Search of human proteins with 4507229

Search of human proteins with 4507229

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
         (535 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ...  1071   0.0  
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo...  1062   0.0  
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]       286   4e-77
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap...   277   2e-74
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]       274   2e-73
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa...   269   4e-72
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]                268   9e-72
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]                 261   9e-70
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]                261   1e-69
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]       259   6e-69
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho...   257   2e-68
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]       253   4e-67
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]       229   6e-60
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]       228   8e-60
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]       198   9e-51
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa...   179   4e-45
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform...   146   4e-35
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]                 136   5e-32
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]                136   5e-32
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]                136   5e-32
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]                 135   1e-31
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]                 135   1e-31
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]       131   2e-30
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]        131   2e-30
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]       131   2e-30
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]      130   3e-30
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]        130   3e-30
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform...   102   9e-22
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...    98   2e-20
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]       98   2e-20

>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
           sapiens]
          Length = 535

 Score = 1072 bits (2771), Expect = 0.0
 Identities = 535/535 (100%), Positives = 535/535 (100%)

Query: 1   MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR 60
           MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
Sbjct: 1   MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR 60

Query: 61  TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120
           TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
Sbjct: 61  TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120

Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180
           SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
Sbjct: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180

Query: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240
           TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
Sbjct: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240

Query: 241 AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV 300
           AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV
Sbjct: 241 AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV 300

Query: 301 KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF 360
           KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF
Sbjct: 301 KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF 360

Query: 361 AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF 420
           AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF
Sbjct: 361 AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF 420

Query: 421 EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR 480
           EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR
Sbjct: 421 EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR 480

Query: 481 VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL 535
           VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
Sbjct: 481 VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL 535


>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
           sapiens]
          Length = 548

 Score = 1062 bits (2747), Expect = 0.0
 Identities = 535/548 (97%), Positives = 535/548 (97%), Gaps = 13/548 (2%)

Query: 1   MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR 60
           MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
Sbjct: 1   MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR 60

Query: 61  TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120
           TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
Sbjct: 61  TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120

Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180
           SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
Sbjct: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180

Query: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240
           TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
Sbjct: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240

Query: 241 AE-------------LASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 287
           AE             LASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT
Sbjct: 241 AEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 300

Query: 288 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 347
           TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL
Sbjct: 301 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 360

Query: 348 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 407
           VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV
Sbjct: 361 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 420

Query: 408 TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467
           TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA
Sbjct: 421 TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 480

Query: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527
           GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL
Sbjct: 481 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 540

Query: 528 KYVCYGGL 535
           KYVCYGGL
Sbjct: 541 KYVCYGGL 548


>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
          Length = 487

 Score =  286 bits (731), Expect = 4e-77
 Identities = 170/483 (35%), Positives = 271/483 (56%), Gaps = 14/483 (2%)

Query: 57  ALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116
           ALL  ++F+ G++LP ++     DP++G     V + G  E  AAV+AA EAF  W   S
Sbjct: 6   ALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRS 65

Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175
            +ERS +L +  +L+ Q+ ++ A+  + + GK L  A   +I  S     +F+  +    
Sbjct: 66  PQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT 125

Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
            +             ++ P+GVA +I+PWN P  ++T K+  A+AAG TV+ KP+E T  
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185

Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295
           +A  L +L  +AG+P GV N++         VGEA+ + P V  ISFTGS  T + +   
Sbjct: 186 TAWMLCKLLDKAGVPPGVVNIV---FGTGPRVGEALVSHPEVPLISFTGSQPTAERITQL 242

Query: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355
           +A   K++S+ELGG  P I+F+ AN+D+ +   + S F N G+ C+C+++  VQ+ I+  
Sbjct: 243 SAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSE 302

Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG----- 410
           F+K F EA +K  +VG   +   + G LI++  +EKV   V  A+++GA +  G      
Sbjct: 303 FLKRFVEATRK-WKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKL 361

Query: 411 ---KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467
               R+Q G  F  PT++ ++  +  C  EE FGP+  V+ FD+EEE I  AN    GLA
Sbjct: 362 SLPARNQAGY-FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA 420

Query: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527
              +S +  ++ RVA++L+ G+V  N  LI  +  PFGG+K SG+GREG+K   D + E+
Sbjct: 421 ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI 480

Query: 528 KYV 530
           K +
Sbjct: 481 KTI 483


>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
           sapiens]
          Length = 902

 Score =  277 bits (708), Expect = 2e-74
 Identities = 176/480 (36%), Positives = 274/480 (57%), Gaps = 15/480 (3%)

Query: 64  FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKE 119
           F+GG ++ A  A T    +P  G+ +  V+   V +   AV AA +AF   RW ++SA++
Sbjct: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484

Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178
           R  L+ +  +LM Q++++LA I   ++G     A    +  S     +F+    ++ G  
Sbjct: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544

Query: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
           I    A+  R L L  K+P+GV  +I PWN+P  M++ K  A LAAG TVV+KPA+ TP 
Sbjct: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 604

Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK-ILLH 294
           +AL  AEL  +AGIP GV NV+P S      VG+ +   P V KI FTGST  GK I+  
Sbjct: 605 TALKFAELTLKAGIPKGVVNVLPGS---GSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661

Query: 295 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354
            A ++VK+VS+ELGG +P I+F   ++++AV   M+S F N G+ C+ + +  V+  IHD
Sbjct: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721

Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414
            FV+   E ++K ++VGN  +  T  GP  +   + K+ +     V +GAT+V GG +  
Sbjct: 722 EFVRRVVEEVRK-MKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP 780

Query: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF-DTEEEAI-AIANAADVGLAGYFYS 472
               FFEPT+  +V   M    EE+FGP+  + +F D + +A+ + ANA + GLA   ++
Sbjct: 781 RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT 840

Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532
           +D  +   V+++L+ G V VN    + V  PFGG KQSG G++  +  ++EYL +K V +
Sbjct: 841 RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF 900


>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
          Length = 518

 Score =  274 bits (700), Expect = 2e-73
 Identities = 174/481 (36%), Positives = 254/481 (52%), Gaps = 20/481 (4%)

