Search of human proteins with 4557265

Search of human proteins with 4557265

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
         (477 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  970   0.0  
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      389   e-108
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               375   e-104
gi|4503383 dopamine receptor D1 [Homo sapiens]                        228   1e-59
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                226   4e-59
gi|4503391 dopamine receptor D5 [Homo sapiens]                        223   2e-58
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                216   3e-56
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    212   5e-55
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    212   5e-55
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    212   5e-55
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    212   5e-55
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi...   207   2e-53
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]           202   4e-52
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]            202   4e-52
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]         201   1e-51
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]         201   1e-51
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]         201   1e-51
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]         201   1e-51
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]         201   1e-51
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]         201   1e-51
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   199   5e-51
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]        198   8e-51
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   196   4e-50
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   196   4e-50
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    196   4e-50
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   194   1e-49
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]              193   3e-49
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         183   3e-46
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   183   3e-46
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...   181   1e-45

>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  970 bits (2507), Expect = 0.0
 Identities = 477/477 (100%), Positives = 477/477 (100%)

Query: 1   MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG 60
           MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
Sbjct: 1   MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG 60

Query: 61  MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV 120
           MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
Sbjct: 61  MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV 120

Query: 121 WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC 180
           WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
Sbjct: 121 WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC 180

Query: 181 TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM 240
           TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
Sbjct: 181 TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM 240

Query: 241 AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP 300
           AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
Sbjct: 241 AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP 300

Query: 301 LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV 360
           LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
Sbjct: 301 LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV 360

Query: 361 FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP 420
           FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
Sbjct: 361 FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP 420

Query: 421 PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV 477
           PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
Sbjct: 421 PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV 477


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  389 bits (998), Expect = e-108
 Identities = 210/390 (53%), Positives = 259/390 (66%), Gaps = 39/390 (10%)

Query: 35  PASPPASLLPP-ASESPE-PLSQQ----WTAGMGLLMALIVLLIVAGNVLVIVAIAKTPR 88
           P +  A LL P  S +P+  ++QQ    W  GMG++M+LIVL IV GNVLVI AIAK  R
Sbjct: 4   PGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFER 63

Query: 89  LQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIET 148
           LQT+TN FI SLA ADLVMGL VVPFGA  ++   W +G+F+CE WTS+DVLCVTASIET
Sbjct: 64  LQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIET 123

Query: 149 LCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARR 208
           LCVIA+DRY AITSPF+YQSLLT+ +AR ++  VW +S L SFLPI MHW+RA   EA  
Sbjct: 124 LCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAIN 183

Query: 209 CYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGG 268
           CY +  CCDF TN+AYAIASS+VSFYVPL IM FVY RVF+EA++Q++KID  E RF   
Sbjct: 184 CYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF--- 240

Query: 269 PARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGK--RRPSRLVALREQKALKTL 326
                                        +    +GR G   RR S+   L+E KALKTL
Sbjct: 241 ------------------------HVQNLSQVEQDGRTGHGLRRSSKF-CLKEHKALKTL 275

Query: 327 GIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKA 386
           GIIMG FTLCWLPFF+ N+V      L+   +++  NW+GY NS FNP+IYCRSPDFR A
Sbjct: 276 GIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIA 335

Query: 387 FQGLLCCAR---RAARRRHATHGDRPRASG 413
           FQ LLC  R   +A    ++++G+    SG
Sbjct: 336 FQELLCLRRSSLKAYGNGYSSNGNTGEQSG 365


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  375 bits (962), Expect = e-104
 Identities = 215/416 (51%), Positives = 259/416 (62%), Gaps = 30/416 (7%)

Query: 13  PGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGM-GLLMALIVLL 71
           P   SS AP PD        L P +   S LP            W A + G L+AL VL 
Sbjct: 5   PHENSSLAPWPD-----LPTLAPNTANTSGLPGVP---------WEAALAGALLALAVLA 50

Query: 72  IVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFC 131
            V GN+LVIVAIA TPRLQT+TN+F+ SLA+ADLVMGLLVVP  AT+ + G W  G+  C
Sbjct: 51  TVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGC 110

Query: 132 ELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSF 191
           ELWTSVDVLCVTASIETLC +A+DRYLA+T+P RY +L+T+  AR  V  VW +SA VSF
Sbjct: 111 ELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSF 170

Query: 192 LPILMHWWRAESD-EARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFRE 250
            PI+  WWR  +D EA+RC+++P+CC F +N  Y + SS VSFY+PL +M FVY RVF  
Sbjct: 171 APIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVV 230

Query: 251 AQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRR 310
           A +Q++ +     RF      PP+PS S  PAP     PP    A             RR
Sbjct: 231 ATRQLRLLRGELGRF-PPEESPPAPSRSLAPAPVGTCAPPEGVPACG-----------RR 278

Query: 311 PSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF-HRELVPDRLFVFFNWLGYAN 369
           P+RL+ LRE +AL TLG+IMG FTLCWLPFFLANV++A     LVP   F+  NWLGYAN
Sbjct: 279 PARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYAN 338

Query: 370 SAFNPIIYCRSPDFRKAFQGLLC-CARRAARRRHATHGDRPRASGCLARPGPPPSP 424
           SAFNP+IYCRSPDFR AF+ LLC C RR      A        SG  A    P  P
Sbjct: 339 SAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQP 394


>gi|4503383 dopamine receptor D1 [Homo sapiens]
          Length = 446

 Score =  228 bits (580), Expect = 1e-59
 Identities = 129/344 (37%), Positives = 190/344 (55%), Gaps = 37/344 (10%)

Query: 65  MALIVLLIVAGNVLVIVAIAKTPRLQT-LTNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           ++L++L  + GN LV  A+ +   L++ +TN F++SLA +DL++ +LV+P+ A   + G 
Sbjct: 30  LSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGF 89

