Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4505195
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505195 mitogen-activated protein kinase kinase kinase 11
[Homo sapiens]
(847 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 1752 0.0
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 723 0.0
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 714 0.0
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 700 0.0
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 258 2e-68
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 254 2e-67
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 218 1e-56
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 218 1e-56
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 163 7e-40
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 162 9e-40
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 160 5e-39
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 160 6e-39
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 148 2e-35
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 148 2e-35
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 148 2e-35
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 148 2e-35
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 141 3e-33
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 141 3e-33
gi|4503787 fyn-related kinase [Homo sapiens] 140 6e-33
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 139 1e-32
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 139 1e-32
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 138 2e-32
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 138 2e-32
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 138 2e-32
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 138 2e-32
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 138 2e-32
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 138 2e-32
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 138 2e-32
gi|187475373 c-src tyrosine kinase [Homo sapiens] 137 4e-32
gi|4758078 c-src tyrosine kinase [Homo sapiens] 137 4e-32
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 1752 bits (4537), Expect = 0.0
Identities = 847/847 (100%), Positives = 847/847 (100%)
Query: 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL 60
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL
Sbjct: 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL 60
Query: 61 ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE 120
ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE
Sbjct: 61 ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE 120
Query: 121 EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK 180
EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK
Sbjct: 121 EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK 180
Query: 181 AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR 240
AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR
Sbjct: 181 AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR 240
Query: 241 DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS 300
DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS
Sbjct: 241 DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS 300
Query: 301 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA
Sbjct: 301 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
Query: 361 QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR 420
QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR
Sbjct: 361 QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR 420
Query: 421 EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR 480
EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR
Sbjct: 421 EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR 480
Query: 481 SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP 540
SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP
Sbjct: 481 SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP 540
Query: 541 GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL 600
GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL
Sbjct: 541 GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL 600
Query: 601 GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD 660
GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD
Sbjct: 601 GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD 660
Query: 661 LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV 720
LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV
Sbjct: 661 LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV 720
Query: 721 GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS 780
GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS
Sbjct: 721 GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS 780
Query: 781 FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP 840
FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP
Sbjct: 781 FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP 840
Query: 841 WVPEAGP 847
WVPEAGP
Sbjct: 841 WVPEAGP 847
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 723 bits (1865), Expect = 0.0
Identities = 430/909 (47%), Positives = 522/909 (57%), Gaps = 151/909 (16%)
Query: 42 ANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQV-GGQVGIFPSNYV 100
A PVWTA+FDYE +G +EL LR+GDRV+VLS+D A+SGDEGWW GQ+ G+VG+FPSNYV
Sbjct: 17 AGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYV 76
Query: 101 SRGGGPPPC-----EVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDIS 155
+ G P + F EL+LEE+IG+GGFGKVYR WRGE VAVKAAR DP++D +
Sbjct: 77 APGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPA 136
Query: 156 VTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL 215
VTAE V QEARLF L HPNIIAL+ CL P+LCLVMEYA GG LSR LAGRRVPPHVL
Sbjct: 137 VTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL 196
Query: 216 VNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWH 275
VNWAVQ+ARGM+YLH +A VP+IHRDLKS NIL+L+ IE+ ++ LKITDFGLAREWH
Sbjct: 197 VNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWH 256
Query: 276 KTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVA 335
KTT+MSAAGTYAWMAPEVI+ S FSK SDVWSFGVLLWELLTGEVPYR ID LAVAYGVA
Sbjct: 257 KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVA 316
Query: 336 VNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSM 395
+NKLTLPIPSTCPEPFA+L+ +CW DPH RPDF SIL++LE +E L +MP +SFHS+
Sbjct: 317 MNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSL 376
Query: 396 QEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFER 455
QE WK EIQ +FD+LR KEKEL SREEEL RAA+EQR Q EQLRRRE LA+ E+++ ER
Sbjct: 377 QEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVER 436
Query: 456 ELTLLLQQVDRERPHVRRRRGTFKRSK-LRARDGGERISMPLDFKHRITVQASPGLDRRR 514
EL LL+ Q+ +E+P VR+R+G FKRS+ L+ R+GG IS+P F+H+ITVQASP LD+R+
Sbjct: 437 ELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRK 496
Query: 515 NVFEVGPGDSPT-FPRFRAIQLEPAEPGQA-----------WGRQSPRRLEDSSNGERRA 562
P SP+ PR RAI+L P + G + W R P + E+ G+++
Sbjct: 497 GSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKG 556
Query: 563 CWAWGPSSPKPGEAQNGRRRSR-MDEATWYLDSD----DSSPLGSPSTPPALNGN----- 612
WGPSS E G R + + E + S SP +P P + N
