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Search of human proteins with 4507687
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507687 transient receptor potential cation channel,
subfamily C, member 3 isoform b [Homo sapiens]
(848 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194733735 transient receptor potential cation channel, subfam... 1684 0.0
gi|4507687 transient receptor potential cation channel, subfamil... 1684 0.0
gi|9966865 transient receptor potential cation channel, subfamil... 1363 0.0
gi|5730102 transient receptor potential cation channel, subfamil... 1251 0.0
gi|6912736 transient receptor potential cation channel, subfamil... 548 e-156
gi|209863026 transient receptor potential cation channel, subfam... 536 e-152
gi|209863024 transient receptor potential cation channel, subfam... 536 e-152
gi|7706747 transient receptor potential cation channel, subfamil... 536 e-152
gi|209863030 transient receptor potential cation channel, subfam... 519 e-147
gi|209863028 transient receptor potential cation channel, subfam... 442 e-124
gi|4507685 transient receptor potential cation channel, subfamil... 428 e-120
gi|169216484 PREDICTED: similar to transient receptor potential ... 383 e-106
gi|209863032 transient receptor potential cation channel, subfam... 327 2e-89
gi|239754785 PREDICTED: similar to transient receptor potential ... 223 6e-58
gi|239749299 PREDICTED: similar to transient receptor potential ... 223 6e-58
gi|239743393 PREDICTED: hypothetical protein XP_002342847, parti... 223 6e-58
gi|239509090 PREDICTED: similar to transient receptor potential ... 223 6e-58
gi|4507689 transient receptor potential cation channel, subfamil... 88 4e-17
gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens] 68 4e-11
gi|109689695 transient receptor potential cation channel, subfam... 67 5e-11
gi|94538366 transient receptor potential cation channel, subfami... 63 1e-09
gi|148612863 transient receptor potential cation channel, subfam... 60 9e-09
gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens] 59 2e-08
gi|4505835 polycystin 2 [Homo sapiens] 57 7e-08
gi|154091312 transient receptor potential cation channel, subfam... 57 9e-08
gi|154091308 transient receptor potential cation channel, subfam... 57 9e-08
gi|154091310 transient receptor potential cation channel, subfam... 57 9e-08
gi|154091320 transient receptor potential cation channel, subfam... 57 9e-08
gi|154091318 transient receptor potential cation channel, subfam... 57 9e-08
gi|154091316 transient receptor potential cation channel, subfam... 57 9e-08
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 1684 bits (4360), Expect = 0.0
Identities = 848/848 (100%), Positives = 848/848 (100%)
Query: 1 MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLE 60
MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLE
Sbjct: 74 MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLE 133
Query: 61 ESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEA 120
ESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEA
Sbjct: 134 ESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEA 193
Query: 121 ILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLL 180
ILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLL
Sbjct: 194 ILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLL 253
Query: 181 MKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALE 240
MKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALE
Sbjct: 254 MKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALE 313
Query: 241 LSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVH 300
LSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVH
Sbjct: 314 LSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVH 373
Query: 301 RHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGL 360
RHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGL
Sbjct: 374 RHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGL 433
Query: 361 PFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT 420
PFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT
Sbjct: 434 PFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT 493
Query: 421 DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIF 480
DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIF
Sbjct: 494 DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIF 553
Query: 481 IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG 540
IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG
Sbjct: 554 IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG 613
Query: 541 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYS 600
LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYS
Sbjct: 614 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYS 673
Query: 601 YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVV 660
YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVV
Sbjct: 674 YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVV 733
Query: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI 720
VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI
Sbjct: 734 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI 793
Query: 721 MRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMK 780
MRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMK
Sbjct: 794 MRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMK 853
Query: 781 RLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKL 840
RLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKL
Sbjct: 854 RLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKL 913
Query: 841 NPSMLRCE 848
NPSMLRCE
Sbjct: 914 NPSMLRCE 921
>gi|4507687 transient receptor potential cation channel, subfamily
C, member 3 isoform b [Homo sapiens]
Length = 848
Score = 1684 bits (4360), Expect = 0.0
Identities = 848/848 (100%), Positives = 848/848 (100%)
Query: 1 MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLE 60
MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLE
Sbjct: 1 MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLE 60
Query: 61 ESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEA 120
ESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEA
Sbjct: 61 ESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEA 120
Query: 121 ILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLL 180
ILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLL
Sbjct: 121 ILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLL 180
Query: 181 MKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALE 240
MKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALE
Sbjct: 181 MKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALE 240
Query: 241 LSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVH 300
LSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVH
Sbjct: 241 LSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVH 300
