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Search of human proteins with 4506301
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506301 protein tyrosine phosphatase, non-receptor type 9
[Homo sapiens]
(593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506301 protein tyrosine phosphatase, non-receptor type 9 [Ho... 1210 0.0
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 216 5e-56
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 216 5e-56
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 216 5e-56
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 205 1e-52
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 205 1e-52
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 204 2e-52
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 204 2e-52
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 204 2e-52
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 204 2e-52
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 202 9e-52
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 202 9e-52
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 202 9e-52
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 202 9e-52
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 202 9e-52
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 196 7e-50
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 192 1e-48
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 192 1e-48
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 191 2e-48
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 190 4e-48
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 189 5e-48
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 189 5e-48
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 189 5e-48
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 189 8e-48
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 189 8e-48
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 187 3e-47
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 187 3e-47
gi|4506291 protein tyrosine phosphatase, non-receptor type 2 iso... 187 3e-47
gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [H... 187 3e-47
gi|18104980 protein tyrosine phosphatase, non-receptor type 2 is... 187 3e-47
>gi|4506301 protein tyrosine phosphatase, non-receptor type 9 [Homo
sapiens]
Length = 593
Score = 1210 bits (3131), Expect = 0.0
Identities = 593/593 (100%), Positives = 593/593 (100%)
Query: 1 MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR 60
MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR
Sbjct: 1 MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR 60
Query: 61 AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH 120
AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH
Sbjct: 61 AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH 120
Query: 121 KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP 180
KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP
Sbjct: 121 KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP 180
Query: 181 ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK 240
ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK
Sbjct: 181 ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK 240
Query: 241 IDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK 300
IDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK
Sbjct: 241 IDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK 300
Query: 301 QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA 360
QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA
Sbjct: 301 QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA 360
Query: 361 SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK 420
SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK
Sbjct: 361 SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK 420
Query: 421 DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL 480
DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL
Sbjct: 421 DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL 480
Query: 481 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT 540
IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
Sbjct: 481 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT 540
Query: 541 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ 593
LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
Sbjct: 541 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ 593
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 216 bits (550), Expect = 5e-56
Identities = 114/292 (39%), Positives = 160/292 (54%), Gaps = 19/292 (6%)
Query: 288 IQELVDYVNARQKQGIYEEYE---DIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRV 344
+Q++ + + G+ EE++ I+ +N P N++KNR + + RV
Sbjct: 509 LQKIYNKIPGTSNNGLEEEFKKLTSIKIQND--KMRTGNLPANMKKNRVLQIIPYEFNRV 566
Query: 345 KLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRF 404
+ + G TDY+NASF+DGY+QK++YI +QGPL +T DFW M+WE K IVM T
Sbjct: 567 IIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTEL 626
Query: 405 EEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQ 464
EE G+ KC QYWP D + +G +TV E Y L + NT E + RQ+ F
Sbjct: 627 EERGQEKCAQYWP--SDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFH 684
Query: 465 FLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGT 524
F WP+ G+PS +I + V+ QQ Q PI VHCSAG GRTGT
Sbjct: 685 FHGWPEVGIPSDGKGMISIIAAVQKQQQ------------QSGNHPITVHCSAGAGRTGT 732
Query: 525 FCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE 576
FC+L L +++ G L+VFQTV +R QR +QT EQY FCYK + E+ +
Sbjct: 733 FCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Score = 176 bits (445), Expect = 7e-44
Identities = 107/297 (36%), Positives = 149/297 (50%), Gaps = 26/297 (8%)
Query: 286 MTIQELVDYVNARQKQG---IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQT 342
+ + +L + +N R EE+ + T + N EKNRY ++ D +
Sbjct: 212 LPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHS 271
Query: 343 RVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTT 402
RV LT G +DYINASF++GY++KN +I QGP E T DFW M+WEQ IVM T
Sbjct: 272 RVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT 331
Query: 403 RFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN----TEERQKR 458
+E KC QYWP +G + V+ V + Y I T + +R
Sbjct: 332 NLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 389
Query: 459 QVTHFQFLSWPDYGVPSSAASLIDFLRVVR--NQQSLAVSNMGARSKGQCPEPPIVVHCS 516
+T F F SWPD+GVP + ++ FL+ V+ N Q IVVHCS
Sbjct: 390 LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA---------------IVVHCS 434
Query: 517 AGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE 573
AG+GRTGTF +D L + ++V+ VSR+R QR +QT QY F Y+A+LE
Sbjct: 435 AGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 216 bits (550), Expect = 5e-56
Identities = 114/292 (39%), Positives = 160/292 (54%), Gaps = 19/292 (6%)
Query: 288 IQELVDYVNARQKQGIYEEYE---DIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRV 344
+Q++ + + G+ EE++ I+ +N P N++KNR + + RV
Sbjct: 518 LQKIYNKIPGTSNNGLEEEFKKLTSIKIQND--KMRTGNLPANMKKNRVLQIIPYEFNRV 575
Query: 345 KLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRF 404
+ + G TDY+NASF+DGY+QK++YI +QGPL +T DFW M+WE K IVM T
Sbjct: 576 IIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTEL 635
Query: 405 EEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQ 464
EE G+ KC QYWP D + +G +TV E Y L + NT E + RQ+ F
Sbjct: 636 EERGQEKCAQYWP--SDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFH 693
Query: 465 FLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGT 524
F WP+ G+PS +I + V+ QQ Q PI VHCSAG GRTGT
Sbjct: 694 FHGWPEVGIPSDGKGMISIIAAVQKQQQ------------QSGNHPITVHCSAGAGRTGT 741
Query: 525 FCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE 576
FC+L L +++ G L+VFQTV +R QR +QT EQY FCYK + E+ +
Sbjct: 742 FCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 793
Score = 176 bits (445), Expect = 7e-44
Identities = 107/297 (36%), Positives = 149/297 (50%), Gaps = 26/297 (8%)
Query: 286 MTIQELVDYVNARQKQG---IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQT 342
+ + +L + +N R EE+ + T + N EKNRY ++ D +