Sbjct: 557 -RTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEF 615
Query: 613 ----------PPRPSLEPEEPKRPVPAERGSSSGTP-----------------KLIQRAL 645
PP P P P+PAE + P + AL
Sbjct: 616 AEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLAL 675
Query: 646 LRGTALLASLGLGRD------------------------------LQPPG---------G 666
L LL ++GLG D L PP G
Sbjct: 676 LGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVG 735
Query: 667 PGRERGESPT-----------------------------TPPTPTPAPCPT-EPPPSPLI 696
PG S T +PP PAP PT P +PL+
Sbjct: 736 PGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLV 795
Query: 697 CFSL----KTPDSPPTPAPLLLDLGIPVGQR-----SAKSPRREEEPRGGTVSPPP---- 743
L K P TP + + G R A R EP G P
Sbjct: 796 DLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDF 855
Query: 744 ----------GTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPS 793
R P PG P + L RPRP+ R R+DPW VS G + P
Sbjct: 856 PRLPDPQALFPARRRPPEFPGRPTT--LTFAPRPRPAASRPRLDPWKLVSFGRTLTISPP 913
Query: 794 PQPAPRRAP 802
+P +P
Sbjct: 914 SRPDTPESP 922
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 714 bits (1842), Expect = 0.0
Identities = 417/822 (50%), Positives = 528/822 (64%), Gaps = 82/822 (9%)
Query: 9 LKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANP---VWTALFDYEPSGQDELALRKG 65
L+ G+ + S GG GG S + G A+ +W AL+DYE G+DEL+LR+G
Sbjct: 3 LRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRG 62
Query: 66 DRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVS-----RGGGPPPCEVAS-----FQ 115
VEVLS+DAA+SGDEGWWAGQV ++GIFP+NYV+ PPP +S F+
Sbjct: 63 QLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFE 122
Query: 116 ELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPN 175
L L+E+IG GGFG+VYR +W+G+ VAVKAARQDP++D + AESVR+EARLFAML HPN
Sbjct: 123 RLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPN 182
Query: 176 IIALKAVCLEEPNLCLVMEYAAGGPLSRALAG---------------RRVPPHVLVNWAV 220
II L+ VCL++P+LCLV+E+A GG L+RALA RR+PPHVLVNWAV
Sbjct: 183 IIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAV 242
Query: 221 QIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQM 280
QIARGM YLH EA VP++HRDLKS+NILLL+ IE DD+ +KTLKITDFGLAREWH+TT+M
Sbjct: 243 QIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKM 302
Query: 281 SAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLT 340
S AGTYAWMAPEVIK+S FSKGSD+WS+GVLLWELLTGEVPYRGID LAVAYGVAVNKLT
Sbjct: 303 STAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT 362
Query: 341 LPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWK 400
LPIPSTCPEPFA+LM +CW QDPH RP FA IL+QL A+E V+ EMP++SFHSMQ+ WK
Sbjct: 363 LPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWK 422
Query: 401 REIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLL 460
EIQ +FDELR KEKEL SREEELTRAA +Q+SQ E L+RRE LA+ E++V EREL +L
Sbjct: 423 LEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNIL 482
Query: 461 LQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRR--NVFE 518
+ Q+++E+P V++R+G FKRS+L+ +D G RIS+P DF+H+ITVQASP LD+RR N
Sbjct: 483 IFQLNQEKPKVKKRKGKFKRSRLKLKD-GHRISLPSDFQHKITVQASPNLDKRRSLNSSS 541
Query: 519 VGPGDSPT-FPRFRAIQLEPAEPGQAWGRQSPRRLED----SSNGERRACWAWGPSSPKP 573
P SPT PR RAIQL E + WGR + R E+ N +++ C WGP+S +
Sbjct: 542 SSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGC-TWGPNSIQM 600
Query: 574 GEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNP-PRPSLEPEEP---KRPVPA 629
+ + + R R SD +SP ST N P SL ++P + P +
Sbjct: 601 KDRTDCKERIRP-------LSDGNSPW---STILIKNQKTMPLASLFVDQPGSCEEPKLS 650
Query: 630 ERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTE 689
G PK I+ L A + L LG+D Q E E + T + E
Sbjct: 651 PDGLEHRKPKQIK---LPSQAYI-DLPLGKDAQRENPAEAESWEEAASANAATVS---IE 703
Query: 690 PPPSPLICFS---LKTPDSPPTPAPLLLDLGIPVGQRSAKS--------PRREEEPRGG- 737
P+ + S KT + LL + + + R P+ E++ R G
Sbjct: 704 MTPTNSLSRSPQRKKTESALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGI 763
Query: 738 ---------TVSPP---PGTSRSAPGTPGTPRSPPLGLISRP 767
+ SPP P T A P P S LG++S P
Sbjct: 764 FQRASKSRRSASPPTSLPSTCGEASSPPSLPLSSALGILSTP 805
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 700 bits (1806), Expect = 0.0
Identities = 380/704 (53%), Positives = 475/704 (67%), Gaps = 44/704 (6%)
Query: 20 GSGGGGGGGGGRPEGSPKAAGYANP----------VWTALFDYEPSGQDELALRKGDRVE 69
G G G G E +AA P WTA+F+YE +G+DEL LR GD VE
Sbjct: 21 GEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVE 80
Query: 70 VLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSR----------GGGPPPCEVA------S 113
VLS+D+ +SGDEGWW GQ+ +VGIFPSNYV+ GG P C
Sbjct: 81 VLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEID 140
Query: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
F EL LEE+IGIGGFGKVYR W G+ VAVKAAR DPDEDIS T E+VRQEA+LFAML H
Sbjct: 141 FAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 200
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEA 233
PNIIAL+ VCL+EPNLCLVME+A GGPL+R L+G+R+PP +LVNWAVQIARGM+YLH EA
Sbjct: 201 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEA 260
Query: 234 LVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEV 293
+VP+IHRDLKS+NIL+LQ +E+ D+ +K LKITDFGLAREWH+TT+MSAAGTYAWMAPEV
Sbjct: 261 IVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEV 320
Query: 294 IKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQ 353
I+AS FSKGSDVWS+GVLLWELLTGEVP+RGID LAVAYGVA+NKL LPIPSTCPEPFA+
Sbjct: 321 IRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAK 380
Query: 354 LMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAK 413
LM DCW DPH RP F +IL QL +E EMP+DSFH +Q+ WK EIQ +FD+LRAK
Sbjct: 381 LMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAK 440
Query: 414 EKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRR 473
EKEL + EEELTRAA +Q++Q E LRRRE LA+ E+++ EREL +++ Q+ +E+P V++
Sbjct: 441 EKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKK 500
Query: 474 RRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVF--EVGPGDSPT-FPRF 530
R+G F++S+L+ +D G RIS+P DF+H+ TVQASP +D+R+++ P SPT PR
Sbjct: 501 RKGKFRKSRLKLKD-GNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRL 559
Query: 531 RAIQLEPAEPGQAWGRQSPRRLEDSSNGERRA----CWAWGPSSPKPGEAQNGRRRS--R 584
RAIQL P E + WGR S E+ E+RA WGP + E +G S R
Sbjct: 560 RAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQR 619
Query: 585 MDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRP--VPAERGSSSGTPKLIQ 642
++A L + SP ++G S P K P PA G +S L++
Sbjct: 620 REKANG-LSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTS----LME 674
Query: 643 RALLRGTALL-ASLGLGRDLQPPGGPGRERGESPTTPPTPTPAP 685
ALL + ++ + D + PG SP+ P P
Sbjct: 675 MALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFP 718
Score = 43.9 bits (102), Expect = 6e-04
Identities = 70/265 (26%), Positives = 87/265 (32%), Gaps = 77/265 (29%)
Query: 582 RSRMDEATWY---LDSDDSSPLGSPSTPPALN------GNPPRPSLEPEEPKRPVPAERG 632
RS DE Y + ++ PL + P +N P SL P P++
Sbjct: 865 RSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPS 924
Query: 633 SSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPP- 691
S TP AL T L + L P G G + TP+P+ P E P
Sbjct: 925 SHRRTPS--DGALKPETLLASRSPSSNGLSPSPGAGMLK--------TPSPSRDPGEFPR 974
Query: 692 -PSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAP 750
P P + F PPTP RR + T+ P
