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Search of human proteins with 4505129
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505129 mutated in colorectal cancers isoform 2 [Homo
sapiens]
(829 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505129 mutated in colorectal cancers isoform 2 [Homo sapiens] 1586 0.0
gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens] 1550 0.0
gi|31543140 Usher syndrome 1C binding protein 1 [Homo sapiens] 161 3e-39
gi|21735548 centrosomal protein 2 [Homo sapiens] 96 1e-19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 95 2e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 94 7e-19
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 90 1e-17
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 87 8e-17
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 85 3e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 85 3e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 85 3e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 85 3e-16
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 84 4e-16
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 84 5e-16
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 84 7e-16
gi|55770834 centromere protein F [Homo sapiens] 82 2e-15
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 82 3e-15
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 82 3e-15
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 82 3e-15
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 81 5e-15
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 81 5e-15
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 80 8e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 79 1e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 79 2e-14
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 79 2e-14
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 77 9e-14
gi|16262452 cingulin [Homo sapiens] 76 1e-13
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 76 1e-13
gi|58530840 desmoplakin isoform I [Homo sapiens] 76 1e-13
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 76 1e-13
>gi|4505129 mutated in colorectal cancers isoform 2 [Homo sapiens]
Length = 829
Score = 1586 bits (4106), Expect = 0.0
Identities = 829/829 (100%), Positives = 829/829 (100%)
Query: 1 MNSGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQ 60
MNSGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQ
Sbjct: 1 MNSGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQ 60
Query: 61 SHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQS 120
SHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQS
Sbjct: 61 SHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQS 120
Query: 121 QHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSS 180
QHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSS
Sbjct: 121 QHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSS 180
Query: 181 CSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLRE 240
CSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLRE
Sbjct: 181 CSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLRE 240
Query: 241 ENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTS 300
ENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTS
Sbjct: 241 ENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTS 300
Query: 301 TNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSV 360
TNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSV
Sbjct: 301 TNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSV 360
Query: 361 AEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTIT 420
AEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTIT
Sbjct: 361 AEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTIT 420
Query: 421 LEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAA 480
LEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAA
Sbjct: 421 LEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAA 480
Query: 481 GVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWES 540
GVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWES
Sbjct: 481 GVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWES 540
Query: 541 LSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSY 600
LSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSY
Sbjct: 541 LSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSY 600
Query: 601 DVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY 660
DVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY
Sbjct: 601 DVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY 660
Query: 661 LVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELA 720
LVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELA
Sbjct: 661 LVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELA 720
Query: 721 AEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAK 780
AEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAK
Sbjct: 721 AEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAK 780
Query: 781 KKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 829
KKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL
Sbjct: 781 KKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 829
>gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens]
Length = 1019
Score = 1550 bits (4012), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 20 LHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYE 79
LHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYE
Sbjct: 210 LHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYE 269
Query: 80 ERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS 139
ERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS
Sbjct: 270 ERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS 329
Query: 140 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS 199
IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS
Sbjct: 330 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS 389
Query: 200 EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRT 259
EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRT
Sbjct: 390 EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRT 449
Query: 260 KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSN 319
KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSN
Sbjct: 450 KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSN 509
Query: 320 DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 379
DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ
Sbjct: 510 DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 569
Query: 380 TLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYE 439
TLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYE
Sbjct: 570 TLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYE 629
Query: 440 SNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQML 499
SNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQML
Sbjct: 630 SNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQML 689
Query: 500 KRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDT 559
KRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDT
Sbjct: 690 KRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDT 749
Query: 560 EFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLM 619
EFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLM
Sbjct: 750 EFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLM 809
Query: 620 QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM 679
QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM
Sbjct: 810 QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM 869
Query: 680 RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE 739
RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE
Sbjct: 870 RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE 929
Query: 740 LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVE 799
LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVE
Sbjct: 930 LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVE 989
Query: 800 RHETQVRMLKQRIALLEEENSRPHTNETSL 829
RHETQVRMLKQRIALLEEENSRPHTNETSL
Sbjct: 990 RHETQVRMLKQRIALLEEENSRPHTNETSL 1019
Score = 35.8 bits (81), Expect = 0.17
Identities = 24/108 (22%), Positives = 50/108 (46%)
Query: 611 LDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSE 670
L+L N + L ++K ++ EL +L E+E+ LE KL+ + ++ + E ++
Sbjct: 204 LELANTLHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQER 263
Query: 671 VEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENE 718
+ E+R+ L S + K + +ELR+ S+++
Sbjct: 264 TTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQ 311
>gi|31543140 Usher syndrome 1C binding protein 1 [Homo sapiens]
Length = 703
Score = 161 bits (407), Expect = 3e-39
Identities = 161/595 (27%), Positives = 261/595 (43%), Gaps = 101/595 (16%)
Query: 232 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATG 291
++E A L E N L L S+E+EL RT+A++ AIR E++ L++ V+ELQ L ++
Sbjct: 170 QREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDSLLRLE--- 226
Query: 292 PSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI 351
P S N+ +G S SS +DR ++
Sbjct: 227 ---PCPHLSHNQAGGSGSG--------------------------SSSSEADREPWETQD 257
Query: 352 SSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLK 411
S S+A L L+ S+ Q L S + ++ E + E+L IE LK
Sbjct: 258 SF-----SLAHPLLRRLRSHSSTQ----ILGSLPNQPLSPEMHIMEAQMEQLRGSIEKLK 308
Query: 412 SQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQS 471
N LL+ L+ K E +SM +G+ E+ ATAL LALQYSE C EAY +LLAL E++
Sbjct: 309 CFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQYSEHCEEAYRVLLALREAD-- 366
Query: 472 LILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVA 531
S GD++ ++ + AE A LL + + + A
Sbjct: 367 ------------SGAGDEAPMSDL-----------QAAEKEAWRLLAQEEAAMD-----A 398
Query: 532 GCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELE 591
G P S SS D +E +L+ Y+Q+L+ R+ +K+ L
Sbjct: 399 GAQQNP-----------QPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKI--LSEP 445
Query: 592 SIHIDPLSYDVKPRGDSQRL----------DLENAVLMQELMAMKEEMAELKAQLYLLEK 641
+ P+ + Q + LE + Q+L+A +E +A+L +L L+ +
Sbjct: 446 GPTLAPMPTVPRAEAMVQAILGTQAGPALPRLEKTQIQQDLVAAREALADLMLRLQLVRR 505
Query: 642 EKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKE----- 696
EK+ LEL+ + A A+++ +E L+ E E + S SSG +E
Sbjct: 506 EKRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQG 565
Query: 697 --CADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIR 754
+ + ++ +LA E ++ R L+ ++Q L LE++ + R
Sbjct: 566 LPAVPGGTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRAR 625
Query: 755 HQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 809
QSAE DL +A+S LV A+ A +K + + +KLE QM M + +V +L+
Sbjct: 626 RSQSAELNRDLCKAHSALVLAFRGAHRKQEEQRRKLEQQMALMEAQQAEEVAVLE 680
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 95.9 bits (237), Expect = 1e-19
Identities = 200/924 (21%), Positives = 359/924 (38%), Gaps = 155/924 (16%)
Query: 27 SLKGDIVELNKRLQQTERERDLLEK-------KLAKAQCEQSHLMREHEDVQ---ERTTL 76
+L G V+L + +ER+LL+K +L + E L R + ++Q +
Sbjct: 446 TLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQG 505
Query: 77 RYEERITELHSVIAELNKKIDRLQG------------TTIREEDEYSELRSE-LSQSQHE 123
+ EE+ ELH + E + + L G T+RE E S L E L Q Q E
Sbjct: 506 QKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTE 565
Query: 124 VNEDSRSMDQDQTSVSIPENQSTMVTADMD----NCSDLNSELQRVLTGL---------- 169
V +Q +S EN AD+ S LN L GL
Sbjct: 566 VTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE 625
Query: 170 ENVVCGR------KKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN 223
VC R +++ + +AE ++ E L + H + ++ EE L DL +
Sbjct: 626 NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADL-RD 684
Query: 224 LAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTR 283
+ EE+ +K+L+ R + E+ T L +E R + + +E++ L R L+ R
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVR 744
Query: 284 LQSV---------QATGPSSPGRLTST--------NRPINPSTGELSTSSSS-------- 318
LQ+V Q G SS L + N I + G+L +
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
Query: 319 -NDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEI 377
++ K+ + S+ E ++ R + +E G ++ + AH ++ + ++E
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAE--QEGKTALEQQKAAHE-KEVNQLREK 861
Query: 378 FQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAER--MSMLV 435
++ S + E E L R++ +++ + + EE ++ AE M +
Sbjct: 862 WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL 921
Query: 436 GKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENI 495
+ + L LQ ++ +A + L L + + L + G+ + ++ E
Sbjct: 922 ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981
Query: 496 TQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTAS 555
+ D E ++ L K+D + E L S S
Sbjct: 982 EAARQHRDDLAALQEESSSLLQDKMD------------LQKQVEDLKSQLVAQDDSQRLV 1029
Query: 556 SCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLEN 615
+ + + Q ++L+ ++A++ L+++E E + V DS R E
Sbjct: 1030 EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL------VLQEADSIR-QQEL 1082
Query: 616 AVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQ--EQAYLVHI--EHLKSEV 671
+ L Q++ + E EL AQ+ LL +E K E +EAQ E+ HI + L++ +
Sbjct: 1083 SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
Query: 672 EEQK------EQRMRSLSS--TSSGSKDKPGKEC---ADAASPALSLAE-LRTTC-SENE 718
Q+ + R+RS S + ++ +PG + A AS +L + L + C S E
Sbjct: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPE 1202
Query: 719 LAAEFTNA----------------IRREKKLKARVQELV-SALER----LTKSSEIRH-- 755
L+ +A +R L A E V SAL + L K+ + R
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262
Query: 756 ----QQSAEFVNDLKRANSNL----------VAAYEKAKKKHQNKLKKLESQMMAMVERH 801
Q+ E + D + S + ++ ++ K K + K LES++M E H
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM---ELH 1319
Query: 802 ET----QVRMLKQRIALLEEENSR 821
ET Q R+ + + +E + R
Sbjct: 1320 ETMASLQSRLRRAELQRMEAQGER 1343
Score = 82.4 bits (202), Expect = 2e-15
Identities = 183/876 (20%), Positives = 358/876 (40%), Gaps = 122/876 (13%)
Query: 8 KYGNDSSAELSELHSAALASLKGDIVELNKRL--QQTERERDLLEKKLAKAQCEQSHLMR 65
K+ + S EL + AL SL+ + +EL RL QQTE E +++ + Q E +
Sbjct: 861 KWEKERSWHQQEL-AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
Query: 66 EHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTT----IREEDEYSELRSELSQSQ 121
+ E +ER +L E + + +A+ +++++RL+ ++E++ L+++L ++Q
Sbjct: 920 QLETEKERVSLL--ETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977
Query: 122 HEVNEDSRSMDQDQTSVSIPENQSTMVTADMD---NCSDLNSEL-----QRVLTGLENVV 173
E+ E +R D ++ E S+++ MD DL S+L + L E
Sbjct: 978 RELKEAARQHRDDLAALQ--EESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE 1035
Query: 174 CGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYP--NLAEERSRW 231
R+ + E++R LT + + + ++E + + ++L +E
Sbjct: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095
Query: 232 EKELAG----LREENESLTAMLCSKE----EELNRTKATMNAIREERDRLRRRVRELQTR 283
+KEL+ LR+E + A ++E EEL + T +R + +LQ R
Sbjct: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR 1155
Query: 284 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 343
L+S + S L + +P N + + +S + + A + + S S
Sbjct: 1156 LRSTE----SQLEALAAEQQPGNQAQAQAQLASLYSALQQA-LGSVCESRPELSGGGDSA 1210
Query: 344 RPVLGSEISSIGVSS--------------SVAEHLAHSLQDCSNIQEIFQTLYSHGSAIS 389
V G E G S +VA L QD Q+ L +
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLE 1270
Query: 390 ESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLAL 449
E ++ + E E ++++ ++ L+ Q N E S GK S + L
Sbjct: 1271 E-RLTDTEAEKSQVHTELQDLQRQ----------LSQNQEEKSKWEGKQNSLESEL---- 1315
Query: 450 QYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLK--RAHDCRK 507
+E +E + +L + L + A G Q+ EN+T ++ +A
Sbjct: 1316 ------MELHETMASLQSRLRRAELQRMEAQGERELL--QAAKENLTAQVEHLQAAVVEA 1367
Query: 508 TAENAAKALL----------MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSC 557
A+ +A +L +KL + ++Q L + + A
Sbjct: 1368 RAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLT 1427
Query: 558 DTEFTKEDE-QRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENA 616
T +E+E + L+ IQ+L+ R E++ ++ LS D+K R +Q +DL+
Sbjct: 1428 QTLAEREEEVETLRGQIQELEKQR--------EMQKAALELLSLDLKKR--NQEVDLQQE 1477
Query: 617 VLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH--IEHLKSEVEEQ 674
+ QEL + + L + + E+E+K + RE ++ +EH E+E+
Sbjct: 1478 QI-QELEKCRSVLEHLP--MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK- 1533
Query: 675 KEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLK 734
K+Q + S + D ++L L EN E + +E + +
Sbjct: 1534 KDQMIESQRG-----------QVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQ 1582
Query: 735 ARVQELVSALERLTKSSEIRHQQ---SAEFVNDLKRANSNLVAAYE------KAKKKHQN 785
Q + AL LT E R Q+ + ++DL+ ++ L + K++++
Sbjct: 1583 RETQRV--ALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640
Query: 786 KLKKLESQMMAMVERHETQVRMLKQRIALLEEENSR 821
+L++ + + +ER + ++ + K+RI +LE++ +R
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676
Score = 77.8 bits (190), Expect = 4e-14
Identities = 156/810 (19%), Positives = 322/810 (39%), Gaps = 113/810 (13%)
Query: 35 LNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQE-RTTLRYEERITE-----LHSV 88
L +RLQ+ ERD L + Q E L +E E +Q+ R LR + + E L V
Sbjct: 433 LRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV 492
Query: 89 IAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMV 148
EL + D QG ++E++ EL + + + + E ++ Q+ E+ S ++
Sbjct: 493 NVELQLQGDSAQG---QKEEQQEELHLAVRERER-LQEMLMGLEAKQS-----ESLSELI 543
Query: 149 TA-DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIK 207
T + S L EL R ++++ + ++A ++ I +L+++ +
Sbjct: 544 TLREALESSHLEGELLR-----------QEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 208 TVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIR 267
+ L L LA ++ ++L L EEN+S+ + + + E+ N + +
Sbjct: 593 DLRAAAVKLSA-LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAE 651
Query: 268 EERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIA 327
+ R+ L + L+ +LQ + G L +LS S + ++
Sbjct: 652 KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE 711
Query: 328 ERVKLSKTRSE---SSSSDRPVLGSEISSIGVSSSVAEH----LAHSLQDCSNIQEIFQT 380
+ + +K + E + ++ L E +++ V E LA LQ S+ +E+ ++
Sbjct: 712 QLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLES 771
Query: 381 LYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYES 440
E ++ NS IE K Q ++ T+ + K ++ G+
Sbjct: 772 SL---------------FEAQQQNSVIEVTKGQLEVQIQTVTQAKE------VIQGEVRC 810
Query: 441 NATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLK 500
L +EQ +A LA AE E L Q +AA ++ + Q+ +
Sbjct: 811 LKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH----------EKEVNQLRE 860
Query: 501 RAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE 560
+ R + L L+ E++ + T + ++ C +
Sbjct: 861 KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQ 920
Query: 561 FTKEDEQ------------RLKDYIQQLKNDRAAVKLTMLELESI------HIDPLSYDV 602
E E+ L D QQL+ R +K+ L+ + + ++
Sbjct: 921 LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQREL 980
Query: 603 KPRGDSQRLDL-----ENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQE 657
K R DL E++ L+Q+ M +++++ +LK+QL + ++ +E ++ + +
Sbjct: 981 KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET 1040
Query: 658 QAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSEN 717
Q Y ++ E+E +K SL +K + + ++ EL +
Sbjct: 1041 QEY----NRIQKELEREKASLTLSL-------MEKEQRLLVLQEADSIRQQEL------S 1083
Query: 718 ELAAEFTNAIRREKKLKARVQELVSALER-----LTKSSEIRHQQSAEFVNDLKRANSNL 772
L + A +K+L A+++ L ++ L + +++ + A + + ++ ++L
Sbjct: 1084 ALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE-QQLRASL 1142
Query: 773 VAAYEKAKKKHQNKLKKLESQMMAMVERHE 802
A KA + Q +L+ ESQ+ A+ +
Sbjct: 1143 WAQEAKAAQL-QLRLRSTESQLEALAAEQQ 1171
Score = 72.8 bits (177), Expect = 1e-12
Identities = 186/930 (20%), Positives = 357/930 (38%), Gaps = 141/930 (15%)
Query: 11 NDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDV 70
N S E A +L+ D+ E KR + + LE +L KA+ + L + D+
Sbjct: 626 NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685
Query: 71 QE----------RTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQS 120
QE + + E T+L + E K+ + + ++E++ ++ L
Sbjct: 686 QEEKEEIQKKLSESRHQQEAATTQLEQLHQEA-KRQEEVLARAVQEKEALVREKAALEVR 744
Query: 121 QHEVNEDSRSMDQDQTSVSIPEN--QSTMVTADMDNC------SDLNSELQRVLTGLE-- 170
V D + + + +S + +S++ A N L ++Q V E
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
Query: 171 --NVVCGRKKSSCSLSVAEVDRH--IEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAE 226
V C + + S AE +R QL A + A++ + L +
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEK 864
Query: 227 ERSRWEKELA---------------GLREENESLTAMLCSKEEELNRTKATMNAIREERD 271
ERS ++ELA L+E+ + A+ +EEE RT+A + + +
Sbjct: 865 ERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEE--RTQAESALCQMQLE 922
Query: 272 RLRRRVRELQTRLQSVQATGPSSP--GRLTSTNR----PINPSTGELST--SSSSNDIPI 323
+ RV L+T LQ+ + +S RL + +TG L T + ++
Sbjct: 923 TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE 982
Query: 324 AKIAERVKLSKTRSESSS--SDRPVLGSEISSIG------------VSSSVAEHLAHSLQ 369
A R L+ + ESSS D+ L ++ + V V E L + Q
Sbjct: 983 AARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET-Q 1041
Query: 370 DCSNIQEIFQ-----------------TLYSHGSAISESKIREFEVETERLNSRIEHLKS 412
+ + IQ+ + + +I + ++ + + + L +
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101
Query: 413 QNDLLTITLEECKSN--AERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ 470
Q +LL ++E +++ A+ +L S+ T +L Q +A +L L L +E
Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE- 1160
Query: 471 SLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAV 530
Q A PG+Q+ L + + A + +L G GG A
Sbjct: 1161 ----SQLEALAAEQQPGNQA---QAQAQLASLYSALQQALGSVCESRPELSG--GGDSAP 1211
Query: 531 AGCSVQPWESLSSNSHTSTTSSTASSC------------DTEFTKEDEQRLKDYIQQLKN 578
+ ++P ++ + + TA S D T++ L+D +Q+L+
Sbjct: 1212 SVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEE 1271
Query: 579 DRAAVKLTMLELESIHIDPLSYDV-----KPRGDSQRLDLENAVLMQELMAMKEEMAELK 633
+LT E E + D+ + + + + + + L ELM + E MA L+
Sbjct: 1272 -----RLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
Query: 634 AQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM------RSLSSTSS 687
++L E ++ + + +A ++ +EHL++ V E + Q L + S
Sbjct: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARS 1386
Query: 688 GSKDK-----PGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKK---LKARVQE 739
K K +E A A L + + LA RE++ L+ ++QE
Sbjct: 1387 ALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE 1446
Query: 740 L-------VSALERLTKSSEIRHQQ---SAEFVNDLKRANSNLVAAYEKAKKKHQNKLKK 789
L +ALE L+ + R+Q+ E + +L++ S ++ A ++ + KL
Sbjct: 1447 LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRS-VLEHLPMAVQEREQKLTV 1505
Query: 790 LESQMMAMVERHETQVRMLKQRIALLEEEN 819
Q+ + + ETQ +L+ ++ LE+++
Sbjct: 1506 QREQIRELEKDRETQRNVLEHQLLELEKKD 1535
Score = 69.3 bits (168), Expect = 1e-11
Identities = 158/836 (18%), Positives = 313/836 (37%), Gaps = 133/836 (15%)
Query: 84 ELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPEN 143
+LH + + + D L+ + E+ ++ +E SQ E+ + R + Q+Q S E
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306
Query: 144 QSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHI-----EQLTTA 198
+ + L SEL + + ++ +++ A+ +R + E LT
Sbjct: 1307 KQ----------NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
Query: 199 SEHCDLAI---KTVEEIEGVLGRDLYP-----NLAEERSRWEKELA-GLREENESLTAML 249
EH A+ + G+L DL L E E+E A L+E+ E A
Sbjct: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
Query: 250 CSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPST 309
+ +E L T+ EE + LR +++EL+ + + +A L N+ ++
Sbjct: 1417 KALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476
Query: 310 GELSTSSSSNDI----PIAKIAERVKLSKTRSE------SSSSDRPVLGSEISSIGVSSS 359
++ + P+A KL+ R + + R VL ++ +
Sbjct: 1477 EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQ 1536
Query: 360 VAEHLAHSLQDCSNIQEIFQTLY------SHGSAISESKIREFEVETERLNSRIEHLKSQ 413
+ E +QD + L H + I+E E + E + HL
Sbjct: 1537 MIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL--- 1593
Query: 414 NDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAY------------EL 461
T+ LEE + S + ES++T L LQ +Q +++ L
Sbjct: 1594 ----TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649
Query: 462 LLALAESEQSLILGQFRAAGVGSSPGDQSG--DENITQMLKRAHDCRKTAENAAKALLMK 519
L +Q L+L + R + Q+ +E++ Q+ + + + + +
Sbjct: 1650 TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER 1709
Query: 520 LDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQ---- 575
+ G + A G SL C E E Q LKD ++Q
Sbjct: 1710 AEEGKGPSKAQRG-------SLEHMKLILRDKEKEVECQQEHIHE-LQELKDQLEQQLQG 1761
Query: 576 --LKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLEN---------AVLMQELMA 624
K ++ L+ E E + + + + +G+ + L++ A QEL A
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA 1821
Query: 625 MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSS 684
+++E + + Q E++ E + + A EQA++ ++ E+++ KEQ R
Sbjct: 1822 LQQEQQQAQGQ------EERVKEKADALQGALEQAHMT-LKERHGELQDHKEQARRLEEE 1874
Query: 685 TS------SGSKDKPGKECADAASPALSLAELRTTCSE---------------------- 716
+ ++ G A++ +L L+ C+E
Sbjct: 1875 LAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934
Query: 717 --------NELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQ---QSAEFVNDL 765
L AE ++ +E+ +AR + L AL + + + + Q + AE L
Sbjct: 1935 LKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL 1994
Query: 766 KRANSNLVAAYEKAK---KKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEE 818
+ + + L A+ + + ++ + L+ E ++ R++ V+ L+Q +A +EE
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE 2050
Score = 62.8 bits (151), Expect = 1e-09
Identities = 172/905 (19%), Positives = 326/905 (36%), Gaps = 169/905 (18%)
Query: 51 KKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKK-------IDRLQGTT 103
++L K E+S + + + + ++R+TEL +++ + K+ I L+ T
Sbjct: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
Query: 104 IREEDEYSELRSELSQSQHEVNEDSRSMDQ---DQTSVSIPENQSTMVTADMDNCSDLNS 160
E ++EL + E+ S+ Q D T V + E + + +N +L+S
Sbjct: 314 EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
Query: 161 EL---------QRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE- 210
+ + LT + +V+ R+++ L +QL E +L + +
Sbjct: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLR--------QQLAGCQEAVNLLQQQHDQ 425
Query: 211 -EIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEEL-----NRTKATMN 264
E EG R L ER + L+ E +SL SKE EL + +
Sbjct: 426 WEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL-----SKERELLQKAREELRQQLE 480
Query: 265 AIREERDRLRR-------------------------RVRE---LQTRLQSVQATGPSSPG 296
+ +E RLRR VRE LQ L ++A S
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS 540
Query: 297 RLTSTNRPI------------------------NPSTGELSTSSSSNDIPIAKI-AERVK 331
L + + S ELS+S ++ +A + A VK
Sbjct: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 332 LSKTRSESSSSDRPVLGSEI-------SSIGVSSSVAEHLAHSLQ-DCSNIQEIFQTLYS 383
LS +E+ + D+ L ++ S+ AE ++LQ D + ++ + L+
Sbjct: 601 LS-ALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
Query: 384 HGSAIS-------------ESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAER 430
+ + ++ +R+ + E E + ++ + Q + T LE+ A+R
Sbjct: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR 719
Query: 431 MSMLVGKYESNATAL---RLALQYSEQCIE-----AYELLLALAESEQSLILGQFRAAGV 482
++ + AL + AL+ Q +E E L L+ +++ L F A
Sbjct: 720 QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQ 779
Query: 483 GSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLS 542
S G + ++ ++ + + L ++LD A + +
Sbjct: 780 NSVIEVTKGQLEV--QIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837
Query: 543 SNSHTSTTSSTA------SSCDTEFTKE---DEQRLKDYIQQLKNDRAAVKLTM----LE 589
T+ A + ++ KE +Q L ++ L+ ++ +++ + E
Sbjct: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897
Query: 590 LESIHIDPLSYDVKPRGDSQRLDL----ENAVLMQELMAMKEEMAELKAQLYLLEKEKKA 645
+E+I + ++ L E L++ L+ ++E+A+ QL L ++ K
Sbjct: 898 MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957
Query: 646 LELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSG-----------SKDKPG 694
+LK Q L + E Q + +L SS +D
Sbjct: 958 QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
Query: 695 KECADAASPALSLAELRTTCSENELAAEFTNAIRREK-KLKARVQELVSALERLTKSSEI 753
+ A S L E++ E + + REK L + E L L ++ I
Sbjct: 1018 QLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSI 1077
Query: 754 RHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQM-MAMVERHETQVRMLKQRI 812
R Q+ + D++ A Q + K+L +QM + E E + L Q
Sbjct: 1078 RQQELSALRQDMQEA---------------QGEQKELSAQMELLRQEVKEKEADFLAQEA 1122
Query: 813 ALLEE 817
LLEE
Sbjct: 1123 QLLEE 1127
Score = 58.5 bits (140), Expect = 2e-08
Identities = 177/885 (20%), Positives = 323/885 (36%), Gaps = 109/885 (12%)
Query: 27 SLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELH 86
+L+G I EL K+ + + +LL L K E + E +QE R + L
Sbjct: 1439 TLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD---LQQEQIQELEKCR--SVLEHLP 1493
Query: 87 SVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQST 146
+ E +K+ +Q IRE ++ E + + + Q E M + Q + + +
Sbjct: 1494 MAVQEREQKLT-VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRG-QVQDLKKQ 1551
Query: 147 MVTADMDNCSDLNSE--------LQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA 198
+VT + C L E Q+++ LE ++ + +++ + +E+ +
Sbjct: 1552 LVTLE---CLALELEENHHKMECQQKLIKELEG-----QRETQRVALTHLTLDLEERSQE 1603
Query: 199 SEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNR 258
+ I +E VL R+L E +S+ E ++ L+ + E LT L +++EL
Sbjct: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQRE-QIEELQRQKEHLTQDLERRDQELML 1662
Query: 259 TKATMNAIREERDR---------------LRRRVRELQTRLQSVQATGPSSPGRLTSTNR 303
K + + ++R R LR R REL T+ Q +Q G +
Sbjct: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Query: 304 PINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEH 363
+ L + I E +L + +G +
Sbjct: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
Query: 364 LAHSLQDCSNIQEI-FQTLYS------HGSAISESKIREFEVETERLNSRIEHLKSQNDL 416
L LQ+ E+ Q+L S A + ++ + E ++ + E +K + D
Sbjct: 1783 LQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADA 1842
Query: 417 LTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLA-----LAESEQS 471
L LE+ + + ++ A L L + ++A E +L E E++
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKA 1902
Query: 472 LILGQFRAAGVGSSPGDQS----------------GDENITQMLKRAHDCRKTAENAAKA 515
L+ Q + A ++ D+ + + L+ + E AA+A
Sbjct: 1903 LLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQEL-EALRAESQSSRHQEEAARA 1961
Query: 516 LLMKLDGSCGGAFAV-----AGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQ--- 567
L + G A A Q S S + T+T ++ +C + +E
Sbjct: 1962 RAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021
Query: 568 ----------RLKDYIQQLKN---DRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLE 614
R ++ +QQL+ R E E + L+ V+ ++ +L
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG 2081
Query: 615 NAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQ 674
+E+ + + + EL QL L +KE++ LEL+ T++ L H H S +EEQ
Sbjct: 2082 QEREEEEIRGLHQSVREL--QLTLAQKEQEILELR-ETQQRNNLEALPH-SHKTSPMEEQ 2137
Query: 675 K------EQRM-RSLSSTSSGSKDKPGKEC---ADAASPALSLAELRTTCSENELAAEFT 724
E R+ R L + + +E A ALSLA+ + + S + A F
Sbjct: 2138 SLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFL 2197
Query: 725 NAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQ 784
A E+ + + + L R E H A +L V E + + +
Sbjct: 2198 QASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAE 2257
Query: 785 NKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 829
+E Q H L+Q +A LE + SR + L
Sbjct: 2258 PSPDGMEKQSWRQRLEH------LQQAVARLEIDRSRLQRHNVQL 2296
Score = 57.0 bits (136), Expect = 7e-08
Identities = 131/690 (18%), Positives = 255/690 (36%), Gaps = 91/690 (13%)
Query: 43 ERERDLLEKKLAKAQCEQSHL--MREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQ 100
E + +L K + +C+Q H+ ++E +D E+ ++ E ++++ ++I LQ
Sbjct: 1725 EHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784
Query: 101 GTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNS 160
++E E EL+ + QSQ ++E R++ Q + + + + +
Sbjct: 1785 -QQLQEAREQGELKEQSLQSQ--LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841
Query: 161 ELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR-- 218
LQ L + R E+ H EQ E + + V+ +E VLG
Sbjct: 1842 ALQGALEQAHMTLKERH--------GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLR 1893
Query: 219 -----------DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIR 267
L AE+ E E L++ A+L +++EL +A + R
Sbjct: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953
Query: 268 EERDRLRRRVRELQTRLQSVQATGPSSPGRL---TSTNRPINPSTGELSTSSSSNDIPIA 324
+ + R R LQ L A L +R + ST L S +
Sbjct: 1954 HQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
Query: 325 KIAERVKLSKTR--------SESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQE 376
++ E +++ + E + L + + L SL +QE
Sbjct: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL--AQRVQE 2071
Query: 377 -IFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAE------ 429
+ Q + G E +IR L ++ + + ++L + + ++N E
Sbjct: 2072 NMIQEKQNLGQEREEEEIRGLHQSVREL--QLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 430 ----------RMSMLVGKYESNATALRLALQYSE-QCIE----AYELLLALAESEQSLI- 473
++ L + + L+ AL+ +E + IE A +L L+LA+++ S+
Sbjct: 2130 KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
Query: 474 ---LGQFRAAGVGSSPGDQSGDENITQMLKRAHD--------CRKTAENAAKALLMKLDG 522
+ F A V +Q ++ ++ +RA + TAE ++ G
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG 2249
Query: 523 SCGGAFAVA---GCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKND 579
G A G Q W + + D + +L+ ++Q++ +
Sbjct: 2250 EVSGVEAEPSPDGMEKQSWRQRLEHLQQAV---ARLEIDRSRLQRHNVQLRSTLEQVERE 2306
Query: 580 RAAVK---LTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQL 636
R +K + + S+ I + + D + +A + EL ++E+ L+AQL
Sbjct: 2307 RRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAEL---QKEVVLLQAQL 2363
Query: 637 YLLEKEKKALELKLSTREAQEQAYLVHIEH 666
L K+K+ TR AQ L + H
Sbjct: 2364 TLERKQKQ----DYITRSAQTSRELAGLHH 2389
Score = 45.1 bits (105), Expect = 3e-04
Identities = 136/683 (19%), Positives = 249/683 (36%), Gaps = 124/683 (18%)
Query: 222 PNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREE-----------R 270
PNL E R E+E ++ ESL + + + A+RE+ R
Sbjct: 94 PNLDELLVRLEEE----QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR 149
Query: 271 DRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKI-AER 329
D L R+ + Q + + GRL S R + S+ D + ++ AE
Sbjct: 150 DELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEH 209
Query: 330 VKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAIS 389
V+LS + L + + V + E D ++ L
Sbjct: 210 VRLSGS-----------LLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLL-------- 250
Query: 390 ESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGK----YESNATAL 445
+K +E E E + + LKSQ DL L++ + + K YE AL
Sbjct: 251 -AKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 446 RLALQYSEQC---IEAYELLLALAESEQSLILGQF------RAAGVGSSPGDQSGDENIT 496
R ++ E + +E L+ E+ L L Q G + SG EN
Sbjct: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
Query: 497 QM----------------LKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWE- 539
++ L A + L +L G C A + WE
Sbjct: 370 ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG-CQEAVNLLQQQHDQWEE 428
Query: 540 ----------SLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLE 589
L+ T + + + ++ + L+ ++L+ +L +LE
Sbjct: 429 EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ-----QLEVLE 483
Query: 590 LESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE-KEKKALEL 648
E+ + ++ +++ +GDS + E +EL E L+ L LE K+ ++L
Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQ--QEELHLAVRERERLQEMLMGLEAKQSESLSE 541
Query: 649 KLSTREAQEQAYLVHIEHLKSEVEE------QKEQRMRSLSSTSSGSKDKPGKECADAAS 702
++ REA E ++L E L+ E E + EQ + LSS+ + K E AD +
Sbjct: 542 LITLREALESSHL-EGELLRQEQTEVTAALARAEQSIAELSSSENTLK----TEVADLRA 596
Query: 703 PALSLAEL----------------------RTTCSENELAAEFTNAIR-----REKKLKA 735
A+ L+ L ++ CS E A + NA++ EK+ +A
Sbjct: 597 AAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREA 656