Query: 61  TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
           T  F+   W  + +   FPV +PA+G  +  V +    +   AV+AA  AF     WR +
Sbjct: 38  TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 97

Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170
            A ER  LL K  +L+ +++  LA + +   GKP  +A      G I    ++  W    
Sbjct: 98  DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 153

Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230
           A +++G  I     D       +PIGV   I PWNFP  M   K+  AL  G TVV+KPA
Sbjct: 154 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 212

Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290
           E TP SAL +  L  +AG P GV N++P     A   G AI +   + KI+FTGST  GK
Sbjct: 213 EQTPLSALYMGALIKEAGFPPGVINILPGYGPTA---GAAIASHIGIDKIAFTGSTEVGK 269

Query: 291 ILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349
           ++   A  S +KRV++ELGG +P I+F  A++D AV  A    F N GQ C   ++  V+
Sbjct: 270 LIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVE 329

Query: 350 RGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409
             I++ FV+   E  K+ + VG+ F+  T QGP I++K   K+ + +   V++GA +  G
Sbjct: 330 ESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECG 388

Query: 410 GKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469
           GK       F EPT+  NVT DM    EE FGP+  +++F T +E I  AN +D GL   
Sbjct: 389 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAA 448

Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529
            ++ D  +   V+  ++ G V +N     + + PFGG K SG GRE  ++G+ EY E+K 
Sbjct: 449 VFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT 508

Query: 530 V 530
           V
Sbjct: 509 V 509


>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
           sapiens]
          Length = 923

 Score =  269 bits (688), Expect = 4e-72
 Identities = 168/478 (35%), Positives = 267/478 (55%), Gaps = 15/478 (3%)

Query: 64  FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKE 119
           F+ G++  A    T+   +P  G+ +  V+   + +   AV AA +AF    W  ++A+E
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505

Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178
           R  L+ +  +L+ +N+++LA I   +SG     A    I  S     +F+    ++ G  
Sbjct: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565

Query: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
           I    A+  R L    K+P+GV A+I PWN+P  M+  K  A LAAG T+V+KPA+ TP 
Sbjct: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625

Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK-ILLH 294
           +AL  AEL+ +AG P GV N+IP S   A   G+ +   P + K+ FTGST  GK I+  
Sbjct: 626 TALKFAELSVKAGFPKGVINIIPGSGGIA---GQRLSEHPDIRKLGFTGSTPIGKQIMKS 682

Query: 295 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354
            A +++K+VS+ELGG +P I+F+   +D+AV   M + F N G+ C+ + +  V+  IHD
Sbjct: 683 CAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHD 742

Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414
            FV    E +KK +++G+  +  T  GP  ++  +EK+ +     V +GAT+V GG++ Q
Sbjct: 743 EFVTRVVEEIKK-MKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQ 801

Query: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTE--EEAIAIANAADVGLAGYFYS 472
               F EPT+  +V   M    EE+FGP+  + KF     +  +  AN+ + GLA   ++
Sbjct: 802 RPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFT 861

Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
           +D  +   V+E+LE G V +N    + V  PFGGVKQSG G++  +  ++EYL+ K V
Sbjct: 862 RDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTV 919


>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
          Length = 518

 Score =  268 bits (685), Expect = 9e-72
 Identities = 160/466 (34%), Positives = 251/466 (53%), Gaps = 12/466 (2%)

Query: 72  AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLM 131
           A+ T    +PA+G  +      G +E   AV+ A  AF  W + S  ER  +L +   ++
Sbjct: 49  ASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 108

Query: 132 IQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVL 191
            + +D++A +    +GK + EA  +I  S   LE+++  A  + G+ I  P         
Sbjct: 109 REREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSF-GYTR 167

Query: 192 KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPS 251
           ++P+GV   I  WN+P  + + K   ALA G  +V KP+  TP SAL LAE+ S+AG+P 
Sbjct: 168 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPP 227

Query: 252 GVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLA 311
           G++NV+    +     G+ +C  P V+K+SFTGS  TG  ++  +A  +K V++ELGG +
Sbjct: 228 GLFNVV----QGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 283

Query: 312 PFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVG 371
           P I+F   +++ AV GA+ + F   GQ C    +  VQ+ I D F +   +  ++ +++G
Sbjct: 284 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQR-IKIG 342

Query: 372 NGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH-----QLGKNFF-EPTLL 425
           +   E T  GPLIN   +E+V   V  A  +GA V+ GG  +     +L   ++  P +L
Sbjct: 343 DPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVL 402

Query: 426 CNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL 485
            N   DM C  EE FGP+  ++ FDTE E +  AN    GLA   +++D  +  RV  +L
Sbjct: 403 TNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAEL 462

Query: 486 EVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531
           + G   +N   +S VE PFGG K+SG GRE  +  I+ Y +LK VC
Sbjct: 463 QAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 508


>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
          Length = 501

 Score =  261 bits (668), Expect = 9e-70
 Identities = 170/477 (35%), Positives = 253/477 (53%), Gaps = 12/477 (2%)

Query: 61  TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREV 115
           T  F+   W  + +   FPV +PA+   L  V +    +   AV+AA +AF     WR +
Sbjct: 21  TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80

Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174
            A ER  LL K  +L+ +++  LA + +   GK    A+   L      L + +  A ++
Sbjct: 81  DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140

Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234
            G  I     +       +PIGV   I PWNFP  M+  K+G AL+ G TVVVKPAE TP
Sbjct: 141 QGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199

Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294
            +AL +A L  +AG P GV N++P     A   G AI +   + K++FTGST  GK++  
Sbjct: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTA---GAAISSHMDIDKVAFTGSTEVGKLIKE 256

Query: 295 HAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353
            A  S +KRV++ELGG +P IV   A++D AV  A    F + GQ C+ +++  V+  I+
Sbjct: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316

Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413
           D FV+   E  KK + +GN    G TQGP I+++  +K+   +     +GA +  GG   
Sbjct: 317 DEFVRRSVERAKKYI-LGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375

Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473
                F +PT+  NVT +M    EE FGP+  ++KF + ++ I  AN    GL+   +++
Sbjct: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435

Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
           D  +   ++  L+ G V VN   + S +CPFGG K SG GRE  +YG  EY E+K V
Sbjct: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492


>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
          Length = 512

 Score =  261 bits (666), Expect = 1e-69
 Identities = 170/478 (35%), Positives = 253/478 (52%), Gaps = 14/478 (2%)

Query: 61  TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
           T  F+   W  + +   F   +P++   +  V +    +   AV AA  AF R   WR +
Sbjct: 32  TKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRL 91

Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174
            A  R  LL +  +L+ +++  LA + T ++GKP   A    L      L +F+  A ++
Sbjct: 92  DALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKI 151

Query: 175 YGDIIHTPAKDRRALVLK-QPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233
            G  I  P  D      + +PIGV   ITPWNFP  M+  K+  AL  G T+V+KPAE T
Sbjct: 152 QGKTI--PTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQT 209

Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293
           P +AL L  L  +AG P GV N++P        VG AI + P ++KI+FTGST  GK++ 
Sbjct: 210 PLTALYLGSLIKEAGFPPGVVNIVPGF---GPTVGAAISSHPQINKIAFTGSTEVGKLVK 266

Query: 294 HHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352
             A+ S +KRV++ELGG  P IV   A++D AV  A    F N GQ C  +++  V+  +
Sbjct: 267 EAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQV 326

Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412
           +  FV+   E  KK   VG+ F+  T QGP I++K  +K+ + +     +GA +  GG  
Sbjct: 327 YSEFVRRSVEYAKKR-PVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSA 385

Query: 413 HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472
            +    F +PT+   VT +M    EE FGP+ P++KF + EE I  AN+ D GL    ++
Sbjct: 386 MEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFT 445

Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
           ++  +  ++A  LE G V +N       + PFGG K SG GRE  +Y + EY E+K V
Sbjct: 446 KNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTV 503


>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
          Length = 517

 Score =  259 bits (661), Expect = 6e-69
 Identities = 170/474 (35%), Positives = 251/474 (52%), Gaps = 12/474 (2%)

Query: 64  FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118
           F+   W  A +  TFP  +P +G  +G VA+    +   AV+AA EAF     WR + A 
Sbjct: 40  FINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDAS 99

Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFL-EWFSEEARRVYGD 177
           ER  LL +  +L+ +++  LA + T ++GKP +E++   L     +  +F+  A + +G 
Sbjct: 100 ERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK 159

Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237
            I    +        +P+GV   I PWNFP  M   K+  ALA G TVV+K AE TP SA
Sbjct: 160 TIPMDGQ-HFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSA 218

Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297
           L LA L  +AG P GV N+I      A   G AI     V K++FTGST  G ++   A 
Sbjct: 219 LYLASLIKEAGFPPGVVNIITGYGPTA---GAAIAQHVDVDKVAFTGSTEVGHLIQKAAG 275

Query: 298 NS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356
           +S +KRV++ELGG +P IV   A+++ AV     + F N GQ C   ++  V+  I++ F
Sbjct: 276 DSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEF 335

Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416
           ++   E  K+  +VGN FE  T QGP ++++  E+V   +     +GA ++ GG+R    
Sbjct: 336 LERTVEKAKQR-KVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGER 394

Query: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476
             F +PT+   V  DM    EE FGP+ P+ KF   EE +  AN    GLA   +++D  
Sbjct: 395 GFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLD 454

Query: 477 QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
           +     + L+ G V VN   I +   PFGG K+SG GRE  + G+  Y E+K V
Sbjct: 455 KAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTV 508


>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
           sapiens]
          Length = 517

 Score =  257 bits (656), Expect = 2e-68
 Identities = 167/474 (35%), Positives = 254/474 (53%), Gaps = 12/474 (2%)

Query: 64  FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118
           F+   W  A +  TFP  +P++G  +  VA+    +   AV+AA  AF     WR + A 
Sbjct: 40  FINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDAS 99

Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRVYGD 177
            R  LL +  +L+ +++  LA + T ++GKP   ++   L      L +++  A + +G 
Sbjct: 100 HRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK 159

Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237
            I     D  +    +P+GV   I PWNFP  M   K+G ALA G  VV+K AE TP +A
Sbjct: 160 TIPIDG-DFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTA 218

Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297
           L +A L  +AG P GV N++P     A   G AI +   V K++FTGST  G+++   A 
Sbjct: 219 LYVANLIKEAGFPPGVVNIVPGFGPTA---GAAIASHEDVDKVAFTGSTEIGRVIQVAAG 275

Query: 298 NS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356
           +S +KRV++ELGG +P I+   A++D AV  A  + F N GQ C   ++  VQ  I+D F
Sbjct: 276 SSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEF 335

Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416
           V+  + A  K+  VGN F+  T QGP ++E   +K+   +N    +GA ++ GG      
Sbjct: 336 VER-SVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR 394

Query: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476
             F +PT+  +V   M    EE FGP+  ++KF T EE +  AN +  GLA   +++D  
Sbjct: 395 GYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLD 454

Query: 477 QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
           +   +++ L+ G V VN   +   + PFGG K SG GRE  +YG+  Y E+K V
Sbjct: 455 KANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTV 508


>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
          Length = 422

 Score =  253 bits (645), Expect = 4e-67
 Identities = 156/422 (36%), Positives = 227/422 (53%), Gaps = 15/422 (3%)

Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSE 169
           + A ER  LL K  +L+ +++  LA + +   GKP  +A      G I    ++  W   
Sbjct: 1   MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW--- 57

Query: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229
            A +++G  I     D       +PIGV   I PWNFP  M   K+  AL  G TVV+KP
Sbjct: 58  -ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKP 115

Query: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289
           AE TP SAL +  L  +AG P GV N++P     A   G AI +   + KI+FTGST  G
Sbjct: 116 AEQTPLSALYMGALIKEAGFPPGVINILPGYGPTA---GAAIASHIGIDKIAFTGSTEVG 172