Sbjct: 975 LPDPNVVF-------PPTP-------------------RRWNTQQDSTLERPK------- 1001
Query: 751 GTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSD 810
L + RPRPS R R+DPW FVS PS S PA + T
Sbjct: 1002 ---------TLEFLPRPRPSANRQRLDPWWFVS----PSHARSTSPANSSSTETPSNLDS 1048
Query: 811 PFWDS----------PPANPFQGGP 825
F S P PFQ GP
Sbjct: 1049 CFASSSSTVEERPGLPALLPFQAGP 1073
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 258 bits (658), Expect = 2e-68
Identities = 202/603 (33%), Positives = 287/603 (47%), Gaps = 76/603 (12%)
Query: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
F+E+ + +G G G V+ G + GE VAVK R + DI + L H
Sbjct: 122 FEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDI-----------KHLRKLKH 170
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCE 232
PNII K VC + P C++ME+ A G L L AGR V P +LV+W++ IA GM+YLH
Sbjct: 171 PNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLH-- 228
Query: 233 ALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWH-KTTQMSAAGTYAWMAP 291
L +IHRDLKS N+L I DD+ +KI+DFG ++E K+T+MS AGT AWMAP
Sbjct: 229 -LHKIIHRDLKSPNML----ITYDDV----VKISDFGTSKELSDKSTKMSFAGTVAWMAP 279
Query: 292 EVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPF 351
EVI+ S+ D+WSFGV+LWELLTGE+PY+ +D A+ +GV N L LP+PS+CP+ F
Sbjct: 280 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF 339
Query: 352 AQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELR 411
L+ CW P RP F IL L+ A VL P++++ Q W+ E++ F++++
Sbjct: 340 KILLRQCWNSKPRNRPSFRQILLHLDIASADVL-STPQETYFKSQAEWREEVKLHFEKIK 398
Query: 412 AKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHV 471
++ L EEEL RE+ A +R + ++ L+LQ +ER +
Sbjct: 399 SEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELL 458
Query: 472 RRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFR 531
RR + +R + R H T++ L ++RNV + SP R
Sbjct: 459 RREQALERRCPGLLKPHPSR-----GLLHGNTMEK---LIKKRNVPQ---KLSPHSKRPD 507
Query: 532 AIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWY 591
++ E P +L+ + +G P P PG ++ G+ R R A
Sbjct: 508 ILKTESLLP----------KLDAALSGVGLPGCPKAP--PSPGRSRRGKTRHRKASAKGS 555
Query: 592 LDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERG---------SSSGTPKLIQ 642
P P G+P P + PA RG SS +P L+
Sbjct: 556 CGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLS 615
Query: 643 RAL-LRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEP---------PP 692
AL RG G PG P RG+ TPP+ AP T P PP
Sbjct: 616 AALGSRGRGATGGAG------DPGSPPPARGD---TPPSEGSAPGSTSPDSPGGAKGEPP 666
Query: 693 SPL 695
P+
Sbjct: 667 PPV 669
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 254 bits (649), Expect = 2e-67
Identities = 156/427 (36%), Positives = 230/427 (53%), Gaps = 38/427 (8%)
Query: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
F+E+ + +G G G V+ G +R E VA+K R+ + DI + L H
Sbjct: 165 FEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDI-----------KHLRKLKH 213
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCE 232
PNIIA K VC + P C++MEY A G L L AGR++ P +LV+W+ IA GM+YLH
Sbjct: 214 PNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLH-- 271
Query: 233 ALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWH-KTTQMSAAGTYAWMAP 291
L +IHRDLKS N+L+ +KI+DFG ++E K+T+MS AGT AWMAP
Sbjct: 272 -LHKIIHRDLKSPNVLVTHT--------DAVKISDFGTSKELSDKSTKMSFAGTVAWMAP 322
Query: 292 EVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPF 351
EVI+ S+ D+WSFGV+LWELLTGE+PY+ +D A+ +GV N L LP+PSTCP+ F
Sbjct: 323 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 382
Query: 352 AQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELR 411
LM W P RP F L L+ A VL P++++ Q W+ E++ F++++
Sbjct: 383 KILMKQTWQSKPRNRPSFRQTLMHLDIASADVL-ATPQETYFKSQAEWREEVKKHFEKIK 441
Query: 412 AKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHV 471
++ + +EEL R RE+ A +R + ++ ++LQ RE+ +
Sbjct: 442 SEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELI 501
Query: 472 RRRR-------GTFKRSKLRA---RDGGERISMPLDFKHRITVQAS-PGLDRRRNV--FE 518
+R + GT+KR +R + E++ H+ +Q P L R + E
Sbjct: 502 KREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTE 561
Query: 519 VGPGDSP 525
V P SP
Sbjct: 562 VAPTASP 568
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 218 bits (556), Expect = 1e-56
Identities = 131/352 (37%), Positives = 192/352 (54%), Gaps = 37/352 (10%)
Query: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE-SVRQEARLFAMLA 172
F +L+ E G G FG VYR W + D++++V + +EA + ++L+
Sbjct: 13 FDDLQFFENCGGGSFGSVYRAKWISQ-----------DKEVAVKKLLKIEKEAEILSVLS 61
Query: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYL 229
H NII V LE PN +V EYA+ G L + R + ++ WA +A+GMHYL
Sbjct: 62 HRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 121
Query: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289
H EA V VIHRDLKS N++ I +D + LKI DFG +R + TT MS GT+ WM
Sbjct: 122 HMEAPVKVIHRDLKSRNVV----IAADGV----LKICDFGASRFHNHTTHMSLVGTFPWM 173
Query: 290 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 349
APEVI++ S+ D +S+GV+LWE+LT EVP++G++ L VA+ V L IPS+CP
Sbjct: 174 APEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPR 233
Query: 350 PFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDE 409
FA+L+ CW D +RP F I+ LE++ +SF + W+ EI+ +
Sbjct: 234 SFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLER 293
Query: 410 LRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLL 461
L+ E++L +E+E L+ RE L WE ++ E+ T LL
Sbjct: 294 LKKLERDLSFKEQE--------------LKERERRLKMWEQKLTEQSNTPLL 331
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 218 bits (556), Expect = 1e-56
Identities = 131/352 (37%), Positives = 192/352 (54%), Gaps = 37/352 (10%)
Query: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE-SVRQEARLFAMLA 172
F +L+ E G G FG VYR W + D++++V + +EA + ++L+
Sbjct: 13 FDDLQFFENCGGGSFGSVYRAKWISQ-----------DKEVAVKKLLKIEKEAEILSVLS 61
Query: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYL 229
H NII V LE PN +V EYA+ G L + R + ++ WA +A+GMHYL
Sbjct: 62 HRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 121
Query: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289
H EA V VIHRDLKS N++ I +D + LKI DFG +R + TT MS GT+ WM
Sbjct: 122 HMEAPVKVIHRDLKSRNVV----IAADGV----LKICDFGASRFHNHTTHMSLVGTFPWM 173
Query: 290 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 349
APEVI++ S+ D +S+GV+LWE+LT EVP++G++ L VA+ V L IPS+CP
Sbjct: 174 APEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPR 233
Query: 350 PFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDE 409
FA+L+ CW D +RP F I+ LE++ +SF + W+ EI+ +
Sbjct: 234 SFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLER 293
Query: 410 LRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLL 461
L+ E++L +E+E L+ RE L WE ++ E+ T LL
Sbjct: 294 LKKLERDLSFKEQE--------------LKERERRLKMWEQKLTEQSNTPLL 331
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 163 bits (412), Expect = 7e-40
Identities = 141/514 (27%), Positives = 233/514 (45%), Gaps = 60/514 (11%)
Query: 110 EVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFA 169
E ++E+ +EEV+G G FG V + WR + VA+K + + + E R +
Sbjct: 29 EEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV------ELRQLS 82
Query: 170 MLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL----VNWAVQIARG 225
+ HPNI+ L CL +CLVMEYA GG L L G P+ ++W +Q ++G