Query: 736 RVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMM 795
++ +L K+ E + A+ + D++ + +++ + + +LE
Sbjct: 657 LWEKNTHLEAQLQKAEEAGAELQAD-LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
Query: 796 AMVERHETQVRMLKQRIALLEEE 818
+ E R ++++ AL+ E+
Sbjct: 716 EAKRQEEVLARAVQEKEALVREK 738
Score = 41.2 bits (95), Expect = 0.004
Identities = 53/256 (20%), Positives = 106/256 (41%), Gaps = 40/256 (15%)
Query: 24 ALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERIT 83
AL + GD+ R + E+E+ LL + A+ Q H E T ++
Sbjct: 1884 ALEEVLGDL-----RAESREQEKALLALQQQCAEQAQEH---------EVETRALQDSWL 1929
Query: 84 ELHSVIAELNKKID--RLQGTTIREEDEYSELRSELSQSQ----HEV--NEDSRSMDQDQ 135
+ +V+ E +++++ R + + R ++E + R+E Q H ++ ++Q +
Sbjct: 1930 QAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAE 1989
Query: 136 TSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQL 195
S S+ + +T+ A +D C + +L+ L E + + ++QL
Sbjct: 1990 LSRSLEASTATL-QASLDACQAHSRQLEEALRIQEGEIQDQD--------LRYQEDVQQL 2040
Query: 196 TTASEHCDLAIKTVEEIEGVLGRDLYPNLAEE---------RSRWEKELAGLREENESLT 246
A D ++ +E E +L + L + E + R E+E+ GL + L
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 247 AMLCSKEEELNRTKAT 262
L KE+E+ + T
Sbjct: 2101 LTLAQKEQEILELRET 2116
Score = 38.9 bits (89), Expect = 0.020
Identities = 126/728 (17%), Positives = 269/728 (36%), Gaps = 112/728 (15%)
Query: 12 DSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQ 71
+ S EL + S+ + L+ L + LQ+ ++E +++ + Q ++ HL ++ E
Sbjct: 1599 ERSQEL-QAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRD 1657
Query: 72 ERTTLRYEERITELHSVIAELNKKIDR-LQGTTIREEDEYSELRSELSQSQHEVNE---- 126
+ L+ +ERI L K ++ L+ + + EL ++ Q E
Sbjct: 1658 QELMLQ-KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
Query: 127 ---DSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSL 183
S++ + + E + + +L +L++ L GL RK SL
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLH-----RKVGETSL 1771
Query: 184 SVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENE 243
+++ ++ I L L E R + E + L+ + +
Sbjct: 1772 LLSQREQEIVV-------------------------LQQQLQEAREQGELKEQSLQSQLD 1806
Query: 244 SLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNR 303
L +++EL + + + +R++ + LQ L+ T G L
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKE 1866
Query: 304 PINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEH 363
EL+ + E V L R+ES ++ +L ++ +
Sbjct: 1867 QARRLEEELAVEGRR-----VQALEEV-LGDLRAESREQEKALL-----------ALQQQ 1909
Query: 364 LAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEE 423
A Q+ Q + A+ ++E + E E L + + + Q E
Sbjct: 1910 CAEQAQEHEVETRALQDSWLQAQAV----LKERDQELEALRAESQSSRHQE-------EA 1958
Query: 424 CKSNAERMSMLVGKYESNATALRLALQYSEQ-CIEAYELLLALAES----EQSLILGQFR 478
++ AE + +GK + ALQ EQ +E EL +L S + SL Q
Sbjct: 1959 ARARAEALQEALGKAHA-------ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAH 2011
Query: 479 AAGVGSSPGDQSGD---------ENITQ----MLKRAHDCRKTAEN---AAKALLMKLDG 522
+ + + Q G+ E++ Q + +R + R E K+L ++
Sbjct: 2012 SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQE 2071
Query: 523 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA 582
+ G + E + T + + E + E + ++ ++ L +
Sbjct: 2072 NMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH-- 2129
Query: 583 VKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMK---------EEMAELK 633
K + +E +S+ +D L +PR + L+ A+ E ++ +A+ K
Sbjct: 2130 -KTSPMEEQSLKLDSL----EPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK 2184
Query: 634 AQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKP 693
A + L++ L+ + R++++Q +E + +E+++ + S+ GS+ +
Sbjct: 2185 ASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ 2244
Query: 694 GKECADAA 701
G + + +
Sbjct: 2245 GVQLGEVS 2252
Score = 33.5 bits (75), Expect = 0.83
Identities = 55/262 (20%), Positives = 102/262 (38%), Gaps = 32/262 (12%)
Query: 38 RLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKID 97
+L ++E+++LE + + + L H+ T EE+ +L S+ L ++++
Sbjct: 2100 QLTLAQKEQEILELRETQQRNNLEALPHSHK------TSPMEEQSLKLDSLEPRLQRELE 2153
Query: 98 RLQGT---TIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDN 154
RLQ T E E+ E +L+ S + S+ + + Q++++ D +
Sbjct: 2154 RLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFL-----QASVLERDSEQ 2208
Query: 155 CSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEG 214
L EL+ LE R S + S AE+ EQ E V +E
Sbjct: 2209 -QRLQDELELTRRALEK---ERLHSPGATSTAELGSRGEQGVQLGE--------VSGVEA 2256
Query: 215 VLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLR 274
D E+ W + L L++ L + + ++T+ + ER +L+
Sbjct: 2257 EPSPD-----GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311
Query: 275 RR-VRELQTRLQSVQATGPSSP 295
R +R Q + SSP
Sbjct: 2312 REAMRAAQAGSLEISKATASSP 2333
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 95.1 bits (235), Expect = 2e-19
Identities = 176/895 (19%), Positives = 343/895 (38%), Gaps = 114/895 (12%)
Query: 12 DSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHL-MREHEDV 70
+ E + S L L+ + ++L +L E ERD+ KK+ + E L M + + +
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 71 QERTTLRYE----ERITEL---------HSVIAELNKKIDRLQGTTIREEDEYSELRSEL 117
E L +E R +EL H V + ++ +L+ ELR+ +
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV 483
Query: 118 SQSQHEVNEDSRSMDQDQ---TSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVV- 173
+ ++ + ++Q V I EN+ + NC +L+ +L + LE +
Sbjct: 484 DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543
Query: 174 CGRKKSSCSLSVAEVD-RHIEQLTTASEH-----CDLAIKTVEEIEGVLGRDL------- 220
R+ S + + E + H+ Q ++ + +K +E+ +L +
Sbjct: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
Query: 221 ----------------YPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMN 264
Y E E EL L +ENE +L K L T +
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE----LLQKKITNLKITCEKIE 659
Query: 265 AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIA 324
A+ +E L R R+L+ L S + L N ++ EL + S
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNL-TFQLESLEKENSQLDEENLELRRNVESLKCASM 718
Query: 325 KIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQ--DCSNIQEIFQTLY 382
K+A+ + ++ S++ L + + S E L S Q D N Q + +TL
Sbjct: 719 KMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN-QRLQKTLE 773
Query: 383 SHGSAIS--ESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSML---VGK 437
+ I ES++++ E+E + L +E LK + L +E KS + S L +
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 438 YESNATALRLALQYSEQCIEAYELLLALAESEQSLI---LGQFRAAGVGSSPGDQSGDEN 494
E LR + + +E + + E E + +G ++ + V ++ E
Sbjct: 834 LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 495 I-----------------------TQML-----KRAHDCRKTAENAAKALLMKLDGSCGG 526
+ TQ + K H+ K N K L+ + S
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN--KERLLHDEQSTDD 951
Query: 527 AFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLT 586
+ + ++ +L + A E + Q+L+ ++ +K + A+K
Sbjct: 952 RYKLLESKLE--STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Query: 587 MLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKAL 646
E + P G+ + + E+ +EL+ +K+ + E++ L+ EK+AL
Sbjct: 1010 QDEERMVQSSP-----PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1064
Query: 647 ELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALS 706
+ +L E Q I L+ + +EQ + + + +K + ++ S +L
Sbjct: 1065 KTQLKQLETQNNNLQAQILALQRQTVSLQEQ---NTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 707 LAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLK 766
+ ++ L E + I+ + LK+ L+ E+L E+ H++ A L
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL----ELLHERQASEYESLI 1177
Query: 767 RANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK--QRIALLEEEN 819
+ L +A++ + +H++ L+ +Q++ + E +MLK Q LLE +N
Sbjct: 1178 SKHGTLKSAHKNLEVEHRD-LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1231
Score = 77.8 bits (190), Expect = 4e-14
Identities = 164/864 (18%), Positives = 340/864 (39%), Gaps = 137/864 (15%)
Query: 27 SLKGDIVELNKRLQQT-ERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE- 84
+L D+++ +L++T E R+ E+++ + E HL + +++R+ + E R+ +
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
Query: 85 ------LHSVIAELNKKIDRLQ--GTTIREEDEY----SELRSELSQSQHEVNEDSRSMD 132
LH I E + K+ +++ I++E E+ E EL H + +++ +
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
Query: 133 QDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVV-----CGRKKSSCSLSVAE 187
+ T++ I + + + N +L++ L +N+ ++ S E
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 188 VDRHIEQLTTAS---EHCDLAIKTVEEIEGVL--GRDLYPNLAEERSRWEKELAGLREEN 242
+ R++E L AS L K +E + L G +L ++ R E GL EN
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 243 ESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTN 302
+ L L + +++ + ++ + + E L++ + EL+ + ++ +L N
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE--------QLEKEN 817
Query: 303 RPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAE 362
+ + T +L + ++ ++ ++ T E ++ L E + ++++
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE------NKTLSK 871
Query: 363 HLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQ---NDL--L 417
+ + C ++E+ + + + + I + T R + E LK+Q NDL L
Sbjct: 872 EIGIYKESCVRLKELEK---ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 418 TITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAES--EQSLILG 475
T LE+ N ER+ L + + Y+LL + ES ++SL +
Sbjct: 929 THELEKIGLNKERL-----------------LHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 476 QFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGS--CGGAFAVAGC 533
+ + A + + + + N Q L++ KT + +AL + D + ++G
Sbjct: 972 EEKIAALEARLEEST---NYNQQLRQE---LKTVKKNYEALKQRQDEERMVQSSPPISG- 1024
Query: 534 SVQPWESLSSNSHTSTTSSTASSCDTEFT----KEDEQRLKDYIQQLKNDRAAVKLTMLE 589
WE S + + E + ++Q LK ++QL+ ++ +L
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
Query: 590 LESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKAL--- 646
L+ + + + + +L +EN+ L + ++ + A+L Q LE E +++
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144
Query: 647 --ELK---------------LSTREAQEQAYLVHIE------HLKSEVEEQK-EQRMRSL 682
+LK L R+A E L+ H EVE + E R L
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204
Query: 683 SSTSSGSKD-------KPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKA 735
+D + K + + AE + C EN+
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND----------------- 1247
Query: 736 RVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMM 795
R+ S L + T+ + H+ +N+ K + L A + K K+++Q Q+
Sbjct: 1248 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQ--------QLD 1299
Query: 796 AMVERHETQVRMLKQRIALLEEEN 819
+ Q +L Q LEEEN
Sbjct: 1300 ITSTKLNNQCELLSQLKGNLEEEN 1323
Score = 69.7 bits (169), Expect = 1e-11
Identities = 177/917 (19%), Positives = 355/917 (38%), Gaps = 147/917 (16%)
Query: 14 SAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHE----- 68
S EL++ A + L+ ++ E ++L ++E + +E +L + Q E +L+ +
Sbjct: 250 SVELADA-KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 69 --------------DVQERTTLRYEERITEL-------------HSVIAELNKKI-DRLQ 100
D E RY+ER+ ++ + V+ E + D+L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 101 GTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS-IPENQSTMVTAD---MDNCS 156
GT R D+ EL E Q + ++++ D D+ + + E T+ A MD
Sbjct: 369 GTRARS-DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 157 DLNSELQRV--------------------LTG-------LENVVCGRKKSSCSLSVAEVD 189
L EL+++ LT +EN + +V V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 190 RHIEQLTTASEHCDLAIKTVEEIEGVLGRD---------LYPNLAEERSRWEKELAGLRE 240
+ ++ + K VE +E + ++ L +L +E+++ EK + LRE
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 241 ENESLTAMLCSKEEELNRT------------KATMNAIREERDRLRRRVRELQTRLQSVQ 288
+E +L + E LN+T +A + I +E L ++E ++L ++
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 289 ATGPSSPGRL---TSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRP 345
L EL N++ KI +K++ + E+ +
Sbjct: 608 FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT-NLKITCEKIEALEQENS 666
Query: 346 VLGSEISSIGVSSSVAEHLAHSLQ----DCSNIQEIFQTLYSHGSAI--SESKIREFEVE 399
L E + + ++L L+ + S + E L + ++ + K+ + ++E
Sbjct: 667 ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE 726
Query: 400 TERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAY 459
+ L S E LK +LL + ++ ER+ + + L+ L+ S + I+
Sbjct: 727 NKELESEKEQLKKGLELLKASFKK----TERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 460 ELLLALAESEQSLILGQFRAAGVGSSPGDQSGDEN--ITQMLKRAHDCRKTAENAAKALL 517
E L E E + + S +Q EN + Q + +K E K L
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 518 MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK 577
+ + + +++ E+ + + T S + KE RLK+ ++ K
Sbjct: 843 QQAE--------IKDTTLE--ENNVKIGNLEKENKTLSK-EIGIYKESCVRLKELEKENK 891
Query: 578 NDRAAVKLTMLELESIHIDPLSYDVKPR---GDSQRL--DLENAVLMQELMAMKEEMAEL 632
+ + L ++ D +S +K + D ++L +LE L +E + E+ +
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 633 KAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDK 692
+ +L L K + L+ L +E + A +E + +Q Q ++++ K +
Sbjct: 952 RYKL-LESKLESTLKKSLEIKEEKIAALEARLEE-STNYNQQLRQELKTVKKNYEALKQR 1009
Query: 693 PGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSE 752
+E +SP +S +N+ E R K+K R+ E +ER + +
Sbjct: 1010 QDEERMVQSSPPIS-------GEDNKWERESQETTRELLKVKDRLIE----VERNNATLQ 1058
Query: 753 IRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRI 812
Q + L+ N+NL Q ++ L+ Q +++ E++ T L+ +
Sbjct: 1059 AEKQALKTQLKQLETQNNNL-----------QAQILALQRQTVSLQEQNTT----LQTQN 1103
Query: 813 ALLEEENSRPHTNETSL 829
A L+ ENS ++ TSL
Sbjct: 1104 AKLQVENSTLNSQSTSL 1120
Score = 55.5 bits (132), Expect = 2e-07
Identities = 103/507 (20%), Positives = 204/507 (40%), Gaps = 71/507 (14%)
Query: 12 DSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQ 71
+S + E+ + L ++ +KRL+Q E+E LE++ ++ + ++ L +E++ ++
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 72 ERTTLRYEERITELHSVIAELNKKIDRLQ---GTTIREEDEYSELRSELSQSQHEVNE-D 127
++ ++ + + E N KI L+ T +E Y E L + + E E
Sbjct: 843 QQAEIK--------DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 128 SRSMDQDQTSVSIPEN--QSTMVTADMDN-CSDLNSELQRVLTG---------------- 168
R+ +T V++ E+ + T M+N L EL+++
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYK 954
Query: 169 -LENVVCGRKKSSCSL---SVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR------ 218
LE+ + K S + +A ++ +E+ T ++ +KTV++ L +
Sbjct: 955 LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1014
Query: 219 --DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEE--ELNRTKATMNAIREERDRLR 274
P ++ E ++WE RE E+ +L K+ E+ R AT+ A E+ L+
Sbjct: 1015 MVQSSPPISGEDNKWE------RESQETTRELLKVKDRLIEVERNNATLQA---EKQALK 1065
Query: 275 RRVRELQTRLQSVQA----------TGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIA 324
++++L+T+ ++QA + L + N + L++ S+S A
Sbjct: 1066 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1125
Query: 325 KIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSH 384
++ + + +ES +R L S S+ + +H L E + H
Sbjct: 1126 QLLIQQSSLENENESVIKEREDLKSLYDSL-----IKDHEKLELLHERQASEYESLISKH 1180
Query: 385 GSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATA 444
G+ S K EVE L R L Q L + K E+M + +E+ A
Sbjct: 1181 GTLKSAHK--NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAE 1238
Query: 445 LRLALQYSEQCIEAYELLLALAESEQS 471
+ +++ Y LL E Q+
Sbjct: 1239 YKKLCGENDRLNHTYSQLLKETEVLQT 1265
Score = 32.7 bits (73), Expect = 1.4
Identities = 36/134 (26%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 293 SSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSES-SSSDRPVLGSEI 351
SS G +RP + +G STS+S+N+ + ++ +++R +S SS + +L
Sbjct: 1573 SSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHE 1632
Query: 352 SSIGVSSSVAEHLAHSLQDCSNIQ-EIFQTLYSH------GSAISE-SKIREFEVETERL 403
+ SS ++L + +Q +I +TL S GS SE +++F E+ +L
Sbjct: 1633 AWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKL 1692
Query: 404 NSRIEHLKSQNDLL 417
S SQ +LL
Sbjct: 1693 TSVQIKSSSQENLL 1706
Score = 30.8 bits (68), Expect = 5.4
Identities = 53/293 (18%), Positives = 116/293 (39%), Gaps = 31/293 (10%)
Query: 550 TSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQ 609
+SS S C + K E R + +L + +A ++ ELE + + + + +
Sbjct: 228 SSSAQSPCGSPGMKRTESR-QHLSVELADAKAKIRRLRQELE----EKTEQLLDCKQELE 282
Query: 610 RLDLENAVLMQELMAMKEEMAELKAQLYLLE----KEKKALELKLSTREAQEQAYLVHIE 665
++++E L QE M + + A++Y E +EK KL + ++ + L IE
Sbjct: 283 QMEIELKRLQQENMNLLSDARS--ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIE 340
Query: 666 HLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTN 725
K+ VEE KE L + + G L L+ +++ E
Sbjct: 341 FYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM 400
Query: 726 AIRREKKLKARVQELVSA--------------LERLTKSSEIRHQQSAEFVNDLKRANSN 771
++ ++L L A LE+++++SE+ +++ S+
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 772 LVAAYEKAKKKHQNKLKKLESQM------MAMVERHETQVRMLKQRIALLEEE 818
+ E + +++L + + + + + E + + L +++ +LE E
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE 513
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 93.6 bits (231), Expect = 7e-19
Identities = 175/895 (19%), Positives = 342/895 (38%), Gaps = 113/895 (12%)
Query: 12 DSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHL-MREHEDV 70
+ E + S L L+ + ++L +L E ERD+ KK+ + E L M + + +
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 71 QERTTLRYE----ERITEL---------HSVIAELNKKIDRLQGTTIREEDEYSELRSEL 117
E L +E R +EL H V + ++ +L+ ELR+ +
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV 483
Query: 118 SQSQHEVNEDSRSMDQDQT---SVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVV- 173
+ ++ + ++Q V I EN+ + NC +L+ +L + LE +
Sbjct: 484 DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543
Query: 174 CGRKKSSCSLSVAEVDR-HIEQLTTASEH-----CDLAIKTVEEIEGVLGRDL------- 220
R+ S + + E + H+ Q ++ + +K +E+ +L +
Sbjct: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
Query: 221 ----------------YPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMN 264
Y E E EL L +ENE +L K L T +
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE----LLQKKITNLKITCEKIE 659
Query: 265 AIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIA 324
A+ +E L R R+L+ L S + L N ++ EL + S
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLES-LEKENSQLDEENLELRRNVESLKCASM 718
Query: 325 KIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQ--DCSNIQEIFQTLY 382
K+A+ + ++ S++ L + + S E L S Q D N Q + +TL
Sbjct: 719 KMAQL----QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN-QRLQKTLE 773
Query: 383 SHGSAIS--ESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVG---K 437
+ I ES++++ E+E + L +E LK + L +E KS + S L +
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 438 YESNATALRLALQYSEQCIEAYELLLALAESEQSLI---LGQFRAAGVGSSPGDQSGDEN 494
E LR + + +E + + E E + +G ++ + V ++ E
Sbjct: 834 LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 495 I-----------------------TQML-----KRAHDCRKTAENAAKALLMKLDGSCGG 526
+ TQ + K H+ K N + LL +
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER-LLHDEQSTDDS 952
Query: 527 AFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLT 586
+ + ++ +L + A E + Q+L+ ++ +K + A+K
Sbjct: 953 RYKLLESKLE--STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1010
Query: 587 MLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKAL 646
E + P G+ + + E+ +EL+ +K+ + E++ L+ EK+AL
Sbjct: 1011 QDEERMVQSSP-----PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1065
Query: 647 ELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALS 706
+ +L E Q I L+ + +EQ + + + +K + ++ S +L
Sbjct: 1066 KTQLKQLETQNNNLQAQILALQRQTVSLQEQ---NTTLQTQNAKLQVENSTLNSQSTSLM 1122
Query: 707 LAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLK 766
+ ++ L E + I+ + LK+ L+ E+L E+ H++ A L
Sbjct: 1123 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL----ELLHERQASEYESLI 1178
Query: 767 RANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK--QRIALLEEEN 819
+ L +A++ + +H++ L+ +Q++ + E +MLK Q LLE +N
Sbjct: 1179 SKHGTLKSAHKNLEVEHRD-LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1232
Score = 76.6 bits (187), Expect = 9e-14
Identities = 166/866 (19%), Positives = 341/866 (39%), Gaps = 140/866 (16%)
Query: 27 SLKGDIVELNKRLQQT-ERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE- 84
+L D+++ +L++T E R+ E+++ + E HL + +++R+ + E R+ +
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
Query: 85 ------LHSVIAELNKKIDRLQ--GTTIREEDEY----SELRSELSQSQHEVNEDSRSMD 132
LH I E + K+ +++ I++E E+ E EL H + +++ +
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
Query: 133 QDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVV-----CGRKKSSCSLSVAE 187
+ T++ I + + + N +L++ L +N+ ++ S E
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 188 VDRHIEQLTTAS---EHCDLAIKTVEEIEGVL--GRDLYPNLAEERSRWEKELAGLREEN 242
+ R++E L AS L K +E + L G +L ++ R E GL EN
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 243 ESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTN 302
+ L L + +++ + ++ + + E L++ + EL+ + ++ +L N
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE--------QLEKEN 817
Query: 303 RPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAE 362
+ + T +L + ++ ++ ++ T E ++ L E + ++++
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE------NKTLSK 871
Query: 363 HLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQ---NDL--L 417
+ + C ++E+ + + + + I + T R + E LK+Q NDL L
Sbjct: 872 EIGIYKESCVRLKELEK---ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 418 TITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIE--AYELLLALAES--EQSLI 473
T LE+ N ER L + EQ + Y+LL + ES ++SL
Sbjct: 929 THELEKIGLNKER------------------LLHDEQSTDDSRYKLLESKLESTLKKSLE 970
Query: 474 LGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGS--CGGAFAVA 531
+ + + A + + + + N Q L++ KT + +AL + D + ++
Sbjct: 971 IKEEKIAALEARLEEST---NYNQQLRQE---LKTVKKNYEALKQRQDEERMVQSSPPIS 1024
Query: 532 GCSVQPWESLSSNSHTSTTSSTASSCDTEFT----KEDEQRLKDYIQQLKNDRAAVKLTM 587
G WE S + + E + ++Q LK ++QL+ ++ +
Sbjct: 1025 G-EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Query: 588 LELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKAL- 646
L L+ + + + + +L +EN+ L + ++ + A+L Q LE E +++
Sbjct: 1084 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1143
Query: 647 ----ELK---------------LSTREAQEQAYLVHIE------HLKSEVEEQK-EQRMR 680
+LK L R+A E L+ H EVE + E R
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 681 SLSSTSSGSKD-------KPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKL 733
L +D + K + + AE + C EN+
Sbjct: 1204 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--------------- 1248
Query: 734 KARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQ 793
R+ S L + T+ + H+ +N+ K + L A + K K+++Q Q
Sbjct: 1249 --RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQ--------Q 1298
Query: 794 MMAMVERHETQVRMLKQRIALLEEEN 819
+ + Q +L Q LEEEN
Sbjct: 1299 LDITSTKLNNQCELLSQLKGNLEEEN 1324
Score = 55.5 bits (132), Expect = 2e-07
Identities = 101/508 (19%), Positives = 203/508 (39%), Gaps = 72/508 (14%)
Query: 12 DSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQ 71
+S + E+ + L ++ +KRL+Q E+E LE++ ++ + ++ L +E++ ++
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 72 ERTTLRYEERITELHSVIAELNKKIDRLQ---GTTIREEDEYSELRSELSQSQHEVNE-D 127
++ ++ + + E N KI L+ T +E Y E L + + E E
Sbjct: 843 QQAEIK--------DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 128 SRSMDQDQTSVSIPEN--QSTMVTADMDN-CSDLNSELQRVLTGLENVVCGRKKSSCSL- 183
R+ +T V++ E+ + T M+N L EL+++ E ++ + + S
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRY 954
Query: 184 --------------------SVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR----- 218
+A ++ +E+ T ++ +KTV++ L +
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1014
Query: 219 ---DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEE--ELNRTKATMNAIREERDRL 273
P ++ E ++WE RE E+ +L K+ E+ R AT+ A E+ L
Sbjct: 1015 RMVQSSPPISGEDNKWE------RESQETTRELLKVKDRLIEVERNNATLQA---EKQAL 1065
Query: 274 RRRVRELQTRLQSVQA----------TGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPI 323
+ ++++L+T+ ++QA + L + N + L++ S+S
Sbjct: 1066 KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQN 1125
Query: 324 AKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYS 383
A++ + + +ES +R L S S+ + +H L E +
Sbjct: 1126 AQLLIQQSSLENENESVIKEREDLKSLYDSL-----IKDHEKLELLHERQASEYESLISK 1180
Query: 384 HGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNAT 443
HG+ S K EVE L R L Q L + K E+M + +E+ A
Sbjct: 1181 HGTLKSAHK--NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238
Query: 444 ALRLALQYSEQCIEAYELLLALAESEQS 471
+ +++ Y LL E Q+
Sbjct: 1239 EYKKLCGENDRLNHTYSQLLKETEVLQT 1266
Score = 38.9 bits (89), Expect = 0.020
Identities = 56/256 (21%), Positives = 109/256 (42%), Gaps = 18/256 (7%)
Query: 582 AVKLTMLELESIHIDPLSYDVK-PRGDSQRLDLENAVLMQELMAMKEEMAELKAQ---LY 637
AV++ LE E +D++ + + L +N VL++ +++++ +A+ L+
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 638 LLEKEKKALELKLSTREAQEQAYLVHIEHLKSE----VEEQKEQRMRSLSSTSSGSKDKP 693
LEKE L+ KL E + IE L E QK+ SL +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 438
Query: 694 GKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERL--TKSS 751
E ++A +L E+ S L E N + L V+EL + ++ + S
Sbjct: 439 TSELSEAPQKSLG-HEVNELTSSRLLKLEMEN-----QSLTKTVEELRTTVDSVEGNASK 492
Query: 752 EIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 811
++ ++ + ++ N + +++ + QN K L + + + ET +++
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 812 IALLEEENSRPHTNET 827
I +LE+EN H N+T
Sbjct: 553 IKILEQENE--HLNQT 566
Score = 33.5 bits (75), Expect = 0.83
Identities = 91/433 (21%), Positives = 167/433 (38%), Gaps = 55/433 (12%)
Query: 11 NDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDV 70
N+S E + L A + LK +L+ + + +LL + + E HL+ + + +
Sbjct: 1276 NNSKLEQTRLE-AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 1334
Query: 71 --QERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDS 128
Q RT L +L V E + ID+L +ELR + + + ++ +
Sbjct: 1335 MLQNRTLLEQNMESKDLFHV--EQRQYIDKL-----------NELRRQKEKLEEKIMDQY 1381
Query: 129 RSMDQDQTSVSIPENQSTMVTADMDNC----SDLNSELQRVLTGLENVVCGRKKSSCSLS 184
+ D S P + +T M D+N E Q+ LT +S S
Sbjct: 1382 KFYDP-----SPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPT------RSDSSEG 1430
Query: 185 VAEVDRHIEQLTTASEHCDLAI-KTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENE 243
++ Q +++ L +T+ + DL ++ +W L ++
Sbjct: 1431 FLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLA-GQWTGSTENLEVPDD 1489
Query: 244 SLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQ-------TRLQSVQATG---PS 293
T + +EL + AI R Q T + + G S
Sbjct: 1490 ISTG---KRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDS 1546
Query: 294 SPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSES-SSSDRPVLGSEIS 352
S G +RP + +G STS+S+N+ + ++ +++R +S SS + +L +
Sbjct: 1547 STGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEA 1606
Query: 353 SIGVSSSVAEHLAHSLQDCSNIQ-EIFQTLYSH------GSAISE-SKIREFEVETERLN 404
SS ++L + +Q +I +TL S GS SE +++F E+ +L
Sbjct: 1607 WSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLT 1666
Query: 405 SRIEHLKSQNDLL 417
S SQ +LL
Sbjct: 1667 SVQIKSSSQENLL 1679
Score = 30.8 bits (68), Expect = 5.4
Identities = 53/293 (18%), Positives = 116/293 (39%), Gaps = 31/293 (10%)
Query: 550 TSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQ 609
+SS S C + K E R + +L + +A ++ ELE + + + + +
Sbjct: 228 SSSAQSPCGSPGMKRTESR-QHLSVELADAKAKIRRLRQELE----EKTEQLLDCKQELE 282
Query: 610 RLDLENAVLMQELMAMKEEMAELKAQLYLLE----KEKKALELKLSTREAQEQAYLVHIE 665
++++E L QE M + + A++Y E +EK KL + ++ + L IE
Sbjct: 283 QMEIELKRLQQENMNLLSDARS--ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIE 340
Query: 666 HLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTN 725
K+ VEE KE L + + G L L+ +++ E
Sbjct: 341 FYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM 400
Query: 726 AIRREKKLKARVQELVSA--------------LERLTKSSEIRHQQSAEFVNDLKRANSN 771
++ ++L L A LE+++++SE+ +++ S+
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 772 LVAAYEKAKKKHQNKLKKLESQM------MAMVERHETQVRMLKQRIALLEEE 818
+ E + +++L + + + + + E + + L +++ +LE E
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE 513
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 89.7 bits (221), Expect = 1e-17
Identities = 163/867 (18%), Positives = 341/867 (39%), Gaps = 107/867 (12%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+AS+K + L + L+++E R LE+K+ E++ L + + Q+ EER +
Sbjct: 849 MASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA-DAEERCDQ 907
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
L +L K+ + EE+ +EL ++ + + E +E R +D + +++ E +
Sbjct: 908 LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKE 967
Query: 145 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDL 204
+ N L + GL+ ++ K +L A + ++ L + +
Sbjct: 968 KHATENKVKN-------LTEEMAGLDEIIAKLTKEKKALQEAH-QQALDDLQAEEDKVNT 1019
Query: 205 AIKT-------VEEIEGVLGRDLYPNLAEERSRWEKE---------LAGLREENESLTAM 248
K V+++EG L ++ + ER++ + E + L + + L
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Query: 249 LCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV------QATGPSSPGRLTS-T 301
L K+ ELN A + + +L+++++ELQ R++ + + T + +L S
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 1139
Query: 302 NRPINPSTGELSTSSSSNDIPIAKIAER-VKLSKTRSESSSSDRPVLGSEISSIGVSSSV 360
+R + + L + + + I +R + K R + + L E ++ +
Sbjct: 1140 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD---LEEATLQHEATAAALRKKH 1196
Query: 361 AEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL---KSQNDLL 417
A+ +A + N+Q + Q L E + EF++E + + S +E + K+ + +
Sbjct: 1197 ADSVAELGEQIDNLQRVKQKL--------EKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Query: 418 TITLE----ECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLI 473
TLE E +S AE V S L+ + ++ E L++ +
Sbjct: 1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY 1308
Query: 474 LGQFRAAGVGSSPGDQSGDENITQMLKRAHDC-----RKTAENAAKALLMKLDGSCGGAF 528
Q ++ + + HDC + E AKA L ++
Sbjct: 1309 TQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV-------L 1361
Query: 529 AVAGCSVQPW-------------------ESLSSNSHTSTTSSTASSCDTEFTKEDEQRL 569
+ A V W + L+ + + A + ++ + RL
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421
Query: 570 KDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENA-----VLMQEL 622
++ I+ L D R+ L+ + + D + + K + + + +LE++ L EL
Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Query: 623 MAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVH-IEHLKSEVEEQKEQRM 679
+K E L ++E K L+ ++S T + +H +E ++ ++E +K +
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ 1541
Query: 680 RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE 739
+L + + + GK AE+ +E + E A R ++ V
Sbjct: 1542 SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD--EEMEQAKRNHLRV---VDS 1596
Query: 740 LVSALERLTKSSEIRHQQSAEFVNDLKRAN------SNLVAAYEKAKKKHQNKLKKLESQ 793
L ++L+ T+S + + DL + + A +K K Q+ LK + Q
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1656
Query: 794 MMAMVERHETQVRMLKQRIALLEEENS 820
+ V ++ LK+ IA++E N+
Sbjct: 1657 LDDAVRANDD----LKENIAIVERRNN 1679
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/686 (18%), Positives = 272/686 (39%), Gaps = 96/686 (13%)
Query: 11 NDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDV 70
++ A +S+L L + + +L ++L++ + ++ L L A+ L+RE +
Sbjct: 1292 DEKEALISQLTRGKLTYTQ-QLEDLKRQLEEEVKAKNALAHALQSAR-HDCDLLREQYEE 1349
Query: 71 QERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRS 130
+ + +++ +S +A+ K + I+ +E E + +L+Q E E
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYET---DAIQRTEELEEAKKKLAQRLQEAEE---- 1402
Query: 131 MDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEV-D 189
V A CS L R+ +E+++ ++S+ + + +
Sbjct: 1403 ----------------AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446
Query: 190 RHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGL---REENESLT 246
R+ +++ + ++ E R L L + ++ +E+ L L + EN++L
Sbjct: 1447 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1506
Query: 247 AMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPIN 306
+ E+L + T++ + + R +L ELQ+ L+ +A+ G++ N
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 307 PSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD------RPVLGSEISSIGVSSSV 360
E+ + D + + A+R L S +S D L + G + +
Sbjct: 1567 QIKAEIERKLAEKDEEMEQ-AKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM 1625
Query: 361 AEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEV--ETERLNSRIEHLKSQNDLLT 418
L+H+ + + Q+ ++L S + +++I+ + + L I ++ +N+LL
Sbjct: 1626 EIQLSHANRMAAEAQKQVKSLQ---SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ 1682
Query: 419 ITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFR 478
LEE ++ E+ + +LA ++ IE E + L SLI + +
Sbjct: 1683 AELEELRAVVEQ----------TERSRKLA---EQELIETSERVQLLHSQNTSLINQKKK 1729
Query: 479 AAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPW 538
D + T++ + +CR E A KA+ A +A
Sbjct: 1730 M--------DADLSQLQTEVEEAVQECRNAEEKAKKAIT--------DAAMMA------- 1766
Query: 539 ESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQL-KNDRAAVKLTMLELESIHIDP 597
E L TS K EQ +KD +L + ++ A+K +L+ +
Sbjct: 1767 EELKKEQDTSAHLE-------RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL---- 1815
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQE 657
+ + R L+ E + + M++ +K Y E+++K L L+L +
Sbjct: 1816 ---EARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNL-LRLQDLVDKL 1871
Query: 658 QAYLVHIEHLKSEVEEQKEQRMRSLS 683
Q + ++ K + EE +EQ +LS
Sbjct: 1872 Q---LKVKAYKRQAEEAEEQANTNLS 1894
Score = 42.4 bits (98), Expect = 0.002
Identities = 53/231 (22%), Positives = 108/231 (46%), Gaps = 29/231 (12%)
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEM-------AELKAQLYLLEKEKKALELKL 650
L + +KP S + E A + +E +KE + EL+ ++ L +EK L+L++
Sbjct: 832 LYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQV 891
Query: 651 STR-----EAQEQA--YLVHIEHLKSEVEEQKE--QRMRSLSSTSSGSKDKPGKECADAA 701
+A+E+ + + L+++V+E E + +++ + K K EC++
Sbjct: 892 QAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 951
Query: 702 SPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSAE 760
+ +L T ++ E T N ++ + A + E+++ L + K+ + HQQ+
Sbjct: 952 R---DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA-- 1006
Query: 761 FVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 811
++DL +A + V KAK K + ++ LE + E +VRM +R
Sbjct: 1007 -LDDL-QAEEDKVNTLTKAKVKLEQQVDDLEGSL-----EQEKKVRMDLER 1050
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 86.7 bits (213), Expect = 8e-17
Identities = 166/905 (18%), Positives = 353/905 (39%), Gaps = 130/905 (14%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLR------Y 78
+A++K + + + L +TE +R LE+K+ LM+E D+Q +
Sbjct: 853 MANMKEEFEKTKEELAKTEAKRKELEEKMVT-------LMQEKNDLQLQVQAEADSLADA 905
Query: 79 EERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSV 138
EER +L +L KI + T R EDE E+ +EL+ + ++ ++ + +D
Sbjct: 906 EERCDQLIKTKIQLEAKIKEV---TERAEDE-EEINAELTAKKRKLEDECSELKKD---- 957
Query: 139 SIPENQSTMVTADMDNCSDLN--SELQRVLTGLENVVCGRKKSSCSLSVA------EVDR 190
I + + T+ + + + N L + GL+ + K +L A ++
Sbjct: 958 -IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1016
Query: 191 HIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKE---------LAGLREE 241
+++ T ++ + V+++EG L ++ + ER++ + E + +
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEND 1076
Query: 242 NESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTST 301
+ L L KE E++ ++ + + +L+++++ELQ R++ ++ +
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 302 NRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS-----DRPVLGSEISSIGV 356
+ + + EL S + + +++++K R + L E ++ +
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196
Query: 357 SSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDL 416
A+ +A + N+Q + Q L S + + +I + E ++ +L+
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEM-KMEIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 417 LTITLEECKSNAERMSMLVGKYESNATALRLALQ-----YSEQCIEAYELLLALAESEQS 471
L L E K+ E L+ ++ TA R LQ YS Q E L+ L+ +Q+
Sbjct: 1256 LEDQLSEIKTKEEEQQRLI----NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA 1311
Query: 472 LILGQFRAAGVGSSPGDQSGDENITQMLKRAHDC-----RKTAENAAKALLMKLDGSCGG 526