Query: 301 RHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGL 360
RHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGL
Sbjct: 301 RHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGL 360
Query: 361 PFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT 420
PFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT
Sbjct: 361 PFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT 420
Query: 421 DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIF 480
DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIF
Sbjct: 421 DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIF 480
Query: 481 IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG 540
IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG
Sbjct: 481 IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG 540
Query: 541 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYS 600
LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYS
Sbjct: 541 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYS 600
Query: 601 YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVV 660
YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVV
Sbjct: 601 YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVV 660
Query: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI 720
VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI
Sbjct: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI 720
Query: 721 MRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMK 780
MRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMK
Sbjct: 721 MRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMK 780
Query: 781 RLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKL 840
RLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKL
Sbjct: 781 RLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKL 840
Query: 841 NPSMLRCE 848
NPSMLRCE
Sbjct: 841 NPSMLRCE 848
>gi|9966865 transient receptor potential cation channel, subfamily
C, member 7 [Homo sapiens]
Length = 862
Score = 1363 bits (3529), Expect = 0.0
Identities = 682/841 (81%), Positives = 754/841 (89%), Gaps = 7/841 (0%)
Query: 8 RRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNV 67
RR T +REKGRRQA+RGPA+MFN++GTSLT EEERFLD+AEYGNIPVVRKMLEESKTLN
Sbjct: 12 RRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNF 71
Query: 68 NCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGF 127
NCVDYMGQNALQLAVGNEHLEVTELLLKKENLAR+GDALLLAISKGYVRIVEAILNHP F
Sbjct: 72 NCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAF 131
Query: 128 AASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIE 187
A +RLTLSP EQEL+DDDFYAYDEDGTRFS DITPIILAAHCQ+YE+VH+LL+KGARIE
Sbjct: 132 AQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIE 191
Query: 188 RPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAK 247
RPHDYFCKC +C EKQR DSFSHSRSR+NAYKGLAS AYLSLSSEDPVLTALELSNELA+
Sbjct: 192 RPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELAR 251
Query: 248 LANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLS 307
LANIE EFKNDYRKLSMQCKDFVVGVLDLCRD+EEVEAILNGD+ + H+ SLS
Sbjct: 252 LANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQ--VWSDHHRPSLS 309
Query: 308 RVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGY 367
R+KLAIKYEVKKFVAHPNCQQQLLT+WYENLSGLR+Q+IA+K L V V++GLPFLAI Y
Sbjct: 310 RIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAY 369
Query: 368 WIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIF 427
WIAPCS+LG+ LRSPFMKFVAHA SF IFLGLLV NASDRFEG+ TLPN T TDYPKQIF
Sbjct: 370 WIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIF 429
Query: 428 RVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTAR 487
RVKTTQF+WTEMLIM WVLGM+WSECKE+W EGPREY+L LWN+LDFGMLSIF+A+FTAR
Sbjct: 430 RVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTAR 489
Query: 488 FLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVV 547
F+AFL+AT+AQ YVD +VQ+ L V+LPPE+ YFTYARDKW PSDPQIISEGLYAIAVV
Sbjct: 490 FMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVV 549
Query: 548 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKV 607
LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMV+FIMVF AFMIGMF LYSYY GAK
Sbjct: 550 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKY 609
Query: 608 NAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLI 667
N AFTTVEESFKTLFWSIFGLSEV SVVLKYDHKFIENIGYVLYG+YNVTMVVVLLNMLI
Sbjct: 610 NPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLI 669
Query: 668 AMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRI---- 723
AMIN+SYQEIE+D+DVEWKFAR+KLWLSYFD+G+TLP PF+LVPSPKSF Y IMRI
Sbjct: 670 AMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCL 729
Query: 724 VNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLI 783
+ K + + + D+EMGM NSK + + Q+ R E+ + N+ L++PTRYQ+IMKRLI
Sbjct: 730 IKLCKSKAKSCENDLEMGMLNSKFKKTRY-QAGMRNSENLTANNTLSKPTRYQKIMKRLI 788
Query: 784 KRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPS 843
KRYVLKAQVD+ENDEVNEGELKEIKQDISSLRYELLE+KSQAT ELA LI +LSEK +
Sbjct: 789 KRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKN 848
Query: 844 M 844
+
Sbjct: 849 L 849
>gi|5730102 transient receptor potential cation channel, subfamily
C, member 6 [Homo sapiens]
Length = 931
Score = 1251 bits (3238), Expect = 0.0
Identities = 628/857 (73%), Positives = 723/857 (84%), Gaps = 25/857 (2%)
Query: 8 RRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNV 67
RR TV+REKGRR A RGPA+MF+DR TSL+ EEERFLDAAEYGNIPVVRKMLEE +LNV
Sbjct: 67 RRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNV 126
Query: 68 NCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGF 127
NCVDYMGQNALQLAV NEHLE+TELLLKKENL+R+GDALLLAISKGYVRIVEAIL+HP F
Sbjct: 127 NCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAF 186
Query: 128 AASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIE 187
A KRL SP + ELQ DDFYAYDEDGTRFS D+TPIILAAHCQ+YE+VH LL KGARIE
Sbjct: 187 AEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIE 246
Query: 188 RPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAK 247
RPHDYFCKC DC +KQ+HDSFSHSRSRINAYKGLASPAYLSLSSEDPV+TALELSNELA
Sbjct: 247 RPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAV 306
Query: 248 LANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLS 307
LANIEKEFKNDY+KLSMQCKDFVVG+LDLCR++EEVEAILNGD+E+ + + R +LS
Sbjct: 307 LANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR--PNLS 364
Query: 308 RVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGY 367
R+KLAIKYEVKKFVAHPNCQQQLL+IWYENLSGLR+QT+A+K LVVL VA+GLPFLA+ Y
Sbjct: 365 RLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIY 424
Query: 368 WIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIF 427
W APCS++GKI+R PFMKFVAHAASF IFLGLLV NA+DRFEG LPN T TD KQ+F
Sbjct: 425 WFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLF 484
Query: 428 RVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTAR 487
R+KT+ F+W EMLI+ WV+GM+W+ECKE+W +GP+EY+ +LWN+LDFGML+IF A+F AR