Sbjct: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
Query: 226 MHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT 285
+ YLH +IHRDLK N+LL+ LKI DFG A + +T + G+
Sbjct: 141 VAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QTHMTNNKGS 192
Query: 286 YAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL-PIP 344
AWMAPEV + S +S+ DV+S+G++LWE++T P+ I A AV+ T P+
Sbjct: 193 AAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLI 252
Query: 345 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQ 404
P+P LM CW++DP +RP ++++ + ++R P + +Q + +
Sbjct: 253 KNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRYFP-GADEPLQYPCQYSDE 307
Query: 405 GLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQV 464
G + + + + T + + + EQ+ + + E ++ + + QQ
Sbjct: 308 GQSNSATSTGSFM---DIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAK---QQS 361
Query: 465 DRERPHVRRRRGTFKRSKLRARDGGERISMPL-DFKHRITVQASPGLDRRRNVFEVGPGD 523
+ R + RG+ S L G+R+S + + + RI G RRR++
Sbjct: 362 ESGRLSLGASRGSSVES-LPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSI------- 413
Query: 524 SPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRS 583
+ + + EPGQ R SS+ R GP+S KP +
Sbjct: 414 -------QDLTVTGTEPGQVSSR--------SSSPSVRMITTSGPTSEKPTRSHPW---- 454
Query: 584 RMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPS 617
D++T SD+S P+ + L P P+
Sbjct: 455 TPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPN 488
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 162 bits (411), Expect = 9e-40
Identities = 138/497 (27%), Positives = 228/497 (45%), Gaps = 60/497 (12%)
Query: 110 EVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFA 169
E ++E+ +EEV+G G FG V + WR + VA+K + + + E R +
Sbjct: 29 EEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV------ELRQLS 82
Query: 170 MLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL----VNWAVQIARG 225
+ HPNI+ L CL +CLVMEYA GG L L G P+ ++W +Q ++G
Sbjct: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
Query: 226 MHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT 285
+ YLH +IHRDLK N+LL+ LKI DFG A + +T + G+
Sbjct: 141 VAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QTHMTNNKGS 192
Query: 286 YAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL-PIP 344
AWMAPEV + S +S+ DV+S+G++LWE++T P+ I A AV+ T P+
Sbjct: 193 AAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLI 252
Query: 345 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQ 404
P+P LM CW++DP +RP ++++ + ++R P + +Q + +
Sbjct: 253 KNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRYFP-GADEPLQYPCQYSDE 307
Query: 405 GLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQV 464
G + + + + T + + + EQ+ + + E ++ + + QQ
Sbjct: 308 GQSNSATSTGSFM---DIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAK---QQS 361
Query: 465 DRERPHVRRRRGTFKRSKLRARDGGERISMPL-DFKHRITVQASPGLDRRRNVFEVGPGD 523
+ R + RG+ S L G+R+S + + + RI G RRR++
Sbjct: 362 ESGRLSLGASRGSSVES-LPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSI------- 413
Query: 524 SPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRS 583
+ + + EPGQ R SS+ R GP+S KP +
Sbjct: 414 -------QDLTVTGTEPGQVSSR--------SSSPSVRMITTSGPTSEKPTRSHPW---- 454
Query: 584 RMDEATWYLDSDDSSPL 600
D++T SD+S P+
Sbjct: 455 TPDDSTDTNGSDNSIPM 471
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 160 bits (405), Expect = 5e-39
Identities = 149/531 (28%), Positives = 242/531 (45%), Gaps = 67/531 (12%)
Query: 110 EVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFA 169
E ++E+ +EEV+G G FG V + WR + VA+K + + + E R +
Sbjct: 29 EEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV------ELRQLS 82
Query: 170 MLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL----VNWAVQIARG 225
+ HPNI+ L CL +CLVMEYA GG L L G P+ ++W +Q ++G
Sbjct: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
Query: 226 MHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT 285
+ YLH +IHRDLK N+LL+ LKI DFG A + +T + G+
Sbjct: 141 VAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QTHMTNNKGS 192
Query: 286 YAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL-PIP 344
AWMAPEV + S +S+ DV+S+G++LWE++T P+ I A AV+ T P+
Sbjct: 193 AAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLI 252
Query: 345 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQ 404
P+P LM CW++DP +RP ++++ + ++R P + +Q + +
Sbjct: 253 KNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRYFP-GADEPLQYPCQYSDE 307
Query: 405 GLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQV 464
G + + + + T + + + EQ+ + + E ++ + + QQ
Sbjct: 308 GQSNSATSTGSFM---DIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAK---QQS 361
Query: 465 DRERPHVRRRRGTFKRSKLRARDGGERISMPL-DFKHRI---TVQASPGLDRRR-----N 515
+ R + RG+ S L G+R+S + + + RI T + P R+ N
Sbjct: 362 ESGRLSLGASRGSSVES-LPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
Query: 516 VFEV------GPGDSPTFPRFRAIQ---LEPAEPGQAWGRQSPRRLEDSSNGERRACWAW 566
+ +V G G PR R+IQ + EPGQ R SS+ R
Sbjct: 421 ILDVPEIVISGNGQ----PRRRSIQDLTVTGTEPGQVSSR--------SSSPSVRMITTS 468
Query: 567 GPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPS 617
GP+S KP + D++T SD+S P+ + L P P+
Sbjct: 469 GPTSEKPTRSHPW----TPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPN 515
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 160 bits (404), Expect = 6e-39
Identities = 146/514 (28%), Positives = 237/514 (46%), Gaps = 67/514 (13%)
Query: 110 EVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFA 169
E ++E+ +EEV+G G FG V + WR + VA+K + + + E R +
Sbjct: 29 EEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV------ELRQLS 82
Query: 170 MLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL----VNWAVQIARG 225
+ HPNI+ L CL +CLVMEYA GG L L G P+ ++W +Q ++G
Sbjct: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
Query: 226 MHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT 285
+ YLH +IHRDLK N+LL+ LKI DFG A + +T + G+
Sbjct: 141 VAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QTHMTNNKGS 192
Query: 286 YAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL-PIP 344
AWMAPEV + S +S+ DV+S+G++LWE++T P+ I A AV+ T P+
Sbjct: 193 AAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLI 252
Query: 345 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQ 404
P+P LM CW++DP +RP ++++ + ++R P + +Q + +
Sbjct: 253 KNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRYFP-GADEPLQYPCQYSDE 307
Query: 405 GLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQV 464
G + + + + T + + + EQ+ + + E ++ + + QQ
Sbjct: 308 GQSNSATSTGSFM---DIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAK---QQS 361
Query: 465 DRERPHVRRRRGTFKRSKLRARDGGERISMPL-DFKHRI---TVQASPGLDRRR-----N 515
+ R + RG+ S L G+R+S + + + RI T + P R+ N
Sbjct: 362 ESGRLSLGASRGSSVES-LPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
Query: 516 VFEV------GPGDSPTFPRFRAIQ---LEPAEPGQAWGRQSPRRLEDSSNGERRACWAW 566
+ +V G G PR R+IQ + EPGQ R SS+ R
Sbjct: 421 ILDVPEIVISGNGQ----PRRRSIQDLTVTGTEPGQVSSR--------SSSPSVRMITTS 468
Query: 567 GPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL 600
GP+S KP + D++T SD+S P+
Sbjct: 469 GPTSEKPTRSHPW----TPDDSTDTNGSDNSIPM 498
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 148 bits (374), Expect = 2e-35