Q ++ + HDC + E AKA L +
Sbjct: 1312 -FTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQR------- 1363
Query: 527 AFAVAGCSVQPW-------------------ESLSSNSHTSTTSSTASSCDTEFTKEDEQ 567
A + A V W + L+ + A + ++ +Q
Sbjct: 1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 568 RLKDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDL-----ENAVLMQ 620
RL++ ++ L D R L+ + + D + + K + + +L E+ L
Sbjct: 1424 RLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLST 1483
Query: 621 ELMAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVH-IEHLKSEVEEQKEQ 677
EL +K E QL L++E K L+ ++S T + E +H +E +K +VE++K +
Sbjct: 1484 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 678 RMRSLSSTSSGSKDKPGK------------------------ECADAASPALSLAELRTT 713
+L + + + GK E + + E +
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603
Query: 714 CSENELAAEFTNAIRREKKLKARVQEL---VSALERLTKSSEIRHQQSAEFVNDLKRANS 770
+ E+ + +AIR +KK++ + E+ ++ R+ + ++ + + D +
Sbjct: 1604 TLDAEIRSR-NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLD 1662
Query: 771 NLVAAYEKAK------KKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHT 824
+ + + E K ++ N L+ ++ A +E+ E ++ +Q + E HT
Sbjct: 1663 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1722
Query: 825 NETSL 829
TSL
Sbjct: 1723 QNTSL 1727
Score = 59.3 bits (142), Expect = 1e-08
Identities = 121/615 (19%), Positives = 233/615 (37%), Gaps = 65/615 (10%)
Query: 232 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQ--- 288
EKE+A ++EE E +EEL +T+A + E+ L + +LQ ++Q+
Sbjct: 850 EKEMANMKEEFE-------KTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902
Query: 289 ATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLG 348
A +L T + E++ + + A++ + + + D L
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 349 SEISSIGVSSSVAEHLAHSL-QDCSNIQEIFQTLYSHGSAISES---KIREFEVETERLN 404
++ + E+ +L ++ + + E L A+ E+ + + + E +++N
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1022
Query: 405 SRIE---HLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYEL 461
+ + L+ Q D L +LE+ K + K E + L+LA Q S IE +
Sbjct: 1023 TLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD---LKLA-QESTMDIENDKQ 1078
Query: 462 LLALAESEQSLILGQFRAAGVGSSPGDQSG-----DENITQMLKRAHDCRK--TAENAAK 514
L ++ L +F +G+ S D+ + I ++ R + + AE A++
Sbjct: 1079 QL-----DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASR 1133
Query: 515 ALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQ 574
A K L S + A+S E K+ E + +
Sbjct: 1134 AKAEKQRSDLS-------------RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 575 QLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKA 634
L+ + T L H D ++ + + QR+ + L +E MK E+ +L +
Sbjct: 1181 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK---LEKEKSEMKMEIDDLAS 1237
Query: 635 QLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-----QRMRSLSSTSSGS 689
+ + K K LE E Q + +K++ EEQ+ R+ T SG
Sbjct: 1238 NMETVSKAKGNLEKMCRALEDQ-------LSEIKTKEEEQQRLINDLTAQRARLQTESGE 1290
Query: 690 KDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTK 749
+ E D LS + T EL + I+ + L +Q + L +
Sbjct: 1291 YSRQLDE-KDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLRE 1349
Query: 750 SSEIRHQQSAEFVNDLKRANSNLV---AAYEKAKKKHQNKLKKLESQMMAMVERHETQVR 806
E + AE + +ANS + YE + +L++ + ++ ++ E V
Sbjct: 1350 QYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 807 MLKQRIALLEEENSR 821
+ + A LE+ R
Sbjct: 1410 AVNAKCASLEKTKQR 1424
Score = 48.5 bits (114), Expect = 2e-05
Identities = 83/430 (19%), Positives = 177/430 (41%), Gaps = 51/430 (11%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQC--EQSHLMREHEDVQE-RTTLRYEER 81
++ L I E KR+ + E+ + +E++ ++ Q E++ EHE+ + R L +
Sbjct: 1513 ISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQV 1572
Query: 82 ITELHSVIAELNKKIDRLQGTTIR-EEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSI 140
+E+ IAE +++ID+++ IR E S L +E+ +S+++ + M+ D + I
Sbjct: 1573 KSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEI-RSRNDAIRLKKKMEGDLNEMEI 1631
Query: 141 PENQSTMVTAD-MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS 199
N + + A+ + N + + L+ L++ + R + +A V+R L
Sbjct: 1632 QLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL--RSQEDLKEQLAMVERRANLLQAEI 1689
Query: 200 EHCDLAIKTVEEIEGVLGRDLYP-------------NLAEERSRWEKELAGLREENESLT 246
E ++ E + ++L +L + + E +++ ++ E E +
Sbjct: 1690 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDII 1749
Query: 247 AMLCSKEEELNR--TKATMNA--IREERD----------RLRRRVRELQTRL-QSVQATG 291
+ EE+ + T A M A +++E+D L + V++LQ RL ++ Q
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1809
Query: 292 PSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDR------- 344
++ + GE+ + N + + + + K + + DR
Sbjct: 1810 KGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQ 1869
Query: 345 ---PVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETE 401
L +++ S + AE Q N+ + + + A + I E +V
Sbjct: 1870 DLVDKLQAKVKSYKRQAEEAEE-----QSNVNLSKFRRIQHELEEAEERADIAESQVNKL 1924
Query: 402 RLNSRIEHLK 411
R+ SR H K
Sbjct: 1925 RVKSREVHTK 1934
Score = 45.4 bits (106), Expect = 2e-04
Identities = 56/232 (24%), Positives = 106/232 (45%), Gaps = 31/232 (13%)
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 650
L + +KP S + E A + +E KEE+A EL+ ++ L +EK L+L++
Sbjct: 836 LYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895
Query: 651 -----STREAQEQA-----YLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADA 700
S +A+E+ + +E EV E+ E +++ + K K EC++
Sbjct: 896 QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSEL 954
Query: 701 ASPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSA 759
+ +L T ++ E T N ++ + A + E ++ L + K+ + HQQ+
Sbjct: 955 KK---DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT- 1010
Query: 760 EFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 811
++DL +A + V KAK K + ++ LE + E ++RM +R
Sbjct: 1011 --LDDL-QAEEDKVNTLTKAKIKLEQQVDDLEGSL-----EQEKKIRMDLER 1054
Score = 40.4 bits (93), Expect = 0.007
Identities = 56/275 (20%), Positives = 112/275 (40%), Gaps = 38/275 (13%)
Query: 28 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 87
L+ +I EL L+QTER R + E++L D ER L + + T L +
Sbjct: 1685 LQAEIEELRATLEQTERSRKIAEQELL--------------DASERVQLLHTQN-TSLIN 1729
Query: 88 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTM 147
+L I ++QG ED E R+ +++ + + + ++ + ++ S
Sbjct: 1730 TKKKLETDISQIQGEM---EDIIQEARNAEEKAKKAITDAAMMAEE----LKKEQDTSAH 1782
Query: 148 VTADMDNCSDLNSELQRVLTGLENVVC-GRKKSSCSLSV----------AEVDRHIEQLT 196
+ N +LQ L E + G KK L +E R++E +
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842
Query: 197 TASEH----CDLAIKTVEEIEGVLG-RDLYPNLAEERSRWEKELAGLREENESLTAMLCS 251
+H +L +T E+ + +L +DL L + ++++ E++ +
Sbjct: 1843 GLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRR 1902
Query: 252 KEEELNRTKATMNAIREERDRLRRRVRELQTRLQS 286
+ EL + + + ++LR + RE+ T++ S
Sbjct: 1903 IQHELEEAEERADIAESQVNKLRVKSREVHTKIIS 1937
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 84.7 bits (208), Expect = 3e-16
Identities = 170/903 (18%), Positives = 350/903 (38%), Gaps = 143/903 (15%)
Query: 29 KGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSV 88
+ ++ EL ++ Q E++LL+++L ++ L E E+++ R + +E LH +
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQA----ETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 89 IAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMV 148
A L ++ DR Q + + E ++ ++ + ++ E+ + + Q E + +
Sbjct: 928 EARLEEEEDRGQ----QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983
Query: 149 TADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASE-------H 201
++ D N++L + LE + S + ++AE + + LT
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERI-----SDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 202 CDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 261
++ +K E+ L + L L + S + +++A L+ + L L KEEEL A
Sbjct: 1039 LEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 262 TMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDI 321
++ +++ +++REL+ + +Q S + EL + +
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 322 PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVS--------SSVAEHLAHSLQDC-- 371
+ A + +L R + + + L E S + E L L+
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 372 --SNIQEIFQTLYSHGSAIS---------------------------ESKIREFEVETER 402
+N+ + QTL + ++ +SK + E
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 403 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 462
LN ++ L+++ + +T L E + A +++ V S + LQ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 463 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 522
L E E++ + Q Q+ + +I+ + + D +K ++ A + +G
Sbjct: 1338 LRQLEEERNSLQDQLDE----EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 523 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA 582
+ + Q E ++ T + +Q L D + L N R
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL-----------QQELDDLVVDLDNQRQL 1442
Query: 583 V--------KLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVL-----MQELMAMKEEM 629
V K L E +I D + R +++ + E L ++E + KEE+
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 630 AE----LKAQL--------------YLLEKEKKALELKLSTREAQ-----------EQAY 660
LKA++ + LEK K+ALE ++ + Q E A
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 661 L---VHIEHLKSEVE-------EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL 710
L V+++ LK + E EQ E++ R L + + E A A + +L
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 711 RTTCSENELAAEFT-----NAIRREKKLKARVQELVSALE-------RLTKSSEIRHQQS 758
+ EL A+ AI++ +KL+A++++ LE + +++ +++
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 759 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH---ETQVRMLKQRIALL 815
DL + +L AA E+A+K+ + ++L ++ + + + + R L+ RIA L
Sbjct: 1683 KSLEADLMQLQEDLAAA-ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 816 EEE 818
EEE
Sbjct: 1742 EEE 1744
Score = 83.6 bits (205), Expect = 7e-16
Identities = 156/874 (17%), Positives = 340/874 (38%), Gaps = 100/874 (11%)
Query: 23 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEE 80
A + L+ +I+ ++ + + +ER LLE++++ ++L E E + T L ++E
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDL---TTNLAEEEEKAKNLTKLKNKHES 1034
Query: 81 RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSI 140
I+EL + + K L+ + E + S+ +++ Q ++ E + + + +
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1094
Query: 141 PENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK--KSSCSLSVAEVDRHIEQLTTA 198
+ A +N EL+ ++ L+ + + ++ ++ +E L T
Sbjct: 1095 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Query: 199 SEHCDLAIKTVEEIEGVLGRD---LYPNLAEERSRWEKELAGLREENESLTAMLCSKEEE 255
E + T +E+ ++ L L EE E ++ +R+++ L + E+
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 256 LNRTKATMN------------------AIREERDRLRRRVRELQTRLQSVQATGPSSPGR 297
R KA ++ + + + + + ++L+ ++Q +Q+
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 298 LTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI-SSIGV 356
N ++ E+ + + + K + K + S + +L E + V
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 357 SSSV--AEHLAHSLQD-CSNIQEIFQTLYSHGSAI------SESKIREFEVETERLNSRI 407
S+ + E +SLQD E Q L H S + S+ K+++F E L
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 408 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCI-------EAYE 460
+ + + + LT EE + +++ + + L + L Q + ++
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 461 LLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKL 520
LLA E S R + ++ ++ + L+ A + ++ E K L ++
Sbjct: 1455 QLLA-EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 521 DGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDR 580
+ V + + N H S A E K + L+D +Q ++ +
Sbjct: 1514 ED-----------LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 581 AAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE 640
+++ M L+ D++ R + + + L ++L + E+ + + Q L
Sbjct: 1563 LRLEVNMQALKG----QFERDLQARDEQN--EEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 641 KEKKALELKLSTREAQEQAYL--------------VHIEHLKSEVEEQKEQRMRSLSSTS 686
KK LE L E Q + + ++ + E+E+ + R ++
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 687 SGSKDKPG--------KECADAASPALSLAELRTTCSENELAAEFT--NAIRREK-KLKA 735
K +E AA A A+L ELA+ + NA++ EK +L+A
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 736 RVQELVSALE-----------RLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQ 784
R+ +L LE R+ K+++ Q S E + A N +A ++ +++++
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN-ESARQQLERQNK 1795
Query: 785 NKLKKLESQMMAMVERHETQVRMLKQRIALLEEE 818
KL A+ + ++ + L+ +IA LEE+
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Score = 82.4 bits (202), Expect = 2e-15
Identities = 177/855 (20%), Positives = 332/855 (38%), Gaps = 114/855 (13%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+ L+G I +L + L R+ EK+ E L E ED + T + E R +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR-AK 1171
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
+ L K +D T E + E+R + +Q+ E+ E + ++ +N+
Sbjct: 1172 REQEVTVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKANLDKNK 1226
Query: 145 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA-SEHCD 203
T+ + D +L RVL G KK V E+ A +E D
Sbjct: 1227 QTLEKENADLAGEL-----RVL-GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 204 LAIKTVEEIEGVLGRDLYPNLAEERS-RWEKELAGLREENESLTAMLCSKEEELNRTKAT 262
K E+E V G N AE ++ + K++A L + + +L + +
Sbjct: 1281 KVHKLQNEVESVTG---MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 263 MNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPIN--PSTGE-LSTSSSSN 319
+ + EER+ L+ ++ E Q+++ + +L+ + + + ST E L
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 320 DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 379
I + ++ + + + L E+ + V L +L+ Q F
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE---KKQRKFD 1454
Query: 380 TLYSHGSAIS----------ESKIREFEVET--------ERLNSRIEHLKSQNDLLTITL 421
L + IS E++ RE E + E L ++ E L+ N +L +
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEM 1513
Query: 422 EECKSNAERMSMLVGKYESNATAL-------RLALQYSEQCIEAYELLLALAESEQSLIL 474
E+ S+ + + V + E + AL + L+ E ++A E E +
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 475 GQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAK------ALLMKLDGSCGGAF 528
GQF D+ +E Q+ ++ H+ E+ K A KL+G
Sbjct: 1574 GQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 529 AVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTML 588
A +++ E ++ + ++KD+ ++L++ RA+
Sbjct: 1631 LQADSAIKGREEAIKQ-----------------LRKLQAQMKDFQRELEDARAS------ 1667
Query: 589 ELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEM--AELKAQLYLLEKEKKAL 646
+ I + K + L +LM ++E++ AE + LEKE+ A
Sbjct: 1668 -RDEIFATAKENEKKAKS-----------LEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 647 EL--KLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPA 704
EL LS R A + +E +++EE+ E+ ++ + S D+ K A +
Sbjct: 1716 ELASSLSGRNALQDEKR-RLEARIAQLEEELEEEQGNMEAMS----DRVRKATQQAEQLS 1770
Query: 705 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAE 760
LA R+T +NE A + R+ K+L++++ E+ A++ KS+ E + Q E
Sbjct: 1771 NELATERSTAQKNESARQ--QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 761 FVNDLKRANSNLVAAYEKAKKKHQNKL------KKLESQMMAMVERHETQVRMLKQRIAL 814
V R + ++ KK + L +K+ Q E+ +V+ LK+++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 815 LEEENSRPHTNETSL 829
EEE+ R + N L
Sbjct: 1889 AEEESQRINANRRKL 1903
Score = 65.1 bits (157), Expect = 3e-10
Identities = 143/784 (18%), Positives = 298/784 (38%), Gaps = 78/784 (9%)
Query: 16 ELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTT 75
E+ + H+ A+ L + + + ++ + LEK+ A E L + ++V+ +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 76 LRYEERITELHSVI-------AELNKKIDRLQ--------------GTTIREEDEYSELR 114
+ E ++ EL S AELN K+ +LQ G I+ + + L
Sbjct: 1256 -KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 115 SELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLE-NVV 173
S+L +Q + E++R T + E + + +D + L+R ++ L +
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 174 CGRKKSSCSLSVAEV--------DRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLA 225
+KK S E + IE LT E A +E+ + L ++L +
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 226 EERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQ 285
+ + +++L E+ + L ++E+ ++ A +ERDR RE +T+
Sbjct: 1435 DLDN--QRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRAEAEAREKETKAL 1486
Query: 286 SVQAT---GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS 342
S+ + L TN+ + +L +S + ++ + + +T+ E +
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 343 DRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETER 402
L E+ + + L ++Q ++ F+ +E K R+ + +
Sbjct: 1547 QLEELEDELQA---TEDAKLRLEVNMQA---LKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 403 LNSRIEHLKSQNDLLTITLEECKSNAERM-----SMLVGKYESNATALRLALQYSEQCIE 457
+ +E + Q L ++ + + + + S + G+ E+ +L Q +
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF--- 1657
Query: 458 AYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALL 517
EL A A ++ + S D + + L A RK A+ + L
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLM---QLQEDLAAAERARKQADLEKEELA 1714
Query: 518 MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK 577
+L S G A+ L + + E + ++ +QL
Sbjct: 1715 EELASSLSGRNALQ----DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 578 NDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAV---LMQELMAMKEEMAELKA 634
N+ A + T + ES + + R S+ ++E AV + A++ ++A+L+
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELR--SKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 635 QLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG 694
Q+ +EK+A L ++ + + L+ +E + E+ KEQ + ++ K
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ------AEKGNARVKQL 1882
Query: 695 KECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIR 754
K + A R + +L E A + + V L S L R ++S +
Sbjct: 1883 KRQLEEAEE----ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVP 1938
Query: 755 HQQS 758
++S
Sbjct: 1939 SRRS 1942
Score = 58.9 bits (141), Expect = 2e-08
Identities = 89/463 (19%), Positives = 181/463 (39%), Gaps = 63/463 (13%)
Query: 5 VAMKYGND---SSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQS 61
++ KY ++ + AE E + AL+ L + L++ ++ LE+ + E
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALS--------LARALEEALEAKEELERTNKMLKAEME 1514
Query: 62 HLMREHEDVQ------ERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 115
L+ +DV E++ E ++ E+ + + EL ++ + +R E L+
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 116 ELS---QSQHEVNEDSRSMDQDQ-----TSVSIPENQSTMVTADMD----NCSDLNSELQ 163
+ Q++ E NE+ R Q Q T + Q + A + DL +
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 164 RVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN 223
+ G E + +K + + R +E + + K E+ L DL
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMK--DFQRELEDARASRDEIFATAKENEKKAKSLEADLM-Q 1691
Query: 224 LAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTR 283
L E+ + E+ E E L EEL + + NA+++E+ RL R+ +L+
Sbjct: 1692 LQEDLAAAERARKQADLEKEELA-------EELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 284 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 343
L+ Q + R+ + + EL+T S+ + R +L + E S
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1801
Query: 344 RPVLGSEISSI-----GVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIR---- 394
+ G+ S + + +A+ Q+ Q ++L + E ++
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 395 -----EFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMS 432
+++ + E+ N+R++ LK Q LEE + ++R++
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQ-------LEEAEEESQRIN 1897
Score = 55.1 bits (131), Expect = 3e-07
Identities = 120/615 (19%), Positives = 226/615 (36%), Gaps = 84/615 (13%)
Query: 208 TVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESL--------------TAMLCSKE 253
T +E E D E + + E EL L +++ L T + E
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 254 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTG--- 310
E R A + E + R+ E + R Q +QA ++ +
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 311 ELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQD 370
+L + + I K+ + + + ++ S +R +L IS + + + E A +L
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 371 CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAER 430
N H S ISE ++R + E R +E LK + + +A
Sbjct: 1028 LKN---------KHESMISELEVRLKKEEKSR--QELEKLK----------RKLEGDASD 1066
Query: 431 MSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQS 490
+ ++ L++ L E+ EL ALA + + + G S
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEE-----ELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 491 GDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTT 550
++ + L R AE + L +L+ + ++L S T+T
Sbjct: 1122 ---DLQEDLDSERAARNKAEKQKRDLGEELE----------ALKTELEDTLDS---TATQ 1165
Query: 551 SSTASSCDTEFT------KEDEQRLKDYIQQLKNDRA-AVKLTMLELESIHIDPLSYDVK 603
+ + E T E+ + + +Q+++ A AV+ +LE + D
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-- 1223
Query: 604 PRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH 663
+ Q L+ ENA L EL + + E++ + LE + + L+ K S E
Sbjct: 1224 --KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281
Query: 664 IEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL--RTTCSENELAA 721
+ L++EVE + + + + G K K+ A +S EL T + ++
Sbjct: 1282 VHKLQNEVES-----VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1336
Query: 722 EFTNAIRREKKLKARVQELVSA---LERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEK 778
+ L+ ++ E + A LER + I+ S + + D ++ V A E+
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF----ASTVEALEE 1392
Query: 779 AKKKHQNKLKKLESQ 793
KK+ Q +++ L Q
Sbjct: 1393 GKKRFQKEIENLTQQ 1407
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 84.7 bits (208), Expect = 3e-16
Identities = 170/903 (18%), Positives = 350/903 (38%), Gaps = 143/903 (15%)
Query: 29 KGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSV 88
+ ++ EL ++ Q E++LL+++L ++ L E E+++ R + +E LH +
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQA----ETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 89 IAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMV 148
A L ++ DR Q + + E ++ ++ + ++ E+ + + Q E + +
Sbjct: 935 EARLEEEEDRGQ----QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990
Query: 149 TADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASE-------H 201
++ D N++L + LE + S + ++AE + + LT
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERI-----SDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 202 CDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 261
++ +K E+ L + L L + S + +++A L+ + L L KEEEL A
Sbjct: 1046 LEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 262 TMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDI 321
++ +++ +++REL+ + +Q S + EL + +
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 322 PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVS--------SSVAEHLAHSLQDC-- 371
+ A + +L R + + + L E S + E L L+
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 372 --SNIQEIFQTLYSHGSAIS---------------------------ESKIREFEVETER 402
+N+ + QTL + ++ +SK + E
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 403 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 462
LN ++ L+++ + +T L E + A +++ V S + LQ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 463 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 522
L E E++ + Q Q+ + +I+ + + D +K ++ A + +G
Sbjct: 1345 LRQLEEERNSLQDQLDE----EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 523 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA 582
+ + Q E ++ T + +Q L D + L N R
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL-----------QQELDDLVVDLDNQRQL 1449
Query: 583 V--------KLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVL-----MQELMAMKEEM 629
V K L E +I D + R +++ + E L ++E + KEE+
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 630 AE----LKAQL--------------YLLEKEKKALELKLSTREAQ-----------EQAY 660
LKA++ + LEK K+ALE ++ + Q E A
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 661 L---VHIEHLKSEVE-------EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL 710
L V+++ LK + E EQ E++ R L + + E A A + +L
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 711 RTTCSENELAAEFT-----NAIRREKKLKARVQELVSALE-------RLTKSSEIRHQQS 758
+ EL A+ AI++ +KL+A++++ LE + +++ +++
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 759 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH---ETQVRMLKQRIALL 815
DL + +L AA E+A+K+ + ++L ++ + + + + R L+ RIA L
Sbjct: 1690 KSLEADLMQLQEDLAAA-ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 816 EEE 818
EEE
Sbjct: 1749 EEE 1751
Score = 83.6 bits (205), Expect = 7e-16
Identities = 156/874 (17%), Positives = 340/874 (38%), Gaps = 100/874 (11%)
Query: 23 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEE 80
A + L+ +I+ ++ + + +ER LLE++++ ++L E E + T L ++E
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDL---TTNLAEEEEKAKNLTKLKNKHES 1041
Query: 81 RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSI 140
I+EL + + K L+ + E + S+ +++ Q ++ E + + + +
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101
Query: 141 PENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK--KSSCSLSVAEVDRHIEQLTTA 198
+ A +N EL+ ++ L+ + + ++ ++ +E L T
Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Query: 199 SEHCDLAIKTVEEIEGVLGRD---LYPNLAEERSRWEKELAGLREENESLTAMLCSKEEE 255
E + T +E+ ++ L L EE E ++ +R+++ L + E+
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 256 LNRTKATMN------------------AIREERDRLRRRVRELQTRLQSVQATGPSSPGR 297
R KA ++ + + + + + ++L+ ++Q +Q+
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 298 LTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI-SSIGV 356
N ++ E+ + + + K + K + S + +L E + V
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 357 SSSV--AEHLAHSLQD-CSNIQEIFQTLYSHGSAI------SESKIREFEVETERLNSRI 407
S+ + E +SLQD E Q L H S + S+ K+++F E L
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 408 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCI-------EAYE 460
+ + + + LT EE + +++ + + L + L Q + ++
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 461 LLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKL 520
LLA E S R + ++ ++ + L+ A + ++ E K L ++
Sbjct: 1462 QLLA-EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 521 DGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDR 580
+ V + + N H S A E K + L+D +Q ++ +
Sbjct: 1521 ED-----------LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 581 AAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE 640
+++ M L+ D++ R + + + L ++L + E+ + + Q L
Sbjct: 1570 LRLEVNMQALKG----QFERDLQARDEQN--EEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 641 KEKKALELKLSTREAQEQAYL--------------VHIEHLKSEVEEQKEQRMRSLSSTS 686
KK LE L E Q + + ++ + E+E+ + R ++
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 687 SGSKDKPG--------KECADAASPALSLAELRTTCSENELAAEFT--NAIRREK-KLKA 735
K +E AA A A+L ELA+ + NA++ EK +L+A
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 736 RVQELVSALE-----------RLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQ 784
R+ +L LE R+ K+++ Q S E + A N +A ++ +++++
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN-ESARQQLERQNK 1802
Query: 785 NKLKKLESQMMAMVERHETQVRMLKQRIALLEEE 818
KL A+ + ++ + L+ +IA LEE+
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Score = 82.4 bits (202), Expect = 2e-15
Identities = 177/855 (20%), Positives = 332/855 (38%), Gaps = 114/855 (13%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+ L+G I +L + L R+ EK+ E L E ED + T + E R +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR-AK 1178
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
+ L K +D T E + E+R + +Q+ E+ E + ++ +N+
Sbjct: 1179 REQEVTVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKANLDKNK 1233
Query: 145 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA-SEHCD 203
T+ + D +L RVL G KK V E+ A +E D
Sbjct: 1234 QTLEKENADLAGEL-----RVL-GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 204 LAIKTVEEIEGVLGRDLYPNLAEERS-RWEKELAGLREENESLTAMLCSKEEELNRTKAT 262
K E+E V G N AE ++ + K++A L + + +L + +
Sbjct: 1288 KVHKLQNEVESVTG---MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 263 MNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPIN--PSTGE-LSTSSSSN 319
+ + EER+ L+ ++ E Q+++ + +L+ + + + ST E L
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 320 DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 379
I + ++ + + + L E+ + V L +L+ Q F
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE---KKQRKFD 1461
Query: 380 TLYSHGSAIS----------ESKIREFEVET--------ERLNSRIEHLKSQNDLLTITL 421
L + IS E++ RE E + E L ++ E L+ N +L +
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEM 1520
Query: 422 EECKSNAERMSMLVGKYESNATAL-------RLALQYSEQCIEAYELLLALAESEQSLIL 474
E+ S+ + + V + E + AL + L+ E ++A E E +
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 475 GQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAK------ALLMKLDGSCGGAF 528
GQF D+ +E Q+ ++ H+ E+ K A KL+G
Sbjct: 1581 GQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 529 AVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTML 588
A +++ E ++ + ++KD+ ++L++ RA+
Sbjct: 1638 LQADSAIKGREEAIKQ-----------------LRKLQAQMKDFQRELEDARAS------ 1674
Query: 589 ELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEM--AELKAQLYLLEKEKKAL 646
+ I + K + L +LM ++E++ AE + LEKE+ A
Sbjct: 1675 -RDEIFATAKENEKKAKS-----------LEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 647 EL--KLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPA 704
EL LS R A + +E +++EE+ E+ ++ + S D+ K A +
Sbjct: 1723 ELASSLSGRNALQDEKR-RLEARIAQLEEELEEEQGNMEAMS----DRVRKATQQAEQLS 1777
Query: 705 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAE 760
LA R+T +NE A + R+ K+L++++ E+ A++ KS+ E + Q E
Sbjct: 1778 NELATERSTAQKNESARQ--QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 761 FVNDLKRANSNLVAAYEKAKKKHQNKL------KKLESQMMAMVERHETQVRMLKQRIAL 814
V R + ++ KK + L +K+ Q E+ +V+ LK+++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 815 LEEENSRPHTNETSL 829
EEE+ R + N L
Sbjct: 1896 AEEESQRINANRRKL 1910
Score = 65.1 bits (157), Expect = 3e-10
Identities = 143/784 (18%), Positives = 298/784 (38%), Gaps = 78/784 (9%)
Query: 16 ELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTT 75
E+ + H+ A+ L + + + ++ + LEK+ A E L + ++V+ +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 76 LRYEERITELHSVI-------AELNKKIDRLQ--------------GTTIREEDEYSELR 114
+ E ++ EL S AELN K+ +LQ G I+ + + L
Sbjct: 1263 -KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 115 SELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLE-NVV 173
S+L +Q + E++R T + E + + +D + L+R ++ L +
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 174 CGRKKSSCSLSVAEV--------DRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLA 225
+KK S E + IE LT E A +E+ + L ++L +
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 226 EERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQ 285
+ + +++L E+ + L ++E+ ++ A +ERDR RE +T+
Sbjct: 1442 DLDN--QRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRAEAEAREKETKAL 1493
Query: 286 SVQAT---GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS 342
S+ + L TN+ + +L +S + ++ + + +T+ E +
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 343 DRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETER 402
L E+ + + L ++Q ++ F+ +E K R+ + +
Sbjct: 1554 QLEELEDELQA---TEDAKLRLEVNMQA---LKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 403 LNSRIEHLKSQNDLLTITLEECKSNAERM-----SMLVGKYESNATALRLALQYSEQCIE 457
+ +E + Q L ++ + + + + S + G+ E+ +L Q +
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF--- 1664
Query: 458 AYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALL 517
EL A A ++ + S D + + L A RK A+ + L
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLM---QLQEDLAAAERARKQADLEKEELA 1721
Query: 518 MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK 577
+L S G A+ L + + E + ++ +QL
Sbjct: 1722 EELASSLSGRNALQ----DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 578 NDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAV---LMQELMAMKEEMAELKA 634
N+ A + T + ES + + R S+ ++E AV + A++ ++A+L+
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELR--SKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 635 QLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG 694
Q+ +EK+A L ++ + + L+ +E + E+ KEQ + ++ K
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ------AEKGNARVKQL 1889
Query: 695 KECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIR 754
K + A R + +L E A + + V L S L R ++S +
Sbjct: 1890 KRQLEEAEE----ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVP 1945
Query: 755 HQQS 758
++S
Sbjct: 1946 SRRS 1949
Score = 58.9 bits (141), Expect = 2e-08
Identities = 89/463 (19%), Positives = 181/463 (39%), Gaps = 63/463 (13%)
Query: 5 VAMKYGND---SSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQS 61
++ KY ++ + AE E + AL+ L + L++ ++ LE+ + E
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALS--------LARALEEALEAKEELERTNKMLKAEME 1521
Query: 62 HLMREHEDVQ------ERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 115
L+ +DV E++ E ++ E+ + + EL ++ + +R E L+
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 116 ELS---QSQHEVNEDSRSMDQDQ-----TSVSIPENQSTMVTADMD----NCSDLNSELQ 163
+ Q++ E NE+ R Q Q T + Q + A + DL +
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 164 RVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN 223
+ G E + +K + + R +E + + K E+ L DL
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMK--DFQRELEDARASRDEIFATAKENEKKAKSLEADLM-Q 1698
Query: 224 LAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTR 283
L E+ + E+ E E L EEL + + NA+++E+ RL R+ +L+
Sbjct: 1699 LQEDLAAAERARKQADLEKEELA-------EELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 284 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 343
L+ Q + R+ + + EL+T S+ + R +L + E S
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1808
Query: 344 RPVLGSEISSI-----GVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIR---- 394
+ G+ S + + +A+ Q+ Q ++L + E ++
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 395 -----EFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMS 432
+++ + E+ N+R++ LK Q LEE + ++R++
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQ-------LEEAEEESQRIN 1904
Score = 55.1 bits (131), Expect = 3e-07
Identities = 120/615 (19%), Positives = 226/615 (36%), Gaps = 84/615 (13%)
Query: 208 TVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESL--------------TAMLCSKE 253
T +E E D E + + E EL L +++ L T + E
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 254 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTG--- 310
E R A + E + R+ E + R Q +QA ++ +
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 311 ELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQD 370
+L + + I K+ + + + ++ S +R +L IS + + + E A +L
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 371 CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAER 430
N H S ISE ++R + E R +E LK + + +A
Sbjct: 1035 LKN---------KHESMISELEVRLKKEEKSR--QELEKLK----------RKLEGDASD 1073
Query: 431 MSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQS 490
+ ++ L++ L E+ EL ALA + + + G S
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEE-----ELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 491 GDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTT 550
++ + L R AE + L +L+ + ++L S T+T
Sbjct: 1129 ---DLQEDLDSERAARNKAEKQKRDLGEELE----------ALKTELEDTLDS---TATQ 1172
Query: 551 SSTASSCDTEFT------KEDEQRLKDYIQQLKNDRA-AVKLTMLELESIHIDPLSYDVK 603
+ + E T E+ + + +Q+++ A AV+ +LE + D
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-- 1230
Query: 604 PRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH 663
+ Q L+ ENA L EL + + E++ + LE + + L+ K S E
Sbjct: 1231 --KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 664 IEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL--RTTCSENELAA 721
+ L++EVE + + + + G K K+ A +S EL T + ++
