Search of human proteins with 4505697

Search of human proteins with 4505697

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505697 pendrin [Homo sapiens]
         (780 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505697 pendrin [Homo sapiens]                                    1512   0.0  
gi|4557535 solute carrier family 26, member 3 [Homo sapiens]          683   0.0  
gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo s...   550   e-156
gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo s...   550   e-156
gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo s...   547   e-155
gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo s...   546   e-155
gi|39752683 prestin isoform a [Homo sapiens]                          538   e-152
gi|45827800 prestin isoform b [Homo sapiens]                          523   e-148
gi|16418413 solute carrier family 26, member 9 isoform a [Homo s...   459   e-129
gi|217272867 solute carrier family 26, member 9 isoform b [Homo ...   459   e-129
gi|100913030 solute carrier family 26 member 2 [Homo sapiens]         444   e-124
gi|45827802 prestin isoform c [Homo sapiens]                          438   e-122
gi|47131207 solute carrier family 26, member 1 isoform a [Homo s...   404   e-112
gi|20336272 solute carrier family 26, member 1 isoform a [Homo s...   404   e-112
gi|20336282 solute carrier family 26, member 7 isoform b [Homo s...   323   4e-88
gi|16306483 solute carrier family 26, member 7 isoform a [Homo s...   323   5e-88
gi|16418457 solute carrier family 26, member 8 isoform a [Homo s...   292   9e-79
gi|65506789 solute carrier family 26, member 10 [Homo sapiens]        276   5e-74
gi|45827804 prestin isoform d [Homo sapiens]                          271   1e-72
gi|217272870 solute carrier family 26, member 9 isoform c [Homo ...   216   5e-56
gi|85540447 solute carrier family 26, member 11 [Homo sapiens]        177   4e-44
gi|20336285 solute carrier family 26, member 8 isoform b [Homo s...   163   7e-40
gi|20336274 solute carrier family 26, member 1 isoform b [Homo s...   114   3e-25
gi|7706575 transmembrane 7 superfamily member 3 [Homo sapiens]         32   3.0  
gi|153945707 endothelin converting enzyme 2 isoform C [Homo sapi...    30   8.6  
gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapi...    30   8.6  
gi|91982772 mucin 17 [Homo sapiens]                                    30   8.6  

>gi|4505697 pendrin [Homo sapiens]
          Length = 780

 Score = 1512 bits (3915), Expect = 0.0
 Identities = 780/780 (100%), Positives = 780/780 (100%)

Query: 1   MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKR 60
           MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKR
Sbjct: 1   MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKR 60

Query: 61  AFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSA 120
           AFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSA
Sbjct: 61  AFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSA 120

Query: 121 FFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAA 180
           FFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAA
Sbjct: 121 FFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAA 180

Query: 181 RDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVL 240
           RDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVL
Sbjct: 181 RDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVL 240

Query: 241 NVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPI 300
           NVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPI
Sbjct: 241 NVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPI 300

Query: 301 PIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVA 360
           PIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVA
Sbjct: 301 PIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVA 360

Query: 361 YAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKT 420
           YAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKT
Sbjct: 361 YAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKT 420

Query: 421 QVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAV 480
           QVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAV
Sbjct: 421 QVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAV 480

Query: 481 IWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIE 540
           IWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIE
Sbjct: 481 IWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIE 540

Query: 541 EPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRAT 600
           EPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRAT
Sbjct: 541 EPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRAT 600

Query: 601 KNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVL 660
           KNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVL
Sbjct: 601 KNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVL 660

Query: 661 DCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFL 720
           DCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFL
Sbjct: 661 DCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFL 720

Query: 721 TVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS 780
           TVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
Sbjct: 721 TVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS 780


>gi|4557535 solute carrier family 26, member 3 [Homo sapiens]
          Length = 764

 Score =  683 bits (1763), Expect = 0.0
 Identities = 347/716 (48%), Positives = 478/716 (66%), Gaps = 10/716 (1%)

Query: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79
           Y+V+RPVYS  AF++ H++  +  KT  + L  CCSCS ++A  ++ +L PI  WLP YR
Sbjct: 9   YIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYR 68

Query: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139
           +KEWLLSD++SG+STG+VA LQG+A+ALL  +P  YGLY++FFP + Y  FGTSRHISVG
Sbjct: 69  LKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVG 128

Query: 140 PFPVVSLMVG----SVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLL 195
           PFP++S+MVG      V    PD +           N++++D    +  RV  A+++T+L
Sbjct: 129 PFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDD---ERVRVAAAASVTVL 185

Query: 196 VGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIY 255
            GIIQL FG L+IGF+V YL++ L+ GFTTAAA  VLVSQLK +  ++  ++   +SI  
Sbjct: 186 SGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFK 245

Query: 256 TLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISY 315
            L  +F  I  TN+AD    L+ ++V   VKE+N RF+ K+PVPIPIE I+T+IA  +SY
Sbjct: 246 VLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSY 305

Query: 316 GANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKY 375
           G + +  +   +V  +  GF PP  P V  F   +   F IA+VA+A+A SV  VY+ KY
Sbjct: 306 GCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKY 365

Query: 376 DYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAI 435
           DY +DGNQE IA G+ NI  G F  F  +TALSR+AVQESTGGKTQ+AG+I A IV+I +
Sbjct: 366 DYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVV 425

Query: 436 LALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLD 495
           LA+G LL PLQKSVLAA+ + NLKGM MQ  +I RLWR++K D +IW+ T I +I+LGL 
Sbjct: 426 LAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLG 485

Query: 496 LGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIF 555
           LGL A + F LLT+V R QFP  + L +I  T+IYK+ K+Y ++ EP+GVKI R  SPI+
Sbjct: 486 LGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIY 545

Query: 556 YGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAF 615
           + N+  F++ +   VGF  +R+  KR KALRKI+KL K G L+ T  G I   V T    
Sbjct: 546 FANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFIC-TVDTIKDS 604

Query: 616 EPDEDIEDLEELDIP--TKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGV 673
           + + D   +E LD P  T ++   +DWN +LP+ + VPK+ +HSL+LD  A+SFLDV  V
Sbjct: 605 DEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSV 664

Query: 674 RSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYL 729
           R L+ I++EF RI V+VY     D  IEKL +  FFD  ++   FFLT+HDA+L++
Sbjct: 665 RGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHI 720


>gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo
           sapiens]
          Length = 738

 Score =  550 bits (1416), Expect = e-156
 Identities = 284/691 (41%), Positives = 438/691 (63%), Gaps = 29/691 (4%)

Query: 56  CSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGY 115
           CSR RA+ +L   +P+L WLP+Y V++WLL D++SG+S  ++   QG+AYALLA +P  +
Sbjct: 41  CSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVF 100

Query: 116 GLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTM 175
           GLYS+F+P+  YF+FGTSRHISVG F V+S+MVGSV  S+AP             LN +M
Sbjct: 101 GLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ-----------ALNDSM 149

Query: 176 IDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQ 235
           I+  ARD ARV +AS L++LVG+ Q+  G +  GF+V YL++PLV G+TTAAA QV VSQ
Sbjct: 150 INETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQ 209

Query: 236 LKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHK 295
           LK V  +   +++G LS+IYT++E+   +  + +       +  VV + VK LND+ + +
Sbjct: 210 LKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQ 269

Query: 296 IPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS 355
           +P+PIP E++  I AT ISYG  L+  +   +V +IP G +PP  P   LFS+++ ++F+
Sbjct: 270 LPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFT 329

Query: 356 IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQES 415
           IAVV +AIA+S+GK++A ++ Y +D NQE +A G+SN+  G F CF  + ++SR+ VQES
Sbjct: 330 IAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQES 389