Sbjct: 485 RMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIAR 544
Query: 488 FLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVV 547
F+AF A+KAQ +D+ DL++VTL ++Y+ AR KW PSDPQIISEGLYAIAVV
Sbjct: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVV 604
Query: 548 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKV 607
LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMV+FIMVF AFMIGMF LYSYY+GAK
Sbjct: 605 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQ 664
Query: 608 NAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLI 667
N AFTTVEESFKTLFW+IFGLSEV SVV+ Y+HKFIENIGYVLYG+YNVTMV+VLLNMLI
Sbjct: 665 NEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLI 724
Query: 668 AMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMR----I 723
AMINSS+QEIEDD+DVEWKFAR+KLW SYF++G+TLP PF+LVPSPKS Y +++ I
Sbjct: 725 AMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWI 784
Query: 724 VNFPKCRRRRLQKDIEMGMGNSKSRLNLF-------------------TQSNSRVFESHS 764
+ ++ Q+D EM N + +L + Q + R E
Sbjct: 785 SELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFH 844
Query: 765 FNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQ 824
NS N P +YQ+IMKRLIKRYVL+AQ+DKE+DEVNEGELKEIKQDISSLRYELLE+KSQ
Sbjct: 845 LNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQ 904
Query: 825 ATEELAILIHKLSEKLN 841
TE+LA LI +L EKL+
Sbjct: 905 NTEDLAELIRELGEKLS 921
>gi|6912736 transient receptor potential cation channel, subfamily
C, member 5 [Homo sapiens]
Length = 973
Score = 548 bits (1412), Expect = e-156
Identities = 316/805 (39%), Positives = 468/805 (58%), Gaps = 90/805 (11%)
Query: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESK---TLNVNCVDYMGQNALQLAVGNEHLEVT 90
T L+AEE+ FL+A E G+ V++ L+E++ +N+NC+D +G++AL +A+ NE+LE+
Sbjct: 27 TELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIM 86
Query: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150
ELLL +GDALL AI K V VE +L++ + K++ + D F
Sbjct: 87 ELLLNHS--VYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTL-----MMDTQF--- 136
Query: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210
+ F+PDITPI+LAAH YE++ +L+ K I RPH C C +C+ DS H
Sbjct: 137 ----SEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRH 192
Query: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270
SRSR+N YK LASP+ ++LSSEDP+LTA L EL +L+ +E EFK +Y +LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFA 252
Query: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330
+LD R S E+E ILN + +E L+ ++ L+++K+AIKY K+FVA PNCQQ L
Sbjct: 253 KDLLDQARSSRELEIILNHRDDHSEELDPQKYH-DLAKLKVAIKYHQKEFVAQPNCQQLL 311
Query: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390
T+WY+ G R + +K L + + P L+I Y I+P S LG ++ PF+KF+ H
Sbjct: 312 ATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHT 371
Query: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450
AS++ FL +L+ + +I TD V+ T E +I+ WVLG +W
Sbjct: 372 ASYLTFLFMLLLASQ----------HIVRTD-----LHVQGPPPTVVEWMILPWVLGFIW 416
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
E KE+W G EYI WN++DF M S+++A + + +A+++ ++
Sbjct: 417 GEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSR------------ 464
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
R++W P +I+E L+AI+ +LS R+ + AN GPLQISL
Sbjct: 465 --------------PREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYY--------------LGAKVNAAFTTVEE 616
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E
Sbjct: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
Query: 617 SFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQE 676
+ ++LFWS+FGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ
Sbjct: 571 TLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQL 630
Query: 677 IEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQK 736
I D +D+EWKFAR+KLW+SYFD+G TLPPPF+++PSPKSF+Y + N C +R
Sbjct: 631 IADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLY-LGNWFNNTFCPKRDPD- 688
Query: 737 DIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYV-LKAQVDKE 795
G + R N R F + +S++ Q YQ++++ L+KRYV + K
Sbjct: 689 ------GRRRRR-------NLRSFTERNADSLI-QNQHYQEVIRNLVKRYVAAMIRNSKT 734
Query: 796 NDEVNEGELKEIKQDISSLRYELLE 820
++ + E KE+KQDISS RYE+L+
Sbjct: 735 HEGLTEENFKELKQDISSFRYEVLD 759
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 536 bits (1382), Expect = e-152
Identities = 314/801 (39%), Positives = 457/801 (57%), Gaps = 91/801 (11%)
Query: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 90
+ L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150
ELLL +GDALL AI K V VE +LNH + K++
Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210
D+ + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270
SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330
+LD R S E+E ILN L + L+R+KLAIKY K+FVA PNCQQ L
Sbjct: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
Query: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390
+ WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H
Sbjct: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
Query: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450
AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W
Sbjct: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
E K++W G ++YI WN++DF M S+++A + + +AF++ +
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
L P R+ W P +++E L+AIA + S R+ + AN GPLQISL
Sbjct: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 619
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ +
Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
Query: 620 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 679
+LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I D
Sbjct: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629
Query: 680 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIE 739
+D+EWKFAR+KLW+SYF++G TLP PF+++PSPKS Y I I C+++ +K
Sbjct: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTH-LCKKKMRRKPES 688
Query: 740 MGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE- 798
G ++ N L + +YQ++M+ L+KRYV D + +E
Sbjct: 689 FGTIGRRAADN------------------LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEG 730
Query: 799 VNEGELKEIKQDISSLRYELL 819
+ E KE+KQDISS R+E+L
Sbjct: 731 LTEENFKELKQDISSFRFEVL 751
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 536 bits (1382), Expect = e-152
Identities = 316/801 (39%), Positives = 462/801 (57%), Gaps = 86/801 (10%)
Query: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 90
+ L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150
ELLL +GDALL AI K V VE +LNH + K++
Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210
D+ + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270
SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330
+LD R S E+E ILN L + L+R+KLAIKY K+FVA PNCQQ L
Sbjct: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
Query: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390
+ WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H
Sbjct: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
Query: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450
AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W
Sbjct: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
E K++W G ++YI WN++DF M S+++A + + +AF++ +
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
L P R+ W P +++E L+AIA + S R+ + AN GPLQISL
Sbjct: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 619
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ +
Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
Query: 620 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 679
+LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I D
Sbjct: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629
Query: 680 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIE 739
+D+EWKFAR+KLW+SYF++G TLP PF+++PSPKS Y I I C+++ +K
Sbjct: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTH-LCKKKMRRKPES 688
Query: 740 MGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE- 798
G + + TQ + R ++ L + +YQ++M+ L+KRYV D + +E
Sbjct: 689 FG------TIGVRTQ-HRRAADN------LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEG 735
Query: 799 VNEGELKEIKQDISSLRYELL 819
+ E KE+KQDISS R+E+L
Sbjct: 736 LTEENFKELKQDISSFRFEVL 756
>gi|7706747 transient receptor potential cation channel, subfamily
C, member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 536 bits (1382), Expect = e-152
Identities = 314/801 (39%), Positives = 457/801 (57%), Gaps = 91/801 (11%)
Query: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 90
+ L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150
ELLL +GDALL AI K V VE +LNH + K++
Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210
D+ + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270
SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330
+LD R S E+E ILN L + L+R+KLAIKY K+FVA PNCQQ L
Sbjct: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
Query: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390
+ WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H
Sbjct: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
Query: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450
AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W
Sbjct: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
E K++W G ++YI WN++DF M S+++A + + +AF++ +
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
L P R+ W P +++E L+AIA + S R+ + AN GPLQISL
Sbjct: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 619
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ +
Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
Query: 620 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 679
+LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I D
Sbjct: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629
Query: 680 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIE 739
+D+EWKFAR+KLW+SYF++G TLP PF+++PSPKS Y I I C+++ +K
Sbjct: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTH-LCKKKMRRKPES 688
Query: 740 MGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE- 798
G ++ N L + +YQ++M+ L+KRYV D + +E
Sbjct: 689 FGTIGRRAADN------------------LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEG 730
Query: 799 VNEGELKEIKQDISSLRYELL 819
+ E KE+KQDISS R+E+L
Sbjct: 731 LTEENFKELKQDISSFRFEVL 751
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 519 bits (1336), Expect = e-147
Identities = 303/780 (38%), Positives = 442/780 (56%), Gaps = 90/780 (11%)
Query: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 90
+ L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150
ELLL +GDALL AI K V VE +LNH + K++
Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210
D+ + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270
SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330
+LD R S E+E ILN L + L+R+KLAIKY K+FVA PNCQQ L
Sbjct: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
Query: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390
+ WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H
Sbjct: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
Query: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450
AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W
Sbjct: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
E K++W G ++YI WN++DF M S+++A + + +AF++ +
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
L P R+ W P +++E L+AIA + S R+ + AN GPLQISL
Sbjct: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 619
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ +
Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
Query: 620 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 679
+LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I D
Sbjct: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629
Query: 680 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIE 739
+D+EWKFAR+KLW+SYF++G TLP PF+++PSPKS Y I I C+++ +K
Sbjct: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTH-LCKKKMRRKPES 688
Query: 740 MGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEV 799
G ++ N L + +YQ++M+ L+KRYV D + +EV
Sbjct: 689 FGTIGRRAADN------------------LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEV 730
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 442 bits (1137), Expect = e-124
Identities = 259/658 (39%), Positives = 375/658 (56%), Gaps = 71/658 (10%)
Query: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 90
+ L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150
ELLL +GDALL AI K V VE +LNH + K++
Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210
D+ + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270
SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330
+LD R S E+E ILN L + L+R+KLAIKY K+FVA PNCQQ L
Sbjct: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
Query: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390
+ WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H
Sbjct: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
Query: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450
AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W
Sbjct: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
E K++W G ++YI WN++DF M S+++A + + +AF++ +
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
L P R+ W P +++E L+AIA + S R+ + AN GPLQISL
Sbjct: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 619
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ +
Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
Query: 620 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEI 677
+LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I
Sbjct: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLI 627
Score = 46.2 bits (108), Expect = 1e-04
Identities = 23/52 (44%), Positives = 35/52 (67%), Gaps = 1/52 (1%)