Sbjct: 1289 VHKLQNEVES-----VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1343
Query: 722 EFTNAIRREKKLKARVQELVSA---LERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEK 778
+ L+ ++ E + A LER + I+ S + + D ++ V A E+
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF----ASTVEALEE 1399
Query: 779 AKKKHQNKLKKLESQ 793
KK+ Q +++ L Q
Sbjct: 1400 GKKRFQKEIENLTQQ 1414
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 84.7 bits (208), Expect = 3e-16
Identities = 170/903 (18%), Positives = 350/903 (38%), Gaps = 143/903 (15%)
Query: 29 KGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSV 88
+ ++ EL ++ Q E++LL+++L ++ L E E+++ R + +E LH +
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQA----ETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 89 IAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMV 148
A L ++ DR Q + + E ++ ++ + ++ E+ + + Q E + +
Sbjct: 935 EARLEEEEDRGQ----QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990
Query: 149 TADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASE-------H 201
++ D N++L + LE + S + ++AE + + LT
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERI-----SDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 202 CDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 261
++ +K E+ L + L L + S + +++A L+ + L L KEEEL A
Sbjct: 1046 LEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 262 TMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDI 321
++ +++ +++REL+ + +Q S + EL + +
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 322 PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVS--------SSVAEHLAHSLQDC-- 371
+ A + +L R + + + L E S + E L L+
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 372 --SNIQEIFQTLYSHGSAIS---------------------------ESKIREFEVETER 402
+N+ + QTL + ++ +SK + E
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 403 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 462
LN ++ L+++ + +T L E + A +++ V S + LQ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 463 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 522
L E E++ + Q Q+ + +I+ + + D +K ++ A + +G
Sbjct: 1345 LRQLEEERNSLQDQLDE----EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 523 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA 582
+ + Q E ++ T + +Q L D + L N R
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL-----------QQELDDLVVDLDNQRQL 1449
Query: 583 V--------KLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVL-----MQELMAMKEEM 629
V K L E +I D + R +++ + E L ++E + KEE+
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 630 AE----LKAQL--------------YLLEKEKKALELKLSTREAQ-----------EQAY 660
LKA++ + LEK K+ALE ++ + Q E A
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 661 L---VHIEHLKSEVE-------EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL 710
L V+++ LK + E EQ E++ R L + + E A A + +L
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 711 RTTCSENELAAEFT-----NAIRREKKLKARVQELVSALE-------RLTKSSEIRHQQS 758
+ EL A+ AI++ +KL+A++++ LE + +++ +++
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 759 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH---ETQVRMLKQRIALL 815
DL + +L AA E+A+K+ + ++L ++ + + + + R L+ RIA L
Sbjct: 1690 KSLEADLMQLQEDLAAA-ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 816 EEE 818
EEE
Sbjct: 1749 EEE 1751
Score = 83.6 bits (205), Expect = 7e-16
Identities = 156/874 (17%), Positives = 340/874 (38%), Gaps = 100/874 (11%)
Query: 23 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEE 80
A + L+ +I+ ++ + + +ER LLE++++ ++L E E + T L ++E
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDL---TTNLAEEEEKAKNLTKLKNKHES 1041
Query: 81 RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSI 140
I+EL + + K L+ + E + S+ +++ Q ++ E + + + +
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101
Query: 141 PENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK--KSSCSLSVAEVDRHIEQLTTA 198
+ A +N EL+ ++ L+ + + ++ ++ +E L T
Sbjct: 1102 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Query: 199 SEHCDLAIKTVEEIEGVLGRD---LYPNLAEERSRWEKELAGLREENESLTAMLCSKEEE 255
E + T +E+ ++ L L EE E ++ +R+++ L + E+
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 256 LNRTKATMN------------------AIREERDRLRRRVRELQTRLQSVQATGPSSPGR 297
R KA ++ + + + + + ++L+ ++Q +Q+
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 298 LTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI-SSIGV 356
N ++ E+ + + + K + K + S + +L E + V
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 357 SSSV--AEHLAHSLQD-CSNIQEIFQTLYSHGSAI------SESKIREFEVETERLNSRI 407
S+ + E +SLQD E Q L H S + S+ K+++F E L
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 408 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCI-------EAYE 460
+ + + + LT EE + +++ + + L + L Q + ++
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 461 LLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKL 520
LLA E S R + ++ ++ + L+ A + ++ E K L ++
Sbjct: 1462 QLLA-EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 521 DGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDR 580
+ V + + N H S A E K + L+D +Q ++ +
Sbjct: 1521 ED-----------LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 581 AAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE 640
+++ M L+ D++ R + + + L ++L + E+ + + Q L
Sbjct: 1570 LRLEVNMQALKG----QFERDLQARDEQN--EEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 641 KEKKALELKLSTREAQEQAYL--------------VHIEHLKSEVEEQKEQRMRSLSSTS 686
KK LE L E Q + + ++ + E+E+ + R ++
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 687 SGSKDKPG--------KECADAASPALSLAELRTTCSENELAAEFT--NAIRREK-KLKA 735
K +E AA A A+L ELA+ + NA++ EK +L+A
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 736 RVQELVSALE-----------RLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQ 784
R+ +L LE R+ K+++ Q S E + A N +A ++ +++++
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN-ESARQQLERQNK 1802
Query: 785 NKLKKLESQMMAMVERHETQVRMLKQRIALLEEE 818
KL A+ + ++ + L+ +IA LEE+
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Score = 82.4 bits (202), Expect = 2e-15
Identities = 177/855 (20%), Positives = 332/855 (38%), Gaps = 114/855 (13%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+ L+G I +L + L R+ EK+ E L E ED + T + E R +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR-AK 1178
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
+ L K +D T E + E+R + +Q+ E+ E + ++ +N+
Sbjct: 1179 REQEVTVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKANLDKNK 1233
Query: 145 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA-SEHCD 203
T+ + D +L RVL G KK V E+ A +E D
Sbjct: 1234 QTLEKENADLAGEL-----RVL-GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 204 LAIKTVEEIEGVLGRDLYPNLAEERS-RWEKELAGLREENESLTAMLCSKEEELNRTKAT 262
K E+E V G N AE ++ + K++A L + + +L + +
Sbjct: 1288 KVHKLQNEVESVTG---MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 263 MNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPIN--PSTGE-LSTSSSSN 319
+ + EER+ L+ ++ E Q+++ + +L+ + + + ST E L
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 320 DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 379
I + ++ + + + L E+ + V L +L+ Q F
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE---KKQRKFD 1461
Query: 380 TLYSHGSAIS----------ESKIREFEVET--------ERLNSRIEHLKSQNDLLTITL 421
L + IS E++ RE E + E L ++ E L+ N +L +
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEM 1520
Query: 422 EECKSNAERMSMLVGKYESNATAL-------RLALQYSEQCIEAYELLLALAESEQSLIL 474
E+ S+ + + V + E + AL + L+ E ++A E E +
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 475 GQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAK------ALLMKLDGSCGGAF 528
GQF D+ +E Q+ ++ H+ E+ K A KL+G
Sbjct: 1581 GQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 529 AVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTML 588
A +++ E ++ + ++KD+ ++L++ RA+
Sbjct: 1638 LQADSAIKGREEAIKQ-----------------LRKLQAQMKDFQRELEDARAS------ 1674
Query: 589 ELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEM--AELKAQLYLLEKEKKAL 646
+ I + K + L +LM ++E++ AE + LEKE+ A
Sbjct: 1675 -RDEIFATAKENEKKAKS-----------LEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 647 EL--KLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPA 704
EL LS R A + +E +++EE+ E+ ++ + S D+ K A +
Sbjct: 1723 ELASSLSGRNALQDEKR-RLEARIAQLEEELEEEQGNMEAMS----DRVRKATQQAEQLS 1777
Query: 705 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAE 760
LA R+T +NE A + R+ K+L++++ E+ A++ KS+ E + Q E
Sbjct: 1778 NELATERSTAQKNESARQ--QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 761 FVNDLKRANSNLVAAYEKAKKKHQNKL------KKLESQMMAMVERHETQVRMLKQRIAL 814
V R + ++ KK + L +K+ Q E+ +V+ LK+++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 815 LEEENSRPHTNETSL 829
EEE+ R + N L
Sbjct: 1896 AEEESQRINANRRKL 1910
Score = 58.9 bits (141), Expect = 2e-08
Identities = 89/463 (19%), Positives = 181/463 (39%), Gaps = 63/463 (13%)
Query: 5 VAMKYGND---SSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQS 61
++ KY ++ + AE E + AL+ L + L++ ++ LE+ + E
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALS--------LARALEEALEAKEELERTNKMLKAEME 1521
Query: 62 HLMREHEDVQ------ERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 115
L+ +DV E++ E ++ E+ + + EL ++ + +R E L+
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 116 ELS---QSQHEVNEDSRSMDQDQ-----TSVSIPENQSTMVTADMD----NCSDLNSELQ 163
+ Q++ E NE+ R Q Q T + Q + A + DL +
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 164 RVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN 223
+ G E + +K + + R +E + + K E+ L DL
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMK--DFQRELEDARASRDEIFATAKENEKKAKSLEADLM-Q 1698
Query: 224 LAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTR 283
L E+ + E+ E E L EEL + + NA+++E+ RL R+ +L+
Sbjct: 1699 LQEDLAAAERARKQADLEKEELA-------EELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 284 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 343
L+ Q + R+ + + EL+T S+ + R +L + E S
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1808
Query: 344 RPVLGSEISSI-----GVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIR---- 394
+ G+ S + + +A+ Q+ Q ++L + E ++
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 395 -----EFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMS 432
+++ + E+ N+R++ LK Q LEE + ++R++
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQ-------LEEAEEESQRIN 1904
Score = 55.1 bits (131), Expect = 3e-07
Identities = 120/615 (19%), Positives = 226/615 (36%), Gaps = 84/615 (13%)
Query: 208 TVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESL--------------TAMLCSKE 253
T +E E D E + + E EL L +++ L T + E
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 254 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTG--- 310
E R A + E + R+ E + R Q +QA ++ +
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 311 ELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQD 370
+L + + I K+ + + + ++ S +R +L IS + + + E A +L
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 371 CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAER 430
N H S ISE ++R + E R +E LK + + +A
Sbjct: 1035 LKN---------KHESMISELEVRLKKEEKSR--QELEKLK----------RKLEGDASD 1073
Query: 431 MSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQS 490
+ ++ L++ L E+ EL ALA + + + G S
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEE-----ELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 491 GDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTT 550
++ + L R AE + L +L+ + ++L S T+T
Sbjct: 1129 ---DLQEDLDSERAARNKAEKQKRDLGEELE----------ALKTELEDTLDS---TATQ 1172
Query: 551 SSTASSCDTEFT------KEDEQRLKDYIQQLKNDRA-AVKLTMLELESIHIDPLSYDVK 603
+ + E T E+ + + +Q+++ A AV+ +LE + D
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-- 1230
Query: 604 PRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH 663
+ Q L+ ENA L EL + + E++ + LE + + L+ K S E
Sbjct: 1231 --KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 664 IEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL--RTTCSENELAA 721
+ L++EVE + + + + G K K+ A +S EL T + ++
Sbjct: 1289 VHKLQNEVES-----VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1343
Query: 722 EFTNAIRREKKLKARVQELVSA---LERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEK 778
+ L+ ++ E + A LER + I+ S + + D ++ V A E+
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF----ASTVEALEE 1399
Query: 779 AKKKHQNKLKKLESQ 793
KK+ Q +++ L Q
Sbjct: 1400 GKKRFQKEIENLTQQ 1414
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 84.7 bits (208), Expect = 3e-16
Identities = 170/903 (18%), Positives = 350/903 (38%), Gaps = 143/903 (15%)
Query: 29 KGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSV 88
+ ++ EL ++ Q E++LL+++L ++ L E E+++ R + +E LH +
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQA----ETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 89 IAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMV 148
A L ++ DR Q + + E ++ ++ + ++ E+ + + Q E + +
Sbjct: 928 EARLEEEEDRGQ----QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983
Query: 149 TADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASE-------H 201
++ D N++L + LE + S + ++AE + + LT
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERI-----SDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 202 CDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 261
++ +K E+ L + L L + S + +++A L+ + L L KEEEL A
Sbjct: 1039 LEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 262 TMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDI 321
++ +++ +++REL+ + +Q S + EL + +
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 322 PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVS--------SSVAEHLAHSLQDC-- 371
+ A + +L R + + + L E S + E L L+
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 372 --SNIQEIFQTLYSHGSAIS---------------------------ESKIREFEVETER 402
+N+ + QTL + ++ +SK + E
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 403 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELL 462
LN ++ L+++ + +T L E + A +++ V S + LQ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 463 LALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDG 522
L E E++ + Q Q+ + +I+ + + D +K ++ A + +G
Sbjct: 1338 LRQLEEERNSLQDQLDE----EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 523 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA 582
+ + Q E ++ T + +Q L D + L N R
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL-----------QQELDDLVVDLDNQRQL 1442
Query: 583 V--------KLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVL-----MQELMAMKEEM 629
V K L E +I D + R +++ + E L ++E + KEE+
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 630 AE----LKAQL--------------YLLEKEKKALELKLSTREAQ-----------EQAY 660
LKA++ + LEK K+ALE ++ + Q E A
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 661 L---VHIEHLKSEVE-------EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL 710
L V+++ LK + E EQ E++ R L + + E A A + +L
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 711 RTTCSENELAAEFT-----NAIRREKKLKARVQELVSALE-------RLTKSSEIRHQQS 758
+ EL A+ AI++ +KL+A++++ LE + +++ +++
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 759 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH---ETQVRMLKQRIALL 815
DL + +L AA E+A+K+ + ++L ++ + + + + R L+ RIA L
Sbjct: 1683 KSLEADLMQLQEDLAAA-ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 816 EEE 818
EEE
Sbjct: 1742 EEE 1744
Score = 83.6 bits (205), Expect = 7e-16
Identities = 156/874 (17%), Positives = 340/874 (38%), Gaps = 100/874 (11%)
Query: 23 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEE 80
A + L+ +I+ ++ + + +ER LLE++++ ++L E E + T L ++E
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDL---TTNLAEEEEKAKNLTKLKNKHES 1034
Query: 81 RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSI 140
I+EL + + K L+ + E + S+ +++ Q ++ E + + + +
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1094
Query: 141 PENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK--KSSCSLSVAEVDRHIEQLTTA 198
+ A +N EL+ ++ L+ + + ++ ++ +E L T
Sbjct: 1095 ALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Query: 199 SEHCDLAIKTVEEIEGVLGRD---LYPNLAEERSRWEKELAGLREENESLTAMLCSKEEE 255
E + T +E+ ++ L L EE E ++ +R+++ L + E+
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 256 LNRTKATMN------------------AIREERDRLRRRVRELQTRLQSVQATGPSSPGR 297
R KA ++ + + + + + ++L+ ++Q +Q+
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 298 LTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI-SSIGV 356
N ++ E+ + + + K + K + S + +L E + V
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 357 SSSV--AEHLAHSLQD-CSNIQEIFQTLYSHGSAI------SESKIREFEVETERLNSRI 407
S+ + E +SLQD E Q L H S + S+ K+++F E L
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 408 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCI-------EAYE 460
+ + + + LT EE + +++ + + L + L Q + ++
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 461 LLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKL 520
LLA E S R + ++ ++ + L+ A + ++ E K L ++
Sbjct: 1455 QLLA-EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 521 DGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDR 580
+ V + + N H S A E K + L+D +Q ++ +
Sbjct: 1514 ED-----------LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 581 AAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE 640
+++ M L+ D++ R + + + L ++L + E+ + + Q L
Sbjct: 1563 LRLEVNMQALKG----QFERDLQARDEQN--EEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 641 KEKKALELKLSTREAQEQAYL--------------VHIEHLKSEVEEQKEQRMRSLSSTS 686
KK LE L E Q + + ++ + E+E+ + R ++
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 687 SGSKDKPG--------KECADAASPALSLAELRTTCSENELAAEFT--NAIRREK-KLKA 735
K +E AA A A+L ELA+ + NA++ EK +L+A
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 736 RVQELVSALE-----------RLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQ 784
R+ +L LE R+ K+++ Q S E + A N +A ++ +++++
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN-ESARQQLERQNK 1795
Query: 785 NKLKKLESQMMAMVERHETQVRMLKQRIALLEEE 818
KL A+ + ++ + L+ +IA LEE+
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Score = 82.4 bits (202), Expect = 2e-15
Identities = 177/855 (20%), Positives = 332/855 (38%), Gaps = 114/855 (13%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+ L+G I +L + L R+ EK+ E L E ED + T + E R +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR-AK 1171
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
+ L K +D T E + E+R + +Q+ E+ E + ++ +N+
Sbjct: 1172 REQEVTVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKANLDKNK 1226
Query: 145 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA-SEHCD 203
T+ + D +L RVL G KK V E+ A +E D
Sbjct: 1227 QTLEKENADLAGEL-----RVL-GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 204 LAIKTVEEIEGVLGRDLYPNLAEERS-RWEKELAGLREENESLTAMLCSKEEELNRTKAT 262
K E+E V G N AE ++ + K++A L + + +L + +
Sbjct: 1281 KVHKLQNEVESVTG---MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 263 MNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPIN--PSTGE-LSTSSSSN 319
+ + EER+ L+ ++ E Q+++ + +L+ + + + ST E L
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 320 DIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQ 379
I + ++ + + + L E+ + V L +L+ Q F
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE---KKQRKFD 1454
Query: 380 TLYSHGSAIS----------ESKIREFEVET--------ERLNSRIEHLKSQNDLLTITL 421
L + IS E++ RE E + E L ++ E L+ N +L +
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEM 1513
Query: 422 EECKSNAERMSMLVGKYESNATAL-------RLALQYSEQCIEAYELLLALAESEQSLIL 474
E+ S+ + + V + E + AL + L+ E ++A E E +
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 475 GQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAK------ALLMKLDGSCGGAF 528
GQF D+ +E Q+ ++ H+ E+ K A KL+G
Sbjct: 1574 GQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 529 AVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTML 588
A +++ E ++ + ++KD+ ++L++ RA+
Sbjct: 1631 LQADSAIKGREEAIKQ-----------------LRKLQAQMKDFQRELEDARAS------ 1667
Query: 589 ELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEM--AELKAQLYLLEKEKKAL 646
+ I + K + L +LM ++E++ AE + LEKE+ A
Sbjct: 1668 -RDEIFATAKENEKKAKS-----------LEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 647 EL--KLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPA 704
EL LS R A + +E +++EE+ E+ ++ + S D+ K A +
Sbjct: 1716 ELASSLSGRNALQDEKR-RLEARIAQLEEELEEEQGNMEAMS----DRVRKATQQAEQLS 1770
Query: 705 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAE 760
LA R+T +NE A + R+ K+L++++ E+ A++ KS+ E + Q E
Sbjct: 1771 NELATERSTAQKNESARQ--QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 761 FVNDLKRANSNLVAAYEKAKKKHQNKL------KKLESQMMAMVERHETQVRMLKQRIAL 814
V R + ++ KK + L +K+ Q E+ +V+ LK+++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 815 LEEENSRPHTNETSL 829
EEE+ R + N L
Sbjct: 1889 AEEESQRINANRRKL 1903
Score = 58.9 bits (141), Expect = 2e-08
Identities = 89/463 (19%), Positives = 181/463 (39%), Gaps = 63/463 (13%)
Query: 5 VAMKYGND---SSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQS 61
++ KY ++ + AE E + AL+ L + L++ ++ LE+ + E
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALS--------LARALEEALEAKEELERTNKMLKAEME 1514
Query: 62 HLMREHEDVQ------ERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 115
L+ +DV E++ E ++ E+ + + EL ++ + +R E L+
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 116 ELS---QSQHEVNEDSRSMDQDQ-----TSVSIPENQSTMVTADMD----NCSDLNSELQ 163
+ Q++ E NE+ R Q Q T + Q + A + DL +
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 164 RVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPN 223
+ G E + +K + + R +E + + K E+ L DL
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMK--DFQRELEDARASRDEIFATAKENEKKAKSLEADLM-Q 1691
Query: 224 LAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTR 283
L E+ + E+ E E L EEL + + NA+++E+ RL R+ +L+
Sbjct: 1692 LQEDLAAAERARKQADLEKEELA-------EELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 284 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 343
L+ Q + R+ + + EL+T S+ + R +L + E S
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1801
Query: 344 RPVLGSEISSI-----GVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIR---- 394
+ G+ S + + +A+ Q+ Q ++L + E ++
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 395 -----EFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMS 432
+++ + E+ N+R++ LK Q LEE + ++R++
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQ-------LEEAEEESQRIN 1897
Score = 55.1 bits (131), Expect = 3e-07
Identities = 120/615 (19%), Positives = 226/615 (36%), Gaps = 84/615 (13%)
Query: 208 TVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESL--------------TAMLCSKE 253
T +E E D E + + E EL L +++ L T + E
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 254 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTG--- 310
E R A + E + R+ E + R Q +QA ++ +
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 311 ELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQD 370
+L + + I K+ + + + ++ S +R +L IS + + + E A +L
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 371 CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAER 430
N H S ISE ++R + E R +E LK + + +A
Sbjct: 1028 LKN---------KHESMISELEVRLKKEEKSR--QELEKLK----------RKLEGDASD 1066
Query: 431 MSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQS 490
+ ++ L++ L E+ EL ALA + + + G S
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEE-----ELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 491 GDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTT 550
++ + L R AE + L +L+ + ++L S T+T
Sbjct: 1122 ---DLQEDLDSERAARNKAEKQKRDLGEELE----------ALKTELEDTLDS---TATQ 1165
Query: 551 SSTASSCDTEFT------KEDEQRLKDYIQQLKNDRA-AVKLTMLELESIHIDPLSYDVK 603
+ + E T E+ + + +Q+++ A AV+ +LE + D
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-- 1223
Query: 604 PRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH 663
+ Q L+ ENA L EL + + E++ + LE + + L+ K S E
Sbjct: 1224 --KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281
Query: 664 IEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL--RTTCSENELAA 721
+ L++EVE + + + + G K K+ A +S EL T + ++
Sbjct: 1282 VHKLQNEVES-----VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1336
Query: 722 EFTNAIRREKKLKARVQELVSA---LERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEK 778
+ L+ ++ E + A LER + I+ S + + D ++ V A E+
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF----ASTVEALEE 1392
Query: 779 AKKKHQNKLKKLESQ 793
KK+ Q +++ L Q
Sbjct: 1393 GKKRFQKEIENLTQQ 1407
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 84.3 bits (207), Expect = 4e-16
Identities = 175/856 (20%), Positives = 344/856 (40%), Gaps = 142/856 (16%)
Query: 24 ALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERIT 83
A L+GD+ + + E ++ +E+KL K + E S L + +D Q +L+++++I
Sbjct: 1055 AKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVH-SLQFQKKIK 1113
Query: 84 ELHSVIAELNK----------KIDRLQGTTIREEDEYSELRSELS---QSQHEVNEDSRS 130
EL + I EL + KI++ + RE +E SE E S +Q E+N+ +
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173
Query: 131 ------MDQDQTSVSIPENQSTMVTADMDNCSDLNSE---LQRVLTGLENVVCGRKKSSC 181
D ++ ++ +T+ D+ ++L + LQRV LE ++KS
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLE-----KEKSEL 1228
Query: 182 SLSVAEVDRHIEQLTTASEHCDLAIKTVE-EIEGVLGRDLYPNLAEERSRWEKELAGLRE 240
+ + ++ +IE L+ + + + +TVE + + +D +K A L+
Sbjct: 1229 KMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK--ARLQT 1286
Query: 241 ENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTS 300
+N L+ + KE +++ + A+ ++ + L+R++ E +T+ ++ A S
Sbjct: 1287 QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE-ETKAKNAMAHALQSSRHDCD 1345
Query: 301 TNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSV 360
R E AK + LSK SE V+
Sbjct: 1346 LLREQYEEEQE------------AKAELQRALSKANSE-----------------VAQWR 1376
Query: 361 AEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTIT 420
++ ++Q ++E + L +++E E TE NS+ L+ L
Sbjct: 1377 TKYETDAIQRTEELEEAKKKL--------AQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
Query: 421 LEECKSNAERMSMLVGKYESNATAL-RLALQYSEQCIEAYELLLALAESEQSLILGQFRA 479
+E+ + ER + ++ ++ ++ E+ L A + +SL F+
Sbjct: 1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM 1488
Query: 480 AGVGSSPGDQ---------SGDENITQMLKRAHDCRKTAENA--AKALLMKLDGSCGGAF 528
DQ + E I+ + ++ + K + A K L+ + A
Sbjct: 1489 RNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVAL 1548
Query: 529 AVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK--NDRAAVKL- 585
S++ ES S S D + ++DE+ I+QLK + RAA L
Sbjct: 1549 EEVEGSLEHEESKILRVQLE-LSQVKSELDRKVIEKDEE-----IEQLKRNSQRAAEALQ 1602
Query: 586 TMLELE-SIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKK 644
++L+ E D L K GD +++ +L +MAE + L ++ + K
Sbjct: 1603 SVLDAEIRSRNDALRLKKKMEGDLNEMEI-------QLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 645 ALELKL-----STREAQEQAYLVHIEH--LKSEVEEQK-----EQRMRSLSSTSSGSKDK 692
+L L S + +EQ +V + L E+EE K +R R LS
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSE-------- 1707
Query: 693 PGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSE 752
+E DA+ ++ S+N T+ I +KKL+A + + + +E + S
Sbjct: 1708 --QELLDASD------RVQLLHSQN------TSLINTKKKLEADIAQCQAEVENSIQESR 1753
Query: 753 IRHQQSAEFVNDLK------RANSNLVAAYEKAKKKHQNKLKKLESQM----MAMVERHE 802
+++ + + D + + A E+ KK + +K L+ ++ ++ +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
Query: 803 TQVRMLKQRIALLEEE 818
Q++ L+ R+ LE E
Sbjct: 1814 KQIQKLENRVRELENE 1829
Score = 83.6 bits (205), Expect = 7e-16
Identities = 169/875 (19%), Positives = 335/875 (38%), Gaps = 125/875 (14%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+A++K D + L ++E R LE+K+ E++ L + + E + EER
Sbjct: 853 MATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL-MDAEERCEG 911
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
L L K+ L EE+ SEL ++ + + + R +D + +++ E +
Sbjct: 912 LIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKE 971
Query: 145 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDL 204
+ N S+ +T LE + K SL A + ++ L + +
Sbjct: 972 KHATENKVKNLSE-------EMTALEENISKLTKEKKSLQEAH-QQTLDDLQVEEDKVNG 1023
Query: 205 AIK-------TVEEIEGVLGRDLYPNLAEERSRWEKE---------LAGLREENESLTAM 248
IK +++EG L ++ ER++ + E + L + + +
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Query: 249 LCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPS 308
L KE EL++ +A ++ + + +++++ELQ R++ ++ + + +
Sbjct: 1084 LKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDL 1143
Query: 309 TGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS-----DRPVLGSEISSIGVSSSVAEH 363
EL S + + +++++K R + L E ++ + A+
Sbjct: 1144 ARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADS 1203
Query: 364 LAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL---KSQNDLLTIT 420
+A + N+Q + Q L E + E ++E + + S IE L KS + T
Sbjct: 1204 VAELGEQIDNLQRVKQKL--------EKEKSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 421 LE----ECKSNAERMSMLVGKYESNATALRLALQYSE--QCIEAYELLLALAESEQSLIL 474
+E E K+ E+ + L+ ++ N RL Q E +E E L++ + +
Sbjct: 1256 VEDQFSEIKAKDEQQTQLI--HDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 475 GQFRAAGVGSSPGDQSGDENITQMLKRAHDC-----RKTAENAAKALLMKLDGSCGGAFA 529
Q ++ + + HDC + E AKA L + A +
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR-------ALS 1366
Query: 530 VAGCSVQPWES------------------------LSSNSHTSTTSSTASSCDTEFTKED 565
A V W + + +T T +S +S + +
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE-----KT 1421
Query: 566 EQRLKDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENA-----VL 618
+QRL+ ++ L D R+ L+ + + D + + K + D + +LE A L
Sbjct: 1422 KQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL 1481
Query: 619 MQELMAMKEEMAELKAQLYLLEKEKKALELKLS---TREAQEQAYLVHIEHLKSEVEEQK 675
EL M+ E+ QL L +E K L+ ++S + A+ L E K VE++K
Sbjct: 1482 STELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK 1541
Query: 676 EQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKA 735
+L + + K + +L + ++EL + ++LK
Sbjct: 1542 SDLQVALEEVEGSLEHEESK---------ILRVQLELSQVKSELDRKVIEKDEEIEQLKR 1592
Query: 736 RVQELVSALERLTKSSEIRHQQSA-----EFVNDLKRANSNL------VAAYEKAKKKHQ 784
Q AL+ + +EIR + A + DL L +A +K + Q
Sbjct: 1593 NSQRAAEALQSVL-DAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQ 1651
Query: 785 NKLKKLESQMMAMVERHETQVRMLKQRIALLEEEN 819
+LK + + + +E LK+++A++E N
Sbjct: 1652 GQLKDSQLHLDDALRSNED----LKEQLAIVERRN 1682
Score = 82.0 bits (201), Expect = 2e-15
Identities = 175/838 (20%), Positives = 334/838 (39%), Gaps = 96/838 (11%)
Query: 26 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQ-------SHLMREHEDVQE--RTTL 76
+SLK DI +L L + E+E+ E K+ E S L +E + +QE + TL
Sbjct: 952 SSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTL 1011
Query: 77 R----YEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMD 132
E+++ L + A+L ++ D L+G+ +E+ +LR++L +++ ++ D +
Sbjct: 1012 DDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK----KLRADLERAKRKLEGD---LK 1064
Query: 133 QDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHI 192
Q S+ EN + + S+LQ + E V + E+ I
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD-EQV----HSLQFQKKIKELQARI 1119
Query: 193 EQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSK 252
E+L EEIE L + ++RS +EL + E E + ++
Sbjct: 1120 EELE-------------EEIEA--EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQ 1164
Query: 253 EEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGEL 312
E + +A +R + + + L+ QA + G + + +L
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ---KL 1221
Query: 313 STSSSSNDIPIAKIAERVK-LSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDC 371
S + I +A ++ LSK++S + R V + S I L H L
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTV-EDQFSEIKAKDEQQTQLIHDLNMQ 1280
Query: 372 SNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKS-NAER 430
+ SH ES I + + L ++E LK Q + EE K+ NA
Sbjct: 1281 KARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME------EETKAKNAMA 1334
Query: 431 MSMLVGKYESNATALRLALQYSEQCIEAYELLLAL--AESEQSLILGQFRAAGVGSSPGD 488
++ +++ + L QY E+ EL AL A SE + ++ + +
Sbjct: 1335 HALQSSRHDCDL----LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1390
Query: 489 QSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTS 548
+ + + Q L+ A + +TA N+ A L K G V+ SHT+
Sbjct: 1391 EEAKKKLAQRLQEAEENTETA-NSKCASLEKTKQRLQG-------EVEDLMRDLERSHTA 1442
Query: 549 TTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPL----SYDVKP 604
+T F K L ++ Q+L +A ++ E S+ + +Y+ +
Sbjct: 1443 --CATLDKKQRNFDKV----LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE-EV 1495
Query: 605 RGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHI 664
+ L EN L +E+ + E++AE L EK KK +E + S + + +
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 665 EHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEF- 723
EH EE K R++ S D+ E + ++ ++ L AE
Sbjct: 1556 EH-----EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR 1610
Query: 724 --TNAIRREKKLKARVQEL----------VSALERLTKSSEIRHQQSAEFVNDLKRANSN 771
+A+R +KK++ + E+ ++ ++ ++ + + + S ++D R+N +
Sbjct: 1611 SRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNED 1670
Query: 772 LVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 829
L ++++ L++LE +A+ + T+ R+ +Q + + H+ TSL
Sbjct: 1671 LKEQLAIVERRNGLLLEELEEMKVALEQTERTR-RLSEQELLDASDRVQLLHSQNTSL 1727
Score = 49.7 bits (117), Expect = 1e-05
Identities = 105/607 (17%), Positives = 220/607 (36%), Gaps = 69/607 (11%)
Query: 228 RSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 287
R E+++ L +E L + S+ E L + + + + L +V+EL RL+
Sbjct: 874 RKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEE 933
Query: 288 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 347
+ L + R + L ++ + K+ + ++ + ++ S + L
Sbjct: 934 EEMN----SELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTAL 989
Query: 348 GSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRI 407
IS + ++ ++QE Q + + +VE +++N I
Sbjct: 990 EENISKL-------------TKEKKSLQEAHQ-----------QTLDDLQVEEDKVNGLI 1025
Query: 408 E---HLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLA 464
+ L+ Q D L +LE+ K + K E + + ++ E + E L
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085
Query: 465 LAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRK--TAENAAKALLMKLDG 522
E E L Q +A + I ++ R + + AE+ +A + K
Sbjct: 1086 KKEFE----LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRS 1141
Query: 523 SCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA 582
L S +S A+S E K+ E + + L+
Sbjct: 1142 DLA-------------RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 583 VKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKE 642
+ T L D ++ + + QR+ + L +E +K E+ ++ + + L K
Sbjct: 1189 HEATAATLRKKQADSVAELGEQIDNLQRVKQK---LEKEKSELKMEIDDMASNIEALSKS 1245
Query: 643 KKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGK-----EC 697
K +E T E Q +K++ +EQ+ Q + L+ + + + G+ E
Sbjct: 1246 KSNIERTCRTVEDQ-------FSEIKAK-DEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297
Query: 698 ADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQ 757
++ L+ ++ T EL + + + + +Q + L + E +
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357
Query: 758 SAEFVNDLKRANSNLV---AAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIAL 814
AE L +ANS + YE + +L++ + ++ ++ E + A
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS 1417
Query: 815 LEEENSR 821
LE+ R
Sbjct: 1418 LEKTKQR 1424
Score = 42.7 bits (99), Expect = 0.001
Identities = 66/297 (22%), Positives = 119/297 (40%), Gaps = 71/297 (23%)
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 650
L + +KP S + E A + ++ KEE+A EL+ ++ L +EK L+L++
Sbjct: 836 LFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQV 895
Query: 651 STR-----EAQEQA---------YLVHIEHLKSEVEEQKEQ------RMRSLSSTSSGSK 690
+ +A+E+ ++ L +EE++E + R+L S K
Sbjct: 896 QSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK 955
Query: 691 ----------DKPGKECADAASPALSLAELRTTCSEN--------------------ELA 720
