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Search of human proteins with 4557267
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
(408 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 836 0.0
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 375 e-104
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 314 8e-86
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 215 5e-56
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 214 1e-55
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 202 6e-52
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 202 6e-52
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 202 6e-52
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 202 6e-52
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 197 2e-50
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 192 4e-49
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 192 4e-49
gi|4503383 dopamine receptor D1 [Homo sapiens] 191 8e-49
gi|4503391 dopamine receptor D5 [Homo sapiens] 189 3e-48
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 186 4e-47
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 177 2e-44
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 177 2e-44
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 177 2e-44
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 171 1e-42
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 171 1e-42
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 171 1e-42
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 171 1e-42
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 171 1e-42
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 171 1e-42
gi|32483397 dopamine receptor D4 [Homo sapiens] 170 2e-42
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 167 1e-41
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 166 4e-41
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 162 5e-40
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 156 4e-38
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 155 5e-38
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 836 bits (2160), Expect = 0.0
Identities = 408/408 (100%), Positives = 408/408 (100%)
Query: 1 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV 60
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
Sbjct: 1 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV 60
Query: 61 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC 120
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
Sbjct: 61 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC 120
Query: 121 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV 180
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
Sbjct: 121 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV 180
Query: 181 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG 240
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
Sbjct: 181 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG 240
Query: 241 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT 300
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
Sbjct: 241 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT 300
Query: 301 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL 360
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
Sbjct: 301 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL 360
Query: 361 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS 408
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Sbjct: 361 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS 408
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 375 bits (962), Expect = e-104
Identities = 215/416 (51%), Positives = 259/416 (62%), Gaps = 30/416 (7%)
Query: 5 PHENSSLAPWPD-----LPTLAPNTANTSGLPGVP---------WEAALAGALLALAVLA 50
P SS AP PD L P + S LP W A + G L+AL VL
Sbjct: 13 PGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGM-GLLMALIVLL 71
Query: 51 TVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGC 110
V GN+LVIVAIA TPRLQT+TN+F+ SLA+ADLVMGLLVVP AT+ + G W G+ C
Sbjct: 72 IVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFC 131
Query: 111 ELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSF 170
ELWTSVDVLCVTASIETLC +A+DRYLA+T+P RY +L+T+ AR V VW +SA VSF
Sbjct: 132 ELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSF 191
Query: 171 APIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVV 230
PI+ WWR +D EA+RC+++P+CC F +N Y + SS VSFY+PL +M FVY RVF
Sbjct: 192 LPILMHWWRAESD-EARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFRE 250
Query: 231 ATRQLRLLRGELGRF-PPEESPPAPSRSLAPAPVGTCAPPEGVPACG-----------RR 278
A +Q++ + RF PP+PS S PAP PP A RR
Sbjct: 251 AQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRR 310
Query: 279 PARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYAN 338
P+RL+ LRE +AL TLG+IMG FTLCWLPFFLANV++A LVP F+ NWLGYAN
Sbjct: 311 PSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF-HRELVPDRLFVFFNWLGYAN 369
Query: 339 SAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQP 394
SAFNP+IYCRSPDFR AF+ LLC C RR A SG A P P
Sbjct: 370 SAFNPIIYCRSPDFRKAFQGLLC-CARRAARRRHATHGDRPRASGCLARPGPPPSP 424
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 314 bits (805), Expect = 8e-86
Identities = 163/321 (50%), Positives = 208/321 (64%), Gaps = 16/321 (4%)
Query: 41 GALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALT 100