Query: 769 LNQPTRYQQIMKRLIKRYVLKAQVDKENDE-VNEGELKEIKQDISSLRYELL 819
L + +YQ++M+ L+KRYV D + +E + E KE+KQDISS R+E+L
Sbjct: 635 LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 686
>gi|4507685 transient receptor potential cation channel, subfamily
C, member 1 [Homo sapiens]
Length = 759
Score = 428 bits (1101), Expect = e-120
Identities = 274/812 (33%), Positives = 420/812 (51%), Gaps = 145/812 (17%)
Query: 37 TAEEERFLDAAEYGNIPVVRKMLEESKT--LNVNCVDYMGQNALQLAVGNEHLEVTELLL 94
T E+ FL A + G+ +V+K+LEE+ + LN+NCVD +G+NA+ + + NE+L++ +LLL
Sbjct: 45 TLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLL 104
Query: 95 KKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDG 154
G +++E I N P ++ +
Sbjct: 105 ----------------DYGCQKLMERIQN-PEYSTTM----------------------- 124
Query: 155 TRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSR 214
D+ P+ILAAH YE++ MLL + + +PH C+C C K + DS HSR R
Sbjct: 125 -----DVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFR 179
Query: 215 INAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVL 274
++ Y+ LASPA + L+ EDP+L A ELS +L +L+ +E EF+NDY +L+ QCK F +L
Sbjct: 180 LDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLL 239
Query: 275 DLCRDSEEVEAILNGDLESAEPLE---VHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLL 331
R+S E+E ILN S EPL+ + + +LSR+KLAIKY K+FV+ NCQQ L
Sbjct: 240 AQARNSRELEVILN-HTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLN 298
Query: 332 TIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAA 391
T+W+ +SG R + K + VL V + P L++ Y IAP S+ G+I+ +PFMKF+ H A
Sbjct: 299 TVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGA 358
Query: 392 SFIIFLGL-----LVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVL 446
S+ FL L LV+N + T P + DY L+++W++
Sbjct: 359 SYFTFLLLLNLYSLVYNEDKK---NTMGPALERIDY-----------------LLILWII 398
Query: 447 GMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQ 506
GM+WS+ K LW EG +++ + N L F M S+++A F + +A K + D
Sbjct: 399 GMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAH---NKFHDFAD---- 451
Query: 507 ESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPL 566
R W P +++EGL+A A VLS+ R+ ++ + GPL
Sbjct: 452 -------------------RKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPL 492
Query: 567 QISLGRTVKDIFKFMVLFIMVFFAFMIGMFILY-------------SYYLGAKVNAAFTT 613
QIS+G+ ++D KF+ +F++V F+F IG+ LY + + N F +
Sbjct: 493 QISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHS 552
Query: 614 VEESFKTLFWSIFGLSEVTSVVLK--YDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMIN 671
+ LFW IF L+ V V + Y + +G V+ G YNV +V+VL +L+AM++
Sbjct: 553 FIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLH 612
Query: 672 SSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRR 731
S+Q I + D EWKFAR+KLWLSYFDD TLPPPF+++PSPK+ Y I
Sbjct: 613 KSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMI----------- 661
Query: 732 RRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILN----QPTRYQQIMKRLIKRYV 787
+S S+ S +V +S N + YQ++M L+ RY+
Sbjct: 662 ------------SSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYL 709
Query: 788 LK-AQVDKENDEVNEGELKEIKQDISSLRYEL 818
Q + D+ L E++QD+S R E+
Sbjct: 710 TSMRQKMQSTDQATVENLNELRQDLSKFRNEI 741
>gi|169216484 PREDICTED: similar to transient receptor potential
channel subfamily C member 6 [Homo sapiens]
Length = 304
Score = 383 bits (983), Expect = e-106
Identities = 184/277 (66%), Positives = 226/277 (81%)
Query: 447 GMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQ 506
GM+W+ECKE+W +GP+EY+ +LWN+LDFGML+I A+F ARF AF A+KAQ D+
Sbjct: 17 GMIWAECKEIWTQGPKEYLFELWNMLDFGMLAILSASFIARFRAFWHASKAQSITDASDT 76
Query: 507 ESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPL 566
DL++VTL ++Y++ AR +W PSDP+++SEGL A+AVVLSFS IA ILPANESFGPL
Sbjct: 77 LKDLTKVTLGDNVKYYSLARREWDPSDPRMVSEGLCAVAVVLSFSGIACILPANESFGPL 136
Query: 567 QISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIF 626
Q+SLG VKDIF+FM++FIMVF AFMIGMF LYSYY+ K N AFTTVEESFKTLFW+ F
Sbjct: 137 QMSLGGAVKDIFRFMLIFIMVFVAFMIGMFNLYSYYIDVKQNEAFTTVEESFKTLFWATF 196
Query: 627 GLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWK 686
LS V SVV+ Y HKFIENIGYVLYG+Y+VTMV+VLLNMLIAMINSS QEIEDD+DVEWK
Sbjct: 197 VLSAVKSVVINYSHKFIENIGYVLYGVYDVTMVIVLLNMLIAMINSSLQEIEDDADVEWK 256
Query: 687 FARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRI 723
FAR+KLW S F +G+ LP PF+LVP P S ++++
Sbjct: 257 FARAKLWFSCFGEGRALPVPFNLVPGPGSLFCLLLKL 293
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 327 bits (839), Expect = 2e-89
Identities = 209/609 (34%), Positives = 323/609 (53%), Gaps = 82/609 (13%)
Query: 231 SEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEE----VEAI 286
SE L A+E + + ++E+ Y K+++ C D + L E +E +
Sbjct: 32 SEKAYLNAVEKGDYASVKKSLEEA--EIYFKININCIDPLGRTALLIAIENENLELIELL 89
Query: 287 LNGDLESAEPLEVHRHKASLSRVKLAIKYEV----KKFVAHPNCQQQLLTIWYENLSGLR 342
L+ ++ + L K + V+L + ++ K+FVA PNCQQ L + WY+ G R
Sbjct: 90 LSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQFVAQPNCQQLLASRWYDEFPGWR 149
Query: 343 EQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVF 402
+ A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H AS++ FL LL+
Sbjct: 150 RRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLL 209
Query: 403 NASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPR 462
+ +I +D +Q T E +I+ WVLG +W E K++W G +
Sbjct: 210 ASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQ 254
Query: 463 EYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYF 522
+YI WN++DF M S+++A + + +AF++ + L P
Sbjct: 255 DYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS------------------ALNP----- 291
Query: 523 TYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMV 582
R+ W P +++E L+AIA + S R+ + AN GPLQISLGR + DI KF+
Sbjct: 292 ---RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLF 348
Query: 583 LFIMVFFAFMIGMFILYSYYLGAK-----------VNAAFTTVEESFKTLFWSIFGLSEV 631
++ +V AF G+ LY YY K N AF+T+ E+ ++LFWSIFGL +
Sbjct: 349 IYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL 408
Query: 632 TSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSK 691
+K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I D +D+EWKFAR+K
Sbjct: 409 YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTK 468
Query: 692 LWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNL 751
LW+SYF++G TLP PF+++PSPKS Y I I C+++ +K G ++ N
Sbjct: 469 LWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTH-LCKKKMRRKPESFGTIGRRAADN- 526
Query: 752 FTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE-VNEGELKEIKQD 810
L + +YQ++M+ L+KRYV D + +E + E KE+KQD
Sbjct: 527 -----------------LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQD 569
Query: 811 ISSLRYELL 819
ISS R+E+L
Sbjct: 570 ISSFRFEVL 578
Score = 76.6 bits (187), Expect = 9e-14
Identities = 46/118 (38%), Positives = 70/118 (59%), Gaps = 5/118 (4%)
Query: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 90