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVW 183
           W +GSF C +W + D++C TASI  LCVI++DRY AI+SPFRY+  +T   A  L+   W
Sbjct: 90  WPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAW 148

Query: 184 AISALVSFLPILMHWWRAE-----SDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC 238
            +S L+SF+P+ + W +A+        A         CD   +R YAI+SSV+SFY+P+ 
Sbjct: 149 TLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVA 208

Query: 239 IMAFVYLRVFREAQKQVKKIDSCERRFLGGP-ARPPSPSPSPVPAPAPPPGPPRPAAAAA 297
           IM   Y R++R AQKQ+++I + ER  +     +  + +  PV    P            
Sbjct: 209 IMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQP------------ 256

Query: 298 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF------HR 351
                          ++   RE K LKTL +IMGVF  CWLPFF+ N +  F        
Sbjct: 257 -----------ESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQP 305

Query: 352 ELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCAR 395
             +    F  F W G+ANS+ NPIIY  + DFRKAF  LL C R
Sbjct: 306 FCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYR 349


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  226 bits (576), Expect = 4e-59
 Identities = 150/433 (34%), Positives = 224/433 (51%), Gaps = 36/433 (8%)

Query: 2   GAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGM 61
           G GV+  G+ E    S+  P   G+A A   +   +    L+  A             G+
Sbjct: 53  GGGVVGAGSGEDNRSSAGEP---GSAGAGGDVNGTAAVGGLVVSAQG----------VGV 99

Query: 62  GLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVW 121
           G+ +A  +L+ VAGN+LVI+++A    LQT+TN FI++LA ADL++   V+PF AT+ V 
Sbjct: 100 GVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVL 159

Query: 122 GRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCT 181
           G W +G  FC++W +VDVLC TASI +LC I++DRY+ +    +Y +++T  +A  ++  
Sbjct: 160 GFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILAL 219

Query: 182 VWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMA 241
           +W ++ +VS  P+L   W+           D + C       YA+ SSV SFY+P+ ++ 
Sbjct: 220 LWVVALVVSVGPLL--GWKEPVPP------DERFCGITEEAGYAVFSSVCSFYLPMAVIV 271

Query: 242 FVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPL 301
            +Y RV+  A+   + +++  +R  G          S V       G    A  A     
Sbjct: 272 VMYCRVYVVARSTTRSLEAGVKRERG--------KASEVVLRIHCRGAATGADGAHGMRS 323

Query: 302 ANGRAGKRRPS-RLVAL-REQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVP-DRL 358
           A G   +   S RL+   RE+KA KTL I++GVF LCW PFF    + +   +L P + +
Sbjct: 324 AKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGV 383

Query: 359 FVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLLCCARRAARRRH---ATHGDRPRASGC 414
           F    WLGY NS  NP+IY C S +F++AF  LL C  R  RRR      +G   RAS  
Sbjct: 384 FKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTS 443

Query: 415 LARPGPPPSPGAA 427
             R    PS G A
Sbjct: 444 GLRQDCAPSSGDA 456


>gi|4503391 dopamine receptor D5 [Homo sapiens]
          Length = 477

 Score =  223 bits (569), Expect = 2e-58
 Identities = 137/366 (37%), Positives = 203/366 (55%), Gaps = 60/366 (16%)

Query: 64  LMALIVLLIVAGNVLVIVAIAKTPRLQT-LTNLFIMSLASADLVMGLLVVPFGATIVVWG 122
           L+ L+++  + GNVLV  AI ++  L+  +TN+FI+SLA +DL + LLV+P+ A   V G
Sbjct: 46  LLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAG 105

Query: 123 RWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTV 182
            W +G+ FC++W + D++C TASI  LCVI++DRY AI+ PFRY+  +T+  A  +V   
Sbjct: 106 YWPFGA-FCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLA 164

Query: 183 WAISALVSFLPILMHWWRAES------DEARRCYN-------------DPKCCDFVTNRA 223
           W +S L+SF+P+ ++W R ++      D      N             + + CD   NR 
Sbjct: 165 WTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRT 224

Query: 224 YAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAP 283
           YAI+SS++SFY+P+ IM   Y R++R AQ Q+++I S ER      A   + S       
Sbjct: 225 YAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLER------AAEHAQS------- 271

Query: 284 APPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLA 343
                     ++AA AP  + RA  +        +E K LKTL +IMGVF  CWLPFF+ 
Sbjct: 272 --------CRSSAACAPDTSLRASIK--------KETKVLKTLSVIMGVFVCCWLPFFIL 315

Query: 344 NVVKAF---HRE-------LVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCC 393
           N +  F   H E        V +  F  F W G+ANS+ NP+IY  + DF+K F  LL C
Sbjct: 316 NCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGC 375

Query: 394 ARRAAR 399
           +   +R
Sbjct: 376 SHFCSR 381


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  216 bits (551), Expect = 3e-56
 Identities = 131/362 (36%), Positives = 198/362 (54%), Gaps = 33/362 (9%)

Query: 61  MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV 120
           +GL++   +L  + GN+LVI+++A    L+T TN FI++LA ADL++   V+PF A + V
Sbjct: 48  VGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEV 107

Query: 121 WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC 180
            G W  G  FC++W +VDVLC TASI +LC I++DRY+ +    +Y +L+TR +A   + 
Sbjct: 108 LGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALL 167

Query: 181 TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM 240
           +VW +S ++S  P+L   W+  +       ND K C       YA+ SS+ SFY+PL ++
Sbjct: 168 SVWVLSTVISIGPLL--GWKEPAP------NDDKECGVTEEPFYALFSSLGSFYIPLAVI 219

Query: 241 AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP 300
             +Y RV+  A++  K +++       G  +  S S                +       
Sbjct: 220 LVMYCRVYIVAKRTTKNLEA-------GVMKEMSNSKELTLR--------IHSKNFHEDT 264