Query: 290 KILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLV 348
           K++   A  S +KRV++ELGG +P I+F  A++D AV  A    F N GQ C   ++  V
Sbjct: 173 KLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFV 232

Query: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408
           +  I++ FV+   E  K+ + VG+ F+  T QGP I++K   K+ + +   V++GA +  
Sbjct: 233 EESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLEC 291

Query: 409 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468
           GGK       F EPT+  NVT DM    EE FGP+  +++F T +E I  AN +D GL  
Sbjct: 292 GGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVA 351

Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528
             ++ D  +   V+  ++ G V +N     + + PFGG K SG GRE  ++G+ EY E+K
Sbjct: 352 AVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVK 411

Query: 529 YV 530
            V
Sbjct: 412 TV 413


>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
          Length = 433

 Score =  229 bits (583), Expect = 6e-60
 Identities = 153/475 (32%), Positives = 242/475 (50%), Gaps = 52/475 (10%)

Query: 57  ALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116
           ALL  ++F+ G++LP ++     DP++G     V + G  E  AAV+AA EAF  W   S
Sbjct: 6   ALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRS 65

Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175
            +ERS +L +  +L+ Q+ ++ A+  + + GK L  A   +I  S     +F+  +    
Sbjct: 66  PQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT 125

Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
            +             ++ P+GVA +I+PWN P  ++T K+  A+AAG TV+ KP+E T  
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185

Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295
           +A  L +L  +AG+P GV N++         VGEA+ + P V  ISFTGS  T + +   
Sbjct: 186 TAWMLCKLLDKAGVPPGVVNIV---FGTGPRVGEALVSHPEVPLISFTGSQPTAERITQL 242

Query: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355
           +A   K++S+ELGG  P I+F+ AN+D+ +   + S F N  ++ V              
Sbjct: 243 SAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYV-------------- 288

Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 415
             +A AE  +  +  G G               V+K+                   R+Q 
Sbjct: 289 -KRALAEGAQ--IWCGEG---------------VDKLSLPA---------------RNQA 315

Query: 416 GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDP 475
           G  F  PT++ ++  +  C  EE FGP+  V+ FD+EEE I  AN    GLA   +S + 
Sbjct: 316 G-YFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNV 374

Query: 476 AQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
            ++ RVA++L+ G+V  N  LI  +  PFGG+K SG+GREG+K   D + E+K +
Sbjct: 375 GRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTI 429


>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
          Length = 480

 Score =  228 bits (582), Expect = 8e-60
 Identities = 158/480 (32%), Positives = 234/480 (48%), Gaps = 56/480 (11%)

Query: 61  TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
           T  F+   W  + +   FPV +PA+G  +  V +    +   AV+AA  AF     WR +
Sbjct: 38  TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 97

Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170
            A ER  LL K  +L+ +++  LA + +   GKP  +A      G I    ++  W    
Sbjct: 98  DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 153

Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230
           A +++G  I     D       +PIGV   I PWNFP  M   K+  AL  G TVV+KPA
Sbjct: 154 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 212

Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290
           E TP SAL +  L                     KEVG+ I                 G+
Sbjct: 213 EQTPLSALYMGALI--------------------KEVGKLI-------------QEAAGR 239

Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350
                  +++KRV++ELGG +P I+F  A++D AV  A    F N GQ C   ++  V+ 
Sbjct: 240 -------SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 292

Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410
            I++ FV+   E  K+ + VG+ F+  T QGP I++K   K+ + +   V++GA +  GG
Sbjct: 293 SIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG 351

Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470
           K       F EPT+  NVT DM    EE FGP+  +++F T +E I  AN +D GL    
Sbjct: 352 KGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAV 411

Query: 471 YSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
           ++ D  +   V+  ++ G V +N     + + PFGG K SG GRE  ++G+ EY E+K V
Sbjct: 412 FTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTV 471


>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
          Length = 535

 Score =  198 bits (504), Expect = 9e-51
 Identities = 138/489 (28%), Positives = 231/489 (47%), Gaps = 17/489 (3%)

Query: 52  AGLSAALLRTDSFVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAF 109
           +  S+++     F+GG+++ + +     + +PA+   +G V      E  AA+ +   AF
Sbjct: 31  SSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAF 90

Query: 110 CRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE 169
             W + S   R  +L ++  L+ +N  ++A++IT E GK L +A G++      +E    
Sbjct: 91  PAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACS 150

Query: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229
               + G+ + +  KD      + P+GV A I P+NFP+ +       A+  G T ++KP
Sbjct: 151 VTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKP 210

Query: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289
           +E  P + + LA+L   +G P G  N+I        E    IC  P +  ISF GS   G
Sbjct: 211 SERVPGATMLLAKLLQDSGAPDGTLNII----HGQHEAVNFICDHPDIKAISFVGSNKAG 266

Query: 290 KILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVC-SNQFLV 348
           + +    +   KRV   +G     +V   AN +  +   + + F   GQ C+  S   LV
Sbjct: 267 EYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLV 326

Query: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408
             G    ++    E   KNLRV  G + G   GPLI  +A E+V   ++    +GA+++ 
Sbjct: 327 --GEAKKWLPELVE-HAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILL 383

Query: 409 GGKRHQL----GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV 464
            G++ ++      NF  PT++ NV  +M C  EE FGP+  V++ +T +EAI I N    
Sbjct: 384 DGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPY 443

Query: 465 GLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQSGLGREG--SKYGI 521
           G     ++ + A   + A  ++VG VGVN  + +      F G + S  G      K GI
Sbjct: 444 GNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGI 503

Query: 522 DEYLELKYV 530
             Y +LK +
Sbjct: 504 QFYTQLKTI 512


>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
           sapiens]
          Length = 539

 Score =  179 bits (455), Expect = 4e-45
 Identities = 133/498 (26%), Positives = 220/498 (44%), Gaps = 6/498 (1%)

Query: 33  PASGPAPGPAQLRCYAGRLAGLSAALLRTDS--FVGGRWLPAAATFPVQDPASGAALGMV 90
           P S PA   + L     + A L    LR ++     G W           PA+   +  V
Sbjct: 21  PWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARV 80