Identities = 98/278 (35%), Positives = 139/278 (50%), Gaps = 24/278 (8%)
Query: 111 VASFQELRLEEVIGIGGFGKVYRGSWRGE--LVAVKAARQDPDEDISVTAESVRQEARLF 168
V + ++L L E IG G FG+V+ G R + LVAVK+ R+ D+ QEAR+
Sbjct: 427 VLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA---KFLQEARIL 483
Query: 169 AMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA--GRRVPPHVLVNWAVQIARGM 226
+HPNI+ L VC ++ + +VME GG L G R+ L+ A GM
Sbjct: 484 KQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGM 543
Query: 227 HYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT- 285
YL + IHRDL + N L+ E LKI+DFG++RE ++ G
Sbjct: 544 EYLESKCC---IHRDLAARNCLVT--------EKNVLKISDFGMSREEADGVYAASGGLR 592
Query: 286 ---YAWMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTL 341
W APE + +S SDVWSFG+LLWE + G PY + V L
Sbjct: 593 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RL 651
Query: 342 PIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEAL 379
P P CP+ +LM CWA +P +RP F++I Q+L+++
Sbjct: 652 PCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 689
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 148 bits (374), Expect = 2e-35
Identities = 98/278 (35%), Positives = 139/278 (50%), Gaps = 24/278 (8%)
Query: 111 VASFQELRLEEVIGIGGFGKVYRGSWRGE--LVAVKAARQDPDEDISVTAESVRQEARLF 168
V + ++L L E IG G FG+V+ G R + LVAVK+ R+ D+ QEAR+
Sbjct: 485 VLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA---KFLQEARIL 541
Query: 169 AMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA--GRRVPPHVLVNWAVQIARGM 226
+HPNI+ L VC ++ + +VME GG L G R+ L+ A GM
Sbjct: 542 KQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGM 601
Query: 227 HYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT- 285
YL + IHRDL + N L+ E LKI+DFG++RE ++ G
Sbjct: 602 EYLESKCC---IHRDLAARNCLVT--------EKNVLKISDFGMSREEADGVYAASGGLR 650
Query: 286 ---YAWMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTL 341
W APE + +S SDVWSFG+LLWE + G PY + V L
Sbjct: 651 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RL 709
Query: 342 PIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEAL 379
P P CP+ +LM CWA +P +RP F++I Q+L+++
Sbjct: 710 PCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 747
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 148 bits (374), Expect = 2e-35
Identities = 98/278 (35%), Positives = 139/278 (50%), Gaps = 24/278 (8%)
Query: 111 VASFQELRLEEVIGIGGFGKVYRGSWRGE--LVAVKAARQDPDEDISVTAESVRQEARLF 168
V + ++L L E IG G FG+V+ G R + LVAVK+ R+ D+ QEAR+
Sbjct: 497 VLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA---KFLQEARIL 553
Query: 169 AMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA--GRRVPPHVLVNWAVQIARGM 226
+HPNI+ L VC ++ + +VME GG L G R+ L+ A GM
Sbjct: 554 KQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGM 613
Query: 227 HYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT- 285
YL + IHRDL + N L+ E LKI+DFG++RE ++ G
Sbjct: 614 EYLESKCC---IHRDLAARNCLVT--------EKNVLKISDFGMSREEADGVYAASGGLR 662
Query: 286 ---YAWMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTL 341
W APE + +S SDVWSFG+LLWE + G PY + V L
Sbjct: 663 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RL 721
Query: 342 PIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEAL 379
P P CP+ +LM CWA +P +RP F++I Q+L+++
Sbjct: 722 PCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 759
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 148 bits (374), Expect = 2e-35
Identities = 98/278 (35%), Positives = 139/278 (50%), Gaps = 24/278 (8%)
Query: 111 VASFQELRLEEVIGIGGFGKVYRGSWRGE--LVAVKAARQDPDEDISVTAESVRQEARLF 168
V + ++L L E IG G FG+V+ G R + LVAVK+ R+ D+ QEAR+
Sbjct: 555 VLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA---KFLQEARIL 611
Query: 169 AMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA--GRRVPPHVLVNWAVQIARGM 226
+HPNI+ L VC ++ + +VME GG L G R+ L+ A GM
Sbjct: 612 KQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGM 671
Query: 227 HYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT- 285
YL + IHRDL + N L+ E LKI+DFG++RE ++ G
Sbjct: 672 EYLESKCC---IHRDLAARNCLVT--------EKNVLKISDFGMSREEADGVYAASGGLR 720
Query: 286 ---YAWMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTL 341
W APE + +S SDVWSFG+LLWE + G PY + V L
Sbjct: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RL 779
Query: 342 PIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEAL 379
P P CP+ +LM CWA +P +RP F++I Q+L+++
Sbjct: 780 PCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 817
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 141 bits (355), Expect = 3e-33
Identities = 193/744 (25%), Positives = 286/744 (38%), Gaps = 123/744 (16%)
Query: 116 ELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
++ ++ +G G +G+VY G W+ VAVK ++D E E +EA + + H
Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVMKEIKH 295
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLS---RALAGRRVPPHVLVNWAVQIARGMHYLH 230
PN++ L VC EP ++ E+ G L R + V VL+ A QI+ M YL
Sbjct: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355
Query: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT---YA 287
+ IHRDL + N L+ E+ +K+ DFGL+R T + AG
Sbjct: 356 KKNF---IHRDLAARNCLV--------GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 404
Query: 288 WMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
W APE + + FS SDVW+FGVLLWE+ T G PY GID L+ Y + + P
Sbjct: 405 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEG 463
Query: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLEAL--EAQVLREMPRDSFHSMQEGWKREIQ 404
CPE +LM CW +P RP FA I Q E + E+ + E+ + E K+ ++
Sbjct: 464 CPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEK-------ELGKQGVR 516
Query: 405 GLFDE-LRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERE--LTLLL 461
G L+A E L + +R A E R + + H Q E + + E ++ LL
Sbjct: 517 GAVSTLLQAPE---LPTKTRTSRRAAEHRDTTD-VPEMPHSKGQGESDPLDHEPAVSPLL 572
Query: 462 QQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASP----------GLD 511
+ +R P G + +L +D + L K + T P G
Sbjct: 573 PRKERGPP----EGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQP 628
Query: 512 RRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSP 571
RR E D A+ P + P NG R G SP
Sbjct: 629 ERRGAGEEEGRDISN----GALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSP 684
Query: 572 KPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAER 631
+ + SR+ AT + SS + A P + + E +P +
Sbjct: 685 HLWKKSSTLTSSRL--ATGEEEGGGSSSKRFLRSCSA--SCVPHGAKDTEWRSVTLPRDL 740
Query: 632 GSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPP 691
S+ G +S G + P P + GE+ + T T P
Sbjct: 741 QST-------------GRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTR-----GTVTP 782
Query: 692 PSPLICFSLKTPD-------------SPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGT 738
P L+ + + D SPP P L + V S P +EE +G
Sbjct: 783 PPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASG-LPHKEEAGKGSA 841
Query: 739 VSPPPG------TSRSAPGTPGTPRSPPL-------------------GLISRPRPSPLR 773
+ P TS++ G PG P G +SR +P+P
Sbjct: 842 LGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAP-- 899
Query: 774 SRIDPWSFVSAGPRPSPLPSPQPA 797
S AG +PS PS + A
Sbjct: 900 PPPPAASAGKAGGKPSQSPSQEAA 923
Score = 37.0 bits (84), Expect = 0.077