Query: 301 LANGRAGKRRPSRLVAL------REQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL- 353
           L++ +A    P   +A+      RE+KA KTLGI++G+F LCWLPFF+A  + +    L 
Sbjct: 265 LSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLK 324

Query: 354 VPDRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLLCCARRAARRRHATHGDRPRAS 412
            PD +F    WLGY NS  NPIIY C S +F++AF  +L C  R   RR      R R  
Sbjct: 325 PPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRR--RRRLG 382

Query: 413 GC 414
           GC
Sbjct: 383 GC 384


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  212 bits (540), Expect = 5e-55
 Identities = 128/362 (35%), Positives = 199/362 (54%), Gaps = 26/362 (7%)

Query: 47  SESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLV 106
           ++ P P++      +G+++  ++L  V GN+LVI+++A    L ++T+ +I++LA ADL+
Sbjct: 15  TQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL 74

Query: 107 MGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRY 166
           +   V+PF A   V G W +G  FC +W +VDVLC TASI  LC+I++DRY+ ++ P RY
Sbjct: 75  LTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRY 134

Query: 167 QSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAI 226
            +++T+ R    +  VWA+S ++S  P+    WR  + E      D   C       Y +
Sbjct: 135 PTIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPE------DETICQINEEPGYVL 186

Query: 227 ASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPP 286
            S++ SFY+PL I+  +Y RV+  A+++ + + S       G     S S          
Sbjct: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKS-------GLKTDKSDSEQVTLR---- 235

Query: 287 PGPPRPAAAAATAPLANGRAGKRRPSRLVAL-REQKALKTLGIIMGVFTLCWLPFFLANV 345
               R  A A  + +A+ +       RL+   RE+KA KTLGI++G F LCWLPFFL   
Sbjct: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMP 293

Query: 346 VKAFHRELVP-DRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLL--CCARRAARRR 401
           + +F  +  P + +F    WLGY NS  NPIIY C S +F+KAFQ +L   C  R    +
Sbjct: 294 IGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSK 353

Query: 402 HA 403
           HA
Sbjct: 354 HA 355


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  212 bits (540), Expect = 5e-55
 Identities = 128/362 (35%), Positives = 199/362 (54%), Gaps = 26/362 (7%)

Query: 47  SESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLV 106
           ++ P P++      +G+++  ++L  V GN+LVI+++A    L ++T+ +I++LA ADL+
Sbjct: 15  TQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL 74

Query: 107 MGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRY 166
           +   V+PF A   V G W +G  FC +W +VDVLC TASI  LC+I++DRY+ ++ P RY
Sbjct: 75  LTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRY 134

Query: 167 QSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAI 226
            +++T+ R    +  VWA+S ++S  P+    WR  + E      D   C       Y +
Sbjct: 135 PTIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPE------DETICQINEEPGYVL 186

Query: 227 ASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPP 286
            S++ SFY+PL I+  +Y RV+  A+++ + + S       G     S S          
Sbjct: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKS-------GLKTDKSDSEQVTLR---- 235

Query: 287 PGPPRPAAAAATAPLANGRAGKRRPSRLVAL-REQKALKTLGIIMGVFTLCWLPFFLANV 345
               R  A A  + +A+ +       RL+   RE+KA KTLGI++G F LCWLPFFL   
Sbjct: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMP 293

Query: 346 VKAFHRELVP-DRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLL--CCARRAARRR 401
           + +F  +  P + +F    WLGY NS  NPIIY C S +F+KAFQ +L   C  R    +
Sbjct: 294 IGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSK 353

Query: 402 HA 403
           HA
Sbjct: 354 HA 355


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  212 bits (540), Expect = 5e-55
 Identities = 128/362 (35%), Positives = 199/362 (54%), Gaps = 26/362 (7%)

Query: 47  SESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLV 106
           ++ P P++      +G+++  ++L  V GN+LVI+++A    L ++T+ +I++LA ADL+
Sbjct: 15  TQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL 74

Query: 107 MGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRY 166
           +   V+PF A   V G W +G  FC +W +VDVLC TASI  LC+I++DRY+ ++ P RY
Sbjct: 75  LTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRY 134

Query: 167 QSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAI 226
            +++T+ R    +  VWA+S ++S  P+    WR  + E      D   C       Y +
Sbjct: 135 PTIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPE------DETICQINEEPGYVL 186

Query: 227 ASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPP 286
            S++ SFY+PL I+  +Y RV+  A+++ + + S       G     S S          
Sbjct: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKS-------GLKTDKSDSEQVTLR---- 235

Query: 287 PGPPRPAAAAATAPLANGRAGKRRPSRLVAL-REQKALKTLGIIMGVFTLCWLPFFLANV 345
               R  A A  + +A+ +       RL+   RE+KA KTLGI++G F LCWLPFFL   
Sbjct: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMP 293

Query: 346 VKAFHRELVP-DRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLL--CCARRAARRR 401
           + +F  +  P + +F    WLGY NS  NPIIY C S +F+KAFQ +L   C  R    +
Sbjct: 294 IGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSK 353

Query: 402 HA 403
           HA
Sbjct: 354 HA 355


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  212 bits (540), Expect = 5e-55
 Identities = 128/362 (35%), Positives = 199/362 (54%), Gaps = 26/362 (7%)

Query: 47  SESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLV 106
           ++ P P++      +G+++  ++L  V GN+LVI+++A    L ++T+ +I++LA ADL+
Sbjct: 15  TQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL 74

Query: 107 MGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRY 166
           +   V+PF A   V G W +G  FC +W +VDVLC TASI  LC+I++DRY+ ++ P RY
Sbjct: 75  LTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRY 134