G +++L VLA V GN+LVI AIA RLQT+TN F+TSLA ADLVMGL VVP A L
Sbjct: 37 GIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILM 96
Query: 101 GHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVL 160
W G CE WTS+DVLCVTASIETLC +AVDRY A+T+P +Y +L+TK AR +++
Sbjct: 97 KMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILM 156
Query: 161 VWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVM 220
VW+VS SF PI W+R EA C++N CC F +N Y + SS VSFY+PL++M
Sbjct: 157 VWIVSGLTSFLPIQMHWYR-ATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIM 215
Query: 221 LFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPA 280
+FVY+RVF A RQL+ + GRF + +G G R +
Sbjct: 216 VFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQ--------------DGRTGHGLRRS 261
Query: 281 RLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSA 340
L+EH+AL TLG+IMGTFTLCWLPFF+ N++ + +L+ ++ LNW+GY NS
Sbjct: 262 SKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVI-QDNLIRKEVYILLNWIGYVNSG 320
Query: 341 FNPLIYCRSPDFRSAFRRLLC 361
FNPLIYCRSPDFR AF+ LLC
Sbjct: 321 FNPLIYCRSPDFRIAFQELLC 341
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 215 bits (548), Expect = 5e-56
Identities = 137/374 (36%), Positives = 205/374 (54%), Gaps = 22/374 (5%)
Query: 6 HENSSLAPWPDLPTL---APN-TANTSGLPGVPWEAALA-GALLALAVLATVGGNLLVIV 60
H S+ A W +L PN T++ S LP + A++ G +L +L + GN+LVI+
Sbjct: 9 HNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVIL 68
Query: 61 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC 120
++A L+T TN F+ +LA ADL++ V+P +A L + G+W LG C++W +VDVLC
Sbjct: 69 SVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLC 128
Query: 121 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV 180
TASI +LCA+++DRY+ V L+Y LVT+R A A++ VWV+S +S P++ W+
Sbjct: 129 CTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLG--WKE 186
Query: 181 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG 240
A ++ + C Y L SS SFY+PL V+L +Y RV++VA R + L
Sbjct: 187 PAP-------NDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEA 239
Query: 241 ELGR---FPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLI 297
+ + E + S++ + + P RE +A TLG++
Sbjct: 240 GVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIV 299
Query: 298 MGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY-CRSPDFRSAF 356
+G F LCWLPFF+A L +L P F + WLGY NS NP+IY C S +F+ AF
Sbjct: 300 VGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAF 359
Query: 357 RRLL-CRC---GRR 366
R+L C+C GRR
Sbjct: 360 VRILGCQCRGRGRR 373
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 214 bits (545), Expect = 1e-55
Identities = 142/363 (39%), Positives = 193/363 (53%), Gaps = 32/363 (8%)
Query: 24 TANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAAD 83
TA GL V + G LA +L V GNLLVI+++A LQT+TN F+ +LA AD
Sbjct: 84 TAAVGGLV-VSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVAD 142
Query: 84 LVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPL 143
L++ V+P +AT+ + G W G C++W +VDVLC TASI +LC ++VDRY+ V + L
Sbjct: 143 LLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSL 202
Query: 144 RYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMP 203
+Y A++T+R A + L+WVV+ VS P++ W+ + + R C
Sbjct: 203 KYPAIMTERKAAAILALLWVVALVVSVGPLLG--WK-------EPVPPDERFCGITEEAG 253
Query: 204 YVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPV 263
Y + SS SFYLP+ V++ +Y RV+VVA R L + R E A L
Sbjct: 254 YAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKR----ERGKASEVVLRIHCR 309
Query: 264 GTCAPPEGVPACGRRPA-----------RLLPL-REHRALCTLGLIMGTFTLCWLPFFLA 311
G +G A G R A RLL RE +A TL +++G F LCW PFF
Sbjct: 310 GAATGADG--AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFV 367
Query: 312 NVLRALGGPSLVPGP-AFLALNWLGYANSAFNPLIY-CRSPDFRSAFRRLL-CRCGRRLP 368
L +L P L P F + WLGY NS NPLIY C S +F+ AF RLL C+C RR
Sbjct: 368 LPLGSL-FPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
Query: 369 PEP 371
P
Sbjct: 427 RRP 429
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 202 bits (513), Expect = 6e-52
Identities = 120/335 (35%), Positives = 176/335 (52%), Gaps = 13/335 (3%)
Query: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAA 95
+A L G +L +L V GN+LVI+++A L ++T+ ++ +LA ADL++ V+P +A
Sbjct: 25 KAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84
Query: 96 TLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCAR 155
+ G+W G C +W +VDVLC TASI LC +++DRY+ V+ PLRY +VT+R
Sbjct: 85 IFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGL 144
Query: 156 TAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYL 215
A++ VW +S +S P+ WR A + C N YVL S+ SFYL
Sbjct: 145 MALLCVWALSLVISIGPLFG--WRQPAPEDETICQIN-------EEPGYVLFSALGSFYL 195
Query: 216 PLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC 275
PL ++L +Y RV+VVA R+ R L+ L + AP G
Sbjct: 196 PLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKT 255
Query: 276 GRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLG 335
L RE +A TLG+++G F LCWLPFFL + + F + WLG
Sbjct: 256 HFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLG 315
Query: 336 YANSAFNPLIY-CRSPDFRSAFR---RLLCRCGRR 366
Y NS NP+IY C S +F+ AF+ R+ C C ++
Sbjct: 316 YLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 202 bits (513), Expect = 6e-52
Identities = 120/335 (35%), Positives = 176/335 (52%), Gaps = 13/335 (3%)
Query: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAA 95
+A L G +L +L V GN+LVI+++A L ++T+ ++ +LA ADL++ V+P +A