Query: 416 TGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQN 475
           TGG +QVAG IS+  +++ I+ LG+L   L K+VLAA++I NLKGM  QL D+  LW+ N
Sbjct: 390 TGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKAN 449

Query: 476 KIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKN 535
           + D +IW+ T   +I+L LDLGL+  +IF LL VV+R Q P ++ LG +P TDIY+    
Sbjct: 450 RADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAE 509

Query: 536 YKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALR-----KIQK 590
           Y   +E +GVK+ R S+ +++ N + +   +K   G D   + +++ K L+     K+++
Sbjct: 510 YSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQ 569

Query: 591 LIKSGQLR----ATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPV 646
           L K  +LR    + K   +S  V+T+       ++ED + + + + +       N +   
Sbjct: 570 LQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDS 629

Query: 647 K---------VNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQD 697
           K         + +P+   HSL+LD GA+SF+D V ++SL+ I  +F+ I+V VY A+   
Sbjct: 630 KAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHS 689

Query: 698 YVIEKLEQCGFFDDNIRKDTFFLTVHDAILY 728
            V+ +LE   FFD +I K   F +VHDA+ +
Sbjct: 690 PVVSQLEAGHFFDASITKKHLFASVHDAVTF 720


>gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo
           sapiens]
          Length = 759

 Score =  550 bits (1416), Expect = e-156
 Identities = 284/691 (41%), Positives = 438/691 (63%), Gaps = 29/691 (4%)

Query: 56  CSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGY 115
           CSR RA+ +L   +P+L WLP+Y V++WLL D++SG+S  ++   QG+AYALLA +P  +
Sbjct: 62  CSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVF 121

Query: 116 GLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTM 175
           GLYS+F+P+  YF+FGTSRHISVG F V+S+MVGSV  S+AP             LN +M
Sbjct: 122 GLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ-----------ALNDSM 170

Query: 176 IDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQ 235
           I+  ARD ARV +AS L++LVG+ Q+  G +  GF+V YL++PLV G+TTAAA QV VSQ
Sbjct: 171 INETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQ 230

Query: 236 LKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHK 295
           LK V  +   +++G LS+IYT++E+   +  + +       +  VV + VK LND+ + +
Sbjct: 231 LKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQ 290

Query: 296 IPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS 355
           +P+PIP E++  I AT ISYG  L+  +   +V +IP G +PP  P   LFS+++ ++F+
Sbjct: 291 LPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFT 350

Query: 356 IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQES 415
           IAVV +AIA+S+GK++A ++ Y +D NQE +A G+SN+  G F CF  + ++SR+ VQES
Sbjct: 351 IAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQES 410

Query: 416 TGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQN 475
           TGG +QVAG IS+  +++ I+ LG+L   L K+VLAA++I NLKGM  QL D+  LW+ N
Sbjct: 411 TGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKAN 470

Query: 476 KIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKN 535
           + D +IW+ T   +I+L LDLGL+  +IF LL VV+R Q P ++ LG +P TDIY+    
Sbjct: 471 RADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAE 530

Query: 536 YKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALR-----KIQK 590
           Y   +E +GVK+ R S+ +++ N + +   +K   G D   + +++ K L+     K+++
Sbjct: 531 YSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQ 590

Query: 591 LIKSGQLR----ATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPV 646
           L K  +LR    + K   +S  V+T+       ++ED + + + + +       N +   
Sbjct: 591 LQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDS 650

Query: 647 K---------VNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQD 697
           K         + +P+   HSL+LD GA+SF+D V ++SL+ I  +F+ I+V VY A+   
Sbjct: 651 KAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHS 710

Query: 698 YVIEKLEQCGFFDDNIRKDTFFLTVHDAILY 728
            V+ +LE   FFD +I K   F +VHDA+ +
Sbjct: 711 PVVSQLEAGHFFDASITKKHLFASVHDAVTF 741


>gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo
           sapiens]
          Length = 740

 Score =  547 bits (1410), Expect = e-155
 Identities = 283/678 (41%), Positives = 433/678 (63%), Gaps = 22/678 (3%)

Query: 56  CSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGY 115
           CSR RA+ +L   +P+L WLP+Y V++WLL D++SG+S  ++   QG+AYALLA +P  +
Sbjct: 62  CSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVF 121

Query: 116 GLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTM 175
           GLYS+F+P+  YF+FGTSRHISVG F V+S+MVGSV  S+AP             LN +M
Sbjct: 122 GLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ-----------ALNDSM 170

Query: 176 IDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQ 235
           I+  ARD ARV +AS L++LVG+ Q+  G +  GF+V YL++PLV G+TTAAA QV VSQ
Sbjct: 171 INETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQ 230

Query: 236 LKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHK 295
           LK V  +   +++G LS+IYT++E+   +  + +       +  VV + VK LND+ + +
Sbjct: 231 LKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQ 290

Query: 296 IPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS 355
           +P+PIP E++  I AT ISYG  L+  +   +V +IP G +PP  P   LFS+++ ++F+
Sbjct: 291 LPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFT 350

Query: 356 IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQES 415
           IAVV +AIA+S+GK++A ++ Y +D NQE +A G+SN+  G F CF  + ++SR+ VQES
Sbjct: 351 IAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQES 410

Query: 416 TGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQN 475
           TGG +QVAG IS+  +++ I+ LG+L   L K+VLAA++I NLKGM  QL D+  LW+ N
Sbjct: 411 TGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKAN 470

Query: 476 KIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKN 535
           + D +IW+ T   +I+L LDLGL+  +IF LL VV+R Q P ++ LG +P TDIY+    
Sbjct: 471 RADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAE 530

Query: 536 YKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALR-----KIQK 590
           Y   +E +GVK+ R S+ +++ N + +   +K   G D   + +++ K L+     K+++
Sbjct: 531 YSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQ 590

Query: 591 LIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNV 650
           L K  +LR     ++S  ++       D+    +E+     +E     D  S L   + +
Sbjct: 591 LQKEEKLRKQAGPLLSACLAPQQVSSGDK----MEDATANGQEDSKAPD-GSTLKA-LGL 644

Query: 651 PKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFD 710
           P+   HSL+LD GA+SF+D V ++SL+ I  +F+ I+V VY A+    V+ +LE   FFD
Sbjct: 645 PQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFD 704

Query: 711 DNIRKDTFFLTVHDAILY 728
            +I K   F +VHDA+ +
Sbjct: 705 ASITKKHLFASVHDAVTF 722


>gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo
           sapiens]
          Length = 758

 Score =  546 bits (1408), Expect = e-155
 Identities = 285/690 (41%), Positives = 439/690 (63%), Gaps = 28/690 (4%)

Query: 56  CSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGY 115
           CSR RA+ +L   +P+L WLP+Y V++WLL D++SG+S  ++   QG+AYALLA +P  +
Sbjct: 62  CSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVF 121

Query: 116 GLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTM 175
           GLYS+F+P+  YF+FGTSRHISVG F V+S+MVGSV  S+AP             LN +M
Sbjct: 122 GLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ-----------ALNDSM 170

Query: 176 IDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQ 235
           I+  ARD ARV +AS L++LVG+ Q+  G +  GF+V YL++PLV G+TTAAA QV VSQ
Sbjct: 171 INETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQ 230

Query: 236 LKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHK 295
           LK V  +   +++G LS+IYT++E+   +  + +       +  VV + VK LND+ + +
Sbjct: 231 LKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQ 290

Query: 296 IPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS 355
           +P+PIP E++  I AT ISYG  L+  +   +V +IP G +PP  P   LFS+++ ++F+
Sbjct: 291 LPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFT 350

Query: 356 IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQES 415
           IAVV +AIA+S+GK++A ++ Y +D NQE +A G+SN+  G F CF  + ++SR+ VQES
Sbjct: 351 IAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQES 410