Query: 167 QSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAI 226
            +++T+ R    +  VWA+S ++S  P+    WR  + E      D   C       Y +
Sbjct: 135 PTIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPE------DETICQINEEPGYVL 186

Query: 227 ASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPP 286
            S++ SFY+PL I+  +Y RV+  A+++ + + S       G     S S          
Sbjct: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKS-------GLKTDKSDSEQVTLR---- 235

Query: 287 PGPPRPAAAAATAPLANGRAGKRRPSRLVAL-REQKALKTLGIIMGVFTLCWLPFFLANV 345
               R  A A  + +A+ +       RL+   RE+KA KTLGI++G F LCWLPFFL   
Sbjct: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMP 293

Query: 346 VKAFHRELVP-DRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLL--CCARRAARRR 401
           + +F  +  P + +F    WLGY NS  NPIIY C S +F+KAFQ +L   C  R    +
Sbjct: 294 IGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSK 353

Query: 402 HA 403
           HA
Sbjct: 354 HA 355


>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
           sapiens]
          Length = 440

 Score =  207 bits (526), Expect = 2e-53
 Identities = 141/423 (33%), Positives = 208/423 (49%), Gaps = 40/423 (9%)

Query: 33  LVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTL 92
           +VP   P +   PA  +  P +   +  +   + +++ L  A N L+I  I   P L+  
Sbjct: 1   MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT 60

Query: 93  TNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVI 152
           +N F++SL ++DL++GL+V+P      ++GRW      C LWT+ DV+C +ASI  LC+I
Sbjct: 61  SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI 120

Query: 153 ALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYND 212
           +LDRYL I SP RY+  +T  RA  LV   W+++AL SFLP+L+ W   E   AR     
Sbjct: 121 SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGW--HELGHARPPV-- 176

Query: 213 PKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARP 272
           P  C  + +  + + +S ++F++P   + F Y R+   A+KQ  ++ S            
Sbjct: 177 PGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASL----------- 225

Query: 273 PSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALK---TLGII 329
            +   S        P  PRP   +A +             RL     +KALK   TLGI+
Sbjct: 226 TTGMASQASETLQVPRTPRPGVESADS------------RRLATKHSRKALKASLTLGIL 273

Query: 330 MGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQ 388
           +G+F + WLPFF+AN+V+A   + +   LF    WLGY NS  NPIIY     DF++A  
Sbjct: 274 LGMFFVTWLPFFVANIVQAV-CDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALG 332

Query: 389 GLLCCARRAARRRHATHGDRPRASGCLARPG-------PPPSPGAASDDDDDDVVGATPP 441
             L C R    R+ +      R S    RPG       P P P   SD D D   G +  
Sbjct: 333 RFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLP-PDSDSDSDAGSGGSSG 391

Query: 442 ARL 444
            RL
Sbjct: 392 LRL 394


>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
          Length = 397

 Score =  202 bits (515), Expect = 4e-52
 Identities = 122/344 (35%), Positives = 176/344 (51%), Gaps = 53/344 (15%)

Query: 63  LLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWG 122
           +++A+++L+ VAGNV+V +A+    RL+ LTN FI+SLA  DL++GLLV+PF A   +  
Sbjct: 23  VVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSC 82

Query: 123 RWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTV 182
           +W +G  FC ++TS+DV+  TASI  L +I+LDRY A+  P RY  L+T  R    +  +
Sbjct: 83  KWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI 142

Query: 183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAF 242
           W IS  +SFL I + W     +E  +  +    C    N  Y +   +V+FY+PL IM  
Sbjct: 143 WVISITLSFLSIHLGW--NSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCI 200

Query: 243 VYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLA 302
            Y R+F+ A+ Q K+I+                                 +  AAT    
Sbjct: 201 TYYRIFKVARDQAKRINHIS------------------------------SWKAAT---- 226

Query: 303 NGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFH-RELVPDRLFVF 361
                         +RE KA  TL  +MG F +CW P+F A V +     + + + L   
Sbjct: 227 --------------IREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI 272

Query: 362 FNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCCARRAARRRHAT 404
             WLGYANSA NPI+Y   + DFR  +Q L CC R A R  H T
Sbjct: 273 VLWLGYANSALNPILYAALNRDFRTGYQQLFCC-RLANRNSHKT 315


>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
          Length = 359

 Score =  202 bits (515), Expect = 4e-52
 Identities = 122/344 (35%), Positives = 176/344 (51%), Gaps = 53/344 (15%)

Query: 63  LLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWG 122
           +++A+++L+ VAGNV+V +A+    RL+ LTN FI+SLA  DL++GLLV+PF A   +  
Sbjct: 23  VVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSC 82

Query: 123 RWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTV 182
           +W +G  FC ++TS+DV+  TASI  L +I+LDRY A+  P RY  L+T  R    +  +
Sbjct: 83  KWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI 142

Query: 183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAF 242
           W IS  +SFL I + W     +E  +  +    C    N  Y +   +V+FY+PL IM  
Sbjct: 143 WVISITLSFLSIHLGW--NSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCI 200

Query: 243 VYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLA 302
            Y R+F+ A+ Q K+I+                                 +  AAT    
Sbjct: 201 TYYRIFKVARDQAKRINHIS------------------------------SWKAAT---- 226

Query: 303 NGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFH-RELVPDRLFVF 361
                         +RE KA  TL  +MG F +CW P+F A V +     + + + L   
Sbjct: 227 --------------IREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI 272

Query: 362 FNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCCARRAARRRHAT 404
             WLGYANSA NPI+Y   + DFR  +Q L CC R A R  H T
Sbjct: 273 VLWLGYANSALNPILYAALNRDFRTGYQQLFCC-RLANRNSHKT 315


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score =  201 bits (511), Expect = 1e-51
 Identities = 126/344 (36%), Positives = 181/344 (52%), Gaps = 41/344 (11%)