Sbjct: 25 KAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84
Query: 96 TLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCAR 155
+ G+W G C +W +VDVLC TASI LC +++DRY+ V+ PLRY +VT+R
Sbjct: 85 IFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGL 144
Query: 156 TAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYL 215
A++ VW +S +S P+ WR A + C N YVL S+ SFYL
Sbjct: 145 MALLCVWALSLVISIGPLFG--WRQPAPEDETICQIN-------EEPGYVLFSALGSFYL 195
Query: 216 PLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC 275
PL ++L +Y RV+VVA R+ R L+ L + AP G
Sbjct: 196 PLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKT 255
Query: 276 GRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLG 335
L RE +A TLG+++G F LCWLPFFL + + F + WLG
Sbjct: 256 HFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLG 315
Query: 336 YANSAFNPLIY-CRSPDFRSAFR---RLLCRCGRR 366
Y NS NP+IY C S +F+ AF+ R+ C C ++
Sbjct: 316 YLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 202 bits (513), Expect = 6e-52
Identities = 120/335 (35%), Positives = 176/335 (52%), Gaps = 13/335 (3%)
Query: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAA 95
+A L G +L +L V GN+LVI+++A L ++T+ ++ +LA ADL++ V+P +A
Sbjct: 25 KAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84
Query: 96 TLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCAR 155
+ G+W G C +W +VDVLC TASI LC +++DRY+ V+ PLRY +VT+R
Sbjct: 85 IFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGL 144
Query: 156 TAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYL 215
A++ VW +S +S P+ WR A + C N YVL S+ SFYL
Sbjct: 145 MALLCVWALSLVISIGPLFG--WRQPAPEDETICQIN-------EEPGYVLFSALGSFYL 195
Query: 216 PLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC 275
PL ++L +Y RV+VVA R+ R L+ L + AP G
Sbjct: 196 PLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKT 255
Query: 276 GRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLG 335
L RE +A TLG+++G F LCWLPFFL + + F + WLG
Sbjct: 256 HFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLG 315
Query: 336 YANSAFNPLIY-CRSPDFRSAFR---RLLCRCGRR 366
Y NS NP+IY C S +F+ AF+ R+ C C ++
Sbjct: 316 YLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 202 bits (513), Expect = 6e-52
Identities = 120/335 (35%), Positives = 176/335 (52%), Gaps = 13/335 (3%)
Query: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAA 95
+A L G +L +L V GN+LVI+++A L ++T+ ++ +LA ADL++ V+P +A
Sbjct: 25 KAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84
Query: 96 TLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCAR 155
+ G+W G C +W +VDVLC TASI LC +++DRY+ V+ PLRY +VT+R
Sbjct: 85 IFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGL 144
Query: 156 TAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYL 215
A++ VW +S +S P+ WR A + C N YVL S+ SFYL
Sbjct: 145 MALLCVWALSLVISIGPLFG--WRQPAPEDETICQIN-------EEPGYVLFSALGSFYL 195
Query: 216 PLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC 275
PL ++L +Y RV+VVA R+ R L+ L + AP G
Sbjct: 196 PLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKT 255
Query: 276 GRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLG 335
L RE +A TLG+++G F LCWLPFFL + + F + WLG
Sbjct: 256 HFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLG 315
Query: 336 YANSAFNPLIY-CRSPDFRSAFR---RLLCRCGRR 366
Y NS NP+IY C S +F+ AF+ R+ C C ++
Sbjct: 316 YLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 197 bits (500), Expect = 2e-50
Identities = 132/382 (34%), Positives = 194/382 (50%), Gaps = 31/382 (8%)
Query: 18 PTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVT 77
PT A +G P P + A L + + T N L+I I P L+ +N F+
Sbjct: 7 PTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLV 66
Query: 78 SLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYL 137
SL +DL++GL+V+PPA AL G W L C LWT+ DV+C +ASI LC +++DRYL
Sbjct: 67 SLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYL 126
Query: 138 AVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRC-- 195
+ +PLRY +T A V+ W ++A SF P++ W +G H+ P
Sbjct: 127 LILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELG--------HARPPVPG 178
Query: 196 -CAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAP 254
C +++P+VL++S ++F+LP + F Y R+ + A +Q ++ + A
Sbjct: 179 QCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQ----AVQVASLTTGMASQAS 234
Query: 255 SRSLAPAPVGTCAPPEGV-PACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANV 313
P P GV A RR A + +A TLG+++G F + WLPFF+AN+
Sbjct: 235 ETLQVPR-----TPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANI 289
Query: 314 LRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCA 373
++A+ + PG F L WLGY NS NP+IY P F F+R L GR LP C
Sbjct: 290 VQAV-CDCISPG-LFDVLTWLGYCNSTMNPIIY---PLFMRDFKRAL---GRFLPCPRCP 341
Query: 374 AARPALFPSGVPAARSSPAQPR 395
R A S P+ R+S + PR
Sbjct: 342 RERQASLAS--PSLRTSHSGPR 361
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 192 bits (489), Expect = 4e-49
Identities = 119/344 (34%), Positives = 177/344 (51%), Gaps = 42/344 (12%)
Query: 20 LAPN-TANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTS 78
+APN TA++ L + + +LA+ +L TV GN++V +A+ RL+ +TN F+ S
Sbjct: 1 MAPNGTASSFCLDSTACKITIT-VVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVS 59
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA DL++GLLV+P +A L+ W G C ++TS+DV+ TASI L +++DRY A
Sbjct: 60 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA 119
Query: 139 VTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAF 198
