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Search of human proteins with 45446740
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45446740 ATP-binding cassette, sub-family A, member 2
isoform a [Homo sapiens]
(2436 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 4883 0.0
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 4838 0.0
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 1514 0.0
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 1360 0.0
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 1258 0.0
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 1018 0.0
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 1018 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 526 e-149
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 514 e-145
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 300 2e-80
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 300 2e-80
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 296 2e-79
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 294 8e-79
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 279 3e-74
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 252 3e-66
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 165 4e-40
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 165 4e-40
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 165 4e-40
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap... 89 4e-17
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 86 4e-16
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 82 5e-15
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 81 1e-14
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 81 1e-14
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 81 1e-14
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 81 1e-14
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 81 1e-14
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 81 1e-14
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s... 80 2e-14
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 79 4e-14
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 78 9e-14
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 4883 bits (12665), Expect = 0.0
Identities = 2436/2436 (100%), Positives = 2436/2436 (100%)
Query: 1 MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA 60
MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA
Sbjct: 1 MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA 60
Query: 61 PLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSE 120
PLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSE
Sbjct: 61 PLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSE 120
Query: 121 LEALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQAL 180
LEALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQAL
Sbjct: 121 LEALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQAL 180
Query: 181 LAARVDPPEVYHLLFGPSSALDSQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTC 240
LAARVDPPEVYHLLFGPSSALDSQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTC
Sbjct: 181 LAARVDPPEVYHLLFGPSSALDSQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTC 240
Query: 241 TPGSGELGRILTVPESQKGALQGYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQL 300
TPGSGELGRILTVPESQKGALQGYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQL
Sbjct: 241 TPGSGELGRILTVPESQKGALQGYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQL 300
Query: 301 GLDAPNGSDSSPQAPPPRRLQALLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPP 360
GLDAPNGSDSSPQAPPPRRLQALLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPP
Sbjct: 301 GLDAPNGSDSSPQAPPPRRLQALLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPP 360
Query: 361 ASGAGGAANGTGAGAVMGPNATAEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGN 420
ASGAGGAANGTGAGAVMGPNATAEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGN
Sbjct: 361 ASGAGGAANGTGAGAVMGPNATAEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGN 420
Query: 421 NRTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETF 480
NRTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETF
Sbjct: 421 NRTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETF 480
Query: 481 AFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPA 540
AFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPA
Sbjct: 481 AFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPA 540
Query: 541 LRQDNFSLPSGMALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQD 600
LRQDNFSLPSGMALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQD
Sbjct: 541 LRQDNFSLPSGMALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQD 600
Query: 601 NVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGF 660
NVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGF
Sbjct: 601 NVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGF 660
Query: 661 VWIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSV 720
VWIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSV
Sbjct: 661 VWIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSV 720
Query: 721 AMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMH 780
AMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMH
Sbjct: 721 AMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMH 780
Query: 781 SHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 840
SHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH
Sbjct: 781 SHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 840
Query: 841 DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTML 900
DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTML
Sbjct: 841 DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTML 900
Query: 901 MVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSV 960
MVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSV
Sbjct: 901 MVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSV 960
Query: 961 MEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQV 1020
MEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQV
Sbjct: 961 MEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQV 1020
Query: 1021 VSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRL 1080
VSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRL
Sbjct: 1021 VSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRL 1080
Query: 1081 TVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVG 1140
TVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVG
Sbjct: 1081 TVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVG 1140
Query: 1141 GSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKL 1200
GSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKL
Sbjct: 1141 GSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKL 1200
Query: 1201 KCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRK 1260
KCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRK
Sbjct: 1201 KCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRK 1260
Query: 1261 HVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFL 1320
HVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFL
Sbjct: 1261 HVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFL 1320
Query: 1321 KVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVG 1380
KVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVG
Sbjct: 1321 KVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVG 1380
Query: 1381 SARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQF 1440
SARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQF
Sbjct: 1381 SARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQF 1440
Query: 1441 HGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQ 1500
HGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQ
Sbjct: 1441 HGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQ 1500
Query: 1501 PRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLS 1560
PRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLS
Sbjct: 1501 PRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLS 1560
Query: 1561 SGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTA 1620
SGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTA
Sbjct: 1561 SGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTA 1620
Query: 1621 GPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVS 1680
GPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVS
Sbjct: 1621 GPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVS 1680
Query: 1681 EYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSM 1740
EYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSM
Sbjct: 1681 EYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSM 1740
Query: 1741 PTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFII 1800
PTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFII
Sbjct: 1741 PTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFII 1800
Query: 1801 VAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILF 1860
VAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILF
Sbjct: 1801 VAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILF 1860
Query: 1861 VFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITAT 1920
VFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITAT
Sbjct: 1861 VFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITAT 1920
Query: 1921 VATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKM 1980
VATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKM
Sbjct: 1921 VATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKM 1980
Query: 1981 KSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQR 2040
KSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQR
Sbjct: 1981 KSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQR 2040
Query: 2041 VLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKM 2100
VLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKM
Sbjct: 2041 VLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKM 2100
Query: 2101 LTGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW 2160
LTGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW
Sbjct: 2101 LTGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW 2160
Query: 2161 KDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPK 2220
KDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPK
Sbjct: 2161 KDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPK 2220
Query: 2221 ARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDG 2280
ARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDG
Sbjct: 2221 ARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDG 2280
Query: 2281 YMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSG 2340
YMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSG
Sbjct: 2281 YMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSG 2340
Query: 2341 VLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTEL 2400
VLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTEL
Sbjct: 2341 VLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTEL 2400
Query: 2401 RALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC 2436
RALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC
Sbjct: 2401 RALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC 2436
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 4838 bits (12549), Expect = 0.0
Identities = 2414/2414 (100%), Positives = 2414/2414 (100%)
Query: 23 WVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSAGILPVMQSLCPDGQRDE 82
WVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSAGILPVMQSLCPDGQRDE
Sbjct: 53 WVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSAGILPVMQSLCPDGQRDE 112
Query: 83 FGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSELEALRQHLEALSAGPGTSGSHL 142
FGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSELEALRQHLEALSAGPGTSGSHL
Sbjct: 113 FGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSELEALRQHLEALSAGPGTSGSHL 172
Query: 143 DRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQALLAARVDPPEVYHLLFGPSSALD 202
DRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQALLAARVDPPEVYHLLFGPSSALD
Sbjct: 173 DRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQALLAARVDPPEVYHLLFGPSSALD 232
Query: 203 SQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTCTPGSGELGRILTVPESQKGALQ 262
SQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTCTPGSGELGRILTVPESQKGALQ
Sbjct: 233 SQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTCTPGSGELGRILTVPESQKGALQ 292
Query: 263 GYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQLGLDAPNGSDSSPQAPPPRRLQA 322
GYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQLGLDAPNGSDSSPQAPPPRRLQA
Sbjct: 293 GYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQLGLDAPNGSDSSPQAPPPRRLQA 352
Query: 323 LLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPPASGAGGAANGTGAGAVMGPNAT 382
LLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPPASGAGGAANGTGAGAVMGPNAT
Sbjct: 353 LLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPPASGAGGAANGTGAGAVMGPNAT 412
Query: 383 AEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSK 442
AEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSK
Sbjct: 413 AEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSK 472
Query: 443 EQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRS 502
EQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRS
Sbjct: 473 EQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRS 532
Query: 503 FLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTID 562
FLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTID
Sbjct: 533 FLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTID 592
Query: 563 NAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHV 622
NAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHV
Sbjct: 593 NAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHV 652
Query: 623 HYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVE 682
HYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVE
Sbjct: 653 HYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVE 712
Query: 683 PGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTM 742
PGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTM
Sbjct: 713 PGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTM 772
Query: 743 GLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCF 802
GLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCF
Sbjct: 773 GLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCF 832
Query: 803 LVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLG 862
LVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLG
Sbjct: 833 LVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLG 892
Query: 863 SKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMY 922
SKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMY
Sbjct: 893 SKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMY 952
Query: 923 GLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEE 982
GLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEE
Sbjct: 953 GLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEE 1012
Query: 983 EPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLF 1042
EPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLF
Sbjct: 1013 EPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLF 1072
Query: 1043 PPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRR 1102
PPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRR
Sbjct: 1073 PPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRR 1132
Query: 1103 EMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAI 1162
EMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAI
Sbjct: 1133 EMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAI 1192
Query: 1163 WDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLV 1222
WDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLV
Sbjct: 1193 WDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLV 1252
Query: 1223 KRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSE 1282
KRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSE
Sbjct: 1253 KRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSE 1312
Query: 1283 AAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKD 1342
AAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKD
Sbjct: 1313 AAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKD 1372
Query: 1343 VLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFD 1402
VLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFD
Sbjct: 1373 VLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFD 1432
Query: 1403 NPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQI 1462
NPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQI
Sbjct: 1433 NPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQI 1492
Query: 1463 LLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSP 1522
LLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSP
Sbjct: 1493 LLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSP 1552
Query: 1523 DASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQ 1582
DASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQ
Sbjct: 1553 DASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQ 1612
Query: 1583 GLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCT 1642
GLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCT
Sbjct: 1613 GLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCT 1672
Query: 1643 CSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGN 1702
CSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGN
Sbjct: 1673 CSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGN 1732
Query: 1703 VLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGN 1762
VLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGN
Sbjct: 1733 VLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGN 1792
Query: 1763 PAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKA 1822
PAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKA
Sbjct: 1793 PAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKA 1852
Query: 1823 KHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLL 1882
KHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLL
Sbjct: 1853 KHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLL 1912
Query: 1883 YGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYL 1942
YGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYL
Sbjct: 1913 YGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYL 1972
Query: 1943 KSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVV 2002
KSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVV
Sbjct: 1973 KSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVV 2032
Query: 2003 GFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKS 2062
GFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKS
Sbjct: 2033 GFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKS 2092
Query: 2063 RKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKE 2122
RKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKE
Sbjct: 2093 RKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKE 2152
Query: 2123 LLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADK 2182
LLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADK
Sbjct: 2153 LLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADK 2212
Query: 2183 PAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLT 2242
PAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLT
Sbjct: 2213 PAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLT 2272
Query: 2243 SHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNR 2302
SHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNR
Sbjct: 2273 SHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNR 2332
Query: 2303 NFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFA 2362
NFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFA
Sbjct: 2333 NFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFA 2392
Query: 2363 KKQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDEGLISFE 2422
KKQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDEGLISFE
Sbjct: 2393 KKQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDEGLISFE 2452
Query: 2423 EERAQLSFNTDTLC 2436
EERAQLSFNTDTLC
Sbjct: 2453 EERAQLSFNTDTLC 2466
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 1514 bits (3920), Expect = 0.0
Identities = 890/2004 (44%), Positives = 1179/2004 (58%), Gaps = 252/2004 (12%)
Query: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWL-- 516
KILY P +V+ + N+TF + +W +S +I +F+E + +R L
Sbjct: 382 KILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLD 441
Query: 517 -------------------QQYVAELRLHPEAL---NLSLDELPPALRQDNFSLPSGMAL 554
Q VA L HPE + N S+ A + N
Sbjct: 442 SRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETN--------- 492
Query: 555 LQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRK 614
Q + TI +FM V+++ + E ++N ++ D +A ++F
Sbjct: 493 -QAIRTIS-------RFMECVNLNKLEPIATEVWLINKSMELL--DERKFWAGIVFTGIT 542
Query: 615 DGS--LPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTG---GRFYFLYGFVWIQDMMER 669
GS LP HV YKIR + E+TN+I+ YW PGP Y GF ++QD++E+
Sbjct: 543 PGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQ 602
Query: 670 AIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVA 729
AII G + + G Y+Q PYPCY D FL V+ MPL M ++W+YSVA+ I+ IV
Sbjct: 603 AIIRVLTGTEK-KTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVY 661