Query: 65  MALIVLLIVAGNVLVIVAIAKTPRLQTL-TNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           ++ ++L+ + GN+LV+VA+    +L+ + TN FI+SLA ADL++ +LV+PFGA  +V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI-TSPFRYQSLLTRARARGLVCTV 182
           W YG  FC + TS+DVL  TASI  LC I+LDRY AI   P  Y++ +T  R   ++   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 183 WAISALVSFLPILMHWWRAESDE--ARRCYN---DPKCCDFVTNRAYAIASSVVSFYVPL 237
           W I   +SFLPI+  W      +   +R +N   +   C F+ N+ YAI  SVV+FY+P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 238 CIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAA 297
            +M   Y R++  A++   +I   +R      +RP S                       
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS----------------------- 242

Query: 298 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR 357
                   A +    R+    E KA KTL IIMG F LCW PFF+ N+V  F    VP +
Sbjct: 243 --------ADQHSTHRM--RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 358 LFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARR 400
           ++  F WLGY NS  NP +Y   +  FR+AF  +LCC     RR
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score =  201 bits (511), Expect = 1e-51
 Identities = 126/344 (36%), Positives = 181/344 (52%), Gaps = 41/344 (11%)

Query: 65  MALIVLLIVAGNVLVIVAIAKTPRLQTL-TNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           ++ ++L+ + GN+LV+VA+    +L+ + TN FI+SLA ADL++ +LV+PFGA  +V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI-TSPFRYQSLLTRARARGLVCTV 182
           W YG  FC + TS+DVL  TASI  LC I+LDRY AI   P  Y++ +T  R   ++   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 183 WAISALVSFLPILMHWWRAESDE--ARRCYN---DPKCCDFVTNRAYAIASSVVSFYVPL 237
           W I   +SFLPI+  W      +   +R +N   +   C F+ N+ YAI  SVV+FY+P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 238 CIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAA 297
            +M   Y R++  A++   +I   +R      +RP S                       
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS----------------------- 242

Query: 298 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR 357
                   A +    R+    E KA KTL IIMG F LCW PFF+ N+V  F    VP +
Sbjct: 243 --------ADQHSTHRM--RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 358 LFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARR 400
           ++  F WLGY NS  NP +Y   +  FR+AF  +LCC     RR
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score =  201 bits (511), Expect = 1e-51
 Identities = 126/344 (36%), Positives = 181/344 (52%), Gaps = 41/344 (11%)

Query: 65  MALIVLLIVAGNVLVIVAIAKTPRLQTL-TNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           ++ ++L+ + GN+LV+VA+    +L+ + TN FI+SLA ADL++ +LV+PFGA  +V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI-TSPFRYQSLLTRARARGLVCTV 182
           W YG  FC + TS+DVL  TASI  LC I+LDRY AI   P  Y++ +T  R   ++   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 183 WAISALVSFLPILMHWWRAESDE--ARRCYN---DPKCCDFVTNRAYAIASSVVSFYVPL 237
           W I   +SFLPI+  W      +   +R +N   +   C F+ N+ YAI  SVV+FY+P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 238 CIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAA 297
            +M   Y R++  A++   +I   +R      +RP S                       
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS----------------------- 242

Query: 298 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR 357
                   A +    R+    E KA KTL IIMG F LCW PFF+ N+V  F    VP +
Sbjct: 243 --------ADQHSTHRM--RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 358 LFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARR 400
           ++  F WLGY NS  NP +Y   +  FR+AF  +LCC     RR
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
          Length = 387

 Score =  201 bits (511), Expect = 1e-51
 Identities = 126/344 (36%), Positives = 181/344 (52%), Gaps = 41/344 (11%)

Query: 65  MALIVLLIVAGNVLVIVAIAKTPRLQTL-TNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           ++ ++L+ + GN+LV+VA+    +L+ + TN FI+SLA ADL++ +LV+PFGA  +V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI-TSPFRYQSLLTRARARGLVCTV 182
           W YG  FC + TS+DVL  TASI  LC I+LDRY AI   P  Y++ +T  R   ++   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 183 WAISALVSFLPILMHWWRAESDE--ARRCYN---DPKCCDFVTNRAYAIASSVVSFYVPL 237
           W I   +SFLPI+  W      +   +R +N   +   C F+ N+ YAI  SVV+FY+P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 238 CIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAA 297
            +M   Y R++  A++   +I   +R      +RP S                       
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS----------------------- 242

Query: 298 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR 357
                   A +    R+    E KA KTL IIMG F LCW PFF+ N+V  F    VP +
Sbjct: 243 --------ADQHSTHRM--RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 358 LFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARR 400
           ++  F WLGY NS  NP +Y   +  FR+AF  +LCC     RR
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
          Length = 378

 Score =  201 bits (511), Expect = 1e-51
 Identities = 126/344 (36%), Positives = 181/344 (52%), Gaps = 41/344 (11%)

Query: 65  MALIVLLIVAGNVLVIVAIAKTPRLQTL-TNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           ++ ++L+ + GN+LV+VA+    +L+ + TN FI+SLA ADL++ +LV+PFGA  +V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI-TSPFRYQSLLTRARARGLVCTV 182
           W YG  FC + TS+DVL  TASI  LC I+LDRY AI   P  Y++ +T  R   ++   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 183 WAISALVSFLPILMHWWRAESDE--ARRCYN---DPKCCDFVTNRAYAIASSVVSFYVPL 237
           W I   +SFLPI+  W      +   +R +N   +   C F+ N+ YAI  SVV+FY+P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 238 CIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAA 297
            +M   Y R++  A++   +I   +R      +RP S                       
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS----------------------- 242