Identities = 52/230 (22%), Positives = 80/230 (34%), Gaps = 25/230 (10%)
Query: 514 RNVFEVGPGDSPTF----PRFRAIQLEPA-------EPGQAWGRQSPRRLEDSSNGERRA 562
+++ E PG SP P R + + PA E G+ +P E + +
Sbjct: 799 KDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAG 858
Query: 563 CWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEE 622
A G +S P E RR E+ D S L P+ PP PP S
Sbjct: 859 SGAPGGTSKGPAEESRVRRHKHSSESPGR-DKGKLSRL-KPAPPP-----PPAASAGKAG 911
Query: 623 PKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPT-- 680
K P++ S + + A + T+L+ ++ G G ++ P TP
Sbjct: 912 GK---PSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQS 968
Query: 681 --PTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSP 728
P+ P P PS L S P+ + + V R + P
Sbjct: 969 AKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQP 1018
Score = 33.9 bits (76), Expect = 0.65
Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 45 VWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVS 101
++ AL+D+ SG + L++ KG+++ VL + + W Q G PSNY++
Sbjct: 65 LFVALYDFVASGDNTLSITKGEKLRVL----GYNHNGEWCEAQTKNGQGWVPSNYIT 117
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 141 bits (355), Expect = 3e-33
Identities = 193/744 (25%), Positives = 286/744 (38%), Gaps = 123/744 (16%)
Query: 116 ELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
++ ++ +G G +G+VY G W+ VAVK ++D E E +EA + + H
Sbjct: 260 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVMKEIKH 314
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLS---RALAGRRVPPHVLVNWAVQIARGMHYLH 230
PN++ L VC EP ++ E+ G L R + V VL+ A QI+ M YL
Sbjct: 315 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 374
Query: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT---YA 287
+ IHRDL + N L+ E+ +K+ DFGL+R T + AG
Sbjct: 375 KKNF---IHRDLAARNCLV--------GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 423
Query: 288 WMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
W APE + + FS SDVW+FGVLLWE+ T G PY GID L+ Y + + P
Sbjct: 424 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEG 482
Query: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLEAL--EAQVLREMPRDSFHSMQEGWKREIQ 404
CPE +LM CW +P RP FA I Q E + E+ + E+ + E K+ ++
Sbjct: 483 CPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEK-------ELGKQGVR 535
Query: 405 GLFDE-LRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERE--LTLLL 461
G L+A E L + +R A E R + + H Q E + + E ++ LL
Sbjct: 536 GAVSTLLQAPE---LPTKTRTSRRAAEHRDTTD-VPEMPHSKGQGESDPLDHEPAVSPLL 591
Query: 462 QQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASP----------GLD 511
+ +R P G + +L +D + L K + T P G
Sbjct: 592 PRKERGPP----EGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQP 647
Query: 512 RRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSP 571
RR E D A+ P + P NG R G SP
Sbjct: 648 ERRGAGEEEGRDISN----GALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSP 703
Query: 572 KPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAER 631
+ + SR+ AT + SS + A P + + E +P +
Sbjct: 704 HLWKKSSTLTSSRL--ATGEEEGGGSSSKRFLRSCSA--SCVPHGAKDTEWRSVTLPRDL 759
Query: 632 GSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPP 691
S+ G +S G + P P + GE+ + T T P
Sbjct: 760 QST-------------GRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTR-----GTVTP 801
Query: 692 PSPLICFSLKTPD-------------SPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGT 738
P L+ + + D SPP P L + V S P +EE +G
Sbjct: 802 PPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASG-LPHKEEAGKGSA 860
Query: 739 VSPPPG------TSRSAPGTPGTPRSPPL-------------------GLISRPRPSPLR 773
+ P TS++ G PG P G +SR +P+P
Sbjct: 861 LGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAP-- 918
Query: 774 SRIDPWSFVSAGPRPSPLPSPQPA 797
S AG +PS PS + A
Sbjct: 919 PPPPAASAGKAGGKPSQSPSQEAA 942
Score = 37.0 bits (84), Expect = 0.077
Identities = 52/230 (22%), Positives = 80/230 (34%), Gaps = 25/230 (10%)
Query: 514 RNVFEVGPGDSPTF----PRFRAIQLEPA-------EPGQAWGRQSPRRLEDSSNGERRA 562
+++ E PG SP P R + + PA E G+ +P E + +
Sbjct: 818 KDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAG 877
Query: 563 CWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEE 622
A G +S P E RR E+ D S L P+ PP PP S
Sbjct: 878 SGAPGGTSKGPAEESRVRRHKHSSESPGR-DKGKLSRL-KPAPPP-----PPAASAGKAG 930
Query: 623 PKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPT-- 680
K P++ S + + A + T+L+ ++ G G ++ P TP
Sbjct: 931 GK---PSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQS 987
Query: 681 --PTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSP 728
P+ P P PS L S P+ + + V R + P
Sbjct: 988 AKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQP 1037
Score = 33.9 bits (76), Expect = 0.65
Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 45 VWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVS 101
++ AL+D+ SG + L++ KG+++ VL + + W Q G PSNY++
Sbjct: 84 LFVALYDFVASGDNTLSITKGEKLRVL----GYNHNGEWCEAQTKNGQGWVPSNYIT 136
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 140 bits (352), Expect = 6e-33
Identities = 94/272 (34%), Positives = 138/272 (50%), Gaps = 28/272 (10%)
Query: 117 LRLEEVIGIGGFGKVYRGSWRGEL-VAVKAARQDPDEDISVTAESVRQEARLFAMLAHPN 175
++L + +G G FG+V+ G W VAVK + S+ +EA++ L HP
Sbjct: 234 IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPG-----SMDPNDFLREAQIMKNLRHPK 288
Query: 176 IIALKAVCLEEPNLCLVMEYAAGGPLSRAL---AGRRVPPHVLVNWAVQIARGMHYLHCE 232
+I L AVC E + ++ E G L L G ++ V+ A Q+A GM YL
Sbjct: 289 LIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESR 348
Query: 233 ALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYA----- 287
IHRDL + N+L+ EH K+ DFGLAR + + +
Sbjct: 349 NY---IHRDLAARNVLV--------GEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPV 397
Query: 288 -WMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPS 345
W APE I+++ FS SDVWSFG+LL+E++T G++PY G+ V +A N LP PS
Sbjct: 398 KWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN-YRLPQPS 456
Query: 346 TCPEPFAQLMADCWAQDPHRRPDFASILQQLE 377
CP+ F +M +CW +P RP F ++ +LE
Sbjct: 457 NCPQQFYNIMLECWNAEPKERPTFETLRWKLE 488
Score = 37.0 bits (84), Expect = 0.077
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)
Query: 46 WTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWW---------AGQVGGQVGIFP 96
+ ALFDY+ ++L+ R GD+++VL + EGWW G G P
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLD-----TLHEGWWFARHLEKRRDGSSQQLQGYIP 101
Query: 97 SNYVS 101
SNYV+
Sbjct: 102 SNYVA 106
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 139 bits (349), Expect = 1e-32
Identities = 89/271 (32%), Positives = 140/271 (51%), Gaps = 21/271 (7%)
Query: 116 ELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPN 175
E+ E+IG G FGKVY+G R ++VA+K R + S + +E + L HP
Sbjct: 462 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS-DVDMFCREVSILCQLNHPC 520
Query: 176 IIALKAVCLEEPN-LCLVMEYAAGGPLSRALAGRR----VPPHVLVNWAVQIARGMHYLH 230
+I CL +P+ +V +Y +GG L L ++ + +++ AV +A+GM YLH
Sbjct: 521 VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII--AVDVAKGMEYLH 578
Query: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR---EWHKTTQMSAAGTYA 287
P+IHRDL S+NILL E + DFG +R + G
Sbjct: 579 -NLTQPIIHRDLNSHNILLY--------EDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 629
