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Search of human proteins with 4506309
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506309 protein tyrosine phosphatase, receptor type, D
isoform 1 precursor [Homo sapiens]
(1912 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 3872 0.0
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 3843 0.0
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 3834 0.0
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 2836 0.0
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 2796 0.0
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 2703 0.0
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 2690 0.0
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 1894 0.0
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 1888 0.0
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 1541 0.0
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 1541 0.0
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 602 e-171
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 601 e-171
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 601 e-171
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 556 e-158
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 550 e-156
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 509 e-144
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 503 e-142
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 495 e-139
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 490 e-138
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 459 e-129
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 454 e-127
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 449 e-126
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 448 e-125
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 424 e-118
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 3872 bits (10042), Expect = 0.0
Identities = 1912/1912 (100%), Positives = 1912/1912 (100%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
Sbjct: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
Query: 661 EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720
EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
Sbjct: 661 EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720
Query: 721 EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 780
EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT
Sbjct: 721 EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 780
Query: 781 TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 840
TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL
Sbjct: 781 TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 840
Query: 841 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 900
IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK
Sbjct: 841 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 900
Query: 901 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960
VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD
Sbjct: 901 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960
Query: 961 INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1020
INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF
Sbjct: 961 INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1020
Query: 1021 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1080
AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS
Sbjct: 1021 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1080
Query: 1081 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1140
YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY
Sbjct: 1081 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1140
Query: 1141 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1200
YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP
Sbjct: 1141 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1200
Query: 1201 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1260
TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI
Sbjct: 1201 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1260
Query: 1261 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1320
TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
Sbjct: 1261 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1320
Query: 1321 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1380
LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN
Sbjct: 1321 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1380
Query: 1381 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1440
KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
Sbjct: 1381 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1440
Query: 1441 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1500
RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL
Sbjct: 1441 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1500
Query: 1501 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1560
YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT
Sbjct: 1501 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1560
Query: 1561 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1620
GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
Sbjct: 1561 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1620
Query: 1621 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1680
PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP
Sbjct: 1621 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1680
Query: 1681 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1740
YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
Sbjct: 1681 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1740
Query: 1741 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1800
VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV
Sbjct: 1741 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1800
Query: 1801 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1860
RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV
Sbjct: 1801 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1860
Query: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912
LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 3843 bits (9965), Expect = 0.0
Identities = 1903/1912 (99%), Positives = 1903/1912 (99%), Gaps = 9/1912 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
Sbjct: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
Query: 661 EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720
EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
Sbjct: 661 EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720
Query: 721 EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 780
EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ
Sbjct: 721 EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ------ 774
Query: 781 TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 840
DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL
Sbjct: 775 ---DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 831
Query: 841 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 900
IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK
Sbjct: 832 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 891
Query: 901 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960
VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD
Sbjct: 892 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951
Query: 961 INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1020
INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF
Sbjct: 952 INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1011
Query: 1021 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1080
AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS
Sbjct: 1012 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1071
Query: 1081 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1140
YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY
Sbjct: 1072 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1131
Query: 1141 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1200
YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP
Sbjct: 1132 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1191
Query: 1201 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1260
TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI
Sbjct: 1192 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1251
Query: 1261 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1320
TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
Sbjct: 1252 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1311
Query: 1321 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1380
LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN
Sbjct: 1312 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1371
Query: 1381 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1440
KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
Sbjct: 1372 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1431
Query: 1441 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1500
RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL
Sbjct: 1432 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1491
Query: 1501 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1560
YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT
Sbjct: 1492 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1551
Query: 1561 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1620
GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
Sbjct: 1552 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1611
Query: 1621 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1680
PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP
Sbjct: 1612 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1671
Query: 1681 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1740
YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
Sbjct: 1672 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1731
Query: 1741 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1800
VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV
Sbjct: 1732 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1791
Query: 1801 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1860
RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV
Sbjct: 1792 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1851
Query: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912
LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1852 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 3834 bits (9942), Expect = 0.0
Identities = 1899/1912 (99%), Positives = 1899/1912 (99%), Gaps = 13/1912 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR VRRVPPRFSI
Sbjct: 181 ---------GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSI 227
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 228 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 287
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 288 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 347
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 348 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 408 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 467
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 468 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 527
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 528 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 587
Query: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
Sbjct: 588 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 647
Query: 661 EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720
EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
Sbjct: 648 EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 707
Query: 721 EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 780
EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT
Sbjct: 708 EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 767
Query: 781 TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 840
TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL
Sbjct: 768 TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 827
Query: 841 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 900
IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK
Sbjct: 828 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 887
Query: 901 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960
VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD
Sbjct: 888 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947
Query: 961 INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1020
INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF
Sbjct: 948 INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1007
Query: 1021 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1080
AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS
Sbjct: 1008 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1067
Query: 1081 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1140
YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY
Sbjct: 1068 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1127
Query: 1141 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1200
YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP
Sbjct: 1128 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1187
Query: 1201 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1260
TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI
Sbjct: 1188 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1247
Query: 1261 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1320
TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
Sbjct: 1248 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1307
Query: 1321 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1380
LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN
Sbjct: 1308 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1367
Query: 1381 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1440
KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
Sbjct: 1368 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1427
Query: 1441 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1500
RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL
Sbjct: 1428 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1487
Query: 1501 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1560
YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT
Sbjct: 1488 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1547
Query: 1561 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1620
GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
Sbjct: 1548 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1607
Query: 1621 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1680
PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP
Sbjct: 1608 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1667
Query: 1681 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1740
YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
Sbjct: 1668 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1727
Query: 1741 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1800
VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV
Sbjct: 1728 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1787
Query: 1801 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1860
RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV
Sbjct: 1788 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1847
Query: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912
LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1848 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 2836 bits (7353), Expect = 0.0
Identities = 1387/1924 (72%), Positives = 1609/1924 (83%), Gaps = 35/1924 (1%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSE+ TPIRGALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 209 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 269 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328
Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 329 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388
Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 389 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 449 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 509 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QSKPSAPPQD+ C
Sbjct: 569 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
Query: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
S ST+ILVSW+PPP E NG + YS++Y + ED +P E+ GIP TT+ LLE LEK
Sbjct: 629 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
Query: 680 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739
WT+YRIT AHT+VGPGPES V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 689 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
Query: 740 QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 799
QHGQIRGYQVHYVRME E +G P +KDVMLADAQWE DDT E++M+I+ LQPET+YS+T
Sbjct: 749 QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSIT 808
Query: 800 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRL 858
V AYT KGDGARSKPK+V T GAV G+P L + T + L +W PP T + GYRL
Sbjct: 809 VAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868
Query: 859 KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 918
+FGR+D PL TLEF ED +TA+ +HKGA+YVFRL+AR++ G GEE + +SIPE+ P
Sbjct: 869 QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTP 928
Query: 919 TGFPQNLHSEGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVP--- 974
G PQ L + G S +V L W PPV AERNG I KYT+ R+ L P + +P
Sbjct: 929 RGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG-ALGPARETELPAAA 987
Query: 975 ---ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1031
A+ +TL GLKPDT YD++VRAHT +GPGP+SP V++RT DQV KNF VK +MK
Sbjct: 988 EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMK 1047
Query: 1032 TSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNS 1091
TSVLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+S
Sbjct: 1048 TSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSS 1105
Query: 1092 AGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 1151
GGLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KSR
Sbjct: 1106 LGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSR 1165
Query: 1152 -GKFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDD 1208
G+F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD
Sbjct: 1166 GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQ 1225
Query: 1209 KHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLI 1268
K YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGLI
Sbjct: 1226 KQYGGFDNRGLEPGHRYVLFVLAVLQKSE-PTFAASPFSDPFQLDNPDPQPIVDGEEGLI 1284
Query: 1269 WVVGPVLAVVFIICIVIAILLYKR----KRAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1324
WV+GPVLAVVFIICIVIAILLYK KR +S+ R + NN ++ HHP DPVE+RR+
Sbjct: 1285 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1344
Query: 1325 NFQTP----------------GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ 1368
NFQTP M SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQ
Sbjct: 1345 NFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ 1404
Query: 1369 QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1428
QFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIAT
Sbjct: 1405 QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIAT 1464
Query: 1429 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTV 1488
QG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+
Sbjct: 1465 QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTI 1524
Query: 1489 ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1548
ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP
Sbjct: 1525 ELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGP 1584
Query: 1549 MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA 1608
+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+A
Sbjct: 1585 IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEA 1644
Query: 1609 LLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPC 1668
LLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPC
Sbjct: 1645 LLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPC 1704
Query: 1669 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1728
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
Sbjct: 1705 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1764
Query: 1729 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1788
WRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK
Sbjct: 1765 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1824
Query: 1789 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1848
VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV
Sbjct: 1825 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1884
Query: 1849 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD 1908
GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFD
Sbjct: 1885 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD 1944
Query: 1909 HYAT 1912
HYAT
Sbjct: 1945 HYAT 1948
Score = 183 bits (465), Expect = 1e-45
Identities = 218/906 (24%), Positives = 355/906 (39%), Gaps = 133/906 (14%)