Sbjct: 221 LPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHS 280
Query: 343 RVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTT 402
RV LT G +DYINASF++GY++KN +I QGP E T DFW M+WEQ IVM T
Sbjct: 281 RVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT 340
Query: 403 RFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN----TEERQKR 458
+E KC QYWP +G + V+ V + Y I T + +R
Sbjct: 341 NLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 398
Query: 459 QVTHFQFLSWPDYGVPSSAASLIDFLRVVR--NQQSLAVSNMGARSKGQCPEPPIVVHCS 516
+T F F SWPD+GVP + ++ FL+ V+ N Q IVVHCS
Sbjct: 399 LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA---------------IVVHCS 443
Query: 517 AGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE 573
AG+GRTGTF +D L + ++V+ VSR+R QR +QT QY F Y+A+LE
Sbjct: 444 AGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 500
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 216 bits (550), Expect = 5e-56
Identities = 114/292 (39%), Positives = 160/292 (54%), Gaps = 19/292 (6%)
Query: 288 IQELVDYVNARQKQGIYEEYE---DIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRV 344
+Q++ + + G+ EE++ I+ +N P N++KNR + + RV
Sbjct: 509 LQKIYNKIPGTSNNGLEEEFKKLTSIKIQND--KMRTGNLPANMKKNRVLQIIPYEFNRV 566
Query: 345 KLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRF 404
+ + G TDY+NASF+DGY+QK++YI +QGPL +T DFW M+WE K IVM T
Sbjct: 567 IIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTEL 626
Query: 405 EEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQ 464
EE G+ KC QYWP D + +G +TV E Y L + NT E + RQ+ F
Sbjct: 627 EERGQEKCAQYWP--SDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFH 684
Query: 465 FLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGT 524
F WP+ G+PS +I + V+ QQ Q PI VHCSAG GRTGT
Sbjct: 685 FHGWPEVGIPSDGKGMISIIAAVQKQQQ------------QSGNHPITVHCSAGAGRTGT 732
Query: 525 FCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE 576
FC+L L +++ G L+VFQTV +R QR +QT EQY FCYK + E+ +
Sbjct: 733 FCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Score = 176 bits (445), Expect = 7e-44
Identities = 107/297 (36%), Positives = 149/297 (50%), Gaps = 26/297 (8%)
Query: 286 MTIQELVDYVNARQKQG---IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQT 342
+ + +L + +N R EE+ + T + N EKNRY ++ D +
Sbjct: 212 LPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHS 271
Query: 343 RVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTT 402
RV LT G +DYINASF++GY++KN +I QGP E T DFW M+WEQ IVM T
Sbjct: 272 RVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT 331
Query: 403 RFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN----TEERQKR 458
+E KC QYWP +G + V+ V + Y I T + +R
Sbjct: 332 NLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 389
Query: 459 QVTHFQFLSWPDYGVPSSAASLIDFLRVVR--NQQSLAVSNMGARSKGQCPEPPIVVHCS 516
+T F F SWPD+GVP + ++ FL+ V+ N Q IVVHCS
Sbjct: 390 LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA---------------IVVHCS 434
Query: 517 AGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE 573
AG+GRTGTF +D L + ++V+ VSR+R QR +QT QY F Y+A+LE
Sbjct: 435 AGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 205 bits (521), Expect = 1e-52
Identities = 120/329 (36%), Positives = 174/329 (52%), Gaps = 33/329 (10%)
Query: 279 HVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPC 338
H P P + + ++ + A +EYE I T+ S N KNRY +V
Sbjct: 1329 HPPIP-ITDLADNIERLKANDGLKFSQEYESIDPGQQF-TWENSNLEVNKPKNRYANVIA 1386
Query: 339 LDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVI 398
D +RV LT G +DYINA+++DGY+++NAYI TQGPL T DFW MVWEQ+ +
Sbjct: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446
Query: 399 VMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKR 458
VM TR EE R KC QYWP G + VT L + Y T +H + +KR
Sbjct: 1447 VMMTRLEEKSRVKCDQYWPARGTETC--GLIQVTLLDTVELATYTVRTFALHKSGSSEKR 1504
Query: 459 QVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAG 518
++ FQF++WPD+GVP ++ FLR V+ L P+VVHCSAG
Sbjct: 1505 ELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAG-------------PMVVHCSAG 1551
Query: 519 IGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA--- 575
+GRTG F +D L +++ T++++ V+ MR+QR + +QT +QY F ++A+LE A
Sbjct: 1552 VGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG 1611
Query: 576 -------------EKEGMVSSGQNLLAVE 591
+K G V G+++ A+E
Sbjct: 1612 HTEVPARNLYAHIQKLGQVPPGESVTAME 1640
Score = 199 bits (507), Expect = 5e-51
Identities = 104/250 (41%), Positives = 142/250 (56%), Gaps = 13/250 (5%)
Query: 325 PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYR 384
P N KNR ++ + TRV L G +DYINASF+DGY+Q+ AYI TQGPL +
Sbjct: 1662 PCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTE 1721
Query: 385 DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKK 444
DFW M+WE +IVM T+ E GR KC QYWP E+ + R+ + V + NM Y
Sbjct: 1722 DFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYIL 1779
Query: 445 TTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKG 504
++ + + Q R + FQF WP+ GVP + IDF+ V + G
Sbjct: 1780 REFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTK---------EQFG 1830
Query: 505 QCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQY 564
Q + PI VHCSAG+GRTG F +L I L ++ G +++FQTV +RTQR +QT +QY
Sbjct: 1831 Q--DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQY 1888
Query: 565 YFCYKAILEF 574
CY+A LE+
Sbjct: 1889 QLCYRAALEY 1898
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 205 bits (521), Expect = 1e-52
Identities = 120/329 (36%), Positives = 174/329 (52%), Gaps = 33/329 (10%)
Query: 279 HVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPC 338
H P P + + ++ + A +EYE I T+ S N KNRY +V
Sbjct: 1320 HPPIP-ITDLADNIERLKANDGLKFSQEYESIDPGQQF-TWENSNLEVNKPKNRYANVIA 1377
Query: 339 LDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVI 398
D +RV LT G +DYINA+++DGY+++NAYI TQGPL T DFW MVWEQ+ +
Sbjct: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
Query: 399 VMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKR 458
VM TR EE R KC QYWP G + VT L + Y T +H + +KR
Sbjct: 1438 VMMTRLEEKSRVKCDQYWPARGTETC--GLIQVTLLDTVELATYTVRTFALHKSGSSEKR 1495
Query: 459 QVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAG 518
++ FQF++WPD+GVP ++ FLR V+ L P+VVHCSAG
Sbjct: 1496 ELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAG-------------PMVVHCSAG 1542
Query: 519 IGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA--- 575
+GRTG F +D L +++ T++++ V+ MR+QR + +QT +QY F ++A+LE A
Sbjct: 1543 VGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG 1602
Query: 576 -------------EKEGMVSSGQNLLAVE 591
+K G V G+++ A+E
Sbjct: 1603 HTEVPARNLYAHIQKLGQVPPGESVTAME 1631
Score = 199 bits (507), Expect = 5e-51
Identities = 104/250 (41%), Positives = 142/250 (56%), Gaps = 13/250 (5%)
Query: 325 PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYR 384
P N KNR ++ + TRV L G +DYINASF+DGY+Q+ AYI TQGPL +
Sbjct: 1653 PCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTE 1712
Query: 385 DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKK 444
DFW M+WE +IVM T+ E GR KC QYWP E+ + R+ + V + NM Y
Sbjct: 1713 DFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYIL 1770
Query: 445 TTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKG 504
++ + + Q R + FQF WP+ GVP + IDF+ V + G
Sbjct: 1771 REFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTK---------EQFG 1821
Query: 505 QCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQY 564
Q + PI VHCSAG+GRTG F +L I L ++ G +++FQTV +RTQR +QT +QY
Sbjct: 1822 Q--DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQY 1879
Query: 565 YFCYKAILEF 574
CY+A LE+
Sbjct: 1880 QLCYRAALEY 1889
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 204 bits (518), Expect = 2e-52
Identities = 126/322 (39%), Positives = 171/322 (53%), Gaps = 29/322 (9%)
Query: 257 HP-DPFD-EIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRREN 314
HP DP + I F P L H P P A + E + + A + +EYE I
Sbjct: 907 HPKDPVEMRRINFQTPGMLS----HPPIPIA-DMAEHTERLKANDSLKLSQEYESIDPGQ 961
Query: 315 PVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIG 374
H ++ N KNRY +V D +RV L G +DYINA+++DGY+ +NAYI