Query: 730 EKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLF 789
EKE RLKE M+ MGL+N++ W +WFI+ + L +S L ILK G +L +S ++++F
Sbjct: 662 EKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVF 721
Query: 790 LAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKC 849
L+V+AV TI+ CFL+S L+S+A LA+ACGGIIYF Y+PY+ + D + K
Sbjct: 722 LSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQ----DYVGFTLKI 777
Query: 850 IASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGI 909
ASL+S AFG G +YFAL+E G+G+QW +SPVE D FNL +V+M++ D +YG+
Sbjct: 778 FASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGV 837
Query: 910 LTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAM 969
+TWYIEAV PG YG+PRPWYFP KSYW G E+ E S P + R+S + C
Sbjct: 838 MTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE---ESDEKSHPGSNQKRIS-----EIC-- 887
Query: 970 ESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGA 1029
MEEEPTHL L V + L KVY+D K+A++ L+LN YE Q+ SFLGHNGA
Sbjct: 888 ----------MEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGA 937
Query: 1030 GKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFY 1089
GKTTTMSILTGLFPPTSG+A I G DIR+EM IR+NLG+CPQHNVLFD LTVEEH+WFY
Sbjct: 938 GKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFY 997
Query: 1090 SRLKSMAQEEIRREMDKMIEDLEL-SNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILD 1148
+RLK ++++ ++ EM++M D+ L S+K S LSGGM+RKLSVA+AFVGGS+ +ILD
Sbjct: 998 ARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILD 1057
Query: 1149 EPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLF 1208
EPTAGVDPY+RR IW+L+LKY+ GRTI+LSTHHMDEAD+LGDRIAIISHGKL C GS LF
Sbjct: 1058 EPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLF 1117
Query: 1209 LKGTYGDGYRLTLVKRPAEPGGP------------QEPGLASSPPGRAPLSSCSELQ--- 1253
LK G GY LTLVK+ E ++ S A L S E
Sbjct: 1118 LKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLT 1177
Query: 1254 -----VSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSF 1308
+S IRKHV+ LV D EL+Y+LP EAAK+GAF LF ++ L L +SS+
Sbjct: 1178 IDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSY 1237
Query: 1309 GLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQ 1368
G+ +TTLEE+FLKV+EE S D + S + A G+
Sbjct: 1238 GISETTLEEIFLKVAEE------SGVDAETSDGTLPARRNRRAFGD-------------- 1277
Query: 1369 SQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRV-GQGS 1427
Q+ L+ + +A +P D D + + E + LS + G+GS
Sbjct: 1278 KQSCLRPFTEDDAA--------------------DPNDSD-IDPESRETDLLSGMDGKGS 1316
Query: 1428 RKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPP 1487
++ G L +QF LL KR ARR+ K F+QI+LPA FVC+A+ +L VP G P
Sbjct: 1317 YQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPS 1376
Query: 1488 LVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKS 1547
L L P Y+ N P D +L++ G G C+ +
Sbjct: 1377 LELQPWMYNEQYTFVSNDAP--------------EDTGTLELLNALTKDPGFGTRCMEGN 1422
Query: 1548 PANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDE 1607
P P +GE A ++ ++ F G N+ PSPA
Sbjct: 1423 PI-----PDTPCQAGEEEWTTAPVPQTI-MDLFQNG----NWTMQNPSPA---------- 1462
Query: 1608 DLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFS---CPSSVGG-HPPQM 1663
C CS+ CP GG PPQ
Sbjct: 1463 ---------------------------------CQCSSDKIKKMLPVCPPGAGGLPPPQR 1489
Query: 1664 RVVTGDILTDITGHNVSEYLLFTSDRF-----------RLHRYGAITFG--NVLKSIPAS 1710
+ T DIL D+TG N+S+YL+ T + RYG + G N P+
Sbjct: 1490 KQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQ 1549
Query: 1711 FGTRAPPMVRK-----------------------IAVRRAAQVFYNNKGYHSMPTYLNSL 1747
A ++K + + +V++NNKG+H++ ++LN +
Sbjct: 1550 EVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVI 1609
Query: 1748 NNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLS-LDYLLQGTDVVIAIFIIVAMSFV 1806
NNAILRANL K + NP+ YGIT NHP+N T LS + + DV+++I +I AMSFV
Sbjct: 1610 NNAILRANLQKGE-NPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFV 1668
Query: 1807 PASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPA 1866
PASFVVFL+ E+ +KAKHLQF+SG P+IYWL+N+VWDM NY+VPAT +II F +
Sbjct: 1669 PASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKS 1728
Query: 1867 YTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLL 1926
Y S TN P + L LLYGWSITP+MYPASF F++PS+AYV L +NLFIGI +VATF+L
Sbjct: 1729 YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVL 1788
Query: 1927 QLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEW 1986
+LF D L +N LKS FLIFP++ LG GL++M N+ + + + G+ ++ SP W
Sbjct: 1789 ELFT-DNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGE-NRFVSPLSW 1846
Query: 1987 DIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVED-DVDVASERQRVLRGD 2045
D+V R L AMAVEGVV FL+T++ QY F RP+ + P+ D D DV ERQR+L G
Sbjct: 1847 DLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGG 1906
Query: 2046 ADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDE 2105
ND+++I+ LTK+Y+ + R AVDR+C+G+ PGECFGLLGVNGAGK+STFKMLTGD
Sbjct: 1907 GQNDILEIKELTKIYRRK---RKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDT 1963
Query: 2106 STTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEAR 2165
+ T G+AF+N +S+L + +V Q++GYCPQ DA+ + LT REH++ + LRG+ K+ +
Sbjct: 1964 TVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGK 2023
Query: 2166 VVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFL 2225
V +WA+ KL L KY +K AG YSGGNKRKLSTA+ALIG P +FLDEPTTGMDPKARRFL
Sbjct: 2024 VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFL 2083
Query: 2226 WNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITV 2285
WN L ++K GRSVVLTSHSMEECEALCTR+AIMVNGR RCLGS+QHLKNRFGDGY I V
Sbjct: 2084 WNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVV 2143
Query: 2286 R-TKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGI 2344
R S+ +K V FF FP ++LKE+H +QYQL S SLA++FS + Q L I
Sbjct: 2144 RIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHI 2203
Query: 2345 EDYSVSQTTLDNVFVNFAKKQSDN 2368
EDYSVSQTTLD VFVNFAK QSD+
Sbjct: 2204 EDYSVSQTTLDQVFVNFAKDQSDD 2227
Score = 202 bits (513), Expect = 4e-51
Identities = 184/705 (26%), Positives = 308/705 (43%), Gaps = 106/705 (15%)
Query: 1785 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
D L+ + +F+ +A + A + +V EK + K + G + I W + ++
Sbjct: 630 DIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISS 689
Query: 1845 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLF----LLYGWSITPIMYPAS----- 1895
++ LV A V+IL + +L Y+ P+ LS+F +L + I+ + A+
Sbjct: 690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAAC 749
Query: 1896 -----FWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFP 1950
F +P YV + ++G T + LL V + F +F
Sbjct: 750 GGIIYFTLYLP---YVLCVAWQDYVGFTLKIFASLLS--------PVAFGFGCEYFALFE 798
Query: 1951 NYNLGHGLMEMAYNEYINEYYAKIG-QFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIM 2009
+G + ++ + G S +D G++ +E V
Sbjct: 799 EQGIG-----VQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAV------FP 847
Query: 2010 CQYNFLRRPQRMPVST-----KPVEDDVDVASERQRVLRGDADNDM------VKIENLTK 2058
QY + RP P + + ++ S ++R+ + + V I+NL K
Sbjct: 848 GQYG-IPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVK 906
Query: 2059 VYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHS 2118
VY+ G +AVD L L G+ LG NGAGKT+T +LTG T G A++ G
Sbjct: 907 VYRD---GMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKD 963
Query: 2119 VLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKD-EARVVKWALEKLELT 2177
+ E+ ++Q+LG CPQ + LFD LT EH+ Y RL+G+S K +A + + AL+ +
Sbjct: 964 IRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPS 1023
Query: 2178 KYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGR 2237
SGG +RKLS A+A +G + LDEPT G+DP +RR +W L+L + GR
Sbjct: 1024 SKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY-RQGR 1082
Query: 2238 SVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQS----- 2292
+++L++H M+E + L R+AI+ +G+L C+GS LKN+ G GY +T+ K +S
Sbjct: 1083 TIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSC 1142
Query: 2293 -------------------------------------VKDVVRFFNRNFPEAMLKERHHT 2315
V + ++ EA L E
Sbjct: 1143 RNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGH 1202
Query: 2316 KVQYQLKSEHI---SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQ 2372
++ Y L E + ++F +++ LGI Y +S+TTL+ +F+ A++ + E
Sbjct: 1203 ELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETS 1262
Query: 2373 E-TEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDE 2416
+ T P + G S LRP + A +P D D + E
Sbjct: 1263 DGTLPARRNRRAFGDKQSCLRPFTEDD------AADPNDSDIDPE 1301
Score = 187 bits (474), Expect = 1e-46
Identities = 155/647 (23%), Positives = 288/647 (44%), Gaps = 80/647 (12%)
Query: 704 IEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSI 763
++ ++ +C++ + + A + ++ E+ + K + G+ ++W++ F+ +
Sbjct: 1653 VDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVV 1712
Query: 764 SVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYF 823
T + I + + L V A+ +++ + ++ L A Y
Sbjct: 1713 PATLVIIIF----ICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYV 1768
Query: 824 LSYVPYMYVAIREEVA--------HDKITAFEKCIASL-MSTTAFGLGSKYFALYEVAGV 874
+ +++ I VA +K+ + S+ + F LG + + +
Sbjct: 1769 VLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAM 1828
Query: 875 GIQWHTFSQ----SPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYF 930
F + SP+ D L + V+ VV+ ++T I+ + PRP
Sbjct: 1829 ADALERFGENRFVSPLSWDLVGRNLFA--MAVEGVVFFLITVLIQY---RFFIRPRPVNA 1883
Query: 931 PLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLV 990
L + +ED+ E +R + G + +
Sbjct: 1884 KLSP-------------------------LNDEDEDVRRERQRILDGGGQND-------I 1911
Query: 991 VCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1050
+ + +LTK+Y+ +K A++++ + + + LG NGAGK++T +LTG T G A
Sbjct: 1912 LEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAF 1971
Query: 1051 IYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIED 1110
+ + I + + E+ +N+G CPQ + + + LT EH+ F++ L+ + ++E+ + + I
Sbjct: 1972 LNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRK 2031
Query: 1111 LELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK-Y 1169
L L SGG KRKLS A+A +GG + LDEPT G+DP ARR +W+ L
Sbjct: 2032 LGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVV 2091
Query: 1170 KPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPG 1229
K GR+++L++H M+E + L R+AI+ +G+ +C GS LK +GDGY T+V R
Sbjct: 2092 KEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGY--TIVVR----- 2144
Query: 1230 GPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAF 1289
+A S P P V F +L L Y LPS + +
Sbjct: 2145 ------IAGSNPDLKP--------VQDFFGLAFPGSVLKEKHRNMLQYQLPSSLS---SL 2187
Query: 1290 ERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADV 1336
R+F L +S LH+ + + TTL++VF+ + +DQS ++ D+
Sbjct: 2188 ARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFA-KDQSDDDHLKDL 2233
Score = 56.6 bits (135), Expect = 3e-07
Identities = 55/192 (28%), Positives = 79/192 (41%), Gaps = 32/192 (16%)
Query: 6 QLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSA 65
QL+LLLWKN+T +RR L E+ PL +F IL+ +R P E F A + SA
Sbjct: 6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA-MPSA 64
Query: 66 GILPVMQSLCPDGQRDEFGFL----------QYANSTVTQLLERLDRVVEEGNLFDPARP 115
G LP +Q + + F + + S V +L R++ L+
Sbjct: 65 GTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLL----LYSQKDT 120
Query: 116 SLGSELEALR--QHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQNLSLP 173
S+ + LR Q ++ S+ +D T S FL NLSLP
Sbjct: 121 SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSG---------------FLYHNLSLP 165
Query: 174 NSTAQALLAARV 185
ST +L A V
Sbjct: 166 KSTVDKMLRADV 177
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 1360 bits (3520), Expect = 0.0
Identities = 795/2002 (39%), Positives = 1144/2002 (57%), Gaps = 235/2002 (11%)
Query: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLR---- 514
KILY P R++ AN TF + +V + W + +I F + +R
Sbjct: 397 KILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLG 456
Query: 515 ------WLQQYVAELRLHPEALNLSLDELPPALRQD---NFSLPSGMALLQQLDTIDNAA 565
+L + + E + EA+ L + P + D NF + + + N
Sbjct: 457 NPTVKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWRDIFNITDRTLRLVN-- 514
Query: 566 CGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKD--GSLPPHVH 623
Q++ + +D F+ + DE + L+ ++N+ +A V+F SLPPHV
Sbjct: 515 ----QYLECLVLDKFESYNDETQLTQRALS-LLEENM-FWAGVVFPDMYPWTSSLPPHVK 568
Query: 624 YKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY---GFVWIQDMMERAIIDTFVGHDV 680
YKIR + EKTN+I+ YW GP F Y GF ++QDM+E+ I + V +
Sbjct: 569 YKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQAEA 628
Query: 681 VEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMK 740
G Y+Q PYPC+ D F+ ++ P+ MV++W+YSV+MT++ IV EKE RLKE +K
Sbjct: 629 -PVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLK 687
Query: 741 TMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMF 800
G++NAV W WF+ F +S+S+ LT + +G++L +S I++LFL ++ ATIM
Sbjct: 688 NQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIML 747
Query: 801 CFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFG 860
CFL+S +SKA LA+AC G+IYF Y+P++ + D++TA K SL+S AFG
Sbjct: 748 CFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQ----DRMTAELKKAVSLLSPVAFG 803
Query: 861 LGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPG 920
G++Y +E G+G+QW SP EGD+F+ LL++ M+++DA VYG+L WY++ V PG
Sbjct: 804 FGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPG 863
Query: 921 MYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGM 980
YG P PWYF LQ+SYWLG T +E+ + E+ E G+
Sbjct: 864 DYGTPLPWYFLLQESYWLGG----------EGCSTREERALEKTEPLTEETEDPEHPEGI 913
Query: 981 E------EEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTT 1034
E P +P VCV L K+++ + A+++L++ YENQ+ +FLGHNGAGKTTT
Sbjct: 914 HDSFFEREHPGWVP-GVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTT 972
Query: 1035 MSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKS 1094
+SILTGL PPTSG+ + G DI T +D +R++LGMCPQHN+LF LTV EH+ FY++LK
Sbjct: 973 LSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKG 1032
Query: 1095 MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGV 1154
+QEE + EM+ M+ED L +KR+ Q LSGGM+RKLSVAIAFVG ++ +ILDEPT+GV
Sbjct: 1033 KSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGV 1092
Query: 1155 DPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYG 1214
DPY+RR+IWDL+LKY+ GRTI++STHHMDEADLLGDRIAII+ G+L C G+PLFLK +G
Sbjct: 1093 DPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFG 1152
Query: 1215 DGYRLTLVKR----PAEPGGPQ------EPGLASSPPGRAPLSSCSEL------QVSQFI 1258
G LTLV++ ++ G + G +++ P + ++ ++ +
Sbjct: 1153 TGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVV 1212
Query: 1259 RKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEV 1318
HV LV EL ++LP++ K A+ LF+ LE +L L LSSFG+ DT LEE+
Sbjct: 1213 LHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEI 1272
Query: 1319 FLKVSEEDQSLENSEADVKESRKDVLPGAE--GPASGEGHAGNLARCSELTQSQASLQSA 1376
FLKV+E+ S ++ R++V P GP G Q+
Sbjct: 1273 FLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAG------------QTPQDSNVC 1320
Query: 1377 SSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLK 1436
S A EG P +P+ G + G L
Sbjct: 1321 SPGAPAAHPEG--------------QPPPEPEC---------------PGPQLNTGTQLV 1351
Query: 1437 VRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYH 1496
++ LLVKRF R+ K +QI+LPA FV +A+ +++ +P G+ P L L P Y
Sbjct: 1352 LQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYG 1411
Query: 1497 NYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPT 1556
++Y + +Q V A +L P
Sbjct: 1412 -----------------QQYTFFSMDEPGSEQFT--------VLADVLLNKPG------- 1439
Query: 1557 LNLSSGESRLLAARFFDSMCL-ESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVS 1615
F + CL E + P N P PS SP +
Sbjct: 1440 ---------------FGNRCLKEGWLPEYPCGNSTP---WKTPSVSP------------N 1469
Query: 1616 LPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGF-SCPSSVGGHPPQMRVVTG-DILTD 1673
+ + WT P RC+ + T CP GG PP R +IL D
Sbjct: 1470 ITQLFQKQKWTQVNPSPSC-----RCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQD 1524
Query: 1674 ITGHNVSEYLLFT---------SDRFRLH--RYGAITFGNVLKSIPAS------------ 1710
+T N+S++L+ T +F ++ RYG I+ G L +P +
Sbjct: 1525 LTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLG 1584
Query: 1711 -------------FGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLP 1757
P ++ + +V++NNKG+H++ ++LN +NAILRA+LP
Sbjct: 1585 RIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLP 1644
Query: 1758 KSKGNPAAYGITVTNHPMNKTSASLS-LDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVA 1816
K + +P YGITV + P+N T LS + L D V+AI +I +MSFVPASFV++L+
Sbjct: 1645 KDR-SPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQ 1703
Query: 1817 EKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAV 1876
E+ K+KHLQF+SG +P YW+ N++WD++NY V A V I F AYTSP N PA+
Sbjct: 1704 ERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPAL 1763
Query: 1877 LSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLK 1936
++L LLYGW++ P+MYPASF F+VPS+AYV L NLFIGI ++ TF+L+LFE+++ L
Sbjct: 1764 VALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLL 1823
Query: 1937 VVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAM 1996
N+ L+ ++FP++ LG GL+++A ++ + + YA+ G+ + +PF WD++ + L AM
Sbjct: 1824 RFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGE-EHSANPFHWDLIGKNLFAM 1882
Query: 1997 AVEGVVGFLLTIMCQYNF-----LRRPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMV 2051
VEGVV FLLT++ Q +F + P + P+ V++D DVA ERQR++ G D++
Sbjct: 1883 VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPI----VDEDDDVAEERQRIITGGNKTDIL 1938
Query: 2052 KIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGE 2111
++ LTK+Y AVDRLC+GVRPGECFGLLGVNGAGKT+TFKMLTGD + T G+
Sbjct: 1939 RLHELTKIYPGTSSP---AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGD 1995
Query: 2112 AFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWAL 2171
A V G S+L + +V Q++GYCPQ DA+ + LT REHL LY RLRG+ ++ +V W++
Sbjct: 1996 ATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSI 2055
Query: 2172 EKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILD 2231
+ L LT YAD AGTYSGGNKRKLSTAIALIG P + LDEPTTGMDP+ARR LWN+I+
Sbjct: 2056 KSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVS 2115
Query: 2232 LIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQ 2291
+I+ GR+VVLTSHSMEECEALCTRLAIMV G RC+G+IQHLK++FGDGY++T++ KS +
Sbjct: 2116 IIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPK 2175
Query: 2292 -----SVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIED 2346
+ V +FF NFP ++ +ERH+ +Q+Q+ S SLA++F + L IE+
Sbjct: 2176 DDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSS--SLARIFQLLLSHKDSLLIEE 2233
Query: 2347 YSVSQTTLDNVFVNFAKKQSDN 2368
YSV+QTTLD VFVNFAK+Q+++
Sbjct: 2234 YSVTQTTLDQVFVNFAKQQTES 2255
Score = 74.3 bits (181), Expect = 1e-12
Identities = 60/204 (29%), Positives = 96/204 (47%), Gaps = 23/204 (11%)
Query: 1 MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA 60
MGF+ Q+QLLLWKN TL++R E+ PL LF +L+ LR P S E F A
Sbjct: 1 MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKA 60
Query: 61 PLTSAGILPVMQSLCPDGQRDEF---------GFLQYANSTVTQLLERLDRVVEEGNLFD 111
+ SAG+LP +Q + + F G + N+++ L R+ R +E +
Sbjct: 61 -MPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSI---LARVYRDFQELLMNA 116
Query: 112 PARPSLG---SELEALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQ 168
P LG +EL L Q ++ L +H +R + + ++ + L FL +
Sbjct: 117 PESQHLGRIWTELHILSQFMDTLR-------THPERIAGRGIRIRDILKDEETLTLFLIK 169
Query: 169 NLSLPNSTAQALLAARVDPPEVYH 192
N+ L +S L+ ++V P + H
Sbjct: 170 NIGLSDSVVYLLINSQVRPEQFAH 193
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 1258 bits (3255), Expect = 0.0
Identities = 793/2015 (39%), Positives = 1123/2015 (55%), Gaps = 235/2015 (11%)
Query: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQ 518
K+L+AP +++ + N TF + + +VW + I +F+ L+ L Q
Sbjct: 294 KLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQ 353
Query: 519 YVAELRLHPEALNLSLDELPPALRQDNFSLP-SGMALLQQLDTIDNAACGWIQFMSK-VS 576
E R P E ALR +F P SG Q G + +++ +S
Sbjct: 354 MQDEGRRQPRPGGRDHME---ALR--SFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLS 408
Query: 577 VDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPP----------HVHYKI 626
+D + P E ++V+ L + +A V+F +D S P HV KI
Sbjct: 409 LDKLEAAPSEAALVSRALQLLAEHRF--WAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKI 466
Query: 627 RQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY---GFVWIQDMMERAIIDTFVGHDVVEP 683
R + +TN+IR +W PGP Y GFV++QD++ERA + G +
Sbjct: 467 RMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANP-RA 525
Query: 684 GSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMG 743
G Y+Q PYPCY D FL V+ +PL + ++W+YSV +T++ +V EKE RL++ M+ MG
Sbjct: 526 GLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMG 585
Query: 744 LNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFL 803
L+ AV W+ WF++ +S L +LK G +L +SH +++LFLA +AVAT+ FL
Sbjct: 586 LSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFL 645
Query: 804 VSVLYSKAKLASACGGIIYFLSYVPYMY-VAIREEVAHDKITAFEKCIASLMSTTAFGLG 862
+S +S+A LA+ACGG+ YF Y+PY+ VA R D++ A + ASL+S AFG G
Sbjct: 646 LSAFFSRANLAAACGGLAYFSLYLPYVLCVAWR-----DRLPAGGRVAASLLSPVAFGFG 700
Query: 863 SKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMY 922
+ AL E G G QWH P D F+L +L++DA +YG+ TWY+EAV PG Y
Sbjct: 701 CESLALLEEQGEGAQWHNVGTRPT-ADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQY 759
Query: 923 GLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEE 982
G+P PW FP ++SYW G R P P++ V EE
Sbjct: 760 GIPEPWNFPFRRSYWCGP-RPPKSPAPCPTPLDPKVLV--------------------EE 798