+ L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFY 148
ELLL +GDALL AI K V VE +LNH + K+ P Q+L +Y
Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQFVAQPNCQQLLASRWY 142
>gi|239754785 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 223 bits (568), Expect = 6e-58
Identities = 108/165 (65%), Positives = 132/165 (80%)
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
+ECKE+W +GP+EY+ +LWN+LDFGML IF A F ARF AF A+KAQ +D+ DL
Sbjct: 3 TECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDL 62
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
+EVTL ++Y+ AR +W+PSDP ++SEGL A+AVVLSFS IA ILPANESFGPLQ SL
Sbjct: 63 TEVTLGDNVKYYNLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
G VKDIF+FMV+FIMVF AFMIGMF LYSYY+GAK N AFTT++
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTLK 167
>gi|239749299 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 223 bits (568), Expect = 6e-58
Identities = 108/165 (65%), Positives = 132/165 (80%)
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
+ECKE+W +GP+EY+ +LWN+LDFGML IF A F ARF AF A+KAQ +D+ DL
Sbjct: 3 TECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDL 62
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
+EVTL ++Y+ AR +W+PSDP ++SEGL A+AVVLSFS IA ILPANESFGPLQ SL
Sbjct: 63 TEVTLGDNVKYYNLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
G VKDIF+FMV+FIMVF AFMIGMF LYSYY+GAK N AFTT++
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTLK 167
>gi|239743393 PREDICTED: hypothetical protein XP_002342847, partial
[Homo sapiens]
Length = 182
Score = 223 bits (568), Expect = 6e-58
Identities = 108/165 (65%), Positives = 132/165 (80%)
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
+ECKE+W +GP+EY+ +LWN+LDFGML IF A F ARF AF A+KAQ +D+ DL
Sbjct: 3 TECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDL 62
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
+EVTL ++Y+ AR +W+PSDP ++SEGL A+AVVLSFS IA ILPANESFGPLQ SL
Sbjct: 63 TEVTLGDNVKYYNLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
G VKDIF+FMV+FIMVF AFMIGMF LYSYY+GAK N AFTT++
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTLK 167
>gi|239509090 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 223 bits (568), Expect = 6e-58
Identities = 108/165 (65%), Positives = 132/165 (80%)
Query: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
+ECKE+W +GP+EY+ +LWN+LDFGML IF A F ARF AF A+KAQ +D+ DL
Sbjct: 3 TECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDL 62
Query: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
+EVTL ++Y+ AR +W+PSDP ++SEGL A+AVVLSFS IA ILPANESFGPLQ SL
Sbjct: 63 TEVTLGDNVKYYNLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
G VKDIF+FMV+FIMVF AFMIGMF LYSYY+GAK N AFTT++
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTLK 167
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 87.8 bits (216), Expect = 4e-17
Identities = 117/554 (21%), Positives = 217/554 (39%), Gaps = 129/554 (23%)
Query: 231 SEDPVLTALELSNELAKLANIEKEFKNDYRKLSM--QCKDFVVGVLDLC--RDSEEVEAI 286
S+D + AL S L +L+ E++ + L++ + + +GV C +D E + +
Sbjct: 645 SQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKL 704
Query: 287 LNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLS---GLRE 343
L V + ++LA++ + KFV+H Q L +W+ LS GL
Sbjct: 705 LT---------RVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWR 755
Query: 344 QTIAIKCLVVLVVALGLPFLA-----IGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLG 398
T+ + +L+ L + F +G P +R +P + F + S+ FL
Sbjct: 756 VTLCMLAFPLLLTGL-ISFREKRLQDVG---TPAARARAFFTAPVVVFHLNILSYFAFLC 811
Query: 399 LLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWL 458
L + F+ + + W E I +W+ ++ E ++L+
Sbjct: 812 LFAYVLMVDFQPVPS----------------------WCECAIYLWLFSLVCEEMRQLFY 849
Query: 459 EGPRE---------YILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESD 509
+ P E Y WN LD G + +F+A T R
Sbjct: 850 D-PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCR---------------------- 886
Query: 510 LSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 569
L TL P + ++ +L R+ +I +++ GP I
Sbjct: 887 LIPATLYP--------------------GRVILSLDFILFCLRLMHIFTISKTLGPKIII 926
Query: 570 LGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT-TVEESFKTLFWSIFGL 628
+ R +KD+F F+ L + +F + + + +V+ F V S+ T+F I G
Sbjct: 927 VKRMMKDVFFFLFLLAVWVVSFGVAKQAIL-IHNERRVDWLFRGAVYHSYLTIFGQIPGY 985
Query: 629 SEVTSVVLKYDH-----------------------KFIENIGYVLYGIYNVTMVVVLLNM 665
+ V +H F E + +L +Y + ++LLN+
Sbjct: 986 --IDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNL 1043
Query: 666 LIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVN 725
LIAM N ++Q++++ +D WKF R L + + PPPF L+ + F+ + ++
Sbjct: 1044 LIAMFNYTFQQVQEHTDQIWKFQRHDL-IEEYHGRPAAPPPFILLSHLQLFIKRV--VLK 1100
Query: 726 FPKCRRRRLQKDIE 739
P R ++L+ +E
Sbjct: 1101 TPAKRHKQLKNKLE 1114
>gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens]
Length = 805
Score = 67.8 bits (164), Expect = 4e-11
Identities = 69/307 (22%), Positives = 133/307 (43%), Gaps = 56/307 (18%)
Query: 394 IIFLGLLVFNASDRFEGITTLPNITVTDYPK--------QIFRVKTTQFT--WT------ 437
++F+ V+NA+ + L V ++P QI VK ++ W
Sbjct: 300 VVFIDFSVYNANINLFCVLRL----VVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGC 355
Query: 438 EMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKA 497
E++ V++ + E EL + R Y+ +WN+LD ++ + I A L+ +
Sbjct: 356 EVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
Query: 498 QQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYIL 557
+ L + + ++ + + ++ + A+ + ++ +I +
Sbjct: 415 MGKL--------LQQPNTYADFEFLAFWQTQY---------NNMNAVNLFFAWIKIFKYI 457
Query: 558 PANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEES 617
N++ L +L R KDI F V+F +VFFA+ ++L F T E+
Sbjct: 458 SFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLL------------FGTQVEN 505
Query: 618 FKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMV----VVLLNMLIAMINSS 673
F T IF ++ ++ +D+ I+N +L Y VT V VLLNM +A+IN +
Sbjct: 506 FSTFIKCIF--TQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDT 563
Query: 674 YQEIEDD 680
Y E++++
Sbjct: 564 YSEVKEE 570
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 67.4 bits (163), Expect = 5e-11
Identities = 111/525 (21%), Positives = 198/525 (37%), Gaps = 113/525 (21%)
Query: 236 LTALELSNELAKLANIEKEFK--NDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLES 293
L AL S L LA ++ + + +L+ + + V + C S+E +
Sbjct: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDE---------DL 639
Query: 294 AEPLEVHRHKA--SLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCL 351
AE L V+ +A + ++LA++ + F+A P Q L WY +S + I CL
Sbjct: 640 AEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCL 699
Query: 352 VVLVVALGLPFLAIGYWIAPCSRLGKIL-------RSPFMKFVAHAASFIIFLGLLVFNA 404
++ + +G F + + P + K+L SPF+ F + +I FL L +
Sbjct: 700 FIIPL-VGCGF--VSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVL 756