Sbjct: 962 QFTWEHSNLEV-NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1020
Query: 375 TQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNL 434
TQGPL T+ DFW MVWEQ+ IVM TR EE R KC QYWP +GF+ VT L
Sbjct: 1021 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTETYGFIQVTLL 1078
Query: 435 GVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLA 494
+ + T +H +KR+V FQF +WPD+GVP + FLR V+
Sbjct: 1079 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT----- 1133
Query: 495 VSNMGARSKGQCPEP---PIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMR 551
C P PIVVHCSAG+GRTG F +D L +++ T++V+ V+ MR
Sbjct: 1134 -----------CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1182
Query: 552 TQRAFSIQTPEQYYFCYKAILE 573
+QR + +QT +QY F ++A+LE
Sbjct: 1183 SQRNYMVQTEDQYSFIHEALLE 1204
Score = 204 bits (518), Expect = 2e-52
Identities = 112/288 (38%), Positives = 155/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1222 IQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1281
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1282 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1341
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1342 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1399
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1400 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1448
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT ++Y FCY+A LE+
Sbjct: 1449 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1496
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 204 bits (518), Expect = 2e-52
Identities = 126/322 (39%), Positives = 171/322 (53%), Gaps = 29/322 (9%)
Query: 257 HP-DPFD-EIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRREN 314
HP DP + I F P L H P P A + E + + A + +EYE I
Sbjct: 1312 HPKDPVEMRRINFQTPGMLS----HPPIPIA-DMAEHTERLKANDSLKLSQEYESIDPGQ 1366
Query: 315 PVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIG 374
H ++ N KNRY +V D +RV L G +DYINA+++DGY+ +NAYI
Sbjct: 1367 QFTWEHSNLEV-NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1425
Query: 375 TQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNL 434
TQGPL T+ DFW MVWEQ+ IVM TR EE R KC QYWP +GF+ VT L
Sbjct: 1426 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTETYGFIQVTLL 1483
Query: 435 GVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLA 494
+ + T +H +KR+V FQF +WPD+GVP + FLR V+
Sbjct: 1484 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT----- 1538
Query: 495 VSNMGARSKGQCPEP---PIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMR 551
C P PIVVHCSAG+GRTG F +D L +++ T++V+ V+ MR
Sbjct: 1539 -----------CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1587
Query: 552 TQRAFSIQTPEQYYFCYKAILE 573
+QR + +QT +QY F ++A+LE
Sbjct: 1588 SQRNYMVQTEDQYSFIHEALLE 1609
Score = 204 bits (518), Expect = 2e-52
Identities = 112/288 (38%), Positives = 155/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1627 IQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1686
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1687 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1746
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1747 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1804
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1805 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1853
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT ++Y FCY+A LE+
Sbjct: 1854 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1901
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 204 bits (518), Expect = 2e-52
Identities = 126/322 (39%), Positives = 171/322 (53%), Gaps = 29/322 (9%)
Query: 257 HP-DPFD-EIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRREN 314
HP DP + I F P L H P P A + E + + A + +EYE I
Sbjct: 903 HPKDPVEMRRINFQTPGMLS----HPPIPIA-DMAEHTERLKANDSLKLSQEYESIDPGQ 957
Query: 315 PVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIG 374
H ++ N KNRY +V D +RV L G +DYINA+++DGY+ +NAYI
Sbjct: 958 QFTWEHSNLEV-NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1016
Query: 375 TQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNL 434
TQGPL T+ DFW MVWEQ+ IVM TR EE R KC QYWP +GF+ VT L
Sbjct: 1017 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTETYGFIQVTLL 1074
Query: 435 GVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLA 494
+ + T +H +KR+V FQF +WPD+GVP + FLR V+
Sbjct: 1075 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT----- 1129
Query: 495 VSNMGARSKGQCPEP---PIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMR 551
C P PIVVHCSAG+GRTG F +D L +++ T++V+ V+ MR
Sbjct: 1130 -----------CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1178
Query: 552 TQRAFSIQTPEQYYFCYKAILE 573
+QR + +QT +QY F ++A+LE
Sbjct: 1179 SQRNYMVQTEDQYSFIHEALLE 1200
Score = 204 bits (518), Expect = 2e-52
Identities = 112/288 (38%), Positives = 155/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1218 IQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1277
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1278 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1337
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1338 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1395
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1396 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1444
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT ++Y FCY+A LE+
Sbjct: 1445 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1492
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 204 bits (518), Expect = 2e-52
Identities = 120/308 (38%), Positives = 167/308 (54%), Gaps = 25/308 (8%)
Query: 271 PALDWDSV--HVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNL 328
P ++S+ H P P A + E + + A + +EYE I H ++ N
Sbjct: 1360 PGFHFESMLSHPPIPIA-DMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEV-NK 1417
Query: 329 EKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWL 388
KNRY +V D +RV L G +DYINA+++DGY+ +NAYI TQGPL T+ DFW
Sbjct: 1418 PKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWR 1477
Query: 389 MVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLE 448
MVWEQ+ IVM TR EE R KC QYWP +GF+ VT L + + T
Sbjct: 1478 MVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTETYGFIQVTLLDTIELATFCVRTFS 1535
Query: 449 IHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPE 508
+H +KR+V FQF +WPD+GVP + FLR V+ C
Sbjct: 1536 LHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT----------------CNP 1579
Query: 509 P---PIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYY 565
P PIVVHCSAG+GRTG F +D L +++ T++V+ V+ MR+QR + +QT +QY
Sbjct: 1580 PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYS 1639
Query: 566 FCYKAILE 573
F ++A+LE
Sbjct: 1640 FIHEALLE 1647
Score = 204 bits (518), Expect = 2e-52
Identities = 112/288 (38%), Positives = 155/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1665 IQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1724
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1725 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1784
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1785 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1842
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1843 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1891
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT ++Y FCY+A LE+
Sbjct: 1892 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1939
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 202 bits (513), Expect = 9e-52
Identities = 112/288 (38%), Positives = 154/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1219 IQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1278
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1279 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLRE 1338
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1339 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1396
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1397 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1445
