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Search of human proteins with 4505835
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505835 polycystin 2 [Homo sapiens]
(968 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505835 polycystin 2 [Homo sapiens] 1944 0.0
gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens] 771 0.0
gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens] 572 e-163
gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens] 219 7e-57
gi|5174633 receptor for egg jelly-like protein precursor [Homo s... 129 1e-29
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 122 2e-27
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 122 2e-27
gi|19923084 polycystin-1L1 [Homo sapiens] 99 3e-20
gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 84 5e-16
gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 84 5e-16
gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens] 84 5e-16
gi|31559825 polycystin 1-like 3 [Homo sapiens] 84 5e-16
gi|5730102 transient receptor potential cation channel, subfamil... 61 6e-09
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 60 1e-08
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 59 2e-08
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 59 2e-08
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 59 2e-08
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 59 2e-08
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 59 2e-08
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1... 59 2e-08
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1... 59 2e-08
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1... 59 2e-08
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1... 59 2e-08
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 58 4e-08
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 57 6e-08
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 57 6e-08
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 57 6e-08
gi|24496763 mucolipin 3 [Homo sapiens] 57 8e-08
gi|194733735 transient receptor potential cation channel, subfam... 57 8e-08
gi|4507687 transient receptor potential cation channel, subfamil... 57 8e-08
>gi|4505835 polycystin 2 [Homo sapiens]
Length = 968
Score = 1944 bits (5035), Expect = 0.0
Identities = 968/968 (100%), Positives = 968/968 (100%)
Query: 1 MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIR 60
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIR
Sbjct: 1 MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIR 60
Query: 61 QAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRP 120
QAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRP
Sbjct: 61 QAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRP 120
Query: 121 GSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPL 180
GSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPL
Sbjct: 121 GSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPL 180
Query: 181 EGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYG 240
EGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYG
Sbjct: 181 EGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYG 240
Query: 241 MMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQ 300
MMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQ
Sbjct: 241 MMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQ 300
Query: 301 TEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP 360
TEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP
Sbjct: 301 TEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP 360
Query: 361 RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR 420
RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR
Sbjct: 361 RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR 420
Query: 421 ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF 480
ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF
Sbjct: 421 ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF 480
Query: 481 CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLE 540
CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLE
Sbjct: 481 CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLE 540
Query: 541 DQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGF 600
DQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGF
Sbjct: 541 DQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGF 600
Query: 601 AIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIY 660
AIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIY
Sbjct: 601 AIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIY 660
Query: 661 FTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKN 720
FTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKN
Sbjct: 661 FTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKN 720
Query: 721 TVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRD 780
TVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRD
Sbjct: 721 TVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRD 780
Query: 781 DLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQ 840
DLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQ
Sbjct: 781 DLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQ 840
Query: 841 VLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEI 900
VLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEI
Sbjct: 841 VLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEI 900
Query: 901 HREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGG 960
HREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGG
Sbjct: 901 HREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGG 960
Query: 961 NGSSNVHV 968
NGSSNVHV
Sbjct: 961 NGSSNVHV 968
>gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens]
Length = 805
Score = 771 bits (1990), Expect = 0.0
Identities = 373/685 (54%), Positives = 509/685 (74%), Gaps = 22/685 (3%)
Query: 193 LVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRM 252