Query: 91  ADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPL 150
               V +    V+ A EA+  W ++ A +R  ++R+  + + +    L  +++ E GK L
Sbjct: 81  RQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKIL 140

Query: 151 KEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAM 210
            E  GE+       ++    +R + G I+ +       +    P+G+  +IT +NFP A+
Sbjct: 141 VEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAV 200

Query: 211 ITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEA 270
                  A+  G   + K A  T   ++A+ ++ ++    + +   I        ++G A
Sbjct: 201 YGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTA 260

Query: 271 ICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA 330
           +  D  V+ +SFTGST  GK +         R  +ELGG    I F+ A++   V  A+ 
Sbjct: 261 MAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALF 320

Query: 331 SKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVE 390
           +     GQ C  + +  +   IHD  V    +A  + +RVGN ++     GPL  ++AV 
Sbjct: 321 AAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQ-IRVGNPWDPNVLYGPLHTKQAVS 379

Query: 391 KVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFD 450
                V +A  +G TVV GGK      N+ EPT++  +  D    H ETF P+  V KF 
Sbjct: 380 MFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFK 439

Query: 451 TEEEAIAIANAADVGLAGYFYSQDPAQI--WRVAEQLEVGMVGVNEGLI-SSVECPFGGV 507
            EEE  A  N    GL+   +++D  +I  W   +  + G+V VN     + +   FGG 
Sbjct: 440 NEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGE 499

Query: 508 KQSGLGREGSKYGIDEYL 525
           K +G GRE       +Y+
Sbjct: 500 KHTGGGRESGSDAWKQYM 517


>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
           [Homo sapiens]
          Length = 802

 Score =  146 bits (369), Expect = 4e-35
 Identities = 134/508 (26%), Positives = 220/508 (43%), Gaps = 32/508 (6%)

Query: 23  RLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQD 80
           R  PRA  +  +    P P    C    LA L         +V G+WL      + P QD
Sbjct: 5   RAGPRAREIFTSLEYGPVPESHAC---ALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQD 61

Query: 81  PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR 140
           P +G  L         +  AAV AA  AF  W       R+  L +   ++ +++  L  
Sbjct: 62  PITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWT 121

Query: 141 IITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199
           + +  +G+ ++E   G++  +   L + + +A           +    AL   +P+GV  
Sbjct: 122 LESLVTGRAVREVRDGDVQLAQQLLHYHAIQA-----------STQEEALAGWEPMGVIG 170

Query: 200 VITPWNFPSAMITRKVGAALAAGCTVV--VKPAEDTPFSALALAELASQAGIPSGVYNVI 257
           +I P  F    +  ++  ALA GCTVV  V PA   P   L LA+LA + G   G+ NV+
Sbjct: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---LLLAQLAGELGPFPGILNVL 227

Query: 258 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFD 317
                    +   + + P + K++F G+   G+ L    A     + + LG  +  ++ D
Sbjct: 228 ----SGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTD 283

Query: 318 SANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEG 377
           +A+VD AV G + + + + G   +   + L+Q  + D  ++   E M + LR G G +  
Sbjct: 284 TADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDEAMRRLQERMGR-LRSGRGLDGA 339

Query: 378 TTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHE 437
              G      A + V++ V +A S+GA V   G      + F+ PTL+ N+     C   
Sbjct: 340 VDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPS-ERPFYPPTLVSNLPPASPCAQV 397

Query: 438 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLI 497
           E   P+     F T +EA+ +AN    G +   +S+   Q   +   L+VG V +N   +
Sbjct: 398 EVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGL 457

Query: 498 SSVECPFGGVKQSGLGREGSKYGIDEYL 525
                P GG K+SG    G   G+ EYL
Sbjct: 458 RDPSVPTGGCKESGCSWHGGPDGLYEYL 485



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 78/281 (27%), Positives = 121/281 (43%), Gaps = 28/281 (9%)

Query: 5   IWLRSCGARRL-----GSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALL 59
           +W+ + G R       G    GC       GL     P+  PA+L C +  L   +  L 
Sbjct: 450 VWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLA 509

Query: 60  RTDS-----------------FVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARA 100
              +                 FVGGR+    A ++ P++D +SG   G VA+ G ++ R 
Sbjct: 510 VPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGGAKDIRG 568

Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160
           AV AA++AF  W   S   R++LL      + + K  LA  +  + G  LK A  E+  S
Sbjct: 569 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQ-GAELKAAEAEVELS 627

Query: 161 AFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220
           A  L  +    +   G  +         L L++P+GV AV+ P  +P       +  ALA
Sbjct: 628 ARRLRAWGARVQ-AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALA 686

Query: 221 AGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSR 261
            G TVV+ P+   P  AL + +  +    P+G+ NV+   R
Sbjct: 687 YGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDR 726


>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  136 bits (342), Expect = 5e-32
 Identities = 120/432 (27%), Positives = 197/432 (45%), Gaps = 24/432 (5%)

Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159
           AV+ A  AF   R    + R   L     L+ + + +L   + A+  K    A+  E++Y
Sbjct: 7   AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66

Query: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216
               +E+  ++      D  +  TP   +  L +  +P+GV  VI  WN+P  +  + + 
Sbjct: 67  VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126

Query: 217 AALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 276
            A+AAG +VV+KP+E +   A  LA +  Q  +   +Y VI        E+         
Sbjct: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL-----LKER 180

Query: 277 VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 336
              I +TGST  GKI++  AA  +  V++ELGG +P  V  + ++D A       KF N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQGPLINEKAVEKVEK 394
           GQTCV  +  L    I +  V    E +KK+L+   G   ++    G +I+ +  ++V  
Sbjct: 241 GQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVM- 295

Query: 395 QVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 454
                + +G  V  GG        +  PT+L +V        EE FGP+ P++   + EE
Sbjct: 296 ----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350

Query: 455 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGL 512
           AI   N  +  LA Y +S +   I ++  +   G V  N+ +  I+    PFGGV  SG+
Sbjct: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410