K KE + +L+E T EN +L
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 721 AE---FTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYE 777
E I+ KL+ + +L +LE+ K + + DLK + +++ E
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIM-DLE 1074
Query: 778 KAKKKHQNKLKKLE---SQMMAMVE-------RHETQVRMLKQRIALLEEENSRPHT 824
K++ + KLKK E SQ+ A ++ + + +++ L+ RI LEEE HT
Sbjct: 1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 84.0 bits (206), Expect = 5e-16
Identities = 157/844 (18%), Positives = 339/844 (40%), Gaps = 91/844 (10%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLR------Y 78
+A++K + + + L +TE +R LE+K+ LM+E D+Q +
Sbjct: 853 MANMKEEFEKTKEELAKTEAKRKELEEKMVT-------LMQEKNDLQLQVQAEADALADA 905
Query: 79 EERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSV 138
EER +L +L KI + T R EDE E+ +EL+ + ++ ++ + +D
Sbjct: 906 EERCDQLIKTKIQLEAKIKEV---TERAEDE-EEINAELTAKKRKLEDECSELKKD---- 957
Query: 139 SIPENQSTMVTADMDNCSDLN--SELQRVLTGLENVVCGRKKSSCSLSVA------EVDR 190
I + + T+ + + + N L + GL+ + K +L A ++
Sbjct: 958 -IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQM 1016
Query: 191 HIEQLTTASEHCDLAIKTVEEIEGVLGRD--LYPNLAEERSRWEKELAGLRE-------E 241
+++ T ++ + V+++EG L ++ L +L + + E +L +E +
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEND 1076
Query: 242 NESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTST 301
+ L L KE E++ + + + +L+++++ELQ R++ ++ +
Sbjct: 1077 KQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 302 NRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS-----DRPVLGSEISSIGV 356
+ + + EL S + + +++++K R + L E ++ +
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAAL 1196
Query: 357 SSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDL 416
A+ +A + ++Q + Q L S + + +I + E ++ + +
Sbjct: 1197 RKKHADSVAELGEQIDSLQRVKQKLEKEKSEL-KMEINDLASNMETVSKAKANFEKMCRT 1255
Query: 417 LTITLEECKSNAERMSMLVGKYESNATALRL-ALQYSEQCIEAYELLLALAESEQSLILG 475
L L E K+ E L+ + + L + ++S Q E ++ L+ +Q+
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFT-- 1313
Query: 476 QFRAAGVGSSPGDQSGDENITQMLKRA-HDC-----RKTAENAAKALLMKLDGSCGGAFA 529
Q + + L+ A HDC + E AKA L + +
Sbjct: 1314 QQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQR-------GMS 1366
Query: 530 VAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKD---YIQQLKNDRAAVKLT 586
A V W + T E K+ QRL+D +++ + + A+++ T
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEEL-----EEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 587 MLELESIHIDPLSYDV-KPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKA 645
L++ ++ L DV + LD + + L K++ E +A+L +KE ++
Sbjct: 1422 KQRLQN-EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRS 1480
Query: 646 LELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSK-----DKPGKECADA 700
L +L + + L H+E LK E + +++ + G K +K K+
Sbjct: 1481 LSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHE 1540
Query: 701 ASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALER-LTKSSEIRHQQSA 759
S EL+T+ E E + E + +++ + ++ S ++R + + E Q
Sbjct: 1541 KS------ELQTSLEEAEASLEHEEG--KILRIQLELNQVKSEIDRKIAEKDEELDQLKR 1592
Query: 760 EFVNDLKRANSNLVAAYE------KAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIA 813
+ ++ S L A + KKK + L ++E Q+ + +R L+
Sbjct: 1593 NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQG 1652
Query: 814 LLEE 817
+L++
Sbjct: 1653 ILKD 1656
Score = 57.4 bits (137), Expect = 5e-08
Identities = 113/608 (18%), Positives = 228/608 (37%), Gaps = 51/608 (8%)
Query: 232 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQS---VQ 288
EKE+A ++EE E +EEL +T+A + E+ L + +LQ ++Q+
Sbjct: 850 EKEMANMKEEFE-------KTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADAL 902
Query: 289 ATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLG 348
A +L T + E++ + + A++ + + + D L
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 349 SEISSIGVSSSVAEHLAHSL-QDCSNIQEIFQTLYSHGSAISES---KIREFEVETERLN 404
++ + E+ +L ++ + + E L A+ E+ + + ++E +++N
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVN 1022
Query: 405 SRIE---HLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYEL 461
+ + L+ Q D L +LE+ K + K E + + + +E +
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNE 1082
Query: 462 LLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLD 521
L E E S + G+ + + E ++ + + + AKA + D
Sbjct: 1083 KLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142
Query: 522 GSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRA 581
S L S + A+S E K+ E + + L+
Sbjct: 1143 LS---------------RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTL 1187
Query: 582 AVKLTMLELESIHIDPLSYDVKPRGDS-----QRLDLENAVLMQELMAMKEEMAELKAQL 636
+ T L H D ++ ++ + DS Q+L+ E + L E+ + M +
Sbjct: 1188 QHEATAAALRKKHADSVA-ELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAK 1246
Query: 637 YLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKE 696
EK + LE +LS + +E+ + L +E+ QK R+ + S S D+
Sbjct: 1247 ANFEKMCRTLEDQLSEIKTKEEEQ----QRLINELSAQK-ARLHTESGEFSRQLDE---- 1297
Query: 697 CADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQ 756
DA LS + T EL + + + L +Q + L + E +
Sbjct: 1298 -KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQE 1356
Query: 757 QSAEFVNDLKRANSNLV---AAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIA 813
AE + +ANS + YE + +L++ + ++ ++ E V + + A
Sbjct: 1357 AKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCA 1416
Query: 814 LLEEENSR 821
LE+ R
Sbjct: 1417 SLEKTKQR 1424
Score = 53.9 bits (128), Expect = 6e-07
Identities = 124/688 (18%), Positives = 266/688 (38%), Gaps = 75/688 (10%)
Query: 3 SGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSH 62
SG + ++ A +S+L S + I EL ++L++ + + L L A+
Sbjct: 1288 SGEFSRQLDEKDAMVSQL-SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSAR-HDCD 1345
Query: 63 LMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQH 122
L+RE + ++ + +++ +S +A+ K + I+ +E E + +L+Q
Sbjct: 1346 LLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYET---DAIQRTEELEEAKKKLAQRLQ 1402
Query: 123 EVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCS 182
+ E V A C+ L QR+ +E+++ ++S+ +
Sbjct: 1403 DAEEH--------------------VEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAA 1442
Query: 183 -LSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKEL---AGL 238
+++ + R+ +++ + + E R L L + ++ +E+ L L
Sbjct: 1443 CIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETL 1502
Query: 239 REENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRL 298
+ EN++L + E++ ++ + + + +L ELQT L+ +A+ G++
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI 1562
Query: 299 TSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSS 358
+N E+ + D E +L + S + L +EI S +
Sbjct: 1563 LRIQLELNQVKSEIDRKIAEKD------EELDQLKRNHLRVVESMQSTLDAEIRSRNDAL 1616
Query: 359 SVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL----KSQN 414
+ + + L + + +H + + +R L HL + Q+
Sbjct: 1617 RIKKKMEGDLNE-------MEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQD 1669
Query: 415 DLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLIL 474
DL +E + ER + L+ ++ LR +L+ +E+ + E L L SE+ +L
Sbjct: 1670 DL-----KEQLAMVERRANLM---QAEVEELRASLERTERGRKMAEQEL-LDASERVQLL 1720
Query: 475 GQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCS 534
+ + + + + +I+Q+ D + A NA + + + A
Sbjct: 1721 HTQNTSLINTK---KKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMA------- 1770
Query: 535 VQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQL-----KNDRAAVKLTMLE 589
E L TS + E T +D Q D +QL K ++ + E
Sbjct: 1771 ----EELKKEQDTSAHLERMKK-NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1825
Query: 590 LESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELK 649
LES ++V+ ++ + L + ++ + L+ + L+ + KA + +
Sbjct: 1826 LESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ 1885
Query: 650 LSTREAQEQAYLVHIEHLKSEVEEQKEQ 677
E Q L L+ E+EE KE+
Sbjct: 1886 AEEAEEQSNVNLAKFRKLQHELEEAKER 1913
Score = 43.1 bits (100), Expect = 0.001
Identities = 60/255 (23%), Positives = 111/255 (43%), Gaps = 34/255 (13%)
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 650
L + +KP S + E A + +E KEE+A EL+ ++ L +EK L+L++
Sbjct: 836 LYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895
Query: 651 STR-----EAQEQA-----YLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADA 700
+A+E+ + +E EV E+ E +++ + K K EC++
Sbjct: 896 QAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSEL 954
Query: 701 ASPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSA 759
+ +L T ++ E T N ++ + A + E ++ L + K+ + HQQ+
Sbjct: 955 KK---DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT- 1010
Query: 760 EFVNDLKRANSNLVAAYEKAKKKHQNKLKKLE---SQMMAMVERHETQVRMLKQRIALLE 816
++DL + + V KAK K + ++ LE Q + E R L+ + L +
Sbjct: 1011 --LDDL-QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQ 1067
Query: 817 E-----ENSRPHTNE 826
E EN + NE
Sbjct: 1068 ESTMDTENDKQQLNE 1082
Score = 39.7 bits (91), Expect = 0.012
Identities = 57/289 (19%), Positives = 115/289 (39%), Gaps = 30/289 (10%)
Query: 10 GNDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHED 69
G D E + ++ ++ EL L++TER R + E++L D
Sbjct: 1667 GQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELL--------------D 1712
Query: 70 VQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSR 129
ER L + + T L + +L I ++QG ED E R+ +++ + + +
Sbjct: 1713 ASERVQLLHTQN-TSLINTKKKLETDISQIQG---EMEDIVQEARNAEEKAKKAITDAAM 1768
Query: 130 SMD----QDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVC---GRKKSSCS 182
+ + TS + + M D L+ Q L G + + R + S
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELES 1828
Query: 183 LSVAEVDRHIEQLTTASEH----CDLAIKTVEEIEGVLG-RDLYPNLAEERSRWEKELAG 237
+E ++E + +H +L +T E+ + +L +DL L + ++++
Sbjct: 1829 EVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEE 1888
Query: 238 LREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQS 286
E++ A + EL K + + ++LR + RE+ T++ S
Sbjct: 1889 AEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVIS 1937
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 83.6 bits (205), Expect = 7e-16
Identities = 172/869 (19%), Positives = 347/869 (39%), Gaps = 119/869 (13%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+A++K + + L ++E +R LE+KL E++ L + + + L EER +
Sbjct: 850 MATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ-AESENLLDAEERCDQ 908
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
L +L KI + T R EDE E+ +EL+ + ++ ++ + +D I + +
Sbjct: 909 LIKAKFQLEAKIKEV---TERAEDE-EEINAELTAKKRKLEDECSELKKD-----IDDLE 959
Query: 145 STMVTADMDNCSDLN--SELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHC 202
T+ + + + N L L+GL+ + + +L A + ++ L +
Sbjct: 960 LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH-QQALDDLQAEEDKV 1018
Query: 203 DLAIKT-------VEEIEGVLGRDLYPNLAEERSRWEKE---------LAGLREENESLT 246
+ KT VE++E L ++ + ER++ + E + L + + L
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Query: 247 AMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPIN 306
L K+ E + ++ + + + +++++ELQ R++ ++ + T + +
Sbjct: 1079 ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRS 1138
Query: 307 PSTGELSTSSSSNDIPIAKIAERVKLSKTRSES-----SSSDRPVLGSEISSIGVSSSVA 361
EL S + + +++L+K R + L E + A
Sbjct: 1139 DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHA 1198
Query: 362 EHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL-KSQNDLLTIT 420
+ +A + N+Q + Q L E + EF++E + L+S +E + KS+ +L I
Sbjct: 1199 DSVAELGEQIDNLQRVKQKL--------EKEKSEFKLEIDDLSSSMESVSKSKANLEKI- 1249
Query: 421 LEECKSNAERMSMLVGKYESNATAL-RLALQYSEQCIEAYELLLALAESEQSLILGQFRA 479
C++ +++S GK E +L L Q S EA EL L E E I+ Q
Sbjct: 1250 ---CRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKES--IVSQL-- 1302
Query: 480 AGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCG-------------- 525
S Q+ + T+ LKR + A+NA L C
Sbjct: 1303 -----SRSKQAFTQQ-TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1356
Query: 526 ---GAFAVAGCSVQPW-------------------ESLSSNSHTSTTSSTASSCDTEFTK 563
A + A V W + L+ S A + +
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLE 1416
Query: 564 EDEQRLKDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAV---- 617
+ +QRL+ ++ L D RA L+ + + D + + K + + + +LE ++
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESR 1476
Query: 618 -LMQELMAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVH-IEHLKSEVEE 673
L EL +K E QL +++E K LE +++ T + E +H +E + ++E
Sbjct: 1477 SLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIEL 1536
Query: 674 QKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKL 733
+K +L + + + K L L ++++ + ++A + + ++
Sbjct: 1537 EKADIQLALEEAEAALEHEEAK----ILRIQLELTQVKSEI-DRKIAEKDEEIEQLKRNY 1591
Query: 734 KARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKK--KH----QNKL 787
+ V+ + SAL+ +S + + DL L A +A + KH Q +L
Sbjct: 1592 QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL 1651
Query: 788 KKLESQMMAMVERHETQVRMLKQRIALLE 816
K + + + E LK+++A++E
Sbjct: 1652 KDTQLHLDDALRGQED----LKEQLAIVE 1676
Score = 46.6 bits (109), Expect = 9e-05
Identities = 63/293 (21%), Positives = 126/293 (43%), Gaps = 29/293 (9%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQC--EQSHLMREHEDVQE-RTTLRYEER 81
+A L I E K + + E+ R +E + A Q E++ EHE+ + R L +
Sbjct: 1510 IADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQV 1569
Query: 82 ITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIP 141
+E+ IAE +++I++L+ R + +S++E + M+ D + I
Sbjct: 1570 KSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ 1629
Query: 142 ENQSTMVTAD-MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAE-----VDRHIEQL 195
+ + A+ + + + +L+ L++ + G++ L++ E + +E+L
Sbjct: 1630 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEEL 1689
Query: 196 TTASEHCDLAIKTVEEI-----EGV-LGRDLYPNLAEERSRWEKELAGLREENESLTAML 249
E + A K E+ E V L +L + + E +L L+ E E +
Sbjct: 1690 RATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDA 1749
Query: 250 CSKEEELNR--TKATMNA--IREERD----------RLRRRVRELQTRLQSVQ 288
+ EE+ + T A M A +++E+D L + V++LQ RL +
Sbjct: 1750 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Score = 46.2 bits (108), Expect = 1e-04
Identities = 51/215 (23%), Positives = 100/215 (46%), Gaps = 26/215 (12%)
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 650
L + +KP S + E A + +E K+E+A EL+ +L L +EK L+L++
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV 892
Query: 651 STR-----EAQEQAYLV-----HIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADA 700
+A+E+ + +E EV E+ E +++ + K K EC++
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSEL 951
Query: 701 ASPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSA 759
+ +L T ++ E T N ++ + + + E ++ L R K+ + HQQ+
Sbjct: 952 KK---DIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQA- 1007
Query: 760 EFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQM 794
++DL +A + V + K K K + +++ LES +
Sbjct: 1008 --LDDL-QAEEDKVNSLNKTKSKLEQQVEDLESSL 1039
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 82.4 bits (202), Expect = 2e-15
Identities = 149/823 (18%), Positives = 321/823 (39%), Gaps = 120/823 (14%)
Query: 16 ELSELHSAALASLKGDIVELNKRLQQTERERDLL-------EKKLAKAQCEQSHLMREHE 68
EL + S+ ++ L D L ++LQ E++ L E ++A+ E+ L++E E
Sbjct: 2014 ELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESE 2073
Query: 69 DVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDS 128
+Q R + E++ ++ A L +K E LS +Q EV++
Sbjct: 2074 SLQARLSESDYEKLNVSKALEAALVEK---------------GEFALRLSSTQEEVHQLR 2118
Query: 129 RSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEV 188
R +++ + + E + + + N L+ + LE L ++E
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLER----------ELQMSEE 2168
Query: 189 DRHIEQLTTASEHCDL-AIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTA 247
++ + L + ++ +KT E +A +E +L LR E E+LT
Sbjct: 2169 NQELVILDAENSKAEVETLKTQIE-----------EMARSLKVFELDLVTLRSEKENLTK 2217
Query: 248 MLCSKE---EELNRTKATMNAIREERDRLRRRVRE-LQTRLQSVQATGPSSPGRLTSTNR 303
+ K+ EL++ ++ ++ EE+++ +++E +T ++ +Q +L N
Sbjct: 2218 QIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQ-------NQLKELNE 2270
Query: 304 PINPSTGE---LSTSSSSNDIPIAKIAE-RVKLSKTRSESSSSDRPVLGSEISSIGVSSS 359
+ G+ + + S D PI + + R + K R+ + ++ L + + S
Sbjct: 2271 AVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQL-CVLQQLKESEH 2329
Query: 360 VAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTI 419
A+ L +++ EI +T H + +E+ + E E L ++IE + L +
Sbjct: 2330 HADLLKGRVENLERELEIARTNQEHAALEAENS----KGEVETLKAKIEGMTQSLRGLEL 2385
Query: 420 TLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRA 479
+ +S E ++ + K + + L + E ++ E EQ + Q +
Sbjct: 2386 DVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ---------EKEQEKV--QMKE 2434
Query: 480 AGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWE 539
+ Q+ + + + + H+ + A KA L +Q +
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHN----DQEACKAKEQNLSSQVECLELEKAQLLQGLD 2490
Query: 540 SLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKN---DRAAVKLTMLELESIHID 596
+N +S + E K+ ++ + I +LKN D+ + + ++E H
Sbjct: 2491 EAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH-- 2548
Query: 597 PLSYDVKPRGDSQRLDLENAV--LMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTRE 654
Q L+L N L Q++ ++ + A L+ L +L+ K LE +L +
Sbjct: 2549 -------QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTK 2601
Query: 655 AQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTC 714
+ +++ + + ++ E + + T+ ++ G++
Sbjct: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK------------------ 2643
Query: 715 SENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVA 774
N LA E + K K +++EL L KS + H+ E ++ +
Sbjct: 2644 --NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQL 2701
Query: 775 AYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEE 817
+A+KKHQ L Q +E +++ ++++ EE
Sbjct: 2702 RLHEAEKKHQALLLDTNKQ-------YEVEIQTYREKLTSKEE 2737
Score = 79.7 bits (195), Expect = 1e-14
Identities = 167/864 (19%), Positives = 359/864 (41%), Gaps = 104/864 (12%)
Query: 9 YGNDSSAELSELHSAALASLKGDIVELNKRLQQTERER-------DLLEKKLAKAQCE-- 59
+ N SS L + A L+ I EL RLQ E+E L+ +L KA+ E
Sbjct: 271 FDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI 330
Query: 60 -QSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELS 118
+ ++ + D RTT +Y++ T+ ++ +L K + L E L ++
Sbjct: 331 EKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK 390
Query: 119 QSQHEVNED-SRSMDQDQT--------------SVSIPENQSTMVTADMDNCSDLNSELQ 163
+ + E E+ SR QT + +N ++ A++D + + +L+
Sbjct: 391 EKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLE 450
Query: 164 RVLTGLENVVCGRKKS--SCSLSVAEVDRHIEQL----TTASEHCDLAIKTVEEIEGVLG 217
L + +C +++ + + E+ R +E++ H + + V +E L
Sbjct: 451 NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL- 509
Query: 218 RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRV 277
N+ + ++ + ++ +N S ML +E++N+ + ++ ++L+ V
Sbjct: 510 ----KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTL-----EKLKLAV 560
Query: 278 RELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRS 337
+L+ + Q + N ++ + E S+ ++ K E +K KT
Sbjct: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK-KKEYEELKEEKTLF 619
Query: 338 ESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFE 397
S+ L +++ S ++ + H L+ C Q+I Y+ ++R E
Sbjct: 620 SCWKSENEKLLTQMES--EKENLQSKINH-LETCLKTQQIKSHEYN-------ERVRTLE 669
Query: 398 VETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIE 457
++ E L+ I +L + D ++ +E ++++ + + ++ + + + C++
Sbjct: 670 MDRENLSVEIRNLHNVLDSKSVEVE-----TQKLAYMELQQKAEFSDQKHQKEIENMCLK 724
Query: 458 AYELLLALAESEQSLILGQFRAAGVGSSPGDQSGD-ENITQMLKRAHDCRKTAENAAKAL 516
+L + + E L L D + E++ +LK T E+ ++L
Sbjct: 725 TSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSL 784
Query: 517 L-MKLDGSCGGAFA--VAGCSVQPWE----SLSSNSHTSTTSSTASSCDT-EFTKEDEQR 568
L + +FA + P E L ++ ++ + D+ EF+ E +++
Sbjct: 785 LAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ 844
Query: 569 LKDYIQ----QLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMA 624
+ +Q +L + ++ +++ E +H ++ SQR+ + L ++ A
Sbjct: 845 MNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA------ETSQRI----SKLQEDTSA 894
Query: 625 MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLK--SEVEEQKEQRMRSL 682
+ +AE + L EKE + L K+ T +A+ I+ LK + + E + ++ L
Sbjct: 895 HQNVVAETLSALENKEKELQLLNDKVETEQAE-------IQELKKSNHLLEDSLKELQLL 947
Query: 683 SSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREK-KLKARVQELV 741
S T S K KE + S L+ E+ EN E ++ +EK L + +
Sbjct: 948 SETLSLEK----KEMSSIIS--LNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
Query: 742 SALERLTKS-SEIRHQQSAEFVNDLKR------ANSNLVAAYEKAKKKHQNKLKKLESQM 794
+ ++ KS SE+ Q E + L+R A +L Y+ A++K+ +KL+ L ++
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN-SKLECLLNEC 1060
Query: 795 MAMVERHETQVRMLKQRIALLEEE 818
++ E + ++ LK+ A +E
Sbjct: 1061 TSLCENRKNELEQLKEAFAKEHQE 1084
Score = 70.5 bits (171), Expect = 6e-12
Identities = 145/847 (17%), Positives = 338/847 (39%), Gaps = 91/847 (10%)
Query: 33 VELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQE-RTTLRYEERITELHSVIAE 91
+EL K + + ++E L +KL C+ L++ E + + L + +
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
Query: 92 LNKKIDRLQGTTIREEDEYSELRSELSQSQHE----------VNEDSRSMDQD----QTS 137
+ K D + + E+E S +RSE + +HE V + +++D Q
Sbjct: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKV 1945
Query: 138 VSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTT 197
+ E + ++VT++ + + + T L+ + K+ + E++ H +
Sbjct: 1946 IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT-----QELESHQSECLH 2000
Query: 198 ASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELN 257
+ + +K E+ L D+ L ++++ +++L L +++++L+ C E ++
Sbjct: 2001 CIQVAEAEVKEKTELLQTLSSDV-SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 258 RTKATMNAIREERDRLRRRVRE-------LQTRLQSVQATGPSSPGRLTSTNRPINP--- 307
+ + +E + L+ R+ E + L++ RL+ST ++
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 308 STGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHS 367
+L +++ IAE++K + ++S L E+ + +
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELV------ 2173
Query: 368 LQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSN 427
+ D N + +TL + ++ S ++ FE++ L S E+L Q ++E +
Sbjct: 2174 ILDAENSKAEVETLKTQIEEMARS-LKVFELDLVTLRSEKENLTKQ-------IQEKQGQ 2225
Query: 428 AERMSMLVGKYESNATALRLA-LQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSP 486
+ L+ ++S A +Q E+ A E+L Q L + AA G
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML-----QNQLKELNEAVAALCGDQE 2280
Query: 487 GDQSGDENITQMLKRAHDCRKTAENAAKAL----------LMKLDGSCGGAFAVAGCSVQ 536
++ ++++ ++ H R + E L L +L S A + G
Sbjct: 2281 IMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKG---- 2336
Query: 537 PWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHID 596
E+L + T+ ++ + E +K + + LK I+ + ++L ++ + S +
Sbjct: 2337 RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396
Query: 597 PLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQ----LYLLEKEKKALELKLST 652
+ K + L++ N+ L ++E ++K + + +L+ + K L +++
Sbjct: 2397 LTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA 2456
Query: 653 REAQEQAYLVHIEHLKSEV---EEQKEQRMRSLSSTSSG------------SKDKPGKEC 697
++A ++L S+V E +K Q ++ L + + + GK+
Sbjct: 2457 LHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQK 2516
Query: 698 ADAASPALSLAELRTTCSENELAAEFTNAIRRE----KKLKARVQELVSALERLTKSSEI 753
+ +S L+ + E + + E K+ ++ L LE+ + +
Sbjct: 2517 LEKKDEEIS--RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQS 2574
Query: 754 RHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIA 813
++ + + L+ + NL E K + ++K+ ++M A + ++ + Q+ A
Sbjct: 2575 KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV-NKMTAKETELQREMHEMAQKTA 2633
Query: 814 LLEEENS 820
L+EE S
Sbjct: 2634 ELQEELS 2640
Score = 63.5 bits (153), Expect = 7e-10
Identities = 151/741 (20%), Positives = 278/741 (37%), Gaps = 134/741 (18%)
Query: 27 SLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELH 86
SLK + L + LQ +E ++L+ ++ E L + E++ R+ +E + L
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA-RSLKVFELDLVTLR 2209
Query: 87 SVIAELNKKIDRLQGT------------TIREEDEYSELRS--------ELSQSQ-HEVN 125
S L K+I QG ++ EE E +E++ E+ Q+Q E+N
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELN 2269
Query: 126 EDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSV 185
E ++ DQ + E + ++ L + ++++ LE KK C L
Sbjct: 2270 EAVAALCGDQEIMKATEQS---LDPPIEEEHQLRNSIEKLRARLE---ADEKKQLCVL-- 2321
Query: 186 AEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREEN--- 242
+QL + H DL VE +E L E +R +E A L EN
Sbjct: 2322 -------QQLKESEHHADLLKGRVENLEREL----------EIARTNQEHAALEAENSKG 2364
Query: 243 --ESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTS 300
E+L A + + L + + IR E++ L +++ Q R+ ++ S L
Sbjct: 2365 EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE 2424
Query: 301 TNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSV 360
+ + ST+ + ++ ERV E+ + L S++ + + +
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKA- 2483
Query: 361 AEHLAHSLQDCSN------------IQEIF---QTLYSHGSAISE------------SKI 393
L L + N IQE+ Q L IS SK+
Sbjct: 2484 --QLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKL 2541
Query: 394 REFEVE--------------TERLNSRIEHLKSQNDLLTITLEECKSNAERMS-----ML 434
+ E E T L +I+ L+S+N L TLE +S+ + +
Sbjct: 2542 SQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTK 2601
Query: 435 VGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGS-------SPG 487
+ K ++ + +E E +E+ AE ++ L + R AG S
Sbjct: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
Query: 488 DQSGDENITQM-LKRAHDCR---------KTAENAAKALLMKLDGSCGGAFAVAGCSVQP 537
DQ + + LK++ DC K E A+ L + + + Q
Sbjct: 2662 DQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQY 2721
Query: 538 WESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDP 597
+ + T+ S K + LK ++L N A + EL+ +D
Sbjct: 2722 EVEIQTYREKLTSKEECLSSQ----KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE--KEKKALELKLSTREA 655
L Y + + +++R + +L++ ++EE L+ +L L+ +EK+ + T+
Sbjct: 2778 LKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTK-- 2835
Query: 656 QEQAYLVHIEHLKSEVEEQKE 676
++ L +E++E KE
Sbjct: 2836 --------VDELTTEIKELKE 2848
Score = 61.6 bits (148), Expect = 3e-09
Identities = 149/811 (18%), Positives = 310/811 (38%), Gaps = 132/811 (16%)
Query: 31 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIA 90
DI L R+++T E L + + L+ E +++ + L+ + +T++ + I
Sbjct: 1768 DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI- 1826
Query: 91 ELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTA 150
+++++ G +E + SE S E+ + + + + + + ++S+
Sbjct: 1827 ----ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDI 1882
Query: 151 DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE 210
DN + +N + +EN + + S+ EH L ++
Sbjct: 1883 G-DNVAKVNDSWKERFLDVENELSRIRSEKASI----------------EHEALYLEADL 1925
Query: 211 EIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREER 270
E+ + E L ++NE+ ++ EEEL+ + N +R E
Sbjct: 1926 EVV------------------QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
Query: 271 DRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSS----NDIPIAKI 326
D + ++ L + + T EL + S + A++
Sbjct: 1968 DTMSKKTTALD------------------QLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
Query: 327 AERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGS 386
E+ +L +T L S++S + L+D +++QE Q+L
Sbjct: 2010 KEKTELLQT-----------LSSDVSEL-------------LKDKTHLQEKLQSLEKDSQ 2045
Query: 387 AISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALR 446
A+S +K E E + +LN E L +++ L L E S+ E++++ + AL
Sbjct: 2046 ALSLTKC-ELENQIAQLNKEKELLVKESESLQARLSE--SDYEKLNV--------SKALE 2094
Query: 447 LALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGS----SPGDQSGDENITQMLK-- 500
AL +E E L L+ +++ + Q R G+ D+ +I + LK
Sbjct: 2095 AAL------VEKGEFALRLSSTQEE--VHQLR-RGIEKLRVRIEADEKKQLHIAEKLKER 2145
Query: 501 -RAHDCRK-TAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCD 558
R +D K EN + L M + A S E+L + S D
Sbjct: 2146 ERENDSLKDKVENLERELQMSEENQ-ELVILDAENSKAEVETLKTQIEEMARSLKVFELD 2204
Query: 559 TEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVL 618
+ +++ L IQ+ + + + + +S+ + K + + Q + E+
Sbjct: 2205 LVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSL------LEEKEQAEIQ-IKEESKTA 2257
Query: 619 MQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQR 678
++ L +E+ E A L ++ KA E L +E IE L++ +E ++++
Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317
Query: 679 MRSLSSTSSGSKDKPGKECADAASPALSLAELR---TTCSENELAAEFTNAIRREKKLKA 735
+ L K + AD + E ++ A E N+ + LKA
Sbjct: 2318 LCVLQQL------KESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA 2371
Query: 736 RVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMM 795
+++ + +L L + N+L++ ++ E +N L++ E + +
Sbjct: 2372 KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER-ISELEIINSSFENILQEKEQEKV 2430
Query: 796 AMVERHETQVRMLKQRIALLEEENSRPHTNE 826
M E+ T + ML+ ++ L E + H ++
Sbjct: 2431 QMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
Score = 61.2 bits (147), Expect = 4e-09
Identities = 142/696 (20%), Positives = 277/696 (39%), Gaps = 87/696 (12%)
Query: 169 LENVVCGRKKSSCSLSVAEVDRHIEQLTTAS-EHCDLAIKTVEEIEGVLG---------- 217
LE +V KK + LS E+L S +H +L ++ VE EG+
Sbjct: 1828 LEKIVGELKKENSDLS--------EKLEYFSCDHQEL-LQRVETSEGLNSDLEMHADKSS 1878
Query: 218 -RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRR 276
D+ N+A+ W++ + E + + S E E +A + ++ E+ L +
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKD 1938
Query: 277 VRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTR 336
Q + ++ L+ N GEL T S + +++E++K
Sbjct: 1939 NENKQKVIVCLEE-------ELSVVTSERNQLRGELDTMSKKTTA-LDQLSEKMKEKTQE 1990
Query: 337 SESSSSDR----PVLGSEISS-IGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISES 391
ES S+ V +E+ + +++ ++ L+D +++QE Q+L A+S +
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
Query: 392 KIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQY 451
K E E + +LN E L +++ L L E S+ E++++ + AL AL
Sbjct: 2051 KC-ELENQIAQLNKEKELLVKESESLQARLSE--SDYEKLNV--------SKALEAAL-- 2097
Query: 452 SEQCIEAYELLLALAESEQSLILGQFRAAGVGSS----PGDQSGDENITQMLK---RAHD 504
+E E L L+ +++ + Q R G+ D+ +I + LK R +D
Sbjct: 2098 ----VEKGEFALRLSSTQEEV--HQLRR-GIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
Query: 505 CRKT-AENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTK 563
K EN + L M + A S E+L + S D +
Sbjct: 2151 SLKDKVENLERELQMSEENQ-ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR 2209
Query: 564 EDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELM 623
+++ L IQ+ + + + + +S+ + K + + Q + E+ ++ L
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSL------LEEKEQAEIQ-IKEESKTAVEMLQ 2262
Query: 624 AMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLS 683
+E+ E A L ++ KA E L +E IE L++ +E +++++ L
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
Query: 684 STSSGSKDKPGKECADAASPALSLAELR---TTCSENELAAEFTNAIRREKKLKARVQEL 740
K + AD + E ++ A E N+ + LKA+++ +
Sbjct: 2323 QL------KESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGM 2376
Query: 741 VSALERLTKSSEIRHQQSAEFVNDLKRANSNLV------AAYEKA-KKKHQNKLKKLESQ 793
+L L + N+L++ + +++E ++K Q K++ E
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKS 2436
Query: 794 MMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 829
AM E +TQ++ L +R+A L + E +L
Sbjct: 2437 STAM-EMLQTQLKELNERVAALHNDQEACKAKEQNL 2471
Score = 51.6 bits (122), Expect = 3e-06
Identities = 153/811 (18%), Positives = 318/811 (39%), Gaps = 77/811 (9%)
Query: 28 LKGDIVELNK-RLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTL--RYEERITE 84
L D VE + +Q+ ++ LLE L + Q L E +++ +L R E +T+
Sbjct: 915 LLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ 974
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRS-----MDQDQTSVS 139
+ + E+N +++ + I++ + ++ E +S E+++ + + + + + +
Sbjct: 975 ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGN 1034
Query: 140 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTT-- 197
E+ S A + NS+L+ +L ++ RK L A H E LT
Sbjct: 1035 AYEDLSQKYKAAQEK----NSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090
Query: 198 -ASEHCDLAIKTVEEIEGVLGRDLYPN-----------------LAEERSRWEKELAGLR 239
A E + +E ++ L ++ N L EE+++ +KE+ L
Sbjct: 1091 FAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1150
Query: 240 EENESLTAMLCSKEEELN-RTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRL 298
+ENE L ++ +K E N ++ N+++E + + Q L+ + + S +L
Sbjct: 1151 QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL 1210
Query: 299 TSTNRPINPSTGELSTSSSSNDI---PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIG 355
+ +L S + + I ++ S + S + EI +
Sbjct: 1211 VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE 1270
Query: 356 VSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISE----SKIREFEVETERLNSRIEHLK 411
S L+ S D +++Q QT + + + + + ++E+ TE +SR E +
Sbjct: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT 1330
Query: 412 SQNDL---LTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQC---------IEAY 459
+ + + L E K + +L G+ + Q +EQ +Y
Sbjct: 1331 ATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSY 1390
Query: 460 ELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAEN-AAKALLM 518
E L L++ E + + + + + + QM + + + ++ A+ L++
Sbjct: 1391 E-HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL 1449
Query: 519 KLDGSCGGAFAVAGCSVQPWESL---SSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQ 575
+ V + E L S+S +SS +S D+ F + ++ D +
Sbjct: 1450 STNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGD-MSL 1508
Query: 576 LKNDRAAVKLTMLELESIHIDPLSYDVKPRGDS--------QRLDLENAVLMQELMAMKE 627
L N AV ++ + L + R ++ + L+ V Q L ++E
Sbjct: 1509 LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEE 1568
Query: 628 EMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS 687
+M ++Q + KE + LE LS+ E QE ++ L+ + + EQ + L+S +
Sbjct: 1569 KM---ESQGIMKNKEIQELEQLLSS-ERQE------LDCLRKQYLSENEQWQQKLTSVTL 1618
Query: 688 GSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERL 747
+ K E +L L R +L++ I E ++ R + + E
Sbjct: 1619 EMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHT 1678
Query: 748 TKSSEIRHQQSAEFVNDLKRANSNLVAAYEK 778
++++E + + D K A +L EK
Sbjct: 1679 SETTERTPKHDVHQICD-KDAQQDLNLDIEK 1708
Score = 50.1 bits (118), Expect = 9e-06
Identities = 149/797 (18%), Positives = 305/797 (38%), Gaps = 108/797 (13%)
Query: 66 EHEDVQERTTLRYEERITELHSVIAELNKKIDR-LQGTTIREEDEYSELRSELSQSQHEV 124
++ED++E+ EER V A KK + L T+ D ++H+
Sbjct: 163 KYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDI----------ARHQA 212
Query: 125 NEDSRSMDQDQTSVSIPEN-QSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSL 183
+ S Q++T + N Q T + D + S + E Q V + G++ ++ S
Sbjct: 213 SSSVFSWQQEKTPSHLSSNSQRTPIRRDF-SASYFSGE-QEVTPSRSTLQIGKRDANSSF 270
Query: 184 SVAEVDRHI-EQLTTASEHCDLAIKTVE-EIEGVLGRDLYPNLAEERSRWEKELAGLREE 241
H+ +QL ++ I +E ++G EKE+ G +
Sbjct: 271 FDNSSSPHLLDQLKAQNQELRNKINELELRLQG----------------HEKEMKGQVNK 314
Query: 242 NESLTAMLCSKEEELNRTKATMNAIREE------------------RDRLRRRVRELQTR 283
+ L L + EL + +N R+E +L++ +L +
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374
Query: 284 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 343
Q+ ++ S ++ + S + D ++ R+ ++++ +
Sbjct: 375 RQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN- 433
Query: 344 RPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERL 403
VL +E+ + +SV + L + N++E Q L A S+I+E E L
Sbjct: 434 --VLQAELDKL---TSVKQQLEN------NLEEFKQKLCRAEQAFQASQIKENE-----L 477
Query: 404 NSRIEHLKSQNDLLTITLEE-----CKSNAERMSMLVGKYESNATALRLALQYSEQCIEA 458
+E +K +N+LL E+ C AE ++ +S A + + + Q
Sbjct: 478 RRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Query: 459 YELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQM---LKRAHDCRKTAENAAKA 515
+L + + E SL L + + A + + + +++ +D E +KA
Sbjct: 538 RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
Query: 516 LLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASS---CDTEFTKEDEQRLKDY 572
LL L+ + +E L + + + E KE+ Q ++
Sbjct: 598 LLSALE-----------LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 573 I------QQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMK 626