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT +QY F Y+A LE+
Sbjct: 1446 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1493
Score = 195 bits (495), Expect = 1e-49
Identities = 116/335 (34%), Positives = 170/335 (50%), Gaps = 45/335 (13%)
Query: 279 HVPGPHAMTIQELVDYVN---ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGD 335
H P P I EL D++ A +EYE I H ++ N KNRY +
Sbjct: 924 HPPIP----ILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEV-NKPKNRYAN 978
Query: 336 VPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKV 395
V D +RV L+ G +DY+NA+++DGY+++NAYI TQG L T+ DFW M+WEQ+
Sbjct: 979 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1038
Query: 396 LVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER 455
+VM T+ EE R KC QYWP G + VT L + Y T ++
Sbjct: 1039 ATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYKNGSS 1096
Query: 456 QKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP---PIV 512
+KR+V FQF +WPD+GVP + FLR V+ C P P+V
Sbjct: 1097 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT----------------CNPPDAGPMV 1140
Query: 513 VHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAIL 572
VHCSAG+GRTG F +D L +++ T++++ V+ MR QR + +QT +QY F + A+L
Sbjct: 1141 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1200
Query: 573 E----------------FAEKEGMVSSGQNLLAVE 591
E + +K + +G+N+ +E
Sbjct: 1201 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGME 1235
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 202 bits (513), Expect = 9e-52
Identities = 112/288 (38%), Positives = 154/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1629 IQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1688
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1689 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLRE 1748
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1749 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1806
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1807 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1855
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT +QY F Y+A LE+
Sbjct: 1856 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1903
Score = 195 bits (495), Expect = 1e-49
Identities = 116/335 (34%), Positives = 170/335 (50%), Gaps = 45/335 (13%)
Query: 279 HVPGPHAMTIQELVDYVN---ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGD 335
H P P I EL D++ A +EYE I H ++ N KNRY +
Sbjct: 1334 HPPIP----ILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEV-NKPKNRYAN 1388
Query: 336 VPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKV 395
V D +RV L+ G +DY+NA+++DGY+++NAYI TQG L T+ DFW M+WEQ+
Sbjct: 1389 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1448
Query: 396 LVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER 455
+VM T+ EE R KC QYWP G + VT L + Y T ++
Sbjct: 1449 ATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYKNGSS 1506
Query: 456 QKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP---PIV 512
+KR+V FQF +WPD+GVP + FLR V+ C P P+V
Sbjct: 1507 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT----------------CNPPDAGPMV 1550
Query: 513 VHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAIL 572
VHCSAG+GRTG F +D L +++ T++++ V+ MR QR + +QT +QY F + A+L
Sbjct: 1551 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1610
Query: 573 E----------------FAEKEGMVSSGQNLLAVE 591
E + +K + +G+N+ +E
Sbjct: 1611 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGME 1645
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 202 bits (513), Expect = 9e-52
Identities = 112/288 (38%), Positives = 154/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1616 IQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1675
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1676 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLRE 1735
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1736 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1793
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1794 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1842
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT +QY F Y+A LE+
Sbjct: 1843 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1890
Score = 195 bits (495), Expect = 1e-49
Identities = 116/335 (34%), Positives = 170/335 (50%), Gaps = 45/335 (13%)
Query: 279 HVPGPHAMTIQELVDYVN---ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGD 335
H P P I EL D++ A +EYE I H ++ N KNRY +
Sbjct: 1321 HPPIP----ILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEV-NKPKNRYAN 1375
Query: 336 VPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKV 395
V D +RV L+ G +DY+NA+++DGY+++NAYI TQG L T+ DFW M+WEQ+
Sbjct: 1376 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1435
Query: 396 LVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER 455
+VM T+ EE R KC QYWP G + VT L + Y T ++
Sbjct: 1436 ATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYKNGSS 1493
Query: 456 QKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP---PIV 512
+KR+V FQF +WPD+GVP + FLR V+ C P P+V
Sbjct: 1494 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT----------------CNPPDAGPMV 1537
Query: 513 VHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAIL 572
VHCSAG+GRTG F +D L +++ T++++ V+ MR QR + +QT +QY F + A+L
Sbjct: 1538 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1597
Query: 573 E----------------FAEKEGMVSSGQNLLAVE 591
E + +K + +G+N+ +E
Sbjct: 1598 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGME 1632
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 202 bits (513), Expect = 9e-52
Identities = 112/288 (38%), Positives = 154/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1620 IQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1679
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1680 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLRE 1739
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1740 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1797
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1798 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1846
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT +QY F Y+A LE+
Sbjct: 1847 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1894
Score = 195 bits (495), Expect = 1e-49
Identities = 116/335 (34%), Positives = 170/335 (50%), Gaps = 45/335 (13%)
Query: 279 HVPGPHAMTIQELVDYVN---ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGD 335
H P P I EL D++ A +EYE I H ++ N KNRY +
Sbjct: 1325 HPPIP----ILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEV-NKPKNRYAN 1379
Query: 336 VPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKV 395
V D +RV L+ G +DY+NA+++DGY+++NAYI TQG L T+ DFW M+WEQ+
Sbjct: 1380 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1439
Query: 396 LVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER 455
+VM T+ EE R KC QYWP G + VT L + Y T ++
Sbjct: 1440 ATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYKNGSS 1497
Query: 456 QKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP---PIV 512
+KR+V FQF +WPD+GVP + FLR V+ C P P+V
Sbjct: 1498 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT----------------CNPPDAGPMV 1541
Query: 513 VHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAIL 572
VHCSAG+GRTG F +D L +++ T++++ V+ MR QR + +QT +QY F + A+L
Sbjct: 1542 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1601
Query: 573 E----------------FAEKEGMVSSGQNLLAVE 591
E + +K + +G+N+ +E
Sbjct: 1602 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGME 1636
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 202 bits (513), Expect = 9e-52
Identities = 112/288 (38%), Positives = 154/288 (53%), Gaps = 14/288 (4%)
Query: 288 IQELVDYVNARQKQGIYEEYEDIRRENP-VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKL 346
IQ+L G+ E++ + F + P N KNR ++ + TRV L
Sbjct: 1218 IQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1277
Query: 347 TKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEE 406
G +DYINASF+DGY+Q+ AYI TQGPL T DFW M+WE ++VM T+ E