V +PLRY LVT ++VL+WV+S +SF I W + E + + C
Sbjct: 120 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGW---NSRNETSKGNHTTSKCKV 176
Query: 199 ASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSL 258
N Y L+ V+FYLPLL+M Y R+F VA Q + + +
Sbjct: 177 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRI-----------------NHI 219
Query: 259 APAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALG 318
+ T +REH+A TL +MG F +CW P+F A V R L
Sbjct: 220 SSWKAAT-------------------IREHKATVTLAAVMGAFIICWFPYFTAFVYRGLR 260
Query: 319 GPSLVPGPAFLALNWLGYANSAFNPLIYCR-SPDFRSAFRRLLC 361
G + + WLGYANSA NP++Y + DFR+ +++L C
Sbjct: 261 GDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFC 304
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 192 bits (489), Expect = 4e-49
Identities = 119/344 (34%), Positives = 177/344 (51%), Gaps = 42/344 (12%)
Query: 20 LAPN-TANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTS 78
+APN TA++ L + + +LA+ +L TV GN++V +A+ RL+ +TN F+ S
Sbjct: 1 MAPNGTASSFCLDSTACKITIT-VVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVS 59
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA DL++GLLV+P +A L+ W G C ++TS+DV+ TASI L +++DRY A
Sbjct: 60 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA 119
Query: 139 VTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAF 198
V +PLRY LVT ++VL+WV+S +SF I W + E + + C
Sbjct: 120 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGW---NSRNETSKGNHTTSKCKV 176
Query: 199 ASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSL 258
N Y L+ V+FYLPLL+M Y R+F VA Q + + +
Sbjct: 177 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRI-----------------NHI 219
Query: 259 APAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALG 318
+ T +REH+A TL +MG F +CW P+F A V R L
Sbjct: 220 SSWKAAT-------------------IREHKATVTLAAVMGAFIICWFPYFTAFVYRGLR 260
Query: 319 GPSLVPGPAFLALNWLGYANSAFNPLIYCR-SPDFRSAFRRLLC 361
G + + WLGYANSA NP++Y + DFR+ +++L C
Sbjct: 261 GDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFC 304
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 191 bits (486), Expect = 8e-49
Identities = 126/392 (32%), Positives = 190/392 (48%), Gaps = 36/392 (9%)
Query: 24 TANTSGLPGVPWEAA-------LAGALLALAVLATVGGNLLVIVAIAWTPRLQT-MTNVF 75
T NTS + G L L+L +L+T+ GN LV A+ L++ +TN F
Sbjct: 3 TLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFF 62
Query: 76 VTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDR 135
V SLA +DL++ +LV+P A + G WP G+ C +W + D++C TASI LC ++VDR
Sbjct: 63 VISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDR 121
Query: 136 YLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV----GADAEAQRCHS 191
Y A+++P RY +T + A + + W +S +SF P+ W + +D A
Sbjct: 122 YWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAE 181
Query: 192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESP 251
C + + Y + SS +SFY+P+ +M+ Y R++ +A +Q+R +
Sbjct: 182 TIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI------------- 228
Query: 252 PAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPL---REHRALCTLGLIMGTFTLCWLPF 308
A R+ A G P +P + RE + L TL +IMG F CWLPF
Sbjct: 229 AALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPF 288
Query: 309 FLANVLRALGG-----PSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRC 363
F+ N + G P + F W G+ANS+ NP+IY + DFR AF LL C
Sbjct: 289 FILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLL-GC 347
Query: 364 GRRLPPEPCAAARPALFPSGVPAARSSPAQPR 395
R P A ++ +G A SS +PR
Sbjct: 348 YRLCPATNNAIETVSINNNGA-AMFSSHHEPR 378
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 189 bits (481), Expect = 3e-48
Identities = 119/362 (32%), Positives = 178/362 (49%), Gaps = 46/362 (12%)
Query: 27 TSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQT-MTNVFVTSLAAADLV 85
++G P + + LL L ++ T+ GN+LV AI + L+ MTNVF+ SLA +DL
Sbjct: 30 SAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLF 89
Query: 86 MGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRY 145
+ LLV+P A + G+WP GA C++W + D++C TASI LC ++VDRY A++ P RY
Sbjct: 90 VALLVMPWKAVAEVAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRY 148
Query: 146 GALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGA------------------DAEAQ 187
+T+R A V L W +S +SF P+ W R A + +
Sbjct: 149 KRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFW 208
Query: 188 RCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPP 247
N C + N Y + SS +SFY+P+ +M+ Y R++ +A Q+R + L R
Sbjct: 209 EPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRI-SSLER--- 264
Query: 248 EESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLP 307
A + + CAP + A + +E + L TL +IMG F CWLP
Sbjct: 265 -----AAEHAQSCRSSAACAPDTSLRASIK--------KETKVLKTLSVIMGVFVCCWLP 311
Query: 308 FFLANVLRAL---------GGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRR 358
FF+ N + G V F W G+ANS+ NP+IY + DF+ F +
Sbjct: 312 FFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQ 371
Query: 359 LL 360
LL
Sbjct: 372 LL 373
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 186 bits (471), Expect = 4e-47
Identities = 118/350 (33%), Positives = 176/350 (50%), Gaps = 33/350 (9%)
Query: 33 VPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVP 92
+PW+ L LLAL LAT N VI + T +L T N + SLA DL++ +LV+P
Sbjct: 46 LPWKVLLV-MLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMP 104
Query: 93 PAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKR 152