Query: 298 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR 357
                   A +    R+    E KA KTL IIMG F LCW PFF+ N+V  F    VP +
Sbjct: 243 --------ADQHSTHRM--RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 358 LFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARR 400
           ++  F WLGY NS  NP +Y   +  FR+AF  +LCC     RR
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
          Length = 388

 Score =  201 bits (511), Expect = 1e-51
 Identities = 126/344 (36%), Positives = 181/344 (52%), Gaps = 41/344 (11%)

Query: 65  MALIVLLIVAGNVLVIVAIAKTPRLQTL-TNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           ++ ++L+ + GN+LV+VA+    +L+ + TN FI+SLA ADL++ +LV+PFGA  +V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI-TSPFRYQSLLTRARARGLVCTV 182
           W YG  FC + TS+DVL  TASI  LC I+LDRY AI   P  Y++ +T  R   ++   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 183 WAISALVSFLPILMHWWRAESDE--ARRCYN---DPKCCDFVTNRAYAIASSVVSFYVPL 237
           W I   +SFLPI+  W      +   +R +N   +   C F+ N+ YAI  SVV+FY+P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 238 CIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAA 297
            +M   Y R++  A++   +I   +R      +RP S                       
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS----------------------- 242

Query: 298 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR 357
                   A +    R+    E KA KTL IIMG F LCW PFF+ N+V  F    VP +
Sbjct: 243 --------ADQHSTHRM--RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 358 LFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARR 400
           ++  F WLGY NS  NP +Y   +  FR+AF  +LCC     RR
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  199 bits (506), Expect = 5e-51
 Identities = 133/386 (34%), Positives = 180/386 (46%), Gaps = 64/386 (16%)

Query: 63  LLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWG 122
           LL+  ++   V GN  V+ AIA    LQ + N  I SLA  DL++ +LV+P  A   V  
Sbjct: 41  LLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN 100

Query: 123 RWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTV 182
           +W  G   C+L+ ++DVLC T+SI  LC IALDRY AIT P  Y +  T  RA  L+   
Sbjct: 101 KWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT 160

Query: 183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAF 242
           W I  L+S  P+L   WR   D      +DP  C    +  Y I S+  +FY+PL +M  
Sbjct: 161 WLIGFLISIPPML--GWRTPEDR-----SDPDACTISKDHGYTIYSTFGAFYIPLLLMLV 213

Query: 243 VYLRVFREA----QKQVKKID--SCERRFLGGPARPPSPS-------------------- 276
           +Y R+FR A    +K VKK++    + R    PA  P  S                    
Sbjct: 214 LYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGG 273

Query: 277 --------------------------PSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRR 310
                                      S    P P    P P A A+        A  +R
Sbjct: 274 ALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKR 333

Query: 311 PSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL--VPDRLFVFFNWLGYA 368
             ++   RE+K +KTLGIIMG F LCWLPFF+  +V  F      +P  L    NWLGY+
Sbjct: 334 --KMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYS 391

Query: 369 NSAFNPIIYCR-SPDFRKAFQGLLCC 393
           NS  NP+IY   + DF+ AF+ ++ C
Sbjct: 392 NSLLNPVIYAYFNKDFQNAFKKIIKC 417


>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
          Length = 402

 Score =  198 bits (504), Expect = 8e-51
 Identities = 126/358 (35%), Positives = 179/358 (50%), Gaps = 55/358 (15%)

Query: 65  MALIVLLIVAGNVLVIVAIAKTPRLQTL-TNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           ++ ++L+ + GN+LV+VA+    +L+ + TN FI+SLA ADL++ +LV+PFGA  +V   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI-TSPFRYQSLLTRARARGLVCTV 182
           W YG  FC + TS+DVL  TASI  LC I+LDRY AI   P  Y++ +T  R   ++   
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 183 WAISALVSFLPILMHWWRAESDEARRCYN-------------------DPKCCDFVTNRA 223
           W I   +SFLPI+  W      +  R  N                   +   C F+ N+ 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQNSNSTYCVFMVNKP 205

Query: 224 YAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAP 283
           YAI  SVV+FY+P  +M   Y R++  A++   +I   +R      +RP S         
Sbjct: 206 YAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS--------- 256

Query: 284 APPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLA 343
                                 A +    R+    E KA KTL IIMG F LCW PFF+ 
Sbjct: 257 ----------------------ADQHSTHRM--RTETKAAKTLCIIMGCFCLCWAPFFVT 292

Query: 344 NVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARR 400
           N+V  F    VP +++  F WLGY NS  NP +Y   +  FR+AF  +LCC     RR
Sbjct: 293 NIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 350


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  196 bits (498), Expect = 4e-50
 Identities = 124/352 (35%), Positives = 185/352 (52%), Gaps = 27/352 (7%)

Query: 61  MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPF-GATIV 119
           +G ++ LI LL +AGN LV++++    +L+  +N  I+SLA ADL + + V+PF   T +
Sbjct: 84  IGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDL 143

Query: 120 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV 179
           + G+W +G FFC ++ ++DV+C TASI TLCVI++DRYL IT P  Y           ++
Sbjct: 144 IGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMI 203

Query: 180 CTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCI 239
            +VW +SA ++ LP L  W         +  ND K C    +  Y I S+ V+FY+P+ +
Sbjct: 204 LSVWLLSASIT-LPPLFGW--------AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSV 254

Query: 240 MAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATA 299
           M F+Y ++++ A+K   K      +F G P   P    S +               A  +
Sbjct: 255 MLFMYYQIYKAARKSAAK-----HKFPGFPRVEPD---SVIALNGIVKLQKEVEECANLS 306

Query: 300 PLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF----HRELVP 355
            L        R +  +  REQKA  TLGII+G FT+CWLPFFL +  + F        +P
Sbjct: 307 RLLK----HERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362