Sbjct: 1278 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLRE 1337
Query: 407 GGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL 466
GR KC QYWP E+ + R+ + V + NM Y ++ + + Q R V FQF
Sbjct: 1338 MGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1395
Query: 467 SWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFC 526
WP+ GVP S IDF+ V + GQ + PI VHCSAG+GRTG F
Sbjct: 1396 DWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPISVHCSAGVGRTGVFI 1444
Query: 527 SLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+L I L ++ G +++FQTV +RTQR +QT +QY F Y+A LE+
Sbjct: 1445 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1492
Score = 195 bits (495), Expect = 1e-49
Identities = 116/335 (34%), Positives = 170/335 (50%), Gaps = 45/335 (13%)
Query: 279 HVPGPHAMTIQELVDYVN---ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGD 335
H P P I EL D++ A +EYE I H ++ N KNRY +
Sbjct: 923 HPPIP----ILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEV-NKPKNRYAN 977
Query: 336 VPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKV 395
V D +RV L+ G +DY+NA+++DGY+++NAYI TQG L T+ DFW M+WEQ+
Sbjct: 978 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1037
Query: 396 LVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER 455
+VM T+ EE R KC QYWP G + VT L + Y T ++
Sbjct: 1038 ATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYKNGSS 1095
Query: 456 QKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP---PIV 512
+KR+V FQF +WPD+GVP + FLR V+ C P P+V
Sbjct: 1096 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT----------------CNPPDAGPMV 1139
Query: 513 VHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAIL 572
VHCSAG+GRTG F +D L +++ T++++ V+ MR QR + +QT +QY F + A+L
Sbjct: 1140 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1199
Query: 573 E----------------FAEKEGMVSSGQNLLAVE 591
E + +K + +G+N+ +E
Sbjct: 1200 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGME 1234
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 196 bits (497), Expect = 7e-50
Identities = 117/322 (36%), Positives = 172/322 (53%), Gaps = 38/322 (11%)
Query: 285 AMTIQELVDYVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPC 338
A+ +++ V ++ + + G E++E+++R + + H S P N KNRY ++
Sbjct: 827 AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILA 885
Query: 339 LDQTRVKLTKRSGHTQ--TDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVL 396
D +RVKL G +DYINA+++DGY + AYI TQGPL++T+ DFW M+WEQ
Sbjct: 886 YDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTG 945
Query: 397 VIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTE--- 453
+IVM T E GRRKC QYWP E +G + VT + Y I NT+
Sbjct: 946 IIVMITNLVEKGRRKCDQYWPTENSE--EYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK 1003
Query: 454 --------ERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQ 505
+ +R V + + WPD GVP A ++ F+R S +
Sbjct: 1004 GQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVR--------------RSSAAR 1049
Query: 506 CPEP-PIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQY 564
PE P++VHCSAG+GRTGT+ +D L Q+++ T+NV + +RTQR + +QT EQY
Sbjct: 1050 MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQY 1109
Query: 565 YFCYKAILE-FAEKEGMVSSGQ 585
F + A+LE KE VSS Q
Sbjct: 1110 IFIHDALLEAILGKETEVSSNQ 1131
Score = 110 bits (275), Expect = 4e-24
Identities = 79/251 (31%), Positives = 117/251 (46%), Gaps = 22/251 (8%)
Query: 327 NLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDF 386
N EKNR V ++ RV L G TDYINAS++ GY + N +I TQ PL +T +DF
Sbjct: 1175 NKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDF 1234
Query: 387 WLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTT 446
W M+W+ +IVM + + YWP ++S F TVT + + + +
Sbjct: 1235 WRMIWDHNAQIIVMLPDNQSLAEDEF-VYWPSREESMNCEAF-TVTLISKDRLCLSNEEQ 1292
Query: 447 LEIHN-----TEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGAR 501
+ IH+ T++ +V HFQ WP+ P S S + + V++ + A++ G
Sbjct: 1293 IIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPIS--STFELINVIKEE---ALTRDG-- 1345
Query: 502 SKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTP 561
P +VH G G C+L QLE ++VFQ + R
Sbjct: 1346 --------PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDI 1397
Query: 562 EQYYFCYKAIL 572
EQY F YKA+L
Sbjct: 1398 EQYQFIYKAML 1408
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 192 bits (487), Expect = 1e-48
Identities = 108/293 (36%), Positives = 156/293 (53%), Gaps = 22/293 (7%)
Query: 285 AMTIQELVDYVNARQK---QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQ 341
A+ + +L+ ++ ++ G EEYE + E ++ + N KNRYG++ D
Sbjct: 868 AIRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRNKNRYGNIISYDH 926
Query: 342 TRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMT 401
+RV+L G +DYINA+++DGY + YI TQGP++ T +DFW M+W++ IVM
Sbjct: 927 SRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV 986
Query: 402 TRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVT 461
T E GR KC +YWP D +G + VT + E + Y T + + R++
Sbjct: 987 TNLVEVGRVKCVRYWP---DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELR 1043
Query: 462 HFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVVHCSAGIG 520
F F SWPD+GVP A L+ F+R V+ PE PIVVHCSAG G
Sbjct: 1044 LFHFTSWPDHGVPCYATGLLGFVRQVKFLNP--------------PEAGPIVVHCSAGAG 1089
Query: 521 RTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE 573
RTG F ++D L E G +++F V +R QR +QT EQY F + AILE
Sbjct: 1090 RTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1142
Score = 117 bits (294), Expect = 2e-26
Identities = 90/278 (32%), Positives = 134/278 (48%), Gaps = 21/278 (7%)
Query: 303 IYEEYEDIRRENP-VGTFHCSMS--PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYIN 359
I +E++ + P V CS+ P N +KNR DV LD+ L G + ++YIN
Sbjct: 1175 IKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYIN 1233
Query: 360 ASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLE 419
A+ MD +KQ A++ TQ PL NT DFW +V++ +VM + + C QYWP E
Sbjct: 1234 AALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA--QFCMQYWP-E 1290
Query: 420 KDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQK--RQVTHFQFLSWPDY-GVPSS 476
K S +G + V + + I N Q R V H Q++ WP Y P S
Sbjct: 1291 KTSGC-YGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPS 1349
Query: 477 AASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLE 536
SL L+VVR + G + VVHC G GR+GTFC++ ++
Sbjct: 1350 KRSL---LKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQ 1399
Query: 537 ELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+ ++VF V +R ++ ++T EQY F Y+ LE+
Sbjct: 1400 QQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1437
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 192 bits (487), Expect = 1e-48
Identities = 108/293 (36%), Positives = 156/293 (53%), Gaps = 22/293 (7%)
Query: 285 AMTIQELVDYVNARQK---QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQ 341
A+ + +L+ ++ ++ G EEYE + E ++ + N KNRYG++ D
Sbjct: 887 AIRVADLLQHITQMKRGQGYGFKEEYEALP-EGQTASWDTAKEDENRNKNRYGNIISYDH 945
Query: 342 TRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMT 401
+RV+L G +DYINA+++DGY + YI TQGP++ T +DFW M+W++ IVM
Sbjct: 946 SRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV 1005
Query: 402 TRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVT 461
T E GR KC +YWP D +G + VT + E + Y T + + R++
Sbjct: 1006 TNLVEVGRVKCVRYWP---DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELR 1062
Query: 462 HFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVVHCSAGIG 520
F F SWPD+GVP A L+ F+R V+ PE PIVVHCSAG G
Sbjct: 1063 LFHFTSWPDHGVPCYATGLLGFVRQVKFLNP--------------PEAGPIVVHCSAGAG 1108
Query: 521 RTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE 573
RTG F ++D L E G +++F V +R QR +QT EQY F + AILE
Sbjct: 1109 RTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1161
Score = 117 bits (294), Expect = 2e-26
Identities = 90/278 (32%), Positives = 134/278 (48%), Gaps = 21/278 (7%)
Query: 303 IYEEYEDIRRENP-VGTFHCSMS--PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYIN 359
I +E++ + P V CS+ P N +KNR DV LD+ L G + ++YIN
Sbjct: 1194 IKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYIN 1252