+ +TG W LG C+ W S D+ C TASI LC +A+DRY A+T+ + Y A T +
Sbjct: 105 ISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPK 164
Query: 153 CARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVS 212
A + LVWV S ++S P W + A+ E C N ++ Y + S+ +
Sbjct: 165 RAAVMIALVWVFSISISLPPFF--WRQAKAEEEVSECVVN------TDHILYTVYSTVGA 216
Query: 213 FYLPLLVMLFVYARVFVVATRQL----------RLLRGELGRFPPEES----------PP 252
FY P L+++ +Y R++V A ++ RL R +L P + P
Sbjct: 217 FYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPD 276
Query: 253 APSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLAN 312
PS S +P V ++ +L+ RE +A TLG+I+G F +CWLPFF+ +
Sbjct: 277 VPSESGSPVYVNQVKVRVSDALLEKK--KLMAARERKATKTLGIILGAFIVCWLPFFIIS 334
Query: 313 VLRALGGPSLVPGPA-FLALNWLGYANSAFNPLIYCRS-PDFRSAFRRLL 360
++ + + A F WLGY NS NP+IY S DF+ AF +L+
Sbjct: 335 LVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 177 bits (449), Expect = 2e-44
Identities = 107/333 (32%), Positives = 172/333 (51%), Gaps = 21/333 (6%)
Query: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVP-PA 94
E + G++L L L T+ GN LV++++ + +L+ +N + SLA ADL + + V+P +
Sbjct: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139
Query: 95 ATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCA 154
T + G W G C ++ ++DV+C TASI TLC +++DRYL +T PL Y +C
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 155 RTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFY 214
++ VW++SA+++ P+ V D + C + + Y + S++V+FY
Sbjct: 200 AKMILSVWLLSASITLPPLFGWAQNVNDD----------KVCLISQDFGYTIYSTAVAFY 249
Query: 215 LPLLVMLFVYARVFVVATRQLRLLRGELGRFP---PEESPPAPSRSLAPAPVGTCAPPEG 271
+P+ VMLF+Y +++ A + + + FP P+ V CA
Sbjct: 250 IPMSVMLFMYYQIYKAARKS--AAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSR 307
Query: 272 VPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRAL---GGPSLVPGPAF 328
+ R+ + RE +A TLG+I+G FT+CWLPFFL + R S +P
Sbjct: 308 LLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVE 366
Query: 329 LALNWLGYANSAFNPLIYC-RSPDFRSAFRRLL 360
WLGYANS NP IY + D R+ +R LL
Sbjct: 367 RTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 177 bits (449), Expect = 2e-44
Identities = 107/333 (32%), Positives = 172/333 (51%), Gaps = 21/333 (6%)
Query: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVP-PA 94
E + G++L L L T+ GN LV++++ + +L+ +N + SLA ADL + + V+P +
Sbjct: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139
Query: 95 ATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCA 154
T + G W G C ++ ++DV+C TASI TLC +++DRYL +T PL Y +C
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 155 RTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFY 214
++ VW++SA+++ P+ V D + C + + Y + S++V+FY
Sbjct: 200 AKMILSVWLLSASITLPPLFGWAQNVNDD----------KVCLISQDFGYTIYSTAVAFY 249
Query: 215 LPLLVMLFVYARVFVVATRQLRLLRGELGRFP---PEESPPAPSRSLAPAPVGTCAPPEG 271
+P+ VMLF+Y +++ A + + + FP P+ V CA
Sbjct: 250 IPMSVMLFMYYQIYKAARKS--AAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSR 307
Query: 272 VPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRAL---GGPSLVPGPAF 328
+ R+ + RE +A TLG+I+G FT+CWLPFFL + R S +P
Sbjct: 308 LLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVE 366
Query: 329 LALNWLGYANSAFNPLIYC-RSPDFRSAFRRLL 360
WLGYANS NP IY + D R+ +R LL
Sbjct: 367 RTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 177 bits (449), Expect = 2e-44
Identities = 107/333 (32%), Positives = 172/333 (51%), Gaps = 21/333 (6%)
Query: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVP-PA 94
E + G++L L L T+ GN LV++++ + +L+ +N + SLA ADL + + V+P +
Sbjct: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139
Query: 95 ATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCA 154
T + G W G C ++ ++DV+C TASI TLC +++DRYL +T PL Y +C
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 155 RTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFY 214
++ VW++SA+++ P+ V D + C + + Y + S++V+FY
Sbjct: 200 AKMILSVWLLSASITLPPLFGWAQNVNDD----------KVCLISQDFGYTIYSTAVAFY 249
Query: 215 LPLLVMLFVYARVFVVATRQLRLLRGELGRFP---PEESPPAPSRSLAPAPVGTCAPPEG 271
+P+ VMLF+Y +++ A + + + FP P+ V CA
Sbjct: 250 IPMSVMLFMYYQIYKAARKS--AAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSR 307
Query: 272 VPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRAL---GGPSLVPGPAF 328
+ R+ + RE +A TLG+I+G FT+CWLPFFL + R S +P
Sbjct: 308 LLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVE 366
Query: 329 LALNWLGYANSAFNPLIYC-RSPDFRSAFRRLL 360
WLGYANS NP IY + D R+ +R LL
Sbjct: 367 RTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 171 bits (432), Expect = 1e-42
Identities = 124/380 (32%), Positives = 182/380 (47%), Gaps = 42/380 (11%)
Query: 20 LAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTM-TNVFVTS 78
L N ++ G V E + L+ +L + GNLLV+VA+ W +L+ + TN F+ S
Sbjct: 4 LDANVSSEEGFGSV--EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVS 61
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA ADL++ +LV+P A + W G C + TS+DVL TASI LC +++DRY A
Sbjct: 62 LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121
Query: 139 V-TNPLRYGALVTKRCARTAVVL--VWVVSAAVSFAPIMSQWWRVG----ADAEAQRCHS 191
+ PL Y +T R A++L WV+ +SF PIM W +G + +S
Sbjct: 122 ICCQPLVYRNKMTP--LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESP 251
N C F N PY + S V+FY+P L+M+ Y R++V A ++ ES
Sbjct: 180 NSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESR 239
Query: 252 PAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLA 311