Query: 416 TGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQN 475
           TGG +QVAG IS+  +++ I+ LG+L   L K+VLAA++I NLKGM  QL D+  LW+ N
Sbjct: 411 TGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKAN 470

Query: 476 KIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKN 535
           + D +IW+ T   +I+L LDLGL+  +IF LL VV+R Q P ++ LG +P TDIY+    
Sbjct: 471 RADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAE 530

Query: 536 YKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALR-----KIQK 590
           Y   +E +GVK+ R S+ +++ N + +   +K   G D   + +++ K L+     K+++
Sbjct: 531 YSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQ 590

Query: 591 LIKSGQLR----ATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIE---IQVDWNSE 643
           L K  +LR    + K   +S  V+T+       ++ED + +     ++E        +S+
Sbjct: 591 LQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSK 650

Query: 644 LP-----VKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDY 698
            P       + +P+   HSL+LD GA+SF+D V ++SL+ I  +F+ I+V VY A+    
Sbjct: 651 APDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSP 710

Query: 699 VIEKLEQCGFFDDNIRKDTFFLTVHDAILY 728
           V+ +LE   FFD +I K   F +VHDA+ +
Sbjct: 711 VVSQLEAGHFFDASITKKHLFASVHDAVTF 740


>gi|39752683 prestin isoform a [Homo sapiens]
          Length = 744

 Score =  538 bits (1385), Expect = e-152
 Identities = 277/723 (38%), Positives = 437/723 (60%), Gaps = 14/723 (1%)

Query: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79
           Y V RP++S    Q++   + +   ++ + L +  +C+ K+   ++   +PI +WLP Y+
Sbjct: 16  YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYK 75

Query: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139
            KE++L D++SG+STG++   QG+A+A+LAAVP  +GLYS+F+P++ Y   GTSRHIS+G
Sbjct: 76  FKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIG 135

Query: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199
           PF V+SLM+G V + + PD+  +    N T        T ARD  RV +A ++TLL GII
Sbjct: 136 PFAVISLMIGGVAVRLVPDDIVIPGGVNATN------GTEARDALRVKVAMSVTLLSGII 189

Query: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259
           Q   G  + GF+  YL +PLV GFTTAAA  V  S LK +  V TK Y+G+ S++Y+ V 
Sbjct: 190 QFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVA 249

Query: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319
           + QN+ + N+     GL+   + +  KE N+RF+ K+P PIP+E    ++ T IS G NL
Sbjct: 250 VLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNL 309

Query: 320 EKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTI 379
           +++YN  +V ++P G LPP  P  SLF  +   + +IA+V +++ +S+ K  A K+ Y +
Sbjct: 310 KESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQV 369

Query: 380 DGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439
           DGNQE IA G+ N     F  F  + +LSR+ VQE TGGKTQ+AG +++ ++++ ILA G
Sbjct: 370 DGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATG 429

Query: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLL 499
            L E L ++VL+A+VI NLKGMFMQ  D+P  WR +KI+  IW+ T + S+ LGLD GL+
Sbjct: 430 FLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLI 489

Query: 500 AGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNV 559
             +I  LLTV+ R Q PS+  LG +P TD+Y     Y+ ++E  G+KI + ++PI+Y N 
Sbjct: 490 TAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANS 549

Query: 560 DGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDA-VSTNNAFEPD 618
           D +   +K   G +   +   R KA+RK  K + +  + A    + +DA V   +A +P+
Sbjct: 550 DLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANM-ANATVVKADAEVDGEDATKPE 608

Query: 619 EDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRV 678
           E     E+ ++    I I+  +  E+  +   P   +H+++LD   ++F+D VGV++L  
Sbjct: 609 E-----EDGEVKYPPIVIKSTFPEEMQ-RFMPPGDNVHTVILDFTQVNFIDSVGVKTLAG 662

Query: 679 IVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEG 738
           IVKE+  + + VY A     V+  L +  FF++    +  F ++HDA+L  Q +    E 
Sbjct: 663 IVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQ 722

Query: 739 QGS 741
           + S
Sbjct: 723 EAS 725


>gi|45827800 prestin isoform b [Homo sapiens]
          Length = 685

 Score =  523 bits (1346), Expect = e-148
 Identities = 265/681 (38%), Positives = 417/681 (61%), Gaps = 14/681 (2%)

Query: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79
           Y V RP++S    Q++   + +   ++ + L +  +C+ K+   ++   +PI +WLP Y+
Sbjct: 16  YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYK 75

Query: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139
            KE++L D++SG+STG++   QG+A+A+LAAVP  +GLYS+F+P++ Y   GTSRHIS+G
Sbjct: 76  FKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIG 135

Query: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199
           PF V+SLM+G V + + PD+  +    N T        T ARD  RV +A ++TLL GII
Sbjct: 136 PFAVISLMIGGVAVRLVPDDIVIPGGVNATN------GTEARDALRVKVAMSVTLLSGII 189

Query: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259
           Q   G  + GF+  YL +PLV GFTTAAA  V  S LK +  V TK Y+G+ S++Y+ V 
Sbjct: 190 QFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVA 249

Query: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319
           + QN+ + N+     GL+   + +  KE N+RF+ K+P PIP+E    ++ T IS G NL
Sbjct: 250 VLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNL 309

Query: 320 EKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTI 379
           +++YN  +V ++P G LPP  P  SLF  +   + +IA+V +++ +S+ K  A K+ Y +
Sbjct: 310 KESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQV 369

Query: 380 DGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439
           DGNQE IA G+ N     F  F  + +LSR+ VQE TGGKTQ+AG +++ ++++ ILA G
Sbjct: 370 DGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATG 429

Query: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLL 499
            L E L ++VL+A+VI NLKGMFMQ  D+P  WR +KI+  IW+ T + S+ LGLD GL+
Sbjct: 430 FLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLI 489

Query: 500 AGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNV 559
             +I  LLTV+ R Q PS+  LG +P TD+Y     Y+ ++E  G+KI + ++PI+Y N 
Sbjct: 490 TAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANS 549

Query: 560 DGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDA-VSTNNAFEPD 618
           D +   +K   G +   +   R KA+RK  K + +  + A    + +DA V   +A +P+
Sbjct: 550 DLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANM-ANATVVKADAEVDGEDATKPE 608

Query: 619 EDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRV 678
           E     E+ ++    I I+  +  E+  +   P   +H+++LD   ++F+D VGV++L  
Sbjct: 609 E-----EDGEVKYPPIVIKSTFPEEMQ-RFMPPGDNVHTVILDFTQVNFIDSVGVKTLAG 662

Query: 679 IVKEFQRIDVNVYFASLQDYV 699
           IVKE+  + + VY A    ++
Sbjct: 663 IVKEYGDVGIYVYLAGCSAFI 683


>gi|16418413 solute carrier family 26, member 9 isoform a [Homo
           sapiens]
          Length = 791

 Score =  459 bits (1180), Expect = e-129
 Identities = 259/739 (35%), Positives = 409/739 (55%), Gaps = 36/739 (4%)

Query: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79
           Y+V R  YS   F  + E++      + E L     CS  +   V+  L+P+L WLPKY+
Sbjct: 8   YVVDRAAYSLTLFDDEFEKK-DRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYK 66

Query: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139
           +K++++ D++ G+S G +   QGMA+ALLA +P   GLYS+FFP+LTYF  G    +  G
Sbjct: 67  IKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPG 126

Query: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199
            F V+S++VG++ L +AP+  F V ++     N + +DTAA +  R+ +++ L  L  II
Sbjct: 127 TFAVISILVGNICLQLAPESKFQVFNN---ATNESYVDTAAMEAERLHVSATLACLTAII 183

