L + + GG + T + K +R + + +TG+T VGK V + LELGG
Sbjct: 241 NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN 300
Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271
+ +D DL +V + GQ C + S+ +++V ++K+ +
Sbjct: 301 NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQI--- 357
Query: 272 NIKESPDYERIINLRHFKRILSLL---------EGQKIAFGGET-DEATRYIAPTVLTDV 321
+ D + H K+ +S+ EG + +GG+ D Y+ PT++T +
Sbjct: 358 RVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGL 417
Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381
+ E F PIL + KN +E + NE ++ L+ +F+ + I R + S
Sbjct: 418 GHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 477
Query: 382 -GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK 431
G+ ++ FGG +G G G ++ + + C + K
Sbjct: 478 CGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSK 528
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)
Query: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175
L GA A GN V+ KPS+ + + + ++L P + Q ++ +G + T
Sbjct: 219 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 276
Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229
+ I +TG+ K + + A++L + E GGK+ ++ + D++ V
Sbjct: 277 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 336
Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287
+ GQ C A + SL QI ++ E G+ ++ + +I+ +
Sbjct: 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 396
Query: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338
F RI LE + I GG+ D++ Y + P ++ DP+ +M+EEIFGP+L
Sbjct: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456
Query: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395
+ P E + ++ L VFS + +++ + ++G ND +
Sbjct: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516
Query: 396 SFPFGGVGSSG 406
PFGG +SG
Sbjct: 517 QQPFGGARASG 527
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)
Query: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175
L GA A GN V+ KPS+ + + + ++L P + Q ++ +G + T
Sbjct: 159 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 216
Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229
+ I +TG+ K + + A++L + E GGK+ ++ + D++ V
Sbjct: 217 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 276
Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287
+ GQ C A + SL QI ++ E G+ ++ + +I+ +
Sbjct: 277 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 336
Query: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338
F RI LE + I GG+ D++ Y + P ++ DP+ +M+EEIFGP+L
Sbjct: 337 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 396
Query: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395
+ P E + ++ L VFS + +++ + ++G ND +
Sbjct: 397 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 456
Query: 396 SFPFGGVGSSG 406
PFGG +SG
Sbjct: 457 QQPFGGARASG 467
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)
Query: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175
L GA A GN V+ KPS+ + + + ++L P + Q ++ +G + T
Sbjct: 219 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 276
Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229
+ I +TG+ K + + A++L + E GGK+ ++ + D++ V
Sbjct: 277 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 336
Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287
+ GQ C A + SL QI ++ E G+ ++ + +I+ +
Sbjct: 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 396
Query: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338
F RI LE + I GG+ D++ Y + P ++ DP+ +M+EEIFGP+L
Sbjct: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456
Query: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395
+ P E + ++ L VFS + +++ + ++G ND +
Sbjct: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516
Query: 396 SFPFGGVGSSG 406
PFGG +SG
Sbjct: 517 QQPFGGARASG 527
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 38.1 bits (87), Expect = 0.018
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 2/112 (1%)
Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDL 159
+PLGV+ ++ +P + + L A+A GN V++ PS A + + + L
Sbjct: 608 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGL 667
Query: 160 YIVINGGVEETTE--LLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209
V+ G + T L Q ++Y G+ + V A+A +L PV G
Sbjct: 668 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,633,898
Number of Sequences: 37866
Number of extensions: 780340
Number of successful extensions: 1864
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1772
Number of HSP's gapped (non-prelim): 43
length of query: 485
length of database: 18,247,518
effective HSP length: 106
effective length of query: 379
effective length of database: 14,233,722
effective search space: 5394580638
effective search space used: 5394580638
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.