P + + + T E +A TL +IMG F LCW PFF+
Sbjct: 240 PQSADQHSTHRMRT---------------------ETKAAKTLCIIMGCFCLCWAPFFVT 278
Query: 312 NVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSAFRRLLCRCGRRLPPE 370
N++ + VPG + A WLGY NS NP +Y + FR AF +LC R
Sbjct: 279 NIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERY--- 334
Query: 371 PCAAARPALFPSGVPAARSS 390
RP++ VP + ++
Sbjct: 335 ----RRPSILGQTVPCSTTT 350
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 171 bits (432), Expect = 1e-42
Identities = 124/380 (32%), Positives = 182/380 (47%), Gaps = 42/380 (11%)
Query: 20 LAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTM-TNVFVTS 78
L N ++ G V E + L+ +L + GNLLV+VA+ W +L+ + TN F+ S
Sbjct: 4 LDANVSSEEGFGSV--EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVS 61
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA ADL++ +LV+P A + W G C + TS+DVL TASI LC +++DRY A
Sbjct: 62 LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121
Query: 139 V-TNPLRYGALVTKRCARTAVVL--VWVVSAAVSFAPIMSQWWRVG----ADAEAQRCHS 191
+ PL Y +T R A++L WV+ +SF PIM W +G + +S
Sbjct: 122 ICCQPLVYRNKMTP--LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESP 251
N C F N PY + S V+FY+P L+M+ Y R++V A ++ ES
Sbjct: 180 NSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESR 239
Query: 252 PAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLA 311
P + + + T E +A TL +IMG F LCW PFF+
Sbjct: 240 PQSADQHSTHRMRT---------------------ETKAAKTLCIIMGCFCLCWAPFFVT 278
Query: 312 NVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSAFRRLLCRCGRRLPPE 370
N++ + VPG + A WLGY NS NP +Y + FR AF +LC R
Sbjct: 279 NIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERY--- 334
Query: 371 PCAAARPALFPSGVPAARSS 390
RP++ VP + ++
Sbjct: 335 ----RRPSILGQTVPCSTTT 350
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 171 bits (432), Expect = 1e-42
Identities = 124/380 (32%), Positives = 182/380 (47%), Gaps = 42/380 (11%)
Query: 20 LAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTM-TNVFVTS 78
L N ++ G V E + L+ +L + GNLLV+VA+ W +L+ + TN F+ S
Sbjct: 4 LDANVSSEEGFGSV--EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVS 61
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA ADL++ +LV+P A + W G C + TS+DVL TASI LC +++DRY A
Sbjct: 62 LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121
Query: 139 V-TNPLRYGALVTKRCARTAVVL--VWVVSAAVSFAPIMSQWWRVG----ADAEAQRCHS 191
+ PL Y +T R A++L WV+ +SF PIM W +G + +S
Sbjct: 122 ICCQPLVYRNKMTP--LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESP 251
N C F N PY + S V+FY+P L+M+ Y R++V A ++ ES
Sbjct: 180 NSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESR 239
Query: 252 PAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLA 311
P + + + T E +A TL +IMG F LCW PFF+
Sbjct: 240 PQSADQHSTHRMRT---------------------ETKAAKTLCIIMGCFCLCWAPFFVT 278
Query: 312 NVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSAFRRLLCRCGRRLPPE 370
N++ + VPG + A WLGY NS NP +Y + FR AF +LC R
Sbjct: 279 NIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERY--- 334
Query: 371 PCAAARPALFPSGVPAARSS 390
RP++ VP + ++
Sbjct: 335 ----RRPSILGQTVPCSTTT 350
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 171 bits (432), Expect = 1e-42
Identities = 124/380 (32%), Positives = 182/380 (47%), Gaps = 42/380 (11%)
Query: 20 LAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTM-TNVFVTS 78
L N ++ G V E + L+ +L + GNLLV+VA+ W +L+ + TN F+ S
Sbjct: 4 LDANVSSEEGFGSV--EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVS 61
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA ADL++ +LV+P A + W G C + TS+DVL TASI LC +++DRY A
Sbjct: 62 LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121
Query: 139 V-TNPLRYGALVTKRCARTAVVL--VWVVSAAVSFAPIMSQWWRVG----ADAEAQRCHS 191
+ PL Y +T R A++L WV+ +SF PIM W +G + +S
Sbjct: 122 ICCQPLVYRNKMTP--LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESP 251
N C F N PY + S V+FY+P L+M+ Y R++V A ++ ES
Sbjct: 180 NSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESR 239
Query: 252 PAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLA 311
P + + + T E +A TL +IMG F LCW PFF+
Sbjct: 240 PQSADQHSTHRMRT---------------------ETKAAKTLCIIMGCFCLCWAPFFVT 278
Query: 312 NVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSAFRRLLCRCGRRLPPE 370
N++ + VPG + A WLGY NS NP +Y + FR AF +LC R
Sbjct: 279 NIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERY--- 334
Query: 371 PCAAARPALFPSGVPAARSS 390
RP++ VP + ++
Sbjct: 335 ----RRPSILGQTVPCSTTT 350
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 171 bits (432), Expect = 1e-42
Identities = 124/380 (32%), Positives = 182/380 (47%), Gaps = 42/380 (11%)
Query: 20 LAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTM-TNVFVTS 78
L N ++ G V E + L+ +L + GNLLV+VA+ W +L+ + TN F+ S
Sbjct: 4 LDANVSSEEGFGSV--EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVS 61
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA ADL++ +LV+P A + W G C + TS+DVL TASI LC +++DRY A
Sbjct: 62 LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121
Query: 139 V-TNPLRYGALVTKRCARTAVVL--VWVVSAAVSFAPIMSQWWRVG----ADAEAQRCHS 191
+ PL Y +T R A++L WV+ +SF PIM W +G + +S
Sbjct: 122 ICCQPLVYRNKMTP--LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESP 251
N C F N PY + S V+FY+P L+M+ Y R++V A ++ ES
Sbjct: 180 NSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESR 239
Query: 252 PAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLA 311