+ +G+RGLWGT L E ++ NRE Y+K+ LREL+ Y++FL+ +C+LTYGM SS+ YYYT++
Sbjct: 73 ICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKV 132
Query: 253 MSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEAD-NRSFIFY 311
MS+LFL TP +F+ +SSM DFW F +G LLD LYW +NQ+ + SFI+Y
Sbjct: 133 MSELFLHTP--SDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYY 190
Query: 312 ENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSE 371
EN+LLGVPR+RQL+VRN SC + +D R++I CYDVYS E++ PFGP NGTAW Y S+
Sbjct: 191 ENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQ 250
Query: 372 KDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNA 431
+L G SHWG + +YSG GYYLDL +R+ +A + +L++ +WLDRGTR FIDFSVYNA
Sbjct: 251 DELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNA 310
Query: 432 NINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEE 491
NINLFCV+RL+VEFPATGG IPSWQ + +KLIRYV+ +DFF+ CE+IFC FIFYYVVEE
Sbjct: 311 NINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEE 370
Query: 492 ILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLL-QFLEDQNTFPNFEH 550
ILE+ IH+L Y S WN LD+V+++LS+VA+G +I+RT V L+ + L+ NT+ +FE
Sbjct: 371 ILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEF 430
Query: 551 LAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLA 610
LA+WQ Q+NN+ AV +FF WIK+FK+I+FN+TM+QLS+T++RCAKD+ GFA+MFFI+F A
Sbjct: 431 LAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFA 490
Query: 611 YAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFF 670
YAQL YL+FGTQV++FSTF +CIFTQFRIILGD ++ I+ ANR+LGP YF T+VFF+FF
Sbjct: 491 YAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFF 550
Query: 671 ILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLR 730
+LLNMFLAIINDTYSEVK +LA QK E++LSDL+++GY+K L++L+L+K V D+ + L+
Sbjct: 551 VLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQ 610
Query: 731 QGGGKLNFDELRQDLKGKGHTD---AEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKERE 787
G ++ F++ L+ GH + E+ A FTK+D+DG++ L E E ++MR DLE+ER
Sbjct: 611 GGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERV 670
Query: 788 DLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVD 847
L+ + L R + S SG + R G SG EEF +L RRV
Sbjct: 671 ALNTEIEKLGRSIVS------------SPQGKSGPEAARAGGWVSG---EEFYMLTRRVL 715
Query: 848 RMEHSIGSIVSKIDAVIVKLEIMER 872
++E + +VS+IDAV KL+++ER
Sbjct: 716 QLETVLEGVVSQIDAVGSKLKMLER 740
>gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens]
Length = 613
Score = 572 bits (1473), Expect = e-163
Identities = 275/548 (50%), Positives = 384/548 (70%), Gaps = 12/548 (2%)
Query: 213 REKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKT 272
+E + + L+EL+ Y +FLI LCILT+GM++ ++YY ++MS LFLDT V E+TNFK+
Sbjct: 21 KEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKS 80
Query: 273 LSSMEDFWKFTEGSLLDGLYWKMQPSNQT--EADNRSFIFYENLLLGVPRIRQLRVRNGS 330
+ S+ DFWKF EG LL+GLYW +NQ N S I+YEN+LLGVPR+RQL+VRN +
Sbjct: 81 IRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNT 140
Query: 331 CSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAG 390
C + + + ECY Y+ ++ED + FG + T W Y S + N HWG + Y G
Sbjct: 141 CKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRY-STSNTNSPWHWGFLGVYRNGG 199
Query: 391 YYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGG 450
Y LS+++ ET + L+ N W+ RGTR FIDFS+YNAN+NLFC++RL+ EFPATGG
Sbjct: 200 YIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGG 259
Query: 451 VIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCL 510
++ SWQF +KL+RYV+ +D+F+A+CEI FC F+F + +E+ +I+ K YF+S WN L
Sbjct: 260 ILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWL 319
Query: 511 DVVIVVLSVVAIGINIYRTSNVEVLL-QFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFV 569
++++++L VA+ N Y + +LL Q L+ + +F LA W I +NNI A+T+FF
Sbjct: 320 ELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFA 379
Query: 570 WIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTF 629
WIK+FKFI+FN+TMSQLS+T+SRC KD+ GFAIMFFIIF AYAQL +LVFG+QVDDFSTF
Sbjct: 380 WIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTF 439
Query: 630 QECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKS 689
Q IF QFRI+LGD NFA I++AN +LGPIYF TF+FF+FF+LLNMFLAIINDTYSEVK+
Sbjct: 440 QNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKA 499
Query: 690 DLA-QQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGK 748
D + ++ + EL +I++ Y L K +LKK D+ ++ G +L + + +
Sbjct: 500 DYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSG-------DLAEQARRE 552
Query: 749 GHTDAEIE 756
G + EI+
Sbjct: 553 GFDENEIQ 560
>gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens]
Length = 2459
Score = 219 bits (559), Expect = 7e-57
Identities = 154/552 (27%), Positives = 258/552 (46%), Gaps = 32/552 (5%)
Query: 158 EDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYL 217
ED P P + G DP + R + L + + T L E+ +
Sbjct: 1893 EDTVAPLPGHLLGPDP-YALFRARRNSSRDVYQPPLTAAIEKMKTTHLKEQKAF------ 1945
Query: 218 KSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSME 277
+++RE++ YL FL +L ++ YG + Y+ R + F F +
Sbjct: 1946 -ALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQHSFT---------RGFSGVLGFR 1995
Query: 278 DFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDL 337
+F+K+ +L+ LY P T+ +++ L+G +IRQ+RV+ SC + Q
Sbjct: 1996 EFFKWANTTLVSNLYGH-PPGFITDGNSK--------LVGSAQIRQVRVQESSCPLAQQP 2046
Query: 338 RDEIKECYDVYSVSSEDRAPFGPR-NGTA---WIYTSEKDLNGSSHWGIIATYSGAGYYL 393
+ + C YS+ +ED A +G N T W Y S+ G WG + Y G GY +
Sbjct: 2047 QAYLNGCRAPYSLDAEDMADYGEGWNATTLSEWQYQSQDQRQGYPIWGKLTVYRGGGYVV 2106
Query: 394 DLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIP 453
L R+ T+ + L N WLD TRA F++ +VYNAN+NLFC+V L +E A G
Sbjct: 2107 PLGTDRQSTSRILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIVTLTLETSALGTFFT 2166
Query: 454 SWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVV 513
Q L+L + + F+ A E+I+ F+ YY+V + + YF S WN L++
Sbjct: 2167 HAALQSLRLYPFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKETWGYFCSKWNLLELA 2226
Query: 514 IVVLSVVAIGINIYRTSNVEVLLQFLED-QNTFPNFEHLAYWQIQFNNIAAVTVFFVWIK 572
I++ S A+ + + R E LQ + + +F A I A V +K
Sbjct: 2227 IILASWSALAVFVKRAVLAERDLQRCRNHREEGISFSETAAADAALGYIIAFLVLLSTVK 2286
Query: 573 LFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQEC 632
L+ + N M+ ++ + R D+ GF I+ + LAY+ + L+FG ++ + T +
Sbjct: 2287 LWHLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLIFGWKLRSYKTLFDA 2346
Query: 633 IFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLA 692
T + LG N+ E+ + + VLG + + FM F++LN+F+++I +SE +
Sbjct: 2347 AETMVSLQLGIFNYEEVLDYSPVLGSFLIGSCIVFMTFVVLNLFISVILVAFSE-EQKYY 2405
Query: 693 QQKAEMELSDLI 704
Q E E+ DL+
Sbjct: 2406 QLSEEGEIVDLL 2417
>gi|5174633 receptor for egg jelly-like protein precursor [Homo
sapiens]
Length = 2253
Score = 129 bits (324), Expect = 1e-29
Identities = 113/511 (22%), Positives = 218/511 (42%), Gaps = 67/511 (13%)
Query: 221 LRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFW 280
L ++T+ +FL +L IL + ++ +YY + + F + T++ +ED +
Sbjct: 1711 LSYILTHFIFLALLLILIVLLRHTDCFYYNQFIRDRF---------SMDLATVTKLEDIY 1761
Query: 281 KFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCS-------I 333
++ LL L+ + P+ E+ ++ +LG+P +RQ+R ++ +
Sbjct: 1762 RWLNSVLLPLLHNDLNPTFLPESSSK--------ILGLPLMRQVRAKSSEKMCLPAEKFV 1813
Query: 334 PQDLRDEIKECYDVYSVSSEDRAPFG--------------------PRNGTAWIYTSEKD 373
+R EI C+ Y + ED + GT W+Y S
Sbjct: 1814 QNSIRREI-HCHPKYGIDPEDTKNYSGFWNEVDKQAIDESTNGFTYKPQGTQWLYYS--- 1869
Query: 374 LNGSSHWGIIATYSGAGY--YLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNA 431
+G++ TY GY Y + R + ++ L+++ WLD T A ++ + +N
Sbjct: 1870 ------YGLLHTYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVLELTTFNP 1923
Query: 432 NINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEE 491
+INLFC + ++ E G V S L + + I FF+ Y VV+E
Sbjct: 1924 DINLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKASAEIYLYVAILIFFLAY-VVDE 1982
Query: 492 ILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQF-LEDQNTFPNFEH 550
I + Y RS +N L+ + + V I + + + +++F L + F F
Sbjct: 1983 GCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSNPEDFIPFHA 2042
Query: 551 LAYWQIQFNNIAAVTV-FFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFII-- 607
++ Q ++I + + F +++ + K + ++R + L G M F++
Sbjct: 2043 VS----QVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSV 2098
Query: 608 -FLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVF 666
F Y YLVFG ++S T F + E NR+LG ++ ++F+
Sbjct: 2099 YFFVYMAFGYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSN-NRILGVLFLSSFML 2157
Query: 667 FMFFILLNMFLAIINDTYSEVKSDLAQQKAE 697
M +L+N+F A+I Y E+K + ++ ++
Sbjct: 2158 VMICVLINLFQAVILSAYEEMKQPVYEEPSD 2188
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 122 bits (305), Expect = 2e-27
Identities = 103/421 (24%), Positives = 178/421 (42%), Gaps = 25/421 (5%)
Query: 206 MEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKT 265
+ + + K L +LR L+ Y+LFL+V + +YG S + + Y R+ S + +
Sbjct: 3655 LAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAY-RLQSAI-----KQEL 3708
Query: 266 EKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLR 325
F ++ E+ W + LL ++ NQ+ + LG PR+RQ+R
Sbjct: 3709 HSRAFLAITRSEELWPWMAHVLLPYVH-----GNQSSPE-----------LGPPRLRQVR 3752
Query: 326 VRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGT-AWIYTSEKDLNGSSHWGIIA 384
++ P R +S S D P NG+ W Y S DL G+ WG A
Sbjct: 3753 LQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAY-SAPDLLGAWSWGSCA 3811
Query: 385 TYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVE 444
Y GY +L + EE+ ++ L+ + WLD +RA F++ + Y+ + L V L +E
Sbjct: 3812 VYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLE 3871
Query: 445 FPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFR 504
FPA G + + +P L R L + F + + V E R + R
Sbjct: 3872 FPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLR 3931
Query: 505 -SFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAA 563
W +V + + + + ++ + F +F+ +A +AA
Sbjct: 3932 LGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAA 3991
Query: 564 VTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQV 623
+F + +K + + F R S T+ R +L G + ++ +AYAQLA L+ + V
Sbjct: 3992 SLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCV 4051
Query: 624 D 624
D
Sbjct: 4052 D 4052
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 122 bits (305), Expect = 2e-27
Identities = 103/421 (24%), Positives = 178/421 (42%), Gaps = 25/421 (5%)
Query: 206 MEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKT 265
+ + + K L +LR L+ Y+LFL+V + +YG S + + Y R+ S + +
Sbjct: 3656 LAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAY-RLQSAI-----KQEL 3709
Query: 266 EKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLR 325
F ++ E+ W + LL ++ NQ+ + LG PR+RQ+R
Sbjct: 3710 HSRAFLAITRSEELWPWMAHVLLPYVH-----GNQSSPE-----------LGPPRLRQVR 3753
Query: 326 VRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGT-AWIYTSEKDLNGSSHWGIIA 384
++ P R +S S D P NG+ W Y S DL G+ WG A
Sbjct: 3754 LQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAY-SAPDLLGAWSWGSCA 3812
Query: 385 TYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVE 444
Y GY +L + EE+ ++ L+ + WLD +RA F++ + Y+ + L V L +E
Sbjct: 3813 VYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLE 3872
Query: 445 FPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFR 504
FPA G + + +P L R L + F + + V E R + R
Sbjct: 3873 FPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLR 3932
Query: 505 -SFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAA 563
W +V + + + + ++ + F +F+ +A +AA
Sbjct: 3933 LGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAA 3992
Query: 564 VTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQV 623
+F + +K + + F R S T+ R +L G + ++ +AYAQLA L+ + V
Sbjct: 3993 SLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCV 4052
Query: 624 D 624
D
Sbjct: 4053 D 4053
>gi|19923084 polycystin-1L1 [Homo sapiens]
Length = 2849
Score = 98.6 bits (244), Expect = 3e-20