Query: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259
           Q+  G +Q GF+  YL++  + GF TAA  Q+L+S LK +  ++  +Y G  SI++T ++
Sbjct: 184 QMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFID 243

Query: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319
           I +N+  TN+A     L++    + VKELN R+ HKI  PIP E+IV ++ATAIS G  +
Sbjct: 244 ICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKM 303

Query: 320 EKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTI 379
            K Y+  IV  I RGF  P  P VS + +M+  +FS+A+V+Y I +++G+  A K+ Y +
Sbjct: 304 PKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDV 363

Query: 380 DGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439
           D NQE IA G SN F  FF   V   ALS T   +  GGK+QVA +  + +VMI +L LG
Sbjct: 364 DSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLG 423

Query: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLL 499
             L PL KSVL A++  NLK    QL D   LWR++K+D  IWV + + S  L L  G+ 
Sbjct: 424 IYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVA 483

Query: 500 AGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNV 559
            G+ F +L VV + QF +   L  +  TDIY + K Y   ++ QG+KI+ + SP+++ N 
Sbjct: 484 VGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANS 543

Query: 560 DGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRAT-KNGIISDAVSTNNAFEPD 618
           + F++ + +  G D  +V   + K L+K +K     ++R T +   +     T +  E  
Sbjct: 544 EIFRQKVIAKTGMDPQKVLLAKQKYLKKQEK----RRMRPTQQRRSLFMKTKTVSLQELQ 599

Query: 619 EDIEDLEELDIPTKE----------IEIQVDWN----SELPVKVNVPKVP---------- 654
           +D E+    D    +          I    D +    SE P     P  P          
Sbjct: 600 QDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPF 659

Query: 655 --IHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDD- 711
              H+L+LD   +SF+D++G+++L  +   + +I V V+  ++   V   +   G F+D 
Sbjct: 660 VTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDG 719

Query: 712 NIRKDTFFLTVHDAILYLQ 730
           ++     F ++HDA+L+ Q
Sbjct: 720 SLECKHVFPSIHDAVLFAQ 738


>gi|217272867 solute carrier family 26, member 9 isoform b [Homo
           sapiens]
          Length = 887

 Score =  459 bits (1180), Expect = e-129
 Identities = 259/739 (35%), Positives = 409/739 (55%), Gaps = 36/739 (4%)

Query: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79
           Y+V R  YS   F  + E++      + E L     CS  +   V+  L+P+L WLPKY+
Sbjct: 8   YVVDRAAYSLTLFDDEFEKK-DRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYK 66

Query: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139
           +K++++ D++ G+S G +   QGMA+ALLA +P   GLYS+FFP+LTYF  G    +  G
Sbjct: 67  IKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPG 126

Query: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199
            F V+S++VG++ L +AP+  F V ++     N + +DTAA +  R+ +++ L  L  II
Sbjct: 127 TFAVISILVGNICLQLAPESKFQVFNN---ATNESYVDTAAMEAERLHVSATLACLTAII 183

Query: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259
           Q+  G +Q GF+  YL++  + GF TAA  Q+L+S LK +  ++  +Y G  SI++T ++
Sbjct: 184 QMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFID 243

Query: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319
           I +N+  TN+A     L++    + VKELN R+ HKI  PIP E+IV ++ATAIS G  +
Sbjct: 244 ICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKM 303

Query: 320 EKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTI 379
            K Y+  IV  I RGF  P  P VS + +M+  +FS+A+V+Y I +++G+  A K+ Y +
Sbjct: 304 PKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDV 363

Query: 380 DGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439
           D NQE IA G SN F  FF   V   ALS T   +  GGK+QVA +  + +VMI +L LG
Sbjct: 364 DSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLG 423

Query: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLL 499
             L PL KSVL A++  NLK    QL D   LWR++K+D  IWV + + S  L L  G+ 
Sbjct: 424 IYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVA 483

Query: 500 AGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNV 559
            G+ F +L VV + QF +   L  +  TDIY + K Y   ++ QG+KI+ + SP+++ N 
Sbjct: 484 VGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANS 543

Query: 560 DGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRAT-KNGIISDAVSTNNAFEPD 618
           + F++ + +  G D  +V   + K L+K +K     ++R T +   +     T +  E  
Sbjct: 544 EIFRQKVIAKTGMDPQKVLLAKQKYLKKQEK----RRMRPTQQRRSLFMKTKTVSLQELQ 599

Query: 619 EDIEDLEELDIPTKE----------IEIQVDWN----SELPVKVNVPKVP---------- 654
           +D E+    D    +          I    D +    SE P     P  P          
Sbjct: 600 QDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPF 659

Query: 655 --IHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDD- 711
              H+L+LD   +SF+D++G+++L  +   + +I V V+  ++   V   +   G F+D 
Sbjct: 660 VTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDG 719

Query: 712 NIRKDTFFLTVHDAILYLQ 730
           ++     F ++HDA+L+ Q
Sbjct: 720 SLECKHVFPSIHDAVLFAQ 738


>gi|100913030 solute carrier family 26 member 2 [Homo sapiens]
          Length = 739

 Score =  444 bits (1142), Expect = e-124
 Identities = 246/725 (33%), Positives = 407/725 (56%), Gaps = 61/725 (8%)

Query: 27  YSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLS 86
           Y  +  ++Q +     ++ + + L K C CS  +A  ++   +P+L+WLPKY +K+ +L 
Sbjct: 51  YHRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILG 110

Query: 87  DVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSL 146
           DV+SG+  G++   Q +AY+LLA     YGLY++FF  + YF+ GTSRHISVG F V+ L
Sbjct: 111 DVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCL 170

Query: 147 MVGSVV--------LSMAPDEHFLVSSSNG-TVLNTTMIDTAARDTARVLIASALTLLVG 197
           M+G  V           A     L   SNG T+LN T      +    +++ S +T + G
Sbjct: 171 MIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAG 230

Query: 198 IIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTL 257
           + Q+  G  Q+GF+  YL+D L+ GF T A+F +L SQ K +L ++    NGV S+I T 
Sbjct: 231 VYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTW 290

Query: 258 VEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGA 317
           + +F+NI  TNL D    LL ++V +  KELN+ F+ K+  PIPIE++V + AT  S+  
Sbjct: 291 IHVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFG 350

Query: 318 NLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDY 377
            L +NYN+ I   IP GF+PP++P  +L   +   + +I+++ +AI VS+ +++A K+ Y
Sbjct: 351 KLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGY 410

Query: 378 TIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILA 437
           T+  NQE  A G  NI   FF CF  + AL++T V+ESTG  TQ++G+++A ++++ +L 
Sbjct: 411 TVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLV 470

Query: 438 LGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLG 497
           +  L   LQKSVL  + I NL+G   +  D+P++W  +++D VIW  T + S +L  ++G
Sbjct: 471 IAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIG 530

Query: 498 LLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYG 557
           LL G+ F +  V+LR Q P  + LG +  +++++S   YKN++   G+KI RF +P++Y 
Sbjct: 531 LLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYI 590

Query: 558 NVDGFKKCI-KSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFE 616
           N + FK  + K TV    I+V  K+  A RKI++ +       T  GI            
Sbjct: 591 NKECFKSALYKQTVNPILIKVAWKK-AAKRKIKEKV------VTLGGI------------ 631

Query: 617 PDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSL 676
                                     E+ V+++   + +H++V+DC AI FLD  G+ +L
Sbjct: 632 ------------------------QDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTL 667

Query: 677 RVIVKEFQRIDVNVYFASLQDYVIEKL---EQCGFFDDNIRKDTFFLTVHDAILYLQNQV 733
           + + ++++ I + V  A     V + L   E C   ++N+     F +V++A+ + +   
Sbjct: 668 KEVRRDYEAIGIQVLLAQCNPTVRDSLTNGEYCKKEEENL----LFYSVYEAMAFAEVS- 722