Query: 983 EPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLF 1042
P L V V L K + + AL LSL+ Y+ + +FLGHNGAGKTTT+SIL+GLF
Sbjct: 799 APPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLF 858
Query: 1043 PPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRR 1102
PP+ GSA I GHD+R+ M IR +LG+CPQ+NVLFD LTV+EH+WFY RLK ++ +
Sbjct: 859 PPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGP 918
Query: 1103 EMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAI 1162
E D++++D+ L +K+ + LSGGM+RKLSVAIAFVGGS+ +ILDEPTAGVDP +RR I
Sbjct: 919 EQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGI 978
Query: 1163 WDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLV 1222
W+L+LKY+ GRT++LSTHH+DEA+LLGDR+A+++ G+L CCGSPLFL+ G GY LTLV
Sbjct: 979 WELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLV 1038
Query: 1223 KR--PAEPGGPQEPGLASSPPGRAPLSSCSE------LQVSQFIRKHVASCLLVSDTSTE 1274
K P + + S R + S+ Q+ ++ V LV + E
Sbjct: 1039 KARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHE 1098
Query: 1275 LSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEA 1334
L +LP A G+F LF+ L+ L L L+ +G+ DT+LEE+FLKV EE A
Sbjct: 1099 LVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEE------CAA 1152
Query: 1335 DVKESRKDVLPGAEGPASGEGHAG-NLARCSELTQSQASLQSASSVGSA-RGDEGAGYTD 1392
D D+ G+ G G AG ++ ++ + +L++ GSA D+G+G
Sbjct: 1153 DT-----DMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSG--- 1204
Query: 1393 VYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCAR 1452
PD V V+ AL+R +Q LL+KRF AR
Sbjct: 1205 --------------PDAVG--RVQGWALTR---------------QQLQALLLKRFLLAR 1233
Query: 1453 RNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEE 1512
R+ + LF+QI V A+ V L++ +PP P+
Sbjct: 1234 RSRRGLFAQI------VLPALFVGLALVFSLIVPPFGHYPA------------------- 1268
Query: 1513 RREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFF 1572
LRLSP Q VS F A G G AR
Sbjct: 1269 -----LRLSPTMYGAQ-VSFF------------SEDAPGDPG-------------RARLL 1297
Query: 1573 DSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLP 1632
+++ E+ + P+ + +P + PA + L + N + P + P S P
Sbjct: 1298 EALLQEAGLEEPPVQHSSHRFSAP---EVPAEVAKVLASGNWT-PESPSPACQCSRPGAR 1353
Query: 1633 RLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVV-TGDILTDITGHNVSEYLLFTSDRFR 1691
RL+ + CP++ GG PP V +G+++ ++TG N+S++L+ T R
Sbjct: 1354 RLLPD--------------CPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLV 1399
Query: 1692 LH-----------RYGAITFGN--------------------VLKSIPASFGTRA----P 1716
RYG + G +L +P R
Sbjct: 1400 RQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLT 1459
Query: 1717 PMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMN 1776
+ + + ++++NNKG+HSM ++N +NAILRA+LP A + IT NHP+N
Sbjct: 1460 AWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHA-HSITTLNHPLN 1518
Query: 1777 KTSASLSLDYLLQGT-DVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPII 1835
T LS L+ + DV+++I ++ AMSFVPASF + L+ E+ T+AKHLQ + G +P +
Sbjct: 1519 LTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTL 1578
Query: 1836 YWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPAS 1895
YWL N++WDM NYLVPA V+I F AY +P N PA+L L LLYGWSITP+MYPAS
Sbjct: 1579 YWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPAS 1638
Query: 1896 FWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLG 1955
F+F VPS+AYV L INLFIGI ++ATF+L+LF D+ L+ V+ LK FLIFP++ LG
Sbjct: 1639 FFFSVPSTAYVVLTCINLFIGINGSMATFVLELFS-DQKLQEVSRILKQVFLIFPHFCLG 1697
Query: 1956 HGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFL 2015
GL++M N+ + + + ++G + +SP W++V + L+AM ++G + L T++ Q+
Sbjct: 1698 RGLIDMVRNQAMADAFERLGD-RQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQ 1756
Query: 2016 RRPQRMPVSTKPV--EDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDR 2073
PQ V + P+ E+D DVA ER+RV++G D++ + NLTKVY+ + R+ AVDR
Sbjct: 1757 LLPQPR-VRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQ---RMPAVDR 1812
Query: 2074 LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYC 2133
LCLG+ PGECFGLLGVNGAGKTSTF+M+TGD + GEA + GHSV +E S+GYC
Sbjct: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYC 1872
Query: 2134 PQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKR 2193
PQ DA+F+ LT REHL+L RLRG+ A+ L +L L+ YAD+PAGTYSGGNKR
Sbjct: 1873 PQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKR 1932
Query: 2194 KLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALC 2253
KL+TA+AL+G PA +FLDEPTTGMDP ARRFLWN +L +++ GRSV+LTSHSMEECEALC
Sbjct: 1933 KLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALC 1992
Query: 2254 TRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERH 2313
+RLAIMVNGR RCLGS QHLK RF G+ +T+R +++S + F FP A L+E H
Sbjct: 1993 SRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARS-QPAAAFVAAEFPGAELREAH 2051
Query: 2314 HTKVQYQL-KSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAK---KQSDNL 2369
++++QL +LA+VF ++ G+ED+SVSQT L+ VF+ F+K K D
Sbjct: 2052 GGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTE 2111
Query: 2370 EQQE----TEPPSALQSPLGCLLSLLRPRSAPTEL 2400
EQ+E +P LQ P L P +A T L
Sbjct: 2112 EQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL 2146
Score = 59.7 bits (143), Expect = 3e-08
Identities = 34/74 (45%), Positives = 41/74 (55%), Gaps = 1/74 (1%)
Query: 1 MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA 60
M F QL LLLWKN +RR P L E+ PL LFFIL+ +R P + E F
Sbjct: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHF-PNK 59
Query: 61 PLTSAGILPVMQSL 74
PL SAG +P +Q L
Sbjct: 60 PLPSAGTVPWLQGL 73
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 1018 bits (2631), Expect = 0.0
Identities = 647/1949 (33%), Positives = 1015/1949 (52%), Gaps = 229/1949 (11%)
Query: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRS---FLEQG--RLQQHL 513
+ILYAP ++ K+N T + + +Q W++ S + L Q LQ L
Sbjct: 490 RILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTL 549
Query: 514 R--WLQQYVA-ELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQ 570
R ++Q +V + L L +DEL LR L + + ++ QL+T+ +
Sbjct: 550 RNPFVQVFVKFSVGLDAVELLKQIDELD-ILR---LKLENNIDIIDQLNTLSSLTVNISS 605
Query: 571 FMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGS-----------LP 619
+ + K + E + Y+ N +F SVIF+ + S LP
Sbjct: 606 CVLYDRIQAAKTIDEMER----EAKRLYKSN-ELFGSVIFKLPSNRSWHRGYDSGNVFLP 660
Query: 620 PHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYG--FVWIQDMMERAIIDTFVG 677
P + Y IR + + T +R W PGP+ +YG F+++QD +ERAII+ G
Sbjct: 661 PVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTG 720
Query: 678 HDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKE 737
+ E VQ PYPC+ +D+FL + + +P+ ++++WV +A ++ +V EK+ RL E
Sbjct: 721 RNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHE 780
Query: 738 VMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVAT 797
MK MG+N+ H+ AW I L +++ L ILK+G +L ++ I++L+ + Y+ +
Sbjct: 781 YMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSV 840
Query: 798 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTT 857
I +L+SV ++ +A+ G +IY +++ P++ + E ++++ K SL+S T
Sbjct: 841 IAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVE----NELSYVLKVFMSLLSPT 896
Query: 858 AFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAV 917
AF S+Y A YE G+G+QW SPV+ D + +++ D+ +Y ++ WY+ V
Sbjct: 897 AFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNV 956
Query: 918 HPGMYGLPRPWYFPLQKSYWLGS-GRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEE 976
PG YG+ PWYFP+ SYW G E + + + + + E +
Sbjct: 957 FPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPE---YMF 1013
Query: 977 TRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMS 1036
+ +E EP L + V + +TK+Y K+A++ L+LN YE + S LG NGAGKTTT+S
Sbjct: 1014 SSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTIS 1071
Query: 1037 ILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLK--S 1094
+LTGLF ++G+ +YG DI+T++ +RKN+G+C QH+VLF LT +EHL Y +K
Sbjct: 1072 MLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH 1131
Query: 1095 MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGV 1154
++++ E+ + ++D L + RH V TLSGGMKRKLS++IA +GGSR +ILDEP+ GV
Sbjct: 1132 WTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGV 1191
Query: 1155 DPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYG 1214
DP +RR+IWD+I K K RTI+LSTHH+DEA++L DRIA + G L+CCGSP +LK +G
Sbjct: 1192 DPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFG 1251
Query: 1215 DGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTE 1274
DGY LTL K+ + P L ++ + C + V+ I+ H+ L D E
Sbjct: 1252 DGYHLTLTKK-------KSPNLNAN-------AVCDTMAVTAMIQSHLPEAYLKEDIGGE 1297
Query: 1275 LSYILPSEAAK-KGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSE 1333
L Y+LP + K GA+ L + L+ + L++ +G+ DTT+EEVFL +++E Q +NS
Sbjct: 1298 LVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQ--KNSA 1355
Query: 1334 ADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDV 1393
++ LTQ + +A+ + +
Sbjct: 1356 MSLE---------------------------HLTQKKIGNSNANGIST------------ 1376
Query: 1394 YGDYRPLFDNPQDPDNVSLQEVE-AEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCAR 1452
PD++S+ + ++ +LDG L +++ +L+KRFH R
Sbjct: 1377 -------------PDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTR 1423
Query: 1453 RNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEE 1512
RN K L +Q++LP FV AM + P + +SPS Y Q YAN
Sbjct: 1424 RNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAF----YANYH 1479
Query: 1513 RREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFF 1572
S + LVS G+
Sbjct: 1480 -----------PSTEALVSAMWDFPGI--------------------------------- 1495
Query: 1573 DSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLP 1632
D+MCL + SD + L+ WN S P +
Sbjct: 1496 DNMCLNT-------------------SDLQCLNKDSLEKWNTSGEPITNFGV-------- 1528
Query: 1633 RLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRL 1692
C+CS CP PP R + ++ ++TG V YL+ T++ F
Sbjct: 1529 --------CSCSENVQ--ECP-KFNYSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQ 1577
Query: 1693 HRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAIL 1752
RYG +FG L T P A R A+V+Y+ +GYHS+P YLNSLNN +L
Sbjct: 1578 KRYGGWSFGLPLTKDLRFDITGVP------ANRTLAKVWYDPEGYHSLPAYLNSLNNFLL 1631
Query: 1753 RANLPKSKGNPAAYGITVTNHP----MNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPA 1808
R N+ SK + A +GI + +HP ++ A++S D+++A+ I++ S A
Sbjct: 1632 RVNM--SKYDAARHGIIMYSHPYPGVQDQEQATIS-----SLIDILVALSILMGYSVTTA 1684
Query: 1809 SFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYT 1868
SFV ++V E TKAK LQ +SG YW+ N+++DM+ YLVP + I+ +F LPA+
Sbjct: 1685 SFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFY 1744
Query: 1869 SPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITA----TVATF 1924
S N AV L LL+G++ MY + F A++ + +NLF GI + +V F
Sbjct: 1745 SENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYF 1804
Query: 1925 LLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPF 1984
L + +D L++++ LK FLIFP + G+GL+E++ + + ++ G + F
Sbjct: 1805 LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYG-VEYPNETF 1863
Query: 1985 EWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLR------RPQRMPVSTKPVEDDVDVASER 2038
E + + VA+ +G + F L ++ + ++ R + +++D DV +ER
Sbjct: 1864 EMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAER 1923
Query: 2039 QRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTF 2098
RV G A+ D+V++ LTK Y+ +I+AV+ + +G+ GECFGLLGVNGAGKT+ F
Sbjct: 1924 LRVESGAAEFDLVQLYCLTKTYQLIH-KKIIAVNNISIGIPAGECFGLLGVNGAGKTTIF 1982
Query: 2099 KMLTGDESTTGGEAFV-NGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRG 2157
KMLTGD + G + N L + +GYCPQ DAL D +T EHL Y R+ G
Sbjct: 1983 KMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHG 2042
Query: 2158 ISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGM 2217
I KD V L +L L + D+ S G KRKLSTA+ALIG P+ + LDEP++GM
Sbjct: 2043 IPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGM 2102
Query: 2218 DPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRF 2277
DPK++R LW +I + ++ SV+LTSHSMEECEALCTRLAIMVNG+ +C+GS+QH+K+RF
Sbjct: 2103 DPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2162
Query: 2278 GDGYMITVRTKSSQ-SVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKME 2336
G G+ + V K+++ +++ + +F +FP+ LK++H + ++Y + +A +F +E
Sbjct: 2163 GRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLE 2222
Query: 2337 QVSGVLGIEDYSVSQTTLDNVFVNFAKKQ 2365
L I ++ VSQTTL+ VF+NFAK Q
Sbjct: 2223 TNKTALNITNFLVSQTTLEEVFINFAKDQ 2251
Score = 200 bits (509), Expect = 1e-50
Identities = 127/332 (38%), Positives = 180/332 (54%), Gaps = 20/332 (6%)
Query: 2051 VKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGG 2110
V + +TK+Y S+ +AVD L L G LLG NGAGKT+T MLTG + G
Sbjct: 1028 VALHGVTKIYGSK-----VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAG 1082
Query: 2111 EAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW--KDEARVVK 2168
FV G + +L V++++G C Q D LF LT +EHL LY ++ W K VK
Sbjct: 1083 TIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVK 1142
Query: 2169 WALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNL 2228
L+ L + K GT SGG KRKLS +IALIG + LDEP+TG+DP +RR +W+
Sbjct: 1143 RTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWD- 1201
Query: 2229 ILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK 2288
++ KT R+++L++H ++E E L R+A + G LRC GS +LK FGDGY +T+ K
Sbjct: 1202 VISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKK 1261
Query: 2289 SSQSVK--------DVVRFFNRNFPEAMLKERHHTKVQYQLK--SEHISLA--QVFSKME 2336
S ++ V + PEA LKE ++ Y L S +S A + ++
Sbjct: 1262 KSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALD 1321
Query: 2337 QVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2368
G L I Y +S TT++ VF+N K+ N
Sbjct: 1322 NGMGDLNIGCYGISDTTVEEVFLNLTKESQKN 1353
Score = 168 bits (426), Expect = 5e-41
Identities = 106/353 (30%), Positives = 186/353 (52%), Gaps = 38/353 (10%)
Query: 996 LTKVYK--DDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATI-- 1051
LTK Y+ K +A+N +S+ + + LG NGAGKTT +LTG P+SG+ I
Sbjct: 1941 LTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN 2000
Query: 1052 ----YGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKM 1107
GH +D +G CPQ + L D +TVEEHL+FY+R+ + +++I+ + K+
Sbjct: 2001 KTGSLGH-----VDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKL 2055
Query: 1108 IEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLIL 1167
+ L L + S G KRKLS A+A +G ++LDEP++G+DP ++R +W +I
Sbjct: 2056 LRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIIS 2115
Query: 1168 KYKPGR-TILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPA 1226
+ + +++L++H M+E + L R+AI+ +GK +C GS +K +G G+ + + +
Sbjct: 2116 EEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKN- 2174
Query: 1227 EPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKK 1286
+ + +++F++ H L + L Y +P A
Sbjct: 2175 --------------------NKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTA--- 2211
Query: 1287 GAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKES 1339
G +F LE + AL++++F + TTLEEVF+ +++ +S E ++ + S
Sbjct: 2212 GGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGS 2264
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 1018 bits (2631), Expect = 0.0
Identities = 647/1949 (33%), Positives = 1015/1949 (52%), Gaps = 229/1949 (11%)
Query: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRS---FLEQG--RLQQHL 513
+ILYAP ++ K+N T + + +Q W++ S + L Q LQ L
Sbjct: 808 RILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTL 867
Query: 514 R--WLQQYVA-ELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQ 570
R ++Q +V + L L +DEL LR L + + ++ QL+T+ +
Sbjct: 868 RNPFVQVFVKFSVGLDAVELLKQIDELD-ILR---LKLENNIDIIDQLNTLSSLTVNISS 923
Query: 571 FMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGS-----------LP 619
+ + K + E + Y+ N +F SVIF+ + S LP
Sbjct: 924 CVLYDRIQAAKTIDEMER----EAKRLYKSN-ELFGSVIFKLPSNRSWHRGYDSGNVFLP 978
Query: 620 PHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYG--FVWIQDMMERAIIDTFVG 677
P + Y IR + + T +R W PGP+ +YG F+++QD +ERAII+ G
Sbjct: 979 PVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTG 1038
Query: 678 HDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKE 737
+ E VQ PYPC+ +D+FL + + +P+ ++++WV +A ++ +V EK+ RL E
Sbjct: 1039 RNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHE 1098
Query: 738 VMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVAT 797
MK MG+N+ H+ AW I L +++ L ILK+G +L ++ I++L+ + Y+ +
Sbjct: 1099 YMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSV 1158
Query: 798 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTT 857
I +L+SV ++ +A+ G +IY +++ P++ + E ++++ K SL+S T
Sbjct: 1159 IAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVE----NELSYVLKVFMSLLSPT 1214
Query: 858 AFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAV 917
AF S+Y A YE G+G+QW SPV+ D + +++ D+ +Y ++ WY+ V
Sbjct: 1215 AFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNV 1274
Query: 918 HPGMYGLPRPWYFPLQKSYWLGS-GRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEE 976
PG YG+ PWYFP+ SYW G E + + + + + E +
Sbjct: 1275 FPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPE---YMF 1331
Query: 977 TRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMS 1036
+ +E EP L + V + +TK+Y K+A++ L+LN YE + S LG NGAGKTTT+S
Sbjct: 1332 SSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTIS 1389
Query: 1037 ILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLK--S 1094
+LTGLF ++G+ +YG DI+T++ +RKN+G+C QH+VLF LT +EHL Y +K
Sbjct: 1390 MLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH 1449
Query: 1095 MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGV 1154
++++ E+ + ++D L + RH V TLSGGMKRKLS++IA +GGSR +ILDEP+ GV
Sbjct: 1450 WTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGV 1509
Query: 1155 DPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYG 1214
DP +RR+IWD+I K K RTI+LSTHH+DEA++L DRIA + G L+CCGSP +LK +G
Sbjct: 1510 DPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFG 1569
Query: 1215 DGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTE 1274
DGY LTL K+ + P L ++ + C + V+ I+ H+ L D E
Sbjct: 1570 DGYHLTLTKK-------KSPNLNAN-------AVCDTMAVTAMIQSHLPEAYLKEDIGGE 1615
Query: 1275 LSYILPSEAAK-KGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSE 1333
L Y+LP + K GA+ L + L+ + L++ +G+ DTT+EEVFL +++E Q +NS
Sbjct: 1616 LVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQ--KNSA 1673
Query: 1334 ADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDV 1393
++ LTQ + +A+ + +
Sbjct: 1674 MSLE---------------------------HLTQKKIGNSNANGIST------------ 1694
Query: 1394 YGDYRPLFDNPQDPDNVSLQEVE-AEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCAR 1452
PD++S+ + ++ +LDG L +++ +L+KRFH R
Sbjct: 1695 -------------PDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTR 1741
Query: 1453 RNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEE 1512
RN K L +Q++LP FV AM + P + +SPS Y Q YAN
Sbjct: 1742 RNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAF----YANYH 1797
Query: 1513 RREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFF 1572
S + LVS G+
Sbjct: 1798 -----------PSTEALVSAMWDFPGI--------------------------------- 1813
Query: 1573 DSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLP 1632
D+MCL + SD + L+ WN S P +
Sbjct: 1814 DNMCLNT-------------------SDLQCLNKDSLEKWNTSGEPITNFGV-------- 1846
Query: 1633 RLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRL 1692
C+CS CP PP R + ++ ++TG V YL+ T++ F
Sbjct: 1847 --------CSCSENVQ--ECP-KFNYSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQ 1895
Query: 1693 HRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAIL 1752
RYG +FG L T P A R A+V+Y+ +GYHS+P YLNSLNN +L
Sbjct: 1896 KRYGGWSFGLPLTKDLRFDITGVP------ANRTLAKVWYDPEGYHSLPAYLNSLNNFLL 1949
Query: 1753 RANLPKSKGNPAAYGITVTNHP----MNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPA 1808
R N+ SK + A +GI + +HP ++ A++S D+++A+ I++ S A
Sbjct: 1950 RVNM--SKYDAARHGIIMYSHPYPGVQDQEQATIS-----SLIDILVALSILMGYSVTTA 2002
Query: 1809 SFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYT 1868
SFV ++V E TKAK LQ +SG YW+ N+++DM+ YLVP + I+ +F LPA+
Sbjct: 2003 SFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFY 2062
Query: 1869 SPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITA----TVATF 1924
S N AV L LL+G++ MY + F A++ + +NLF GI + +V F
Sbjct: 2063 SENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYF 2122
Query: 1925 LLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPF 1984
L + +D L++++ LK FLIFP + G+GL+E++ + + ++ G + F
Sbjct: 2123 LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYG-VEYPNETF 2181
Query: 1985 EWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLR------RPQRMPVSTKPVEDDVDVASER 2038
E + + VA+ +G + F L ++ + ++ R + +++D DV +ER
Sbjct: 2182 EMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAER 2241
Query: 2039 QRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTF 2098
RV G A+ D+V++ LTK Y+ +I+AV+ + +G+ GECFGLLGVNGAGKT+ F
Sbjct: 2242 LRVESGAAEFDLVQLYCLTKTYQLIH-KKIIAVNNISIGIPAGECFGLLGVNGAGKTTIF 2300
Query: 2099 KMLTGDESTTGGEAFV-NGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRG 2157
KMLTGD + G + N L + +GYCPQ DAL D +T EHL Y R+ G
Sbjct: 2301 KMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHG 2360
Query: 2158 ISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGM 2217
I KD V L +L L + D+ S G KRKLSTA+ALIG P+ + LDEP++GM
Sbjct: 2361 IPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGM 2420
Query: 2218 DPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRF 2277