+ QQ+K+ ++ LE++ ++ ++ DS+ +++E L + K
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 627 EEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTS 686
E ++ K Q KE + + LK S Q + ++ L +E+ + K++ + L +
Sbjct: 707 AEFSDQKHQ-----KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD-KDRCYQDLHAEY 760
Query: 687 SGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALER 746
+D + A + L + + F N I + + + E ++
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 747 LTKSSEIRHQQ--SAEF-VNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHET 803
K+S I + S EF + K+ NS+L +K ++ ++E +M + H++
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDL----QKQCEELVQIKGEIEENLMKAEQMHQS 876
Query: 804 QVRMLKQRIALLEEENS 820
V QRI+ L+E+ S
Sbjct: 877 FVAETSQRISKLQEDTS 893
Score = 47.8 bits (112), Expect = 4e-05
Identities = 124/625 (19%), Positives = 230/625 (36%), Gaps = 96/625 (15%)
Query: 232 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATG 291
E +L L++E + L S E L + K + + E L+R + L +S++ T
Sbjct: 24 EGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTK 83
Query: 292 PSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI 351
L +N G+L++ I K+ + +K K+ E
Sbjct: 84 QKISHELQVKESQVNFQEGQLNSGKKQ----IEKLEQELKRCKSELER------------ 127
Query: 352 SSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFE-------VETERLN 404
S A+ SL C+ Q+IF T + S SK + + E +RL
Sbjct: 128 -----SQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
Query: 405 SRIEHL---KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYEL 461
+ ++ L K+ L T+ + S V ++ T L+ S++ +
Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS-SNSQRTPIRRDF 241
Query: 462 LLALAESEQSLILG----QFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALL 517
+ EQ + Q SS D S ++ LK + + N + L
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL 301
Query: 518 MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTT-----SSTASSCDTEFTKEDEQRLKDY 572
+ G V ++ L + + C E + Q
Sbjct: 302 QGHEKEMKG-------QVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ----- 349
Query: 573 IQQLKNDRAAVKLTMLELESIHIDPLSYDV---KPRGDSQRLDLENAVLMQELMAMKEEM 629
D+A+ K T LE + + L+ D+ + +S R LE + +E +EE+
Sbjct: 350 -----YDQASTKYTALEQK---LKKLTEDLSCQRQNAESARCSLEQKIKEKE-KEFQEEL 400
Query: 630 AELKAQLYLLEKEKKALELKLSTREAQE--------QAYLVHIEHLKSEVEEQKEQRMRS 681
+ + L++E ++ +L T+E Q+ QA L + +K ++E E+ +
Sbjct: 401 SRQQRSFQTLDQECIQMKARL-TQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQK 459
Query: 682 LSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELV 741
L A+ A A + E S E+ E N ++ + KAR V
Sbjct: 460 LCR-------------AEQAFQASQIKENELRRSMEEMKKE-NNLLKSHSEQKARE---V 502
Query: 742 SALERLTKSSEIRHQQSAEFVNDLKRANSN----LVAAYEKAKKKHQN-KLKKLESQMMA 796
LE K+ + QS F ++K N++ L EK ++ + L+KL+ +
Sbjct: 503 CHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVAD 562
Query: 797 MVERHETQVRMLKQRIALLEEENSR 821
+ ++ + +LK+R +E+ N +
Sbjct: 563 LEKQRDCSQDLLKKREHHIEQLNDK 587
Score = 44.7 bits (104), Expect = 4e-04
Identities = 153/800 (19%), Positives = 272/800 (34%), Gaps = 176/800 (22%)
Query: 14 SAELSELHSAALASLKGDIVELNK----RLQQTERERDLLEKKLAKAQC-EQSHLMREHE 68
S E+ LH+ + K VE K LQQ D +K + C + S L + E
Sbjct: 676 SVEIRNLHN--VLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 69 DVQERTTLRYEERIT------ELHSVIAELNKKIDRLQGTTIREEDE------------- 109
D++ + L E + +LH+ L + + + ED
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 110 ---YSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVL 166
++ + E E +E DQ + +I +N+ + +++ +NS+LQ+
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQK-- 851
Query: 167 TGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAE 226
C+ ++ EIE NL +
Sbjct: 852 ----------------------------------QCEELVQIKGEIE--------ENLMK 869
Query: 227 ERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQS 286
+ +A T+ SK +E T A N + E L + +ELQ
Sbjct: 870 AEQMHQSFVAE--------TSQRISKLQE--DTSAHQNVVAETLSALENKEKELQLLNDK 919
Query: 287 VQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPV 346
V+ T + L +N + S EL S + + +++ + L+K E + +
Sbjct: 920 VE-TEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGT 978
Query: 347 L--------GSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEV 398
L +++ I S S A ++ + S + + Y I + E
Sbjct: 979 LKEINASLNQEKMNLIQKSESFANYIDEREKSISELSD----QYKQEKLILLQRCEETGN 1034
Query: 399 ETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEA 458
E L+ + + + +N L L EC S E ++ L+ A Q
Sbjct: 1035 AYEDLSQKYKAAQEKNSKLECLLNECTSLCENR-------KNELEQLKEAFAKEHQ---- 1083
Query: 459 YELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLM 518
E L LA +E + N ML+ E +AL
Sbjct: 1084 -EFLTKLAFAE----------------------ERNQNLMLE--------LETVQQALRS 1112
Query: 519 KLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKN 578
++ + + + AG Q +L + + +E+EQ +K
Sbjct: 1113 EMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEV------NDLLQENEQLMK-------- 1158
Query: 579 DRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYL 638
V T E +++ +P+ VK R +S+R N +L + + AQL
Sbjct: 1159 ----VMKTKHECQNLESEPIRNSVKER-ESERNQC-NFKPQMDLEVKEISLDSYNAQLVQ 1212
Query: 639 LEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECA 698
LE + ELKL E +++ ++ ++ ++E Q M+ S SG KD C
Sbjct: 1213 LEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQ--SQEISGLKD-----CE 1265
Query: 699 DAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQS 758
A + S+N+ A L+ +Q ++ L L K EI +
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNA-----------HLQCSLQTTMNKLNELEKICEILQAEK 1314
Query: 759 AEFVNDLKRANSNLVAAYEK 778
E V +L + S + A K
Sbjct: 1315 YELVTELNDSRSECITATRK 1334
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/185 (22%), Positives = 84/185 (45%), Gaps = 14/185 (7%)
Query: 627 EEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTS 686
+++ EL+ QL L+KEK+ + +L + EA Q +E+ K+E K + R +
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 687 SGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALER 746
S K K S L + E + E +L + + E++LK EL + ++
Sbjct: 78 SLEKTK------QKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS-QQ 130
Query: 747 LTKSSEIR----HQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKL---KKLESQMMAMVE 799
+S+++ + F L + + YE K+K+ ++ K+LE+++ A+
Sbjct: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 800 RHETQ 804
+ +Q
Sbjct: 191 KKASQ 195
Score = 41.2 bits (95), Expect = 0.004
Identities = 163/873 (18%), Positives = 329/873 (37%), Gaps = 109/873 (12%)
Query: 21 HSAALASLKGDIVELNKRLQQTERERDLLEKKLA--KAQCEQSHLM----REHEDVQERT 74
++A L L+ + +LQ++E+E++ L+ +L + E S+L +E +++
Sbjct: 1206 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1265
Query: 75 TLRYEERITELHSVIAELN-------------KKIDRLQGTTIREEDEYSELRSELSQSQ 121
E+ I+ H + N K++ L+ + E EL +EL+ S+
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR 1325
Query: 122 HEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSC 181
E +R M ++ + N+ ++ D+ L+ EL + G E ++
Sbjct: 1326 SECITATRKMAEEVGKLL---NEVKILN---DDSGLLHGELVEDIPGGEFGEQPNEQHPV 1379
Query: 182 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREE 241
SL+ + E LT + + + ++E + L+ E
Sbjct: 1380 SLAPLDESNSYEHLTLSDKEVQMHFAELQE----------------------KFLSLQSE 1417
Query: 242 NESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTST 301
++ L C +++ + +++++ E L +R Q L G G + S
Sbjct: 1418 HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE-GLVPSL 1476
Query: 302 NRPINPSTGELST--SSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSS 359
+ P + LS+ SS + + + LS S++ + + SS
Sbjct: 1477 SSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ-----CSVDEVFCSSL 1531
Query: 360 VAEHL---------AHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL 410
E+L A +++ ++ E+++ ES+ E + L +
Sbjct: 1532 QEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1591
Query: 411 KSQNDLLTIT-LEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLL-ALAES 468
+ + D L L E + ++++ + + ES A + + +E L L L S
Sbjct: 1592 RQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLS 1651
Query: 469 EQSLILGQFRAAGVGSSPGDQSGDENITQMLKRA--HD----CRKTA--------ENAAK 514
+SL+ A G + E+ ++ +R HD C K A E +
Sbjct: 1652 SRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITE 1711
Query: 515 ALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASS------CDTEFTKEDEQR 568
+K G C G + P E + S + + S D +ED
Sbjct: 1712 TGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN 1771
Query: 569 LKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQE--LMAMK 626
L+ +++ N+ + L ++E ++ L ++K +L++ + +QE LM
Sbjct: 1772 LQLRVKETSNENLRL-LHVIEDRDRKVESLLNEMK--------ELDSKLHLQEVQLMTKI 1822
Query: 627 EEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHI---EHLKSEVEEQKEQRMRSLS 683
E EL+ + L+KE L KL Q L + E L S++E ++ R
Sbjct: 1823 EACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDI 1882
Query: 684 STSSGSKDKPGKECADAASPALSLAELRTTCSENE-------LAAEFTNAIRREKKLKAR 736
+ + KE LS E+E L T + EK + +
Sbjct: 1883 GDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENK 1942
Query: 737 VQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMA 796
+ +V E L+ + R+Q E ++ + + + L EK K+K Q +L+ +S+ +
Sbjct: 1943 QKVIVCLEEELSVVTSERNQLRGE-LDTMSKKTTALDQLSEKMKEKTQ-ELESHQSECLH 2000
Query: 797 MVERHETQVRMLKQRIALLEEENSRPHTNETSL 829
++ E +V+ + + L + S ++T L
Sbjct: 2001 CIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL 2033
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 81.6 bits (200), Expect = 3e-15
Identities = 182/875 (20%), Positives = 326/875 (37%), Gaps = 119/875 (13%)
Query: 8 KYGNDSSAELSELHSAALASLKGD--IVELNKRLQQTERERDLLEKKLAKAQCEQSHLMR 65
++ + ++ E ++ S LK + I ++ RL++ E+ R LEK + E S L
Sbjct: 1035 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1094
Query: 66 EHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDE---YSELRSELSQSQH 122
+ + Q+R + A+L +K + LQ R EDE ++L L ++Q
Sbjct: 1095 QMVEQQQRA-----------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1143
Query: 123 EVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK----- 177
+ E ++ ++ + + E Q DL EL+ + LE+ +
Sbjct: 1144 ALAEAQEDLESERVARTKAEKQRR----------DLGEELEALRGELEDTLDSTNAQQEL 1193
Query: 178 KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEER---SRWEK- 233
+S V E+ + +E+ T E A++ + + G +L L + R WEK
Sbjct: 1194 RSKREQEVTELKKTLEEETRIHE---AAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1250
Query: 234 ------ELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 287
E++ LR E SL E+ R + + ++ R E +LQ
Sbjct: 1251 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1310
Query: 288 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 347
QA + G L T LS SS + + E ++ +TR++ + R V
Sbjct: 1311 QAELENVSGALNEAES----KTIRLSKELSSTEAQLHDAQELLQ-EETRAKLALGSR-VR 1364
Query: 348 GSEISSIGVSSSVAEHLAH-------------SLQDCSNIQEIFQTLYSHGSAISESKIR 394
E + G+ + E A L + QE G R
Sbjct: 1365 AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1424
Query: 395 EFEVETERLNSR---IEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQY 451
E E T+RL + ++ L+ L L++ + E+ LV E L
Sbjct: 1425 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484
Query: 452 SEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAEN 511
+ + L A+ E E++ G+ R A S +T+ L+ + R+ E
Sbjct: 1485 EKAAV-----LRAVEERERAEAEGREREARALS----------LTRALEEEQEAREELER 1529
Query: 512 AAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE----FTKEDEQ 567
+AL +L+ V G SV E + + A + E ++ +
Sbjct: 1530 QNRALRAELEALLSSKDDV-GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKL 1588
Query: 568 RLKDYIQQLKNDRAAVKLTMLELESIHIDPLSY---DVKPRGDSQRLDLENAVLMQELMA 624
RL+ +Q LK E L+ D + D +R AV ++
Sbjct: 1589 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK--K 1646
Query: 625 MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSS 684
++ E+ ELKAQ+ + K+ +L +AQ ++ L EVEE + R S
Sbjct: 1647 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQ-------MKELWREVEETRTSREEIFSQ 1699
Query: 685 TSSGSKDKPGKEC----ADAASPALSLAELRTTCSENELAAEFTN------AIRREKK-L 733
K G E A A + +E+A E N AI EK+ L
Sbjct: 1700 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1759
Query: 734 KARVQELVSALERLTKSSEIRHQQ------SAEFVNDLKRANSNLVAAYEKAKKKHQNKL 787
+ R+ +L LE +SE+ + + E + A + A E +++ + ++
Sbjct: 1760 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1819
Query: 788 KKLESQM----MAMVERHETQVRMLKQRIALLEEE 818
++L ++ RH+ + L+ ++A EE+
Sbjct: 1820 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1854
Score = 80.9 bits (198), Expect = 5e-15
Identities = 171/839 (20%), Positives = 316/839 (37%), Gaps = 108/839 (12%)
Query: 31 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIA 90
++ EL R+ Q E ER L ++L +A+ E L E E+ + R R +E L V++
Sbjct: 899 EVGELQGRVAQLEEERARLAEQL-RAEAE---LCAEAEETRGRLAARKQE----LELVVS 950
Query: 91 ELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTA 150
EL ++ + + + + E L+ + + + + + + + Q E +
Sbjct: 951 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1010
Query: 151 DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE 210
D+ D NS+L + LE+ + + S AE + ++ L + I +E
Sbjct: 1011 DLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1065
Query: 211 -----------EIEGVLGR------DLYPNLAEERSRWEKELAGLREENESLTAMLCSKE 253
E+E + R +L + E++ R E+ A L + E L A L E
Sbjct: 1066 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1125
Query: 254 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELS 313
+E + ++RE + L E Q L+S + + + + GEL
Sbjct: 1126 DEGGARAQLLKSLREAQAAL----AEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1181
Query: 314 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 373
+ S + A++ SK E L +L++ +
Sbjct: 1182 DTLDSTN------AQQELRSKREQE----------------------VTELKKTLEEETR 1213
Query: 374 IQE--IFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 431
I E + + HG A+ E + E + R E + L + E + AE
Sbjct: 1214 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELS 1266
Query: 432 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG 491
S+ + E RL LQ E A + A AE+ + L Q V + +
Sbjct: 1267 SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1326
Query: 492 -----DENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 546
+ ++ + HD ++ + +A L AG Q E ++
Sbjct: 1327 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1386
Query: 547 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRG 606
TA + +E+ + E+ + R A + + + + D RG
Sbjct: 1387 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1446
Query: 607 --------DSQRLDLENAVLMQELMAMKEE-----MAELKAQLYLLEKEKKALELKLSTR 653
D +DLE + + K+ +AE KA + +E++ E + R
Sbjct: 1447 RRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRER 1506
Query: 654 EAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS---GSKDKPGKECAD------AASPA 704
EA+ + +E + E E+ E++ R+L + SKD GK + A A
Sbjct: 1507 EARALSLTRALEE-EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1565
Query: 705 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQ------S 758
+ + T E+EL A +R E ++A + L+ ++ E R +Q
Sbjct: 1566 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1625
Query: 759 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEE 817
AE D +R L A A+KK + +L++L++QM + + E V+ L++ A ++E
Sbjct: 1626 AEVERDEERKQRTLAVA---ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1681
Score = 43.9 bits (102), Expect = 6e-04
Identities = 73/351 (20%), Positives = 138/351 (39%), Gaps = 52/351 (14%)
Query: 5 VAMKYGNDSSAELSELHSAALASLKGDI-VELNKRLQQTERERDLLEKKLAKAQCEQSHL 63
VA + ND A+++EL A+ + +E+ + +T+ ERDL + A + + L
Sbjct: 1561 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE-RRRQL 1619
Query: 64 MREHEDVQERTTLRYEERITELHSVIA--ELNKKIDRLQGTTIREEDEYSELRSELSQSQ 121
++ D + R EER +V A +L +++ L+ E +L + Q
Sbjct: 1620 AKQLRDAEVE---RDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQ 1676
Query: 122 HEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSC 181
++ E R +++ +TS + N E ++ L GLE
Sbjct: 1677 AQMKELWREVEETRTS--------------REEIFSQNRESEKRLKGLE----------- 1711
Query: 182 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREE 241
AEV R E+L + D A + ++ RD +A+E + A + EE
Sbjct: 1712 ----AEVLRLQEELAAS----DRARRQAQQ-----DRD---EMADEVANGNLSKAAILEE 1755
Query: 242 NESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTST 301
L L EEEL ++ + + +L +V L T L + ++ +
Sbjct: 1756 KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1815
Query: 302 NRPINPSTGELSTSSSS----NDIPIAKIAERVKLSKTRSESSSSDRPVLG 348
R I G L + + + IA + ++ ++ + E + +R + G
Sbjct: 1816 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSG 1866
Score = 36.2 bits (82), Expect = 0.13
Identities = 23/118 (19%), Positives = 61/118 (51%), Gaps = 5/118 (4%)
Query: 21 HSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEE 80
H +A+L+ + + ++L+Q RER L K + +A+ ++ + E+ + R + +
Sbjct: 1837 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVADQLRD 1895
Query: 81 RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSV 138
++ + + + +L ++++ + R + L+ EL +V E + SM+++ T++
Sbjct: 1896 QLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL----EDVTESAESMNREVTTL 1949
Score = 30.8 bits (68), Expect = 5.4
Identities = 25/93 (26%), Positives = 44/93 (47%), Gaps = 8/93 (8%)
Query: 28 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDV--------QERTTLRYE 79
L+ + + N R++Q +R+ + E++ ++AQ + L RE EDV +E TTLR
Sbjct: 1893 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNR 1952
Query: 80 ERITELHSVIAELNKKIDRLQGTTIREEDEYSE 112
R L + + +G EE E ++
Sbjct: 1953 LRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1985
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 81.6 bits (200), Expect = 3e-15
Identities = 182/875 (20%), Positives = 326/875 (37%), Gaps = 119/875 (13%)
Query: 8 KYGNDSSAELSELHSAALASLKGD--IVELNKRLQQTERERDLLEKKLAKAQCEQSHLMR 65
++ + ++ E ++ S LK + I ++ RL++ E+ R LEK + E S L
Sbjct: 1027 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1086
Query: 66 EHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDE---YSELRSELSQSQH 122
+ + Q+R + A+L +K + LQ R EDE ++L L ++Q
Sbjct: 1087 QMVEQQQRA-----------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1135
Query: 123 EVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK----- 177
+ E ++ ++ + + E Q DL EL+ + LE+ +
Sbjct: 1136 ALAEAQEDLESERVARTKAEKQRR----------DLGEELEALRGELEDTLDSTNAQQEL 1185
Query: 178 KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEER---SRWEK- 233
+S V E+ + +E+ T E A++ + + G +L L + R WEK
Sbjct: 1186 RSKREQEVTELKKTLEEETRIHE---AAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1242
Query: 234 ------ELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 287
E++ LR E SL E+ R + + ++ R E +LQ
Sbjct: 1243 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1302
Query: 288 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 347
QA + G L T LS SS + + E ++ +TR++ + R V
Sbjct: 1303 QAELENVSGALNEAES----KTIRLSKELSSTEAQLHDAQELLQ-EETRAKLALGSR-VR 1356
Query: 348 GSEISSIGVSSSVAEHLAH-------------SLQDCSNIQEIFQTLYSHGSAISESKIR 394
E + G+ + E A L + QE G R
Sbjct: 1357 AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1416
Query: 395 EFEVETERLNSR---IEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQY 451
E E T+RL + ++ L+ L L++ + E+ LV E L
Sbjct: 1417 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476
Query: 452 SEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAEN 511
+ + L A+ E E++ G+ R A S +T+ L+ + R+ E
Sbjct: 1477 EKAAV-----LRAVEERERAEAEGREREARALS----------LTRALEEEQEAREELER 1521
Query: 512 AAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE----FTKEDEQ 567
+AL +L+ V G SV E + + A + E ++ +
Sbjct: 1522 QNRALRAELEALLSSKDDV-GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKL 1580
Query: 568 RLKDYIQQLKNDRAAVKLTMLELESIHIDPLSY---DVKPRGDSQRLDLENAVLMQELMA 624
RL+ +Q LK E L+ D + D +R AV ++
Sbjct: 1581 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK--K 1638
Query: 625 MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSS 684
++ E+ ELKAQ+ + K+ +L +AQ ++ L EVEE + R S
Sbjct: 1639 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQ-------MKELWREVEETRTSREEIFSQ 1691
Query: 685 TSSGSKDKPGKEC----ADAASPALSLAELRTTCSENELAAEFTN------AIRREKK-L 733
K G E A A + +E+A E N AI EK+ L
Sbjct: 1692 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1751
Query: 734 KARVQELVSALERLTKSSEIRHQQ------SAEFVNDLKRANSNLVAAYEKAKKKHQNKL 787
+ R+ +L LE +SE+ + + E + A + A E +++ + ++
Sbjct: 1752 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1811
Query: 788 KKLESQM----MAMVERHETQVRMLKQRIALLEEE 818
++L ++ RH+ + L+ ++A EE+
Sbjct: 1812 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1846
Score = 80.9 bits (198), Expect = 5e-15
Identities = 171/839 (20%), Positives = 316/839 (37%), Gaps = 108/839 (12%)
Query: 31 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIA 90
++ EL R+ Q E ER L ++L +A+ E L E E+ + R R +E L V++
Sbjct: 891 EVGELQGRVAQLEEERARLAEQL-RAEAE---LCAEAEETRGRLAARKQE----LELVVS 942
Query: 91 ELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTA 150
EL ++ + + + + E L+ + + + + + + + Q E +
Sbjct: 943 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1002
Query: 151 DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE 210
D+ D NS+L + LE+ + + S AE + ++ L + I +E
Sbjct: 1003 DLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1057
Query: 211 -----------EIEGVLGR------DLYPNLAEERSRWEKELAGLREENESLTAMLCSKE 253
E+E + R +L + E++ R E+ A L + E L A L E
Sbjct: 1058 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1117
Query: 254 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELS 313
+E + ++RE + L E Q L+S + + + + GEL
Sbjct: 1118 DEGGARAQLLKSLREAQAAL----AEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1173
Query: 314 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 373
+ S + A++ SK E L +L++ +
Sbjct: 1174 DTLDSTN------AQQELRSKREQE----------------------VTELKKTLEEETR 1205
Query: 374 IQE--IFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 431
I E + + HG A+ E + E + R E + L + E + AE
Sbjct: 1206 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELS 1258
Query: 432 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG 491
S+ + E RL LQ E A + A AE+ + L Q V + +
Sbjct: 1259 SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1318
Query: 492 -----DENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 546
+ ++ + HD ++ + +A L AG Q E ++
Sbjct: 1319 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1378
Query: 547 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRG 606
TA + +E+ + E+ + R A + + + + D RG
Sbjct: 1379 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1438
Query: 607 --------DSQRLDLENAVLMQELMAMKEE-----MAELKAQLYLLEKEKKALELKLSTR 653
D +DLE + + K+ +AE KA + +E++ E + R
Sbjct: 1439 RRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRER 1498
Query: 654 EAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS---GSKDKPGKECAD------AASPA 704
EA+ + +E + E E+ E++ R+L + SKD GK + A A
Sbjct: 1499 EARALSLTRALEE-EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1557
Query: 705 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQ------S 758
+ + T E+EL A +R E ++A + L+ ++ E R +Q
Sbjct: 1558 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1617
Query: 759 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEE 817
AE D +R L A A+KK + +L++L++QM + + E V+ L++ A ++E
Sbjct: 1618 AEVERDEERKQRTLAVA---ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1673
Score = 43.9 bits (102), Expect = 6e-04
Identities = 73/351 (20%), Positives = 138/351 (39%), Gaps = 52/351 (14%)
Query: 5 VAMKYGNDSSAELSELHSAALASLKGDI-VELNKRLQQTERERDLLEKKLAKAQCEQSHL 63
VA + ND A+++EL A+ + +E+ + +T+ ERDL + A + + L
Sbjct: 1553 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE-RRRQL 1611
Query: 64 MREHEDVQERTTLRYEERITELHSVIA--ELNKKIDRLQGTTIREEDEYSELRSELSQSQ 121
++ D + R EER +V A +L +++ L+ E +L + Q
Sbjct: 1612 AKQLRDAEVE---RDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQ 1668
Query: 122 HEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSC 181
++ E R +++ +TS + N E ++ L GLE
Sbjct: 1669 AQMKELWREVEETRTS--------------REEIFSQNRESEKRLKGLE----------- 1703
Query: 182 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREE 241
AEV R E+L + D A + ++ RD +A+E + A + EE
Sbjct: 1704 ----AEVLRLQEELAAS----DRARRQAQQ-----DRD---EMADEVANGNLSKAAILEE 1747
Query: 242 NESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTST 301
L L EEEL ++ + + +L +V L T L + ++ +
Sbjct: 1748 KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1807
Query: 302 NRPINPSTGELSTSSSS----NDIPIAKIAERVKLSKTRSESSSSDRPVLG 348
R I G L + + + IA + ++ ++ + E + +R + G
Sbjct: 1808 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSG 1858
Score = 36.2 bits (82), Expect = 0.13
Identities = 23/118 (19%), Positives = 61/118 (51%), Gaps = 5/118 (4%)
Query: 21 HSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEE 80
H +A+L+ + + ++L+Q RER L K + +A+ ++ + E+ + R + +
Sbjct: 1829 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVADQLRD 1887
Query: 81 RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSV 138
++ + + + +L ++++ + R + L+ EL +V E + SM+++ T++
Sbjct: 1888 QLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL----EDVTESAESMNREVTTL 1941
Score = 30.8 bits (68), Expect = 5.4
Identities = 25/93 (26%), Positives = 44/93 (47%), Gaps = 8/93 (8%)
Query: 28 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDV--------QERTTLRYE 79
L+ + + N R++Q +R+ + E++ ++AQ + L RE EDV +E TTLR
Sbjct: 1885 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNR 1944
Query: 80 ERITELHSVIAELNKKIDRLQGTTIREEDEYSE 112
R L + + +G EE E ++
Sbjct: 1945 LRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1977
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 81.6 bits (200), Expect = 3e-15
Identities = 182/875 (20%), Positives = 326/875 (37%), Gaps = 119/875 (13%)
Query: 8 KYGNDSSAELSELHSAALASLKGD--IVELNKRLQQTERERDLLEKKLAKAQCEQSHLMR 65
++ + ++ E ++ S LK + I ++ RL++ E+ R LEK + E S L
Sbjct: 1068 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1127
Query: 66 EHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDE---YSELRSELSQSQH 122
+ + Q+R + A+L +K + LQ R EDE ++L L ++Q
Sbjct: 1128 QMVEQQQRA-----------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1176
Query: 123 EVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK----- 177
+ E ++ ++ + + E Q DL EL+ + LE+ +
Sbjct: 1177 ALAEAQEDLESERVARTKAEKQRR----------DLGEELEALRGELEDTLDSTNAQQEL 1226
Query: 178 KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEER---SRWEK- 233
+S V E+ + +E+ T E A++ + + G +L L + R WEK
Sbjct: 1227 RSKREQEVTELKKTLEEETRIHE---AAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1283
Query: 234 ------ELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSV 287
E++ LR E SL E+ R + + ++ R E +LQ
Sbjct: 1284 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1343
Query: 288 QATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVL 347
QA + G L T LS SS + + E ++ +TR++ + R V
Sbjct: 1344 QAELENVSGALNEAES----KTIRLSKELSSTEAQLHDAQELLQ-EETRAKLALGSR-VR 1397
Query: 348 GSEISSIGVSSSVAEHLAH-------------SLQDCSNIQEIFQTLYSHGSAISESKIR 394
E + G+ + E A L + QE G R
Sbjct: 1398 AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1457
Query: 395 EFEVETERLNSR---IEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQY 451
E E T+RL + ++ L+ L L++ + E+ LV E L
Sbjct: 1458 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1517
Query: 452 SEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAEN 511
+ + L A+ E E++ G+ R A S +T+ L+ + R+ E
Sbjct: 1518 EKAAV-----LRAVEERERAEAEGREREARALS----------LTRALEEEQEAREELER 1562
Query: 512 AAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE----FTKEDEQ 567
+AL +L+ V G SV E + + A + E ++ +
Sbjct: 1563 QNRALRAELEALLSSKDDV-GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKL 1621
Query: 568 RLKDYIQQLKNDRAAVKLTMLELESIHIDPLSY---DVKPRGDSQRLDLENAVLMQELMA 624
RL+ +Q LK E L+ D + D +R AV ++
Sbjct: 1622 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK--K 1679
Query: 625 MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSS 684
++ E+ ELKAQ+ + K+ +L +AQ ++ L EVEE + R S
Sbjct: 1680 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQ-------MKELWREVEETRTSREEIFSQ 1732
Query: 685 TSSGSKDKPGKEC----ADAASPALSLAELRTTCSENELAAEFTN------AIRREKK-L 733
K G E A A + +E+A E N AI EK+ L
Sbjct: 1733 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1792
Query: 734 KARVQELVSALERLTKSSEIRHQQ------SAEFVNDLKRANSNLVAAYEKAKKKHQNKL 787
+ R+ +L LE +SE+ + + E + A + A E +++ + ++
Sbjct: 1793 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1852
Query: 788 KKLESQM----MAMVERHETQVRMLKQRIALLEEE 818
++L ++ RH+ + L+ ++A EE+
Sbjct: 1853 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1887
Score = 80.9 bits (198), Expect = 5e-15
Identities = 171/839 (20%), Positives = 316/839 (37%), Gaps = 108/839 (12%)
Query: 31 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIA 90
++ EL R+ Q E ER L ++L +A+ E L E E+ + R R +E L V++
Sbjct: 932 EVGELQGRVAQLEEERARLAEQL-RAEAE---LCAEAEETRGRLAARKQE----LELVVS 983
Query: 91 ELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTA 150
EL ++ + + + + E L+ + + + + + + + Q E +
Sbjct: 984 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1043
Query: 151 DMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVE 210
D+ D NS+L + LE+ + + S AE + ++ L + I +E
Sbjct: 1044 DLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1098
Query: 211 -----------EIEGVLGR------DLYPNLAEERSRWEKELAGLREENESLTAMLCSKE 253
E+E + R +L + E++ R E+ A L + E L A L E
Sbjct: 1099 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1158
Query: 254 EELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELS 313
+E + ++RE + L E Q L+S + + + + GEL
Sbjct: 1159 DEGGARAQLLKSLREAQAAL----AEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1214
Query: 314 TSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSN 373
+ S + A++ SK E L +L++ +
Sbjct: 1215 DTLDSTN------AQQELRSKREQE----------------------VTELKKTLEEETR 1246
Query: 374 IQE--IFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 431
I E + + HG A+ E + E + R E + L + E + AE
Sbjct: 1247 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKGAWEKTR-----LALEAEVSELRAELS 1299
Query: 432 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG 491
S+ + E RL LQ E A + A AE+ + L Q V + +
Sbjct: 1300 SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1359
Query: 492 -----DENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 546
+ ++ + HD ++ + +A L AG Q E ++
Sbjct: 1360 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1419
Query: 547 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRG 606
TA + +E+ + E+ + R A + + + + D RG
Sbjct: 1420 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1479
Query: 607 --------DSQRLDLENAVLMQELMAMKEE-----MAELKAQLYLLEKEKKALELKLSTR 653
D +DLE + + K+ +AE KA + +E++ E + R
Sbjct: 1480 RRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRER 1539
Query: 654 EAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS---GSKDKPGKECAD------AASPA 704
EA+ + +E + E E+ E++ R+L + SKD GK + A A
Sbjct: 1540 EARALSLTRALEE-EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1598
Query: 705 LSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQ------S 758
+ + T E+EL A +R E ++A + L+ ++ E R +Q
Sbjct: 1599 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRD 1658
Query: 759 AEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEE 817
AE D +R L A A+KK + +L++L++QM + + E V+ L++ A ++E
Sbjct: 1659 AEVERDEERKQRTLAVA---ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1714
Score = 43.9 bits (102), Expect = 6e-04
Identities = 73/351 (20%), Positives = 138/351 (39%), Gaps = 52/351 (14%)
Query: 5 VAMKYGNDSSAELSELHSAALASLKGDI-VELNKRLQQTERERDLLEKKLAKAQCEQSHL 63
VA + ND A+++EL A+ + +E+ + +T+ ERDL + A + + L
Sbjct: 1594 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE-RRRQL 1652
Query: 64 MREHEDVQERTTLRYEERITELHSVIA--ELNKKIDRLQGTTIREEDEYSELRSELSQSQ 121
++ D + R EER +V A +L +++ L+ E +L + Q
Sbjct: 1653 AKQLRDAEVE---RDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQ 1709
Query: 122 HEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSC 181
++ E R +++ +TS + N E ++ L GLE
Sbjct: 1710 AQMKELWREVEETRTS--------------REEIFSQNRESEKRLKGLE----------- 1744
Query: 182 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREE 241
AEV R E+L + D A + ++ RD +A+E + A + EE
Sbjct: 1745 ----AEVLRLQEELAAS----DRARRQAQQ-----DRD---EMADEVANGNLSKAAILEE 1788
Query: 242 NESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTST 301
L L EEEL ++ + + +L +V L T L + ++ +
Sbjct: 1789 KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1848
Query: 302 NRPINPSTGELSTSSSS----NDIPIAKIAERVKLSKTRSESSSSDRPVLG 348
R I G L + + + IA + ++ ++ + E + +R + G
Sbjct: 1849 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSG 1899
Score = 36.2 bits (82), Expect = 0.13
Identities = 23/118 (19%), Positives = 61/118 (51%), Gaps = 5/118 (4%)
Query: 21 HSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEE 80
H +A+L+ + + ++L+Q RER L K + +A+ ++ + E+ + R + +
Sbjct: 1870 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVADQLRD 1928
Query: 81 RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSV 138
++ + + + +L ++++ + R + L+ EL +V E + SM+++ T++
Sbjct: 1929 QLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL----EDVTESAESMNREVTTL 1982
Score = 30.8 bits (68), Expect = 5.4
Identities = 25/93 (26%), Positives = 44/93 (47%), Gaps = 8/93 (8%)
Query: 28 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDV--------QERTTLRYE 79
L+ + + N R++Q +R+ + E++ ++AQ + L RE EDV +E TTLR
Sbjct: 1926 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNR 1985
Query: 80 ERITELHSVIAELNKKIDRLQGTTIREEDEYSE 112
R L + + +G EE E ++
Sbjct: 1986 LRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 2018
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 80.9 bits (198), Expect = 5e-15
Identities = 169/903 (18%), Positives = 349/903 (38%), Gaps = 126/903 (13%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+A++K + + L ++E +R LE+K+ E++ L + + + + EER +
Sbjct: 852 MATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEAD-SLADAEERCEQ 910
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
L +L KI + EE+ +EL ++ + + E +E + +D + +++ E +
Sbjct: 911 LIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 970
Query: 145 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDL 204
+ N L + GL+ + K +L + ++ L + ++
Sbjct: 971 KHATENKVKN-------LTEEMAGLDETIAKLSKEKKALQETH-QQTLDDLQAEEDKVNI 1022
Query: 205 AIKT-------VEEIEGVLGRDLYPNLAEERSRWEKE---------LAGLREENESLTAM 248
K V+++EG L ++ + ER++ + E + + + L
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 249 LCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPS 308
L KE E++ + + + +L+++++ELQ R++ + + + +
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142
Query: 309 TGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS-----DRPVLGSEISSIGVSSSVAEH 363
+ EL S + + +V+L+K R + L E + A+
Sbjct: 1143 SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADS 1202
Query: 364 LAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEE 423
+A + N+Q + Q L E + E ++ET+ L+S E + L +
Sbjct: 1203 MAELGEQIDNLQRVKQKL--------EKEKSELKMETDDLSSNAEAISKAKGNLE---KM 1251
Query: 424 CKSNAERMSMLVGKYE------SNATALRLALQ-----YSEQCIEAYELLLALAESEQSL 472
C+S +++S L K E ++ TA R LQ YS Q E L+ L+ S+Q+
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQA- 1310
Query: 473 ILGQFRAAGVGSSPGDQSGDENITQMLKRAHDC-----RKTAENAAKALLMKLDGSCGGA 527
Q ++ + + HDC + E KA L + A
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR-------A 1363
Query: 528 FAVAGCSVQPW-------------------ESLSSNSHTSTTSSTASSCDTEFTKEDEQR 568
+ A V W + L+ + A + ++ +QR
Sbjct: 1364 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQR 1423
Query: 569 LKDYIQQLKND--RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDL-----ENAVLMQE 621
L++ ++ L D R+ L+ + + D + + K + + + +L E+ L E
Sbjct: 1424 LQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTE 1483
Query: 622 LMAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVH-IEHLKSEVEEQKEQR 678
L +K E QL L +E K L+ ++S T + E +H +E +K +VE++K +
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543
Query: 679 MRSLSSTSSGSKDKPGK-----------------ECADAASPALSLAELRTTCSE---NE 718