Query: 360 ASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLE 419
A+ MD +KQ A++ TQ PL NT DFW +V++ +VM + + C QYWP E
Sbjct: 1253 AALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA--QFCMQYWP-E 1309
Query: 420 KDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQK--RQVTHFQFLSWPDY-GVPSS 476
K S +G + V + + I N Q R V H Q++ WP Y P S
Sbjct: 1310 KTSGC-YGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPS 1368
Query: 477 AASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLE 536
SL L+VVR + G + VVHC G GR+GTFC++ ++
Sbjct: 1369 KRSL---LKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQ 1418
Query: 537 ELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
+ ++VF V +R ++ ++T EQY F Y+ LE+
Sbjct: 1419 QQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1456
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 191 bits (485), Expect = 2e-48
Identities = 104/266 (39%), Positives = 145/266 (54%), Gaps = 25/266 (9%)
Query: 318 TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK--RSGHTQTDYINASFMDGYKQKNAYIGT 375
T S P N KNRY ++ D +RVKL + TDYINA+++DGY + AYI
Sbjct: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAA 1800
Query: 376 QGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLG 435
QGPL++T DFW M+WE V VIVM T E GRRKC QYWP D +G VT
Sbjct: 1801 QGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSEEYGNFLVTQKS 1858
Query: 436 VENMNHYKKTTLEIHNTEERQKRQ--------VTHFQFLSWPDYGVPSSAASLIDFLRVV 487
V+ + +Y + NT+ ++ Q VT + + WPD GVP + ++ F+R
Sbjct: 1859 VQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA 1918
Query: 488 RNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTV 547
+ AV P+VVHCSAG+GRTGT+ LD L Q++ GT+N+F +
Sbjct: 1919 AYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFL 1965
Query: 548 SRMRTQRAFSIQTPEQYYFCYKAILE 573
+R+QR + +QT EQY F + ++E
Sbjct: 1966 KHIRSQRNYLVQTEEQYVFIHDTLVE 1991
Score = 111 bits (277), Expect = 2e-24
Identities = 78/259 (30%), Positives = 128/259 (49%), Gaps = 23/259 (8%)
Query: 319 FHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGP 378
+ ++ N EKNR + ++++RV ++ SG TDYINAS++ GY Q N +I TQ P
Sbjct: 2040 YSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHP 2098
Query: 379 LENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVEN 438
L +T +DFW M+W+ ++VM + + YWP KD I VT + E+
Sbjct: 2099 LLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWP-NKDEPINCESFKVTLMAEEH 2156
Query: 439 --MNHYKKTTLE---IHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSL 493
+++ +K ++ + T++ +V HFQ WP+ P S + + V++ +
Sbjct: 2157 KCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS--KTFELISVIKEE--- 2211
Query: 494 AVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQ 553
A + G P++VH G GTFC+L + QLE+ +++V+Q +
Sbjct: 2212 AANRDG----------PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLM 2261
Query: 554 RAFSIQTPEQYYFCYKAIL 572
R EQY F YK IL
Sbjct: 2262 RPGVFADIEQYQFLYKVIL 2280
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 190 bits (482), Expect = 4e-48
Identities = 103/277 (37%), Positives = 152/277 (54%), Gaps = 14/277 (5%)
Query: 302 GIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINAS 361
G EEYED++ + + N KNRY +V D +RVKL+ ++ H+ DYINA+
Sbjct: 1040 GFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINAN 1098
Query: 362 FMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD 421
+M GY K +I TQGPL NT +DFW MVWE+ V I+M T+ E GR KC +YWP ++
Sbjct: 1099 YMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA 1158
Query: 422 SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLI 481
+G +TV + + + N + + + F F SWPD+GVP + LI
Sbjct: 1159 Q--DYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLI 1216
Query: 482 DFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTL 541
+F +VR+ K PE PI+VHCSAG+GRTGTF ++D + Q+E T+
Sbjct: 1217 NFRYLVRDYM-----------KQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTV 1265
Query: 542 NVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKE 578
+V+ V +R R +QT +QY F + +L+ +
Sbjct: 1266 DVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQ 1302
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform
3 precursor [Homo sapiens]
Length = 1256
Score = 189 bits (481), Expect = 5e-48
Identities = 104/251 (41%), Positives = 142/251 (56%), Gaps = 14/251 (5%)
Query: 325 PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYR 384
P N KNRY D+ D RV+L++ +G ++YINAS++DG+K+ YI QGP + T
Sbjct: 625 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684
Query: 385 DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKK 444
DFW M+WEQK VIVM TR EEG R KC +YWP ++ FG + V + Y
Sbjct: 685 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744
Query: 445 TTLEIHNTEERQK-RQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSK 503
L I N +E+ R+VTH QF SWPD+GVP L+ R V A SN +
Sbjct: 745 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVN-----AFSNFFS--- 796
Query: 504 GQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQ 563
PIVVHCSAG+GRTGT+ +D L LE ++V+ V ++R QR +Q Q
Sbjct: 797 -----GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQ 851
Query: 564 YYFCYKAILEF 574
Y ++A++E+
Sbjct: 852 YILIHQALVEY 862
Score = 128 bits (321), Expect = 2e-29
Identities = 90/316 (28%), Positives = 141/316 (44%), Gaps = 32/316 (10%)
Query: 282 GPHAMTIQELVDYVNARQKQG-------IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYG 334
G + + EL Y++ +K+ + E++ + T H N KNR
Sbjct: 866 GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNS 925
Query: 335 DVPCLDQTRVKL------TKRSGHTQTD-------------YINASFMDGYKQKNAYIGT 375
+V D RV L +K S H + YINASF+ Y + I
Sbjct: 926 NVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAA 985
Query: 376 QGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLG 435
QGPL+ T DFW M++++KV VIVM T + G + C QYW K + +G + V
Sbjct: 986 QGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT---YGDIEVDLKD 1042
Query: 436 VENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAV 495
+ + Y E+ +++ + R V +Q+ +W +P+ LI ++VV+ Q L
Sbjct: 1043 TDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK--QKLPQ 1100
Query: 496 SNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRA 555
N +K P+++HC G +TG FC+L L E +++FQ V +R R
Sbjct: 1101 KNSSEGNKHH-KSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARP 1159
Query: 556 FSIQTPEQYYFCYKAI 571
+ T EQY F Y I
Sbjct: 1160 GMVSTFEQYQFLYDVI 1175
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform
1 precursor [Homo sapiens]
Length = 1304
Score = 189 bits (481), Expect = 5e-48
Identities = 104/251 (41%), Positives = 142/251 (56%), Gaps = 14/251 (5%)
Query: 325 PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYR 384
P N KNRY D+ D RV+L++ +G ++YINAS++DG+K+ YI QGP + T
Sbjct: 673 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 732
Query: 385 DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKK 444
DFW M+WEQK VIVM TR EEG R KC +YWP ++ FG + V + Y
Sbjct: 733 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 792
Query: 445 TTLEIHNTEERQK-RQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSK 503
L I N +E+ R+VTH QF SWPD+GVP L+ R V A SN +
Sbjct: 793 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVN-----AFSNFFS--- 844
Query: 504 GQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQ 563
PIVVHCSAG+GRTGT+ +D L LE ++V+ V ++R QR +Q Q
Sbjct: 845 -----GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQ 899
Query: 564 YYFCYKAILEF 574
Y ++A++E+
Sbjct: 900 YILIHQALVEY 910
Score = 128 bits (321), Expect = 2e-29
Identities = 90/316 (28%), Positives = 141/316 (44%), Gaps = 32/316 (10%)
Query: 282 GPHAMTIQELVDYVNARQKQG-------IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYG 334
G + + EL Y++ +K+ + E++ + T H N KNR
Sbjct: 914 GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNS 973
Query: 335 DVPCLDQTRVKL------TKRSGHTQTD-------------YINASFMDGYKQKNAYIGT 375
+V D RV L +K S H + YINASF+ Y + I
Sbjct: 974 NVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAA 1033
Query: 376 QGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLG 435
QGPL+ T DFW M++++KV VIVM T + G + C QYW K + +G + V