Query: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 237 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288
Query: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 289 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339
Query: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
V E T T+ + SGNPDP ++++ IE
Sbjct: 340 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 366
Query: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
+S G Y+ + + TRYS + ++V + + + PP S+ E
Sbjct: 367 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 425
Query: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
P + N+ + + V+W E T E + P+G NV
Sbjct: 426 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 485
Query: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
+ + + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 486 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 545
Query: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 546 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 603
Query: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----T 456
+ V +T + PS+ P+DV+ + ST ILV W+ PE NG + GY V Y +
Sbjct: 604 AFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGS 663
Query: 457 MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP 516
DP N + + L Y + +A T +G GP SS + V T VP
Sbjct: 664 EDPEPKEVNGIPPTTTQILLEA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
Query: 517 -GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKDGEHGE------------- 558
P +AE + T+I + W P + I Y++ Y E E
Sbjct: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
Query: 559 EQRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDI 616
+ + + Y + L+P + Y +AA + +G GA + T + P +
Sbjct: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
Query: 617 SCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQ 676
T S+L W+PP ++ ++ Y +++ ED P L P +Y
Sbjct: 841 QQTPEG--SLLARWEPPAGTAEDQVL-GYRLQF---GREDSTPLATLEFPPSEDRYTASG 894
Query: 677 LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVSWRSP 735
+ K Y + A + G G E+ VL ED P G P+ +E ++ +V + W P
Sbjct: 895 VHKGATYVFRLAARSRGGLGEEAAEVL-SIPEDTPRGHPQILEAAGNASAGTVLLRWLPP 953
Query: 736 VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETS 795
VP +++G I Y V P + L + E+ + + GL+P+T+
Sbjct: 954 VPAERNGAIVKYTVAVREAGALGPARETELPAAA--------EPGAENALTLQGLKPDTA 1005
Query: 796 YSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQ 854
Y L V A+T +G G S P T P+ + + L+ W P D +
Sbjct: 1006 YDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFP-DNYNSPT 1064
Query: 855 GYRLKF 860
Y++++
Sbjct: 1065 PYKIQY 1070
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 2796 bits (7249), Expect = 0.0
Identities = 1373/1908 (71%), Positives = 1593/1908 (83%), Gaps = 41/1908 (2%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QSKPSAPPQD+ C
Sbjct: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 615
Query: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
S ST+ILVSW+PPP E NG + YS++Y + ED +P E+ GIP TT+ LLE LEK
Sbjct: 616 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 675
Query: 680 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739
WT+YRIT AHT+VGPGPES V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 676 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735
Query: 740 QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 799
QHGQIRGYQVHYVRME E +G P +KDVMLADAQ +M+I+ LQPET+YS+T
Sbjct: 736 QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ---------EMVITNLQPETAYSIT 786
Query: 800 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRL 858
V AYT KGDGARSKPK+V T GAV G+P L + T + L +W PP T + GYRL
Sbjct: 787 VAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 846
Query: 859 KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 918
+FGR+D PL TLEF ED +TA+ +HKGA+YVFRL+AR++ G GEE + +SIPE+ P
Sbjct: 847 QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTP 906
Query: 919 TGFPQNLHSEGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA-- 975
G PQ L + G S +V L W PPV AERNG I KYT+ R+ L P + +PA
Sbjct: 907 RGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA-LGPARETELPAAA 965
Query: 976 ----DTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1031
+ +TL GLKPDT YD++VRAHT +GPGP+SP V++RT DQV KNF VK +MK
Sbjct: 966 EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMK 1025
Query: 1032 TSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNS 1091
TSVLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+S
Sbjct: 1026 TSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSS 1083
Query: 1092 AGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 1151
GGLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KSR
Sbjct: 1084 LGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSR 1143
Query: 1152 G-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDD 1208
G +F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD
Sbjct: 1144 GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQ 1203
Query: 1209 KHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLI 1268
K YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGLI
Sbjct: 1204 KQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLI 1262
Query: 1269 WVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1324
WV+GPVLAVVFIICIVIAILLYK K R +S+ R + NN ++ HHP DPVE+RR+
Sbjct: 1263 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1322
Query: 1325 NFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKN 1384
NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKN
Sbjct: 1323 NFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKN 1382
Query: 1385 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1444
RYANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+W
Sbjct: 1383 RYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVW 1442
Query: 1445 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNG 1504
EQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNG
Sbjct: 1443 EQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG 1502
Query: 1505 SSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFI 1564
SSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFI
Sbjct: 1503 SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI 1562
Query: 1565 VIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARN 1624
VIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+
Sbjct: 1563 VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS 1622
Query: 1625 LYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1684
LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYEST
Sbjct: 1623 LYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1682
Query: 1685 RVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLT 1744
RVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLT
Sbjct: 1683 RVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLT 1742
Query: 1745 KLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1804
KLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ
Sbjct: 1743 KLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1802
Query: 1805 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1864
FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM
Sbjct: 1803 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1862
Query: 1865 RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912
RYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1863 RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 2703 bits (7006), Expect = 0.0
Identities = 1334/1910 (69%), Positives = 1567/1910 (82%), Gaps = 26/1910 (1%)
Query: 9 LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
L++L ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18 LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
Query: 69 FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
FEVIEFDDG+GSVLRIQPLR RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78 FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
Query: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188
DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS
Sbjct: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
Query: 189 RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248
GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR VRRV PRFSIPP++ E+M
Sbjct: 190 -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
Query: 249 PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308
PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 245 PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
Query: 309 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368
G+IEA AQ+TVKALPKPP VVTE+TATS+TLTWDSGN EPV+YY IQ++ +E ++
Sbjct: 305 GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
Query: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428
E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V +T EQAPSS PR VQARM
Sbjct: 365 EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
Query: 429 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488
LS++T+LVQW+ PEEPNG ++GYRVYYT D + N W KHN +TT+G+L+P TY
Sbjct: 425 LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
Query: 489 SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548
S++VLAFT++GDGP S IQV TQ GVP QP +F+AE ES+T I LSW P + I YE
Sbjct: 485 SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
Query: 549 LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
LVY E ++Q ++T +P +SY L+ LKP++LY F+LAARS G+G T I ART QS
Sbjct: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667
PSAPPQ + C S ST++ VSW PPP + +NG+IT+YS+ Y AVDGED H + GI
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
Query: 668 DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727
+ + + L LEKWTEYR+ V AHTDVGPGPES VL+RT+EDVPSGPPRKVEVE +NST+
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
Query: 728 VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMII 787
V V W+ PVP+KQHGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQW +++ +++ I
Sbjct: 725 VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI 784
Query: 788 SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV 847
SGL PET+YS+TV AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP
Sbjct: 785 SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK 844
Query: 848 DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM 907
+ G L GYRL++ R D T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE
Sbjct: 845 ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 904
Query: 908 VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 967
KEI PE++P+GFPQNLH G T+++ +L+W PPVLAERNG I YT+++RDIN
Sbjct: 905 EKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--- 961
Query: 968 MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVK 1027
E + DT TLTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V
Sbjct: 962 QELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVA 1021
Query: 1028 AVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN 1087
A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P YSFVL N
Sbjct: 1022 AAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMN 1079
Query: 1088 RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPL 1147
RG+SAGGLQH V+ +TAPD+L KP DG + +P V ++ +YI++VP+
Sbjct: 1080 RGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPI 1139
Query: 1148 KKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFT 1204
+ G + P W +P+E+ELDELL+ I + R R LKPY+AA DVLP FT
Sbjct: 1140 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFT 1199
Query: 1205 LGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDE 1263
LGD K+Y GF N+ L Y FVLA + E + K YA+SPYSD +V Q E
Sbjct: 1200 LGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QE 1257
Query: 1264 EEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELR 1322
E ++WV GPVLAV+ II IVIAILL+KRKR S S K K+ H +DPVE+R
Sbjct: 1258 EPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMR 1317
Query: 1323 RLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKP 1382
RLN+QTPGM HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKP
Sbjct: 1318 RLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKP 1377
Query: 1383 KNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRM 1442
KNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM
Sbjct: 1378 KNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRM 1437
Query: 1443 IWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK 1502
+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K
Sbjct: 1438 VWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK 1497
Query: 1503 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1562
+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGC
Sbjct: 1498 SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGC 1557
Query: 1563 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1622
FIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPA
Sbjct: 1558 FIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA 1617
Query: 1623 RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1682
RNLYA+IQKL Q+ GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE
Sbjct: 1618 RNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1677
Query: 1683 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM 1742
TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VM
Sbjct: 1678 LTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM 1737
Query: 1743 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ 1802
LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQ
Sbjct: 1738 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQ 1797
Query: 1803 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE 1862
FQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLE
Sbjct: 1798 FQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLE 1857
Query: 1863 RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912
RMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ YRAALEYLGSFDHYAT
Sbjct: 1858 RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 2690 bits (6972), Expect = 0.0
Identities = 1335/1910 (69%), Positives = 1563/1910 (81%), Gaps = 35/1910 (1%)
Query: 9 LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
L++L ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18 LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
Query: 69 FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
FEVIEFDDG+GSVLRIQPLR RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78 FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
Query: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188
DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS
Sbjct: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
Query: 189 RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248
GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR VRRV PRFSIPP++ E+M
Sbjct: 190 -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
Query: 249 PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308
PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 245 PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
Query: 309 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368
G+IEA AQ+TVKALPKPP VVTE+TATS+TLTWDSGN EPV+YY IQ++ +E ++
Sbjct: 305 GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
Query: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428
E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V +T EQAPSS PR VQARM
Sbjct: 365 EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
Query: 429 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488
LS++T+LVQW+ PEEPNG ++GYRVYYT D + N W KHN +TT+G+L+P TY
Sbjct: 425 LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
Query: 489 SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548
S++VLAFT++GDGP S IQV TQ GVP QP +F+AE ES+T I LSW P + I YE
Sbjct: 485 SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
Query: 549 LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
LVY E ++Q ++T +P +SY L+ LKP++LY F+LAARS G+G T I ART QS
Sbjct: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667
PSAPPQ + C S ST++ VSW PPP + +NG+IT+YS+ Y AVDGED H + GI
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
Query: 668 DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727
+ + + L LEKWTEYR+ V AHTDVGPGPES VL+RT+EDVPSGPPRKVEVE +NST+
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
Query: 728 VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMII 787
V V W+ PVP+KQHGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQ +TT I
Sbjct: 725 VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ----ETT-----I 775
Query: 788 SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV 847
SGL PET+YS+TV AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP
Sbjct: 776 SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK 835
Query: 848 DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM 907
+ G L GYRL++ R D T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE
Sbjct: 836 ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 895
Query: 908 VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 967
KEI PE++P+GFPQNLH G T+++ +L+W PPVLAERNG I YT+++RDIN
Sbjct: 896 EKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--- 952
Query: 968 MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVK 1027
E + DT TLTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V
Sbjct: 953 QELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVA 1012
Query: 1028 AVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN 1087
A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P YSFVL N
Sbjct: 1013 AAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMN 1070
Query: 1088 RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPL 1147
RG+SAGGLQH V+ +TAPD+L KP DG + +P V ++ +YI++VP+
Sbjct: 1071 RGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPI 1130
Query: 1148 KKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFT 1204
+ G + P W +P+E+ELDELL+ I + R R LKPY+AA DVLP FT
Sbjct: 1131 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFT 1190
Query: 1205 LGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDE 1263
LGD K+Y GF N+ L Y FVLA + E + K YA+SPYSD +V Q E
Sbjct: 1191 LGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QE 1248
Query: 1264 EEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELR 1322
E ++WV GPVLAV+ II IVIAILL+KRKR S S K K+ H +DPVE+R
Sbjct: 1249 EPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMR 1308
Query: 1323 RLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKP 1382
RLN+QTPGM HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKP
Sbjct: 1309 RLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKP 1368
Query: 1383 KNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRM 1442
KNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM
Sbjct: 1369 KNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRM 1428
Query: 1443 IWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK 1502
+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K
Sbjct: 1429 VWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK 1488
Query: 1503 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1562
+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGC
Sbjct: 1489 SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGC 1548
Query: 1563 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1622
FIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPA
Sbjct: 1549 FIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA 1608
Query: 1623 RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1682
RNLYA+IQKL Q+ GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE
Sbjct: 1609 RNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1668
Query: 1683 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM 1742
TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VM
Sbjct: 1669 LTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM 1728
Query: 1743 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ 1802
LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQ
Sbjct: 1729 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQ 1788
Query: 1803 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE 1862
FQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLE
Sbjct: 1789 FQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLE 1848
Query: 1863 RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912
RMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ YRAALEYLGSFDHYAT
Sbjct: 1849 RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 1894 bits (4905), Expect = 0.0
Identities = 967/1208 (80%), Positives = 1022/1208 (84%), Gaps = 40/1208 (3%)
Query: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
PP V +TS+ ++W S P V Y +++ + + K++
Sbjct: 325 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEI----- 370
Query: 774 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-I 831
D ++GL P + Y V A G G S+P L T+ P PR V
Sbjct: 371 ----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 426
Query: 832 NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGA 889
T L+QW P + G +QGYR+ + + + D T ++
Sbjct: 427 RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK 486
Query: 890 SYVFRLSARNKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 944