DPK++R LW +I + ++ SV+LTSHSMEECEALCTRLAIMVNG+ +C+GS+QH+K+RF
Sbjct: 2421 DPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2480
Query: 2278 GDGYMITVRTKSSQ-SVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKME 2336
G G+ + V K+++ +++ + +F +FP+ LK++H + ++Y + +A +F +E
Sbjct: 2481 GRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLE 2540
Query: 2337 QVSGVLGIEDYSVSQTTLDNVFVNFAKKQ 2365
L I ++ VSQTTL+ VF+NFAK Q
Sbjct: 2541 TNKTALNITNFLVSQTTLEEVFINFAKDQ 2569
Score = 200 bits (509), Expect = 1e-50
Identities = 127/332 (38%), Positives = 180/332 (54%), Gaps = 20/332 (6%)
Query: 2051 VKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGG 2110
V + +TK+Y S+ +AVD L L G LLG NGAGKT+T MLTG + G
Sbjct: 1346 VALHGVTKIYGSK-----VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAG 1400
Query: 2111 EAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW--KDEARVVK 2168
FV G + +L V++++G C Q D LF LT +EHL LY ++ W K VK
Sbjct: 1401 TIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVK 1460
Query: 2169 WALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNL 2228
L+ L + K GT SGG KRKLS +IALIG + LDEP+TG+DP +RR +W+
Sbjct: 1461 RTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWD- 1519
Query: 2229 ILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK 2288
++ KT R+++L++H ++E E L R+A + G LRC GS +LK FGDGY +T+ K
Sbjct: 1520 VISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKK 1579
Query: 2289 SSQSVK--------DVVRFFNRNFPEAMLKERHHTKVQYQLK--SEHISLA--QVFSKME 2336
S ++ V + PEA LKE ++ Y L S +S A + ++
Sbjct: 1580 KSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALD 1639
Query: 2337 QVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2368
G L I Y +S TT++ VF+N K+ N
Sbjct: 1640 NGMGDLNIGCYGISDTTVEEVFLNLTKESQKN 1671
Score = 168 bits (426), Expect = 5e-41
Identities = 106/353 (30%), Positives = 186/353 (52%), Gaps = 38/353 (10%)
Query: 996 LTKVYK--DDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATI-- 1051
LTK Y+ K +A+N +S+ + + LG NGAGKTT +LTG P+SG+ I
Sbjct: 2259 LTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN 2318
Query: 1052 ----YGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKM 1107
GH +D +G CPQ + L D +TVEEHL+FY+R+ + +++I+ + K+
Sbjct: 2319 KTGSLGH-----VDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKL 2373
Query: 1108 IEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLIL 1167
+ L L + S G KRKLS A+A +G ++LDEP++G+DP ++R +W +I
Sbjct: 2374 LRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIIS 2433
Query: 1168 KYKPGR-TILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPA 1226
+ + +++L++H M+E + L R+AI+ +GK +C GS +K +G G+ + + +
Sbjct: 2434 EEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKN- 2492
Query: 1227 EPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKK 1286
+ + +++F++ H L + L Y +P A
Sbjct: 2493 --------------------NKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTA--- 2529
Query: 1287 GAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKES 1339
G +F LE + AL++++F + TTLEEVF+ +++ +S E ++ + S
Sbjct: 2530 GGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGS 2582
Score = 45.4 bits (106), Expect = 7e-04
Identities = 28/74 (37%), Positives = 40/74 (54%), Gaps = 3/74 (4%)
Query: 5 HQLQLLLWKN-VTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLT 63
HQLQ+L+WKN + +KR+ W L I P+++F IL R K P + K + L
Sbjct: 6 HQLQILVWKNWLGVKRQPLWTLVL-ILWPVIIFIILAITRTKFPP-TAKPTCYLAPRNLP 63
Query: 64 SAGILPVMQSLCPD 77
S G P +Q+L D
Sbjct: 64 STGFFPFLQTLLCD 77
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 526 bits (1356), Expect = e-149
Identities = 346/963 (35%), Positives = 516/963 (53%), Gaps = 143/963 (14%)
Query: 581 KGFPDEESIVNYTLNQAYQDNVT--VFASVIFQTRKDGS---LPPHVHYKIR-------- 627
+GFP E+ +Y DN + V A+V+F+ + S LP V Y +R
Sbjct: 108 RGFPSEKDFEDYIR----YDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNY 163
Query: 628 ---QNSSFTEK------TNEIRRAYWRPGPNT------GGRFYFLYGFVWIQDMMERAII 672
Q SF K T + + PGP G Y GF+ +Q ++RAI+
Sbjct: 164 MWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIM 223
Query: 673 DTFVGHDVVEPGSY------VQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQH 726
+ D + ++ FPYP + D FL I++ +PL +++S+ Y+ +
Sbjct: 224 EYHA--DAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARA 281
Query: 727 IVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG-----QVLMHS 781
+V EKE RLKE M+ MGL++ +HW AWF+ F+ L I+ + +T + VL S
Sbjct: 282 VVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRS 341
Query: 782 HVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHD 841
++ FL +A++TI F F+VS +SKA +A+A GG +YF +Y+PY +VA R ++
Sbjct: 342 DPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPR----YN 397
Query: 842 KITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM 901
+T +K + L+S A +G++ +E G+GIQW DDF + ML+
Sbjct: 398 WMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLL 457
Query: 902 VDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVM 961
+D+V+YG++TWY+EAV PG +G+P+PWYF + SYW G R A +
Sbjct: 458 LDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGK-------------- 503
Query: 962 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKK--LALNKLSLNLYENQ 1019
EE+ + ++ R E E EP L + + L+KV++ K A+ L+LNLYE Q
Sbjct: 504 EEEDSDPEKALRNEY---FEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQ 560
Query: 1020 VVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1079
+ LGHNGAGKTTT+S+LTGLFPPTSG A I G++I +M +IRK+LG+CPQH++LFD
Sbjct: 561 ITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDN 620
Query: 1080 LTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFV 1139
LTV EHL+FY++LK +++++ E+ +M+ + L +K +S + LSGGM+RKLS+ IA +
Sbjct: 621 LTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALI 680
Query: 1140 GGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGK 1199
GS+ +ILDEPT+G+D +RRAIWDL+ + K RTI+L+TH MDEADLLGDRIAI++ G+
Sbjct: 681 AGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGE 740
Query: 1200 LKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIR 1259
L+CCGS LFLK YG GY +TLVK P C+ +SQ +
Sbjct: 741 LQCCGSSLFLKQKYGAGYHMTLVKEP----------------------HCNPEDISQLVH 778
Query: 1260 KHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVF 1319
HV + L S ELS+ILP E+ + FE LF LE+ L ++SFG TT+EEVF
Sbjct: 779 HHVPNATLESSAGAELSFILPRESTHR--FEGLFAKLEKKQKELGIASFGASITTMEEVF 836
Query: 1320 LKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSV 1379
L+V + L +S D++ + LP + E A + A S L
Sbjct: 837 LRVGK----LVDSSMDIQAIQ---LPALQ--YQHERRASDWAVDSNL------------C 875
Query: 1380 GSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGW-LKVR 1438
G+ +G G +L E E A+ KL+ G L +
Sbjct: 876 GAMDPSDGIG---------------------ALIEEERTAV--------KLNTGLALHCQ 906
Query: 1439 QFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNY 1498
QF + +K+ + R K + +Q+L+P V +A+ E+ D P L L+ +Y
Sbjct: 907 QFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRT 966
Query: 1499 TQP 1501
P
Sbjct: 967 VVP 969
Score = 463 bits (1191), Expect = e-129
Identities = 270/689 (39%), Positives = 401/689 (58%), Gaps = 53/689 (7%)
Query: 1720 RKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTS 1779
R + R +NN+ YHS T L ++N + K P A I V+N P +++
Sbjct: 1030 RDVGERTVVNALFNNQAYHSPATALAVVDNLLF-----KLLCGPHA-SIVVSNFPQPRSA 1083
Query: 1780 ASLSLDYLLQGTDVV-IAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWL 1838
+ D +G IA+ ++ AM+F+ ++F + V+E++ +AKH+QFVSG + +WL
Sbjct: 1084 LQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWL 1143
Query: 1839 ANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWF 1898
+ +WD++++L+P+ +++ FD+ A+T + L L LLYGW+I P+MY +F+F
Sbjct: 1144 SALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFF 1203
Query: 1899 EVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKV--VNSYLKSCFLIFPNYNLGH 1956
++AY L + N+ GI ATFL+ +K+ ++ L FL+ PN+ LG
Sbjct: 1204 LGAATAYTRLTIFNILSGI----ATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGM 1259
Query: 1957 GLMEMAYNEYINEY---------YAKIGQFDKMKSPFEWDI--VTRGLVAMAVEGVVGFL 2005
+ N Y Y K ++ + W V R + +MA G +
Sbjct: 1260 AVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLI 1319
Query: 2006 LTIMCQYNFLRRPQ-----------------RMPVSTKPVEDDVDVASERQRVLRGDADN 2048
L + + N L+R + RMPV + +D DVA ER R+L D+
Sbjct: 1320 LLFLIETNLLQRLRGILCALRRRRTLTELYTRMPV----LPEDQDVADERTRILAPSPDS 1375
Query: 2049 DM---VKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDE 2105
+ + I+ L+KVY+ R +LAVDRL L V+ GECFGLLG NGAGKT+TFKMLTG+E
Sbjct: 1376 LLHTPLIIKELSKVYEQRV--PLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEE 1433
Query: 2106 STTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEAR 2165
S T G+AFV GH + ++ +V+Q +GYCPQ DAL D +T RE L +Y RLRGI +
Sbjct: 1434 SLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGA 1493
Query: 2166 VVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFL 2225
V+ L L L +A+K TYSGGNKRKLST IALIG PA IFLDEP+TGMDP ARR L
Sbjct: 1494 CVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLL 1553
Query: 2226 WNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITV 2285
W+ + ++G+++++TSHSMEECEALCTRLAIMV G+ +CLGS QHLK++FG GY +
Sbjct: 1554 WDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRA 1613
Query: 2286 RTKS---SQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVL 2342
+ +S +++++ F + FP ++L++ H V Y L +S A+VF +E+
Sbjct: 1614 KVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKY 1673
Query: 2343 GIEDYSVSQTTLDNVFVNFAKKQSDNLEQ 2371
G++DYSVSQ +L+ VF++FA Q E+
Sbjct: 1674 GVDDYSVSQISLEQVFLSFAHLQPPTAEE 1702
Score = 214 bits (545), Expect = 8e-55
Identities = 175/621 (28%), Positives = 296/621 (47%), Gaps = 44/621 (7%)
Query: 1785 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
D L + + ++++ ++ + +V EK + K + G + ++W A ++
Sbjct: 253 DPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLF 312
Query: 1845 MLNYLVPATCCVIILFVFDLP--AYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPS 1902
L L+ A+ ++ V P A S ++ VL+ L + S + S +F +
Sbjct: 313 FLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKAN 372
Query: 1903 SAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMA 1962
A F + F T++ F + + S K C + N + G
Sbjct: 373 MAAAFGGFLYFF--------TYIPYFFVAPRYNWMTLSQ-KLCSCLLSNVAMAMGA---- 419
Query: 1963 YNEYINEYYAK-IG-QFDKMKSPFE---------------WDIVTRGLVAMAVEGVVGFL 2005
+ I ++ AK +G Q+ + SP D V GLV +E V
Sbjct: 420 --QLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQ 477
Query: 2006 LTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGD----ADNDMV---KIENLTK 2058
+ + F P + V + S+ ++ LR + D+V KI++L+K
Sbjct: 478 FGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSK 537
Query: 2059 VYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHS 2118
V++ R AV L L + G+ LLG NGAGKT+T MLTG T G A+++G+
Sbjct: 538 VFRVGNKDRA-AVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYE 596
Query: 2119 VLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTK 2178
+ ++++Q+++SLG CPQ D LFD LT EHL Y +L+G+S + VK L + L
Sbjct: 597 ISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLED 656
Query: 2179 YADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRS 2238
+ + SGG +RKLS IALI + LDEPT+GMD +RR +W+L L K+ R+
Sbjct: 657 KWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDL-LQRQKSDRT 715
Query: 2239 VVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVR 2298
+VLT+H M+E + L R+AIM G L+C GS LK ++G GY +T+ + + +D+ +
Sbjct: 716 IVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQ 775
Query: 2299 FFNRNFPEAMLKERHHTKVQYQLKSEHISLAQ-VFSKMEQVSGVLGIEDYSVSQTTLDNV 2357
+ + P A L+ ++ + L E + +F+K+E+ LGI + S TT++ V
Sbjct: 776 LVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEV 835
Query: 2358 FVNFAKKQSDNLEQQETEPPS 2378
F+ K +++ Q + P+
Sbjct: 836 FLRVGKLVDSSMDIQAIQLPA 856
Score = 189 bits (479), Expect = 4e-47
Identities = 120/366 (32%), Positives = 193/366 (52%), Gaps = 28/366 (7%)
Query: 957 RLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKL-ALNKLSLNL 1015
R+ V+ EDQ A E R + H PL++ +L+KVY+ L A+++LSL +
Sbjct: 1351 RMPVLPEDQDVADERTRI--LAPSPDSLLHTPLII--KELSKVYEQRVPLLAVDRLSLAV 1406
Query: 1016 YENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNV 1075
+ + LG NGAGKTTT +LTG TSG A + GH I +++ ++R+ +G CPQ +
Sbjct: 1407 QKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDA 1466
Query: 1076 LFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVA 1135
L D +T E L Y+RL+ + + I ++ + L L + LV+T SGG KRKLS
Sbjct: 1467 LLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTG 1526
Query: 1136 IAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYK-PGRTILLSTHHMDEADLLGDRIAI 1194
IA +G I LDEP+ G+DP ARR +WD + + + G+ I++++H M+E + L R+AI
Sbjct: 1527 IALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAI 1586
Query: 1195 ISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQV 1254
+ G+ KC GSP LK +G GY L + + G QE + +
Sbjct: 1587 MVQGQFKCLGSPQHLKSKFGSGYSL---RAKVQSEGQQE----------------ALEEF 1627
Query: 1255 SQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTT 1314
F+ +L + + Y LP + ++ ++F LE++ + + + + +
Sbjct: 1628 KAFVDLTFPGSVLEDEHQGMVHYHLP---GRDLSWAKVFGILEKAKEKYGVDDYSVSQIS 1684
Query: 1315 LEEVFL 1320
LE+VFL
Sbjct: 1685 LEQVFL 1690
Score = 54.3 bits (129), Expect = 1e-06
Identities = 37/102 (36%), Positives = 52/102 (50%), Gaps = 6/102 (5%)
Query: 1 MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA 60
M L QL LLLWKN TL++R V E+F+PL+ IL+ LR K + +V + Y
Sbjct: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIY--- 57
Query: 61 PLTSAGILPVMQSLCPDGQRDEFGFL---QYANSTVTQLLER 99
P S LP+ + P G E ++ A TVT+ + R
Sbjct: 58 PGQSIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRR 99
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 514 bits (1325), Expect = e-145
Identities = 305/929 (32%), Positives = 513/929 (55%), Gaps = 76/929 (8%)
Query: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEI-RSFLEQ--GRLQQHLR- 514
KILY P E+++VI KAN TF V + ++ L +S+ RS Q +LQ+ LR
Sbjct: 3317 KILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSSLFQRSGSGQMFNQLQEALRN 3376
Query: 515 -WLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQFMS 573
+++ +V E +LH + +D+L L+ LL ++ ++A G +F+
Sbjct: 3377 KFVRNFV-ENQLH-----IDVDKLTEKLQTYG-------GLLDEM--FNHAGAGRFRFLG 3421
Query: 574 KVSVDI--------FKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTR--------KDGS 617
+ V++ F+ + I+ ++ Q N + AS+IF +
Sbjct: 3422 SILVNLSSCVALNRFQALQSVD-ILETKAHELLQQN-SFLASIIFSNSLFDKNFRSESVK 3479
Query: 618 LPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNT--GGRFYFLYGFVWIQDMMERAIIDTF 675
LPPHV Y IR N ++ +T+ ++ W+ P F + Y F +QDM+ERAII
Sbjct: 3480 LPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPLQDMIERAIILVQ 3539
Query: 676 VGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRL 735
G + +EP + Q PYPC+T D FL + PL M+++W+ SVA ++ +V E+E ++
Sbjct: 3540 TGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQI 3599
Query: 736 KEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAV 795
+E M+ MG++ +H++AWF+ L+IS L +LK + HS+ I++LFL + +
Sbjct: 3600 EEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGM 3659
Query: 796 ATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMS 855
+ +M +L+S +S+A A+ C ++Y +S++PY+ + V H++++ + L+S
Sbjct: 3660 SVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLL----VLHNQLSFVNQTFLCLLS 3715
Query: 856 TTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIE 915
TTAFG G + E GIQW+ Q+ +E M++ D+ +Y + WY+
Sbjct: 3716 TTAFGQGVFFITFLEGQETGIQWNNMYQA-LEQGGMTFGWVCWMILFDSSLYFLCGWYLS 3774
Query: 916 AVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFE 975
+ PG +GL +PWYFP SYW G + + + +++ ++++R E
Sbjct: 3775 NLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGE 3834
Query: 976 ETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTM 1035
+E + LV +TK Y + K + LSL Y +Q+ + LG NGAGKTT +
Sbjct: 3835 ----LEGSAPGVTLV----SVTKEY-EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTII 3885
Query: 1036 SILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKS- 1094
S+LTGL PPTSG+ I G +++T++ +R LG+CPQ ++L D LTV EHL ++ +K+
Sbjct: 3886 SMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAP 3945
Query: 1095 -MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAG 1153
++E+ +++++ ++D++L+ +H + LSGG+KRKLS+ IAF+G SR ++LDEPT+G
Sbjct: 3946 QWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSG 4005
Query: 1154 VDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTY 1213
VDP +R ++WD++LKY+ GRTI+ +THH+DEA+ L DR+A++ HG+L+CCG P LK Y
Sbjct: 4006 VDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAY 4065
Query: 1214 GDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTST 1273
G G RLTL ++P+ +A V+ I+ ++ L + +
Sbjct: 4066 GQGLRLTLTRQPSVLEAHDLKDMAC---------------VTSLIKIYIPQAFLKDSSGS 4110
Query: 1274 ELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSE 1333
EL+Y +P + K + LFQ L+ +L LHL+ +G+ DTTLEEVFL + ++ N +
Sbjct: 4111 ELTYTIPKD-TDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQD----SNKK 4165
Query: 1334 ADVKESRKDVLPGAEGPASGEGHAGNLAR 1362
+ + + L G+ G+LAR
Sbjct: 4166 SHIALGTESELQNHRPTGHLSGYCGSLAR 4194
Score = 466 bits (1199), Expect = e-130
Identities = 332/956 (34%), Positives = 473/956 (49%), Gaps = 131/956 (13%)
Query: 1439 QFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNY 1498
Q +L +R R K+ + +LLP FV +AM + + P + PP
Sbjct: 4207 QVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPP----------- 4255
Query: 1499 TQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLN 1558
LRL+P Q T+ SG G L+
Sbjct: 4256 -------------------LRLTP--GHYQRAETYFFSSG---------------GDNLD 4279
Query: 1559 LSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPP 1618
L+ R+L +F D Q LP ++ P ++ W P
Sbjct: 4280 LT----RVLLRKFRD--------QDLPCADLNPR-------------QKNSSCWRTD--P 4312
Query: 1619 TAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHN 1678
+ PE S C C CP+ P + G L +++G N
Sbjct: 4313 FSHPEFQDS-------------CGC------LKCPNR-SASAPYLTNHLGHTLLNLSGFN 4352
Query: 1679 VSEYLLFTSDRFRLHRYGAITFGNVLKSIP--ASFGTRAPPMVRKIAVRRAAQVFYNNKG 1736
+ EYLL S++ RL G +FG + S A+ PP + A+V+YN KG
Sbjct: 4353 MEEYLLAPSEKPRL---GGWSFGLKIPSEAGGANGNISKPPTL--------AKVWYNQKG 4401
Query: 1737 YHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGT-DVVI 1795
+HS+P+YLN LNN IL +LP + + YGIT+ +HP A L+ D +L+ +
Sbjct: 4402 FHSLPSYLNHLNNLILWQHLPPTV-DWRQYGITLYSHPYG--GALLNKDKILESIRQCGV 4458
Query: 1796 AIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCC 1855
A+ I++ S + AS +V ++ AK LQ +SG +YW N+++DML YLV C
Sbjct: 4459 ALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLC 4518
Query: 1856 VIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFI 1915
V ++ F L A+T N A L L+G++ P MY S F A++ + +N
Sbjct: 4519 VAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIF 4578
Query: 1916 GITATVATF---LLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYA 1972
G+ + T LL + K+L+ + LK F IFP + LG GL+E+ YN+ +
Sbjct: 4579 GLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTH 4638
Query: 1973 KIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVED-- 2030
G D SPFE + + V +A +G V LL ++ ++ LR P+ V+
Sbjct: 4639 NFG-IDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPRGHSTLQGTVKSSK 4697
Query: 2031 DVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVN 2090
D DV E +RV G + D++ + NL+K Y+ R I+AV + LG+ GECFGLLGVN
Sbjct: 4698 DTDVEKEEKRVFEGRTNGDILVLYNLSKHYR-RFFQNIIAVQDISLGIPKGECFGLLGVN 4756
Query: 2091 GAGKTSTFKMLTGDESTTGGEAFVN---GHSV-LKELLQVQQSLGYCPQCDALFDELTAR 2146
GAGK++TFKML G+ S T G A + G +V L +GYCPQ DAL + LT
Sbjct: 4757 GAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGW 4816
Query: 2147 EHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPA 2206
EHL Y LRGI + V + +L L +ADKP TYSGG KRKLSTA+AL+G P
Sbjct: 4817 EHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPD 4876
Query: 2207 FIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRC 2266
+ LDEP++GMDP ++R+LW I+ ++ G + VLTSHSMEECEALCTRLAIMVNG +C
Sbjct: 4877 ILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKC 4936
Query: 2267 LGSIQHLKNRFGDGYMITV----RTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLK 2322
LGS QH+KNRFGDGY + V +V D ++ + FP K +H ++Y +
Sbjct: 4937 LGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLY---FPGIQFKGQHLNLLEYHVP 4993
Query: 2323 SEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPS 2378
LA +F +E L I+ YS++QTTL+ VF+NFA +Q L Q T PS
Sbjct: 4994 KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTL--QSTLDPS 5047
Score = 195 bits (495), Expect = 5e-49
Identities = 166/617 (26%), Positives = 287/617 (46%), Gaps = 64/617 (10%)
Query: 1785 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
D L + +++ AS V LV E+ + + + G +P+I++LA ++ +
Sbjct: 3562 DLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLEN 3621
Query: 1845 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLL-YGWSITPIMYPASFWFEVPSS 1903
M + + I+L + A+++ ++ LFLL +G S+ + Y S +F ++
Sbjct: 3622 MAVLTISSATLAIVLKTSGIFAHSNTF----IVFLFLLDFGMSVVMLSYLLSAFFSQANT 3677
Query: 1904 AYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAY 1963
A + ++ + + +++ L H++ V ++L C L + G G+ + +
Sbjct: 3678 AALCTSLVYMI-----SFLPYIVLLVLHNQLSFVNQTFL--CLLSTTAF--GQGVFFITF 3728
Query: 1964 NEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAV------EGVVGFLLTIMCQYNF-LR 2016
E Q++ M E +T G V + + G+ L+ + F LR
Sbjct: 3729 LEGQETGI----QWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLR 3784
Query: 2017 RPQRMPVSTKPVEDDVDVASERQRVLRGDA-------DNDMVKIEN-------------- 2055