Query: 734 KSQEG 738
           K+Q+G
Sbjct: 723 KNQKG 727


>gi|45827802 prestin isoform c [Homo sapiens]
          Length = 516

 Score =  438 bits (1126), Expect = e-122
 Identities = 211/495 (42%), Positives = 318/495 (64%), Gaps = 6/495 (1%)

Query: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79
           Y V RP++S    Q++   + +   ++ + L +  +C+ K+   ++   +PI +WLP Y+
Sbjct: 16  YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYK 75

Query: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139
            KE++L D++SG+STG++   QG+A+A+LAAVP  +GLYS+F+P++ Y   GTSRHIS+G
Sbjct: 76  FKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIG 135

Query: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199
           PF V+SLM+G V + + PD+  +    N T        T ARD  RV +A ++TLL GII
Sbjct: 136 PFAVISLMIGGVAVRLVPDDIVIPGGVNATN------GTEARDALRVKVAMSVTLLSGII 189

Query: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259
           Q   G  + GF+  YL +PLV GFTTAAA  V  S LK +  V TK Y+G+ S++Y+ V 
Sbjct: 190 QFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVA 249

Query: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319
           + QN+ + N+     GL+   + +  KE N+RF+ K+P PIP+E    ++ T IS G NL
Sbjct: 250 VLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNL 309

Query: 320 EKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTI 379
           +++YN  +V ++P G LPP  P  SLF  +   + +IA+V +++ +S+ K  A K+ Y +
Sbjct: 310 KESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQV 369

Query: 380 DGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439
           DGNQE IA G+ N     F  F  + +LSR+ VQE TGGKTQ+AG +++ ++++ ILA G
Sbjct: 370 DGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATG 429

Query: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLL 499
            L E L ++VL+A+VI NLKGMFMQ  D+P  WR +KI+  IW+ T + S+ LGLD GL+
Sbjct: 430 FLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLI 489

Query: 500 AGLIFGLLTVVLRVQ 514
             +I  LLTV+ R Q
Sbjct: 490 TAVIIALLTVIYRTQ 504


>gi|47131207 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  404 bits (1037), Expect = e-112
 Identities = 227/700 (32%), Positives = 381/700 (54%), Gaps = 59/700 (8%)

Query: 43  RKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQG 102
           R+ L+  L   CSCS      +++ L+P   WL +YR +E+L  DV+SG+  G++   Q 
Sbjct: 28  REMLKARLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQA 87

Query: 103 MAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVV---LSMA--- 156
           +AY+LLA +   Y LY++FF  L YF+ GTSRH+SVG F ++ LMVG VV   L +A   
Sbjct: 88  IAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFD 147

Query: 157 PDEHFLVSSSNGTVLN--TTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRY 214
           P +  L   +N + LN    M+D   RD   + +A+ALTL+ G+ Q++ G L++GF+  Y
Sbjct: 148 PSQDGLQPGANSSTLNGSAAMLD-CGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAY 206

Query: 215 LADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTA 274
           L+ PL+ GF   A+  +L SQLK +L V    + G   ++ T + + +  G  N+ D   
Sbjct: 207 LSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVT 266

Query: 275 GLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRG 334
             + + V +A KEL+DR+RH++ VP+P E++V ++AT +S+   L K + + +   IP G
Sbjct: 267 STVCLAVLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTG 326

Query: 335 FLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIF 394
           F+PP++P   L   +   + ++A+VA A ++S+ +++A  + Y++  NQE +A G  N+ 
Sbjct: 327 FMPPQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVL 386

Query: 395 SGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVV 454
             F  CF  + AL+++ V+ +TG +TQ++ ++SA +V++ +LAL  L   LQ+SVLA V+
Sbjct: 387 PAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVI 446

Query: 455 IANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQ 514
           + +L+G   ++ D+PRLWR +  DA++W  T    +++  + GLLAG+I  LL++  R Q
Sbjct: 447 VVSLRGALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQ 506

Query: 515 FPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDA 574
            P    L  I  T  Y+    ++ +    GV++ RF  P++Y N D F + + S  G DA
Sbjct: 507 RPRTALLARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDA 566

Query: 575 IRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEI 634
             +  +R           K G    ++ G+     +           EDL          
Sbjct: 567 GCMAARR-----------KEG---GSETGVGEGGPAQG---------EDLG--------- 594

Query: 635 EIQVDWNSELPVKVNVPKVP----IHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNV 690
                     PV      VP     H++V+DC  + FLD  GV +L+ + +++  + +++
Sbjct: 595 ----------PVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISL 644

Query: 691 YFASLQDYVIEKLEQCGFF----DDNIRKDTFFLTVHDAI 726
             A     V + L + GF      D   ++  FL+VHDA+
Sbjct: 645 LLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAV 684


>gi|20336272 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  404 bits (1037), Expect = e-112
 Identities = 227/700 (32%), Positives = 381/700 (54%), Gaps = 59/700 (8%)

Query: 43  RKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQG 102
           R+ L+  L   CSCS      +++ L+P   WL +YR +E+L  DV+SG+  G++   Q 
Sbjct: 28  REMLKARLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQA 87

Query: 103 MAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVV---LSMA--- 156
           +AY+LLA +   Y LY++FF  L YF+ GTSRH+SVG F ++ LMVG VV   L +A   
Sbjct: 88  IAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFD 147

Query: 157 PDEHFLVSSSNGTVLN--TTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRY 214
           P +  L   +N + LN    M+D   RD   + +A+ALTL+ G+ Q++ G L++GF+  Y
Sbjct: 148 PSQDGLQPGANSSTLNGSAAMLD-CGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAY 206

Query: 215 LADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTA 274
           L+ PL+ GF   A+  +L SQLK +L V    + G   ++ T + + +  G  N+ D   
Sbjct: 207 LSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVT 266

Query: 275 GLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRG 334
             + + V +A KEL+DR+RH++ VP+P E++V ++AT +S+   L K + + +   IP G
Sbjct: 267 STVCLAVLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTG 326

Query: 335 FLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIF 394
           F+PP++P   L   +   + ++A+VA A ++S+ +++A  + Y++  NQE +A G  N+ 
Sbjct: 327 FMPPQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVL 386

Query: 395 SGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVV 454
             F  CF  + AL+++ V+ +TG +TQ++ ++SA +V++ +LAL  L   LQ+SVLA V+
Sbjct: 387 PAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVI 446

Query: 455 IANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQ 514
           + +L+G   ++ D+PRLWR +  DA++W  T    +++  + GLLAG+I  LL++  R Q
Sbjct: 447 VVSLRGALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQ 506

Query: 515 FPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDA 574
            P    L  I  T  Y+    ++ +    GV++ RF  P++Y N D F + + S  G DA
Sbjct: 507 RPRTALLARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDA 566

Query: 575 IRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEI 634
             +  +R           K G    ++ G+     +           EDL          
Sbjct: 567 GCMAARR-----------KEG---GSETGVGEGGPAQG---------EDLG--------- 594

Query: 635 EIQVDWNSELPVKVNVPKVP----IHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNV 690
                     PV      VP     H++V+DC  + FLD  GV +L+ + +++  + +++
Sbjct: 595 ----------PVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISL 644

Query: 691 YFASLQDYVIEKLEQCGFF----DDNIRKDTFFLTVHDAI 726
             A     V + L + GF      D   ++  FL+VHDA+
Sbjct: 645 LLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAV 684


>gi|20336282 solute carrier family 26, member 7 isoform b [Homo
           sapiens]
          Length = 663