+Y ++ A +G G +++ + +P G P N +E + TS+ LSW PP
Sbjct: 487 TYSVKVLAFTSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP-- 539
Query: 945 AERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 1004
R+ I Y L+Y+D +++ + T+ L GLKP++ Y ++ A + +G G
Sbjct: 540 --RSDTIANYELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1005 YSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 1064
+ + RT+ +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD
Sbjct: 596 STAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 653
Query: 1065 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 1124
GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI
Sbjct: 654 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 713
Query: 1125 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 1184
TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR
Sbjct: 714 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 773
Query: 1185 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 1244
EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS
Sbjct: 774 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 833
Query: 1245 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 1304
PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI
Sbjct: 834 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 893
Query: 1305 PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI 1364
PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI
Sbjct: 894 PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI 953
Query: 1365 DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA 1424
DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA
Sbjct: 954 DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA 1013
Query: 1425 YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL 1484
YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL
Sbjct: 1014 YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL 1073
Query: 1485 LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1544
LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP
Sbjct: 1074 LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1133
Query: 1545 DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF 1604
DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF
Sbjct: 1134 DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF 1193
Query: 1605 IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA 1664
IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA
Sbjct: 1194 IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA 1253
Query: 1665 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1724
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET
Sbjct: 1254 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1313
Query: 1725 TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL 1784
TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL
Sbjct: 1314 TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL 1373
Query: 1785 REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1844
REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC
Sbjct: 1374 REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1433
Query: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1904
SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
Sbjct: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493
Query: 1905 GSFDHYAT 1912
GSFDHYAT
Sbjct: 1494 GSFDHYAT 1501
Score = 1226 bits (3172), Expect = 0.0
Identities = 613/633 (96%), Positives = 620/633 (97%), Gaps = 3/633 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
SARTMQS + ++ + TS+L+SW+ P
Sbjct: 601 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 630
Score = 130 bits (328), Expect = 9e-30
Identities = 126/437 (28%), Positives = 197/437 (45%), Gaps = 46/437 (10%)
Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
+ A S G+ + A+I+ + + P P T ++TSI ++W E + I
Sbjct: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 355
Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
++ K ++ EI G+ TT+Y + L +++Y V A ++G GP S V
Sbjct: 356 IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408
Query: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
L +T+E PS PR V+ ++ST++ V W+ P + +GQI+GY+V+Y M+ +
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 465
Query: 763 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 822
M +V AD+Q TT I L P+ +YS+ V A+T+ GDG S V T
Sbjct: 466 WMKHNV--ADSQ----ITT-----IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG 514
Query: 823 VPGKPRLVINHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKED 878
VPG+P + T+ L+ W PP DT + Y L K G E T+ E
Sbjct: 515 VPGQPLNFKAEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGT 568
Query: 879 HFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLS 938
+ + + Y FRL+AR+ G G EIS + + F +N H + TSV LS
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 626
Query: 939 WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 998
W+ P E + +LY D M + + T + LKP+ +Y V +
Sbjct: 627 WEIP---ENYNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNR 677
Query: 999 SKGPGPYSPSVQFRTLP 1015
G V +T P
Sbjct: 678 GNSAGGLQHRVTAKTAP 694
Score = 98.2 bits (243), Expect = 7e-20
Identities = 138/611 (22%), Positives = 239/611 (39%), Gaps = 92/611 (15%)
Query: 41 ASFICQATGDPRPKIVWNKKGKKV----SNQRFEVIEFDDGSGSVLR--IQPLRTPR-DE 93
A+ +C A+G+P P+I W K V +N R + + + G+ +R +Q ++ D+
Sbjct: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQ 202
Query: 94 AIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGN 152
YECVA+N+ G S L V ++ R P + P + + + C A G+
Sbjct: 203 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 262
Query: 153 PDPEITWF---KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVA 209
P P + W +D P D PI G +E ++ Y CVA
Sbjct: 263 PMPYVKWMLGAEDLTPEDDM-----------------PI-GRNVLELNDVRQSANYTCVA 304
Query: 210 TNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVK 268
++ G A A + V+ L + PP + + +IT G+P P
Sbjct: 305 MSTLGV-IEAIAQITVKALPK----------PPGTPVVTESTATSITLTWDSGNPEPVSY 353
Query: 269 WMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGT 328
+++ + P++ + + + D + Y+ +S E PP
Sbjct: 354 YIIQHK---PKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE 406
Query: 329 PVVTEST-----------------ATSITLTWDSGNPEP--------VSYYIIQHKPKNS 363
PV+T+++ +T+I + W EP V Y + + N+
Sbjct: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNN 465
Query: 364 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423
+ D TT + L P Y +V+A +IG GP S + T P P +
Sbjct: 466 WMKHNVADSQITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLN 521
Query: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483
+A S T+IL+ W P I Y + Y +H + + + L
Sbjct: 522 FKAEPESETSILLSWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLK 576
Query: 484 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-D 542
P Y ++ A + G G +++I T + + NF + +TS+LLSW P + +
Sbjct: 577 PNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYN 634
Query: 543 TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAE 599
+ ++++Y DG+ EE T + LKP Y F L R G TA+
Sbjct: 635 SAMPFKILYDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAK 691
Query: 600 ISARTMQSKPS 610
+ +++KP+
Sbjct: 692 TAPDVLRTKPA 702
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 1888 bits (4890), Expect = 0.0
Identities = 967/1212 (79%), Positives = 1022/1212 (84%), Gaps = 44/1212 (3%)
Query: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
PP V +TS+ ++W S P V Y +++ + + K++
Sbjct: 322 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEI----- 367
Query: 774 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-I 831
D ++GL P + Y V A G G S+P L T+ P PR V
Sbjct: 368 ----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 423
Query: 832 NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGA 889
T L+QW P + G +QGYR+ + + + D T ++
Sbjct: 424 RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK 483
Query: 890 SYVFRLSARNKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 944
+Y ++ A +G G +++ + +P G P N +E + TS+ LSW PP
Sbjct: 484 TYSVKVLAFTSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP-- 536
Query: 945 AERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 1004
R+ I Y L+Y+D +++ + T+ L GLKP++ Y ++ A + +G G
Sbjct: 537 --RSDTIANYELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 592
Query: 1005 YSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 1064
+ + RT+ +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD
Sbjct: 593 STAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 650
Query: 1065 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 1124
GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI
Sbjct: 651 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 710
Query: 1125 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 1184
TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR
Sbjct: 711 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 770
Query: 1185 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 1244
EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS
Sbjct: 771 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 830
Query: 1245 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK----RKRAESDSR 1300
PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK RKRAESDSR
Sbjct: 831 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSR 890
Query: 1301 KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE 1360
KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE
Sbjct: 891 KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE 950
Query: 1361 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR 1420
YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR
Sbjct: 951 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR 1010
Query: 1421 KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV 1480
KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV
Sbjct: 1011 KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV 1070
Query: 1481 QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT 1540
QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
Sbjct: 1071 QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT 1130
Query: 1541 CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED 1600
CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED
Sbjct: 1131 CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED 1190
Query: 1601 QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR 1660
QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR
Sbjct: 1191 QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR 1250
Query: 1661 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1720
FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP
Sbjct: 1251 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1310
Query: 1721 LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1780
LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP
Sbjct: 1311 LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1370
Query: 1781 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1840
QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI
Sbjct: 1371 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
Query: 1841 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1900
SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
Sbjct: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
Query: 1901 LEYLGSFDHYAT 1912
LEYLGSFDHYAT
Sbjct: 1491 LEYLGSFDHYAT 1502
Score = 1216 bits (3145), Expect = 0.0
Identities = 610/633 (96%), Positives = 617/633 (97%), Gaps = 6/633 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ---GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 237
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 238 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 297
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 298 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 357
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 358 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 417
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 418 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 477
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 478 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 537
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 538 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
Query: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
SARTMQS + ++ + TS+L+SW+ P
Sbjct: 598 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 627
Score = 130 bits (328), Expect = 9e-30
Identities = 126/437 (28%), Positives = 197/437 (45%), Gaps = 46/437 (10%)
Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
+ A S G+ + A+I+ + + P P T ++TSI ++W E + I
Sbjct: 297 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 352
Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
++ K ++ EI G+ TT+Y + L +++Y V A ++G GP S V
Sbjct: 353 IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
Query: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
L +T+E PS PR V+ ++ST++ V W+ P + +GQI+GY+V+Y M+ +
Sbjct: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 462
Query: 763 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 822
M +V AD+Q TT I L P+ +YS+ V A+T+ GDG S V T
Sbjct: 463 WMKHNV--ADSQ----ITT-----IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG 511
Query: 823 VPGKPRLVINHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKED 878
VPG+P + T+ L+ W PP DT + Y L K G E T+ E
Sbjct: 512 VPGQPLNFKAEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGT 565
Query: 879 HFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLS 938
+ + + Y FRL+AR+ G G EIS + + F +N H + TSV LS
Sbjct: 566 SYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 623
Query: 939 WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 998
W+ P E + +LY D M + + T + LKP+ +Y V +
Sbjct: 624 WEIP---ENYNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNR 674
Query: 999 SKGPGPYSPSVQFRTLP 1015
G V +T P
Sbjct: 675 GNSAGGLQHRVTAKTAP 691
Score = 97.8 bits (242), Expect = 9e-20
Identities = 138/609 (22%), Positives = 235/609 (38%), Gaps = 91/609 (14%)
Query: 41 ASFICQATGDPRPKIVWNKKGKKV--SNQRFEVIEFDDGSGSV---LRIQPLRTPRDEAI 95
A+ +C A+G+P P+I W K V SN + + G + L+I+ D+
Sbjct: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEES-DQGK 201
Query: 96 YECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPD 154
YECVA+N+ G S L V ++ R P + P + + + C A G+P
Sbjct: 202 YECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM 261
Query: 155 PEITWF---KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATN 211
P + W +D P D PI G +E ++ Y CVA +
Sbjct: 262 PYVKWMLGAEDLTPEDDM-----------------PI-GRNVLELNDVRQSANYTCVAMS 303
Query: 212 SAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVKWM 270
+ G A A + V+ L + PP + + +IT G+P P ++
Sbjct: 304 TLGV-IEAIAQITVKALPK----------PPGTPVVTESTATSITLTWDSGNPEPVSYYI 352
Query: 271 LGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPV 330
+ + P++ + + + D + Y+ +S E PP PV
Sbjct: 353 IQHK---PKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
Query: 331 VTEST-----------------ATSITLTWDSGNPEP--------VSYYIIQHKPKNSEE 365
+T+++ +T+I + W EP V Y + + N+
Sbjct: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWM 464
Query: 366 LYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQ 425
+ D TT + L P Y +V+A +IG GP S + T P P + +
Sbjct: 465 KHNVADSQITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFK 520
Query: 426 ARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQ 485
A S T+IL+ W P I Y + Y +H + + + L P
Sbjct: 521 AEPESETSILLSWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLKPN 575
Query: 486 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-DTI 544
Y ++ A + G G +++I T + + NF + +TS+LLSW P + ++
Sbjct: 576 SLYYFRLAARSPQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYNSA 633
Query: 545 ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAEIS 601
++++Y DG+ EE T + LKP Y F L R G TA+ +
Sbjct: 634 MPFKILYDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTA 690
Query: 602 ARTMQSKPS 610
+++KP+
Sbjct: 691 PDVLRTKPA 699
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 1541 bits (3989), Expect = 0.0
Identities = 798/1223 (65%), Positives = 939/1223 (76%), Gaps = 51/1223 (4%)
Query: 706 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 765
T + +P P + E +TS+ ++W S P+ + Y + Y ++ G +
Sbjct: 318 TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 369
Query: 766 KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 825
K+ D T I GL P + Y + V+A + G G S+ + T P
Sbjct: 370 KE-----------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA 418
Query: 826 K-PRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT 883
PR V T ++QW PV+ G ++GYR+ + + P+ + +D T
Sbjct: 419 SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT 478
Query: 884 --DIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQ 936
+ + +Y R+ A VG G +S P +V T G P NL +E + TS+
Sbjct: 479 VGSLLEDETYTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSIT 533
Query: 937 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 996
LSW PP R I KY LL+R+ + + + P T+ + LKP+T Y ++ A
Sbjct: 534 LSWSPP----RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAA 587
Query: 997 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1056
+ +G G ++P V+ RTL + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+
Sbjct: 588 RSPQGLGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 645
Query: 1057 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG 1116
+ +VDGR T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+
Sbjct: 646 --LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703
Query: 1117 KTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR 1175
K + DG I V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR
Sbjct: 704 KPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR 763
Query: 1176 -KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1233
+RRS+R+ R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV+
Sbjct: 764 LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL 823
Query: 1234 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK 1293
+ +E +A SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 824 QKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK 882
Query: 1294 ----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERL 1349
R +S+ R + NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERL
Sbjct: 883 PDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 942
Query: 1350 KANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSD 1409
KAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSD
Sbjct: 943 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 1002
Query: 1410 YVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW 1469
Y+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYW
Sbjct: 1003 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1062
Query: 1470 PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPT 1529
P+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PT
Sbjct: 1063 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1122
Query: 1530 PFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMR 1589
PFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR
Sbjct: 1123 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1182
Query: 1590 AQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFK 1649
+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFK
Sbjct: 1183 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1242
Query: 1650 RLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1709
RLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
Sbjct: 1243 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1302
Query: 1710 QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1769
QQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYF
Sbjct: 1303 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1362
Query: 1770 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1829
VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
Sbjct: 1363 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1422
Query: 1830 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1889
TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT
Sbjct: 1423 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1482
Query: 1890 EDQYQFSYRAALEYLGSFDHYAT 1912
ED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1483 EDEYQFCYQAALEYLGSFDHYAT 1505
Score = 902 bits (2331), Expect = 0.0
Identities = 448/669 (66%), Positives = 535/669 (79%), Gaps = 24/669 (3%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 259
Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 319
Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 320 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 379
Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 439
Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 440 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 499
Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 559
Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+Q S P++
Sbjct: 560 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVK 616
Query: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