+P P + + + +RQ L DN ++N
Sbjct: 3785 KPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGSAPGVTL 3844
Query: 2056 --LTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAF 2113
+TK Y+ K V L L + LLG NGAGKT+ MLTG T G
Sbjct: 3845 VSVTKEYEGHKA----VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTII 3900
Query: 2114 VNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW--KDEARVVKWAL 2171
+NG ++ +L +V+ LG CPQ D L D LT REHL L+ ++ W K+ + V L
Sbjct: 3901 INGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTL 3960
Query: 2172 EKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILD 2231
+ ++LT++ K SGG KRKLS IA +G + LDEPT+G+DP +R LW+++L
Sbjct: 3961 QDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLK 4020
Query: 2232 LIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSS- 2290
+ GR+++ T+H ++E EAL R+A++ +GRLRC G LK +G G +T+ + S
Sbjct: 4021 -YREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSV 4079
Query: 2291 ---QSVKD---VVRFFNRNFPEAMLKERHHTKVQYQL--KSEHISLAQVFSKMEQVSGVL 2342
+KD V P+A LK+ +++ Y + ++ L +F +++ L
Sbjct: 4080 LEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQL 4139
Query: 2343 GIEDYSVSQTTLDNVFV 2359
+ Y +S TTL+ VF+
Sbjct: 4140 HLTGYGISDTTLEEVFL 4156
Score = 158 bits (399), Expect = 7e-38
Identities = 165/647 (25%), Positives = 276/647 (42%), Gaps = 82/647 (12%)
Query: 710 LCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALT 769
LC+V+ + A +V ++ K + GL ++W F+ + +SV
Sbjct: 4460 LCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCV 4519
Query: 770 AILKYGQVL---MHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSY 826
A++ Q+ ++ L L+++ AT+ + +L+S ++S + +A F+SY
Sbjct: 4520 AVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVA--------FISY 4571
Query: 827 VPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPV 886
V ++ + IT + +A + + A L + Y L V + Q+ Q V
Sbjct: 4572 VSLNFIF---GLCTMLITIMPRLLAII--SKAKNLQNIYDVLKWVFTIFPQF-CLGQGLV 4625
Query: 887 EGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYF---PLQKSYWLGSGRT 943
E L + D + Y+ G W F Q + L
Sbjct: 4626 E-------LCYNQIKYDLTHNFGIDSYVSPFEMNFLG----WIFVQLASQGTVLLLLRVL 4674
Query: 944 EAWEW-SWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKD 1002
W+ WP + ++ + +E EE R E LV+ L+K Y+
Sbjct: 4675 LHWDLLRWPRGHSTLQGTVKSSKDTDVEK---EEKRVFEGRTNGDILVLY--NLSKHYRR 4729
Query: 1003 --DKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
+A+ +SL + + + LG NGAGK+TT +L G TSG A I RT M
Sbjct: 4730 FFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAII-----RTPM 4784
Query: 1061 -DEIRKN--------LGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDL 1111
D + + +G CPQ + L + LT EHL++Y L+ + ++ I +I L
Sbjct: 4785 GDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRL 4844
Query: 1112 ELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK-YK 1170
L V T SGG KRKLS A+A VG ++LDEP++G+DP ++R +W I+K +
Sbjct: 4845 HLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVR 4904
Query: 1171 PGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGY--RLTLVKRPAEP 1228
G +L++H M+E + L R+AI+ +G KC GSP +K +GDGY ++ L K +
Sbjct: 4905 EGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQ- 4963
Query: 1229 GGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGA 1288
VS ++ + L Y +P + G
Sbjct: 4964 ----------------------HCTVSDHLKLYFPGIQFKGQHLNLLEYHVPK---RWGC 4998
Query: 1289 FERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEAD 1335
LF+ +E + L++ + + TTLE+VF+ + E Q S D
Sbjct: 4999 LADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTLQSTLD 5045
Score = 48.9 bits (115), Expect = 6e-05
Identities = 28/76 (36%), Positives = 42/76 (55%), Gaps = 2/76 (2%)
Query: 6 QLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSA 65
Q + LLWKN + R+P + E F P +LF IL LR ++P +++ + L S
Sbjct: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPP-RYRDICYLQPRDLPSC 65
Query: 66 GILPVMQS-LCPDGQR 80
G++P +QS LC G R
Sbjct: 66 GVIPFVQSLLCNTGSR 81
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 300 bits (767), Expect = 2e-80
Identities = 198/608 (32%), Positives = 316/608 (51%), Gaps = 63/608 (10%)
Query: 726 HIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLM-HSHVV 784
HIVAEKE ++KE +K MGL++ W++W + + L ++ L A++ +L S +
Sbjct: 239 HIVAEKEKKIKEFLKIMGLHDTAFWLSWVLL-YTSLIFLMSLLMAVIATASLLFPQSSSI 297
Query: 785 IIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKIT 844
+I+L +Y ++++ F +++ L+ K+K GI+ F V + ++ + + I
Sbjct: 298 VIFLLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIIL----IE 349
Query: 845 AFEKCIASLMST---TAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM 901
+F K + L S F +G E G + + P + L++ + ML
Sbjct: 350 SFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGP-----YPLIITIIMLT 404
Query: 902 VDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVM 961
++++ Y +L Y++ V PG +GL R + L+ SYW S R +E +S
Sbjct: 405 LNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRN--YEELSEGNVNGNISFS 462
Query: 962 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQ 1019
E + + E E R + + K Y K + AL LS ++YE Q
Sbjct: 463 EIIEPVSSEFVGKEAIR--------------ISGIQKTYRKKGENVEALRNLSFDIYEGQ 508
Query: 1020 VVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT--EMDEIRKNLGMCPQHNVLF 1077
+ + LGH+G GK+T M+IL GL PP+ G A+IYGH + EM E RK +G+CPQ ++ F
Sbjct: 509 ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHF 568
Query: 1078 DRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIA 1137
D LTVEE+L + +K + I +E+ K++ DL++ + + + LSGG KRKLS+ IA
Sbjct: 569 DVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIA 628
Query: 1138 FVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISH 1197
+G + ++LDEPTAG+DP +R +W+L+ K R + STH MDEAD+L DR A+IS
Sbjct: 629 VLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQ 688
Query: 1198 GKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQF 1257
G LKC GS +FLK +G GYRL++ C+ +S
Sbjct: 689 GMLKCVGSSMFLKSKWGIGYRLSMYID----------------------KYCATESLSSL 726
Query: 1258 IRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEE 1317
+++H+ L+ +L Y LP + K F LF L+ S L + S+G+ TTLE+
Sbjct: 727 VKQHIPGATLLQQNDQQLVYSLPFKDMDK--FSGLFSALD-SHSNLGVISYGVSMTTLED 783
Query: 1318 VFLKVSEE 1325
VFLK+ E
Sbjct: 784 VFLKLEVE 791
Score = 238 bits (608), Expect = 4e-62
Identities = 199/699 (28%), Positives = 315/699 (45%), Gaps = 115/699 (16%)
Query: 1732 YNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGT 1791
+N+ +S+P +N ++N L Y + VT +T S + + T
Sbjct: 972 FNSTMVYSLPILVNIISNYYL-------------YHLNVT-----ETIQIWSTPFFQEIT 1013
Query: 1792 DVVIAIFII-------VAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
D+V I + + ++ +P F + KA +SG P YW+ V D
Sbjct: 1014 DIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVD 1073
Query: 1845 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFE----- 1899
+ + + + L F Y F AV+ + Y S+ Y ASF F+
Sbjct: 1074 IPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNT 1133
Query: 1900 ---------VPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSY-LKSCFLIF 1949
V + A + + I F+G T +AT L F ++ Y L C + F
Sbjct: 1134 KEFWSFIYSVAALACIAITEITFFMGYT--IATILHYAF-----CIIIPIYPLLGCLISF 1186
Query: 1950 ------------PNYNLGHGLMEMAYNEYIN--------EYYAK-IGQFDKMKSPFEWDI 1988
YN L + Y+ +YY K G K PF ++
Sbjct: 1187 IKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNL 1246
Query: 1989 VTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRV--LRGDA 2046
T+ + +++P ++D DV +ER +V L G
Sbjct: 1247 STKS------------------------KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQ 1282
Query: 2047 ---DNDMVKIENLTKVYK-------SRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTS 2096
+ + + NL K Y SRK+ ++ A + V+ GE GLLG NGAGK++
Sbjct: 1283 CCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV-ATKYISFCVKKGEILGLLGPNGAGKST 1341
Query: 2097 TFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSL---GYCPQCDALFDELTAREHLQLYT 2153
+L GD T G+ F+ +S E + SL GYCPQ + L+ + T +EH ++Y
Sbjct: 1342 IINILVGDIEPTSGQVFLGDYS--SETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYG 1399
Query: 2154 RLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEP 2213
++G+S D V+ L+L ++ K G KRKL A++++G P LDEP
Sbjct: 1400 AVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEP 1459
Query: 2214 TTGMDPKARRFLWNLILDLIKT-GRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQH 2272
+TGMDPKA++ +W I K R+ +LT+H MEE EA+C R+AIMV+G+LRC+G++QH
Sbjct: 1460 STGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQH 1519
Query: 2273 LKNRFGDGYMITVRTK---SSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHI-SL 2328
LK++FG GY + ++ K + V + R FP A +E + + Y++ E + SL
Sbjct: 1520 LKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSL 1579
Query: 2329 AQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSD 2367
+Q F K+E+ IE+YS SQ TL+ VFV K+Q +
Sbjct: 1580 SQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618
Score = 179 bits (454), Expect = 3e-44
Identities = 156/600 (26%), Positives = 273/600 (45%), Gaps = 67/600 (11%)
Query: 1794 VIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPAT 1853
VI I++++A S + +VAEK K K + G + +WL+ W +L T
Sbjct: 220 VILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLS---WVLLY-----T 271
Query: 1854 CCVIILFVFDLPAYTSPTNFP-----AVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFL 1908
+ ++ + T+ FP + LF LYG S S + L
Sbjct: 272 SLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLS----------------SVFFAL 315
Query: 1909 IVINLF-----IGIT---ATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNY---NLGHG 1957
++ LF +GI TVA + L + ++ S+ KS +F + G
Sbjct: 316 MLTPLFKKSKHVGIVEFFVTVAFGFIGLM-----IILIESFPKSLVWLFSPFCHCTFVIG 370
Query: 1958 LMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGL-------VAMAVEGVVGFLLTIMC 2010
+ ++ + E NE A P I+ L +A+ ++ V+ +
Sbjct: 371 IAQVMHLEDFNEG-ASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRR 429
Query: 2011 QYNFLRRPQRMPVSTKPVED--------DVDVASERQRVLRGDADNDMVKIENLTKVYKS 2062
+ +P S + E+ ++ + + V + ++I + K Y+
Sbjct: 430 SSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYR- 488
Query: 2063 RKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSV--L 2120
+K + A+ L + G+ LLG +G GK++ +L G + G A + GH V +
Sbjct: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548
Query: 2121 KELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYA 2180
E+ + ++ +G CPQ D FD LT E+L + ++GI + + V+ L L++
Sbjct: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIK 608
Query: 2181 DKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVV 2240
D A SGG KRKLS IA++G P + LDEPT GMDP +R +WNL L K R V
Sbjct: 609 DNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNL-LKYRKANRVTV 667
Query: 2241 LTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFF 2300
++H M+E + L R A++ G L+C+GS LK+++G GY +++ + + +
Sbjct: 668 FSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLV 727
Query: 2301 NRNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFV 2359
++ P A L +++ ++ Y L + + + +FS ++ S LG+ Y VS TTL++VF+
Sbjct: 728 KQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFL 786
Score = 161 bits (408), Expect = 6e-39
Identities = 158/633 (24%), Positives = 278/633 (43%), Gaps = 86/633 (13%)
Query: 731 KEHRLKEV--MKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWL 788
+ H++K +K GL + +W+ G + I + + IL G +L + + +
Sbjct: 1045 ENHKIKAYTQLKLSGLLPSAYWI-----GQAVVDIPLFFIILILMLGSLLAFHYGLYFYT 1099
Query: 789 --FLAV------YAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 840
FLAV Y + I+F ++ S + K IY VA +A
Sbjct: 1100 VKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYS--------VAALACIAI 1151
Query: 841 DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEG--DDFN----LL 894
+IT F + + AF + +Y + G I + S V D +N L
Sbjct: 1152 TEITFFMGYTIATILHYAFCI---IIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLS 1208
Query: 895 LAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWAR 954
+AV + V++ L Y E + G P++ L T++ P
Sbjct: 1209 VAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLS---------TKSKNRKLPEPP 1259
Query: 955 TPRLSVMEEDQACAMESRRFEETRGM---EEEPTHLPLVVCVDKLTKVYKDDK------- 1004
+ED+ E + +E G EE+P+ + V L K Y D K
Sbjct: 1260 DNE----DEDEDVKAERLKVKELMGCQCCEEKPS-----IMVSNLHKEYDDKKDFLLSRK 1310
Query: 1005 --KLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT-EMD 1061
K+A +S + + +++ LG NGAGK+T ++IL G PTSG + + T E D
Sbjct: 1311 VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD 1370
Query: 1062 EIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLV 1121
+ K +G CPQ N L+ T++EH Y +K M+ +++ + ++ L+L V
Sbjct: 1371 DSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV 1430
Query: 1122 QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLST 1179
+ L G+KRKL A++ +G + +LDEP+ G+DP A++ +W I R +L+T
Sbjct: 1431 KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTT 1490
Query: 1180 HHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASS 1239
H+M+EA+ + DR+AI+ G+L+C G+ LK +G GY L + +
Sbjct: 1491 HYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDW------------- 1537
Query: 1240 PPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERS 1299
+ + ++ + I+ + S+ L+Y +P E + + + F LE +
Sbjct: 1538 ------IENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQ--SLSQSFFKLEEA 1589
Query: 1300 LDALHLSSFGLMDTTLEEVFLKVSEEDQSLENS 1332
A + + TLE+VF+++++E + +NS
Sbjct: 1590 KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 300 bits (767), Expect = 2e-80
Identities = 198/608 (32%), Positives = 316/608 (51%), Gaps = 63/608 (10%)
Query: 726 HIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLM-HSHVV 784
HIVAEKE ++KE +K MGL++ W++W + + L ++ L A++ +L S +
Sbjct: 239 HIVAEKEKKIKEFLKIMGLHDTAFWLSWVLL-YTSLIFLMSLLMAVIATASLLFPQSSSI 297
Query: 785 IIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKIT 844
+I+L +Y ++++ F +++ L+ K+K GI+ F V + ++ + + I
Sbjct: 298 VIFLLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIIL----IE 349
Query: 845 AFEKCIASLMST---TAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM 901
+F K + L S F +G E G + + P + L++ + ML
Sbjct: 350 SFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGP-----YPLIITIIMLT 404
Query: 902 VDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVM 961
++++ Y +L Y++ V PG +GL R + L+ SYW S R +E +S
Sbjct: 405 LNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRN--YEELSEGNVNGNISFS 462
Query: 962 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQ 1019
E + + E E R + + K Y K + AL LS ++YE Q
Sbjct: 463 EIIEPVSSEFVGKEAIR--------------ISGIQKTYRKKGENVEALRNLSFDIYEGQ 508
Query: 1020 VVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT--EMDEIRKNLGMCPQHNVLF 1077
+ + LGH+G GK+T M+IL GL PP+ G A+IYGH + EM E RK +G+CPQ ++ F
Sbjct: 509 ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHF 568
Query: 1078 DRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIA 1137
D LTVEE+L + +K + I +E+ K++ DL++ + + + LSGG KRKLS+ IA
Sbjct: 569 DVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIA 628
Query: 1138 FVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISH 1197
+G + ++LDEPTAG+DP +R +W+L+ K R + STH MDEAD+L DR A+IS
Sbjct: 629 VLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQ 688
Query: 1198 GKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQF 1257
G LKC GS +FLK +G GYRL++ C+ +S
Sbjct: 689 GMLKCVGSSMFLKSKWGIGYRLSMYID----------------------KYCATESLSSL 726
Query: 1258 IRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEE 1317
+++H+ L+ +L Y LP + K F LF L+ S L + S+G+ TTLE+
Sbjct: 727 VKQHIPGATLLQQNDQQLVYSLPFKDMDK--FSGLFSALD-SHSNLGVISYGVSMTTLED 783
Query: 1318 VFLKVSEE 1325
VFLK+ E
Sbjct: 784 VFLKLEVE 791
Score = 238 bits (608), Expect = 4e-62
Identities = 199/699 (28%), Positives = 315/699 (45%), Gaps = 115/699 (16%)
Query: 1732 YNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGT 1791
+N+ +S+P +N ++N L Y + VT +T S + + T
Sbjct: 972 FNSTMVYSLPILVNIISNYYL-------------YHLNVT-----ETIQIWSTPFFQEIT 1013
Query: 1792 DVVIAIFII-------VAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
D+V I + + ++ +P F + KA +SG P YW+ V D
Sbjct: 1014 DIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVD 1073
Query: 1845 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFE----- 1899
+ + + + L F Y F AV+ + Y S+ Y ASF F+
Sbjct: 1074 IPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNT 1133
Query: 1900 ---------VPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSY-LKSCFLIF 1949
V + A + + I F+G T +AT L F ++ Y L C + F
Sbjct: 1134 KEFWSFIYSVAALACIAITEITFFMGYT--IATILHYAF-----CIIIPIYPLLGCLISF 1186
Query: 1950 ------------PNYNLGHGLMEMAYNEYIN--------EYYAK-IGQFDKMKSPFEWDI 1988
YN L + Y+ +YY K G K PF ++
Sbjct: 1187 IKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNL 1246
Query: 1989 VTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRV--LRGDA 2046
T+ + +++P ++D DV +ER +V L G
Sbjct: 1247 STKS------------------------KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQ 1282
Query: 2047 ---DNDMVKIENLTKVYK-------SRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTS 2096
+ + + NL K Y SRK+ ++ A + V+ GE GLLG NGAGK++
Sbjct: 1283 CCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV-ATKYISFCVKKGEILGLLGPNGAGKST 1341
Query: 2097 TFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSL---GYCPQCDALFDELTAREHLQLYT 2153
+L GD T G+ F+ +S E + SL GYCPQ + L+ + T +EH ++Y
Sbjct: 1342 IINILVGDIEPTSGQVFLGDYS--SETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYG 1399
Query: 2154 RLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEP 2213
++G+S D V+ L+L ++ K G KRKL A++++G P LDEP
Sbjct: 1400 AVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEP 1459
Query: 2214 TTGMDPKARRFLWNLILDLIKT-GRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQH 2272
+TGMDPKA++ +W I K R+ +LT+H MEE EA+C R+AIMV+G+LRC+G++QH
Sbjct: 1460 STGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQH 1519
Query: 2273 LKNRFGDGYMITVRTK---SSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHI-SL 2328
LK++FG GY + ++ K + V + R FP A +E + + Y++ E + SL
Sbjct: 1520 LKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSL 1579
Query: 2329 AQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSD 2367
+Q F K+E+ IE+YS SQ TL+ VFV K+Q +
Sbjct: 1580 SQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618
Score = 179 bits (454), Expect = 3e-44
Identities = 156/600 (26%), Positives = 273/600 (45%), Gaps = 67/600 (11%)
Query: 1794 VIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPAT 1853
VI I++++A S + +VAEK K K + G + +WL+ W +L T
Sbjct: 220 VILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLS---WVLLY-----T 271
Query: 1854 CCVIILFVFDLPAYTSPTNFP-----AVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFL 1908
+ ++ + T+ FP + LF LYG S S + L
Sbjct: 272 SLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLS----------------SVFFAL 315
Query: 1909 IVINLF-----IGIT---ATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNY---NLGHG 1957
++ LF +GI TVA + L + ++ S+ KS +F + G
Sbjct: 316 MLTPLFKKSKHVGIVEFFVTVAFGFIGLM-----IILIESFPKSLVWLFSPFCHCTFVIG 370
Query: 1958 LMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGL-------VAMAVEGVVGFLLTIMC 2010
+ ++ + E NE A P I+ L +A+ ++ V+ +
Sbjct: 371 IAQVMHLEDFNEG-ASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRR 429
Query: 2011 QYNFLRRPQRMPVSTKPVED--------DVDVASERQRVLRGDADNDMVKIENLTKVYKS 2062
+ +P S + E+ ++ + + V + ++I + K Y+
Sbjct: 430 SSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYR- 488
Query: 2063 RKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSV--L 2120
+K + A+ L + G+ LLG +G GK++ +L G + G A + GH V +
Sbjct: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548
Query: 2121 KELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYA 2180
E+ + ++ +G CPQ D FD LT E+L + ++GI + + V+ L L++
Sbjct: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIK 608
Query: 2181 DKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVV 2240
D A SGG KRKLS IA++G P + LDEPT GMDP +R +WNL L K R V
Sbjct: 609 DNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNL-LKYRKANRVTV 667
Query: 2241 LTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFF 2300
++H M+E + L R A++ G L+C+GS LK+++G GY +++ + + +
Sbjct: 668 FSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLV 727
Query: 2301 NRNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFV 2359
++ P A L +++ ++ Y L + + + +FS ++ S LG+ Y VS TTL++VF+
Sbjct: 728 KQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFL 786
Score = 161 bits (408), Expect = 6e-39
Identities = 158/633 (24%), Positives = 278/633 (43%), Gaps = 86/633 (13%)
Query: 731 KEHRLKEV--MKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWL 788
+ H++K +K GL + +W+ G + I + + IL G +L + + +
Sbjct: 1045 ENHKIKAYTQLKLSGLLPSAYWI-----GQAVVDIPLFFIILILMLGSLLAFHYGLYFYT 1099
Query: 789 --FLAV------YAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 840
FLAV Y + I+F ++ S + K IY VA +A
Sbjct: 1100 VKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYS--------VAALACIAI 1151
Query: 841 DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEG--DDFN----LL 894
+IT F + + AF + +Y + G I + S V D +N L
Sbjct: 1152 TEITFFMGYTIATILHYAFCI---IIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLS 1208
Query: 895 LAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWAR 954
+AV + V++ L Y E + G P++ L T++ P
Sbjct: 1209 VAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLS---------TKSKNRKLPEPP 1259
Query: 955 TPRLSVMEEDQACAMESRRFEETRGM---EEEPTHLPLVVCVDKLTKVYKDDK------- 1004
+ED+ E + +E G EE+P+ + V L K Y D K