Identities = 111/470 (23%), Positives = 192/470 (40%), Gaps = 46/470 (9%)
Query: 182 GQPPRVAWAERLVRGLRG--------LWGTRLMEESSTNREKYLKSVLRELVTYLLFLIV 233
G+ +V A + R LR L GTR RE ++ LR++ +L L++
Sbjct: 2241 GEVEKVLAARQQARHLRWAHPPSKAQLRGTR----QRMRRESRTRAALRDISMDILMLLL 2296
Query: 234 LCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYW 293
L + YG S + Y + + + F ++ + L ++ D+W ++ +LLDGLY
Sbjct: 2297 LLCVIYGRFSQDEYSLNQAIRKEF-----TRNARNCLGGLRNIADWWDWSLTTLLDGLYP 2351
Query: 294 KMQPSNQTEADNRSFIFYENLLLGVPRIRQLRV-RNGSCSIPQDLRDEIKECYDVYSVSS 352
PS + + + L+G IRQL+V C P+ I++ + + S
Sbjct: 2352 GGTPSARVPGAQPGALGGKCYLIGSSVIRQLKVFPRHLCKPPRPFSALIED--SIPTCSP 2409
Query: 353 EDRAPFGPRNGTAWIYTSEKD---LNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASL 409
E P P ++ E LNG G + L L RTR E ++ L
Sbjct: 2410 EVGGPENP-----YLIDPENQNVTLNGPGGCG-----TREDCVLSLGRTRTEAHTALSRL 2459
Query: 410 KKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTF 469
+ ++W+DR TRA + F++YN LF V L VE TG ++PS + + R +
Sbjct: 2460 RASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTGSLVPSSLVESFSIFRSDSAL 2519
Query: 470 DFFLAACEIIFCFFIFYYVVEEILEIRIH-KLHYFRSFWNCLDVVIVVLSVVAIGINIYR 528
+ L +++F ++ ++ + L Y+R N L+ LSVV + + Y
Sbjct: 2520 QYHLMLPQLVFLALSLIHLCVQLYRMMDKGVLSYWRKPRNWLE-----LSVVGVSLTYYA 2574
Query: 529 TSNVEVLL------QFLEDQ-NTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNR 581
S V L QF F + +A W + + + +F +K
Sbjct: 2575 VSGHLVTLAGDVTNQFHRGLCRAFMDLTLMASWNQRARWLRGILLFLFTLKCVYLPGIQN 2634
Query: 582 TMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQE 631
TM+ S+ M +F ++ ++ A + L + V TF +
Sbjct: 2635 TMASCSSMMRHSLPSIFVAGLVGALMLAALSHLHRFLLSMWVLPPGTFTD 2684
>gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1732
Score = 84.3 bits (207), Expect = 5e-16
Identities = 47/221 (21%), Positives = 107/221 (48%), Gaps = 1/221 (0%)
Query: 477 EIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTS-NVEVL 535
++I+ + YY + +++ K +F N LD I+++S + +G+++ S + + +
Sbjct: 1470 QVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1529
Query: 536 LQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAK 595
++ +DQ+ F +F ++ V ++L+ + + + +S T+SR
Sbjct: 1530 ARYRDDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWD 1589
Query: 596 DLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRV 655
++ GF ++ I+ YA L+FG + D+ TF T +++G + E+ + V
Sbjct: 1590 EVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPV 1649
Query: 656 LGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKA 696
LG T V M +++N+F++ I + + + L ++ A
Sbjct: 1650 LGTFLILTSVILMVLVVINLFVSAILMAFGKERKSLKKEAA 1690
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 9/89 (10%)
Query: 211 TNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNF 270
T ++K L + +++ +LFL +L Y +SN +Y L + KT F
Sbjct: 1272 TLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFY---------LHQAIWKTFSHQF 1322
Query: 271 KTLSSMEDFWKFTEGSLLDGLYWKMQPSN 299
+ ++DF+ + LL LY + N
Sbjct: 1323 SEIKLLQDFYPWANHILLPSLYGDYRGKN 1351
>gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1731
Score = 84.3 bits (207), Expect = 5e-16
Identities = 47/221 (21%), Positives = 107/221 (48%), Gaps = 1/221 (0%)
Query: 477 EIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTS-NVEVL 535
++I+ + YY + +++ K +F N LD I+++S + +G+++ S + + +
Sbjct: 1469 QVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1528
Query: 536 LQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAK 595
++ +DQ+ F +F ++ V ++L+ + + + +S T+SR
Sbjct: 1529 ARYRDDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWD 1588
Query: 596 DLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRV 655
++ GF ++ I+ YA L+FG + D+ TF T +++G + E+ + V
Sbjct: 1589 EVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPV 1648
Query: 656 LGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKA 696
LG T V M +++N+F++ I + + + L ++ A
Sbjct: 1649 LGTFLILTSVILMVLVVINLFVSAILMAFGKERKSLKKEAA 1689
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 9/89 (10%)
Query: 211 TNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNF 270
T ++K L + +++ +LFL +L Y +SN +Y L + KT F
Sbjct: 1271 TLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFY---------LHQAIWKTFSHQF 1321
Query: 271 KTLSSMEDFWKFTEGSLLDGLYWKMQPSN 299
+ ++DF+ + LL LY + N
Sbjct: 1322 SEIKLLQDFYPWANHILLPSLYGDYRGKN 1350
>gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens]
Length = 1731
Score = 84.3 bits (207), Expect = 5e-16
Identities = 47/221 (21%), Positives = 107/221 (48%), Gaps = 1/221 (0%)
Query: 477 EIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTS-NVEVL 535
++I+ + YY + +++ K +F N LD I+++S + +G+++ S + + +
Sbjct: 1469 QVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1528
Query: 536 LQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAK 595
++ +DQ+ F +F ++ V ++L+ + + + +S T+SR
Sbjct: 1529 ARYRDDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWD 1588
Query: 596 DLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRV 655
++ GF ++ I+ YA L+FG + D+ TF T +++G + E+ + V
Sbjct: 1589 EVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPV 1648
Query: 656 LGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKA 696
LG T V M +++N+F++ I + + + L ++ A
Sbjct: 1649 LGTFLILTSVILMVLVVINLFVSAILMAFGKERKSLKKEAA 1689
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 9/89 (10%)
Query: 211 TNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNF 270
T ++K L + +++ +LFL +L Y +SN +Y L + KT F
Sbjct: 1271 TLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFY---------LHQAIWKTFSHQF 1321
Query: 271 KTLSSMEDFWKFTEGSLLDGLYWKMQPSN 299
+ ++DF+ + LL LY + N
Sbjct: 1322 SEIKLLQDFYPWANHILLPSLYGDYRGKN 1350
>gi|31559825 polycystin 1-like 3 [Homo sapiens]
Length = 1732
Score = 84.3 bits (207), Expect = 5e-16
Identities = 47/221 (21%), Positives = 107/221 (48%), Gaps = 1/221 (0%)
Query: 477 EIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTS-NVEVL 535
++I+ + YY + +++ K +F N LD I+++S + +G+++ S + + +