+L + + + GK + A+ L T E +
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQST 1603
Query: 719 LAAEF---TNAIRREKKLKARVQEL---VSALERLTKSSEIRHQQSAEFVNDLKRANSNL 772
L AE +A+R +KK++ + E+ ++ RL S ++ + + + + +
Sbjct: 1604 LDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA 1663
Query: 773 VAAYEKAK------KKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNE 826
+ E K ++ N L+ ++ A +E+ E ++ +Q + E HT
Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 827 TSL 829
TSL
Sbjct: 1724 TSL 1726
Score = 49.3 bits (116), Expect = 1e-05
Identities = 113/612 (18%), Positives = 234/612 (38%), Gaps = 59/612 (9%)
Query: 232 EKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQ--- 288
EKE+A ++EE + ++EL +++A + E+ L + +LQ ++QS
Sbjct: 849 EKEMATMKEEFQ-------KTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901
Query: 289 ATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLG 348
A +L + E++ + + +I + K + E S+ L
Sbjct: 902 ADAEERCEQLIKNKIQLEAKIKEVTERAEEEE----EINAELTAKKRKLEDECSE---LK 954
Query: 349 SEISSIGVSSSVAEHLAHSLQD-CSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRI 407
+I + ++ + E H+ ++ N+ E L + +S+ K + E +
Sbjct: 955 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEK----KALQETHQQTL 1010
Query: 408 EHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAE 467
+ L+++ D + I + +++ L G E LR+ L+ +++ +E +L LA
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQE-KKLRMDLERAKRKLEG-DLKLAQES 1068
Query: 468 S----------EQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALL 517
+ ++ L +F + + S D+ E Q+ K+ + + E + +
Sbjct: 1069 TMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVE--IQLQKKIKELQARIEELGEEIE 1126
Query: 518 MKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK 577
+ + S L S + A+S E K+ E + + L+
Sbjct: 1127 AERASRAKAEKQRSDLS----RELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLE 1182
Query: 578 NDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLY 637
+ + L H D ++ + + QR+ + L +E +K E +L +
Sbjct: 1183 EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQK---LEKEKSELKMETDDLSSNAE 1239
Query: 638 LLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-----QRMRSLSSTSSGSKDK 692
+ K K LE + E Q + LK++ EEQ+ R+ T +G +
Sbjct: 1240 AISKAKGNLEKMCRSLEDQ-------VSELKTKEEEQQRLINDLTAQRARLQTEAGEYSR 1292
Query: 693 PGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSE 752
E DA LS ++ +T EL + + + L +Q + L + E
Sbjct: 1293 QLDE-KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYE 1351
Query: 753 IRHQQSAEFVNDLKRANSNLV---AAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLK 809
+ AE L +ANS + YE + +L++ + ++ ++ E V +
Sbjct: 1352 EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVN 1411
Query: 810 QRIALLEEENSR 821
+ A LE+ R
Sbjct: 1412 AKCASLEKTKQR 1423
Score = 49.3 bits (116), Expect = 1e-05
Identities = 87/428 (20%), Positives = 179/428 (41%), Gaps = 47/428 (10%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQC--EQSHLMREHEDVQE-RTTLRYEER 81
++ L I E K++ + E+ + +E++ + Q E++ EHE+ + R L +
Sbjct: 1512 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV 1571
Query: 82 ITELHSVIAELNKKIDRLQGTTIRE-EDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSI 140
+E+ IAE +++ID+L+ R E S L +E+ +S+++ + M+ D + I
Sbjct: 1572 KSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI-RSRNDALRVKKKMEGDLNEMEI 1630
Query: 141 PENQSTMVTAD-MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAE-----VDRHIEQ 194
N + + A+ + N + L+ L++ + G++ L++ E + IE+
Sbjct: 1631 QLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEE 1690
Query: 195 LTTASEHCDLAIKTVEE-----IEGV-LGRDLYPNLAEERSRWEKELAGLREENESLTAM 248
L E + + K E+ E V L +L + + E +++ L+ E E +
Sbjct: 1691 LWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQE 1750
Query: 249 LCSKEEELNR--TKATMNA--IREERD----------RLRRRVRELQTRL-QSVQATGPS 293
+ EE+ + T A M A +++E+D L + V++LQ RL ++ Q
Sbjct: 1751 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1810
Query: 294 SPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDR--------- 344
++ + GE+ N + + + + K + + DR
Sbjct: 1811 GKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDL 1870
Query: 345 -PVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERL 403
L +++ S + AE Q +N+ + + + A + I E +V R+
Sbjct: 1871 VDKLQAKVKSYKRQAEEAEE-----QSNANLSKFRKLQHELEEAEERADIAESQVNKLRV 1925
Query: 404 NSRIEHLK 411
SR H K
Sbjct: 1926 KSREVHTK 1933
Score = 48.1 bits (113), Expect = 3e-05
Identities = 56/232 (24%), Positives = 107/232 (46%), Gaps = 31/232 (13%)
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 650
L + +KP S + E A + +E K+E+A EL+ ++ L KEK L+L++
Sbjct: 835 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894
Query: 651 -----STREAQEQA-----YLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADA 700
S +A+E+ + +E EV E+ E+ +++ + K K EC++
Sbjct: 895 QSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEE-EEINAELTAKKRKLEDECSEL 953
Query: 701 ASPALSLAELRTTCSENELAAEFT-NAIRREKKLKARVQELVSALERLTKSSEIRHQQSA 759
+ +L T ++ E T N ++ + A + E ++ L + K+ + HQQ+
Sbjct: 954 KK---DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQT- 1009
Query: 760 EFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 811
++DL +A + V KAK K + ++ LE + E ++RM +R
Sbjct: 1010 --LDDL-QAEEDKVNILTKAKTKLEQQVDDLEGSL-----EQEKKLRMDLER 1053
Score = 42.0 bits (97), Expect = 0.002
Identities = 46/265 (17%), Positives = 115/265 (43%), Gaps = 18/265 (6%)
Query: 28 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 87
L+ +I EL L+QTER R + E++L A E+ L+ T + E +++L S
Sbjct: 1684 LQAEIEELWATLEQTERSRKIAEQELLDAS-ERVQLLHTQNTSLINTKKKLENDVSQLQS 1742
Query: 88 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQH---EVNEDSRSMDQDQTSVS--IPE 142
+ E+ ++ + + + + + EL + Q + ++++Q + + E
Sbjct: 1743 EVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1802
Query: 143 NQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHC 202
+ + L + ++ + +EN ++ + + + +R +++LT +E
Sbjct: 1803 AEQLALKGGKKQIQKLEARVRELEGEVENEQ--KRNAEAVKGLRKHERRVKELTYQTE-- 1858
Query: 203 DLAIKTVEEIEGVLG-RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 261
E+ + VL +DL L + ++++ E++ + + + EL +
Sbjct: 1859 -------EDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEE 1911
Query: 262 TMNAIREERDRLRRRVRELQTRLQS 286
+ + ++LR + RE+ T++ +
Sbjct: 1912 RADIAESQVNKLRVKSREVHTKISA 1936
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 80.9 bits (198), Expect = 5e-15
Identities = 179/828 (21%), Positives = 324/828 (39%), Gaps = 81/828 (9%)
Query: 28 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 87
L+ + L +LQQ + ER L KL +Q E S L + Q++ L E R+ L
Sbjct: 536 LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARV-RLQG 594
Query: 88 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHE-VNEDSR-----------SMDQDQ 135
+A + G + E L +L+++QH + E R +DQ+
Sbjct: 595 EMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEA 654
Query: 136 TSVSIPENQSTMVTADMDN-CSDLNSELQRVLTGLENVVCGRKK-SSCSLSVAEVDRHIE 193
+ I E + TMV D+ + E +R+ ++ ++ L++ + D+ +E
Sbjct: 655 AFMQIQEAK-TMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLE 713
Query: 194 QLTTASEHCDLAIKTVEEIEGVLGRDLYPN-LAEERSRWEKELAGLREENESLTAMLCSK 252
L EH DL + E + R+ + L + L L+ E S +C
Sbjct: 714 ALQ--QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLL 771
Query: 253 EEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGEL 312
+ E +A + A + ++ L R R L+ + T L + + L
Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVE----HL 827
Query: 313 STSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCS 372
+++ + KI E+ K E+ D IS + + + L L++
Sbjct: 828 QQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL---KATRKRLDSELKELR 884
Query: 373 NIQEIFQTLYSHGSAISESKIREFEVETER-----LNSRIEHLKSQNDLLTITLEECKSN 427
QE+ Q +A +E EV R L ++ + + D + L+ + +
Sbjct: 885 --QELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFD 942
Query: 428 AERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLI-LGQFRAAGVGSSP 486
E+M V E+N AL+ ++ +Q E A+ E +Q + LG +
Sbjct: 943 KEQM---VAVTEANE-ALKKQIEELQQ-----EARKAITEQKQKMRRLGSDLTSAQKEMK 993
Query: 487 GDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCS--VQPWES-LSS 543
EN +L R A+ AA A L +L G + + +Q E+ L +
Sbjct: 994 TKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQA 1053
Query: 544 NSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVK 603
SH+ T KE ++ + Q+L+ R V LELE D L
Sbjct: 1054 VSHSKTL----------LEKELQEVIALTSQELEESREKV----LELE----DELQESRG 1095
Query: 604 PRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH 663
R +RL+ N L EL K ++ L L + LE L+ REA +
Sbjct: 1096 FRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQ 1155
Query: 664 IEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEF 723
++ + EE+ +++M+ L S +K KE ++ ++ A++ + A
Sbjct: 1156 VQAVLQRKEEE-DRQMKHLVQALQASLEKE-KEKVNSLKEQVAAAKVEAGHNRRHFKAAS 1213
Query: 724 TNAIRREKKLKARVQELVSALERLTKSSEIRH----QQSAEFVNDLKRANSNLVAAYEKA 779
+K+L+A+ + LV L+ +IR Q+ A+F +L A + L +
Sbjct: 1214 LELSEVKKELQAK-EHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQL----QLL 1268
Query: 780 KKKHQNKLKKLESQMMAM------VERHETQVRMLKQRIALLEEENSR 821
+K+ +L K M V++ E +++ LKQ++ L E++ +
Sbjct: 1269 QKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRK 1316
Score = 78.6 bits (192), Expect = 2e-14
Identities = 162/756 (21%), Positives = 304/756 (40%), Gaps = 142/756 (18%)
Query: 23 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERI 82
A L L+G+ + + E+ +LE L A+ + L R ++E T E +
Sbjct: 752 ARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTE-ETSETL 810
Query: 83 TELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEV---NEDSRSMDQDQTSVS 139
+L +A + +++ LQ T + + +++ + Q + V D+ S DQ
Sbjct: 811 EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQ-----L 865
Query: 140 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS 199
I E ++T D + +L EL + V G K++ + AE+ R ++
Sbjct: 866 ISELKATRKRLDSE-LKELRQELMQ--------VHGEKRT----AEAELSRLHREVAQVR 912
Query: 200 EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRT 259
+H + ++EG L + +ER E L L+ + E + A+ + E
Sbjct: 913 QH-------MADLEGHL-----QSAQKERDEMETHLQSLQFDKEQMVAVTEANE------ 954
Query: 260 KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSN 319
A I E + R+ + E + +++ + + S+ + + ++ + G L S
Sbjct: 955 -ALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGIL--SRRLQ 1011
Query: 320 DIPIAKIAERVKLSKTRSESSSSDRPV-LGSEISSIGVSSSVAEHLAHSLQDCSNIQEIF 378
+ AK A +L + R++ SSD + L I ++ H L+ +E+
Sbjct: 1012 EALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLE-----KELQ 1066
Query: 379 QTLYSHGSAISESKIREFEVETERLNSR-----IEHLKSQNDLLTITLEECKSNAERMSM 433
+ + + ES+ + E+E E SR I+ L+ N L + LE K
Sbjct: 1067 EVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK------ 1120
Query: 434 LVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGD- 492
L G +SNA AL+ +E ALA+ E L+ + V ++
Sbjct: 1121 LTGLGQSNA-----ALREHNSILET-----ALAKREADLVQLNLQVQAVLQRKEEEDRQM 1170
Query: 493 ENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSS 552
+++ Q L+ + + K N+ K VA V E+ + H
Sbjct: 1171 KHLVQALQASLEKEKEKVNSLKE-------------QVAAAKV---EAGHNRRHFK---- 1210
Query: 553 TASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLD 612
A+S + K++ Q + +Q+L + ++ L
Sbjct: 1211 -AASLELSEVKKELQAKEHLVQKL----------------------------QAEADDLQ 1241
Query: 613 LENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVE 672
+ QE+ + E+AE +AQL LL+K+ L+ +LS + Q +E+LK EV
Sbjct: 1242 IREGKHSQEIAQFQAELAEARAQLQLLQKQ---LDEQLSKQPVGNQ----EMENLKWEV- 1293
Query: 673 EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREK- 731
+QKE+ ++SL ++ + KE L+ SE E+A E + +++K
Sbjct: 1294 DQKEREIQSLKQQLDLTEQQGRKELEGLQQ------LLQNVKSELEMAQEDLSMTQKDKF 1347
Query: 732 KLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKR 767
L+A+V EL + ++ L QQ+ + DL+R
Sbjct: 1348 MLQAKVSELKNNMKTLL-------QQNQQLKLDLRR 1376
Score = 73.9 bits (180), Expect = 6e-13
Identities = 149/816 (18%), Positives = 330/816 (40%), Gaps = 82/816 (10%)
Query: 46 RDLLEKKLAKAQCEQSHLMREHEDVQER--TTLRYEERITELHSVIAELNKKIDRLQGTT 103
+D+L+ A+ Q + + E ++ +++ E E + ++ K+ RL+G
Sbjct: 362 KDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQL 421
Query: 104 IREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQ 163
E S+ E ++ Q ++ S + + + +++++D +L+
Sbjct: 422 EALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLE 481
Query: 164 RVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIE-GVLGRD-LY 221
R +T L+N++ + S S + L A E + VE+++ +L +D
Sbjct: 482 RAMTDLQNMLEAKNASLASSN--------NDLQVAEEQYQRLMAKVEDMQRSMLSKDNTV 533
Query: 222 PNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQ 281
+L ++ + + +L ++ E +LT+ L + + E+ +++ ++R+ + +E +
Sbjct: 534 HDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEI----SSLQSVRQWYQQQLALAQEAR 589
Query: 282 TRLQSVQA---TGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSE 338
RLQ A G + L + N S + T + + K R+ E
Sbjct: 590 VRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSM---KEKGRIAAQLQGIE 646
Query: 339 SSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEV 398
+ D+ +I + V E L L++ +E Q + + +A E ++ + ++
Sbjct: 647 ADMLDQEAAFMQIQE--AKTMVEEDLQRRLEEFEGERERLQRM-ADSAASLEQQLEQVKL 703
Query: 399 ETERLNSRIEHLKSQN-DL---LTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQ 454
+ + ++E L+ ++ DL LT+T E +S + + L Y+ L+ L +
Sbjct: 704 TLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDE----LQARLGELQG 759
Query: 455 CIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAK 514
+ E + L ++E+ ++ +AA +SG E + + +R + + +
Sbjct: 760 EAASREDTICLLQNEKIILEAALQAA--------KSGKEELDRGARRLEEGTEETSETLE 811
Query: 515 ALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQ 574
L +L G + Q +L E + D I
Sbjct: 812 KLREELAIKSGQVEHLQ----QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLIS 867
Query: 575 QLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKA 634
+LK R + + EL ++ G+ + + E + L +E+ +++ MA+L+
Sbjct: 868 ELKATRKRLDSELKELR-------QELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEG 920
Query: 635 QLYLLEKEKKALELKLSTREAQE----------QAYLVHIEHLKSE----VEEQKEQRMR 680
L +KE+ +E L + + + +A IE L+ E + EQK++ R
Sbjct: 921 HLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRR 980
Query: 681 SLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRRE-------KKL 733
S +S K+ K A + + L+ + E A +R + L
Sbjct: 981 LGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLAL 1040
Query: 734 KARVQELVSALERLTKSSEIRHQQSAEFV----NDLKRANSNLVAAYEKAKKKH--QNKL 787
R+Q L + L+ ++ S + ++ E + +L+ + ++ ++ ++ + K+
Sbjct: 1041 HERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKI 1100
Query: 788 KKLE--SQMMAMVERHET-QVRMLKQRIALLEEENS 820
K+LE ++ +A+ HE ++ L Q A L E NS
Sbjct: 1101 KRLEESNKKLALELEHEKGKLTGLGQSNAALREHNS 1136
Score = 61.2 bits (147), Expect = 4e-09
Identities = 88/458 (19%), Positives = 185/458 (40%), Gaps = 24/458 (5%)
Query: 13 SSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQE 72
+ AELS LH +A ++ + +L LQ ++ERD +E L Q ++ ++ E E
Sbjct: 897 AEAELSRLHRE-VAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTE-ANE 954
Query: 73 RTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMD 132
+ EE E I E +K+ RL G+ + + E++++ ++ V SR +
Sbjct: 955 ALKKQIEELQQEARKAITEQKQKMRRL-GSDLTSAQK--EMKTKHKAYENAVGILSRRLQ 1011
Query: 133 QDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHI 192
+ + + + + A SD + L + LE + + S S +++ +
Sbjct: 1012 EALAAKEAADAELGQLRAQ-GGSSDSSLALHERIQALE-----AELQAVSHSKTLLEKEL 1065
Query: 193 EQ-LTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCS 251
++ + S+ + + + V E+E L +E + K++ L E N+ L L
Sbjct: 1066 QEVIALTSQELEESREKVLELEDEL---------QESRGFRKKIKRLEESNKKLALELEH 1116
Query: 252 KEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGE 311
++ +L + A+RE L + + + L + + R +R +
Sbjct: 1117 EKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQA 1176
Query: 312 LSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDC 371
L S + + E+V +K + + E+S + EHL LQ
Sbjct: 1177 LQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAE 1236
Query: 372 SNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 431
++ +I + +S A ++++ E + + L +++ S+ + +E K ++
Sbjct: 1237 ADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQK 1296
Query: 432 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESE 469
+ +S L L Q + +E + LL +SE
Sbjct: 1297 ER---EIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSE 1331
Score = 38.9 bits (89), Expect = 0.020
Identities = 79/427 (18%), Positives = 169/427 (39%), Gaps = 64/427 (14%)
Query: 16 ELSELHSAALASLKGDIVELNKRLQQTERERDLLE------KKLA-KAQCEQSHL----- 63
E+ L S L + ++EL LQ++ R ++ KKLA + + E+ L
Sbjct: 1067 EVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQ 1126
Query: 64 ----MREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQ 119
+REH + E + E + +L+ ++Q R+E+E +++ +
Sbjct: 1127 SNAALREHNSILETALAKREADLVQLNL----------QVQAVLQRKEEEDRQMKHLVQA 1176
Query: 120 SQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKS 179
Q + ++ ++ + V+ + ++ S SE+++ L E++V +
Sbjct: 1177 LQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAE 1236
Query: 180 SCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLR 239
+ L + E +H +++ A ++ ++ L L K+ G
Sbjct: 1237 ADDLQIRE-GKHSQEIAQFQAELAEARAQLQLLQKQLDEQL-----------SKQPVG-N 1283
Query: 240 EENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLT 299
+E E+L + KE E+ K ++ ++ R+ + LQ LQ+V++ + L+
Sbjct: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG---RKELEGLQQLLQNVKSELEMAQEDLS 1340
Query: 300 STNRP---INPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGV 356
T + + EL + + + + +++KL R + + P G
Sbjct: 1341 MTQKDKFMLQAKVSELKNNMKT----LLQQNQQLKLDLRRGAAKTRKEPK--------GE 1388
Query: 357 SSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDL 416
+SS + DC + + L A+S+ ++ LNS ++ LK + D
Sbjct: 1389 ASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLK-------NLNSCLQQLKQEMDS 1441
Query: 417 LTITLEE 423
L +EE
Sbjct: 1442 LQRQMEE 1448
Score = 36.2 bits (82), Expect = 0.13
Identities = 63/310 (20%), Positives = 126/310 (40%), Gaps = 54/310 (17%)
Query: 13 SSAELSELHS---AALASLKGDIVELNKRLQ---QTERERDLLEKKLAKAQCEQSHLMRE 66
S+A L E +S ALA + D+V+LN ++Q Q + E D K L +A Q+ L +E
Sbjct: 1127 SNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQAL--QASLEKE 1184
Query: 67 HEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNE 126
+E++ L +A + + E SE++ EL +H V +
Sbjct: 1185 ------------KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQK 1232
Query: 127 DSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVA 186
D Q + A++ ++ ++LQ + L+ + + + +
Sbjct: 1233 LQAEADDLQIREGKHSQEIAQFQAEL---AEARAQLQLLQKQLDEQLSKQPVGNQEMENL 1289
Query: 187 --EVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENES 244
EVD+ ++ + + D L E++ R KEL GL++ ++
Sbjct: 1290 KWEVDQKEREIQSLKQQLD--------------------LTEQQGR--KELEGLQQLLQN 1327
Query: 245 LTAMLCSKEEELNRT-------KATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGR 297
+ + L +E+L+ T +A ++ ++ L ++ ++L+ L+ A P
Sbjct: 1328 VKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKG 1387
Query: 298 LTSTNRPINP 307
S++ P P
Sbjct: 1388 EASSSNPATP 1397
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 80.1 bits (196), Expect = 8e-15
Identities = 150/811 (18%), Positives = 322/811 (39%), Gaps = 97/811 (11%)
Query: 28 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 87
++G++ E+ ++ QQ E+++L ++L ++ L E E+++ R + +E L
Sbjct: 871 VEGELEEMERKHQQLLEEKNILAEQLQA----ETELFAEAEEMRARLAAKKQE----LEE 922
Query: 88 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTM 147
++ +L +++ + ++E ++++ + + +++E+ + + Q E +
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 148 VTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIK 207
+ ++ D NS+ + +E+ + + CS +AE + + L ++ I
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRI-----AECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 208 TVEEI---EGVLGRDLYP---NLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKA 261
+EE E ++L L E + + ++A L+ + + L L KEEEL A
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097
Query: 262 TMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDI 321
+ ++ + VRELQ ++ +Q
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQ--------------------------------- 1124
Query: 322 PIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTL 381
+ E K S+ ++E D L E+ E L L+D + Q L
Sbjct: 1125 ---EDFESEKASRNKAEKQKRD---LSEEL----------EALKTELEDTLDTTAAQQEL 1168
Query: 382 YSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESN 441
+ + E ET+ ++I+ ++ ++ LEE E+ E N
Sbjct: 1169 RTKREQEVAELKKALEEETKNHEAQIQDMRQRH---ATALEELSEQLEQAKRFKANLEKN 1225
Query: 442 ATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKR 501
L + ++ + + A +E ++ + Q + S GD+ ++ ++
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR----VELAEK 1281
Query: 502 AHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQ-PWESLSSNSHTSTTSSTASSCDTE 560
A + +N + L++ G FA S++ + T S
Sbjct: 1282 ASKLQNELDNV--STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339
Query: 561 FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQ 620
+E++ L++ ++ + R ++ +L L+S D G + L+ L++
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 621 ELMAMKEEMAELKAQLYLLEKEKKALELKLS--TREAQEQAYLVHIEHLKSEVEEQKEQR 678
+ A+ + + E LEK K L+ +L T + Q + K + +Q
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459
Query: 679 MRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQ 738
+S+S+ + +D+ E + + ALSLA R E EF R+ K+L+A ++
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLA--RALEEALEAKEEFE---RQNKQLRADME 1514
Query: 739 ELVSA-------LERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLE 791
+L+S+ + L KS QQ E L+ L A E AK + + ++ ++
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT-EDAKLRLEVNMQAMK 1573
Query: 792 SQ----MMAMVERHETQVRMLKQRIALLEEE 818
+Q + E++E + R+L +++ LE E
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Score = 75.9 bits (185), Expect = 1e-13
Identities = 156/844 (18%), Positives = 325/844 (38%), Gaps = 98/844 (11%)
Query: 28 LKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 87
L+ I EL + + + R+ EK+ E L E ED + T + E R T+
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR-TKREQ 1174
Query: 88 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTM 147
+AEL K ++ T E + ++R + + E++E + + ++ +N+ +
Sbjct: 1175 EVAELKKALEE---ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE--KNKQGL 1229
Query: 148 VTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS-EHCDLAI 206
T + + ++ LQ+V E+ K+ V E+ + + E + A
Sbjct: 1230 ETDNKELACEVKV-LQQVKAESEH-----KRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 207 KTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAI 266
K E++ V L ++ ++ K+ A L + + +L + + + + +
Sbjct: 1284 KLQNELDNV--STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 267 REERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAK- 325
EE++ L+ + E + ++++ + +L T + ++ G + + + +
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 326 --IAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNI---QEIFQT 380
+++R++ + + L E+ + V L H Q SN+ Q+ F
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD------LDHQRQVASNLEKKQKKFDQ 1455
Query: 381 LYSHGSAIS----------ESKIREFEVETERLNSRIEH-------LKSQNDLLTITLEE 423
L + +IS E++ RE E + L +E + QN L +E+
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 424 CKSNAERMSMLVGKYESNATAL-------RLALQYSEQCIEAYELLLALAESEQSLILGQ 476
S+ + + V + E + AL R L+ E ++A E E + Q
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575
Query: 477 FRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQ 536
F D+ +E ++K+ + E+ K A AVA
Sbjct: 1576 FER---DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR----------ALAVA----- 1617
Query: 537 PWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKD-YIQQLKNDRAAVKLTMLELESIHI 595
S D E E + +D I+QL+ +A +K ELE
Sbjct: 1618 -----------SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 596 DPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREA 655
+ + ++L A E++ ++EE+A + E+E+ L +++ +
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEA----EILQLQEELASSERARRHAEQERDELADEITNSAS 1722
Query: 656 QEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCS 715
+ A L L++ + Q E+ + S D+ K + LA R+
Sbjct: 1723 GKSALLDEKRRLEARIA-QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781
Query: 716 ENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAA 775
+++ A + R+ K+LKA++QEL A++ K++ + + + + AA
Sbjct: 1782 KSDNARQQLE--RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1839
Query: 776 YEKAKKKHQNKLKKL----------ESQMMAMVERHETQVRMLKQRIALLEEENSRPHTN 825
K ++ + KLK++ Q +E+ +++ LK+++ EEE +R + +
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 826 ETSL 829
L
Sbjct: 1900 RRKL 1903
Score = 63.2 bits (152), Expect = 1e-09
Identities = 129/694 (18%), Positives = 271/694 (39%), Gaps = 89/694 (12%)
Query: 26 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 85
ASL+ + + + LQ+ R++ L ++ + + E++ L + E+ +E E+++ L
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE-EEEARKNLEKQVLAL 1369
Query: 86 HSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQS 145
S +A+ KK+D GT E+ +L + + E + + D+ + + + + +
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429
Query: 146 TMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLA 205
+T D+D+ + S L++ + ++ K S+S + A E A
Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK----SISARYAEERDRAEAEAREKETKA 1485
Query: 206 IKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNA 265
+ +E L E + +E++ LR + E L + + ++ + + A
Sbjct: 1486 LSLARALEEAL---------EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 266 IREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPS-TGELSTSSSSNDIPIA 324
+ ++ + +R ++ EL+ LQ+ + + RL + + +L T N+
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATE----DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR 1592
Query: 325 KIAERVKLSKTRSESSSSDRPV-----------LGSEISSIGVSSSVAEHLAHSLQDCSN 373
+ ++V+ + E R + L + I ++ + + L+
Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQA 1652
Query: 374 IQEIFQTLYSHGSAISESKIREFEVETERLNS-RIEHLKSQNDLLTITLEECKSNAERMS 432
+ +Q A + + + ++L S E L+ Q +L + E + +AE+
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEEL--ASSERARRHAEQER 1710
Query: 433 MLVGKYESNATALRLALQYSEQCIEA----YELLLALAESEQSLILGQFR--AAGVGSSP 486
+ +N+ + + AL ++ +EA E L +S L+ +FR V +
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770
Query: 487 GDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 546
+ + + + Q A + KA L +L+G+ F
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF------------------ 1812
Query: 547 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAA----VKLTMLELESIHIDPLSYDV 602
+T S+ + + + +EQ ++Q +RAA V+ T +L+ I + D
Sbjct: 1813 ----KATISALEAKIGQLEEQ-----LEQEAKERAAANKLVRRTEKKLKEIFMQ--VEDE 1861
Query: 603 KPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQA--Y 660
+ D + +E A M +LK QL E E++A S R+ Q +
Sbjct: 1862 RRHADQYKEQMEKA---------NARMKQLKRQLE--EAEEEATRANASRRKLQRELDDA 1910
Query: 661 LVHIEHLKSEVEEQKEQRMR----SLSSTSSGSK 690
E L EV K + R S SS+ SG +
Sbjct: 1911 TEANEGLSREVSTLKNRLRRGGPISFSSSRSGRR 1944
Score = 45.8 bits (107), Expect = 2e-04
Identities = 63/291 (21%), Positives = 127/291 (43%), Gaps = 31/291 (10%)
Query: 563 KEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQEL 622
K+ + ++D +QL + A + L+LE + + + K + L+ +N+ ++E
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQ--KLQLEKVTAE--AKIKKMEEEILLLEDQNSKFIKEK 1001
Query: 623 MAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSE--VEEQKEQRMR 680
M++ +AE +QL E+E+KA L R QE E LK E ++ E+ R
Sbjct: 1002 KLMEDRIAECSSQL--AEEEEKAKNLA-KIRNKQEVMISDLEERLKKEEKTRQELEKAKR 1058
Query: 681 SLSSTSSGSKDKPGKECADAASPALSLA----ELRTTCSE-NELAAEFTNAIRREKKLKA 735
L ++ +D+ + A L LA EL+ + ++ NA++ ++L+A
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118
Query: 736 RVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNL------VAAYEKAKKKHQNKLKK 789
++ EL E S +Q + +L+ + L AA ++ + K + ++ +
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 790 L-----------ESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 829
L E+Q+ M +RH T + L +++ + + N+ L
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL 1229
Score = 37.4 bits (85), Expect = 0.058
Identities = 61/258 (23%), Positives = 114/258 (44%), Gaps = 48/258 (18%)
Query: 602 VKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE-KEKKALELK----------- 649
VKP R + E +EL+ +KE+ +++ +L +E K ++ LE K
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 650 --------LSTREAQEQAYLVHIEH-LKSEVEEQKEQRM------RSLSSTSSGSKDKPG 694
+ R A ++ L I H L+S VEE++E+ + + + +++
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 695 KECADAASPALSL----AELRTTCSENE---LAAEFTNAIRREKKLKARVQELVSAL--- 744
+E + A L L AE + E E L + + I+ +K ++ R+ E S L
Sbjct: 961 EE--EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 745 -ERLTKSSEIRHQQSAEFVNDLK---RANSNLVAAYEKAKKKHQNKLKKLESQMMAMVER 800
E+ ++IR++Q ++DL+ + EKAK+K + L+ Q+ +
Sbjct: 1019 EEKAKNLAKIRNKQEV-MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL--- 1074
Query: 801 HETQVRMLKQRIALLEEE 818
+ Q+ LK ++A EEE
Sbjct: 1075 -QAQIDELKLQLAKKEEE 1091
Score = 36.6 bits (83), Expect = 0.098
Identities = 26/126 (20%), Positives = 62/126 (49%), Gaps = 9/126 (7%)
Query: 8 KYGNDSSAELSELHSAA-------LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQ 60
+ + A+L EL A +++L+ I +L ++L+Q +ER K + + + +
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKL 1851
Query: 61 SHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQS 120
+ + ED + R +Y+E++ + ++ + +L ++++ + R +L+ EL +
Sbjct: 1852 KEIFMQVED-ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDA 1910
Query: 121 QHEVNE 126
E NE
Sbjct: 1911 T-EANE 1915
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 79.3 bits (194), Expect = 1e-14
Identities = 179/883 (20%), Positives = 350/883 (39%), Gaps = 132/883 (14%)
Query: 11 NDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKL--------AKAQCEQSH 62
N+ + E ++ L SL ++ E+ K + E E +L+ + AK +++H
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731
Query: 63 -------LMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRS 115
+++EHE +RT +++I +L ++ E +K + Q L +
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQA-------HVENLEA 784
Query: 116 ELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSD--LNSELQRV-LTGLENV 172
++ +S+ E+ + S +D Q+ S Q+ + L+ E +R+ LT
Sbjct: 785 DIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAE 844
Query: 173 VCGRKKSSCSLSVAEVDRH-------IEQLTTASEHCDLAIKTVEEI------EGVLGRD 219
V +KK C+ E+D H ++QL + + +K++ ++ +G ++
Sbjct: 845 VEAQKKDVCT----ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Query: 220 LYPNLAEERSRWEKEL-AGLREENESLTAMLCSKEEE---LNRTKATMNAIREER-DRLR 274
+ E+ ++ G ++E E LT L +KE+ LN T +E++ ++++
Sbjct: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVK 960
Query: 275 RRVRELQTRLQ--------SVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKI 326
++ +E+Q L+ ++ ++ L+ + N E++ ++S A I
Sbjct: 961 QKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS------AGI 1014
Query: 327 AERV-KLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHG 385
++ V +L + E S V E++ V S + L ++ I EI
Sbjct: 1015 SDAVSRLETNQKEQIESLTEVHRRELND--VISIWEKKLNQQAEELQEIHEIQLQEKEQE 1072
Query: 386 SAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATAL 445
A + KI F E E +N I LK + TL E + ++ S V + T L
Sbjct: 1073 VAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKL 1132
Query: 446 RLALQYSEQCIEAYELLLALAESEQSLI----LGQFRAAGVGSSPGDQSGDENITQMLKR 501
+ L+ E ++ + L ++ L+ L + V + Q LK
Sbjct: 1133 KAHLEKLE--VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190
Query: 502 AHD-CRKTAEN-------AAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSST 553
+H+ K+ E+ ++ L ++LD C A+ ++SS S T+ S
Sbjct: 1191 SHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISS-SKTNAILSR 1249
Query: 554 ASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQR-LD 612
S C TK E L +++ + L ++ + Q L+
Sbjct: 1250 ISHCQHRTTKVKEALL--------------------IKTCTVSELEAQLRQLTEEQNTLN 1289
Query: 613 LENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVE 672
+ +L + ++ +KA + L EK+AL+ + ++ I LK E+
Sbjct: 1290 ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELS 1349
Query: 673 E-------QKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTN 725
E KE+ SS SK S +LS E + + E
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCE 1409
Query: 726 AIRREKKLKARV----QELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKK 781
+ + + L +V +E +SALE++ S +F K+A S
Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQV-------DDWSNKFSEWKKKAQSRFT-------- 1454
Query: 782 KHQNKLKKLESQM-MAMVERHE--TQVRMLKQRIALLEEENSR 821
+HQN +K+L+ Q+ + E +E Q+ +LK+ L+++N R
Sbjct: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKEE---LDQQNKR 1494
Score = 77.8 bits (190), Expect = 4e-14
Identities = 159/848 (18%), Positives = 341/848 (40%), Gaps = 110/848 (12%)
Query: 8 KYGNDSSAELSELHSAALASLKGDIVELNKRLQ---QTERERDLLEKKLAKAQCEQSHLM 64
K N E+++ +SA ++ + E N++ Q TE R L ++ + + +
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 65 REHEDVQERTTLRYEERITELHSVIA-------ELNKKIDRLQGTTIREEDEYSELRSEL 117
E +++ E E+ + EL I E+NK+I L+ ++++ +EL+ +L
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115
Query: 118 SQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK 177
Q VN S+ QD+T + + + DLN L+ EN +
Sbjct: 1116 KQKSAHVN----SLAQDETKLKAHLEKLEV---------DLNKSLK------ENTFLQEQ 1156
Query: 178 KSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAG 237
+ E R + +LT+ + D ++++ + L E++S K+L+
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL-----EDKSLEFKKLS- 1210
Query: 238 LREENESLTAMLCSKEEEL--NRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSP 295
EE + C K E L +T +N + + + R+ Q R V+
Sbjct: 1211 --EELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK- 1267
Query: 296 GRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIG 355
T T + +L+ ++ +I + +++ + + +S +D L +E ++
Sbjct: 1268 ---TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQ 1324
Query: 356 VSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAIS--ESKIREFEVETERLNSRIEHLKSQ 413
+ A + C I ++ + L + +A++ + +++E +VE L+ ++ L Q
Sbjct: 1325 KEGGNQQQAASEKESC--ITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 414 NDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLI 473
+ + E A L QY E+ E + + L+ +L
Sbjct: 1383 -----------------LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS 1425
Query: 474 LGQFRAAGVGSSPGDQSGD--ENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVA 531
+ A +Q D ++ K+A +N K L ++L+ A+
Sbjct: 1426 KEKISAL-------EQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY--- 1475
Query: 532 GCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELE 591
+ E ++ + C ++D+ +++ L+ + + ++ELE
Sbjct: 1476 ----EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531
Query: 592 SIHIDPLSYDVKPRGD-----SQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKAL 646
HI + +++ + +Q+ D+E+ L+Q+L +E E ++ E++ L
Sbjct: 1532 D-HITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL 1590
Query: 647 ELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALS 706
E ++ + +A+ + +EH+ V+ KE+ +++L +D+ E A +
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKS-KEEELKAL-------EDRLESESAAKLAELKR 1642
Query: 707 LAELRTTCSENELAAEFTNAIRREKK--------LKARVQEL---VSALERLTKSSEIRH 755
AE + + +L ++ + KK L ++QE V LE KS E
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE--S 1700
Query: 756 QQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALL 815
QS + + R+ N+ A E+ + Q ++K + +++++R+ T+ L QR+
Sbjct: 1701 SQSETLI--VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE 1758
Query: 816 EEENSRPH 823
+EE H
Sbjct: 1759 KEETVSSH 1766
Score = 66.6 bits (161), Expect = 9e-11
Identities = 185/947 (19%), Positives = 346/947 (36%), Gaps = 214/947 (22%)
Query: 72 ERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDE----YSELRSELSQSQ----HE 123
ER+ Y + +EL + L ++ +LQG + +D+ +ELR EL Q H
Sbjct: 147 ERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206
Query: 124 VNEDSRSMDQD-------QTSVSI---------------------------------PEN 143
E S+++ QT VS+ PE+
Sbjct: 207 QEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES 266