Sbjct: 1260 DNE----DEDEDVKAERLKVKELMGCQCCEEKPS-----IMVSNLHKEYDDKKDFLLSRK 1310
Query: 1005 --KLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT-EMD 1061
K+A +S + + +++ LG NGAGK+T ++IL G PTSG + + T E D
Sbjct: 1311 VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD 1370
Query: 1062 EIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLV 1121
+ K +G CPQ N L+ T++EH Y +K M+ +++ + ++ L+L V
Sbjct: 1371 DSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV 1430
Query: 1122 QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLST 1179
+ L G+KRKL A++ +G + +LDEP+ G+DP A++ +W I R +L+T
Sbjct: 1431 KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTT 1490
Query: 1180 HHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASS 1239
H+M+EA+ + DR+AI+ G+L+C G+ LK +G GY L + +
Sbjct: 1491 HYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDW------------- 1537
Query: 1240 PPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERS 1299
+ + ++ + I+ + S+ L+Y +P E + + + F LE +
Sbjct: 1538 ------IENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQ--SLSQSFFKLEEA 1589
Query: 1300 LDALHLSSFGLMDTTLEEVFLKVSEEDQSLENS 1332
A + + TLE+VF+++++E + +NS
Sbjct: 1590 KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 296 bits (757), Expect = 2e-79
Identities = 223/777 (28%), Positives = 376/777 (48%), Gaps = 101/777 (12%)
Query: 582 GFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHY--KIRQNSSFTEKTNEI 639
G+PDE+S+ LN + D V V + F S + + R +S+ + NE
Sbjct: 107 GWPDEKSMDELDLNYSI-DAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEK 165
Query: 640 RRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVEP-----GSYVQMFPYPC 694
+ G ++ GFV Q + AII+ H V+E G ++++ P+
Sbjct: 166 MKCE--------GSEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVA 217
Query: 695 Y---TRDDFLFVIEHMMPLCMVI--SWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVH 749
D F+F C++ +++Y V++ V ++ + +M MGL +
Sbjct: 218 QGGVATDFFIF-------FCIISFSTFIYYVSVN----VTQERQYITSLMTMMGLRESAF 266
Query: 750 WVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYS 809
W++W + + I T + I+K Q+++ + V+++ +Y ++ I FL+SVL
Sbjct: 267 WLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIK 326
Query: 810 KAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALY 869
K L G++ FL V + + + ++ AF + L+S AF +G
Sbjct: 327 KPFLT----GLVVFLLIVFWGILGF--PALYTRLPAFLEWTLCLLSPFAFTVGMAQL--- 377
Query: 870 EVAGVGIQWHTFSQSPVEGDDFNLLLAVT--MLMVDAVVYGILTWYIEAVHPGMYGLPRP 927
+ + + S + ++ L+ T ML+ D ++Y +LT Y + + P YG
Sbjct: 378 ----IHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCS 433
Query: 928 WYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFE----ETRGMEEE 983
F L+ +W GR + + E + + FE E G E
Sbjct: 434 PLFFLKSCFWFQHGRAN------------HVVLENETDSDPTPNDCFEPVSPEFCGKE-- 479
Query: 984 PTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGL 1041
+ + L K Y K ++ AL + ++YE Q+ + LGH+GAGKTT ++IL+GL
Sbjct: 480 ------AIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGL 533
Query: 1042 FPPTSGSATIYGHDIR--TEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEE 1099
PTSGS T+Y H + +++ I K G CPQ NV F LTV+E+L ++++K + E
Sbjct: 534 SVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHE 593
Query: 1100 IRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYAR 1159
+ +E+ +++++LE+ N + L Q LSGG RKL+ IA +G + ++LDEPTAG+DP +R
Sbjct: 594 VEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSR 653
Query: 1160 RAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRL 1219
IW+L+ + K R IL ST +DEAD+L DR IS+GKLKC GS LFLK +G GY L
Sbjct: 654 HRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL 713
Query: 1220 TLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYIL 1279
+L C ++ +++H++ L + + +L YIL
Sbjct: 714 SLHLN----------------------ERCDPESITSLVKQHISDAKLTAQSEEKLVYIL 751
Query: 1280 PSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADV 1336
P E K F L++ L+R + + +G+ TTL EVFLK+ E +++ S+ +
Sbjct: 752 PLERTNK--FPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKL-EGKSTIDESDIGI 804
Score = 228 bits (580), Expect = 7e-59
Identities = 132/368 (35%), Positives = 211/368 (57%), Gaps = 17/368 (4%)
Query: 2022 PVSTKPVEDDVDVASERQRVLRGDADND-----MVKIENLTKVYKSRKIG------RILA 2070
P +P ++ D+ ER R + A D ++ L K Y +K + +A
Sbjct: 1249 PNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIA 1308
Query: 2071 VDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSL 2130
+ V+ GE GLLG NGAGK++T KM+TGD T G+ + G + L L
Sbjct: 1309 TRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL----GFL 1364
Query: 2131 GYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGG 2190
GYCPQ +AL+ LT R+HL++Y ++G+ D + ++ L+L P T S G
Sbjct: 1365 GYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEG 1424
Query: 2191 NKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK-TGRSVVLTSHSMEEC 2249
KRKL ++++G P+ + LDEP+TGMDP+ ++ +W +I + T R +LT+H M E
Sbjct: 1425 IKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEA 1484
Query: 2250 EALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAML 2309
EA+C R+AIMV+GRLRC+GSIQHLK++FG Y++ ++ K+ ++ + R FP+A
Sbjct: 1485 EAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQ 1544
Query: 2310 KERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2368
+ER + + Y+L E + L+Q F K+E V +E+YS+SQ+TL+ VF+ +K+Q
Sbjct: 1545 QERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELG 1604
Query: 2369 LEQQETEP 2376
+++ +P
Sbjct: 1605 DLEEDFDP 1612
Score = 176 bits (446), Expect = 3e-43
Identities = 153/631 (24%), Positives = 291/631 (46%), Gaps = 63/631 (9%)
Query: 1771 TNHPMNKTSASLS------LDYLLQG---TDVVIAIFIIVAMSFVPASFVVFLVAEKSTK 1821
TNH + + S++ L ++ QG TD I II +F+ +V V ++
Sbjct: 194 TNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFI--YYVSVNVTQERQY 251
Query: 1822 AKHLQFVSGCNPIIYWLANYVWDMLN---YLVPATCCVIILFVFDLPAYTSPTNFPAVLS 1878
L + G +WL+ W ++ L+ AT +I+ + T F V +
Sbjct: 252 ITSLMTMMGLRESAFWLS---WGLMYAGFILIMATLMALIVKSAQIVVLTG---FVMVFT 305
Query: 1879 LFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVV 1938
LFLLYG S+ + + S + P + + ++ +F GI A + +
Sbjct: 306 LFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTR-----------L 354
Query: 1939 NSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAV 1998
++L+ + + G+ ++ + +Y A + D ++P+ ++ L +
Sbjct: 355 PAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHL---DSSQNPY---LIIATLFMLVF 408
Query: 1999 EGVVGFLLTIM------CQYNFLRRP----------QRMPVSTKPVEDDVDVASER---- 2038
+ ++ +LT+ +Y P Q + +E++ D
Sbjct: 409 DTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCF 468
Query: 2039 QRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTF 2098
+ V + ++I+NL K Y K R+ A+ + + G+ LLG +GAGKT+
Sbjct: 469 EPVSPEFCGKEAIRIKNLKKEYAG-KCERVEALKGVVFDIYEGQITALLGHSGAGKTTLL 527
Query: 2099 KMLTGDESTTGGEAFVNGHSV--LKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLR 2156
+L+G T G V H++ + ++ + + G+CPQ + F LT +E+L+L+ +++
Sbjct: 528 NILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIK 587
Query: 2157 GISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTG 2216
GI + + V+ +++LE+ D A SGG RKL+ IA++G P + LDEPT G
Sbjct: 588 GILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAG 647
Query: 2217 MDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNR 2276
+DP +R +WNL+ + K+ R ++ ++ ++E + L R + NG+L+C GS LK +
Sbjct: 648 LDPLSRHRIWNLLKE-GKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKK 706
Query: 2277 FGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKM 2335
+G GY +++ + + ++ +A L + K+ Y L E + +++ +
Sbjct: 707 WGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDL 766
Query: 2336 EQVSGVLGIEDYSVSQTTLDNVFVNFAKKQS 2366
++ S GIEDY VS TTL+ VF+ K +
Sbjct: 767 DRCSN-QGIEDYGVSITTLNEVFLKLEGKST 796
Score = 161 bits (408), Expect = 6e-39
Identities = 109/343 (31%), Positives = 173/343 (50%), Gaps = 31/343 (9%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K KK+A +S + + +V+ LGHNGAGK+TT+ ++TG PT+G + G +
Sbjct: 1302 KRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGG 1357
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1120
E LG CPQ N L+ LTV +HL Y+ +K + + + + ++++ L+L ++ +
Sbjct: 1358 GEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAP 1417
Query: 1121 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLS 1178
V+TLS G+KRKL ++ +G ++LDEP+ G+DP ++ +W +I R LL+
Sbjct: 1418 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLT 1477
Query: 1179 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1238
TH+M EA+ + DR+AI+ G+L+C GS LK +G Y L + + P +
Sbjct: 1478 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILR 1537
Query: 1239 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1298
P A S L V Y LP E + + F LE
Sbjct: 1538 LFPQAAQQERFSSLMV----------------------YKLPVEDVR--PLSQAFFKLEI 1573
Query: 1299 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRK 1341
+ L + L +TLE+VFL++S+E Q L + E D S K
Sbjct: 1574 VKQSFDLEEYSLSQSTLEQVFLELSKE-QELGDLEEDFDPSVK 1615
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 294 bits (752), Expect = 8e-79
Identities = 225/769 (29%), Positives = 373/769 (48%), Gaps = 75/769 (9%)
Query: 582 GFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRR 641
G PDEE++ + L + Y + V V S F R + + I+++S +TE +
Sbjct: 17 GTPDEETM-DIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPV-IKEHSEYTEHCWAMHG 74
Query: 642 AYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVEPGSYV---QMFPYPCYTRD 698
+ Y+L GFV Q + AII+ H V+E + V M P ++
Sbjct: 75 EIFCYLAK-----YWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKG 129
Query: 699 DFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGF 758
+ + H L S++Y ++ VA + + K++M MGL + W++W +T
Sbjct: 130 EIMNEWFHFTCLVSFSSFIYFASLN----VARERGKFKKLMTVMGLRESAFWLSWGLTYI 185
Query: 759 VQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACG 818
+ I + ++ ++ H+ ++I+ ++Y ++ I FL+SVL K LA G
Sbjct: 186 CFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAG 245
Query: 819 GIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQW 878
FL V + + V + ++ + SL+S AF G + G+ +
Sbjct: 246 ----FLFTV--FWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIF 299
Query: 879 HTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWL 938
S GD + ++ +L D + Y I T Y E V P G F L+ S+W
Sbjct: 300 PDPS-----GDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWS 354
Query: 939 GSGRT--EAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKL 996
T E +E P S + + + E E R + +
Sbjct: 355 KHQNTHHEIFENEI----NPEHSSDDSFEPVSPEFHGKEAIR--------------IRNV 396
Query: 997 TKVY--KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGH 1054
K Y K K AL + ++YE Q+ + LGHNGAGK+T ++IL+GL T GSATIY
Sbjct: 397 IKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNT 456
Query: 1055 DIR--TEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLE 1112
+ T+M+EIRKN+G CPQ N FD LTV E+L ++++K + +E+ +E+ ++I +L+
Sbjct: 457 QLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELD 516
Query: 1113 LSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPG 1172
+ + + + + LSGG KRKL++ IA +G + ++LDEPTAG+DP++R +W L+ ++K
Sbjct: 517 MQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVD 576
Query: 1173 RTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQ 1232
R IL ST MDEAD+L DR +S+GKLKC GS LFLK +G GY L+L +
Sbjct: 577 RLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRN-------- 628
Query: 1233 EPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERL 1292
C +++ I++H+ L +++ +L Y LP E K F L
Sbjct: 629 --------------EMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNK--FPDL 672
Query: 1293 FQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRK 1341
+ L++ D + ++ + T+L EVFL + E +++ + D+ + K
Sbjct: 673 YSDLDKCSDQ-GIRNYAVSVTSLNEVFLNL-EGKSAIDEPDFDIGKQEK 719
Score = 226 bits (575), Expect = 3e-58
Identities = 129/365 (35%), Positives = 209/365 (57%), Gaps = 15/365 (4%)
Query: 2016 RRPQRMPVSTKPVEDDVDVASERQRVLRGDA-----DNDMVKIENLTKVYKSRKIG---- 2066
R + P +P E+D DV +ER + + ++ L K Y K
Sbjct: 1156 RSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFST 1215
Query: 2067 --RILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGH--SVLKE 2122
+ +A+ + V+ GE GLLG NGAGK+++ KM+TG T G + G SV ++
Sbjct: 1216 RKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQ 1275
Query: 2123 LLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADK 2182
+ LGYCPQ ++L+ +LT +EHL+LY ++G+ +D A + +E L+L +
Sbjct: 1276 HDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKA 1335
Query: 2183 PAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKT-GRSVVL 2241
P T S G KRKL ++++G P+ + LDEP TGMDP+ ++ +W ++ +K R +L
Sbjct: 1336 PVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLL 1395
Query: 2242 TSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFN 2301
T+H M E EA+C R+A+MV+G LRC+GSIQHLKN+FG Y++ ++ K V+ +
Sbjct: 1396 TTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEIL 1455
Query: 2302 RNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVN 2360
+ FP+A +ER+ + + Y+L E + L++ F K+E + +E+YS+SQ TL+ VF+
Sbjct: 1456 KLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLE 1515
Query: 2361 FAKKQ 2365
K+Q
Sbjct: 1516 LCKEQ 1520
Score = 177 bits (449), Expect = 1e-43
Identities = 99/321 (30%), Positives = 182/321 (56%), Gaps = 6/321 (1%)
Query: 2049 DMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTT 2108
+ ++I N+ K Y K G++ A+ + + G+ +LG NGAGK++ +L+G +T
Sbjct: 389 EAIRIRNVIKEYNG-KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVST 447
Query: 2109 GGEAFVNGH--SVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARV 2166
G A + S + ++ ++++++G+CPQ + FD LT RE+L+++ +++GI K+ +
Sbjct: 448 EGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE 507
Query: 2167 VKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLW 2226
VK + +L++ D A SGG KRKL+ IA++G P + LDEPT G+DP +R +W
Sbjct: 508 VKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVW 567
Query: 2227 NLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVR 2286
+L+ + K R ++ ++ M+E + L R + NG+L+C GS LK ++G GY +++
Sbjct: 568 SLLKE-HKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLH 626
Query: 2287 TKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKMEQVSGVLGIE 2345
+ + ++ P+A L K+ Y L E + ++S +++ S GI
Sbjct: 627 RNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSD-QGIR 685
Query: 2346 DYSVSQTTLDNVFVNFAKKQS 2366
+Y+VS T+L+ VF+N K +
Sbjct: 686 NYAVSVTSLNEVFLNLEGKSA 706
Score = 170 bits (430), Expect = 2e-41
Identities = 117/381 (30%), Positives = 194/381 (50%), Gaps = 46/381 (12%)
Query: 962 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKK---------LALNKLS 1012
E+ QA +++ +EEEP V+ L K Y + KK +A+ +S
Sbjct: 1172 EDVQAERVQAANALTAPNLEEEP-----VITASCLHKEYYETKKSCFSTRKKKIAIRNVS 1226
Query: 1013 LNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGH--DIRTEMDEIRKNLGMC 1070
+ + +V+ LGHNGAGK+T++ ++TG PT+G + G +R + D K LG C
Sbjct: 1227 FCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYC 1286
Query: 1071 PQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKR 1130
PQ N L+ +LT++EHL Y+ +K + +E+ + +++E L+L + + V+TLS G+KR
Sbjct: 1287 PQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKR 1346
Query: 1131 KLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI---LKYKPGRTILLSTHHMDEADL 1187
KL ++ +G ++LDEP G+DP ++ +W ++ +K K R LL+TH+M EA+
Sbjct: 1347 KLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKE-RGTLLTTHYMSEAEA 1405
Query: 1188 LGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTL-VKRPAEPGGPQEPGLASSPPGRAPL 1246
+ DR+A++ G L+C GS LK +G Y L + +K P Q L + P
Sbjct: 1406 VCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPT-----QVEALHTEILKLFPQ 1460
Query: 1247 SSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLS 1306
++ E S+ ++Y LP E R F LE +L
Sbjct: 1461 AAWQERY------------------SSLMAYKLPVEDVH--PLSRAFFKLEAMKQTFNLE 1500
Query: 1307 SFGLMDTTLEEVFLKVSEEDQ 1327
+ L TLE+VFL++ +E +
Sbjct: 1501 EYSLSQATLEQVFLELCKEQE 1521
Score = 34.3 bits (77), Expect = 1.5
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 16/117 (13%)
Query: 1808 ASFVVFL---VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDL 1864
+SF+ F VA + K K L V G +WL+ W L Y+ C + I+ +F
Sbjct: 145 SSFIYFASLNVARERGKFKKLMTVMGLRESAFWLS---WG-LTYI----CFIFIMSIFMA 196
Query: 1865 PAYTS-----PTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIG 1916
TS T F + +L+ LYG S+ + + S P A + + +F G
Sbjct: 197 LVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWG 253
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 279 bits (713), Expect = 3e-74
Identities = 207/707 (29%), Positives = 362/707 (51%), Gaps = 89/707 (12%)
Query: 655 YFLYGFVWIQDMMERAIIDTFVGHDVVEP---GSYVQMFPYPCYTRD------DFLFVIE 705
Y+ GFV +Q + AII+ H V+E + + M P T++ LF +
Sbjct: 170 YWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLL 229
Query: 706 HMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFI--TGFVQLSI 763
H PL VY +++ V ++ + K +MK MGL ++ W++W + GF+ + I
Sbjct: 230 HFSPL------VYFISLN----VTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFI-I 278
Query: 764 SVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYF 823
S+ +T I+ + Q+++ + ++I++ +Y ++ + FL+SVL KA L + ++ F
Sbjct: 279 SIF-VTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTN----LVVF 333
Query: 824 LSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQ 883
L + + + V ++++ + + I ++ S AF G + ++ + +
Sbjct: 334 L--LTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTG-----MIQIIKLDYNLNGVIF 386
Query: 884 SPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRT 943
GD + ++ +ML++D ++Y +L Y + + P YG R Y PL ++L S
Sbjct: 387 PDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILP--YGDERH-YSPL---FFLNSSSC 440
Query: 944 EAWEWSWPWARTPRLSVMEEDQACAMESRRFE----ETRGMEEEPTHLPLVVCVDKLTKV 999
+ RT + +E A FE E +G E + + + K
Sbjct: 441 ------FQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKE--------AIRIRNVKKE 486
Query: 1000 YK--DDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIR 1057
YK K AL L ++YE Q+ + LGH+GAGK++ ++IL GL PT GS TIY ++
Sbjct: 487 YKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLS 546
Query: 1058 T--EMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSN 1115
+++EIRK G+CPQ NV FD LTV+E+L ++++K + +E+ +E+ +++ +L++ N
Sbjct: 547 EMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQN 606
Query: 1116 KRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTI 1175
+ +L + LS G KRKL+ I +G + ++LDEPT G+DP++R +W L+ + + I
Sbjct: 607 IQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVI 666
Query: 1176 LLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPG 1235
L ST MDEAD+L DR I+S+G+LKC GS +FLK +G GY L+L +
Sbjct: 667 LFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRN----------- 715
Query: 1236 LASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQH 1295
C+ Q++ FI H+ L ++ +L Y LP E + F LF
Sbjct: 716 -----------EICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLE--RTNTFPDLFSD 762
Query: 1296 LERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKD 1342
L++ D ++ + + +TL EVF+K+ E QS + + E +D
Sbjct: 763 LDKCSDQ-GVTGYDISMSTLNEVFMKL--EGQSTIEQDFEQVEMIRD 806
Score = 216 bits (549), Expect = 3e-55
Identities = 179/669 (26%), Positives = 311/669 (46%), Gaps = 72/669 (10%)
Query: 1730 VFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQ 1789
V N K H P +N ++N +L+ T H + S+ L ++
Sbjct: 964 VVCNTKRLHCFPILMNIISNGLLQM-------------FNHTQH-IRIESSPFPLSHIGL 1009
Query: 1790 GTDVVI-AIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNY 1848
T + + F+ + + + + +++ AK ++SG YW
Sbjct: 1010 WTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQA------- 1062
Query: 1849 LVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFL 1908
LV + ++IL + L Y + + S + +TP Y AS F + +++F
Sbjct: 1063 LVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTP-GYAASLVFFIYMISFIFR 1121
Query: 1909 -----IVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAY 1963
+ F A+ F + L H DL + L + ++ P+Y L + +
Sbjct: 1122 KRRKNSGLWSFYFFFASTIMFSITLINHF-DLSI----LITTMVLVPSYTL------LGF 1170
Query: 1964 NEYIN----EYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRR-- 2017
++ E+Y + + + S ++ + + V + + C +R+
Sbjct: 1171 KTFLEVRDQEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDP 1230
Query: 2018 -----PQRM---PVSTKPVEDDVDVASERQRVLRGDA-----DNDMVKIENLTKVYKSRK 2064
PQ P +P+++D D+ +ER R + ++ L K Y +K
Sbjct: 1231 VFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQK 1290
Query: 2065 IG------RILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHS 2118
+ +A + V+ GE GLLG NGAGK+S+ +M++G T GE + G S
Sbjct: 1291 KSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCS 1350
Query: 2119 VLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTK 2178
V LGYCPQ + L+ LT REHL++Y ++G+ D + + +L +
Sbjct: 1351 ------SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHE 1404
Query: 2179 YADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK-TGR 2237
+ P + G RKL ++L+G + LDEP+TG+DP ++ +W I ++K T R
Sbjct: 1405 QLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTER 1464
Query: 2238 SVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVV 2297
V+LT+H++ E EALC R+AIMV+GRLRC+GSIQHLKN+ G Y++ ++ K + V V
Sbjct: 1465 GVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVH 1524
Query: 2298 RFFNRNFPEAMLKERHHTKVQYQLK-SEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDN 2356
+ FP+A +ER+ + + Y+L ++ L+Q F K+E V +E+YS+SQ TL+
Sbjct: 1525 TEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEK 1584
Query: 2357 VFVNFAKKQ 2365
VF+ +K+Q
Sbjct: 1585 VFLELSKEQ 1593