TS+L+SW+ P + N T Y I+Y + L + TTK L+ L+
Sbjct: 617 MIMKTSVLLSWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKP 664
Query: 680 WTEYRITVT 688
T Y +T
Sbjct: 665 HTFYNFVLT 673
Score = 129 bits (325), Expect = 2e-29
Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 45/412 (10%)
Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
+ A S G+ + A+I+ +++ P P T ++TSI ++W + + +
Sbjct: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 355
Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
EY K D P++I TT+Y + L +EY I V+A +G GP S SV
Sbjct: 356 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 408
Query: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
+ RT E P+ PR V+ +++T++ V W PV + +G IRGY+V+Y ME P G
Sbjct: 409 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 465
Query: 763 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 822
+V DD+ + L + +Y++ V A+T+ GDG S P V T
Sbjct: 466 WQKHNV---------DDSLL--TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 514
Query: 823 VPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 881
VPG+P + + T++ + W PP + Y L F D F + +
Sbjct: 515 VPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYV 571
Query: 882 ATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSW 939
D+ Y FRL+AR+ G G +V++ ++ P F + TSV LSW
Sbjct: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSW 627
Query: 940 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 991
+ P + T Y + Y + + + T +T LKP T Y+
Sbjct: 628 EFP---DNYNSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 669
Score = 94.4 bits (233), Expect = 1e-18
Identities = 113/473 (23%), Positives = 188/473 (39%), Gaps = 90/473 (19%)
Query: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279
Query: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330
Query: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
V E T T+ + SGNPDP ++++ IE
Sbjct: 331 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 357
Query: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
+S G Y+ + + TRYS + ++V + + + PP S+ E
Sbjct: 358 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 416
Query: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
P + N+ + + V+W E T E + P+G NV
Sbjct: 417 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 476
Query: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
+ + + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 477 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 536
Query: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 537 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 594
Query: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 455
PV+ Q + Q S +P++ + +M+ T++L+ W+ P+ N Y++ Y
Sbjct: 595 -AFTPVVRQRTLQ--SISPKNFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 1541 bits (3989), Expect = 0.0
Identities = 798/1223 (65%), Positives = 939/1223 (76%), Gaps = 51/1223 (4%)
Query: 706 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 765
T + +P P + E +TS+ ++W S P+ + Y + Y ++ G +
Sbjct: 314 TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 365
Query: 766 KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 825
K+ D T I GL P + Y + V+A + G G S+ + T P
Sbjct: 366 KE-----------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA 414
Query: 826 K-PRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT 883
PR V T ++QW PV+ G ++GYR+ + + P+ + +D T
Sbjct: 415 SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT 474
Query: 884 --DIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQ 936
+ + +Y R+ A VG G +S P +V T G P NL +E + TS+
Sbjct: 475 VGSLLEDETYTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSIT 529
Query: 937 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 996
LSW PP R I KY LL+R+ + + + P T+ + LKP+T Y ++ A
Sbjct: 530 LSWSPP----RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAA 583
Query: 997 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1056
+ +G G ++P V+ RTL + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+
Sbjct: 584 RSPQGLGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 641
Query: 1057 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG 1116
+ +VDGR T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+
Sbjct: 642 --LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 699
Query: 1117 KTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR 1175
K + DG I V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR
Sbjct: 700 KPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR 759
Query: 1176 -KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1233
+RRS+R+ R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV+
Sbjct: 760 LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL 819
Query: 1234 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK 1293
+ +E +A SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 820 QKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK 878
Query: 1294 ----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERL 1349
R +S+ R + NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERL
Sbjct: 879 PDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 938
Query: 1350 KANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSD 1409
KAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSD
Sbjct: 939 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 998
Query: 1410 YVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW 1469
Y+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYW
Sbjct: 999 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1058
Query: 1470 PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPT 1529
P+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PT
Sbjct: 1059 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1118
Query: 1530 PFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMR 1589
PFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR
Sbjct: 1119 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1178
Query: 1590 AQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFK 1649
+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFK
Sbjct: 1179 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1238
Query: 1650 RLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1709
RLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
Sbjct: 1239 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1298
Query: 1710 QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1769
QQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYF
Sbjct: 1299 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1358
Query: 1770 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1829
VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
Sbjct: 1359 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1418
Query: 1830 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1889
TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT
Sbjct: 1419 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1478
Query: 1890 EDQYQFSYRAALEYLGSFDHYAT 1912
ED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1479 EDEYQFCYQAALEYLGSFDHYAT 1501
Score = 889 bits (2297), Expect = 0.0
Identities = 444/669 (66%), Positives = 531/669 (79%), Gaps = 28/669 (4%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+Q S P++
Sbjct: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVK 612
Query: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
TS+L+SW+ P + N T Y I+Y + L + TTK L+ L+
Sbjct: 613 MIMKTSVLLSWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKP 660
Query: 680 WTEYRITVT 688
T Y +T
Sbjct: 661 HTFYNFVLT 669
Score = 129 bits (325), Expect = 2e-29
Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 45/412 (10%)
Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
+ A S G+ + A+I+ +++ P P T ++TSI ++W + + +
Sbjct: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 351
Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
EY K D P++I TT+Y + L +EY I V+A +G GP S SV
Sbjct: 352 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 404
Query: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
+ RT E P+ PR V+ +++T++ V W PV + +G IRGY+V+Y ME P G
Sbjct: 405 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 461
Query: 763 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 822
+V DD+ + L + +Y++ V A+T+ GDG S P V T
Sbjct: 462 WQKHNV---------DDSLL--TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 510
Query: 823 VPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 881
VPG+P + + T++ + W PP + Y L F D F + +
Sbjct: 511 VPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYV 567
Query: 882 ATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSW 939
D+ Y FRL+AR+ G G +V++ ++ P F + TSV LSW
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSW 623
Query: 940 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 991
+ P + T Y + Y + + + T +T LKP T Y+
Sbjct: 624 EFP---DNYNSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 665
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 602 bits (1552), Expect = e-171
Identities = 312/681 (45%), Positives = 431/681 (63%), Gaps = 13/681 (1%)
Query: 1238 SKMYATSPYSDPVVSMDLDPQPITDEEE--GLIWVVGPVLAVVFIICIVIAILLYKRKRA 1295
S AT+P + P S + D + DE ++ + +L +VFII ++ + K K+A
Sbjct: 125 SSTAATTPETFPP-SGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQA 183
Query: 1296 ESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNL 1355
S S + N + +P + L +PP+P+ +L + I R A+DN
Sbjct: 184 GSHSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNK 239
Query: 1356 KFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN 1414
F +E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA+
Sbjct: 240 LFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAS 299
Query: 1415 YIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT 1474
+I+GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP +G
Sbjct: 300 FINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGC 359
Query: 1475 ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTP 1530
T+G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP P
Sbjct: 360 WTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIG 419
Query: 1531 FLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRA 1590
L FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+ +RA
Sbjct: 420 MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRA 479
Query: 1591 QRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKR 1650
QR MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E EFK+
Sbjct: 480 QRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK 539
Query: 1651 LASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ 1710
L S K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ
Sbjct: 540 LTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ 599
Query: 1711 QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFV 1770
+ +YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y
Sbjct: 600 KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDIT 659
Query: 1771 VDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT 1830
V+ E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K
Sbjct: 660 VELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ 719
Query: 1831 KEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTE 1890
++Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT
Sbjct: 720 QQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTL 778
Query: 1891 DQYQFSYRAALEYLGSFDHYA 1911
+QY+F Y+ EY+ +F YA
Sbjct: 779 EQYEFCYKVVQEYIDAFSDYA 799
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 601 bits (1550), Expect = e-171
Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)
Query: 1238 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1297
S AT+P + P D PI ++ + +L +VFII ++ + K K+A S
Sbjct: 125 SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176
Query: 1298 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1357
S + N + +P + L +PP+P+ +L + I R A+DN F
Sbjct: 177 HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232
Query: 1358 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1416
+E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 233 REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
Query: 1417 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1476
+GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP +G T
Sbjct: 293 NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352
Query: 1477 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1532
+G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP P L
Sbjct: 353 YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412
Query: 1533 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1592
FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+ +RAQR
Sbjct: 413 KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472
Query: 1593 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1652
MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E EFK+L
Sbjct: 473 CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532
Query: 1653 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1712
S K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+
Sbjct: 533 SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592
Query: 1713 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1772
+YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+
Sbjct: 593 SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652
Query: 1773 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1832
E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++
Sbjct: 653 LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712
Query: 1833 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1892
Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 713 QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
Query: 1893 YQFSYRAALEYLGSFDHYA 1911
Y+F Y+ EY+ +F YA
Sbjct: 772 YEFCYKVVQEYIDAFSDYA 790
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 601 bits (1550), Expect = e-171
Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)
Query: 1238 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1297
S AT+P + P D PI ++ + +L +VFII ++ + K K+A S
Sbjct: 125 SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176
Query: 1298 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1357
S + N + +P + L +PP+P+ +L + I R A+DN F
Sbjct: 177 HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232
Query: 1358 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1416
+E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 233 REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
Query: 1417 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1476
+GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP +G T
Sbjct: 293 NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352
Query: 1477 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1532
+G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP P L
Sbjct: 353 YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412
Query: 1533 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1592
FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+ +RAQR
Sbjct: 413 KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472
Query: 1593 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1652
MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E EFK+L
Sbjct: 473 CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532
Query: 1653 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1712
S K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+
Sbjct: 533 SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592
Query: 1713 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1772
+YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+
Sbjct: 593 SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652
Query: 1773 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1832
E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++
Sbjct: 653 LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712
Query: 1833 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1892
Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 713 QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
Query: 1893 YQFSYRAALEYLGSFDHYA 1911
Y+F Y+ EY+ +F YA
Sbjct: 772 YEFCYKVVQEYIDAFSDYA 790
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 556 bits (1433), Expect = e-158
Identities = 294/655 (44%), Positives = 411/655 (62%), Gaps = 15/655 (2%)
Query: 1267 LIWVVGPVLAVVFIICIVIAILLYKRKR-AESDSRKSSIPNNKEIPSHHPTDPVELRRLN 1325
L W++ P+L ++ ++ + ++++R A + +PN I V L L+
Sbjct: 48 LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNG--ILEEQEQQRVML--LS 103
Query: 1326 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKN 1384
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KN
Sbjct: 104 RSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKN 163
Query: 1385 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1444
RY N++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+W
Sbjct: 164 RYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW 223
Query: 1445 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK-- 1502
EQ+SAT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F +
Sbjct: 224 EQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQL 283
Query: 1503 -NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1561
+G R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG
Sbjct: 284 PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTG 343
Query: 1562 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1621
FIVIDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+
Sbjct: 344 TFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELD 403
Query: 1622 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1681
+L ++Q + T + G+E EF++L + + + NLP N K R++ I+PY
Sbjct: 404 VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPY 463
Query: 1682 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1741
+ RV L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +V
Sbjct: 464 DFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIV 523
Query: 1742 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQ 1796
MLT+++E ++KC+QYWP E S + ++ + +R+F VT ++ Q
Sbjct: 524 MLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQ 583
Query: 1797 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1856
R VRQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI
Sbjct: 584 VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIA 642
Query: 1857 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1911
LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 643 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 550 bits (1416), Expect = e-156
Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)
Query: 1330 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 1388
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KNRY N
Sbjct: 50 GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109
Query: 1389 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1448
++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+WEQ+S
Sbjct: 110 ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169
Query: 1449 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1505
AT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F + +G
Sbjct: 170 ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
Query: 1506 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1565
R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG FIV
Sbjct: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289
Query: 1566 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1625
IDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+ +L
Sbjct: 290 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349
Query: 1626 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1685
++Q + T + G+E EF++L + + + NLP N K R++ I+PY+ R
Sbjct: 350 EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409
Query: 1686 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1745
V L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+
Sbjct: 410 VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469
Query: 1746 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1800
++E ++KC+QYWP E S + ++ + +R+F VT ++ Q R V
Sbjct: 470 VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529
Query: 1801 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1860
RQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 530 RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588
Query: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1911
LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 589 LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 509 bits (1312), Expect = e-144
Identities = 302/766 (39%), Positives = 431/766 (56%), Gaps = 67/766 (8%)
Query: 1200 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1254
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
Query: 1255 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1313
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
Query: 1314 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1333
H DP+ + R N +S
Sbjct: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