Query: 288 WMAPEVIKAST-FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
WMAPEV T ++ +DV+S+ + LWE+LTGE+P+ + A A +A + + PI +
Sbjct: 630 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 689
Query: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLE 377
P+P + L+ W P RP+F+ ++ +LE
Sbjct: 690 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 139 bits (349), Expect = 1e-32
Identities = 89/271 (32%), Positives = 140/271 (51%), Gaps = 21/271 (7%)
Query: 116 ELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPN 175
E+ E+IG G FGKVY+G R ++VA+K R + S + +E + L HP
Sbjct: 563 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS-DVDMFCREVSILCQLNHPC 621
Query: 176 IIALKAVCLEEPN-LCLVMEYAAGGPLSRALAGRR----VPPHVLVNWAVQIARGMHYLH 230
+I CL +P+ +V +Y +GG L L ++ + +++ AV +A+GM YLH
Sbjct: 622 VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII--AVDVAKGMEYLH 679
Query: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR---EWHKTTQMSAAGTYA 287
P+IHRDL S+NILL E + DFG +R + G
Sbjct: 680 -NLTQPIIHRDLNSHNILLY--------EDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 730
Query: 288 WMAPEVIKAST-FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
WMAPEV T ++ +DV+S+ + LWE+LTGE+P+ + A A +A + + PI +
Sbjct: 731 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 790
Query: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLE 377
P+P + L+ W P RP+F+ ++ +LE
Sbjct: 791 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 138 bits (347), Expect = 2e-32
Identities = 105/321 (32%), Positives = 152/321 (47%), Gaps = 32/321 (9%)
Query: 116 ELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
++ ++ +G G +G+VY G W+ VAVK ++D E E +EA + + H
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVMKEIKH 326
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLS---RALAGRRVPPHVLVNWAVQIARGMHYLH 230
PN++ L VC EP +V EY G L R V VL+ A QI+ M YL
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
Query: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT---YA 287
+ IHRDL + N L+ E+ +K+ DFGL+R T + AG
Sbjct: 387 KKNF---IHRDLAARNCLV--------GENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK 435
Query: 288 WMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
W APE + +TFS SDVW+FGVLLWE+ T G PY GID L+ Y + + P
Sbjct: 436 WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEG 494
Query: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLE------ALEAQVLREMPRDSFHSMQEGWK 400
CP +LM CW P RP FA Q E ++ +V E+ R + S +
Sbjct: 495 CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYL 554
Query: 401 REIQGLFDELRAKEKELLSRE 421
+ L + R +K++ ++E
Sbjct: 555 PRLPILPSKTRTLKKQVENKE 575
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 8/59 (13%)
Query: 45 VWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWA--GQVGGQVGIFPSNYVS 101
++ AL+D+ SG + L++ KG+++ VL + G W+ GQ G PSNY++
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYN-----QNGEWSEVRSKNGQ-GWVPSNYIT 148
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 138 bits (347), Expect = 2e-32
Identities = 105/321 (32%), Positives = 152/321 (47%), Gaps = 32/321 (9%)
Query: 116 ELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
++ ++ +G G +G+VY G W+ VAVK ++D E E +EA + + H
Sbjct: 287 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVMKEIKH 341
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLS---RALAGRRVPPHVLVNWAVQIARGMHYLH 230
PN++ L VC EP +V EY G L R V VL+ A QI+ M YL
Sbjct: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
Query: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT---YA 287
+ IHRDL + N L+ E+ +K+ DFGL+R T + AG
Sbjct: 402 KKNF---IHRDLAARNCLV--------GENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK 450
Query: 288 WMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
W APE + +TFS SDVW+FGVLLWE+ T G PY GID L+ Y + + P
Sbjct: 451 WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEG 509
Query: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLE------ALEAQVLREMPRDSFHSMQEGWK 400
CP +LM CW P RP FA Q E ++ +V E+ R + S +
Sbjct: 510 CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYL 569
Query: 401 REIQGLFDELRAKEKELLSRE 421
+ L + R +K++ ++E
Sbjct: 570 PRLPILPSKTRTLKKQVENKE 590
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 8/59 (13%)
Query: 45 VWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWA--GQVGGQVGIFPSNYVS 101
++ AL+D+ SG + L++ KG+++ VL + G W+ GQ G PSNY++
Sbjct: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYN-----QNGEWSEVRSKNGQ-GWVPSNYIT 163
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 138 bits (347), Expect = 2e-32
Identities = 105/321 (32%), Positives = 152/321 (47%), Gaps = 32/321 (9%)
Query: 116 ELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
++ ++ +G G +G+VY G W+ VAVK ++D E E +EA + + H
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVMKEIKH 326
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLS---RALAGRRVPPHVLVNWAVQIARGMHYLH 230
PN++ L VC EP +V EY G L R V VL+ A QI+ M YL
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
Query: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT---YA 287
+ IHRDL + N L+ E+ +K+ DFGL+R T + AG
Sbjct: 387 KKNF---IHRDLAARNCLV--------GENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK 435
Query: 288 WMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
W APE + +TFS SDVW+FGVLLWE+ T G PY GID L+ Y + + P
Sbjct: 436 WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEG 494
Query: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLE------ALEAQVLREMPRDSFHSMQEGWK 400
CP +LM CW P RP FA Q E ++ +V E+ R + S +
Sbjct: 495 CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYL 554
Query: 401 REIQGLFDELRAKEKELLSRE 421
+ L + R +K++ ++E
Sbjct: 555 PRLPILPSKTRTLKKQVENKE 575
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 8/59 (13%)
Query: 45 VWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWA--GQVGGQVGIFPSNYVS 101
++ AL+D+ SG + L++ KG+++ VL + G W+ GQ G PSNY++
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYN-----QNGEWSEVRSKNGQ-GWVPSNYIT 148
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 138 bits (347), Expect = 2e-32
Identities = 105/321 (32%), Positives = 152/321 (47%), Gaps = 32/321 (9%)
Query: 116 ELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
++ ++ +G G +G+VY G W+ VAVK ++D E E +EA + + H
Sbjct: 251 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVMKEIKH 305
Query: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLS---RALAGRRVPPHVLVNWAVQIARGMHYLH 230
PN++ L VC EP +V EY G L R V VL+ A QI+ M YL
Sbjct: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365
Query: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT---YA 287
+ IHRDL + N L+ E+ +K+ DFGL+R T + AG
Sbjct: 366 KKNF---IHRDLAARNCLV--------GENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK 414
Query: 288 WMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
W APE + +TFS SDVW+FGVLLWE+ T G PY GID L+ Y + + P
Sbjct: 415 WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEG 473
Query: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLE------ALEAQVLREMPRDSFHSMQEGWK 400
CP +LM CW P RP FA Q E ++ +V E+ R + S +
Sbjct: 474 CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYL 533
Query: 401 REIQGLFDELRAKEKELLSRE 421