P + + + T E +A TL +IMG F LCW PFF+
Sbjct: 240 PQSADQHSTHRMRT---------------------ETKAAKTLCIIMGCFCLCWAPFFVT 278
Query: 312 NVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSAFRRLLCRCGRRLPPE 370
N++ + VPG + A WLGY NS NP +Y + FR AF +LC R
Sbjct: 279 NIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERY--- 334
Query: 371 PCAAARPALFPSGVPAARSS 390
RP++ VP + ++
Sbjct: 335 ----RRPSILGQTVPCSTTT 350
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 171 bits (432), Expect = 1e-42
Identities = 124/380 (32%), Positives = 182/380 (47%), Gaps = 42/380 (11%)
Query: 20 LAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTM-TNVFVTS 78
L N ++ G V E + L+ +L + GNLLV+VA+ W +L+ + TN F+ S
Sbjct: 4 LDANVSSEEGFGSV--EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVS 61
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA ADL++ +LV+P A + W G C + TS+DVL TASI LC +++DRY A
Sbjct: 62 LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121
Query: 139 V-TNPLRYGALVTKRCARTAVVL--VWVVSAAVSFAPIMSQWWRVG----ADAEAQRCHS 191
+ PL Y +T R A++L WV+ +SF PIM W +G + +S
Sbjct: 122 ICCQPLVYRNKMTP--LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESP 251
N C F N PY + S V+FY+P L+M+ Y R++V A ++ ES
Sbjct: 180 NSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESR 239
Query: 252 PAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLA 311
P + + + T E +A TL +IMG F LCW PFF+
Sbjct: 240 PQSADQHSTHRMRT---------------------ETKAAKTLCIIMGCFCLCWAPFFVT 278
Query: 312 NVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSAFRRLLCRCGRRLPPE 370
N++ + VPG + A WLGY NS NP +Y + FR AF +LC R
Sbjct: 279 NIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERY--- 334
Query: 371 PCAAARPALFPSGVPAARSS 390
RP++ VP + ++
Sbjct: 335 ----RRPSILGQTVPCSTTT 350
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 170 bits (431), Expect = 2e-42
Identities = 139/414 (33%), Positives = 191/414 (46%), Gaps = 81/414 (19%)
Query: 18 PTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVT 77
P + ++GL G A + G LL AVLA GN LV V++A LQT TN F+
Sbjct: 18 PAAGASAGASAGLAGQGAAALVGGVLLIGAVLA---GNSLVCVSVATERALQTPTNSFIV 74
Query: 78 SLAAADLVMGLLVVPPAATLALTGH-WPLGATGCELWTSVDVLCVTASIETLCALAVDRY 136
SLAAADL++ LLV+P + G W L C+ ++DV+ TASI LCA++VDR+
Sbjct: 75 SLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRF 134
Query: 137 LAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCC 196
+AV PLRY R + W++SAAV+ AP++ G + R +P C
Sbjct: 135 VAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVA-APVL-----CGLNDVRGR---DPAVC 185
Query: 197 AFASNMPYVLLSSSVSFYLPLLVMLFVYARVF------VVATRQL---RLLRGELGRFPP 247
+ YV+ SS SF+LP +ML +Y F VA R R R G PP
Sbjct: 186 RL-EDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPP 244
Query: 248 EESPPA----------------------------------------------PSRSLAPA 261
+PPA P+ L P
Sbjct: 245 SPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPD 304
Query: 262 PVGT-CAPPEGV----------PACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFL 310
P G+ CAPP+ V P RR + RE +A+ L +++G F LCW PFF+
Sbjct: 305 PCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFV 364
Query: 311 ANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY-CRSPDFRSAFRRLLCRC 363
++ +AL VP A+ WLGY NSA NP+IY + +FR+ FR+ L C
Sbjct: 365 VHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRAC 418
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 167 bits (424), Expect = 1e-41
Identities = 121/338 (35%), Positives = 173/338 (51%), Gaps = 37/338 (10%)
Query: 48 VLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH-WPLG 106
+LA V GN LV +A+ LQT TN V SLA ADL++ LV+P L +TG W
Sbjct: 40 ILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS 99
Query: 107 ATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYG-ALVTKRCARTAVVL--VWV 163
C+++ ++DV+ TASI LCA+++DRY AV P+ Y C R A+++ VWV
Sbjct: 100 RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWV 159
Query: 164 VSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFV 223
++ AVS P++ + G +P C+ SN +V+ SS VSFYLP V + V
Sbjct: 160 LAFAVS-CPLLFGFNTTG----------DPTVCSI-SNPDFVIYSSVVSFYLPFGVTVLV 207
Query: 224 YARVFVVAT--RQLRLLRGELGR-------FPPEESPPAPSRSLAPAPVGTCAPPE-GVP 273
YAR++VV R+ R+L + + FP + P P+ C G P
Sbjct: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
Query: 274 ACGRRPARL----------LPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLV 323
R L +PLRE +A + +++G F +CWLPFFL +VL V
Sbjct: 268 GFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 327
Query: 324 PGPAFLALNWLGYANSAFNPLIYCR-SPDFRSAFRRLL 360
+ A WLGY NSA NP+IY + +FR AF ++L
Sbjct: 328 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 166 bits (420), Expect = 4e-41
Identities = 128/394 (32%), Positives = 184/394 (46%), Gaps = 56/394 (14%)
Query: 20 LAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTM-TNVFVTS 78
L N ++ G V E + L+ +L + GNLLV+VA+ W +L+ + TN F+ S
Sbjct: 4 LDANVSSEEGFGSV--EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVS 61
Query: 79 LAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
LA ADL++ +LV+P A + W G C + TS+DVL TASI LC +++DRY A
Sbjct: 62 LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121
Query: 139 V-TNPLRYGALVTKRCARTAVVL--VWVVSAAVSFAPIMSQWWRVG-ADAE-------AQ 187
+ PL Y +T R A++L WV+ +SF PIM W +G D E Q
Sbjct: 122 ICCQPLVYRNKMTP--LRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQ 179
Query: 188 RCH----------SNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRL 237