Sbjct: 1470 QVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1529
Query: 536 LQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAK 595
++ +DQ+ F +F ++ V ++L+ + + + +S T+SR
Sbjct: 1530 ARYRDDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWD 1589
Query: 596 DLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRV 655
++ GF ++ I+ YA L+FG + D+ TF T +++G + E+ + V
Sbjct: 1590 EVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPV 1649
Query: 656 LGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKA 696
LG T V M +++N+F++ I + + + L ++ A
Sbjct: 1650 LGTFLILTSVILMVLVVINLFVSAILMAFGKERKSLKKEAA 1690
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 9/89 (10%)
Query: 211 TNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNF 270
T ++K L + +++ +LFL +L Y +SN +Y L + KT F
Sbjct: 1272 TLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFY---------LHQAIWKTFSHQF 1322
Query: 271 KTLSSMEDFWKFTEGSLLDGLYWKMQPSN 299
+ ++DF+ + LL LY + N
Sbjct: 1323 SEIKLLQDFYPWANHILLPSLYGDYRGKN 1351
>gi|5730102 transient receptor potential cation channel, subfamily
C, member 6 [Homo sapiens]
Length = 931
Score = 60.8 bits (146), Expect = 6e-09
Identities = 52/221 (23%), Positives = 94/221 (42%), Gaps = 36/221 (16%)
Query: 502 YFRSFWNCLD---VVIVVLSVVAIGINIYRTSNVEVLLQF---LEDQNTFPNFEHLAYW- 554
Y WN LD + I S +A + + S + ++ L+D +++ Y+
Sbjct: 521 YLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYN 580
Query: 555 -----------QIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIM 603
QI + A+ V + ++ + N + L ++ R KD+F F ++
Sbjct: 581 LARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVI 640
Query: 604 FFIIFLAYA-----QLAYLVFGTQVDDFSTFQECIFTQFRIILG---------DINFAEI 649
F ++F+A+ +Y + Q + F+T +E T F I G + N I
Sbjct: 641 FIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFI 700
Query: 650 EEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 690
E VL +Y T M +LLNM +A+IN ++ E++ D
Sbjct: 701 ENIGYVLYGVYNVT----MVIVLLNMLIAMINSSFQEIEDD 737
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 59.7 bits (143), Expect = 1e-08
Identities = 77/371 (20%), Positives = 148/371 (39%), Gaps = 52/371 (14%)
Query: 478 IIFCFFIFYYVVEEILEIRIHKL---HYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEV 534
+ F F+F + + ++++ L YFRS +NC D ++V SV EV
Sbjct: 514 LYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVF------------EV 561
Query: 535 LLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCA 594
+ ++ ++F I+ + + +++FK + ++ L ++
Sbjct: 562 VWAAIKPGSSF--------------GISVLRALRL-LRIFKVTKYWSSLRNLVVSLLNSM 606
Query: 595 KDLFGFAIMFFIIFLAYAQLAYLVFGTQVD--------DFSTFQECIFTQFRIILGD--- 643
K + + F+ + +A L +FG Q + +F TF I T F+I+ G+
Sbjct: 607 KSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWN 666
Query: 644 -INFAEIEEANRV----LGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEM 698
+ + IE V YF F + LLN+FLAI D + + +L + + EM
Sbjct: 667 AVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ-ELTKDEEEM 725
Query: 699 ELSDLIRKGYHKALVKLKLKKNTVDDISESLRQ--GGGKLNFDELRQDLKGKGHTDAEIE 756
E + + KA ++ + +IS + RQ + E R + A E
Sbjct: 726 EEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCE 785
Query: 757 AIFTKYDQDGDQEL--TEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEE 814
A++++ D + T H M+ L++ ++L P+ ++ P + + E
Sbjct: 786 ALYSEMDPEERLRFATTRHLRPDMKTHLDRPLV-VELGRDGARGPVGGKARPEAAEAPEG 844
Query: 815 DDDEDSGHSSR 825
D H R
Sbjct: 845 VDPPRRHHRHR 855
Score = 58.2 bits (139), Expect = 4e-08
Identities = 58/247 (23%), Positives = 97/247 (39%), Gaps = 53/247 (21%)
Query: 469 FDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYR 528
++ L I+F V +I+ + L+YFR WN D V V+ S+
Sbjct: 1499 YELMLKCLNIVFTSMFSMECVLKIIAFGV--LNYFRDAWNVFDFVTVLGSIT-------- 1548
Query: 529 TSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLST 588
++L+ + + N F N L ++ +L K + T+ L
Sbjct: 1549 ----DILVTEIAETNNFINLSFLRLFRAA--------------RLIKLLRQGYTIRILLW 1590
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGT-QVDD---------FSTFQECIFTQFR 638
T + K L ++ ++F YA + VFG +DD F TF + + FR
Sbjct: 1591 TFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFR 1650
Query: 639 IILGDI----------NFAEIEEANRV-----LGPIYFTTFVFFMFFILLNMFLAIINDT 683
G+ N A E+AN YF +F+F F++LN+F+A+I D
Sbjct: 1651 SATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDN 1710
Query: 684 YSEVKSD 690
+ + D
Sbjct: 1711 FEYLTRD 1717
Score = 33.9 bits (76), Expect = 0.76
Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 11/104 (10%)
Query: 483 FIFYYVVEEI-LEIRIHKLHYFRSFWNCLDVVIVVLSVVAIG--------INIYRTSNVE 533
F F V++ I L + +H YFR WN LD ++V ++VA IN ++ V
Sbjct: 1194 FTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVL 1253
Query: 534 VLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFI 577
+L+ L+ P + A + N++ V + LF FI
Sbjct: 1254 RVLRPLKTIKRLPKLK--AVFDCVVNSLKNVLNILIVYMLFMFI 1295
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 59.3 bits (142), Expect = 2e-08
Identities = 78/347 (22%), Positives = 139/347 (40%), Gaps = 51/347 (14%)
Query: 467 TTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINI 526
TT + + C I+ + +E +I K +YF N L+ +I
Sbjct: 764 TTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWII------------ 811
Query: 527 YRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQL 586
Y T + VL F+E HL WQ A+ V+F W+ ++
Sbjct: 812 YTTGIIFVLPLFVEIP------AHLQ-WQC-----GAIAVYFYWMNFLLYLQRFENCGIF 859
Query: 587 STTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINF 646
+ K L ++F + LA+ Y++ Q D FS+ I F ++LGDIN+
Sbjct: 860 IVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQ-DPFSSPLLSIIQTFSMMLGDINY 918
Query: 647 AEI--------EEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVK--SDLAQQKA 696
E E A+ VL +F F+ +L+N+ + + +EV+ + L +
Sbjct: 919 RESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAM 978
Query: 697 EMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNF--------DELRQDLKGK 748
++EL + K ++ +K+T+ + + + GG L E+RQ++