Sbjct: 1034 QGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT---YGDIEVDLKD 1090
Query: 436 VENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAV 495
+ + Y E+ +++ + R V +Q+ +W +P+ LI ++VV+ Q L
Sbjct: 1091 TDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK--QKLPQ 1148
Query: 496 SNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRA 555
N +K P+++HC G +TG FC+L L E +++FQ V +R R
Sbjct: 1149 KNSSEGNKHH-KSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARP 1207
Query: 556 FSIQTPEQYYFCYKAI 571
+ T EQY F Y I
Sbjct: 1208 GMVSTFEQYQFLYDVI 1223
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform
2 precursor [Homo sapiens]
Length = 1143
Score = 189 bits (481), Expect = 5e-48
Identities = 104/251 (41%), Positives = 142/251 (56%), Gaps = 14/251 (5%)
Query: 325 PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYR 384
P N KNRY D+ D RV+L++ +G ++YINAS++DG+K+ YI QGP + T
Sbjct: 512 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571
Query: 385 DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKK 444
DFW M+WEQK VIVM TR EEG R KC +YWP ++ FG + V + Y
Sbjct: 572 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631
Query: 445 TTLEIHNTEERQK-RQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSK 503
L I N +E+ R+VTH QF SWPD+GVP L+ R V A SN +
Sbjct: 632 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVN-----AFSNFFS--- 683
Query: 504 GQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQ 563
PIVVHCSAG+GRTGT+ +D L LE ++V+ V ++R QR +Q Q
Sbjct: 684 -----GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQ 738
Query: 564 YYFCYKAILEF 574
Y ++A++E+
Sbjct: 739 YILIHQALVEY 749
Score = 128 bits (321), Expect = 2e-29
Identities = 90/316 (28%), Positives = 141/316 (44%), Gaps = 32/316 (10%)
Query: 282 GPHAMTIQELVDYVNARQKQG-------IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYG 334
G + + EL Y++ +K+ + E++ + T H N KNR
Sbjct: 753 GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNS 812
Query: 335 DVPCLDQTRVKL------TKRSGHTQTD-------------YINASFMDGYKQKNAYIGT 375
+V D RV L +K S H + YINASF+ Y + I
Sbjct: 813 NVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAA 872
Query: 376 QGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLG 435
QGPL+ T DFW M++++KV VIVM T + G + C QYW K + +G + V
Sbjct: 873 QGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT---YGDIEVDLKD 929
Query: 436 VENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAV 495
+ + Y E+ +++ + R V +Q+ +W +P+ LI ++VV+ Q L
Sbjct: 930 TDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK--QKLPQ 987
Query: 496 SNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRA 555
N +K P+++HC G +TG FC+L L E +++FQ V +R R
Sbjct: 988 KNSSEGNKHH-KSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARP 1046
Query: 556 FSIQTPEQYYFCYKAI 571
+ T EQY F Y I
Sbjct: 1047 GMVSTFEQYQFLYDVI 1062
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 189 bits (479), Expect = 8e-48
Identities = 105/292 (35%), Positives = 151/292 (51%), Gaps = 20/292 (6%)
Query: 285 AMTIQELVDYVN---ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQ 341
A+ + +L+ ++ + G EEYE E + + N KNRYG++ D
Sbjct: 879 AIRVADLLQHITQMKCAEGYGFKEEYESFF-EGQSAPWDSAKKDENRMKNRYGNIIAYDH 937
Query: 342 TRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMT 401
+RV+L G T +DYIN +++DGY + N YI TQGP++ T DFW MVW + I+M
Sbjct: 938 SRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMV 997
Query: 402 TRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVT 461
T E GR KC +YWP D + + VT + E + Y T + + R++
Sbjct: 998 TNLVEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIR 1054
Query: 462 HFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGR 521
F F WPD+GVP A L+ F+R V +SK P+VVHCSAG GR
Sbjct: 1055 QFHFTGWPDHGVPYHATGLLGFVRQV-------------KSKSPPSAGPLVVHCSAGAGR 1101
Query: 522 TGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE 573
TG F +DI L E G ++++ V +R++R +QT EQY F + AILE
Sbjct: 1102 TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1153
Score = 125 bits (314), Expect = 1e-28
Identities = 89/277 (32%), Positives = 130/277 (46%), Gaps = 19/277 (6%)
Query: 303 IYEEYEDIRRENP-VGTFHCSMS--PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYIN 359
I EE+ + P + CS++ P N EKNR D+ D+ L G + ++YIN
Sbjct: 1186 IKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYIN 1244
Query: 360 ASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLE 419
A+ MD YKQ +A+I TQ PL NT +DFW +V + +VM + + C QYWP
Sbjct: 1245 AALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP-- 1300
Query: 420 KDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQK--RQVTHFQFLSWPDYGVPSSA 477
++ R G + V + + I+N Q R V FQFL WP Y +
Sbjct: 1301 ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYR--DTP 1358
Query: 478 ASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEE 537
S FL+++R G + VVHC G GR+GTFC++ I L
Sbjct: 1359 VSKRSFLKLIRQVDKWQEEYNGGEGR-------TVVHCLNGGGRSGTFCAISIVCEMLRH 1411
Query: 538 LGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
T++VF V +R + + +QY FCY+ LE+
Sbjct: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1448
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 189 bits (479), Expect = 8e-48
Identities = 105/292 (35%), Positives = 151/292 (51%), Gaps = 20/292 (6%)
Query: 285 AMTIQELVDYVN---ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQ 341
A+ + +L+ ++ + G EEYE E + + N KNRYG++ D
Sbjct: 892 AIRVADLLQHITQMKCAEGYGFKEEYESFF-EGQSAPWDSAKKDENRMKNRYGNIIAYDH 950
Query: 342 TRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMT 401
+RV+L G T +DYIN +++DGY + N YI TQGP++ T DFW MVW + I+M
Sbjct: 951 SRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMV 1010
Query: 402 TRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVT 461
T E GR KC +YWP D + + VT + E + Y T + + R++
Sbjct: 1011 TNLVEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIR 1067
Query: 462 HFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGR 521
F F WPD+GVP A L+ F+R V +SK P+VVHCSAG GR
Sbjct: 1068 QFHFTGWPDHGVPYHATGLLGFVRQV-------------KSKSPPSAGPLVVHCSAGAGR 1114
Query: 522 TGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE 573
TG F +DI L E G ++++ V +R++R +QT EQY F + AILE
Sbjct: 1115 TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1166
Score = 125 bits (314), Expect = 1e-28
Identities = 89/277 (32%), Positives = 130/277 (46%), Gaps = 19/277 (6%)
Query: 303 IYEEYEDIRRENP-VGTFHCSMS--PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYIN 359
I EE+ + P + CS++ P N EKNR D+ D+ L G + ++YIN
Sbjct: 1199 IKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYIN 1257
Query: 360 ASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLE 419
A+ MD YKQ +A+I TQ PL NT +DFW +V + +VM + + C QYWP
Sbjct: 1258 AALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP-- 1313
Query: 420 KDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQK--RQVTHFQFLSWPDYGVPSSA 477
++ R G + V + + I+N Q R V FQFL WP Y +
Sbjct: 1314 ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYR--DTP 1371
Query: 478 ASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEE 537
S FL+++R G + VVHC G GR+GTFC++ I L
Sbjct: 1372 VSKRSFLKLIRQVDKWQEEYNGGEGR-------TVVHCLNGGGRSGTFCAISIVCEMLRH 1424
Query: 538 LGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574
T++VF V +R + + +QY FCY+ LE+
Sbjct: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1461
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 187 bits (474), Expect = 3e-47
Identities = 103/257 (40%), Positives = 140/257 (54%), Gaps = 19/257 (7%)
Query: 325 PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYR 384
P N++K R + D RV L+ + G TDYINASF+DGY+QK+ +I TQGPL +T
Sbjct: 449 PANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVE 508
Query: 385 DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTV-----TNLGVENM 439
DFW M+WE K IVM T +E + KC QYWP E + G +T+ T ++
Sbjct: 509 DFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTE--GSVTHGEITIEIKNDTLSEAISI 566
Query: 440 NHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMG 499
+ T + +E Q R V F F WP+ G+P+ +ID + V+ QQ
Sbjct: 567 RDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQ------- 619