 Score =  323 bits (828), Expect = 4e-88
 Identities = 206/667 (30%), Positives = 339/667 (50%), Gaps = 51/667 (7%)

Query: 69  VPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYF 128
           +PIL+W P Y +KE LL D +SG+   +    QG+A+A+L++V   +GLY + FP + Y 
Sbjct: 32  LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91

Query: 129 IFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLI 188
           IFG   H++ G F + SL+  + V  + P     +++ +    NT+++  +  +  R+ +
Sbjct: 92  IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQS----NTSVLGLSDFEMQRIHV 147

Query: 189 ASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYN 248
           A+A++ L G+IQ+    LQ+G     + +P++   TT AA  V+ SQ+K +L +     +
Sbjct: 148 AAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYIS 207

Query: 249 GVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTI 308
           G L   Y    +F+NI    L      LL+IVV + VKELN++F+ KI V +P+++++ I
Sbjct: 208 GPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLII 267

Query: 309 IATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVG 368
            A+   Y  N+E  Y   +V  IP+G   P  PP+++ S ++  +F +A+V Y  ++++ 
Sbjct: 268 AASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALA 327

Query: 369 KVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISA 428
           +  A K+ Y+ID NQEF+A G+SNI S FF C  +  A+ RTA   STG KTQVA +IS 
Sbjct: 328 QGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISC 387

Query: 429 AIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIV 488
             V+I I A+G LL  L   VLA++++  LKGM +Q  D+ + W  +KID  IWV T + 
Sbjct: 388 IFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVF 447

Query: 489 SIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKIL 548
           +I    ++GLL G++  +  V+ R  FP    +      ++    K   + E  Q VKI+
Sbjct: 448 TICFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKII 505

Query: 549 RFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDA 608
             ++P+ + N   F      T   + I+  N   + L  I K  ++  L +  NG  ++ 
Sbjct: 506 SINNPLVFLNAKKF-----YTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEE 560

Query: 609 VSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFL 668
            S +    P+E                                      L+LDC   +F 
Sbjct: 561 ASQSC---PNEKC-----------------------------------YLILDCSGFTFF 582

Query: 669 DVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILY 728
           D  GV  L  +  + +   V+V  A     +I+ +   G  D    K  FF +V  AI +
Sbjct: 583 DYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDS--EKPIFFESVSAAISH 640

Query: 729 LQNQVKS 735
           + +   S
Sbjct: 641 IHSNKAS 647


>gi|16306483 solute carrier family 26, member 7 isoform a [Homo
           sapiens]
          Length = 656

 Score =  323 bits (827), Expect = 5e-88
 Identities = 205/663 (30%), Positives = 338/663 (50%), Gaps = 51/663 (7%)

Query: 69  VPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYF 128
           +PIL+W P Y +KE LL D +SG+   +    QG+A+A+L++V   +GLY + FP + Y 
Sbjct: 32  LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91

Query: 129 IFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLI 188
           IFG   H++ G F + SL+  + V  + P     +++ +    NT+++  +  +  R+ +
Sbjct: 92  IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQS----NTSVLGLSDFEMQRIHV 147

Query: 189 ASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYN 248
           A+A++ L G+IQ+    LQ+G     + +P++   TT AA  V+ SQ+K +L +     +
Sbjct: 148 AAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYIS 207

Query: 249 GVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTI 308
           G L   Y    +F+NI    L      LL+IVV + VKELN++F+ KI V +P+++++ I
Sbjct: 208 GPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLII 267

Query: 309 IATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVG 368
            A+   Y  N+E  Y   +V  IP+G   P  PP+++ S ++  +F +A+V Y  ++++ 
Sbjct: 268 AASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALA 327

Query: 369 KVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISA 428
           +  A K+ Y+ID NQEF+A G+SNI S FF C  +  A+ RTA   STG KTQVA +IS 
Sbjct: 328 QGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISC 387

Query: 429 AIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIV 488
             V+I I A+G LL  L   VLA++++  LKGM +Q  D+ + W  +KID  IWV T + 
Sbjct: 388 IFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVF 447

Query: 489 SIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKIL 548
           +I    ++GLL G++  +  V+ R  FP    +      ++    K   + E  Q VKI+
Sbjct: 448 TICFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKII 505

Query: 549 RFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDA 608
             ++P+ + N   F      T   + I+  N   + L  I K  ++  L +  NG  ++ 
Sbjct: 506 SINNPLVFLNAKKF-----YTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEE 560

Query: 609 VSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFL 668
            S +    P+E                                      L+LDC   +F 
Sbjct: 561 ASQSC---PNEKC-----------------------------------YLILDCSGFTFF 582

Query: 669 DVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILY 728
           D  GV  L  +  + +   V+V  A     +I+ +   G  D    K  FF +V  AI +
Sbjct: 583 DYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDS--EKPIFFESVSAAISH 640

Query: 729 LQN 731
           + +
Sbjct: 641 IHS 643


>gi|16418457 solute carrier family 26, member 8 isoform a [Homo
           sapiens]
          Length = 970

 Score =  292 bits (747), Expect = 9e-79
 Identities = 210/808 (25%), Positives = 383/808 (47%), Gaps = 83/808 (10%)

Query: 17  SCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKC-----CSCSRKRAFGVLKTLVPI 71
           S +Y V R VY+E  FQQ+H+R+      +  ++        C CS  R    + T+ P 
Sbjct: 20  SFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPF 79

Query: 72  LEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAA--VPVGYGLYSAFFPILTYFI 129
           LEW+  YR+K+WLL D+++G+S GLV   QG+  +LLA   +P     Y+AF   + Y I
Sbjct: 80  LEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVI 139

Query: 130 FGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVL-- 187
           FG+   +S+G F +VS ++ +V L ++P        +NG ++  + +       + ++  
Sbjct: 140 FGSCHQMSIGSFFLVSALLINV-LKVSP-------FNNGQLVMGSFVKNEFSAPSYLMGY 191

Query: 188 -----IASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNV 242
                + +  T L GIIQLI G L +GFI  YL +  +  +  A A  +++SQL  +  +
Sbjct: 192 NKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGI 251

Query: 243 STKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPI 302
               + G +S  Y ++     +   N        LT+VV + + +      ++ P+  P+
Sbjct: 252 MISFHAGPISFFYDIINYCVALPKANSTSILV-FLTVVVALRINKCIRISFNQYPIEFPM 310

Query: 303 EVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYA 362
           E+ + I  T I+   ++    +  ++  IP  FL P  P  SL  +++  +FS+++V+  
Sbjct: 311 ELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSF 370

Query: 363 IAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQV 422
           + + +GK  A+ ++Y+++ NQ+ IA G+ N+ S FF   V T A++RT +Q+ +GG+ Q 
Sbjct: 371 LLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQF 430

Query: 423 AGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIW 482
           A ++ A ++++ ++ +G     L  +VLA ++++N+      + ++P LWRQ++ D  +W
Sbjct: 431 ASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALW 490

Query: 483 VFTCIVSIILGLDLGLLAGLI--FGLLTV-------VLRVQFPSWNGLGSI--------- 524
           + T   SI LGLD+GL+  ++  F + TV       +L  Q P+ N   SI         
Sbjct: 491 MMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITI 550

Query: 525 PSTDIYKSTKN----------YKNIEEPQGVKILRFSSPIFY------GNVDGFKKCIKS 568
           P   I++   +          +K ++E   VK+      IF        N+ G K C + 
Sbjct: 551 PGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKIC-RC 609

Query: 569 TVGFDAIRVYNKRLKALRKIQKLIKSGQL---------------RATKNGIISDAVSTNN 613
               D +    + L   R   KL                     +      +   VS+ +
Sbjct: 610 FCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVS 669