Query: 405 SDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREY 464
F + P E+++ V + E ++ ++ G Y
Sbjct: 757 LMDFHSVPHPP----------------------ELVLYSLVFVLFCDEVRQWYVNGVN-Y 793
Query: 465 ILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTY 524
LWNV+D L FIA R + + K+ Y +
Sbjct: 794 FTDLWNVMDTLGLFYFIAGIVFRLHS---SNKSSLYSGRVI------------------- 831
Query: 525 ARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLF 584
+ + ++ R+ +I + + GP I L R + D+F F+ LF
Sbjct: 832 -----------------FCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLF 874
Query: 585 IMVFFAFMIGM----------------FILYSYYLGAKVNAAFTTVEESFKTLFWSIFGL 628
+ AF + ++Y YL A + V+ + F
Sbjct: 875 AVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYL-AMFGQVPSDVDGTTYDFAHCTFTG 933
Query: 629 SEVTSVVLKYDH----KFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVE 684
+E + ++ D +F E I L IY ++ ++L+N+L+AM + +++++D
Sbjct: 934 NESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQV 993
Query: 685 WKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKC 729
WKF R L Y +P PF + F YF M + KC
Sbjct: 994 WKFQRYFLVQEYC-SRLNIPFPFIV------FAYFYMVVKKCFKC 1031
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 62.8 bits (151), Expect = 1e-09
Identities = 61/289 (21%), Positives = 127/289 (43%), Gaps = 36/289 (12%)
Query: 466 LQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYA 525
LQ W V+ + + +A R + + K Q + ++QE +T I F
Sbjct: 859 LQEWIVISY---IVSLALEKIREILMSEPGKLSQKIKVWLQE--YWNITDLVAISTFMIG 913
Query: 526 RDKWLPSDPQI-ISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLF 584
L + P + +Y + ++ + R+ I N+ GP + +G+ + D+ F+V+
Sbjct: 914 AILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIM 973
Query: 585 IMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG---LSEVTSVVLKYDHK 641
++V +F + + L + ++ F +W I+G ++ ++ +
Sbjct: 974 LVVLMSFGVARQAI----LHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPP 1029
Query: 642 FIEN-----------------IGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVE 684
EN + L Y + ++L+N+LIA+ N+++ E++ S+
Sbjct: 1030 CGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQV 1089
Query: 685 WKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRR 733
WKF R +L ++ F D LPPP ++ S +Y I+ ++ +CR++R
Sbjct: 1090 WKFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLS-GRCRKKR 1132
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 60.1 bits (144), Expect = 9e-09
Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 22/204 (10%)
Query: 541 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGM-FILY 599
+Y + ++ + R+ L N+ GP + +G+ V ++F +V+ +V +F + ILY
Sbjct: 964 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
Query: 600 SYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENI-------GYVLYG 652
+ ++T ++ +W IFG + + + I I L
Sbjct: 1024 PHEA-----PSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQA 1078
Query: 653 IYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPS 712
+Y ++++N+LIA N+ Y +++ S++ WK+ R ++Y + LPPP ++
Sbjct: 1079 VYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK-PVLPPPLIILSH 1137
Query: 713 PKSFVYFIMRIVNFPKCRRRRLQK 736
S I C+RR+ K
Sbjct: 1138 IVSLFCCI--------CKRRKKDK 1153
>gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens]
Length = 613
Score = 58.5 bits (140), Expect = 2e-08
Identities = 41/152 (26%), Positives = 76/152 (50%), Gaps = 18/152 (11%)
Query: 536 IISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGM 595
I + AI + ++ +I + N++ L +L R VKDI F ++F ++FFA+
Sbjct: 366 IYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLG 425
Query: 596 FILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYN 655
F+++ G++V+ F+T + S F + G ++ I+ +L IY
Sbjct: 426 FLVF----GSQVD-DFSTFQNSIFAQFRIVLG---------DFNFAGIQQANPILGPIYF 471
Query: 656 VTMV----VVLLNMLIAMINSSYQEIEDDSDV 683
+T + VLLNM +A+IN +Y E++ D +
Sbjct: 472 ITFIFFVFFVLLNMFLAIINDTYSEVKADYSI 503
>gi|4505835 polycystin 2 [Homo sapiens]
Length = 968
Score = 57.0 bits (136), Expect = 7e-08
Identities = 52/221 (23%), Positives = 90/221 (40%), Gaps = 36/221 (16%)
Query: 464 YILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFT 523
Y WN LD ++ + + A Q+ L + P ++
Sbjct: 502 YFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQF---------LEDQNTFPNFEHLA 552
Query: 524 YARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVL 583
Y W QI + A+ V + ++ + N + L ++ R KD+F F ++
Sbjct: 553 Y----W-----QIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIM 603
Query: 584 FIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFI 643
F ++F A+ ++++ G +V+ F+T +E T F I G + I
Sbjct: 604 FFIIFLAYAQLAYLVF----GTQVD-DFSTFQECIFTQFRIILG---------DINFAEI 649
Query: 644 ENIGYVLYGIYNVT----MVVVLLNMLIAMINSSYQEIEDD 680
E VL IY T M +LLNM +A+IN +Y E++ D
Sbjct: 650 EEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 690
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 56.6 bits (135), Expect = 9e-08
Identities = 48/226 (21%), Positives = 102/226 (45%), Gaps = 25/226 (11%)
Query: 496 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 555
K + ++ Y +DL + L + +D+ SD ++I Y + ++ + R+
Sbjct: 791 KVKVWLQEYWNVTDLIAILLF-SVGMILRLQDQPFRSDGRVI----YCVNIIYWYIRLLD 845
Query: 556 ILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
I N+ GP + +G+ + D+ F+++ ++V +F + + L ++ +
Sbjct: 846 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI----LFPNEEPSWKLAK 901
Query: 616 ESFKTLFWSIFGLSEVTSV-------VLKYDHKFIEN--------IGYVLYGIYNVTMVV 660
F +W I+G + + D K I+ I + Y + +
Sbjct: 902 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANI 961
Query: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPP 706
+L+N+LIA+ N+++ E++ S+ WKF R +L ++ F + LPPP
Sbjct: 962 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVLPPP 1006
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/103 (18%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 568 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG 627
I LGR + + + ++ + IG +L++Y + K+ + + +E + G
Sbjct: 715 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME-RWPSTQEWIVISYIFTLG 773
Query: 628 LSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMI 670
+ ++ +++ K ++ + L +NVT ++ +L + MI
Sbjct: 774 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 816
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 56.6 bits (135), Expect = 9e-08
Identities = 48/226 (21%), Positives = 102/226 (45%), Gaps = 25/226 (11%)
Query: 496 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 555
K + ++ Y +DL + L + +D+ SD ++I Y + ++ + R+
Sbjct: 804 KVKVWLQEYWNVTDLIAILLF-SVGMILRLQDQPFRSDGRVI----YCVNIIYWYIRLLD 858
Query: 556 ILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
I N+ GP + +G+ + D+ F+++ ++V +F + + L ++ +
Sbjct: 859 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI----LFPNEEPSWKLAK 914
Query: 616 ESFKTLFWSIFGLSEVTSV-------VLKYDHKFIEN--------IGYVLYGIYNVTMVV 660
F +W I+G + + D K I+ I + Y + +
Sbjct: 915 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANI 974