Query: 1334 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1387
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
Query: 1388 NVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR 1447
N+IAYDHSRV+L +E P SDY+NANYIDGY++ + YIATQG + ET DFWRMIW+++
Sbjct: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
Query: 1448 SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSE 1507
SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L + G +E
Sbjct: 979 SACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1037
Query: 1508 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID 1567
REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTGC+IVID
Sbjct: 1038 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1097
Query: 1568 AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA 1627
ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P A
Sbjct: 1098 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1157
Query: 1628 YIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1685
+ +I++ N + ++ EF+ L S + A LP N KNR ++++P +
Sbjct: 1158 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1217
Query: 1686 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1745
L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T +VML +
Sbjct: 1218 PFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1276
Query: 1746 LREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQ 1802
+ + C QYWP E RY V+ M+ + ++ I R +T ++G V+Q
Sbjct: 1277 VDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQ 1333
Query: 1803 FQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIV 1860
FQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F + IV
Sbjct: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393
Query: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
Score = 69.7 bits (169), Expect = 3e-11
Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)
Query: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
Query: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
Query: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
Query: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 623
+ T + L P + Y F + A + +G G +TA I+ T S P+ P + S +
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608
Query: 624 TSILVSWQPPPVEKQNGIITEYSI 647
T+ ++ P + + I+ Y I
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQI 632
Score = 62.4 bits (150), Expect = 4e-09
Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 44/385 (11%)
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 627
S+RLQ + +R +S +G G S A++ R +P APPQ + T +L
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309
Query: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
+ + II + ++Y G + H + + Y L L+ TEY R+
Sbjct: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363
Query: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
+T + G G ++ RT P P+ +++ + + + V W S N
Sbjct: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423
Query: 746 GYQV--HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 803
+ HY R N E K + D +H +++ L P T+ SL +
Sbjct: 424 NVTICYHYFRGHN-ESKADCLDMD----------PKAPQH--VVNHLPPYTNVSLKMILT 470
Query: 804 TTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFG 861
+G S+ ++ T VPG P + T N + W P+D G + Y + +
Sbjct: 471 NPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYS 529
Query: 862 R-KDMEPLT-------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 913
+ +P T+ H +H G +Y F + A GFG ++
Sbjct: 530 SIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTT 589
Query: 914 PEEVPT-----GFPQNLHSEGTTST 933
PT G +L+ TT T
Sbjct: 590 NISAPTLPDYEGVDASLNETATTIT 614
Score = 60.5 bits (145), Expect = 2e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
Query: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
PPR PP + P +N + P + V++ + + T + +
Sbjct: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
Query: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
+L + Y + T L I + + P T + E A
Sbjct: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
Query: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
Query: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
Query: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
Query: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
Score = 45.8 bits (107), Expect = 4e-04
Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)
Query: 790 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 845
L P+T Y + V T G G P + T A P + L I Q + W
Sbjct: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412
Query: 846 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 899
TF Y G + + L+ K + + ++ N
Sbjct: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471
Query: 900 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 959
G E I E+VP P + + L+W+ P+ + NGIIT+Y + Y
Sbjct: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529
Query: 960 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 1004
I P +P+ P T L L P TTY +RA T KG GP
Sbjct: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 503 bits (1295), Expect = e-142
Identities = 302/772 (39%), Positives = 431/772 (55%), Gaps = 73/772 (9%)
Query: 1200 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1254
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
Query: 1255 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1313
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
Query: 1314 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1333
H DP+ + R N +S
Sbjct: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
Query: 1334 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1387
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
Query: 1388 NVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFGDFWR 1441
N+IAYDHSRV+L +E P SDY+NANYID GY++ + YIATQG + ET DFWR
Sbjct: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978
Query: 1442 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1501
MIW+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L
Sbjct: 979 MIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037
Query: 1502 KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1561
+ G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTG
Sbjct: 1038 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG 1097
Query: 1562 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1621
C+IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P
Sbjct: 1098 CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP 1157
Query: 1622 ARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIM 1679
A + +I++ N + ++ EF+ L S + A LP N KNR ++++
Sbjct: 1158 VCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1217
Query: 1680 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1739
P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T
Sbjct: 1218 PPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1276
Query: 1740 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQ 1796
+VML ++ + C QYWP E RY V+ M+ + ++ I R +T ++G
Sbjct: 1277 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY 1334
Query: 1797 SRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVF 1854
V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F
Sbjct: 1335 -LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMF 1393
Query: 1855 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
+ IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1394 CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
Score = 69.7 bits (169), Expect = 3e-11
Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)
Query: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
Query: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
Query: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
Query: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 623
+ T + L P + Y F + A + +G G +TA I+ T S P+ P + S +
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608
Query: 624 TSILVSWQPPPVEKQNGIITEYSI 647
T+ ++ P + + I+ Y I
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQI 632
Score = 62.4 bits (150), Expect = 4e-09
Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 44/385 (11%)
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 627
S+RLQ + +R +S +G G S A++ R +P APPQ + T +L
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309
Query: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
+ + II + ++Y G + H + + Y L L+ TEY R+
Sbjct: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363
Query: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
+T + G G ++ RT P P+ +++ + + + V W S N
Sbjct: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423
Query: 746 GYQV--HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 803
+ HY R N E K + D +H +++ L P T+ SL +
Sbjct: 424 NVTICYHYFRGHN-ESKADCLDMD----------PKAPQH--VVNHLPPYTNVSLKMILT 470
Query: 804 TTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFG 861
+G S+ ++ T VPG P + T N + W P+D G + Y + +
Sbjct: 471 NPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYS 529
Query: 862 R-KDMEPLT-------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 913
+ +P T+ H +H G +Y F + A GFG ++
Sbjct: 530 SIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTT 589
Query: 914 PEEVPT-----GFPQNLHSEGTTST 933
PT G +L+ TT T
Sbjct: 590 NISAPTLPDYEGVDASLNETATTIT 614
Score = 60.5 bits (145), Expect = 2e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
Query: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
PPR PP + P +N + P + V++ + + T + +
Sbjct: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
Query: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
+L + Y + T L I + + P T + E A
Sbjct: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
Query: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
Query: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
Query: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
Query: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
Score = 45.8 bits (107), Expect = 4e-04
Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)
Query: 790 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 845
L P+T Y + V T G G P + T A P + L I Q + W
Sbjct: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412
Query: 846 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 899
TF Y G + + L+ K + + ++ N
Sbjct: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471
Query: 900 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 959
G E I E+VP P + + L+W+ P+ + NGIIT+Y + Y
Sbjct: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529
Query: 960 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 1004
I P +P+ P T L L P TTY +RA T KG GP
Sbjct: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 1334 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1393
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 877 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 936
Query: 1394 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1453
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 937 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 996
Query: 1454 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1513
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 997 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1055
Query: 1514 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1573
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1056 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1115
Query: 1574 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1633
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1116 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1175
Query: 1634 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1691
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1176 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1235
Query: 1692 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1751
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1236 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1292
Query: 1752 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1808
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1293 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1351
Query: 1809 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1866
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1352 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1411
Query: 1867 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1380 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1439
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
Query: 1440 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1499
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
Query: 1500 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1553
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
Query: 1554 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1613
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
Query: 1614 TCG 1616
G
Sbjct: 1450 NSG 1452
Score = 69.3 bits (168), Expect = 3e-11
Identities = 77/349 (22%), Positives = 127/349 (36%), Gaps = 31/349 (8%)
Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
+R R+ G+G S P APPQ S +T + + + I+
Sbjct: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314
Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 700
TA +D+ P D+T Y + L+ TEY I+V T + G G
Sbjct: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368
Query: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760
++ RT P PRK+EV V S + + W N VHY G+ +
Sbjct: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ 428
Query: 761 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 820
+ + W+ +++ I + L P T+ S+ + +G S+ +V T
Sbjct: 429 --------VREEVSWDTENSHPQHTI-TNLSPYTNVSVKLILMNPEGR-KESQELIVQTD 478
Query: 821 GAVPGK--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE-- 875
+PG + T +QW P T+G + Y + + +P L
Sbjct: 479 EDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGR 538
Query: 876 -----KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919
E HF ++ G +Y F + A GFG + + P+
Sbjct: 539 VSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
Score = 67.4 bits (163), Expect = 1e-10
Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)
Query: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
Query: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
Query: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
E I L W P I YE+ YK + G ++ E T
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
Query: 570 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
+ GL P + Y F + A + +G G A T S PS P ++ T + T V+
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605
Query: 630 WQPPPVEKQNGIITEYSI 647
P + ++ Y I
Sbjct: 606 VMLKPAHSRGAPVSVYQI 623
Score = 66.6 bits (161), Expect = 2e-10
Identities = 93/436 (21%), Positives = 165/436 (37%), Gaps = 61/436 (13%)
Query: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
Query: 250 GGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL- 308
S+N V + Y + D P+ ++ + Y + T
Sbjct: 304 ANSINGDGPIVAREVEYC-----TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRP 358
Query: 309 ------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPK 361
A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 359 GEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTRCHSY 413
Query: 362 N-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 407
N E++ +E+ ++++ LSPY++ +++ +N GR S+
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQE 472
Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 463
++ QT E P + P + I +QW+EP + G I Y + Y + DP +
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDL 532
Query: 464 NNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
+N +++ +GN L P TYS + A T+ G GP +++ Q T+
Sbjct: 533 SN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTTKISA 585
Query: 516 PGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT----IEPG 567
P P P ++T +++L R ++ Y++V ++ ++ T P
Sbjct: 586 PSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPV 645
Query: 568 TSYRLQGLKPNSLYYF 583
+ NS YYF
Sbjct: 646 PIHFQNASLLNSQYYF 661
Score = 58.5 bits (140), Expect = 6e-08
Identities = 78/351 (22%), Positives = 129/351 (36%), Gaps = 45/351 (12%)
Query: 682 EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 741
+YR + T+ G G + + L+ VP PP ++ +V +T + + + N
Sbjct: 257 KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310
Query: 742 GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVT 801
G I +V Y QP+ D+T + I L P+T Y ++V
Sbjct: 311 GPIVAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVL 354
Query: 802 AYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 856
T G+G P T + G +L + + I+W P Y
Sbjct: 355 L-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSY 413
Query: 857 RLKF-------GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 909
L G++ + + + T T++ + +L N G E
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQEL 473
Query: 910 EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIP 964
+ E++P P T + L W+ P + G+IT Y + Y+ D I
Sbjct: 474 IVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEID 531
Query: 965 LLPMEQLI--VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013
L + + +T GL P TTY +RA T+KG GP + + QF T
Sbjct: 532 LSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
Score = 51.6 bits (122), Expect = 7e-06
Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)
Query: 980 TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1032
T+T L P T VK+ +G S + +T +P + + F K
Sbjct: 445 TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498
Query: 1033 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1079
+ L W P + Y ++I Y + E+D G T L L P
Sbjct: 499 -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
Query: 1080 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1132
+YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 558 TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613
Query: 1133 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1188
+ Y I++ + R K +K + P + LL
Sbjct: 614 RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657
Query: 1189 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1243
+ Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 658 QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717
Query: 1244 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1303
+ + P+P + + + + G + ++ + I + ++L +KR + RK +
Sbjct: 718 QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776
Query: 1304 IPNNKE 1309
+ + ++
Sbjct: 777 MSSTRQ 782
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 1334 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1393
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 890 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949
Query: 1394 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1453
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 950 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009
Query: 1454 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1513
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068
Query: 1514 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1573
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128
Query: 1574 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1633
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188
Query: 1634 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1691
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248
Query: 1692 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1751
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305
Query: 1752 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1808
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364
Query: 1809 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1866
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424
Query: 1867 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1380 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1439
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
Query: 1440 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1499
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
Query: 1500 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1553
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
Query: 1554 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1613
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
Query: 1614 TCG 1616
G
Sbjct: 1463 NSG 1465
Score = 69.3 bits (168), Expect = 3e-11
Identities = 77/349 (22%), Positives = 127/349 (36%), Gaps = 31/349 (8%)
Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
+R R+ G+G S P APPQ S +T + + + I+
Sbjct: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314
Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 700
TA +D+ P D+T Y + L+ TEY I+V T + G G
Sbjct: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368
Query: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760
++ RT P PRK+EV V S + + W N VHY G+ +
Sbjct: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ 428
Query: 761 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 820
+ + W+ +++ I + L P T+ S+ + +G S+ +V T
Sbjct: 429 --------VREEVSWDTENSHPQHTI-TNLSPYTNVSVKLILMNPEGR-KESQELIVQTD 478