Query: 513 GREGSKYGIDEY 524
           G    K   + +
Sbjct: 411 GSYHGKKSFETF 422


>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  136 bits (342), Expect = 5e-32
 Identities = 120/432 (27%), Positives = 197/432 (45%), Gaps = 24/432 (5%)

Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159
           AV+ A  AF   R    + R   L     L+ + + +L   + A+  K    A+  E++Y
Sbjct: 7   AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66

Query: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216
               +E+  ++      D  +  TP   +  L +  +P+GV  VI  WN+P  +  + + 
Sbjct: 67  VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126

Query: 217 AALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 276
            A+AAG +VV+KP+E +   A  LA +  Q  +   +Y VI        E+         
Sbjct: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL-----LKER 180

Query: 277 VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 336
              I +TGST  GKI++  AA  +  V++ELGG +P  V  + ++D A       KF N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQGPLINEKAVEKVEK 394
           GQTCV  +  L    I +  V    E +KK+L+   G   ++    G +I+ +  ++V  
Sbjct: 241 GQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVM- 295

Query: 395 QVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 454
                + +G  V  GG        +  PT+L +V        EE FGP+ P++   + EE
Sbjct: 296 ----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350

Query: 455 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGL 512
           AI   N  +  LA Y +S +   I ++  +   G V  N+ +  I+    PFGGV  SG+
Sbjct: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410

Query: 513 GREGSKYGIDEY 524
           G    K   + +
Sbjct: 411 GSYHGKKSFETF 422


>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  136 bits (342), Expect = 5e-32
 Identities = 120/432 (27%), Positives = 197/432 (45%), Gaps = 24/432 (5%)

Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159
           AV+ A  AF   R    + R   L     L+ + + +L   + A+  K    A+  E++Y
Sbjct: 7   AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66

Query: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216
               +E+  ++      D  +  TP   +  L +  +P+GV  VI  WN+P  +  + + 
Sbjct: 67  VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126

Query: 217 AALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 276
            A+AAG +VV+KP+E +   A  LA +  Q  +   +Y VI        E+         
Sbjct: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL-----LKER 180

Query: 277 VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 336
              I +TGST  GKI++  AA  +  V++ELGG +P  V  + ++D A       KF N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQGPLINEKAVEKVEK 394
           GQTCV  +  L    I +  V    E +KK+L+   G   ++    G +I+ +  ++V  
Sbjct: 241 GQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVM- 295

Query: 395 QVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 454
                + +G  V  GG        +  PT+L +V        EE FGP+ P++   + EE
Sbjct: 296 ----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350

Query: 455 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGL 512
           AI   N  +  LA Y +S +   I ++  +   G V  N+ +  I+    PFGGV  SG+
Sbjct: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410

Query: 513 GREGSKYGIDEY 524
           G    K   + +
Sbjct: 411 GSYHGKKSFETF 422


>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score =  135 bits (339), Expect = 1e-31
 Identities = 100/338 (29%), Positives = 166/338 (49%), Gaps = 18/338 (5%)

Query: 190 VLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGI 249
           + K+P G+  +I PWN+P  +    +  ALAAG  VV+KP+E +  +   LAE+  Q  +
Sbjct: 19  IWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-L 77

Query: 250 PSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGG 309
               + V+       +E G+ +  +  +  I FTGS   GKI++  A   +  V++ELGG
Sbjct: 78  DQSCFAVV---LGGPQETGQLL--EHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGG 132

Query: 310 LAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNL 368
             P  V D+ +  Q VA  +A   + N GQTCV  +  L    + +  + A    + +  
Sbjct: 133 KNPCYVDDNCD-PQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFY 191

Query: 369 RVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNV 428
             G+  +     G +IN+K  +++      A+     V  GG+ ++  + +  PT+L +V
Sbjct: 192 --GDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSNESDR-YIAPTVLVDV 243

Query: 429 TQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVG 488
            +      EE FGP+ P++   + +EAI   N  +  LA Y +S     + ++ E+   G
Sbjct: 244 QETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSG 303

Query: 489 MVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 524
             G NEG   IS +  PFGGV  SG+GR   K+  D +
Sbjct: 304 SFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTF 341


>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score =  135 bits (339), Expect = 1e-31
 Identities = 100/338 (29%), Positives = 166/338 (49%), Gaps = 18/338 (5%)

Query: 190 VLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGI 249
           + K+P G+  +I PWN+P  +    +  ALAAG  VV+KP+E +  +   LAE+  Q  +
Sbjct: 19  IWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-L 77

Query: 250 PSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGG 309
               + V+       +E G+ +  +  +  I FTGS   GKI++  A   +  V++ELGG
Sbjct: 78  DQSCFAVV---LGGPQETGQLL--EHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGG 132

Query: 310 LAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNL 368
             P  V D+ +  Q VA  +A   + N GQTCV  +  L    + +  + A    + +  
Sbjct: 133 KNPCYVDDNCD-PQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFY 191

Query: 369 RVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNV 428
             G+  +     G +IN+K  +++      A+     V  GG+ ++  + +  PT+L +V
Sbjct: 192 --GDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSNESDR-YIAPTVLVDV 243

Query: 429 TQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVG 488
            +      EE FGP+ P++   + +EAI   N  +  LA Y +S     + ++ E+   G
Sbjct: 244 QETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSG 303

Query: 489 MVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 524
             G NEG   IS +  PFGGV  SG+GR   K+  D +
Sbjct: 304 SFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTF 341


>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
          Length = 431

 Score =  131 bits (329), Expect = 2e-30
 Identities = 101/349 (28%), Positives = 165/349 (47%), Gaps = 18/349 (5%)

Query: 179 IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSAL 238
           +H   +   A + K+P G+  +I PWN+P  +    +  ALAAG  VV+KP+E +     
Sbjct: 52  LHKATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEK 111

Query: 239 ALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 298
            LAE+  Q  +    + V+       +E G+ +  +     I FTGS   GKI++  AA 
Sbjct: 112 ILAEVLPQY-VDQSCFAVV---LGGPQETGQLL--EHRFDYIFFTGSPRVGKIVMTAAAK 165