Query: 500 ARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQ 559
Q PI VHCSAG GRTGTF +L L +++ G L+VFQ V +R QR +Q
Sbjct: 620 -----QTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQ 674
Query: 560 TPEQYYFCYKAILEFAE 576
T EQY FCYK + +F +
Sbjct: 675 TLEQYEFCYKVVQDFID 691
Score = 181 bits (460), Expect = 1e-45
Identities = 113/319 (35%), Positives = 164/319 (51%), Gaps = 31/319 (9%)
Query: 264 IILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSM 323
++L S P+ +P H ++E + +A + EE+ + + GTF +
Sbjct: 99 VMLLSRSPSGPKKYFPIPVEH---LEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELAN 155
Query: 324 SPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTY 383
N EKNRY ++ D +RV L++ G +DYINAS++DGYK+KN +I QGP + T
Sbjct: 156 KEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETV 215
Query: 384 RDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLG--VENMNH 441
DFW MVWEQK IVM T +E KC QYWP + G T N+ VE+
Sbjct: 216 NDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ-------GCWTYGNIRVCVEDCVV 268
Query: 442 YKKTTLEIHNTEE------RQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAV 495
T+ + + R V+ F SWPD+GVP + ++ FL+ V+ +
Sbjct: 269 LVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA 328
Query: 496 SNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRA 555
PIVVHCSAG+GRTGTF +D +A + ++VF+ VSR+R QR
Sbjct: 329 G-------------PIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRP 375
Query: 556 FSIQTPEQYYFCYKAILEF 574
+QT QY F Y+A+LE+
Sbjct: 376 QMVQTDMQYTFIYQALLEY 394
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform
2 [Homo sapiens]
Length = 642
Score = 187 bits (474), Expect = 3e-47
Identities = 103/257 (40%), Positives = 140/257 (54%), Gaps = 19/257 (7%)
Query: 325 PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYR 384
P N++K R + D RV L+ + G TDYINASF+DGY+QK+ +I TQGPL +T
Sbjct: 391 PANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVE 450
Query: 385 DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTV-----TNLGVENM 439
DFW M+WE K IVM T +E + KC QYWP E + G +T+ T ++
Sbjct: 451 DFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTE--GSVTHGEITIEIKNDTLSEAISI 508
Query: 440 NHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMG 499
+ T + +E Q R V F F WP+ G+P+ +ID + V+ QQ
Sbjct: 509 RDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQ------- 561
Query: 500 ARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQ 559
Q PI VHCSAG GRTGTF +L L +++ G L+VFQ V +R QR +Q
Sbjct: 562 -----QTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQ 616
Query: 560 TPEQYYFCYKAILEFAE 576
T EQY FCYK + +F +
Sbjct: 617 TLEQYEFCYKVVQDFID 633
Score = 181 bits (460), Expect = 1e-45
Identities = 113/319 (35%), Positives = 164/319 (51%), Gaps = 31/319 (9%)
Query: 264 IILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSM 323
++L S P+ +P H ++E + +A + EE+ + + GTF +
Sbjct: 41 VMLLSRSPSGPKKYFPIPVEH---LEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELAN 97
Query: 324 SPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTY 383
N EKNRY ++ D +RV L++ G +DYINAS++DGYK+KN +I QGP + T
Sbjct: 98 KEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETV 157
Query: 384 RDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLG--VENMNH 441
DFW MVWEQK IVM T +E KC QYWP + G T N+ VE+
Sbjct: 158 NDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ-------GCWTYGNIRVCVEDCVV 210
Query: 442 YKKTTLEIHNTEE------RQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAV 495
T+ + + R V+ F SWPD+GVP + ++ FL+ V+ +
Sbjct: 211 LVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA 270
Query: 496 SNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRA 555
PIVVHCSAG+GRTGTF +D +A + ++VF+ VSR+R QR
Sbjct: 271 G-------------PIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRP 317
Query: 556 FSIQTPEQYYFCYKAILEF 574
+QT QY F Y+A+LE+
Sbjct: 318 QMVQTDMQYTFIYQALLEY 336
>gi|4506291 protein tyrosine phosphatase, non-receptor type 2
isoform 1 [Homo sapiens]
Length = 415
Score = 187 bits (474), Expect = 3e-47
Identities = 108/272 (39%), Positives = 149/272 (54%), Gaps = 18/272 (6%)
Query: 307 YEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGY 366
Y +IR E+ + P N +NRY DV D +RVKL + + DYINAS +D
Sbjct: 22 YLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQ----NAENDYINASLVDIE 77
Query: 367 KQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRI-- 424
+ + +YI TQGPL NT FWLMVW+QK +VM R E KC QYWP + +
Sbjct: 78 EAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFK 137
Query: 425 RFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFL 484
GF +V L + ++Y L++ N + R ++HF + +WPD+GVP S AS ++FL
Sbjct: 138 ETGF-SVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFL 196
Query: 485 RVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVF 544
VR SL + P V+HCSAGIGR+GTF +D CL +E+ +N+
Sbjct: 197 FKVRESGSLNPDH-----------GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIK 245
Query: 545 QTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE 576
Q + MR R IQTP+Q F Y AI+E A+
Sbjct: 246 QVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAK 277
>gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [Homo
sapiens]
Length = 353
Score = 187 bits (474), Expect = 3e-47
Identities = 108/272 (39%), Positives = 149/272 (54%), Gaps = 18/272 (6%)
Query: 307 YEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGY 366
Y +IR E+ + P N +NRY DV D +RVKL + + DYINAS +D
Sbjct: 22 YLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQ----NAENDYINASLVDIE 77
Query: 367 KQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRI-- 424
+ + +YI TQGPL NT FWLMVW+QK +VM R E KC QYWP + +
Sbjct: 78 EAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFK 137
Query: 425 RFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFL 484
GF +V L + ++Y L++ N + R ++HF + +WPD+GVP S AS ++FL
Sbjct: 138 ETGF-SVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFL 196
Query: 485 RVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVF 544
VR SL + P V+HCSAGIGR+GTF +D CL +E+ +N+
Sbjct: 197 FKVRESGSLNPDH-----------GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIK 245
Query: 545 QTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE 576
Q + MR R IQTP+Q F Y AI+E A+
Sbjct: 246 QVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAK 277
>gi|18104980 protein tyrosine phosphatase, non-receptor type 2
isoform 2 [Homo sapiens]
Length = 387
Score = 187 bits (474), Expect = 3e-47
Identities = 108/272 (39%), Positives = 149/272 (54%), Gaps = 18/272 (6%)
Query: 307 YEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGY 366
Y +IR E+ + P N +NRY DV D +RVKL + + DYINAS +D
Sbjct: 22 YLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQ----NAENDYINASLVDIE 77
Query: 367 KQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRI-- 424
+ + +YI TQGPL NT FWLMVW+QK +VM R E KC QYWP + +
Sbjct: 78 EAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFK 137
Query: 425 RFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFL 484
GF +V L + ++Y L++ N + R ++HF + +WPD+GVP S AS ++FL
Sbjct: 138 ETGF-SVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFL 196
Query: 485 RVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVF 544
VR SL + P V+HCSAGIGR+GTF +D CL +E+ +N+
Sbjct: 197 FKVRESGSLNPDH-----------GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIK 245
Query: 545 QTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE 576
Q + MR R IQTP+Q F Y AI+E A+
Sbjct: 246 QVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAK 277
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,148,632
Number of Sequences: 37866
Number of extensions: 1037956
Number of successful extensions: 2800
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2319
Number of HSP's gapped (non-prelim): 178
length of query: 593
length of database: 18,247,518
effective HSP length: 108
effective length of query: 485
effective length of database: 14,157,990
effective search space: 6866625150
effective search space used: 6866625150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.