Query: 821 GAVPGK--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE-- 875
+PG + T +QW P T+G + Y + + +P L
Sbjct: 479 EDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGR 538
Query: 876 -----KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919
E HF ++ G +Y F + A GFG + + P+
Sbjct: 539 VSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
Score = 67.4 bits (163), Expect = 1e-10
Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)
Query: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
Query: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
Query: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
E I L W P I YE+ YK + G ++ E T
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
Query: 570 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
+ GL P + Y F + A + +G G A T S PS P ++ T + T V+
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605
Query: 630 WQPPPVEKQNGIITEYSI 647
P + ++ Y I
Sbjct: 606 VMLKPAHSRGAPVSVYQI 623
Score = 66.6 bits (161), Expect = 2e-10
Identities = 93/436 (21%), Positives = 165/436 (37%), Gaps = 61/436 (13%)
Query: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
Query: 250 GGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL- 308
S+N V + Y + D P+ ++ + Y + T
Sbjct: 304 ANSINGDGPIVAREVEYC-----TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRP 358
Query: 309 ------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPK 361
A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 359 GEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTRCHSY 413
Query: 362 N-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 407
N E++ +E+ ++++ LSPY++ +++ +N GR S+
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQE 472
Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 463
++ QT E P + P + I +QW+EP + G I Y + Y + DP +
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDL 532
Query: 464 NNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
+N +++ +GN L P TYS + A T+ G GP +++ Q T+
Sbjct: 533 SN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTTKISA 585
Query: 516 PGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT----IEPG 567
P P P ++T +++L R ++ Y++V ++ ++ T P
Sbjct: 586 PSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPV 645
Query: 568 TSYRLQGLKPNSLYYF 583
+ NS YYF
Sbjct: 646 PIHFQNASLLNSQYYF 661
Score = 58.5 bits (140), Expect = 6e-08
Identities = 78/351 (22%), Positives = 129/351 (36%), Gaps = 45/351 (12%)
Query: 682 EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 741
+YR + T+ G G + + L+ VP PP ++ +V +T + + + N
Sbjct: 257 KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310
Query: 742 GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVT 801
G I +V Y QP+ D+T + I L P+T Y ++V
Sbjct: 311 GPIVAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVL 354
Query: 802 AYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 856
T G+G P T + G +L + + I+W P Y
Sbjct: 355 L-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSY 413
Query: 857 RLKF-------GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 909
L G++ + + + T T++ + +L N G E
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQEL 473
Query: 910 EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIP 964
+ E++P P T + L W+ P + G+IT Y + Y+ D I
Sbjct: 474 IVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEID 531
Query: 965 LLPMEQLI--VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013
L + + +T GL P TTY +RA T+KG GP + + QF T
Sbjct: 532 LSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
Score = 51.6 bits (122), Expect = 7e-06
Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)
Query: 980 TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1032
T+T L P T VK+ +G S + +T +P + + F K
Sbjct: 445 TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498
Query: 1033 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1079
+ L W P + Y ++I Y + E+D G T L L P
Sbjct: 499 -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
Query: 1080 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1132
+YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 558 TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613
Query: 1133 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1188
+ Y I++ + R K +K + P + LL
Sbjct: 614 RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657
Query: 1189 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1243
+ Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 658 QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717
Query: 1244 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1303
+ + P+P + + + + G + ++ + I + ++L +KR + RK +
Sbjct: 718 QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776
Query: 1304 IPNNKE 1309
+ + ++
Sbjct: 777 MSSTRQ 782
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 495 bits (1275), Expect = e-139
Identities = 354/1096 (32%), Positives = 535/1096 (48%), Gaps = 146/1096 (13%)
Query: 918 PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 977
P PQN+ + + L W+P A T+ Y+ + + ++ +
Sbjct: 386 PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445
Query: 978 TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1030
TL GL+P T +++ +G S + +T +P++ + F K
Sbjct: 446 HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501
Query: 1031 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1074
+ + W+ P N + ++I Y K V +D A T L V
Sbjct: 502 ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555
Query: 1075 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1130
L P +YSF + + ++A G VT + A + + P + T L D ITV L
Sbjct: 556 LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613
Query: 1131 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1181
+ Y ++V L+KSR F P + LD L
Sbjct: 614 AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661
Query: 1182 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1240
+ ELKP A+ V FT+GD+K Y G+ N L + Y ++F + E+K+
Sbjct: 662 HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717
Query: 1241 YAT---SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKR--- 1294
+ + S ++P+ D + V+ +L +FII ++ +L KR+R
Sbjct: 718 NCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--MFIIILLGVMLTIKRRRNAY 775
Query: 1295 ----------------------------AESDSRKSSIPNNKE----------------- 1309
A+ + K S N E
Sbjct: 776 SYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSR 835
Query: 1310 ---------IPSH--HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1358
I +H DPVE+ P P I + +L HI ++K F
Sbjct: 836 GELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
Query: 1359 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1418
+EYE++ GQ +W+ + + N+ KNRY N+I+YDHSRV L ++G P SDY+NANYIDG
Sbjct: 891 EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950
Query: 1419 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1478
Y + YIATQG + ET DFWRMIW++ SA++VM+T L E RVKC +YWP TE +G
Sbjct: 951 YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYG 1009
Query: 1479 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1538
++VTL++T LA Y +RTF + K G E RE+R F FT+WPDHGVP + T L F+R+V
Sbjct: 1010 DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV 1069
Query: 1539 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1598
K NPP+AGP+VVHCSAG GRTGCFI ID ML+ ++E VDI+ V +RAQR +VQT
Sbjct: 1070 KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1129
Query: 1599 EDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSK 1655
E+QY+F+HDA+LEA CGNT +P R+LY I +L +T + E + + + +
Sbjct: 1130 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPR 1188
Query: 1656 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI 1715
LP N KNR ++++P + L + G E S+YINA+ +D ++Q A++
Sbjct: 1189 VRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFV 1247
Query: 1716 ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA 1775
TQ PL T DFWR+++++N + VVML ++ + C QYWP + S Y V+ ++
Sbjct: 1248 VTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVS 1305
Query: 1776 EYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKE 1832
I R F++ + Q R V+ Q+ WP + P S + + ++ K +E
Sbjct: 1306 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1365
Query: 1833 QF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1891
Q+ G++G VHC G GR+G F + V E ++ + ++D+F VK LR + MV+T +
Sbjct: 1366 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1425
Query: 1892 QYQFSYRAALEYLGSF 1907
QY+F Y ALEYL SF
Sbjct: 1426 QYKFVYEVALEYLSSF 1441
Score = 75.1 bits (183), Expect = 6e-13
Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)
Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351
R + Y CV S G + A++ VK P P P E A T W N +
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
Query: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407
+ + + + + + E V + Y + L P +YE RV+ G GPP P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466
+ T+T P P++V+ + + + +QW EP G + Y Q+V N
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
Query: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520
++ + S T+ L P T +++L S +G + S+ V+ T+ VPG PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
Query: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573
E I + W PP + I YE+ YK G ++ + G ++L+
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
Query: 574 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
GL P + Y F + A + +G G A T S PS P D T + T ++
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608
Query: 630 WQPPPVEKQNGIITEYSI 647
P + + ++ Y +
Sbjct: 609 VMLKPAQSRGAPVSVYQL 626
Score = 73.2 bits (178), Expect = 2e-12
Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)
Query: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
SVA + S ++R V ++ G G + L P + P L + W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
Query: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496
+P + G + ++ W + ++ DS + +L P Y ++VL
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
Query: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547
G GP + T+ P P N + + L W P + Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
Query: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
+ V+ ++ E+ I+ + Y L+GL+P RL +P+G S E+ +T +
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483
Query: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 661
P A P + P I + W+PP + NG+IT Y I Y AV D + +
Sbjct: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541
Query: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714
+ + ++ T +L L T Y T+ A T G GP ++ I T PS P
Sbjct: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592
Score = 61.2 bits (147), Expect = 9e-09
Identities = 82/346 (23%), Positives = 126/346 (36%), Gaps = 54/346 (15%)
Query: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740
++YR + +D G G + + LI P PP E+ AV +T + W P N
Sbjct: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314
Query: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYS 797
G G +LK+V + +T D + L P+ Y
Sbjct: 315 IGD-----------------GPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
Query: 798 LTVTAYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------P 846
+ V T G+G P TT V G + I + +QW P
Sbjct: 358 IRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
Query: 847 VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 906
++ Y+ F ++ E ++ S H+T + + RL N G E
Sbjct: 417 CHSYNLTVQYQYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMES 473
Query: 907 MVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL 966
+ E+VP P G + + W+PP E NG+IT Y + Y+ + L
Sbjct: 474 EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLD 530
Query: 967 PMEQLI--------VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 1004
P L + +T GL P TTY ++A T+KG GP
Sbjct: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576
Score = 53.1 bits (126), Expect = 2e-06
Identities = 91/409 (22%), Positives = 154/409 (37%), Gaps = 66/409 (16%)
Query: 579 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 631
S+ +R RS G G S AE+ + + P APP+ ++ + P++ SI+
Sbjct: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315
Query: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 689
+G I ++Y G + H + D+ Y L L+ EY R+ +T
Sbjct: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364
Query: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749
+ G GP + RT P P+ VE+ + + + + W GY V
Sbjct: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP----------FGYAV 414
Query: 750 HYVRMENGEPKGQPMLKDVMLADAQWEFDDT--TEHDMIISGLQPETSYSLTVTAYTTKG 807
N + Q + Q+E ++ T + GL+P + L + +G
Sbjct: 415 TRCHSYNLTVQYQYVFNQ-----QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEG 469
Query: 808 DGARSKPKLVSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-D 864
S+ +V T VPG L + IQW PP +T G + Y + +
Sbjct: 470 R-MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGS 528
Query: 865 MEPLTTLEFSE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISI 913
++P L E H ++ G +Y F + A GFG + +IS
Sbjct: 529 LDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA 588
Query: 914 PE--EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960
P E T P N T T++ + +P R ++ Y L+ ++
Sbjct: 589 PSMPEYDTDTPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 490 bits (1261), Expect = e-138
Identities = 356/1115 (31%), Positives = 536/1115 (48%), Gaps = 165/1115 (14%)
Query: 918 PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 977
P PQN+ + + L W+P A T+ Y+ + + ++ +
Sbjct: 386 PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445
Query: 978 TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1030
TL GL+P T +++ +G S + +T +P++ + F K
Sbjct: 446 HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501
Query: 1031 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1074
+ + W+ P N + ++I Y K V +D A T L V
Sbjct: 502 ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555
Query: 1075 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1130
L P +YSF + + ++A G VT + A + + P + T L D ITV L
Sbjct: 556 LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613
Query: 1131 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1181
+ Y ++V L+KSR F P + LD L
Sbjct: 614 AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661
Query: 1182 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1240
+ ELKP A+ V FT+GD+K Y G+ N L + Y ++F + E+K+
Sbjct: 662 HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717
Query: 1241 YAT-----SPYSDPVV-----------------SMDLDPQPITDEEEGLIWVVGPVLAVV 1278
+P V S ++P+ D + V+ +L +
Sbjct: 718 NCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--M 775
Query: 1279 FIICIVIAILLYKRKR-------------------------------AESDSRKSSIPNN 1307
FII ++ +L KR+R A+ + K S N
Sbjct: 776 FIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRN 835
Query: 1308 KE--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIPI 1339
E I +H DPVE+ P P I +
Sbjct: 836 DEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRV 890
Query: 1340 LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLL 1399
+L HI ++K F +EYE++ GQ +W+ + + N+ KNRY N+I+YDHSRV L
Sbjct: 891 ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
Query: 1400 SAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEE 1459
++G P SDY+NANYIDGY + YIATQG + ET DFWRMIW++ SA++VM+T L E
Sbjct: 951 LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010
Query: 1460 RSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAW 1519
RVKC +YWP TE +G ++VTL++T LA Y +RTF + K G E RE+R F FT+W
Sbjct: 1011 VGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1069
Query: 1520 PDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTV 1579
PDHGVP + T L F+R+VK NPP+AGP+VVHCSAG GRTGCFI ID ML+ ++E V
Sbjct: 1070 PDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVV 1129
Query: 1580 DIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIE 1636
DI+ V +RAQR +VQTE+QY+F+HDA+LEA CGNT +P R+LY I +L +
Sbjct: 1130 DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-Q 1188
Query: 1637 TGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1696
T + E + + + + LP N KNR ++++P + L + G E
Sbjct: 1189 TNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ES 1247
Query: 1697 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ 1756
S+YINA+ +D ++Q A++ TQ PL T DFWR+++++N + VVML ++ + C Q
Sbjct: 1248 SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQ 1305
Query: 1757 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGV 1813
YWP + S Y V+ ++ I R F++ + Q R V+ Q+ WP +
Sbjct: 1306 YWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDT 1365
Query: 1814 PKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1872
P S + + ++ K +EQ+ G++G VHC G GR+G F + V E ++ + ++D+
Sbjct: 1366 PPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDV 1425
Query: 1873 FQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1907
F VK LR + MV+T +QY+F Y ALEYL SF
Sbjct: 1426 FHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
Score = 75.1 bits (183), Expect = 6e-13
Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)
Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351
R + Y CV S G + A++ VK P P P E A T W N +
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
Query: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407
+ + + + + + E V + Y + L P +YE RV+ G GPP P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466
+ T+T P P++V+ + + + +QW EP G + Y Q+V N
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
Query: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520
++ + S T+ L P T +++L S +G + S+ V+ T+ VPG PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
Query: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573
E I + W PP + I YE+ YK G ++ + G ++L+
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
Query: 574 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
GL P + Y F + A + +G G A T S PS P D T + T ++
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608
Query: 630 WQPPPVEKQNGIITEYSI 647
P + + ++ Y +
Sbjct: 609 VMLKPAQSRGAPVSVYQL 626
Score = 73.2 bits (178), Expect = 2e-12
Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)
Query: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
SVA + S ++R V ++ G G + L P + P L + W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
Query: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496
+P + G + ++ W + ++ DS + +L P Y ++VL
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
Query: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547
G GP + T+ P P N + + L W P + Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
Query: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
+ V+ ++ E+ I+ + Y L+GL+P RL +P+G S E+ +T +
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483
Query: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 661
P A P + P I + W+PP + NG+IT Y I Y AV D + +
Sbjct: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541
Query: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714
+ + ++ T +L L T Y T+ A T G GP ++ I T PS P
Sbjct: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592
Score = 61.2 bits (147), Expect = 9e-09
Identities = 82/346 (23%), Positives = 126/346 (36%), Gaps = 54/346 (15%)
Query: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740
++YR + +D G G + + LI P PP E+ AV +T + W P N
Sbjct: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314
Query: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYS 797
G G +LK+V + +T D + L P+ Y
Sbjct: 315 IGD-----------------GPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
Query: 798 LTVTAYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------P 846
+ V T G+G P TT V G + I + +QW P
Sbjct: 358 IRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
Query: 847 VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 906
++ Y+ F ++ E ++ S H+T + + RL N G E
Sbjct: 417 CHSYNLTVQYQYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMES 473
Query: 907 MVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL 966
+ E+VP P G + + W+PP E NG+IT Y + Y+ + L
Sbjct: 474 EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLD 530
Query: 967 PMEQLI--------VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 1004
P L + +T GL P TTY ++A T+KG GP
Sbjct: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576
Score = 53.1 bits (126), Expect = 2e-06
Identities = 91/409 (22%), Positives = 154/409 (37%), Gaps = 66/409 (16%)
Query: 579 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 631
S+ +R RS G G S AE+ + + P APP+ ++ + P++ SI+
Sbjct: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315
Query: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 689
+G I ++Y G + H + D+ Y L L+ EY R+ +T
Sbjct: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364
Query: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749
+ G GP + RT P P+ VE+ + + + + W GY V
Sbjct: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP----------FGYAV 414
Query: 750 HYVRMENGEPKGQPMLKDVMLADAQWEFDDT--TEHDMIISGLQPETSYSLTVTAYTTKG 807
N + Q + Q+E ++ T + GL+P + L + +G
Sbjct: 415 TRCHSYNLTVQYQYVFNQ-----QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEG 469
Query: 808 DGARSKPKLVSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-D 864
S+ +V T VPG L + IQW PP +T G + Y + +