H SN C F N PY + S V+FY+P L+M+ Y R++V A
Sbjct: 180 DFHAIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQ 239
Query: 238 LRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLI 297
++ ES P + + + T E +A TL +I
Sbjct: 240 IQMLQRAGASSESRPQSADQHSTHRMRT---------------------ETKAAKTLCII 278
Query: 298 MGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSAF 356
MG F LCW PFF+ N++ + VPG + A WLGY NS NP +Y + FR AF
Sbjct: 279 MGCFCLCWAPFFVTNIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 337
Query: 357 RRLLCRCGRRLPPEPCAAARPALFPSGVPAARSS 390
+LC R RP++ VP + ++
Sbjct: 338 LIILCCDDERY-------RRPSILGQTVPCSTTT 364
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 162 bits (410), Expect = 5e-40
Identities = 112/369 (30%), Positives = 176/369 (47%), Gaps = 33/369 (8%)
Query: 17 LPTLAPNTANTSGLPGVPWEAALAGAL-------LALAVLATVGGNLLVIVAIAWTPRLQ 69
LP A N + + W+ AL L++ LATV N V+ I T +L
Sbjct: 11 LPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLH 70
Query: 70 TMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLC 129
T N + SLA DL++ +LV+P + +T W G C++W S D+ C TASI LC
Sbjct: 71 TPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLC 130
Query: 130 ALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRC 189
+A+DRY A+T+ L Y T A T + +VW +S +S P+ +WR A+AQ
Sbjct: 131 VIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPL---FWR---QAKAQEE 184
Query: 190 HSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQL-------------- 235
S+ C S + Y + S+ +FY+P ++++ +Y R++ A ++
Sbjct: 185 MSD--CLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTA 242
Query: 236 RLLRGELGR--FPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCT 293
L+ G G S A +P+ + R+ RE +A
Sbjct: 243 HLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKI 302
Query: 294 LGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPA-FLALNWLGYANSAFNPLIY-CRSPD 351
LG+I+G F +CWLPFF+ +++ + S PA F WLGY NS NP+IY + +
Sbjct: 303 LGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEE 362
Query: 352 FRSAFRRLL 360
FR AF++++
Sbjct: 363 FRQAFQKIV 371
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 156 bits (394), Expect = 4e-38
Identities = 101/327 (30%), Positives = 155/327 (47%), Gaps = 24/327 (7%)
Query: 43 LLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH 102
LL V AT NLLV+ I + + V S+A +D+++ LV+P + L+G
Sbjct: 46 LLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGR 105
Query: 103 -WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLV 161
W LG C+LW + DVLC TASI + A+A+DRY ++T + Y K + + L
Sbjct: 106 RWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALT 165
Query: 162 WVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVML 221
W +SA +S AP++ W ++ + C + Y + S+ +FYLPL V+L
Sbjct: 166 WALSAVISLAPLLFGWGETYSEGSEE--------CQVSREPSYAVFSTVGAFYLPLCVVL 217
Query: 222 FVYARV-----FVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACG 276
FVY ++ F V +R+ + ++S P PEG
Sbjct: 218 FVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEG----- 272
Query: 277 RRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGY 336
+E RA +G+++G F LCW+PFFL ++ L +P WLGY
Sbjct: 273 ---DTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD-IPAIWKSIFLWLGY 328
Query: 337 ANSAFNPLIYCR-SPDFRSAFRRLLCR 362
+NS FNPLIY + ++ SAF+ R
Sbjct: 329 SNSFFNPLIYTAFNKNYNSAFKNFFSR 355
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 155 bits (393), Expect = 5e-38
Identities = 124/375 (33%), Positives = 174/375 (46%), Gaps = 78/375 (20%)
Query: 48 VLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH-WPLG 106
+LA V GN LV +A+ LQT TN V SLA ADL++ LV+P L +TG W
Sbjct: 40 ILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS 99
Query: 107 ATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRY-GALVTKRCARTAVVL--VWV 163
C+++ ++DV+ TASI LCA+++DRY AV P+ Y C R A+++ VWV
Sbjct: 100 RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWV 159
Query: 164 VSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFV 223
++ AVS P++ + G +P C+ SN +V+ SS VSFYLP V + V
Sbjct: 160 LAFAVS-CPLLFGFNTTG----------DPTVCSI-SNPDFVIYSSVVSFYLPFGVTVLV 207
Query: 224 YARVFVV---------ATRQLRLLRGELGRFPPEESPPAPS------------------- 255
YAR++VV TRQ FP + P P+
Sbjct: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
Query: 256 ----------------RSLAPAPVGTCAPPEGVPA-------------CGRRPARLLPLR 286
SL+P T AP + G R +PLR
Sbjct: 268 GFQERGGELKREEKTRNSLSP----TIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLR 323
Query: 287 EHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY 346
E +A + +++G F +CWLPFFL +VL V + A WLGY NSA NP+IY
Sbjct: 324 EKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIY 383
Query: 347 CR-SPDFRSAFRRLL 360
+ +FR AF ++L
Sbjct: 384 TTFNIEFRKAFLKIL 398
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.137 0.454
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,592,403
Number of Sequences: 37866
Number of extensions: 888422
Number of successful extensions: 9052
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 645
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 7377
Number of HSP's gapped (non-prelim): 1237
length of query: 408
length of database: 18,247,518
effective HSP length: 105
effective length of query: 303
effective length of database: 14,271,588
effective search space: 4324291164
effective search space used: 4324291164
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.