Query: 614 AFEPDEDIEDLEELDIPTK----------EIEIQVDWNSELPVKVNVPKVPIHSLVLDCG 663
                +  E++EE+ +P            ++       S +P         +H+++LD  
Sbjct: 670 QKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFS 729

Query: 664 AISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVH 723
            + ++D  G+  LR I   FQ  ++ +  A     ++   E+  FFD  I K   FL+VH
Sbjct: 730 MVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVH 789

Query: 724 DAILYLQNQVKSQEGQGSILETITLIQD 751
           DA+L+  ++      + SI E+ T+I++
Sbjct: 790 DAVLFALSRKVIGSSELSIDESETVIRE 817


>gi|65506789 solute carrier family 26, member 10 [Homo sapiens]
          Length = 563

 Score =  276 bits (706), Expect = 5e-74
 Identities = 152/410 (37%), Positives = 245/410 (59%), Gaps = 10/410 (2%)

Query: 81  KEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGP 140
           K W L    S   T    ++ GMA+ALLA+VP  +GLY++FFP+L Y + GT RH+S G 
Sbjct: 20  KSWRLDKAPSPQHTFPSTSIPGMAFALLASVPPVFGLYTSFFPVLIYSLLGTGRHLSTGT 79

Query: 141 FPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQ 200
           F ++SLM GS V  + P+   LV + +G       I+    D  RV +A+A+    G + 
Sbjct: 80  FAILSLMTGSAVERLVPEP--LVGNLSG-------IEKEQLDAQRVGVAAAVAFGSGALM 130

Query: 201 LIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEI 260
           L    LQ+G +  +L++P+V   T+ AA  VL+SQL  +L +S     G  S+  TL  +
Sbjct: 131 LGMFVLQLGVLSTFLSEPVVKALTSGAALHVLLSQLPSLLGLSLPRQIGCFSLFKTLASL 190

Query: 261 FQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLE 320
              +  ++ A+ T   L++ + + VKELN RFR ++P PIP EV++ ++A+ + + ++++
Sbjct: 191 LTALPRSSPAELTISALSLALLVPVKELNVRFRDRLPTPIPGEVVLVLLASVLCFTSSVD 250

Query: 321 KNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTID 380
             Y   IV  +P GF  P LP ++    +LA S  IA+V++A++ S+  ++A KY YTID
Sbjct: 251 TRYQVQIVGLLPGGFPQPLLPNLAELPRILADSLPIALVSFAVSASLASIHADKYSYTID 310

Query: 381 GNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGK 440
            NQEF+A G SN+ S  FSCF  +  L+ T +    GGKTQ+AG+ S  +V+  +L LG 
Sbjct: 311 SNQEFLAHGASNLISSLFSCFPNSATLATTNLLVDAGGKTQLAGLFSCTVVLSVLLWLGP 370

Query: 441 LLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWV-FTCIVS 489
               L K+VLA + I++++ +F Q+ ++P+LW  +++D ++ V   CI+S
Sbjct: 371 FFYYLPKAVLACINISSMRQVFCQMQELPQLWHISRVDFLLQVPGLCILS 420


>gi|45827804 prestin isoform d [Homo sapiens]
          Length = 335

 Score =  271 bits (694), Expect = 1e-72
 Identities = 129/316 (40%), Positives = 200/316 (63%), Gaps = 6/316 (1%)

Query: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79
           Y V RP++S    Q++   + +   ++ + L +  +C+ K+   ++   +PI +WLP Y+
Sbjct: 16  YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYK 75

Query: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139
            KE++L D++SG+STG++   QG+A+A+LAAVP  +GLYS+F+P++ Y   GTSRHIS+G
Sbjct: 76  FKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIG 135

Query: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199
           PF V+SLM+G V + + PD+  +    N T        T ARD  RV +A ++TLL GII
Sbjct: 136 PFAVISLMIGGVAVRLVPDDIVIPGGVNATN------GTEARDALRVKVAMSVTLLSGII 189

Query: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259
           Q   G  + GF+  YL +PLV GFTTAAA  V  S LK +  V TK Y+G+ S++Y+ V 
Sbjct: 190 QFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVA 249

Query: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319
           + QN+ + N+     GL+   + +  KE N+RF+ K+P PIP+E    ++ T IS G NL
Sbjct: 250 VLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNL 309

Query: 320 EKNYNAGIVKSIPRGF 335
           +++YN  +V ++P GF
Sbjct: 310 KESYNVDVVGTLPLGF 325


>gi|217272870 solute carrier family 26, member 9 isoform c [Homo
           sapiens]
          Length = 459

 Score =  216 bits (551), Expect = 5e-56
 Identities = 131/410 (31%), Positives = 211/410 (51%), Gaps = 32/410 (7%)

Query: 349 MLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALS 408
           M+  +FS+A+V+Y I +++G+  A K+ Y +D NQE IA G SN F  FF   V   ALS
Sbjct: 1   MIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS 60

Query: 409 RTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDI 468
            T   +  GGK+QVA +  + +VMI +L LG  L PL KSVL A++  NLK    QL D 
Sbjct: 61  VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDP 120

Query: 469 PRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTD 528
             LWR++K+D  IWV + + S  L L  G+  G+ F +L VV + QF +   L  +  TD
Sbjct: 121 YYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTD 180

Query: 529 IYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKI 588
           IY + K Y   ++ QG+KI+ + SP+++ N + F++ + +  G D  +V   + K L+K 
Sbjct: 181 IYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQ 240

Query: 589 QKLIKSGQLRAT-KNGIISDAVSTNNAFEPDEDIEDLEELDIPTKE----------IEIQ 637
           +K     ++R T +   +     T +  E  +D E+    D    +          I   
Sbjct: 241 EK----RRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFS 296

Query: 638 VDWN----SELPVKVNVPKVP------------IHSLVLDCGAISFLDVVGVRSLRVIVK 681
            D +    SE P     P  P             H+L+LD   +SF+D++G+++L  +  
Sbjct: 297 PDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSS 356

Query: 682 EFQRIDVNVYFASLQDYVIEKLEQCGFFDD-NIRKDTFFLTVHDAILYLQ 730
            + +I V V+  ++   V   +   G F+D ++     F ++HDA+L+ Q
Sbjct: 357 TYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQ 406


>gi|85540447 solute carrier family 26, member 11 [Homo sapiens]
          Length = 606

 Score =  177 bits (448), Expect = 4e-44
 Identities = 131/484 (27%), Positives = 220/484 (45%), Gaps = 68/484 (14%)

Query: 54  CSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPV 113
           C CS       L+  +PIL WLP Y + +WL  D ++G+S GL A  Q +AYA +A +P 
Sbjct: 23  CCCSP----AALQRRLPILAWLPSYSL-QWLKMDFVAGLSVGLTAIPQALAYAEVAGLPP 77

Query: 114 GYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNT 173
            YGLYSAF     YF  GTSR +++GP  ++SL+V                         
Sbjct: 78  QYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVSFYTFH------------------- 118

Query: 174 TMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLV 233
                          A  L  L G IQL  G L++GF++ +++ P++ GFT+AAA  +  
Sbjct: 119 -----------EPAYAVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGF 167

Query: 234 SQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFR 293
            Q+K +L +        L + +T    F  I +T + D   GL+ +++ + +K + D   
Sbjct: 168 GQIKNLLGLQNIPRPFFLQVYHT----FLRIAETRVGDAVLGLVCMLLLLVLKLMRDHVP 223

Query: 294 HKIPVPIP---------------IEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPP 338
              P   P                  +V   A  ++Y   +       +      G  P 
Sbjct: 224 PVHPEMPPGVRLSRGLVWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPV 283