Sbjct: 470 R-MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGS 528
Query: 865 MEPLTTLEFSE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISI 913
++P L E H ++ G +Y F + A GFG + +IS
Sbjct: 529 LDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA 588
Query: 914 PE--EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960
P E T P N T T++ + +P R ++ Y L+ ++
Sbjct: 589 PSMPEYDTDTPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 459 bits (1182), Expect = e-129
Identities = 264/678 (38%), Positives = 373/678 (55%), Gaps = 52/678 (7%)
Query: 1274 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQT---- 1328
V++ + +C+++ I + R + + P +E+PS R+ FQT
Sbjct: 743 VVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKC-FQTAHFY 801
Query: 1329 ------PGMASHPPIPILELAD------------HIERLKANDNLKFSQEYESID---PG 1367
P + + IPI+ + D HI L +N+ FS+++E +
Sbjct: 802 VEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAD 861
Query: 1368 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1425
T EHSN NK KNRY N++AYDHSRV L + G SDY+NANY+DGY K AY
Sbjct: 862 MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAY 921
Query: 1426 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1485
IATQG L TF DFWRMIWEQ + +VM+T L E+ R KCDQYWP+ +E +G + VTL
Sbjct: 922 IATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK 981
Query: 1486 DTVELATYCVRTFALYKN-----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF 1534
T A Y VR F++ G +R V Q+ +T WPD GVPE+ P L F
Sbjct: 982 STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1041
Query: 1535 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1594
+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV++ G + +R QRNY
Sbjct: 1042 VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY 1101
Query: 1595 MVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASS 1654
+VQTE+QYIFIHDALLEA+ TEV + L++Y+ + G T +E +FK +
Sbjct: 1102 LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQC 1160
Query: 1655 KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY 1714
A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I GY + +
Sbjct: 1161 NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEF 1220
Query: 1715 IATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-- 1771
I TQ PL TT+DFWRM+W+HN+ I+VML + + ++ YWP+ E S + F V
Sbjct: 1221 IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTL 1279
Query: 1772 ---DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH 1828
D + N Q I+ +F + +D VR FQ WP P S + I +
Sbjct: 1280 ISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI- 1336
Query: 1829 KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1888
+E +DGP VH G G+ L+ + +++ E VD+FQ KM+ RP +
Sbjct: 1337 -KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFT 1395
Query: 1889 TEDQYQFSYRAALEYLGS 1906
+QYQF Y+A L + +
Sbjct: 1396 DIEQYQFIYKAMLSLVST 1413
Score = 36.2 bits (82), Expect = 0.32
Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Query: 710 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 767
V S PP ++V+ +N T+++VSW P H I Y + Y +N + K + KD
Sbjct: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEKEKTFTKD 401
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 454 bits (1169), Expect = e-127
Identities = 313/954 (32%), Positives = 463/954 (48%), Gaps = 101/954 (10%)
Query: 1030 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1076
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 1077 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1131
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 1132 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1190
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 1191 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1249
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 1250 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1293
P ++ EE GLI + LAV+ ++ I +++ K K
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
Query: 1294 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1318
D R + + P P
Sbjct: 788 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
Query: 1319 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1378
+ + T + HP + + +L HI ++K + F QEYES G W+ + +
Sbjct: 848 CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
Query: 1379 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1438
+R + AYD RV L + G P +DY+NANYIDGY + N +IATQG PE D
Sbjct: 902 DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYD 961
Query: 1439 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTF 1498
FWRM+W++ +++VM+TKL E RVKC +YWP ++T+G +++ L+ T LA Y VRTF
Sbjct: 962 FWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTF 1020
Query: 1499 ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1558
AL + G S + EVRQF FTAWP+HGVP H T LAF+RRVK PPDAGP+V+HCSAG G
Sbjct: 1021 ALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1080
Query: 1559 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1618
RTGC+IV+D ML+ + E VDIY V + ++R M+QTE+QYIFIHDA+LEA CG T
Sbjct: 1081 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1140
Query: 1619 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLV 1676
+P A +++ +I+ N + + EF+ L S A LP N+ KNR +
Sbjct: 1141 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1200
Query: 1677 NIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE 1734
+++P + CL + +G ++YINA+ D Y + A+I T PL TT DFWR++++
Sbjct: 1201 DVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD 1257
Query: 1735 HNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1793
+ T +VML +L + C QYWP +Y V+ M+ + R F+V +
Sbjct: 1258 YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNIS 1317
Query: 1794 DGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1850
Q VR FQF W + P S + F+ + +V K + + G DG VHC G GR
Sbjct: 1318 RLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGR 1376
Query: 1851 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1904
+G F + VLE +R +VD+F K LR +P MV+T DQY F Y ALEYL
Sbjct: 1377 SGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430
Score = 63.9 bits (154), Expect = 1e-09
Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)
Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626
+ L P + Y F + AR+ +G G A+ EI+ T S PS D+ S S +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
Query: 627 LVSWQP 632
V +P
Sbjct: 609 TVLLRP 614
Score = 62.4 bits (150), Expect = 4e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
Score = 59.7 bits (143), Expect = 3e-08
Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)
Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
+ E G S Y ++ L P + RL +P+G E++ +T + PS + +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
Query: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675
P I + W+ P ++ NG+IT+Y I Y +++ D P + + T ++
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
Query: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712
L T Y +V A T G G +L+ I TN PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
Score = 54.7 bits (130), Expect = 9e-07
Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)
Query: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
+Y+L L P++ Y + P G G + +RT ++P P+ ++ + +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
Query: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684
+ W+P V + + YT + E + ++Y ++ L +
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
Query: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740
+ + G E V +T+EDVPSG + E++ T ++ + W P +
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
Query: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 800
+G I Y++ Y +E+ +P ++ + E T H + S L P T+Y +V
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567
Query: 801 TAYTTKGDGARSKPKLVSTTGA 822
A T KG G + ++ + A
Sbjct: 568 RARTGKGFGQAALTEITTNISA 589
Score = 52.0 bits (123), Expect = 6e-06
Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)
Query: 790 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 844
L P+T Y ++V T GDG R P L+S T L Q +QW
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
Query: 845 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 897
P T+ Y G + + +E+ +T ++ + RL
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
Query: 898 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 957
N G E E+VP+G + + L W+ P E NG+IT+Y +
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
Query: 958 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 1003
Y+ I N+P + +T + L P TTY VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
Score = 43.9 bits (102), Expect = 0.002
Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)
Query: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
+R +++P+G G S AE+ + + P APPQ + T +++ + +G
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
Query: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699
I I+Y G + H + Y L L+ TEY I+V T D G G
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
Query: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757
++ RT P P+ + + + + + W N + H HY G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
Query: 758 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 817
Q + + V + I L P + + + +G +
Sbjct: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
Query: 818 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 868
+ G + T + + ++W P + G + Y + + + P
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
Query: 869 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919
T+ E + +++H G +Y+F + AR GFG+ + EI+ P+
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 449 bits (1156), Expect = e-126
Identities = 249/615 (40%), Positives = 351/615 (57%), Gaps = 19/615 (3%)
Query: 1298 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1357
D R + + P P + + T + HP + + +L HI ++K + F
Sbjct: 837 DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGF 894
Query: 1358 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1417
QEYES G W+ + + +R + AYD RV L + G P +DY+NANYID
Sbjct: 895 KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950
Query: 1418 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1477
GY + N +IATQG PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+
Sbjct: 951 GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTY 1009
Query: 1478 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR 1537
G +++ L+ T LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RR
Sbjct: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069
Query: 1538 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1597
VK PPDAGP+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+Q
Sbjct: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129
Query: 1598 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SK 1655
TE+QYIFIHDA+LEA CG T +P A +++ +I+ N + + EF+ L S
Sbjct: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189
Query: 1656 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKA 1713
A LP N+ KNR ++++P + CL + +G ++YINA+ D Y + A
Sbjct: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAA 1246
Query: 1714 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVD 1772
+I T PL TT DFWR+++++ T +VML +L + C QYWP +Y V+
Sbjct: 1247 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1306
Query: 1773 PMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHK 1829
M+ + R F+V + Q VR FQF W + P S + F+ + +V K
Sbjct: 1307 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1366
Query: 1830 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1889
+ + G DG VHC G GR+G F + VLE +R +VD+F K LR +P MV+T
Sbjct: 1367 WQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET 1425
Query: 1890 EDQYQFSYRAALEYL 1904
DQY F Y ALEYL
Sbjct: 1426 MDQYHFCYDVALEYL 1440
Score = 63.9 bits (154), Expect = 1e-09
Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)
Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626
+ L P + Y F + AR+ +G G A+ EI+ T S PS D+ S S +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
Query: 627 LVSWQP 632
V +P
Sbjct: 609 TVLLRP 614
Score = 62.4 bits (150), Expect = 4e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
Score = 59.7 bits (143), Expect = 3e-08
Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)
Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
+ E G S Y ++ L P + RL +P+G E++ +T + PS + +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
Query: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675
P I + W+ P ++ NG+IT+Y I Y +++ D P + + T ++
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
Query: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712
L T Y +V A T G G +L+ I TN PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
Score = 54.7 bits (130), Expect = 9e-07
Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)
Query: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
+Y+L L P++ Y + P G G + +RT ++P P+ ++ + +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
Query: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684
+ W+P V + + YT + E + ++Y ++ L +
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
Query: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740
+ + G E V +T+EDVPSG + E++ T ++ + W P +
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
Query: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 800
+G I Y++ Y +E+ +P ++ + E T H + S L P T+Y +V
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567
Query: 801 TAYTTKGDGARSKPKLVSTTGA 822
A T KG G + ++ + A
Sbjct: 568 RARTGKGFGQAALTEITTNISA 589
Score = 52.0 bits (123), Expect = 6e-06
Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)
Query: 790 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 844
L P+T Y ++V T GDG R P L+S T L Q +QW
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
Query: 845 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 897
P T+ Y G + + +E+ +T ++ + RL
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
Query: 898 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 957
N G E E+VP+G + + L W+ P E NG+IT+Y +
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
Query: 958 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 1003
Y+ I N+P + +T + L P TTY VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
Score = 43.9 bits (102), Expect = 0.002
Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)
Query: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
+R +++P+G G S AE+ + + P APPQ + T +++ + +G
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
Query: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699
I I+Y G + H + Y L L+ TEY I+V T D G G
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
Query: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757
++ RT P P+ + + + + + W N + H HY G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
Query: 758 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 817
Q + + V + I L P + + + +G +
Sbjct: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
Query: 818 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 868
+ G + T + + ++W P + G + Y + + + P
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
Query: 869 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919
T+ E + +++H G +Y+F + AR GFG+ + EI+ P+
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
Score = 31.6 bits (70), Expect = 7.8
Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 34/285 (11%)
Query: 1030 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1076
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 1077 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1131
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 1132 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1190
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 1191 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1249
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 1250 VVSMDLDPQPIT--DEEEGLI-WVVGPVLAVVFIICIVIAILLYK 1291
P ++ EE GLI + LAV+ ++ I +++ K
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 448 bits (1152), Expect = e-125
Identities = 313/960 (32%), Positives = 463/960 (48%), Gaps = 107/960 (11%)
Query: 1030 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1076
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 1077 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1131
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 1132 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1190
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 1191 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1249
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 1250 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1293
P ++ EE GLI + LAV+ ++ I +++ K K
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
Query: 1294 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1318
D R + + P P
Sbjct: 788 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
Query: 1319 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1378
+ + T + HP + + +L HI ++K + F QEYES G W+ + +
Sbjct: 848 CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
Query: 1379 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1432
+R + AYD RV L + G P +DY+NANYID GY + N +IATQG
Sbjct: 902 DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961
Query: 1433 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1492
PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+G +++ L+ T LA
Sbjct: 962 PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020
Query: 1493 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1552
Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RRVK PPDAGP+V+H
Sbjct: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
Query: 1553 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1612
CSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+QTE+QYIFIHDA+LEA
Sbjct: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
Query: 1613 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1670
CG T +P A +++ +I+ N + + EF+ L S A LP N+
Sbjct: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
Query: 1671 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1728
KNR ++++P + CL + +G ++YINA+ D Y + A+I T PL TT DF
Sbjct: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
Query: 1729 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1787
WR+++++ T +VML +L + C QYWP +Y V+ M+ + R F
Sbjct: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317
Query: 1788 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1844
+V + Q VR FQF W + P S + F+ + +V K + + G DG VHC
Sbjct: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376
Query: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1904
G GR+G F + VLE +R +VD+F K LR +P MV+T DQY F Y ALEYL
Sbjct: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
Score = 63.9 bits (154), Expect = 1e-09
Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)
Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626
+ L P + Y F + AR+ +G G A+ EI+ T S PS D+ S S +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
Query: 627 LVSWQP 632
V +P
Sbjct: 609 TVLLRP 614
Score = 62.4 bits (150), Expect = 4e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
Score = 59.7 bits (143), Expect = 3e-08
Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)
Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
+ E G S Y ++ L P + RL +P+G E++ +T + PS + +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
Query: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675
P I + W+ P ++ NG+IT+Y I Y +++ D P + + T ++
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
Query: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712
L T Y +V A T G G +L+ I TN PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
Score = 54.7 bits (130), Expect = 9e-07
Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)
Query: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
+Y+L L P++ Y + P G G + +RT ++P P+ ++ + +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
Query: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684
+ W+P V + + YT + E + ++Y ++ L +
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
Query: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740
+ + G E V +T+EDVPSG + E++ T ++ + W P +
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
Query: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 800
+G I Y++ Y +E+ +P ++ + E T H + S L P T+Y +V
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567
Query: 801 TAYTTKGDGARSKPKLVSTTGA 822
A T KG G + ++ + A
Sbjct: 568 RARTGKGFGQAALTEITTNISA 589
Score = 52.0 bits (123), Expect = 6e-06
Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)
Query: 790 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 844
L P+T Y ++V T GDG R P L+S T L Q +QW
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
Query: 845 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 897
P T+ Y G + + +E+ +T ++ + RL
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
Query: 898 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 957
N G E E+VP+G + + L W+ P E NG+IT+Y +
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
Query: 958 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 1003
Y+ I N+P + +T + L P TTY VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