Query: 299 SVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDAFV 357
            +  V++ELGG  P  V D+ +  Q VA  +A  ++ N GQTCV  +  L    + +  +
Sbjct: 166 HLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL 224

Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417
            A    + +    G+  +     G +IN+K  +++      A+     V  GG+  +   
Sbjct: 225 PALQSTITR--FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSDE-SD 276

Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477
            +  PT+L +V +      EE FGP+ P++   + +EAI   N  +  LA Y +S     
Sbjct: 277 RYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQV 336

Query: 478 IWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 524
           + RV  Q   G    N+G   ++    PFGGV  SG+GR   K+  D +
Sbjct: 337 VKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 385


>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
          Length = 485

 Score =  131 bits (329), Expect = 2e-30
 Identities = 92/339 (27%), Positives = 160/339 (47%), Gaps = 16/339 (4%)

Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247
           A +  QP+GV  +I  WN+P  +  + +  A+AAG  V++KP+E +  +A  LA+L  Q 
Sbjct: 95  AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154

Query: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307
            +   +Y VI    +   E+            I +TG+T  GKI++  AA  +  V++EL
Sbjct: 155 -LDQDLYIVINGGVEETTEL-----LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLEL 208

Query: 308 GGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKN 367
           GG +P  +    ++D         K+ N GQTC+  +  L +  + +  V    E +K+ 
Sbjct: 209 GGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE- 267

Query: 368 LRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCN 427
              G   +E      +IN +  +++      ++ +G  +  GG+  +    +  PT+L +
Sbjct: 268 -FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE-ATRYIAPTVLTD 320

Query: 428 VTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEV 487
           V        EE FGP+ P++     +EAI   N  +  LA Y +S +   I R+ ++   
Sbjct: 321 VDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSS 380

Query: 488 GMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 524
           G V  N+ ++       PFGGV  SG+G    K+  D +
Sbjct: 381 GGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419


>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  131 bits (329), Expect = 2e-30
 Identities = 92/339 (27%), Positives = 160/339 (47%), Gaps = 16/339 (4%)

Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247
           A +  QP+GV  +I  WN+P  +  + +  A+AAG  V++KP+E +  +A  LA+L  Q 
Sbjct: 95  AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154

Query: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307
            +   +Y VI    +   E+            I +TG+T  GKI++  AA  +  V++EL
Sbjct: 155 -LDQDLYIVINGGVEETTEL-----LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLEL 208

Query: 308 GGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKN 367
           GG +P  +    ++D         K+ N GQTC+  +  L +  + +  V    E +K+ 
Sbjct: 209 GGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE- 267

Query: 368 LRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCN 427
              G   +E      +IN +  +++      ++ +G  +  GG+  +    +  PT+L +
Sbjct: 268 -FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE-ATRYIAPTVLTD 320

Query: 428 VTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEV 487
           V        EE FGP+ P++     +EAI   N  +  LA Y +S +   I R+ ++   
Sbjct: 321 VDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSS 380

Query: 488 GMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 524
           G V  N+ ++       PFGGV  SG+G    K+  D +
Sbjct: 381 GGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419


>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score =  130 bits (327), Expect = 3e-30
 Identities = 100/340 (29%), Positives = 162/340 (47%), Gaps = 18/340 (5%)

Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247
           A + K+P G+  +I PWN+P  +    +  ALAAG  VV+KP+E +      LAE+  Q 
Sbjct: 98  AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157

Query: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307
            +    + V+       +E G+ +  +     I FTGS   GKI++  AA  +  V++EL
Sbjct: 158 -VDQSCFAVV---LGGPQETGQLL--EHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLEL 211

Query: 308 GGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKK 366
           GG  P  V D+ +  Q VA  +A  ++ N GQTCV  +  L    + +  + A    + +
Sbjct: 212 GGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITR 270

Query: 367 NLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLC 426
               G+  +     G +IN+K  +++      A+     V  GG+  +    +  PT+L 
Sbjct: 271 --FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSDE-SDRYIAPTVLV 322

Query: 427 NVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLE 486
           +V +      EE FGP+ P++   + +EAI   N  +  LA Y +S     + RV  Q  
Sbjct: 323 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 382

Query: 487 VGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 524
            G    N+G   ++    PFGGV  SG+GR   K+  D +
Sbjct: 383 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422


>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score =  130 bits (327), Expect = 3e-30
 Identities = 100/340 (29%), Positives = 162/340 (47%), Gaps = 18/340 (5%)

Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247
           A + K+P G+  +I PWN+P  +    +  ALAAG  VV+KP+E +      LAE+  Q 
Sbjct: 98  AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157

Query: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307
            +    + V+       +E G+ +  +     I FTGS   GKI++  AA  +  V++EL
Sbjct: 158 -VDQSCFAVV---LGGPQETGQLL--EHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLEL 211

Query: 308 GGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKK 366
           GG  P  V D+ +  Q VA  +A  ++ N GQTCV  +  L    + +  + A    + +
Sbjct: 212 GGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITR 270

Query: 367 NLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLC 426
               G+  +     G +IN+K  +++      A+     V  GG+  +    +  PT+L 
Sbjct: 271 --FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSDE-SDRYIAPTVLV 322

Query: 427 NVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLE 486
           +V +      EE FGP+ P++   + +EAI   N  +  LA Y +S     + RV  Q  
Sbjct: 323 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 382

Query: 487 VGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 524
            G    N+G   ++    PFGGV  SG+GR   K+  D +
Sbjct: 383 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422


>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
           [Homo sapiens]
          Length = 751

 Score =  102 bits (254), Expect = 9e-22
 Identities = 127/511 (24%), Positives = 197/511 (38%), Gaps = 89/511 (17%)

Query: 23  RLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQD 80
           R  PRA  +  +    P P    C    LA L         +V G+WL      + P QD
Sbjct: 5   RAGPRAREIFTSLEYGPVPESHAC---ALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQD 61

Query: 81  PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR 140
           P +G  L         +  AAV AA  AF  W       R+  L +   ++ +++  L  
Sbjct: 62  PITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWT 121