Sbjct: 979 QVELHTSLEKKLPLWFLRKVDQKSTI--VYPNKPRSGGMLFHIFCFLFCTGEIRQEIP-N 1035
Query: 749 GHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEK-----EREDLD 790
E+E + KY L E +H+ ++ ++K E ED D
Sbjct: 1036 ADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDD 1082
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/254 (24%), Positives = 104/254 (40%), Gaps = 50/254 (19%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT----- 1301
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
+ N + + + N+ ++T F F ++L K ++ + L
Sbjct: 1302 ----------EVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1351
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1352 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1411
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1412 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1471
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1472 VAVIMDNFDYLTRD 1485
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 16/58 (27%), Positives = 35/58 (60%), Gaps = 5/58 (8%)
Query: 483 FIFYYVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535
F + +E IL++ +HK + R+++N LD+++V +S+++ GI + V++L
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKIL 997
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 58.9 bits (141), Expect = 2e-08
Identities = 64/261 (24%), Positives = 106/261 (40%), Gaps = 42/261 (16%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I +
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPA 1306
Query: 531 NVEVLLQFLEDQNTFPNFEHL-------AYWQIQFNNIAAVTVF--FVWIKLFKFINFNR 581
+ + P L + + N+ ++T F F ++L K ++
Sbjct: 1307 EHTQCSPSMGPSCSHPPLAVLTAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLSRGE 1366
Query: 582 TMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQE 631
+ L T + + L A++ ++F YA + VFG T++ ++F TF +
Sbjct: 1367 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQ 1426
Query: 632 CIFTQFRIILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMF 669
+ FR G DI A E E +N G YF +F
Sbjct: 1427 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1486
Query: 670 FILLNMFLAIINDTYSEVKSD 690
F+++N+F+A+I D + + D
Sbjct: 1487 FLIINLFVAVIMDNFDYLTRD 1507
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 18/66 (27%), Positives = 39/66 (59%), Gaps = 8/66 (12%)
Query: 478 IIFCFFIFY---YVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRT 529
I+F F I + + +E L++ +HK + R+++N LD+++V +S+++ GI
Sbjct: 932 ILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAI 991
Query: 530 SNVEVL 535
+ V++L
Sbjct: 992 NVVKIL 997
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/254 (24%), Positives = 104/254 (40%), Gaps = 50/254 (19%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT----- 1301
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
+ N + + + N+ ++T F F ++L K ++ + L
Sbjct: 1302 ----------EVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1351
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1352 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1411
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1412 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1471
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1472 VAVIMDNFDYLTRD 1485
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 18/66 (27%), Positives = 39/66 (59%), Gaps = 8/66 (12%)
Query: 478 IIFCFFIFY---YVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRT 529
I+F F I + + +E L++ +HK + R+++N LD+++V +S+++ GI
Sbjct: 932 ILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAI 991
Query: 530 SNVEVL 535
+ V++L
Sbjct: 992 NVVKIL 997
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/254 (24%), Positives = 104/254 (40%), Gaps = 50/254 (19%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT----- 1301
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
+ N + + + N+ ++T F F ++L K ++ + L
Sbjct: 1302 ----------EVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1351
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1352 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1411
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1412 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1471
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1472 VAVIMDNFDYLTRD 1485
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 16/58 (27%), Positives = 35/58 (60%), Gaps = 5/58 (8%)
Query: 483 FIFYYVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535
F + +E IL++ +HK + R+++N LD+++V +S+++ GI + V++L
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKIL 997
>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 14 [Homo sapiens]
Length = 2138
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/254 (24%), Positives = 104/254 (40%), Gaps = 50/254 (19%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT----- 1301
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
+ N + + + N+ ++T F F ++L K ++ + L
Sbjct: 1302 ----------EVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1351
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1352 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1411
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1412 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1471
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1472 VAVIMDNFDYLTRD 1485
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 16/58 (27%), Positives = 35/58 (60%), Gaps = 5/58 (8%)
Query: 483 FIFYYVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535
F + +E IL++ +HK + R+++N LD+++V +S+++ GI + V++L
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKIL 997
>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 9 [Homo sapiens]
Length = 2157
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/254 (24%), Positives = 104/254 (40%), Gaps = 50/254 (19%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT----- 1301
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
+ N + + + N+ ++T F F ++L K ++ + L