Score = 188 bits (478), Expect = 5e-47
Identities = 151/632 (23%), Positives = 290/632 (45%), Gaps = 30/632 (4%)
Query: 1762 NPAAYGITVTNHPMNKTSASLS------LDYLLQGTDVVIAIFIIVAMSFVPASFVVFL- 1814
N A IT TNHP+ + S++ L ++ + + + F P + + L
Sbjct: 183 NTAIIEIT-TNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLN 241
Query: 1815 VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFP 1874
V ++ K+K+L + G +WL+ W ++ + + + T F
Sbjct: 242 VTKERKKSKNLMKMMGLQDSAFWLS---WGLIYAGFIFIISIFVTIIITFTQIIVMTGFM 298
Query: 1875 AVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKD 1934
+ LF LYG S+ +++ S + + + ++ LF G + +
Sbjct: 299 VIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWI 358
Query: 1935 LKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLV 1994
L + + + + +I L + L + + + + Y I F + D + L+
Sbjct: 359 LNICSPFAFTTGMI-QIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLL----DGLIYLLL 413
Query: 1995 AMAVEGVVGF----LLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADN-- 2048
A+ + ++ + + + N Q + K +E ++D A
Sbjct: 414 ALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQ 473
Query: 2049 --DMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDES 2106
+ ++I N+ K YK K G++ A+ L + G+ +LG +GAGK+S +L G
Sbjct: 474 GKEAIRIRNVKKEYKG-KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSV 532
Query: 2107 TTGGEAFVNGHSV--LKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEA 2164
T G + ++ +++L ++++ G CPQ + FD LT +E+L L+ +++GI K+
Sbjct: 533 PTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVE 592
Query: 2165 RVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRF 2224
+ V+ L +L++ D A S G KRKL+ I ++G P + LDEPTTG+DP +R
Sbjct: 593 QEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 2225 LWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMIT 2284
+W+L+ + + ++ ++ SM+E + L R IM NGRL+C GS LK R+G GY ++
Sbjct: 653 VWSLLRER-RADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLS 711
Query: 2285 VRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLG 2343
+ + + + F + P+A LK + K+ Y L E + +FS +++ S G
Sbjct: 712 LHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSD-QG 770
Query: 2344 IEDYSVSQTTLDNVFVNFAKKQSDNLEQQETE 2375
+ Y +S +TL+ VF+ + + + ++ E
Sbjct: 771 VTGYDISMSTLNEVFMKLEGQSTIEQDFEQVE 802
Score = 154 bits (388), Expect = 1e-36
Identities = 104/353 (29%), Positives = 176/353 (49%), Gaps = 34/353 (9%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K KK+A +S + E +++ LG NGAGK++++ +++G+ PT+G + G
Sbjct: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------C 1349
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1120
+ +LG CPQ NVL+ LT+ EHL Y+ +K + + + R + +++ +L + +
Sbjct: 1350 SSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVP 1409
Query: 1121 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI--LKYKPGRTILLS 1178
VQ L+ G+ RKL ++ +G S ++LDEP+ G+DP ++ +W I + R +LL+
Sbjct: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
Query: 1179 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1238
TH++ EA+ L DR+AI+ G+L+C GS LK G Y L L + +
Sbjct: 1470 THNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILK 1529
Query: 1239 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1298
P A S L L+Y LP A + F LE
Sbjct: 1530 LFPQAAGQERYSSL----------------------LTYKLP--VADVYPLSQTFHKLEA 1565
Query: 1299 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKES-RKDVLPGAEGP 1350
+L + L TLE+VFL++S+E Q + N + ++ + R +LP ++ P
Sbjct: 1566 VKHNFNLEEYSLSQCTLEKVFLELSKE-QEVGNFDEEIDTTMRWKLLPHSDEP 1617
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 252 bits (644), Expect = 3e-66
Identities = 234/863 (27%), Positives = 388/863 (44%), Gaps = 146/863 (16%)
Query: 501 RSFLEQGRLQQH--LRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQL 558
++FL++ R+++ + WL + L L+ + +++ L D L ++
Sbjct: 18 KNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLLTMD----------LGRV 67
Query: 559 DTIDNAACGWI---------QFMSKVSVDIFK------GFPDEESIVNYTLNQAYQDNVT 603
DT + + + Q M+KV+ F G PDEESI +T N +
Sbjct: 68 DTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYPEEIVRV 127
Query: 604 VFASVIFQTRK---DGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGF 660
F + K +P +K +++ +TNE Y ++ GF
Sbjct: 128 TFTNTYSYHLKFLLGHGMPAKKEHK--DHTAHCYETNE--DVYCEVS------VFWKEGF 177
Query: 661 VWIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSV 720
V +Q + AII+ H V+E V ++ VI + +IS+ +
Sbjct: 178 VALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFI 237
Query: 721 AMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMH 780
++ E++ R+K +M MGL ++ W++W + + I L +++ Q ++
Sbjct: 238 YYASVNVTRERK-RMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIIL 296
Query: 781 SHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 840
S ++++ +Y ++ + FL+S+L K+ L G++ FL V + + H
Sbjct: 297 SGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLT----GLVVFLLTVFWGCLGFTSLYRH 352
Query: 841 DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVT-M 899
+ A + I SL+S AF LG + + + F P D NL++A M
Sbjct: 353 --LPASLEWILSLLSPFAFMLGMAQLLHLD---YDLNSNAF---PHPSDGSNLIVATNFM 404
Query: 900 LMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLS 959
L D +Y L Y E + P YG RP F L+ S+W + +T+
Sbjct: 405 LAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTD--------------H 450
Query: 960 VMEEDQACAMESRRFEETRGMEEEPTHL--PLVVCVDKLTKVY--KDDKKLALNKLSLNL 1015
V ED+ A S F ++ E+ P + + +TK Y K DK AL L ++
Sbjct: 451 VALEDEMDADPS--FHDS--FEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDI 506
Query: 1016 YENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDI--RTEMDEIRKNLGMCPQH 1073
YE Q+ + LGH+GAGK+T ++IL+GL PT GS TIY + + +++ + K G+CPQ
Sbjct: 507 YEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQS 566
Query: 1074 NVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLS 1133
NV FD LTV E+L ++++K + +E+ +E+
Sbjct: 567 NVQFDFLTVRENLRLFAKIKGILPQEVDKEI----------------------------- 597
Query: 1134 VAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIA 1193
+LDEPTAG+DP++R +W+L+ + K R IL ST MDEAD+L DR
Sbjct: 598 -----------FLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKV 646
Query: 1194 IISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQ 1253
+S GKLKC GS LFLK +G GY L+L C E
Sbjct: 647 FLSQGKLKCAGSSLFLKKKWGIGYHLSLQLN----------------------EICVEEN 684
Query: 1254 VSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDT 1313
++ +++H+ L + + +L Y LP E K F L++ L+ S L + ++G+ T
Sbjct: 685 ITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNK--FPELYKDLD-SYPDLGIENYGVSMT 741
Query: 1314 TLEEVFLKVSEEDQSLENSEADV 1336
TL EVFLK+ E +S N E+D+
Sbjct: 742 TLNEVFLKL--EGKSTIN-ESDI 761
Score = 239 bits (609), Expect = 3e-62
Identities = 188/623 (30%), Positives = 304/623 (48%), Gaps = 82/623 (13%)
Query: 1797 IFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCV 1856
+F +V S P + + + +A+ +SG +P YW + D+ Y +
Sbjct: 986 MFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFL------ 1039
Query: 1857 IILFVFDLPAYTSPTNFPAVLSLFLL---------YGWSITPIMYPASFWFEVP---SSA 1904
+ +F++ L +Y S NF +L + Y +S+ + Y SF F S
Sbjct: 1040 VFVFIY-LMSYIS--NFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGI 1096
Query: 1905 YVFLI-VINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLME--M 1961
+ F V+ +F +VA F +FE D FLI P +G + +
Sbjct: 1097 WSFCFYVVTVF-----SVAGFAFSIFESDIPFIFT-------FLIPPATMIGCLFLSSHL 1144
Query: 1962 AYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMC-QYNFLRR--- 2017
++ +E + F PF I+ FL T+ C ++ F ++
Sbjct: 1145 LFSSLFSEERMDVQPFLVFLIPFLHFII--------------FLFTLRCLEWKFGKKSMR 1190
Query: 2018 --------PQRMPVSTKPVE---DDVDVASERQRVLRG----DADNDMVKIEN-LTKVYK 2061
P+ V P E +D DV ER R + D V I + L K Y
Sbjct: 1191 KDPFFRISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYA 1250
Query: 2062 SRKIGRI------LAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVN 2115
++ G +A + VR GE GLLG NGAGK+++ K++TGD T G+ +
Sbjct: 1251 GKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLK 1310
Query: 2116 GHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLE 2175
G L + LGYCPQ +AL+ LT R+HL++Y ++G+ D + ++ L+
Sbjct: 1311 GSGGGDAL----EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALK 1366
Query: 2176 LTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK- 2234
L P T S G KRKL ++++G P+ + LDEP+TGMDP+ ++ +W I +
Sbjct: 1367 LQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRN 1426
Query: 2235 TGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVK 2294
T R +LT+H M E EA+C R+AIMV+GRLRC+GSIQHLK++FG Y++ ++ K+ V+
Sbjct: 1427 TERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVE 1486
Query: 2295 DVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKMEQVSGVLGIEDYSVSQTT 2353
+ R FP+A +ER+ + + Y+L E + LAQ F K+E+V +E+YS+SQ+T
Sbjct: 1487 PLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQST 1546
Query: 2354 LDNVFVNFAKKQSDNLEQQETEP 2376
L+ VF+ +K+Q +++ +P
Sbjct: 1547 LEQVFLELSKEQELGDFEEDFDP 1569
Score = 162 bits (410), Expect = 4e-39
Identities = 114/352 (32%), Positives = 182/352 (51%), Gaps = 31/352 (8%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K K+A +S + + +V+ LGHNGAGK+T++ ++TG PT+G + G +
Sbjct: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGG 1314
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1120
+ + LG CPQ N L+ LTV +HL Y+ +K + + + + ++++ L+L ++ S
Sbjct: 1315 GDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSP 1374
Query: 1121 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLS 1178
V+TLS G+KRKL ++ +G ++LDEP+ G+DP ++ +W I R LL+
Sbjct: 1375 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT 1434
Query: 1179 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1238
TH+M EA+ + DR+AI+ G+L+C GS LK +G Y L + + LA
Sbjct: 1435 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM----------KVKNLAQ 1484
Query: 1239 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1298
P A + Q R+ S L+V Y LP E + A + F LE+
Sbjct: 1485 VEPLHAEILRL----FPQAARQERYSSLMV--------YKLPVEDVQPLA--QAFFKLEK 1530
Query: 1299 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGP 1350
+ L + L +TLE+VFL++S+E Q L + E D S K L E P
Sbjct: 1531 VKQSFDLEEYSLSQSTLEQVFLELSKE-QELGDFEEDFDPSVKWKLLPQEEP 1581
Score = 137 bits (344), Expect = 2e-31
Identities = 151/634 (23%), Positives = 266/634 (41%), Gaps = 88/634 (13%)
Query: 1762 NPAAYGITVTNHP-----MNKTSASLSLDYLLQGTDVVIAIFIIVAM-SFVPASFVVFL- 1814
N A IT TNH M+ T ++ + + + V+ +++ + SF +SF+ +
Sbjct: 185 NAAIIEIT-TNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISF--SSFIYYAS 241
Query: 1815 --VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTN 1872
V + + K L + G +WL+ W +L + + V + +
Sbjct: 242 VNVTRERKRMKALMTMMGLRDSAFWLS---WGLLYAGFIFIMALFLALVIRSTQFIILSG 298
Query: 1873 FPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHD 1932
F V SLFLLYG S+ + + S + + + ++ +F G + L+ H
Sbjct: 299 FMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTS-----LYRH- 352
Query: 1933 KDLKVVNSYLKSCFLIFPNYNLGHG-LMEMAYNEYINEY-YAKIGQFDKMKSPFEWDIVT 1990
L ++ S F + LG L+ + Y+ N + + G + + F T
Sbjct: 353 --LPASLEWILSLLSPFA-FMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDT 409
Query: 1991 RGLVAMAVEGVVGFLLTIMCQYNFLRRP----------QRMPVSTKPVEDDVDVA----S 2036
+A+A+ F + +Y R P Q +ED++D
Sbjct: 410 CLYLALAIY----FEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHD 465
Query: 2037 ERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTS 2096
++ + ++I N+TK YK K +I A+ L + G+ +LG +GAGK++
Sbjct: 466 SFEQAPPEFQGKEAIRIRNVTKEYKG-KPDKIEALKDLVFDIYEGQITAILGHSGAGKST 524
Query: 2097 TFKMLTGDESTTGGEAFV--NGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTR 2154
+L+G T G + N S + +L + + G CPQ + FD LT RE+L+L+ +
Sbjct: 525 LLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAK 584
Query: 2155 LRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPT 2214
++GI L + DK LDEPT
Sbjct: 585 IKGI-----------------LPQEVDKE-----------------------IFLLDEPT 604
Query: 2215 TGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLK 2274
G+DP +R +WNL+ + KT R ++ ++ M+E + L R + G+L+C GS LK
Sbjct: 605 AGLDPFSRHQVWNLLKER-KTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLK 663
Query: 2275 NRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSK 2334
++G GY ++++ +++ ++ P+A L + K+ Y L E + K
Sbjct: 664 KKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYK 723
Query: 2335 MEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2368
LGIE+Y VS TTL+ VF+ K + N
Sbjct: 724 DLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTIN 757
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 165 bits (418), Expect = 4e-40
Identities = 81/163 (49%), Positives = 113/163 (69%)
Query: 2143 LTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALI 2202
+TA+E + +Y R+ G+S V L LEL +A + TYS GNKR+LSTAIAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2203 GYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNG 2262
G + IFLDEP+TGMDP ARR LWN++ ++G+++V+TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2263 RLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFP 2305
+ CLGS QHLK++FG+ Y++ V+ K+ ++D + FP
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 108 bits (271), Expect = 5e-23
Identities = 55/141 (39%), Positives = 88/141 (62%), Gaps = 1/141 (0%)
Query: 1080 LTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFV 1139
+T +E + Y+R+ +++ +I ++K + LEL + L+ T S G KR+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1140 GGSRAIILDEPTAGVDPYARRAIWDLILKYK-PGRTILLSTHHMDEADLLGDRIAIISHG 1198
G S I LDEP+ G+DP ARR +W+++ K + G+ I++++H M+E D L +AI+ G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1199 KLKCCGSPLFLKGTYGDGYRL 1219
K C GSP LK +G+ Y L
Sbjct: 121 KFTCLGSPQHLKSKFGNIYIL 141
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 165 bits (418), Expect = 4e-40
Identities = 81/163 (49%), Positives = 113/163 (69%)
Query: 2143 LTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALI 2202
+TA+E + +Y R+ G+S V L LEL +A + TYS GNKR+LSTAIAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2203 GYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNG 2262
G + IFLDEP+TGMDP ARR LWN++ ++G+++V+TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2263 RLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFP 2305
+ CLGS QHLK++FG+ Y++ V+ K+ ++D + FP
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 108 bits (271), Expect = 5e-23
Identities = 55/141 (39%), Positives = 88/141 (62%), Gaps = 1/141 (0%)
Query: 1080 LTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFV 1139
+T +E + Y+R+ +++ +I ++K + LEL + L+ T S G KR+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1140 GGSRAIILDEPTAGVDPYARRAIWDLILKYK-PGRTILLSTHHMDEADLLGDRIAIISHG 1198
G S I LDEP+ G+DP ARR +W+++ K + G+ I++++H M+E D L +AI+ G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1199 KLKCCGSPLFLKGTYGDGYRL 1219
K C GSP LK +G+ Y L
Sbjct: 121 KFTCLGSPQHLKSKFGNIYIL 141
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 165 bits (418), Expect = 4e-40
Identities = 81/163 (49%), Positives = 113/163 (69%)
Query: 2143 LTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALI 2202
+TA+E + +Y R+ G+S V L LEL +A + TYS GNKR+LSTAIAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2203 GYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNG 2262
G + IFLDEP+TGMDP ARR LWN++ ++G+++V+TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2263 RLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFP 2305
+ CLGS QHLK++FG+ Y++ V+ K+ ++D + FP
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 108 bits (271), Expect = 5e-23
Identities = 55/141 (39%), Positives = 88/141 (62%), Gaps = 1/141 (0%)
Query: 1080 LTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFV 1139
+T +E + Y+R+ +++ +I ++K + LEL + L+ T S G KR+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1140 GGSRAIILDEPTAGVDPYARRAIWDLILKYK-PGRTILLSTHHMDEADLLGDRIAIISHG 1198
G S I LDEP+ G+DP ARR +W+++ K + G+ I++++H M+E D L +AI+ G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1199 KLKCCGSPLFLKGTYGDGYRL 1219
K C GSP LK +G+ Y L
Sbjct: 121 KFTCLGSPQHLKSKFGNIYIL 141
>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sapiens]
Length = 651
Score = 89.4 bits (220), Expect = 4e-17
Identities = 72/219 (32%), Positives = 107/219 (48%), Gaps = 16/219 (7%)
Query: 2076 LGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTG---GEAFVNGHSVLKELLQVQQSLGY 2132
L V G+ +LG +G+GKT+ ++G G GE +VNG ++ +E Q Q Y
Sbjct: 74 LYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQDCFSY 131
Query: 2133 CPQCDALFDELTAREHLQLYTRLRGISWKDEA---RVVKWALEKLELTKYADKPAGTYS- 2188
Q D L LT RE L YT L I + + V+ + +L L+ AD+ G YS
Sbjct: 132 VLQSDTLLSSLTVRETLH-YTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSL 190
Query: 2189 ----GGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244
G +R++S A L+ P + DEPTTG+D + L+++L + R VVLT H
Sbjct: 191 GGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIH 250
Query: 2245 S-MEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGD-GY 2281
E L ++AI+ G L G+ + + F D GY
Sbjct: 251 QPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
Score = 75.5 bits (184), Expect = 6e-13
Identities = 59/223 (26%), Positives = 108/223 (48%), Gaps = 15/223 (6%)
Query: 1008 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTS---GSATIYGHDIRTEMDEIR 1064
L +SL + Q++ LG +G+GKTT + ++G G + G +R E + +
Sbjct: 69 LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQ 126
Query: 1065 KNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQE--EIRREMDKMIEDLELSNKRHSLVQ 1122
Q + L LTV E L + + L +++++ ++ +L LS+ L+
Sbjct: 127 DCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIG 186
Query: 1123 T-----LSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILL 1177
+S G +R++S+A + + ++ DEPT G+D I L+++ I++
Sbjct: 187 NYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVV 246
Query: 1178 STHHMDEADL--LGDRIAIISHGKLKCCGSPLFLKGTYGD-GY 1217
T H ++L L D+IAI+S G+L CG+P + + D GY
Sbjct: 247 LTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 85.9 bits (211), Expect = 4e-16
Identities = 61/217 (28%), Positives = 112/217 (51%), Gaps = 13/217 (5%)
Query: 1008 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDI-RTEMDEIRKN 1066
L LSL + + Q ++ +G +G GK+T + +L + P +G + G +I R + +R +
Sbjct: 1053 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAH 1112
Query: 1067 LGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRR-----EMDKMIEDL--ELSNKRHS 1119
LG+ Q +LFD ++ E++ + + ++QEEI R + IE L + S K
Sbjct: 1113 LGIVSQEPILFD-CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGD 1171
Query: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
LSGG K+++++A A V ++LDE T+ +D + + + + + K + GRT ++
Sbjct: 1172 KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIA 1231
Query: 1180 HHMDEADLLGDRIAIISHGKLKCCGSP---LFLKGTY 1213
H + D I + +G++K G+ L KG Y
Sbjct: 1232 HRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQKGIY 1267
Score = 82.0 bits (201), Expect = 6e-15
Identities = 53/181 (29%), Positives = 101/181 (55%), Gaps = 7/181 (3%)
Query: 1008 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT-EMDEIRKN 1066
L L+L + Q V+ +G++G GK+TT+ ++ L+ PT G ++ G DIRT + +R+
Sbjct: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
Query: 1067 LGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQ-EEIRREMDKMIEDLELSNKRHSLV---- 1121
+G+ Q VLF T+ E++ + +M + E+ +E + ++L +K +LV
Sbjct: 470 IGVVSQEPVLF-ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERG 528
Query: 1122 QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHH 1181
LSGG K+++++A A V + ++LDE T+ +D + + + K + GRT ++ H
Sbjct: 529 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHR 588
Query: 1182 M 1182
+
Sbjct: 589 L 589
Score = 65.5 bits (158), Expect = 6e-10
Identities = 56/210 (26%), Positives = 102/210 (48%), Gaps = 15/210 (7%)
Query: 2074 LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQ-VQQSLGY 2132
L L V+ G+ L+G +G GK++ ++L G+ ++G + + +Q ++ LG
Sbjct: 1056 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGI 1115
Query: 2133 CPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWA--------LEKLELTKYADKPA 2184
Q LFD + E++ R +S ++ R K A L TK DK
Sbjct: 1116 VSQEPILFD-CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDK-- 1172
Query: 2185 GTY-SGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTS 2243
GT SGG K++++ A AL+ P + LDE T+ +D ++ + + LD + GR+ ++ +
Sbjct: 1173 GTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE-ALDKAREGRTCIVIA 1231
Query: 2244 HSMEECEALCTRLAIMVNGRLRCLGSIQHL 2273
H + + + + NGR++ G+ Q L
Sbjct: 1232 HRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1260
Score = 55.8 bits (133), Expect = 5e-07
Identities = 56/232 (24%), Positives = 111/232 (47%), Gaps = 19/232 (8%)
Query: 2023 VSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGE 2082
+ KP D + + ++G+ ++ N+ Y SRK +IL L L V+ G+
Sbjct: 369 IDNKPSIDSYSKSGHKPDNIKGN-----LEFRNVHFSYPSRKEVKILK--GLNLKVQSGQ 421
Query: 2083 CFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQ-VQQSLGYCPQCDALFD 2141
L+G +G GK++T +++ T G V+G + ++ +++ +G Q LF
Sbjct: 422 TVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF- 480
Query: 2142 ELTAREHLQLYTRLRGISWKDEARVVKWA-----LEKL--ELTKYADKPAGTYSGGNKRK 2194
T E+++ Y R ++ + + VK A + KL + + SGG K++
Sbjct: 481 ATTIAENIR-YGR-ENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQR 538
Query: 2195 LSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSM 2246
++ A AL+ P + LDE T+ +D ++ + + LD + GR+ ++ +H +
Sbjct: 539 IAIARALVRNPKILLLDEATSALDTESEAVV-QVALDKARKGRTTIVIAHRL 589