Query: 356 DRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARRRHATHG 406
             +   F WLGYANS  NP IY   + D R  ++ LL C  R   R+ +  G
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAG 414


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  196 bits (498), Expect = 4e-50
 Identities = 124/352 (35%), Positives = 185/352 (52%), Gaps = 27/352 (7%)

Query: 61  MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPF-GATIV 119
           +G ++ LI LL +AGN LV++++    +L+  +N  I+SLA ADL + + V+PF   T +
Sbjct: 84  IGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDL 143

Query: 120 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV 179
           + G+W +G FFC ++ ++DV+C TASI TLCVI++DRYL IT P  Y           ++
Sbjct: 144 IGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMI 203

Query: 180 CTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCI 239
            +VW +SA ++ LP L  W         +  ND K C    +  Y I S+ V+FY+P+ +
Sbjct: 204 LSVWLLSASIT-LPPLFGW--------AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSV 254

Query: 240 MAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATA 299
           M F+Y ++++ A+K   K      +F G P   P    S +               A  +
Sbjct: 255 MLFMYYQIYKAARKSAAK-----HKFPGFPRVEPD---SVIALNGIVKLQKEVEECANLS 306

Query: 300 PLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF----HRELVP 355
            L        R +  +  REQKA  TLGII+G FT+CWLPFFL +  + F        +P
Sbjct: 307 RLLK----HERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362

Query: 356 DRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARRRHATHG 406
             +   F WLGYANS  NP IY   + D R  ++ LL C  R   R+ +  G
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAG 414


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  196 bits (498), Expect = 4e-50
 Identities = 124/352 (35%), Positives = 185/352 (52%), Gaps = 27/352 (7%)

Query: 61  MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPF-GATIV 119
           +G ++ LI LL +AGN LV++++    +L+  +N  I+SLA ADL + + V+PF   T +
Sbjct: 84  IGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDL 143

Query: 120 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV 179
           + G+W +G FFC ++ ++DV+C TASI TLCVI++DRYL IT P  Y           ++
Sbjct: 144 IGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMI 203

Query: 180 CTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCI 239
            +VW +SA ++ LP L  W         +  ND K C    +  Y I S+ V+FY+P+ +
Sbjct: 204 LSVWLLSASIT-LPPLFGW--------AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSV 254

Query: 240 MAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATA 299
           M F+Y ++++ A+K   K      +F G P   P    S +               A  +
Sbjct: 255 MLFMYYQIYKAARKSAAK-----HKFPGFPRVEPD---SVIALNGIVKLQKEVEECANLS 306

Query: 300 PLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF----HRELVP 355
            L        R +  +  REQKA  TLGII+G FT+CWLPFFL +  + F        +P
Sbjct: 307 RLLK----HERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362

Query: 356 DRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARRRHATHG 406
             +   F WLGYANS  NP IY   + D R  ++ LL C  R   R+ +  G
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAG 414


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  194 bits (493), Expect = 1e-49
 Identities = 131/390 (33%), Positives = 191/390 (48%), Gaps = 18/390 (4%)

Query: 12  EPGNLSSAAPLPDGAAT-AARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVL 70
           EPG    A P P G+ T   +  + ++P  +         + +S  W   + +L+ALI L
Sbjct: 3   EPG-AQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITL 61

Query: 71  LIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFF 130
                N  VI  + +T +L T  N  I SLA  DL++ +LV+P      V GRW  G   
Sbjct: 62  ATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVV 121

Query: 131 CELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVS 190
           C+ W S D+ C TASI  LCVIALDRY AIT    Y +  T  RA  ++  VW  S  +S
Sbjct: 122 CDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISIS 181

Query: 191 FLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFRE 250
             P    W +A+++E        +C     +  Y + S+V +FY P  ++  +Y R++ E
Sbjct: 182 LPPFF--WRQAKAEE-----EVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVE 234

Query: 251 AQKQVKK--IDSCERRFLGGPARPPSP--SPSPVPAPAPPPGPPRPAAAAATAPLANGRA 306
           A+ ++ K   +   +R         SP  + S     +  P  P  + +         R 
Sbjct: 235 ARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRV 294

Query: 307 GKR--RPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRL--FVFF 362
                   +L+A RE+KA KTLGII+G F +CWLPFF+ ++V    ++     L  F FF
Sbjct: 295 SDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFF 354

Query: 363 NWLGYANSAFNPIIYCRS-PDFRKAFQGLL 391
            WLGY NS  NPIIY  S  DF++AF  L+
Sbjct: 355 TWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384


>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
          Length = 465

 Score =  193 bits (491), Expect = 3e-49
 Identities = 150/464 (32%), Positives = 214/464 (46%), Gaps = 90/464 (19%)

Query: 21  PLPDGAATAARLLVPASPPASL----LPPASESPEPLSQQWTAGMGLLMALIVLLIVAGN 76
           PL +G+      L P +  AS      P       P S Q T  +  L  L++LL V GN
Sbjct: 7   PLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGN 66

Query: 77  VLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTS 136
           VLVI+A+  +  L+   NLF++SLASAD+++  LV+PF     V G W +G  +CE++ +
Sbjct: 67  VLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLA 126

Query: 137 VDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILM 196
           +DVL  T+SI  LC I+LDRY +IT    Y    T  R + ++ TVW ISA++SF P++ 
Sbjct: 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLIS 186

Query: 197 HWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVK 256
              +      +    +P+ C+    + Y I+S + SF+ P  IM  VY+R+++ A+++ +
Sbjct: 187 IEKKGGGGGPQPA--EPR-CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243

Query: 257 KIDS-------------CERRFLG-GPARPPSP-----SPSPV--------PAPA----- 284
              S              ERR  G GP R   P      P P         PAPA     
Sbjct: 244 VPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDT 303