Score = 43.9 bits (102), Expect = 0.002
Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)
Query: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
+R +++P+G G S AE+ + + P APPQ + T +++ + +G
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
Query: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699
I I+Y G + H + Y L L+ TEY I+V T D G G
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
Query: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757
++ RT P P+ + + + + + W N + H HY G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
Query: 758 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 817
Q + + V + I L P + + + +G +
Sbjct: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
Query: 818 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 868
+ G + T + + ++W P + G + Y + + + P
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
Query: 869 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919
T+ E + +++H G +Y+F + AR GFG+ + EI+ P+
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 424 bits (1089), Expect = e-118
Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)
Query: 1328 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 1367
+P + S PP PI ++D H+ L A+ +F QE +S
Sbjct: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737
Query: 1368 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1425
T + SN NK KNRY N++AYDHSRV L+ + G +DY+NANY+DGY + AY
Sbjct: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797
Query: 1426 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1485
IA QG L T DFWRMIWE +VM+T L E+ R KCDQYWP+ G+E +G VT
Sbjct: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857
Query: 1486 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1537
LA Y VR F L K GS + R V Q+ +T WPD GVPE+ P L F+R+
Sbjct: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917
Query: 1538 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1597
GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G + +R+QRNY+VQ
Sbjct: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977
Query: 1598 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1657
TE+QY+FIHD L+EA+ TEV +++AY+ L I T +E +F+ L+ S
Sbjct: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036
Query: 1658 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1717
S + +A CN+ KNR +I+P E +RV + + G EG+DYINAS+I GY Q +I T
Sbjct: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
Query: 1718 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1776
Q PL T +DFWRM+W+HN+ +VVM+ + M ++ YWP + + F V MAE
Sbjct: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154
Query: 1777 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1831
N + I+++F + +D VR FQ WP P S + I + +
Sbjct: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210
Query: 1832 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1891
E +DGP+ VH G G F L+ ++ ++ E VD++Q KM+ RP + +
Sbjct: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270
Query: 1892 QYQFSYRAALEYLGS 1906
QYQF Y+ L + +
Sbjct: 2271 QYQFLYKVILSLVST 2285
Score = 115 bits (288), Expect = 4e-25
Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 1368 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1427
QQ + + + N+ KNR +++I + SRV +S++ G G+DY+NA+YI GY + N +I
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
Query: 1428 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1486
TQ L T DFWRMIW+ + VVM+ + + + YWP++ + +VTL+
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
Query: 1487 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1541
++ F L EVR FQ WP+ P T L + + +
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
Query: 1542 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1601
N GPM+VH G G F + ++ +++ E +VD+Y ++ R + +Q
Sbjct: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
Query: 1602 YIFIHDALLEAVTCGNTEVPARNL 1625
Y F++ +L V+ E P+ +L
Sbjct: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Score = 39.7 bits (91), Expect = 0.029
Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 610 SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEIL 663
S+ P+++ + TS+LV+W+ P V +I ++++ Y +DGED HE L
Sbjct: 312 SSEPENVQADPENYTSLLVTWERPRVVYDT-MIEKFAVLYQQLDGEDQTKHEFL 364
Score = 35.0 bits (79), Expect = 0.70
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)
Query: 518 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 570
+P N +A+PE+ TS+L++W PR I + ++Y+ DGE + +
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
Query: 571 RLQGLKPNSLYYFRLAARSPQGL 593
L L PN Y ++ A GL
Sbjct: 374 ILNNLLPNMSYVLQIVAICTNGL 396
Score = 33.1 bits (74), Expect = 2.7
Identities = 56/231 (24%), Positives = 90/231 (38%), Gaps = 30/231 (12%)
Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 468
E SS P +VQA + T++LV W+ P + I+ + V Y D T+H ++
Sbjct: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365
Query: 469 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVP---------GQ 518
D + NL+P +Y ++++A + G G S + V T P G
Sbjct: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGT 424
Query: 519 PLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPN 578
K E E + + P D+ N ++ K+ + I T Y G K N
Sbjct: 425 EEIIKEEEEGKDIEEGAIVNPGRDSATN-QIRKKEPQ--------ISTTTHYNRIGTKYN 475
Query: 579 SLYYFRLAARSPQGLGASTAEISARTMQSKP---SAPPQDISCTSPSSTSI 626
R R + G ++ S+P A +DIS TS + T +
Sbjct: 476 EAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTEL 526
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 1336 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1394
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 582 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
Query: 1395 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1454
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 642 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
Query: 1455 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1511
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 702 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761
Query: 1512 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1571
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 762 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821
Query: 1572 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1631
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 822 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881
Query: 1632 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1689
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 882 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940
Query: 1690 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1732
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 941 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
Query: 1733 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1792
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
Query: 1793 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1844
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
Query: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1897
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
Score = 197 bits (501), Expect = 8e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1664 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1723
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 622 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
Query: 1724 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1781
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 682 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
Query: 1782 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1840
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 742 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
Query: 1841 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1900
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 800 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
Query: 1901 LEY 1903
+EY
Sbjct: 860 VEY 862
Score = 156 bits (395), Expect = 2e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 1337 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1391
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 870 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
Query: 1392 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1432
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 930 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
Query: 1433 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1492
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 990 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048
Query: 1493 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1545
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108
Query: 1546 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1602
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168
Query: 1603 IFIHDALLEAVTCGNTEVPARN 1624
F++D + N +V N
Sbjct: 1169 QFLYDVIASTYPAQNGQVKKNN 1190
Score = 39.3 bits (90), Expect = 0.037
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)
Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372
Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605
L Y + E+ + ++ Y LQ LKP + Y L A + + +A + T
Sbjct: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 430
Query: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
+S P + +++ + S S+ V +PP +NG Y ++ A
Sbjct: 431 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 474
Score = 32.3 bits (72), Expect = 4.6
Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)
Query: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
PQ I C S ++ +++W PP N T IK T D L + + KY
Sbjct: 345 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 394
Query: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731
L+ L+ +T+Y +++ A+ + + T + P + V + S+ V
Sbjct: 395 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 454
Query: 732 WRSP 735
R P
Sbjct: 455 CRPP 458
Score = 32.3 bits (72), Expect = 4.6
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)
Query: 787 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 843
+ L+P T Y L++ AY K S TT + P + ++ T N+ ++
Sbjct: 396 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 455
Query: 844 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 901
PP D GP + Y L ++E TL S K F D+ Y F+ N
Sbjct: 456 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 510
Query: 902 GFGEEMV 908
GE +
Sbjct: 511 YPGEPFI 517
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 1336 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1394
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 630 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 689
Query: 1395 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1454
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 690 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 749
Query: 1455 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1511
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 750 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 809
Query: 1512 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1571
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 810 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 869
Query: 1572 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1631
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 870 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 929
Query: 1632 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1689
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 930 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 988
Query: 1690 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1732
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 989 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1048
Query: 1733 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1792
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1049 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1107
Query: 1793 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1844
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1108 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1167
Query: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1897
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1168 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220
Score = 197 bits (501), Expect = 8e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1664 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1723
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 670 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729
Query: 1724 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1781
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 730 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789
Query: 1782 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1840
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 790 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847
Query: 1841 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1900
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 848 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Query: 1901 LEY 1903
+EY
Sbjct: 908 VEY 910
Score = 156 bits (395), Expect = 2e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 1337 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1391
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 918 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 977
Query: 1392 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1432
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 978 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 1037
Query: 1433 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1492
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 1038 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1096
Query: 1493 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1545
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1097 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1156
Query: 1546 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1602
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1157 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1216
Query: 1603 IFIHDALLEAVTCGNTEVPARN 1624
F++D + N +V N
Sbjct: 1217 QFLYDVIASTYPAQNGQVKKNN 1238
Score = 39.3 bits (90), Expect = 0.037
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)
Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 315 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 362
Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 363 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 420
Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605
L Y + E+ + ++ Y LQ LKP + Y L A + + +A + T
Sbjct: 421 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 478
Query: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
+S P + +++ + S S+ V +PP +NG Y ++ A
Sbjct: 479 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 522
Score = 32.3 bits (72), Expect = 4.6
Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)
Query: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
PQ I C S ++ +++W PP N T IK T D L + + KY
Sbjct: 393 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 442
Query: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731
L+ L+ +T+Y +++ A+ + + T + P + V + S+ V
Sbjct: 443 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 502
Query: 732 WRSP 735
R P
Sbjct: 503 CRPP 506
Score = 32.3 bits (72), Expect = 4.6
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)
Query: 787 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 843
+ L+P T Y L++ AY K S TT + P + ++ T N+ ++
Sbjct: 444 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 503
Query: 844 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 901
PP D GP + Y L ++E TL S K F D+ Y F+ N
Sbjct: 504 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 558
Query: 902 GFGEEMV 908
GE +
Sbjct: 559 YPGEPFI 565
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 1336 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1394
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
Query: 1395 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1454
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
Query: 1455 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1511
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648
Query: 1512 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1571
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 649 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708
Query: 1572 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1631
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 709 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768
Query: 1632 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1689
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 769 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827
Query: 1690 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1732
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
Query: 1733 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1792
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 888 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
Query: 1793 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1844
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
Query: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1897
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
Score = 197 bits (501), Expect = 8e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1664 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1723
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
Query: 1724 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1781
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
Query: 1782 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1840
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
Query: 1841 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1900
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
Query: 1901 LEY 1903
+EY
Sbjct: 747 VEY 749
Score = 156 bits (395), Expect = 2e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 1337 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1391
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
Query: 1392 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1432
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
Query: 1433 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1492
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935
Query: 1493 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1545
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 936 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995
Query: 1546 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1602
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 996 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055
Query: 1603 IFIHDALLEAVTCGNTEVPARN 1624
F++D + N +V N
Sbjct: 1056 QFLYDVIASTYPAQNGQVKKNN 1077
Score = 39.3 bits (90), Expect = 0.037
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)
Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259
Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605
L Y + E+ + ++ Y LQ LKP + Y L A + + +A + T
Sbjct: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 317
Query: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
+S P + +++ + S S+ V +PP +NG Y ++ A
Sbjct: 318 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 361
Score = 32.3 bits (72), Expect = 4.6
Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)
Query: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
PQ I C S ++ +++W PP N T IK T D L + + KY
Sbjct: 232 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 281
Query: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731
L+ L+ +T+Y +++ A+ + + T + P + V + S+ V
Sbjct: 282 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 341
Query: 732 WRSP 735
R P
Sbjct: 342 CRPP 345
Score = 32.3 bits (72), Expect = 4.6
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)
Query: 787 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 843
+ L+P T Y L++ AY K S TT + P + ++ T N+ ++
Sbjct: 283 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 342
Query: 844 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 901
PP D GP + Y L ++E TL S K F D+ Y F+ N
Sbjct: 343 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 397
Query: 902 GFGEEMV 908
GE +
Sbjct: 398 YPGEPFI 404
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,654,488
Number of Sequences: 37866
Number of extensions: 3831581
Number of successful extensions: 22437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 311
Number of HSP's successfully gapped in prelim test: 229
Number of HSP's that attempted gapping in prelim test: 9479
Number of HSP's gapped (non-prelim): 4141
length of query: 1912
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1795
effective length of database: 13,817,196
effective search space: 24801866820
effective search space used: 24801866820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.