+ L + R +K++ ++E
Sbjct: 534 PRLPILPSKTRTLKKQVENKE 554
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 8/59 (13%)
Query: 45 VWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWA--GQVGGQVGIFPSNYVS 101
++ AL+D+ SG + L++ KG+++ VL + G W+ GQ G PSNY++
Sbjct: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYN-----QNGEWSEVRSKNGQ-GWVPSNYIT 127
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 138 bits (347), Expect = 2e-32
Identities = 97/268 (36%), Positives = 136/268 (50%), Gaps = 24/268 (8%)
Query: 113 SFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLA 172
+ Q L L IG G FG V +G + G+ VAVK + D VTA++ E + +
Sbjct: 190 NLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCD------VTAQAFLDETAVMTKMQ 243
Query: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYL 229
H N++ L V L + L +VME+ + G L L R V L+ +++ +A GM YL
Sbjct: 244 HENLVRLLGVILHQ-GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYL 302
Query: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289
+ LV HRDL + NIL+ S+D+ K++DFGLA+ K S W
Sbjct: 303 ESKKLV---HRDLAARNILV-----SEDL---VAKVSDFGLAKAERKGLDSSRLPV-KWT 350
Query: 290 APEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP 348
APE +K F+ SDVWSFGVLLWE+ + G PY + V+ V P P CP
Sbjct: 351 APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCP 409
Query: 349 EPFAQLMADCWAQDPHRRPDFASILQQL 376
P LM+ CW +P RRP F + ++L
Sbjct: 410 GPVHVLMSSCWEAEPARRPPFRKLAEKL 437
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 138 bits (347), Expect = 2e-32
Identities = 97/268 (36%), Positives = 136/268 (50%), Gaps = 24/268 (8%)
Query: 113 SFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLA 172
+ Q L L IG G FG V +G + G+ VAVK + D VTA++ E + +
Sbjct: 232 NLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCD------VTAQAFLDETAVMTKMQ 285
Query: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYL 229
H N++ L V L + L +VME+ + G L L R V L+ +++ +A GM YL
Sbjct: 286 HENLVRLLGVILHQ-GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYL 344
Query: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289
+ LV HRDL + NIL+ S+D+ K++DFGLA+ K S W
Sbjct: 345 ESKKLV---HRDLAARNILV-----SEDL---VAKVSDFGLAKAERKGLDSSRLPV-KWT 392
Query: 290 APEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP 348
APE +K F+ SDVWSFGVLLWE+ + G PY + V+ V P P CP
Sbjct: 393 APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCP 451
Query: 349 EPFAQLMADCWAQDPHRRPDFASILQQL 376
P LM+ CW +P RRP F + ++L
Sbjct: 452 GPVHVLMSSCWEAEPARRPPFRKLAEKL 479
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 138 bits (347), Expect = 2e-32
Identities = 97/268 (36%), Positives = 136/268 (50%), Gaps = 24/268 (8%)
Query: 113 SFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLA 172
+ Q L L IG G FG V +G + G+ VAVK + D VTA++ E + +
Sbjct: 231 NLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCD------VTAQAFLDETAVMTKMQ 284
Query: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYL 229
H N++ L V L + L +VME+ + G L L R V L+ +++ +A GM YL
Sbjct: 285 HENLVRLLGVILHQ-GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYL 343
Query: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289
+ LV HRDL + NIL+ S+D+ K++DFGLA+ K S W
Sbjct: 344 ESKKLV---HRDLAARNILV-----SEDL---VAKVSDFGLAKAERKGLDSSRLPV-KWT 391
Query: 290 APEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP 348
APE +K F+ SDVWSFGVLLWE+ + G PY + V+ V P P CP
Sbjct: 392 APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCP 450
Query: 349 EPFAQLMADCWAQDPHRRPDFASILQQL 376
P LM+ CW +P RRP F + ++L
Sbjct: 451 GPVHVLMSSCWEAEPARRPPFRKLAEKL 478
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 137 bits (345), Expect = 4e-32
Identities = 95/277 (34%), Positives = 135/277 (48%), Gaps = 24/277 (8%)
Query: 113 SFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLA 172
+ +EL+L + IG G FG V G +RG VAVK + D TA++ EA + L
Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND------ATAQAFLAEASVMTQLR 244
Query: 173 HPNIIALKAVCLEEPN-LCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHY 228
H N++ L V +EE L +V EY A G L L R + L+ +++ + M Y
Sbjct: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304
Query: 229 LHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAW 288
L V HRDL + N+L+ E K++DFGL +E +TQ + W
Sbjct: 305 LEGNNFV---HRDLAARNVLV--------SEDNVAKVSDFGLTKE-ASSTQDTGKLPVKW 352
Query: 289 MAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPSTC 347
APE ++ FS SDVWSFG+LLWE+ + G VPY I V V + P C
Sbjct: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGC 411
Query: 348 PEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVL 384
P ++M +CW D RP F + +QLE ++ L
Sbjct: 412 PPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHEL 448
Score = 30.8 bits (68), Expect = 5.5
Identities = 17/59 (28%), Positives = 32/59 (54%), Gaps = 5/59 (8%)
Query: 48 ALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWW-AGQVGGQVGIFPSNYVSRGGG 105
A +++ + + +L KGD + ++ A++ D W+ A G+ GI P+NYV + G
Sbjct: 16 AKYNFHGTAEQDLPFCKGDVLTIV----AVTKDPNWYKAKNKVGREGIIPANYVQKREG 70
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 137 bits (345), Expect = 4e-32
Identities = 95/277 (34%), Positives = 135/277 (48%), Gaps = 24/277 (8%)
Query: 113 SFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLA 172
+ +EL+L + IG G FG V G +RG VAVK + D TA++ EA + L
Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND------ATAQAFLAEASVMTQLR 244
Query: 173 HPNIIALKAVCLEEPN-LCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHY 228
H N++ L V +EE L +V EY A G L L R + L+ +++ + M Y
Sbjct: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304
Query: 229 LHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAW 288
L V HRDL + N+L+ E K++DFGL +E +TQ + W
Sbjct: 305 LEGNNFV---HRDLAARNVLV--------SEDNVAKVSDFGLTKE-ASSTQDTGKLPVKW 352
Query: 289 MAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPSTC 347
APE ++ FS SDVWSFG+LLWE+ + G VPY I V V + P C
Sbjct: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGC 411
Query: 348 PEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVL 384
P ++M +CW D RP F + +QLE ++ L
Sbjct: 412 PPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHEL 448
Score = 30.8 bits (68), Expect = 5.5
Identities = 17/59 (28%), Positives = 32/59 (54%), Gaps = 5/59 (8%)
Query: 48 ALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWW-AGQVGGQVGIFPSNYVSRGGG 105
A +++ + + +L KGD + ++ A++ D W+ A G+ GI P+NYV + G
Sbjct: 16 AKYNFHGTAEQDLPFCKGDVLTIV----AVTKDPNWYKAKNKVGREGIIPANYVQKREG 70
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.136 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,752,696
Number of Sequences: 37866
Number of extensions: 3115443
Number of successful extensions: 52968
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1105
Number of HSP's successfully gapped in prelim test: 2209
Number of HSP's that attempted gapping in prelim test: 23235
Number of HSP's gapped (non-prelim): 17808
length of query: 847
length of database: 18,247,518
effective HSP length: 111
effective length of query: 736
effective length of database: 14,044,392
effective search space: 10336672512
effective search space used: 10336672512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.