Query: 339 ELPPVSL--------FSEML----AASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFI 386
            +PP S+        F+EM+    A    + ++    +++V K +A++ +Y ID NQE +
Sbjct: 284 RIPPFSVTTANGTISFTEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELL 343

Query: 387 AFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQ 446
           A G++N+     S +  T +  RTAV   +G  T   G+++  +V++++  L  L   + 
Sbjct: 344 AIGLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIP 403

Query: 447 KSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGL 506
           KS LAAV+I  +  +F        LWR  ++D +    T ++     +  G+LAG +  L
Sbjct: 404 KSALAAVIIMAVAPLF-DTKIFRTLWRVKRLDLLPLCVTFLL-CFWEVQYGILAGALVSL 461

Query: 507 LTVV 510
           L ++
Sbjct: 462 LMLL 465


>gi|20336285 solute carrier family 26, member 8 isoform b [Homo
           sapiens]
          Length = 865

 Score =  163 bits (412), Expect = 7e-40
 Identities = 125/504 (24%), Positives = 231/504 (45%), Gaps = 64/504 (12%)

Query: 307 TIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVS 366
           T+IA  IS      +     ++  IP  FL P  P  SL  +++  +FS+++V+  + + 
Sbjct: 214 TVIANKISMATETSQT----LIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIF 269

Query: 367 VGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGII 426
           +GK  A+ ++Y+++ NQ+ IA G+ N+ S FF   V T A++RT +Q+ +GG+ Q A ++
Sbjct: 270 LGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLV 329

Query: 427 SAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTC 486
            A ++++ ++ +G     L  +VLA ++++N+      + ++P LWRQ++ D  +W+ T 
Sbjct: 330 GAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTF 389

Query: 487 IVSIILGLDLGLLAGLI--FGLLTV-------VLRVQFPSWNGLGSI---------PSTD 528
             SI LGLD+GL+  ++  F + TV       +L  Q P+ N   SI         P   
Sbjct: 390 SSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVK 449

Query: 529 IYKSTKN----------YKNIEEPQGVKILRFSSPIFY------GNVDGFKKCIKSTVGF 572
           I++   +          +K ++E   VK+      IF        N+ G K C +     
Sbjct: 450 IFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKIC-RCFCNC 508

Query: 573 DAIRVYNKRLKALRKIQKLIKSGQL---------------RATKNGIISDAVSTNNAFEP 617
           D +    + L   R   KL                     +      +   VS+ +    
Sbjct: 509 DDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQ 568

Query: 618 DEDIEDLEELDIPTK----------EIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISF 667
            +  E++EE+ +P            ++       S +P         +H+++LD   + +
Sbjct: 569 GQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHY 628

Query: 668 LDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAIL 727
           +D  G+  LR I   FQ  ++ +  A     ++   E+  FFD  I K   FL+VHDA+L
Sbjct: 629 VDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVL 688

Query: 728 YLQNQVKSQEGQGSILETITLIQD 751
           +  ++      + SI E+ T+I++
Sbjct: 689 FALSRKVIGSSELSIDESETVIRE 712



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 63/200 (31%), Positives = 105/200 (52%), Gaps = 22/200 (11%)

Query: 17  SCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKC-----CSCSRKRAFGVLKTLVPI 71
           S +Y V R VY+E  FQQ+H+R+      +  ++        C CS  R    + T+ P 
Sbjct: 20  SFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPF 79

Query: 72  LEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLA--AVPVGYGLYSAFFPILTYFI 129
           LEW+  YR+K+WLL D+++G+S GLV   QG+  +LLA   +P     Y+AF   + Y I
Sbjct: 80  LEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVI 139

Query: 130 FGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVL-- 187
           FG+   +S+G F +VS ++ + VL ++P        +NG ++  + +       + ++  
Sbjct: 140 FGSCHQMSIGSFFLVSALLIN-VLKVSP-------FNNGQLVMGSFVKNEFSAPSYLMGY 191

Query: 188 -----IASALTLLVGIIQLI 202
                + +  T L GIIQ+I
Sbjct: 192 NKSLSVVATTTFLTGIIQII 211


>gi|20336274 solute carrier family 26, member 1 isoform b [Homo
           sapiens]
          Length = 224

 Score =  114 bits (285), Expect = 3e-25
 Identities = 68/170 (40%), Positives = 101/170 (59%), Gaps = 9/170 (5%)

Query: 43  RKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQG 102
           R+ L+  L   CSCS      +++ L+P   WL +YR +E+L  DV+SG+  G++   Q 
Sbjct: 28  REMLKARLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQA 87

Query: 103 MAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVV---LSMA--- 156
           +AY+LLA +   Y LY++FF  L YF+ GTSRH+SVG F ++ LMVG VV   L +A   
Sbjct: 88  IAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFD 147

Query: 157 PDEHFLVSSSNGTVLN--TTMIDTAARDTARVLIASALTLLVGIIQLIFG 204
           P +  L   +N + LN    M+D   RD   + +A+ALTL+ G+ Q  +G
Sbjct: 148 PSQDGLQPGANSSTLNGSAAMLD-CGRDCYAIRVATALTLMTGLYQTSWG 196


>gi|7706575 transmembrane 7 superfamily member 3 [Homo sapiens]
          Length = 570

 Score = 31.6 bits (70), Expect = 3.0
 Identities = 43/141 (30%), Positives = 57/141 (40%), Gaps = 29/141 (20%)

Query: 388 FGISNIFSGFFSCFVATTA--------LSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439
           F I  I  GFF   + T          L  TAV  S GG   VA      I+ I +L +G
Sbjct: 321 FFIGFIIMGFFFYILITRLTPIKYDVNLILTAVTGSVGGMFLVAVWWRFGILSICMLCVG 380

Query: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWV-FTCIVSIILGLDLGL 498
            +L  L  SV     + NLK +F               D V WV F+CI  +I  + +G 
Sbjct: 381 LVLGFLISSVTFFTPLGNLK-IFHD-------------DGVFWVTFSCIAILIPVVFMGC 426

Query: 499 LAGL------IFGLLTVVLRV 513
           L  L      + G  +VVL +
Sbjct: 427 LRILNILTCGVIGSYSVVLAI 447


>gi|153945707 endothelin converting enzyme 2 isoform C [Homo
          sapiens]
          Length = 255

 Score = 30.0 bits (66), Expect = 8.6
 Identities = 11/20 (55%), Positives = 14/20 (70%)

Query: 1  MAAPGGRSEPPQLPEYSCSY 20
          MA+PG    PP+LPE +C Y
Sbjct: 1  MASPGAGRAPPELPERNCGY 20


>gi|153945761 endothelin converting enzyme 2 isoform A [Homo
          sapiens]
          Length = 883

 Score = 30.0 bits (66), Expect = 8.6
 Identities = 11/20 (55%), Positives = 14/20 (70%)

Query: 1  MAAPGGRSEPPQLPEYSCSY 20
          MA+PG    PP+LPE +C Y
Sbjct: 1  MASPGAGRAPPELPERNCGY 20


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 30.0 bits (66), Expect = 8.6
 Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 1/76 (1%)

Query: 123  PILTYFIFGTSRHISVGP-FPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAAR 181
            P+ TY    +S   + G   P  +   GS  L+  P    LV SS  + L+TT +DT+  
Sbjct: 1072 PVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIP 1131

Query: 182  DTARVLIASALTLLVG 197
             T     +S+ T   G
Sbjct: 1132 VTTSTEASSSPTTAEG 1147


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,821,466
Number of Sequences: 37866
Number of extensions: 1069270
Number of successful extensions: 2995
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2897
Number of HSP's gapped (non-prelim): 59
length of query: 780
length of database: 18,247,518
effective HSP length: 110
effective length of query: 670
effective length of database: 14,082,258
effective search space: 9435112860
effective search space used: 9435112860
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.