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 82.4 bits (202), Expect = 5e-15
Identities = 58/202 (28%), Positives = 107/202 (52%), Gaps = 10/202 (4%)
Query: 1008 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT-EMDEIRKN 1066
L LSL++ + V+F+G +G GK+T++ +L L+ P G G D + + +R
Sbjct: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647
Query: 1067 LGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRR-----EMDKMIEDL-ELSNKRHSL 1120
+ + PQ VLF+ ++ E++ + + + +EI+ + IE L E N + L
Sbjct: 648 IAIVPQEPVLFN-CSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 706
Query: 1121 VQT-LSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
LSGG K++L++A A + + ++LDE T+ +D + + + + K + GRT L+ T
Sbjct: 707 KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVT 766
Query: 1180 HHMDEADLLGDRIAIISHGKLK 1201
H + A D I ++ +GK+K
Sbjct: 767 HRL-SAIQNADLIVVLHNGKIK 787
Score = 54.7 bits (130), Expect = 1e-06
Identities = 56/236 (23%), Positives = 106/236 (44%), Gaps = 32/236 (13%)
Query: 2074 LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQ-VQQSLGY 2132
L L + G+ +G +G GK+++ ++L G+ +G + +Q ++ +
Sbjct: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 650
Query: 2133 CPQCDALFDELTAREHLQLYTRLRGISWKDEARVV-----KWALEKLELTKYADKPAGTY 2187
PQ LF+ A I++ D +RVV K A + + + Y
Sbjct: 651 VPQEPVLFNCSIAEN----------IAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
Query: 2188 -----------SGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTG 2236
SGG K++L+ A AL+ P + LDE T+ +D + + + + LD +TG
Sbjct: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQH-ALDKARTG 759
Query: 2237 RSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQH-LKNRFGDGYMITVRTKSSQ 2291
R+ ++ +H + + + ++ NG+++ G+ Q L+NR D Y V +S Q
Sbjct: 760 RTCLVVTHRLSAIQN-ADLIVVLHNGKIKEQGTHQELLRNR--DIYFKLVNAQSVQ 812
Score = 52.4 bits (124), Expect = 5e-06
Identities = 45/173 (26%), Positives = 76/173 (43%), Gaps = 6/173 (3%)
Query: 1054 HDIRT-EMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLE 1112
+DIR + R ++G+ Q VLF + + E RE + +E
Sbjct: 5 NDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIME 64
Query: 1113 LSNKRHSLV----QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK 1168
NK ++LV +SGG K+++++A A V + +ILDE T+ +D ++ A+ + K
Sbjct: 65 FPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEK 124
Query: 1169 YKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTL 1221
GRT ++ H + D I + G L G+ L G Y L +
Sbjct: 125 ASKGRTTIVVAHRLSTI-RSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM 176
Score = 37.7 bits (86), Expect = 0.14
Identities = 26/107 (24%), Positives = 53/107 (49%), Gaps = 6/107 (5%)
Query: 2188 SGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSME 2247
SGG K++++ A AL+ P + LDE T+ +D +++ + L+ GR+ ++ +H +
Sbjct: 81 SGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV-QAALEKASKGRTTIVVAHRLS 139
Query: 2248 ECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVK 2294
+ + + +G L G+ L + G Y + + SQ +K
Sbjct: 140 TIRS-ADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM----SQDIK 181
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 80.9 bits (198), Expect = 1e-14
Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 6/167 (3%)
Query: 2081 GECFGLLGVNGAGKTSTFKMLTGDEST-TGGEAFVNGHSVLKELLQVQQSLGYCPQCDAL 2139
GE ++G +GAGK++ +L G T G +NG + ++L ++ Y Q D L
Sbjct: 108 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 165
Query: 2140 FDELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLST 2197
LT +E + + L+ + KDE R +VK L L L A+ G+ SGG +++L+
Sbjct: 166 LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 224
Query: 2198 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244
A+ L+ P +F DEPT+G+D + + +L+ L + GRS++ T H
Sbjct: 225 ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 271
Score = 79.3 bits (194), Expect = 4e-14
Identities = 57/202 (28%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K K L +S ++V+ +G +GAGK+T M+IL G + T + + + ++
Sbjct: 91 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 149
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK-MIEDLELSNKRHS 1119
RK Q ++L LTV+E + + LK ++E RREM K ++ L L + ++
Sbjct: 150 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 209
Query: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
+LSGG +++L++A+ V + DEPT+G+D + + L+ G ++ T
Sbjct: 210 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 269
Query: 1180 HHMDEADL--LGDRIAIISHGK 1199
H A L L D++ ++S G+
Sbjct: 270 IHQPSAKLFELFDQLYVLSQGQ 291
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 80.9 bits (198), Expect = 1e-14
Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 6/167 (3%)
Query: 2081 GECFGLLGVNGAGKTSTFKMLTGDEST-TGGEAFVNGHSVLKELLQVQQSLGYCPQCDAL 2139
GE ++G +GAGK++ +L G T G +NG + ++L ++ Y Q D L
Sbjct: 89 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 146
Query: 2140 FDELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLST 2197
LT +E + + L+ + KDE R +VK L L L A+ G+ SGG +++L+
Sbjct: 147 LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 205
Query: 2198 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244
A+ L+ P +F DEPT+G+D + + +L+ L + GRS++ T H
Sbjct: 206 ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 252
Score = 79.3 bits (194), Expect = 4e-14
Identities = 57/202 (28%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K K L +S ++V+ +G +GAGK+T M+IL G + T + + + ++
Sbjct: 72 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 130
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK-MIEDLELSNKRHS 1119
RK Q ++L LTV+E + + LK ++E RREM K ++ L L + ++
Sbjct: 131 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 190
Query: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
+LSGG +++L++A+ V + DEPT+G+D + + L+ G ++ T
Sbjct: 191 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 250
Query: 1180 HHMDEADL--LGDRIAIISHGK 1199
H A L L D++ ++S G+
Sbjct: 251 IHQPSAKLFELFDQLYVLSQGQ 272
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 80.9 bits (198), Expect = 1e-14
Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 6/167 (3%)
Query: 2081 GECFGLLGVNGAGKTSTFKMLTGDEST-TGGEAFVNGHSVLKELLQVQQSLGYCPQCDAL 2139
GE ++G +GAGK++ +L G T G +NG + ++L ++ Y Q D L
Sbjct: 113 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 170
Query: 2140 FDELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLST 2197
LT +E + + L+ + KDE R +VK L L L A+ G+ SGG +++L+
Sbjct: 171 LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 229
Query: 2198 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244
A+ L+ P +F DEPT+G+D + + +L+ L + GRS++ T H
Sbjct: 230 ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 276
Score = 79.3 bits (194), Expect = 4e-14
Identities = 57/202 (28%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K K L +S ++V+ +G +GAGK+T M+IL G + T + + + ++
Sbjct: 96 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 154
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK-MIEDLELSNKRHS 1119
RK Q ++L LTV+E + + LK ++E RREM K ++ L L + ++
Sbjct: 155 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 214
Query: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
+LSGG +++L++A+ V + DEPT+G+D + + L+ G ++ T
Sbjct: 215 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 274
Query: 1180 HHMDEADL--LGDRIAIISHGK 1199
H A L L D++ ++S G+
Sbjct: 275 IHQPSAKLFELFDQLYVLSQGQ 296
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 80.9 bits (198), Expect = 1e-14
Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 6/167 (3%)
Query: 2081 GECFGLLGVNGAGKTSTFKMLTGDEST-TGGEAFVNGHSVLKELLQVQQSLGYCPQCDAL 2139
GE ++G +GAGK++ +L G T G +NG + ++L ++ Y Q D L
Sbjct: 122 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 179
Query: 2140 FDELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLST 2197
LT +E + + L+ + KDE R +VK L L L A+ G+ SGG +++L+
Sbjct: 180 LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 238
Query: 2198 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244
A+ L+ P +F DEPT+G+D + + +L+ L + GRS++ T H
Sbjct: 239 ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
Score = 79.3 bits (194), Expect = 4e-14
Identities = 57/202 (28%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K K L +S ++V+ +G +GAGK+T M+IL G + T + + + ++
Sbjct: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 163
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK-MIEDLELSNKRHS 1119
RK Q ++L LTV+E + + LK ++E RREM K ++ L L + ++
Sbjct: 164 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 223
Query: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
+LSGG +++L++A+ V + DEPT+G+D + + L+ G ++ T
Sbjct: 224 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 283
Query: 1180 HHMDEADL--LGDRIAIISHGK 1199
H A L L D++ ++S G+
Sbjct: 284 IHQPSAKLFELFDQLYVLSQGQ 305
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 80.9 bits (198), Expect = 1e-14
Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 6/167 (3%)
Query: 2081 GECFGLLGVNGAGKTSTFKMLTGDEST-TGGEAFVNGHSVLKELLQVQQSLGYCPQCDAL 2139
GE ++G +GAGK++ +L G T G +NG + ++L ++ Y Q D L
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 168
Query: 2140 FDELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLST 2197
LT +E + + L+ + KDE R +VK L L L A+ G+ SGG +++L+
Sbjct: 169 LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 227
Query: 2198 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244
A+ L+ P +F DEPT+G+D + + +L+ L + GRS++ T H
Sbjct: 228 ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
Score = 79.3 bits (194), Expect = 4e-14
Identities = 57/202 (28%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K K L +S ++V+ +G +GAGK+T M+IL G + T + + + ++
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 152
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK-MIEDLELSNKRHS 1119
RK Q ++L LTV+E + + LK ++E RREM K ++ L L + ++
Sbjct: 153 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 212
Query: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
+LSGG +++L++A+ V + DEPT+G+D + + L+ G ++ T
Sbjct: 213 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 272
Query: 1180 HHMDEADL--LGDRIAIISHGK 1199
H A L L D++ ++S G+
Sbjct: 273 IHQPSAKLFELFDQLYVLSQGQ 294
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 80.9 bits (198), Expect = 1e-14
Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 6/167 (3%)
Query: 2081 GECFGLLGVNGAGKTSTFKMLTGDEST-TGGEAFVNGHSVLKELLQVQQSLGYCPQCDAL 2139
GE ++G +GAGK++ +L G T G +NG + ++L ++ Y Q D L
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 168
Query: 2140 FDELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLST 2197
LT +E + + L+ + KDE R +VK L L L A+ G+ SGG +++L+
Sbjct: 169 LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 227
Query: 2198 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244
A+ L+ P +F DEPT+G+D + + +L+ L + GRS++ T H
Sbjct: 228 ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
Score = 79.3 bits (194), Expect = 4e-14
Identities = 57/202 (28%), Positives = 103/202 (50%), Gaps = 4/202 (1%)
Query: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
K K L +S ++V+ +G +GAGK+T M+IL G + T + + + ++
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 152
Query: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK-MIEDLELSNKRHS 1119
RK Q ++L LTV+E + + LK ++E RREM K ++ L L + ++
Sbjct: 153 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 212
Query: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
+LSGG +++L++A+ V + DEPT+G+D + + L+ G ++ T
Sbjct: 213 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 272
Query: 1180 HHMDEADL--LGDRIAIISHGK 1199
H A L L D++ ++S G+
Sbjct: 273 IHQPSAKLFELFDQLYVLSQGQ 294
>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
Length = 655
Score = 80.1 bits (196), Expect = 2e-14
Identities = 60/203 (29%), Positives = 94/203 (46%), Gaps = 14/203 (6%)
Query: 2086 LLGVNGAGKTSTFKMLTG--DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDEL 2143
+LG G GK+S +L D S G+ +NG + + GY Q D + L
Sbjct: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
Query: 2144 TAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADKPAGTY-----SGGNKRKL 2195
T RE+LQ LR ++ ++ + +++L L K AD GT SGG +++
Sbjct: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
Query: 2196 STAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSME-ECEALCT 2254
S + LI P+ +FLDEPTTG+D + L+ + K GR+++ + H L
Sbjct: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
Query: 2255 RLAIMVNGRLRCLGSIQHLKNRF 2277
L ++ +GRL G Q F
Sbjct: 255 SLTLLASGRLMFHGPAQEALGYF 277
Score = 70.1 bits (170), Expect = 3e-11
Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 16/219 (7%)
Query: 1022 SFLGHNGAGKTTTMSILTGLFPPT--SGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1079
+ LG G GK++ + +L P+ SG I G + N G Q +V+
Sbjct: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGT 133
Query: 1080 LTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLELSNKRHSLVQT-----LSGGMKRK 1131
LTV E+L F + L+ +M E ++++I++L L S V T +SGG +++
Sbjct: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
Query: 1132 LSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKY-KPGRTILLSTHHMDEADL-LG 1189
S+ + + + LDEPT G+D A+ L+ + K GRTI+ S H + L
Sbjct: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
Query: 1190 DRIAIISHGKLKCCGSPLFLKGTY-GDGYRLTLVKRPAE 1227
D + +++ G+L G G + GY PA+
Sbjct: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPAD 292
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 79.3 bits (194), Expect = 4e-14
Identities = 62/239 (25%), Positives = 116/239 (48%), Gaps = 11/239 (4%)
Query: 995 KLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGH 1054
K T + D ++ LN LS+++ Q ++F+G +G GK+T++ +L + P G I GH
Sbjct: 1084 KFTYPSRPDSQV-LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGH 1142
Query: 1055 DI-RTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEE-IRREMDKMIED-- 1110
D + + +R N+G+ Q VLF ++ +++ + K + E I + D
Sbjct: 1143 DSKKVNVQFLRSNIGIVSQEPVLF-ACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFV 1201
Query: 1111 LELSNKRHSLV----QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI 1166
+ L K + V LS G K+++++A A V + ++LDE T+ +D + + + +
Sbjct: 1202 MSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVAL 1261
Query: 1167 LKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRP 1225
K + GRT ++ H + D IA+++ G + G+ L G Y+L P
Sbjct: 1262 DKAREGRTCIVIAHRLSTIQ-NADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSP 1319
Score = 74.3 bits (181), Expect = 1e-12
Identities = 50/198 (25%), Positives = 103/198 (52%), Gaps = 10/198 (5%)
Query: 1008 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT-EMDEIRKN 1066
LN L++ + ++ + +G +GAGK+T + ++ + P G T+ GHDIR+ + +R
Sbjct: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
Query: 1067 LGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIR--REMDKMIEDLELSNKRHSLV--- 1121
+G+ Q VLF T+ E++ Y R + ++ ++ +E + ++L + +LV
Sbjct: 498 IGIVEQEPVLFS-TTIAENI-RYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEG 555
Query: 1122 -QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTH 1180
+SGG K+++++A A + + ++LD T+ +D + + +++ K + G TI+ H
Sbjct: 556 GGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAH 615
Query: 1181 HMDEADLLGDRIAIISHG 1198
+ D I HG
Sbjct: 616 RLSTV-RAADTIIGFEHG 632
Score = 62.8 bits (151), Expect = 4e-09
Identities = 62/279 (22%), Positives = 129/279 (46%), Gaps = 15/279 (5%)
Query: 2023 VSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGE 2082
+ KP+ D + + ++G+ ++ N+T Y SR +IL + L + ++PGE
Sbjct: 397 IDRKPIIDCMSEDGYKLDRIKGE-----IEFHNVTFHYPSRPEVKIL--NDLNMVIKPGE 449
Query: 2083 CFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQ-VQQSLGYCPQCDALFD 2141
L+G +GAGK++ +++ G V+GH + +Q ++ +G Q LF
Sbjct: 450 MTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFS 509
Query: 2142 ELTA---REHLQLYTRLRGISWKDEARVVKWALE-KLELTKYADKPAGTYSGGNKRKLST 2197
A R + T + EA + ++ + + G SGG K++++
Sbjct: 510 TTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAI 569
Query: 2198 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLA 2257
A ALI P + LD T+ +D ++ + +L I+ G +++ +H + A T +
Sbjct: 570 ARALIRNPKILLLDMATSALDNESEAMVQE-VLSKIQHGHTIISVAHRLSTVRAADTIIG 628
Query: 2258 IMVNGRLRCLGSIQHLKNRFGDGY-MITVRTKSSQSVKD 2295
+G G+ + L R G + ++T++++ +Q++ +
Sbjct: 629 -FEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNE 666
Score = 57.4 bits (137), Expect = 2e-07
Identities = 51/233 (21%), Positives = 110/233 (47%), Gaps = 15/233 (6%)
Query: 2060 YKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSV 2119
Y SR ++L + L + + PG+ +G +G GK+++ ++L G+ ++GH
Sbjct: 1087 YPSRPDSQVL--NGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDS 1144
Query: 2120 LKELLQ-VQQSLGYCPQCDALF-----DELTAREHLQLYTRLRGISWKDEARVVKWAL-- 2171
K +Q ++ ++G Q LF D + ++ + R I+ +A++ + +
Sbjct: 1145 KKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSL 1204
Query: 2172 -EKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLIL 2230
EK E S G K++++ A A++ P + LDE T+ +D ++ + + + L
Sbjct: 1205 PEKYETN--VGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVAL 1261
Query: 2231 DLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMI 2283
D + GR+ ++ +H + + +A+M G + G+ + L + G Y +
Sbjct: 1262 DKAREGRTCIVIAHRLSTIQN-ADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 78.2 bits (191), Expect = 9e-14
Identities = 54/183 (29%), Positives = 100/183 (54%), Gaps = 11/183 (6%)
Query: 1008 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT-EMDEIRKN 1066
L L+L + Q V+ +G +G GK+TT+ ++ L+ P G+ I G DIR ++ +R+
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 1067 LGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIR---REMDKMIEDLELSNKRHSLV-- 1121
+G+ Q VLF T+ E++ Y R ++ +EI+ +E + ++L K +LV
Sbjct: 472 IGVVSQEPVLFS-TTIAENI-CYGR-GNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGE 528
Query: 1122 --QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179
LSGG K+++++A A V + ++LDE T+ +D + + + K + GRT ++
Sbjct: 529 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 588
Query: 1180 HHM 1182
H +
Sbjct: 589 HRL 591
Score = 72.8 bits (177), Expect = 4e-12
Identities = 54/224 (24%), Positives = 111/224 (49%), Gaps = 20/224 (8%)
Query: 1008 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATI-YGHDI-------RTE 1059
L LSL + + Q ++ +G +G GK+T + +L + P +G+ + +G + +
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLN 1111
Query: 1060 MDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEI-----RREMDKMIEDL--E 1112
+ +R LG+ Q +LFD ++ E++ + + ++Q+EI + IE L +
Sbjct: 1112 VQWLRAQLGIVSQEPILFD-CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHK 1170
Query: 1113 LSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPG 1172
+ LSGG K+++++A A + + ++LDE T+ +D + + + + + K + G
Sbjct: 1171 YETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREG 1230
Query: 1173 RTILLSTHHMDEADLLGDRIAIISHGKLKCCGSP---LFLKGTY 1213
RT ++ H + D I + +G++K G+ L KG Y
Sbjct: 1231 RTCIVIAHRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQKGIY 1273
Score = 57.8 bits (138), Expect = 1e-07
Identities = 58/217 (26%), Positives = 99/217 (45%), Gaps = 22/217 (10%)
Query: 2074 LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVN-------GHSVLKELLQ- 2125
L L V+ G+ L+G +G GK++ ++L G FV+ G K +Q
Sbjct: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQW 1114
Query: 2126 VQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWA--------LEKLELT 2177
++ LG Q LFD + E++ R +S + K A L T
Sbjct: 1115 LRAQLGIVSQEPILFD-CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYET 1173
Query: 2178 KYADKPAGTY-SGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTG 2236
+ DK GT SGG K++++ A ALI P + LDE T+ +D ++ + + LD + G
Sbjct: 1174 RVGDK--GTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQE-ALDKAREG 1230
Query: 2237 RSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHL 2273
R+ ++ +H + + + + NGR++ G+ Q L
Sbjct: 1231 RTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1266
Score = 48.1 bits (113), Expect = 1e-04
Identities = 51/227 (22%), Positives = 105/227 (46%), Gaps = 14/227 (6%)
Query: 2028 VEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLL 2087
++++ + S +R + D+ ++ ++ Y SR +IL L L V+ G+ L+
Sbjct: 371 IDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILK--GLNLKVQSGQTVALV 428
Query: 2088 GVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLK-ELLQVQQSLGYCPQCDALFDELTAR 2146
G +G GK++T +++ G ++G + + +++ +G Q LF T
Sbjct: 429 GSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFST-TIA 487
Query: 2147 EHLQLYTRLRGISWKDEARVVKWALEKLELTKYADK-------PAGTYSGGNKRKLSTAI 2199
E++ Y R ++ + + VK A + K K SGG K++++ A
Sbjct: 488 ENI-CYGR-GNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIAR 545
Query: 2200 ALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSM 2246
AL+ P + LDE T+ +D ++ + LD + GR+ ++ +H +
Sbjct: 546 ALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRL 591
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,410,367
Number of Sequences: 37866
Number of extensions: 4671308
Number of successful extensions: 23057
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 101
Number of HSP's that attempted gapping in prelim test: 21748
Number of HSP's gapped (non-prelim): 1007
length of query: 2436
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2317
effective length of database: 13,741,464
effective search space: 31838972088
effective search space used: 31838972088
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.