Query: 141 IITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199
           + +  +G+ ++E   G++  +   L + + +A           +    AL   +P+GV  
Sbjct: 122 LESLVTGRAVREVRDGDVQLAQQLLHYHAIQA-----------STQEEALAGWEPMGVIG 170

Query: 200 VITPWNFPSAMITRKVGAALAAGCTVV--VKPAEDTPFSALALAELASQAGIPSGVYNVI 257
           +I P  F    +  ++  ALA GCTVV  V PA   P   L LA+LA + G   G+ NV+
Sbjct: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---LLLAQLAGELGPFPGILNVL 227

Query: 258 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA---NSVKRVSMELGGLAPFI 314
                    +   + + P + K++F G+   G  LL   +    +++R+   +G L    
Sbjct: 228 ----SGPASLVPILASQPGIRKVAFCGAPEGGLRLLIQESVWDEAMRRLQERMGRLRSGR 283

Query: 315 VFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGF 374
             D A VD    GA A                LVQR     FV+                
Sbjct: 284 GLDGA-VDMGARGAAACD--------------LVQR-----FVR---------------- 307

Query: 375 EEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLC 434
                                  +A S+GA V   G      + F+ PTL+ N+     C
Sbjct: 308 -----------------------EAQSQGAQVFQAGDVPS-ERPFYPPTLVSNLPPASPC 343

Query: 435 THEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNE 494
              E   P+     F T +EA+ +AN    G +   +S+   Q   +   L+VG V +N 
Sbjct: 344 AQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINA 403

Query: 495 GLISSVECPFGGVKQSGLGREGSKYGIDEYL 525
             +     P GG K+SG    G   G+ EYL
Sbjct: 404 HGLRDPSVPTGGCKESGCSWHGGPDGLYEYL 434



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 78/281 (27%), Positives = 121/281 (43%), Gaps = 28/281 (9%)

Query: 5   IWLRSCGARRL-----GSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALL 59
           +W+ + G R       G    GC       GL     P+  PA+L C +  L   +  L 
Sbjct: 399 VWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLA 458

Query: 60  RTDS-----------------FVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARA 100
              +                 FVGGR+    A ++ P++D +SG   G VA+ G ++ R 
Sbjct: 459 VPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGGAKDIRG 517

Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160
           AV AA++AF  W   S   R++LL      + + K  LA  +  + G  LK A  E+  S
Sbjct: 518 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQ-GAELKAAEAEVELS 576

Query: 161 AFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220
           A  L  +    +   G  +         L L++P+GV AV+ P  +P       +  ALA
Sbjct: 577 ARRLRAWGARVQ-AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALA 635

Query: 221 AGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSR 261
            G TVV+ P+   P  AL + +  +    P+G+ NV+   R
Sbjct: 636 YGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDR 675


>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 105/431 (24%), Positives = 192/431 (44%), Gaps = 28/431 (6%)

Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158
           A+ AA  A   W      +R+ +  K  +++   +  + LA+ +  + GK + +A  EI 
Sbjct: 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 161

Query: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215
            +A  +++F   A+    + G    +      + V +   G  A I+P+NF +A+     
Sbjct: 162 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 220

Query: 216 GAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDP 275
           GA    G  V+ KP++    ++ A+  +  +AG+P  +   +P    +    G+ + +  
Sbjct: 221 GAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA---DGPLFGDTVTSSE 277

Query: 276 LVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVFDSANVDQAVAGAM 329
            +  I+FTGS  T K L    A ++ R      ++ E GG     V  SA+V+  V+G +
Sbjct: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337

Query: 330 ASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE-GTTQGPLINEKA 388
            S F   GQ C   ++  V   +         E   + ++VG+  E+ GT    +I+ K+
Sbjct: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAEDFGTFFSAVIDAKS 396

Query: 389 VEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVI 447
             +++K +  A  S   T++ GGK       F EP ++ +         EE FGP+  V 
Sbjct: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456

Query: 448 KF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGMVGVNEGLISSV-- 500
            +  D  +E + + ++    GL G  +SQD   +    + L    G   +N+    S+  
Sbjct: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516

Query: 501 ECPFGGVKQSG 511
           + PFGG + SG
Sbjct: 517 QQPFGGARASG 527


>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
          Length = 503

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 105/431 (24%), Positives = 192/431 (44%), Gaps = 28/431 (6%)

Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158
           A+ AA  A   W      +R+ +  K  +++   +  + LA+ +  + GK + +A  EI 
Sbjct: 45  AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 101

Query: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215
            +A  +++F   A+    + G    +      + V +   G  A I+P+NF +A+     
Sbjct: 102 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 160

Query: 216 GAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDP 275
           GA    G  V+ KP++    ++ A+  +  +AG+P  +   +P    +    G+ + +  
Sbjct: 161 GAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA---DGPLFGDTVTSSE 217

Query: 276 LVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVFDSANVDQAVAGAM 329
            +  I+FTGS  T K L    A ++ R      ++ E GG     V  SA+V+  V+G +
Sbjct: 218 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 277

Query: 330 ASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE-GTTQGPLINEKA 388
            S F   GQ C   ++  V   +         E   + ++VG+  E+ GT    +I+ K+
Sbjct: 278 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAEDFGTFFSAVIDAKS 336

Query: 389 VEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVI 447
             +++K +  A  S   T++ GGK       F EP ++ +         EE FGP+  V 
Sbjct: 337 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 396

Query: 448 KF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGMVGVNEGLISSV-- 500
            +  D  +E + + ++    GL G  +SQD   +    + L    G   +N+    S+  
Sbjct: 397 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 456

Query: 501 ECPFGGVKQSG 511
           + PFGG + SG
Sbjct: 457 QQPFGGARASG 467


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,810,112
Number of Sequences: 37866
Number of extensions: 874612
Number of successful extensions: 2543
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 2393
Number of HSP's gapped (non-prelim): 59
length of query: 535
length of database: 18,247,518
effective HSP length: 107
effective length of query: 428
effective length of database: 14,195,856
effective search space: 6075826368
effective search space used: 6075826368
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.