Query: 285 ---------------PPPGPPR--------------------------PAAAAATAPLA- 302
                           PPGP R                          P A     P A 
Sbjct: 304 DALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAG 363

Query: 303 --NGRAGKRRPSRLVAL--REQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRL 358
               R G  + SR      RE++    L +++GVF +CW PFF    + A     VP  L
Sbjct: 364 PGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS-VPRTL 422

Query: 359 FVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLLCCARRAARRR 401
           F FF W GY NS+ NP+IY   + DFR+AF+ +LC   R  R+R
Sbjct: 423 FKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILC---RGDRKR 463


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  183 bits (464), Expect = 3e-46
 Identities = 119/387 (30%), Positives = 189/387 (48%), Gaps = 69/387 (17%)

Query: 64  LMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
           L+ L++ +IV GNVLV +A+++   LQT TN  I+SLA ADL++  LV+P+   + V G 
Sbjct: 40  LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99

Query: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLT-RARARGLVCTV 182
           W++    C+++ ++DV+  TASI  LC I++DRY A+  P  Y +  + + R   ++  V
Sbjct: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159

Query: 183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAF 242
           W +S  +S  P+L     A+ +E             + N A+ + SS+VSFYVP  +   
Sbjct: 160 WVLSFTIS-CPLLFGLNNADQNEC-----------IIANPAFVVYSSIVSFYVPFIVTLL 207

Query: 243 VYLRVFREAQKQVKKIDS------------------------CERRFLGGPARPPSPSPS 278
           VY++++   +++ K++++                         E   L   + P     S
Sbjct: 208 VYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYS 267

Query: 279 PVPA-------PAPPPGPPRPAAAAATAPLANGRA-----------------GKRRPS-- 312
           P+P        P P          +   P  NG A                 GK R S  
Sbjct: 268 PIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLK 327

Query: 313 -----RLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGY 367
                +L   +E+KA + L I++GVF +CWLPFF+ +++       +P  L+  F WLGY
Sbjct: 328 TMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGY 387

Query: 368 ANSAFNPIIYCR-SPDFRKAFQGLLCC 393
            NSA NPIIY   + +FRKAF  +L C
Sbjct: 388 VNSAVNPIIYTTFNIEFRKAFLKILHC 414


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  183 bits (464), Expect = 3e-46
 Identities = 120/356 (33%), Positives = 181/356 (50%), Gaps = 21/356 (5%)

Query: 47  SESPEPLS-QQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADL 105
           SE+ +P + Q     + +++++I L  V  N  V+  I  T +L T  N  I SLA+ DL
Sbjct: 26  SEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDL 85

Query: 106 VMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFR 165
           ++ +LV+P      +   W +G   C++W S D+ C TASI  LCVIALDRY AIT    
Sbjct: 86  LVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALE 145

Query: 166 YQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYA 225
           Y    T   A  ++  VWAIS  +S  P+   W +A++ E         C    +  +Y 
Sbjct: 146 YSKRRTAGHAATMIAIVWAISICISIPPLF--WRQAKAQEEM-----SDCLVNTSQISYT 198

Query: 226 IASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSC-ERRFLGGPARPPSPSPSPVPAPA 284
           I S+  +FY+P  ++  +Y R++R A+ ++    S   +RF        S   S     +
Sbjct: 199 IYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNS 258

Query: 285 PPPGPPRPAAAA------ATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWL 338
                   +A +          LA+    ++R S   A RE+KA K LGII+G F +CWL
Sbjct: 259 SLHEGHSHSAGSPLFFNHVKIKLADSALERKRIS---AARERKATKILGIILGAFIICWL 315

Query: 339 PFFLANVVKAFHRE--LVPDRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLL 391
           PFF+ ++V    R+   +   LF FF WLGY NS  NPIIY   + +FR+AFQ ++
Sbjct: 316 PFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score =  181 bits (459), Expect = 1e-45
 Identities = 119/351 (33%), Positives = 172/351 (49%), Gaps = 24/351 (6%)

Query: 58  TAGMGLLMALIVL--LIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFG 115
           T  M + M L+V+  L    N+ VI+AI  T +L    N  I SLA  DL++ +LV+P  
Sbjct: 20  TEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLS 79

Query: 116 ATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARA 175
              +V  RW+ G F CE+W SVD+ C T SI  LCVIALDRY AIT+   Y    T  RA
Sbjct: 80  IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRA 139

Query: 176 RGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRA-YAIASSVVSFY 234
             ++ TVW IS  +S  P+   +WR+     RR    P  C    +   Y I S++ +FY
Sbjct: 140 ALMILTVWTISIFISMPPL---FWRSH----RRLSPPPSQCTIQHDHVIYTIYSTLGAFY 192

Query: 235 VPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPS-----------PSPVPAP 283
           +PL ++  +Y R++  A+   +K  S   R L   +     S            S     
Sbjct: 193 IPLTLILILYYRIYHAAKSLYQKRGS--SRHLSNRSTDSQNSFASCKLTQTFCVSDFSTS 250

Query: 284 APPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLA 343
            P     +  A+    P  N         ++ + RE+KA + LG+I+G F L WLPFF+ 
Sbjct: 251 DPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIK 310

Query: 344 NVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCC 393
            ++       V   +  F  WLGY NS  NP++Y   + DF+ AF+ L+ C
Sbjct: 311 ELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.137    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,937,926
Number of Sequences: 37866
Number of extensions: 1308810
Number of successful extensions: 45702
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1153
Number of HSP's successfully gapped in prelim test: 718
Number of HSP's that attempted gapping in prelim test: 24448
Number of HSP's gapped (non-prelim): 15689
length of query: 477
length of database: 18,247,518
effective HSP length: 106
effective length of query: 371
effective length of database: 14,233,722
effective search space: 5280710862
effective search space used: 5280710862
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.