Sbjct: 1302 ----------EVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1351
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1352 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1411
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1412 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1471
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1472 VAVIMDNFDYLTRD 1485
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 16/58 (27%), Positives = 35/58 (60%), Gaps = 5/58 (8%)
Query: 483 FIFYYVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535
F + +E IL++ +HK + R+++N LD+++V +S+++ GI + V++L
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKIL 997
>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 8 [Homo sapiens]
Length = 2157
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/254 (24%), Positives = 104/254 (40%), Gaps = 50/254 (19%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT----- 1301
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
+ N + + + N+ ++T F F ++L K ++ + L
Sbjct: 1302 ----------EVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1351
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1352 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1411
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1412 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1471
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1472 VAVIMDNFDYLTRD 1485
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 18/66 (27%), Positives = 39/66 (59%), Gaps = 8/66 (12%)
Query: 478 IIFCFFIFY---YVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRT 529
I+F F I + + +E L++ +HK + R+++N LD+++V +S+++ GI
Sbjct: 932 ILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAI 991
Query: 530 SNVEVL 535
+ V++L
Sbjct: 992 NVVKIL 997
>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 6 [Homo sapiens]
Length = 2158
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/254 (24%), Positives = 104/254 (40%), Gaps = 50/254 (19%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I
Sbjct: 1267 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT----- 1321
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
+ N + + + N+ ++T F F ++L K ++ + L
Sbjct: 1322 ----------EVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1371
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1372 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1431
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1432 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1491
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1492 VAVIMDNFDYLTRD 1505
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 16/58 (27%), Positives = 35/58 (60%), Gaps = 5/58 (8%)
Query: 483 FIFYYVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535
F + +E IL++ +HK + R+++N LD+++V +S+++ GI + V++L
Sbjct: 960 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKIL 1017
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 58.2 bits (139), Expect = 4e-08
Identities = 61/252 (24%), Positives = 97/252 (38%), Gaps = 59/252 (23%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITENAEE 1306
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTM 590
N + + F F ++L K ++ + L T
Sbjct: 1307 NSRISITFFR--------------------------LFRVMRLVKLLSRGEGIRTLLWTF 1340
Query: 591 SRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFRII 640
+ + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1341 IKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCA 1400
Query: 641 LG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMFLA 678
G DI A E E +N G YF +F F+++N+F+A
Sbjct: 1401 TGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVA 1460
Query: 679 IINDTYSEVKSD 690
+I D + + D
Sbjct: 1461 VIMDNFDYLTRD 1472
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 18/66 (27%), Positives = 39/66 (59%), Gaps = 8/66 (12%)
Query: 478 IIFCFFIFY---YVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRT 529
I+F F I + + +E L++ +HK + R+++N LD+++V +S+++ GI
Sbjct: 932 ILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAI 991
Query: 530 SNVEVL 535
+ V++L
Sbjct: 992 NVVKIL 997
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 57.4 bits (137), Expect = 6e-08
Identities = 64/254 (25%), Positives = 102/254 (40%), Gaps = 61/254 (24%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I +
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT--EVN 1304
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
N E N+ ++T F F ++L K ++ + L
Sbjct: 1305 NAEE------------------------NSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1340
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1341 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1400
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1401 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1460
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1461 VAVIMDNFDYLTRD 1474
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 16/58 (27%), Positives = 35/58 (60%), Gaps = 5/58 (8%)
Query: 483 FIFYYVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535
F + +E IL++ +HK + R+++N LD+++V +S+++ GI + V++L
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKIL 997
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 57.4 bits (137), Expect = 6e-08
Identities = 64/254 (25%), Positives = 102/254 (40%), Gaps = 61/254 (24%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I +
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT--EVN 1304
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
N E N+ ++T F F ++L K ++ + L
Sbjct: 1305 NAEE------------------------NSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1340
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1341 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1400
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1401 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1460