Query: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPP 706
+L+N+LIA+ N+++ E++ S+ WKF R +L ++ F + LPPP
Sbjct: 975 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVLPPP 1019
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/103 (18%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 568 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG 627
I LGR + + + ++ + IG +L++Y + K+ + + +E + G
Sbjct: 728 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME-RWPSTQEWIVISYIFTLG 786
Query: 628 LSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMI 670
+ ++ +++ K ++ + L +NVT ++ +L + MI
Sbjct: 787 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 829
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 56.6 bits (135), Expect = 9e-08
Identities = 48/226 (21%), Positives = 102/226 (45%), Gaps = 25/226 (11%)
Query: 496 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 555
K + ++ Y +DL + L + +D+ SD ++I Y + ++ + R+
Sbjct: 794 KVKVWLQEYWNVTDLIAILLF-SVGMILRLQDQPFRSDGRVI----YCVNIIYWYIRLLD 848
Query: 556 ILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
I N+ GP + +G+ + D+ F+++ ++V +F + + L ++ +
Sbjct: 849 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI----LFPNEEPSWKLAK 904
Query: 616 ESFKTLFWSIFGLSEVTSV-------VLKYDHKFIEN--------IGYVLYGIYNVTMVV 660
F +W I+G + + D K I+ I + Y + +
Sbjct: 905 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANI 964
Query: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPP 706
+L+N+LIA+ N+++ E++ S+ WKF R +L ++ F + LPPP
Sbjct: 965 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVLPPP 1009
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/103 (18%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 568 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG 627
I LGR + + + ++ + IG +L++Y + K+ + + +E + G
Sbjct: 718 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME-RWPSTQEWIVISYIFTLG 776
Query: 628 LSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMI 670
+ ++ +++ K ++ + L +NVT ++ +L + MI
Sbjct: 777 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 819
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 56.6 bits (135), Expect = 9e-08
Identities = 48/226 (21%), Positives = 102/226 (45%), Gaps = 25/226 (11%)
Query: 496 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 555
K + ++ Y +DL + L + +D+ SD ++I Y + ++ + R+
Sbjct: 779 KVKVWLQEYWNVTDLIAILLF-SVGMILRLQDQPFRSDGRVI----YCVNIIYWYIRLLD 833
Query: 556 ILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
I N+ GP + +G+ + D+ F+++ ++V +F + + L ++ +
Sbjct: 834 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI----LFPNEEPSWKLAK 889
Query: 616 ESFKTLFWSIFGLSEVTSV-------VLKYDHKFIEN--------IGYVLYGIYNVTMVV 660
F +W I+G + + D K I+ I + Y + +
Sbjct: 890 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANI 949
Query: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPP 706
+L+N+LIA+ N+++ E++ S+ WKF R +L ++ F + LPPP
Sbjct: 950 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVLPPP 994
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/103 (18%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 568 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG 627
I LGR + + + ++ + IG +L++Y + K+ + + +E + G
Sbjct: 703 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME-RWPSTQEWIVISYIFTLG 761
Query: 628 LSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMI 670
+ ++ +++ K ++ + L +NVT ++ +L + MI
Sbjct: 762 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 804
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 56.6 bits (135), Expect = 9e-08
Identities = 48/226 (21%), Positives = 102/226 (45%), Gaps = 25/226 (11%)
Query: 496 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 555
K + ++ Y +DL + L + +D+ SD ++I Y + ++ + R+
Sbjct: 769 KVKVWLQEYWNVTDLIAILLF-SVGMILRLQDQPFRSDGRVI----YCVNIIYWYIRLLD 823
Query: 556 ILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
I N+ GP + +G+ + D+ F+++ ++V +F + + L ++ +
Sbjct: 824 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI----LFPNEEPSWKLAK 879
Query: 616 ESFKTLFWSIFGLSEVTSV-------VLKYDHKFIEN--------IGYVLYGIYNVTMVV 660
F +W I+G + + D K I+ I + Y + +
Sbjct: 880 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANI 939
Query: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPP 706
+L+N+LIA+ N+++ E++ S+ WKF R +L ++ F + LPPP
Sbjct: 940 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVLPPP 984
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/103 (18%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 568 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG 627
I LGR + + + ++ + IG +L++Y + K+ + + +E + G
Sbjct: 693 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME-RWPSTQEWIVISYIFTLG 751
Query: 628 LSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMI 670
+ ++ +++ K ++ + L +NVT ++ +L + MI
Sbjct: 752 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 794
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 56.6 bits (135), Expect = 9e-08
Identities = 48/226 (21%), Positives = 102/226 (45%), Gaps = 25/226 (11%)
Query: 496 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 555
K + ++ Y +DL + L + +D+ SD ++I Y + ++ + R+
Sbjct: 781 KVKVWLQEYWNVTDLIAILLF-SVGMILRLQDQPFRSDGRVI----YCVNIIYWYIRLLD 835
Query: 556 ILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
I N+ GP + +G+ + D+ F+++ ++V +F + + L ++ +
Sbjct: 836 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI----LFPNEEPSWKLAK 891
Query: 616 ESFKTLFWSIFGLSEVTSV-------VLKYDHKFIEN--------IGYVLYGIYNVTMVV 660
F +W I+G + + D K I+ I + Y + +
Sbjct: 892 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANI 951
Query: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPP 706
+L+N+LIA+ N+++ E++ S+ WKF R +L ++ F + LPPP
Sbjct: 952 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVLPPP 996
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/103 (18%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 568 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG 627
I LGR + + + ++ + IG +L++Y + K+ + + +E + G
Sbjct: 705 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME-RWPSTQEWIVISYIFTLG 763
Query: 628 LSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMI 670
+ ++ +++ K ++ + L +NVT ++ +L + MI
Sbjct: 764 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 806
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,269,590
Number of Sequences: 37866
Number of extensions: 1228803
Number of successful extensions: 4168
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 3723
Number of HSP's gapped (non-prelim): 439
length of query: 848
length of database: 18,247,518
effective HSP length: 111
effective length of query: 737
effective length of database: 14,044,392
effective search space: 10350716904
effective search space used: 10350716904
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.