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1461 VAVIMDNFDYLTRD 1474
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 16/58 (27%), Positives = 35/58 (60%), Gaps = 5/58 (8%)
Query: 483 FIFYYVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535
F + +E IL++ +HK + R+++N LD+++V +S+++ GI + V++L
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKIL 997
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 57.4 bits (137), Expect = 6e-08
Identities = 64/254 (25%), Positives = 102/254 (40%), Gaps = 61/254 (24%)
Query: 472 FLAACEIIFCFFIFYYVVEEILEIRIHK-LHYFRSFWNCLDVVIVVLSVVAIGINIYRTS 530
F A I+ F + VE IL++ K HYF WN D +IVV S+V I I +
Sbjct: 1247 FKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAIT--EVN 1304
Query: 531 NVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVF--FVWIKLFKFINFNRTMSQLST 588
N E N+ ++T F F ++L K ++ + L
Sbjct: 1305 NAEE------------------------NSRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1340
Query: 589 TMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-------TQV---DDFSTFQECIFTQFR 638
T + + L A++ ++F YA + VFG T++ ++F TF + + FR
Sbjct: 1341 TFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1400
Query: 639 IILG----DINFA---------EIEEANRVLGP---------IYFTTFVFFMFFILLNMF 676
G DI A E E +N G YF +F F+++N+F
Sbjct: 1401 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1460
Query: 677 LAIINDTYSEVKSD 690
+A+I D + + D
Sbjct: 1461 VAVIMDNFDYLTRD 1474
Score = 51.2 bits (121), Expect = 5e-06
Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 50/271 (18%)
Query: 571 IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG---------T 621
+++FK + ++S L ++ + + ++ F+ + ++ L +FG T
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 622 QVDDFSTFQECIFTQFRIILG-DINFAEIEEANRVLGP--------IYFTTFVFFMFFIL 672
+ F F + + T F+I+ G D N + GP IYF +IL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 673 LNMFLAIINDTYSEVKSDLAQQKAEME---------------LSDLIRK---GYHKALVK 714
LN+FLAI D ++ +S + QK E E +L+ K G K K
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE-EK 803
Query: 715 LKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHE 774
++LK T D S K+N D+L+ + + E ++ + + G+++ E E
Sbjct: 804 IELKSITADGESPP----ATKINMDDLQPN-------ENEDKSPYPNPETTGEED--EEE 850
Query: 775 HQQMRDDLEKEREDLDLDHSSLPRPMSSRSF 805
+ + +L L ++P P +S F
Sbjct: 851 PEMPVGPRPRPLSELHLKEKAVPMPEASAFF 881
Score = 30.8 bits (68), Expect = 6.4
Identities = 18/66 (27%), Positives = 39/66 (59%), Gaps = 8/66 (12%)
Query: 478 IIFCFFIFY---YVVEEILEIR-----IHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRT 529
I+F F I + + +E L++ +HK + R+++N LD+++V +S+++ GI
Sbjct: 932 ILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAI 991
Query: 530 SNVEVL 535
+ V++L
Sbjct: 992 NVVKIL 997
>gi|24496763 mucolipin 3 [Homo sapiens]
Length = 553
Score = 57.0 bits (136), Expect = 8e-08
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 561 IAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG 620
+ + VW+ + +++ F + L T+ ++ F +I+L Y ++V G
Sbjct: 376 LLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLG 435
Query: 621 TQVDDFSTF---QECIFTQFRIILGDINFAEIEEANR------VLGPIYFTTFVFFMFFI 671
D F + EC+F+ +I GD FA + + + IY +F+ ++
Sbjct: 436 PYHDKFRSLNMVSECLFS---LINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYM 492
Query: 672 LLNMFLAIINDTYSEVKSDLAQQKAEMELSDLI 704
+L++F+A+I DTY +K E EL I
Sbjct: 493 ILSLFIALITDTYETIKQYQQDGFPETELRTFI 525
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 57.0 bits (136), Expect = 8e-08
Identities = 52/221 (23%), Positives = 90/221 (40%), Gaps = 36/221 (16%)
Query: 502 YFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQF---------LEDQNTFPNFEHLA 552
Y WN LD ++ + + A Q+ L + P ++
Sbjct: 537 YILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFT 596
Query: 553 Y----W-----QIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIM 603
Y W QI + A+ V + ++ + N + L ++ R KD+F F ++
Sbjct: 597 YARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVL 656
Query: 604 FFIIFLAYAQLAYLVF----GTQVD-DFSTFQECIFTQFRIILG---------DINFAEI 649
F ++F A+ ++++ G +V+ F+T +E T F I G + I
Sbjct: 657 FIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFI 716
Query: 650 EEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 690
E VL IY T M +LLNM +A+IN +Y E++ D
Sbjct: 717 ENIGYVLYGIYNVT----MVVVLLNMLIAMINSSYQEIEDD 753
>gi|4507687 transient receptor potential cation channel, subfamily
C, member 3 isoform b [Homo sapiens]
Length = 848
Score = 57.0 bits (136), Expect = 8e-08
Identities = 52/221 (23%), Positives = 90/221 (40%), Gaps = 36/221 (16%)
Query: 502 YFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQF---------LEDQNTFPNFEHLA 552
Y WN LD ++ + + A Q+ L + P ++
Sbjct: 464 YILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFT 523
Query: 553 Y----W-----QIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIM 603
Y W QI + A+ V + ++ + N + L ++ R KD+F F ++
Sbjct: 524 YARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVL 583
Query: 604 FFIIFLAYAQLAYLVF----GTQVD-DFSTFQECIFTQFRIILG---------DINFAEI 649
F ++F A+ ++++ G +V+ F+T +E T F I G + I
Sbjct: 584 FIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFI 643
Query: 650 EEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 690
E VL IY T M +LLNM +A+IN +Y E++ D
Sbjct: 644 ENIGYVLYGIYNVT----MVVVLLNMLIAMINSSYQEIEDD 680
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,202,561
Number of Sequences: 37866
Number of extensions: 1936171
Number of successful extensions: 15181
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 348
Number of HSP's that attempted gapping in prelim test: 13412
Number of HSP's gapped (non-prelim): 1848
length of query: 968
length of database: 18,247,518
effective HSP length: 112
effective length of query: 856
effective length of database: 14,006,526
effective search space: 11989586256
effective search space used: 11989586256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.