Query: 144 QSTMVTADMDNCSDLNSELQRVLTGLENVVCGRK------KSSCSLSVAEVDRHIEQLTT 197
V D + L + QRV EN++ K K C+L +E + EQL
Sbjct: 267 DGEPVVEDGTSVKTLETLQQRV-KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDE 325
Query: 198 ASEHCD------LAIKT---------------VEEIEGVLGRDLYPNLAEERSRWEKELA 236
+ + +A KT +E+ +G++ + + E E+E+A
Sbjct: 326 RLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIA 385
Query: 237 GLREENESLTA----MLCSKE-------EELNRTKATMNAIREERDRLRRRVRELQTRLQ 285
LR + +T + KE EEL + +T E R +L+ E+ +++
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLK---AEMDEQIK 442
Query: 286 SVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSS--SD 343
+++ T L + ++ SS I + +L++ E +
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 344 RPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAI---SESKIREFEVET 400
R E + + S +E+L S + + L AI SE+K+R+ + E
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 401 ERLNSRIEHL-----------KSQNDLLTITLE-ECKSNAERMSMLVGKYESNATALR-- 446
E +RI L K+Q+ L + LE E + + ++++V K+++ +L+
Sbjct: 563 ETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ 622
Query: 447 -----------LALQYS-------EQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGD 488
L QY E+C + E LL E + + +
Sbjct: 623 QDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK 682
Query: 489 QSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTS 548
Q+ E+++ L R E L + D ++ N H
Sbjct: 683 QTELESLSSELSEVLKARHKLEEELSVLKDQTD--------KMKQELEAKMDEQKNHHQQ 734
Query: 549 TTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVK-PRGD 607
S + + E+ LKD I QL+ + L+ H++ L D+K G+
Sbjct: 735 QVDSIIKEHEVSI-QRTEKALKDQINQLEL-LLKERDKHLKEHQAHVENLEADIKRSEGE 792
Query: 608 SQRLDLENAVLM-------QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQ-- 658
Q+ + V ++ A +E++A+L+ +L LE E+ L +++ EAQ++
Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852
Query: 659 -----AYLVHIEHLKSEVEEQK---EQRMRSL-----SSTSSGSKDKP------------ 693
A+ + ++ L ++E+Q EQ+++SL S G+K++
Sbjct: 853 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 912
Query: 694 -------GKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALER 746
K+ + + LS E E +F N ++ +K+K + +E+ L++
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 747 L---------------------------TKSSEIRHQQSAEFVNDLKRANSNLVAAYEKA 779
K E+ SA + + R +N E
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL 1032
Query: 780 KKKHQNKL--------KKLESQMMAMVERHETQVRMLKQRIALLEEE 818
+ H+ +L KKL Q + E HE Q++ +Q +A L+++
Sbjct: 1033 TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQK 1079
Score = 63.5 bits (153), Expect = 7e-10
Identities = 147/829 (17%), Positives = 314/829 (37%), Gaps = 97/829 (11%)
Query: 43 ERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGT 102
++E ++L +KL+ A+ + H++ E + + + + E++ + + E KK Q
Sbjct: 921 KKEIEILTQKLS-AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEA 979
Query: 103 TIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSEL 162
+++E E + L ELSQ + + N M Q S I + S + T + L
Sbjct: 980 KLKKELENTAL--ELSQKEKQFNAKMLEMAQ-ANSAGISDAVSRLETNQKEQIESLTEVH 1036
Query: 163 QRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYP 222
+R L + S+ ++++ E+L E + ++ E+ L + +
Sbjct: 1037 RRELNDV-----------ISIWEKKLNQQAEELQEIHE---IQLQEKEQEVAELKQKILL 1082
Query: 223 NLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQT 282
E+ KE+ L+EE L +E+L + A +N++ ++ +L+ + +L+
Sbjct: 1083 -FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEV 1141
Query: 283 RLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSS 342
L + N + EL + + ++++ ++K + +S S
Sbjct: 1142 DL-----------NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190
Query: 343 DRPVLGSEISSIGVS-SSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREF----E 397
+ + ++E LA L C E A+ E+K E
Sbjct: 1191 SHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE----------ALLEAKTNELINISS 1240
Query: 398 VETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIE 457
+T + SRI H + + + L + + + L ++ Q + +E
Sbjct: 1241 SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE 1300
Query: 458 AYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDEN---ITQMLKRAHDCRKTAENAAK 514
E + +++ ++ + A Q+ E ITQ+ K + +
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360
Query: 515 ALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQ 574
L K + + +VQ S+S + + SS D E++ L D +Q
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYD-----EEKCELLDQVQ 1415
Query: 575 QLK---NDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLM------------ 619
L + + K++ LE + S + K + S+ +N V
Sbjct: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFS-EWKKKAQSRFTQHQNTVKELQIQLELKSKEA 1474
Query: 620 ----QELMAMKEEM-----------AELKAQLYLLEKEKKALELKLSTREAQEQAYLVHI 664
+++ +KEE+ E++ +EK++ LE +L ++ A+ HI
Sbjct: 1475 YEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHI 1534
Query: 665 EHLKSEVEEQKE-----QRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENEL 719
E+E E + + + K + +E + + AE + EN++
Sbjct: 1535 TQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594
Query: 720 AAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEK- 778
+ ++K+L+ + S E L + +SA + +LKR +AA +K
Sbjct: 1595 YSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654
Query: 779 ----AKKKHQNKLKKLESQMMAM---VERHETQVRMLKQRIALLEEENS 820
++K + K ES + + ++ E +V +L++++ +E S
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQS 1703
Score = 53.5 bits (127), Expect = 8e-07
Identities = 147/832 (17%), Positives = 304/832 (36%), Gaps = 148/832 (17%)
Query: 32 IVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAE 91
+ EL +L+Q E++ L +A +H + E E+ + E +TE +
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISFQQA----THQLEEKENQIKSMKADIESLVTEKEA---- 1322
Query: 92 LNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTAD 151
L K+ Q +E ++L+ ELS++ + V + + + +S Q T
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT----- 1377
Query: 152 MDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEE 211
DLN +LQ ++ K+++ S + D +L + + T+ +
Sbjct: 1378 -----DLNVQLQN------SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK 1426
Query: 212 IEGVLGRDLYPNLAEERSRWEKELAGLREENES----LTAMLCSKEEELNRTKATMNAIR 267
E + + + + + S W+K+ ++++ L L K +E +N ++
Sbjct: 1427 -EKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLK 1485
Query: 268 EERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIA 327
EE D+ +R L+ G + + L T S I ++
Sbjct: 1486 EELDQQNKRFDCLK--------------GEMEDDKSKMEKKESNLETELKSQTARIMELE 1531
Query: 328 ERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA 387
+ + ES L + + + EH +Q + QE+ +
Sbjct: 1532 DHITQKTIEIES-------LNEVLKNYNQQKDI-EH-KELVQKLQHFQELGEE------- 1575
Query: 388 ISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRL 447
+++++E E + L +++ +K++ LE K E +++ V E AL
Sbjct: 1576 -KDNRVKEAEEKILTLENQVYSMKAE-------LETKKKELEHVNLSVKSKEEELKALED 1627
Query: 448 ALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRK 507
L+ SE + EL AE + + I Q ++QM ++ +K
Sbjct: 1628 RLE-SESAAKLAELKRK-AEQKIAAIKKQL-----------------LSQMEEKEEQYKK 1668
Query: 508 TAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQ 567
E+ L KL Q E S +S +T +
Sbjct: 1669 GTESHLSELNTKL---------------QEREREVHILEEKLKSVESSQSETLIVPRSAK 1713
Query: 568 RLKDYIQQLKND-RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMK 626
+ Y +Q + D + V+ T E S+ QR E L+Q + K
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISV--------------LQRNLTEKEKLLQRVGQEK 1759
Query: 627 EEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKE-------QRM 679
EE ++ +E+ +KL EA++ I HL+ E+EE+ + Q +
Sbjct: 1760 EETVSSHFEMRCQYQERL---IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV 1816
Query: 680 RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE 739
++ + + D L EL E ++ + +R+++ + ++E
Sbjct: 1817 EKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE 1876
Query: 740 LVSALERL-------------------TKSSEIRHQQSAEFVNDLKRANSNL---VAAYE 777
L S E+L T+ H + +++++ +++L +A E
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE 1936
Query: 778 KAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 829
+ K+K ++ +L+ + + + H+ ++ +LK+ EE + + L
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLEL 1988
Score = 53.1 bits (126), Expect = 1e-06
Identities = 149/826 (18%), Positives = 322/826 (38%), Gaps = 99/826 (11%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMRE-HEDVQERTTLRYE--ER 81
+ S+K DI L + ++E ++ ++ + + L +E E++ T ++ E E+
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEK 1365
Query: 82 ITELHSVIAELNKKIDRLQGTTIREEDE--YSELRSELSQSQHEVNEDSRSMDQDQTSVS 139
E+ S+ +L +LQ + E E S LR + + + E+ + + + ++S
Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS 1425
Query: 140 IPENQSTMVTADMDN-CSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTA 198
+ + D N S+ + Q T +N V + L E EQ+
Sbjct: 1426 KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV-KELQIQLELKSKEAYEKDEQINLL 1484
Query: 199 SEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNR 258
E D K + ++G + +++S+ EK+ + L E +S TA + E+ + +
Sbjct: 1485 KEELDQQNKRFDCLKG--------EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536
Query: 259 TKATMNAIREERDRLRRRV----RELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELST 314
+ ++ E ++ +EL +LQ Q G R+ I ++ +
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS 1596
Query: 315 SSSSNDIPIAKIAERVKLS-KTRSESSSSDRPVLGSEISS--IGVSSSVAEHLAHSLQDC 371
+ + K E V LS K++ E + L SE ++ + + +A +
Sbjct: 1597 MKAELETK-KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
Query: 372 SNIQEIFQTLYSHG--SAISE--SKIREFEVETERLNSRIEHLKSQNDLLTITLEECKS- 426
+ E + Y G S +SE +K++E E E L +++ ++S I K+
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
Query: 427 -------NAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQF-- 477
A+ + YE + L+ L E+ LL + + ++ + F
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK------LLQRVGQEKEETVSSHFEM 1769
Query: 478 ------RAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVA 531
R + + Q D+++ L+ + + + A ++ +G
Sbjct: 1770 RCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN------ 1823
Query: 532 GCSVQPWESLSS--NSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLE 589
++Q ++L + + T +C EQ++K+ L + ++ M E
Sbjct: 1824 --NIQAKQNLENVFDDVQKTLQEKELTCQIL-----EQKIKELDSCLVRQKEVHRVEMEE 1876
Query: 590 LESIH-----IDPLSYDVKP----RGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE 640
L S + + + KP +++ + V + L M+ + +L+ +L E
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE 1936
Query: 641 KEKKAL---------ELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKD 691
+EK+ L +L++ +E Q++ +E LK E ++++E++++ +
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQE-----LEILKKEYDQEREEKIKQEQEDLELKHN 1991
Query: 692 KPGKECADAASPALSLAE--LRTTCSEN-----ELAAEFTNAIRRE-----KKLKARVQE 739
K+ + L+ E L T E E+ AE + + E KK+ + +
Sbjct: 1992 STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD 2051
Query: 740 LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQN 785
L +R + + R ++ V DL+ L Y++ ++ +N
Sbjct: 2052 LKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097
Score = 47.0 bits (110), Expect = 7e-05
Identities = 65/315 (20%), Positives = 128/315 (40%), Gaps = 55/315 (17%)
Query: 15 AELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLM---------- 64
+++ E + + ELN +LQ+ ERE +LE+KL + QS +
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716
Query: 65 ----REHEDVQERTTLRYEERITELHSVIAELNKKIDRL---QGTTIREEDE----YSEL 113
+E D Q YEE+I+ L + E K + R+ + T+ E Y E
Sbjct: 1717 AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQER 1776
Query: 114 RSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTAD-------------MDNCSDLNS 160
+L ++ + +ED + Q + + +++ A N ++
Sbjct: 1777 LIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFD 1836
Query: 161 ELQRVLTGLENVVCG------RKKSSCSLSVAEVDR-HIEQLTTASEHCDLAIKTVEEIE 213
++Q+ L E + C ++ SC + EV R +E+LT+ E ++ ++
Sbjct: 1837 DVQKTLQEKE-LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYE-------KLQALQ 1888
Query: 214 GVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRL 273
+ GR+ L EE + EK + L + +L + E + N + + E+ +L
Sbjct: 1889 QMDGRNKPTELLEENTE-EKSKSHLVQPK-----LLSNMEAQHNDLEFKLAGAEREKQKL 1942
Query: 274 RRRVRELQTRLQSVQ 288
+ + LQ L+ ++
Sbjct: 1943 GKEIVRLQKDLRMLR 1957
Score = 40.8 bits (94), Expect = 0.005
Identities = 59/288 (20%), Positives = 114/288 (39%), Gaps = 50/288 (17%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
L++++ +L +L ERE+ L K++ + Q + L +EH+ E
Sbjct: 1918 LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE------------ 1965
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELR--SELSQSQHEVNEDSRSMDQDQTSVSIPE 142
L K+ D+ + I++E E EL+ S L Q E N +Q + ++I E
Sbjct: 1966 ------ILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ-ELEMTIKE 2018
Query: 143 NQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHC 202
+ + + E ++L +AE D +++ TA +
Sbjct: 2019 TINKAQEVEAELLESHQEETNQLLK----------------KIAEKDDDLKR--TAKRYE 2060
Query: 203 DLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENE--------SLTAMLCSKEE 254
++ EE+ + RDL L E + +++++L +EEN L L K
Sbjct: 2061 EILDAREEEMTAKV-RDLQTQLEELQKKYQQKLE--QEENPGNDNVTIMELQTQLAQKTT 2117
Query: 255 ELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTN 302
++ +K RE+ L R+++ + + + P G L T+
Sbjct: 2118 LISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTD 2165
Score = 38.5 bits (88), Expect = 0.026
Identities = 140/677 (20%), Positives = 259/677 (38%), Gaps = 125/677 (18%)
Query: 218 RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDR--LRR 275
+ L ++EE+ + ++ LA + + S T R ++ ++ E+ D R
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTP---------TRMRSRTSSFTEQLDEGTPNR 53
Query: 276 RVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKT 335
+ Q+ Q +Q PS S PI S L SSS + E +
Sbjct: 54 ESGDTQSFAQKLQLRVPSVESLFRS---PIKES---LFRSSSKESLVRTSSRESLNRLDL 107
Query: 336 RSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIRE 395
S ++S D P S AE L + D N +++ Q L ++S + +
Sbjct: 108 DSSTASFDPP---------SDMDSEAEDLVGN-SDSLNKEQLIQRLRRMERSLSSYRGKY 157
Query: 396 FEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQC 455
E+ T + E K Q I + + R++ L + + + A + + +
Sbjct: 158 SELVTAYQMLQREKKKLQG----ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDAS 213
Query: 456 IEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKA 515
+E + +++ +++ SL+ + R +G N+ +LK AE K
Sbjct: 214 LEEKDQYISVLQTQVSLLKQRLR-----------NGPMNV-DVLKPLPQLEPQAEVFTKE 261
Query: 516 LLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTS---------TTSSTASSCDTEFTKEDE 566
+ DG G SV+ E+L T S C T T E E
Sbjct: 262 ENPESDGE---PVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC-TLLTSEKE 317
Query: 567 ---QRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELM 623
++L + +Q+L+ + +L + D + + D + E M E +
Sbjct: 318 ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377
Query: 624 AMKEE-MAELKAQLYLL-----------EKEKKA----LELKLSTREAQEQAYLVHIEHL 667
MKEE +A+L++++ + EK ++A LE LST + E+A L
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR----RKL 433
Query: 668 KSEVEEQ--------KEQRM---RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSE 716
K+E++EQ +E+R+ + LS D K + + L E E
Sbjct: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE 493
Query: 717 NELAAEFTNAIRR-EKKLKARVQELVS---------------ALERLTKSSEIRHQQSAE 760
EL + R ++++K +++ S ALE L + +S
Sbjct: 494 QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESEN 553
Query: 761 FVNDLKRANSN-------LVAAYEKAKKKHQNKLKKL-----------ESQMMAMVERHE 802
+ DL++ L ++ EK+ ++++N+ K L ++ MVE+H+
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK 613
Query: 803 TQVRMLK-QRIALLEEE 818
T++ LK Q+ AL E+
Sbjct: 614 TELESLKHQQDALWTEK 630
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 78.6 bits (192), Expect = 2e-14
Identities = 170/894 (19%), Positives = 344/894 (38%), Gaps = 133/894 (14%)
Query: 44 RERDLL-EKKLAKAQCEQSHLMRE----HEDVQERTTL--RYEERITELHSVIAELNKKI 96
RE+ L E +L + + QS LM E E +Q T L EE L + EL +
Sbjct: 858 REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEIC 917
Query: 97 DRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCS 156
L+ EE+ L++E + Q + E +++++++ + + A +
Sbjct: 918 HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977
Query: 157 -------DLNSELQRVLTGLENVVCG-----RKKSSCSLSVAEV-DRHIEQLTTASEHCD 203
D N +L + LE+ + ++ S S+A++ ++H +T E
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLR 1037
Query: 204 LAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATM 263
K +E+E + L + + ++A L+ + L L KEEEL A +
Sbjct: 1038 REEKQRQELEKTRRK-----LEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARV 1092
Query: 264 NAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPI 323
+++ +++REL++++ +Q S + EL + + +
Sbjct: 1093 EEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTL 1152
Query: 324 AKIAERVKLSKTRSESSSSDRPVLGSEISSIGVS--------SSVAEHLAHSLQDC---- 371
A + +L R + + + L E + S E LA L+
Sbjct: 1153 DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK 1212
Query: 372 SNIQEIFQTLYS-------------HGSAISESKIREFEVETERLNSRIEHLKSQNDLLT 418
+N+++ QTL + G SE K ++ E + + L + + L
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA 1272
Query: 419 ITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLIL---- 474
+ + + + ++ L+ + +S ++ L E ++ + LL E+ Q L L
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ-EENRQKLSLSTKL 1331
Query: 475 -------GQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENA------AKALLMKLD 521
FR + ++ I + + D +K E++ A+ + KL
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 522 GSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKED----EQRLKDYIQQL- 576
G V ++ L D + ++ E++ K + Q L
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 577 -----------KNDRAAVKLTMLELESIHI-DPLSYDVKPRGDSQRLDLENAVLMQELMA 624
+ DRA + E +++ + L ++ + + +RL+ + M++LM+
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511
Query: 625 MKEEMAELKAQLYLLEKEKKAL-----ELKLSTREAQEQAYLVHIEHLKSEV-------- 671
K+++ + ++ LEK K+AL E+K E +++ L+ EV
Sbjct: 1512 SKDDVGK---SVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568
Query: 672 ------------EEQKEQRMRSLSSTSSGSKD-KPGKECADAASPALSLAELRTTCSENE 718
EE+K+Q +R + + +D + + A AA L + +
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDS 1628
Query: 719 LAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLV----- 773
AI++ +KL+A++++ + L+ S E Q+ E LK + ++
Sbjct: 1629 ANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE 1688
Query: 774 -AAYEKAKKKHQNKLKKLESQM--------MAMVERHETQVRMLKQRIALLEEE 818
AA E+AK++ Q + +L ++ +A+ E+ R L+ RIA LEEE
Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGALALEEK-----RRLEARIAQLEEE 1737
Score = 71.2 bits (173), Expect = 4e-12
Identities = 164/849 (19%), Positives = 323/849 (38%), Gaps = 102/849 (12%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+ L+ I EL + L+ R+ EK+ E L E ED + T + E R ++
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR-SK 1164
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
+ L K ++ T E + E+R + SQ+ E+ E Q + + + N
Sbjct: 1165 REQEVNILKKTLEEEAKT---HEAQIQEMRQKHSQAVEELAE------QLEQTKRVKANL 1215
Query: 145 STMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDL 204
+ +L +E++ +L G + RKK L +V + E +E D
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV-KFNEGERVRTELADK 1274
Query: 205 AIKTVEEIEGVLG-----RDLYPNLAEERSRWEKELAG----LREENE---SLTAMLCSK 252
K E++ V G L ++ S E +L L+EEN SL+ L
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV 1334
Query: 253 EEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGEL 312
E+E N + + E + L +++ L ++ ++ S G L + +L
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL 1394
Query: 313 STSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCS 372
S ++ K+A KL KT++ L E+ + V +H S +
Sbjct: 1395 EGLSQRHE---EKVAAYDKLEKTKTR--------LQQELDDLLVD---LDHQRQSACNLE 1440
Query: 373 NIQEIFQTLYSHGSAIS----------ESKIREFEVETERLNSRIEHLKSQ-------ND 415
Q+ F L + IS E++ RE E + L +E Q N
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNK 1500
Query: 416 LLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ---SL 472
+E+ S+ + + V + E + AL ++ + +E E L E + +
Sbjct: 1501 QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV 1560
Query: 473 ILGQFRAAGVGSSPG-DQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVA 531
L +A G D+ +E Q++++ + E+ K M AVA
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM----------AVA 1610
Query: 532 GCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELE 591
+ +H + + + I+QL+ +A +K M EL+
Sbjct: 1611 ARKKLEMDLKDLEAHIDSANKNRD---------------EAIKQLRKLQAQMKDCMRELD 1655
Query: 592 SIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLS 651
+ + + ++L A E++ ++EE+A + ++E+ L +++
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEA----EMIQLQEELAAAERAKRQAQQERDELADEIA 1711
Query: 652 TREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTS-SGSKDKPGKECADAASPALSLAEL 710
+ L L++ + + +E+ +T + K D + L+L
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE-- 1769
Query: 711 RTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSS----EIRHQQSAEFVNDLK 766
R+ +NE A + R+ K+LK ++QE+ ++ K+S E + Q E +++
Sbjct: 1770 RSHAQKNENARQ--QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET 1827
Query: 767 RANSNLVAAYEKAKKKHQNKLKKLE------SQMMAMVERHETQVRMLKQRIALLEEENS 820
+ + +KK ++ L +++ Q ++ T+++ LK+++ EEE
Sbjct: 1828 KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ 1887
Query: 821 RPHTNETSL 829
R + + L
Sbjct: 1888 RANASRRKL 1896
Score = 67.4 bits (163), Expect = 5e-11
Identities = 159/822 (19%), Positives = 307/822 (37%), Gaps = 129/822 (15%)
Query: 16 ELSELHSAALASLKGDIVE-------LNKRLQQTERERDLLE---KKLAKAQCEQSHLMR 65
E+ + HS A+ L + + L K Q E ER L K L + + + H +
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 66 EHEDVQERTTLRYEE--RI-TELHSVIAELNKKIDRLQGTTIREED-------EYSELRS 115
+ E + +++ E R+ TEL + +L ++D + G + + ++S L S
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 116 ELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCG 175
+L +Q + E++R T + E++ ++ + L++ + L V
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 176 RKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRD-----LYPNLAEERSR 230
KK +++ + L TA E + K +++EG+ R Y L + ++R
Sbjct: 1369 MKK--------KMEDSVGCLETAEE---VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 231 WEKELAGLREENESLTAMLCSKEEE-------LNRTKATMNAIREERDRLRRRVRELQTR 283
++EL L + + C+ E++ L K EERDR RE +T+
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK 1477
Query: 284 LQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSD 343
S+ + + R E+ SS D + K ++ SK E +
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKD-DVGKSVHELEKSKRALEQQVEE 1536
Query: 344 RPVLGSEISS-IGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETER 402
E+ + + L +LQ ++ F+ SE K ++ +
Sbjct: 1537 MKTQLEELEDELQATEDAKLRLEVNLQA---MKAQFERDLQGRDEQSEEKKKQLVRQVRE 1593
Query: 403 LNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATA----LRLALQYSEQCIEA 458
+ + +E + Q + ++ + + + + + N LR + C+
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR- 1652
Query: 459 YELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLM 518
EL A E+ L + + S + + + L A ++ A+ L
Sbjct: 1653 -ELDDTRASREEILAQAKENEKKLKSMEAEMI---QLQEELAAAERAKRQAQQERDELAD 1708
Query: 519 KLDGSCG-GAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLK 577
++ S G GA A+ A E E+EQ + I
Sbjct: 1709 EIANSSGKGALALE----------------EKRRLEARIAQLEEELEEEQGNTELI---- 1748
Query: 578 NDRAAVKLTMLELESIHID---PLSYDVKPRGDSQRLDLENAVLMQELM----------- 623
NDR +K L+++ I+ D S+ K Q+L+ +N L +L
Sbjct: 1749 NDR--LKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Query: 624 ----AMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRM 679
A++ ++A+L+ QL KE++A ++ E + + L+ ++ + E+ K+Q
Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ-- 1864
Query: 680 RSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQE 739
AD AS L +L+ E E A+ NA RR +
Sbjct: 1865 ------------------ADKASTRLK--QLKRQLEEAEEEAQRANASRR---------K 1895
Query: 740 LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKK 781
L LE T++++ +++ + N L+R + V A+K
Sbjct: 1896 LQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARK 1937
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 78.6 bits (192), Expect = 2e-14
Identities = 165/830 (19%), Positives = 318/830 (38%), Gaps = 83/830 (10%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQ---SHLMREHEDVQERTTLR---- 77
+A LK ++V++ + ER+ +KL K +C++ + E Q R+ L
Sbjct: 223 VAVLKKELVQVQTLMDNMTLERERESEKL-KDECKKLQSQYASSEATISQLRSELAKGPQ 281
Query: 78 ----YEERITELHSVIAELNKKIDRLQGTTIREEDEYSELR---SELSQSQHEVNEDSRS 130
Y + + +L S + EL +K L +++E +Y++L +E S S+ +
Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ 341
Query: 131 MDQD----QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVA 186
D D Q+ +S E + ++ + +L+ L+ +E K L
Sbjct: 342 KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ 401
Query: 187 EVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLT 246
++ L SE L K +E E LG + + L E+R ++L ++ L
Sbjct: 402 REEKEQHGLQLQSEINQLHSKLLET-ERQLG-EAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 247 AMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPIN 306
L EE+L ++ + D+ +++ +E Q QS A + L R I
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI- 518
Query: 307 PSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAH 366
D I + ++ SK +R L ++I + ++V L
Sbjct: 519 ----------GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL-- 566
Query: 367 SLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKS 426
QE TL + + TE+L ++ E K + L ++E K+
Sbjct: 567 --------QEKNHTLQEQVTQL-----------TEKLKNQSESHKQAQENLHDQVQEQKA 607
Query: 427 NAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSP 486
+ V E++ L L S++ + ++ + A++E L + A
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK-AKTELLLSAEAAKTAQRADLQ 666
Query: 487 GDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 546
+N Q ++ + T + A L C + + + SL +
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726
Query: 547 TSTTSSTASSCDT-EFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPR 605
D+ E EQ L+D QQ + + T LEL + + K
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN------TDLELRATELSKQLEMEKEI 780
Query: 606 GDSQRLDLEN-----AVLMQELMAMKEEMAELKAQLYLLEKEKK----ALELKLSTREAQ 656
S RLDL+ + Q+L +EE LK L +E K L ++ T +
Sbjct: 781 VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840
Query: 657 EQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSE 716
Q + E L +E+ K+ ++ +S + SK + KE + ++ +L TC E
Sbjct: 841 LQKVKMEKEALMTELSTVKD-KLSKVSDSLKNSKSEFEKENQKGKA---AILDLEKTCKE 896
Query: 717 --NELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLK---RANSN 771
++L + N ++ +K+LK +++ A +L +Q + N LK +
Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 772 LVAAYEKAKKKHQNKLKKLESQM----MAMVERHETQVRMLKQRIALLEE 817
L + K+ + K K++E+ +A++++ E + ++ +Q +E
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE 1006
Score = 77.4 bits (189), Expect = 5e-14
Identities = 166/863 (19%), Positives = 325/863 (37%), Gaps = 146/863 (16%)
Query: 37 KRLQQTERERDLLEKKL-AKAQCEQSHLMREHEDVQER--TTLRYEERITELHSVIAELN 93
K +Q T ++DL ++L ++ ++ L R H ++ E+ T + +E ++E+ + L
Sbjct: 333 KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 94 KKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMD 153
+ +LQ +E +L+SE++Q ++ E R + + + S+ D +
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE 452
Query: 154 N-CSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEI 212
+DL +L R+ L+ V + L + +Q S L + ++
Sbjct: 453 QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR-EAQNDL 511
Query: 213 EGVLGR-----DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIR 267
E VL + NL + ++ ++ L +E E L A + + E E A +N ++
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET----AVLNQLQ 567
Query: 268 EERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGE-----LSTSSSSNDIP 322
E+ L+ +V +L +L++ + + L + LS +S N++
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
Query: 323 IAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHL---AHSLQD--------- 370
+ K+S+ + + +L +E + + + HL ++LQD
Sbjct: 628 SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 687
Query: 371 --CSNIQEIFQTLYSHGSAISESKIREF-------EVETERLNSRIEHLKSQNDLLTITL 421
+ Q H S + ES ++E+ E +TE L +I+ L++ + + +
Sbjct: 688 TQLDQVTAKLQDKQEHCSQL-ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746
Query: 422 EECKSNAERMSMLVGKYESNATAL--------------RLALQYSEQCIEAYELLLALAE 467
E+ + ++ L E AT L RL LQ + +E+ + L E
Sbjct: 747 EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806
Query: 468 SEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGA 527
E+ ++ F E ++Q K H+ L K+
Sbjct: 807 EEKQILKQDF---------------ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851
Query: 528 FAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTM 587
E + S S + + +EF KE+++ K +
Sbjct: 852 MT---------ELSTVKDKLSKVSDSLKNSKSEFEKENQKG---------------KAAI 887
Query: 588 LELESIHIDPLSYDVKPRGDSQRLDLENAV-----LMQELMAMKEEMAELKAQLYLLEKE 642
L+LE K ++ +EN + L + L KE +LK +L ++++
Sbjct: 888 LDLEKT--------CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
Query: 643 KKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAAS 702
+ L E +EQ +I LK E++K+Q +A
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ--------------------IEALQ 979
Query: 703 PALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFV 762
L +A L+ T EN+L + T A + K ++ L + E KS E Q ++F
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE---KSQETFKQLQSDFY 1036
Query: 763 ----------NDLKRANSNLVAAYE-----KAKKKHQNKL-KKLESQMMAMVERHETQVR 806
DLK L A E + + +QNKL ++L++ + + + +
Sbjct: 1037 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQ 1096
Query: 807 MLKQRIALLEEENSRPHTNETSL 829
L++R L++ E L
Sbjct: 1097 QLQERCKALQDIQKEKSLKEKEL 1119
Score = 62.8 bits (151), Expect = 1e-09
Identities = 153/851 (17%), Positives = 329/851 (38%), Gaps = 105/851 (12%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQS---HLMREHEDVQERTTLRYEER 81
+ +L+ + + + + E+ER+ L K+ + E + L ++ +QE+ T E+
Sbjct: 525 IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
Query: 82 ITE----------LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSM 131
+ LH + E + Q + E +EL S+L++S+ +V++ +
Sbjct: 585 KNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644
Query: 132 DQDQTSVSIPENQSTMVTADMDN--------CSDLNSELQRVLTGLENVVCGR--KKSSC 181
+ E T AD+ N D EL ++ T L+ V K+ C
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC 704
Query: 182 SLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREE 241
S +++ H+++ ++ L KT EE+EG + + L + E ++ E+ L L+++
Sbjct: 705 S----QLESHLKEYK--EKYLSLEQKT-EELEGQI-KKLEADSLEVKASKEQALQDLQQQ 756
Query: 242 NESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTST 301
+ T + EL T+ + + E++ + +LQ + ++++ S +LT
Sbjct: 757 RQLNTDL------ELRATELSKQ-LEMEKEIVSSTRLDLQKKSEALE----SIKQKLTKQ 805
Query: 302 NRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVA 361
+ T S I ++ R++ + T + ++ L +E+S+ V
Sbjct: 806 EEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST------VK 859
Query: 362 EHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITL 421
+ L+ N + F+ G A + + +L ++E+ + L +L
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 422 EECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQS---------L 472
E+ K + ++ + + + + L+ +E+ E +L + E +QS
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK--EEQQLQGNINELKQSSEQKKKQIEA 977
Query: 473 ILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAG 532
+ G+ + A + + + + +TQ + AE ++L F
Sbjct: 978 LQGELKIAVLQKTELENKLQQQLTQAAQEL-----AAEKEKISVLQNNYEKSQETFKQLQ 1032
Query: 533 CSVQPWES--LSSNSHTSTTSSTASSCDTEFTKEDEQ--RLKDYIQQLKNDRAAVKLTML 588
ES L++ + S + Q IQ+LK +A ++
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 589 ELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALEL 648
+ E L K D Q+ E ++ +EL+ K ++AE++ EKE L
Sbjct: 1093 KKEQ----QLQERCKALQDIQK---EKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145
Query: 649 KLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLA 708
+L + + + + +++ K + +QK + S + + + + +
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ---------QIL 1196
Query: 709 ELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRA 768
+ + E EL EF I +E KL + ++E +++ + A+ +
Sbjct: 1197 KDQVKKEEEELKKEF---IEKEAKLHSEIKEKEVGMKK-------HEENEAKLTMQITAL 1246
Query: 769 NSNLVAAYEKAKKKHQNKLKKLESQ----------MMAMVERHETQVRMLKQRIALLEEE 818
N NL +K + Q ++ +LE Q + A V+ ++ + R L +R E E
Sbjct: 1247 NENL-GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE 1305
Query: 819 NSRPHTNETSL 829
+ T L
Sbjct: 1306 IEKLQTKVLEL 1316
Score = 46.6 bits (109), Expect = 9e-05
Identities = 55/268 (20%), Positives = 114/268 (42%), Gaps = 34/268 (12%)
Query: 563 KEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQEL 622
+ + ++LKD ++L++ A+ + T+ +L R + + E AV +QEL
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQL--------------RSELAKGPQEVAVYVQEL 290
Query: 623 MAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSL 682
+K + EL + L + E + E + V +++++ + QK+ + L
Sbjct: 291 QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH-QKDLDCQQL 349
Query: 683 SSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRRE-KKLKARVQELV 741
S S S+ SL + SE E T ++ E +++ + Q L
Sbjct: 350 QSRLSASET--------------SLHRIHVELSEK---GEATQKLKEELSEVETKYQHLK 392
Query: 742 SALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERH 801
+ ++L + E + Q + +++ + +S L+ + + H +LK+ +
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH-GRLKEQRQLSSEKLMDK 451
Query: 802 ETQVRMLKQRIALLEEENSRPHTNETSL 829
E QV L+ +++ LEE+ TN T L
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTEL 479
Score = 43.9 bits (102), Expect = 6e-04
Identities = 60/308 (19%), Positives = 134/308 (43%), Gaps = 49/308 (15%)
Query: 23 AALASLKGDIVELNKRLQ----QTERERDLLEKKLAKAQCEQSHLMR------EHEDVQE 72
AA+ L+ EL +LQ T +E+ L+K L K + E SH ++ + + +Q
Sbjct: 885 AAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK-EASHQLKLELNSMQEQLIQA 943
Query: 73 RTTLRYEER--------ITELHSVIAELNKKIDRLQG----TTIREEDEYSELRSELSQS 120
+ TL+ E+ I EL + K+I+ LQG +++ + ++L+ +L+Q+
Sbjct: 944 QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
Query: 121 QHEVNEDSRSMDQDQTSVSIPENQSTMVTAD--------MDNCSDLNSELQRVLTGLENV 172
E+ + + Q + + + +D + DL S +++ E++
Sbjct: 1004 AQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063
Query: 173 VCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWE 232
+ R + + ++ I++L TA + E+ + L ++ +E+S E
Sbjct: 1064 ISNRNQ------IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ-DIQKEKSLKE 1116
Query: 233 KELAGLREENESLTAMLCSKEEELNRTKATMNA-----------IREERDRLRRRVRELQ 281
KEL + + + + C +E+E+ + + + +++ + L ++ ELQ
Sbjct: 1117 KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQ 1176
Query: 282 TRLQSVQA 289
+ S++A
Sbjct: 1177 GKADSLKA 1184
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 76.6 bits (187), Expect = 9e-14
Identities = 166/814 (20%), Positives = 320/814 (39%), Gaps = 77/814 (9%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+A LK + +L K L+++E +R+ L+ K E++ L+ + + QE T EE+
Sbjct: 861 VAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQE-TLANVEEQCEW 919
Query: 85 LHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQ 144
L +L ++ L EE+ SEL + + + E E + +D +T + E +
Sbjct: 920 LIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKE 979
Query: 145 STMVTADMDNCSD----LNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASE 200
+ N ++ LN ++ ++ + V +++ L + E E+L++ S+
Sbjct: 980 KRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEE-----EKLSSLSK 1034
Query: 201 HCDLAIKTVEEIEGVL--GRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNR 258
+ V+E+EG L R N E + E L RE E+L + EEL +
Sbjct: 1035 ANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRK 1094
Query: 259 TKATMNAIREERD-------RLRRRVRELQTRL----------QSVQATGPSSPGRLTST 301
+ ++ + + + +L++ V+ELQT++ ++ +A LT
Sbjct: 1095 KELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQD 1154
Query: 302 NRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVA 361
+N E+ SS + + I K E +K + + L E +S + A
Sbjct: 1155 LADLNERLEEVGGSSLA-QLEITKKQE----TKFQKLHRDMEEATLHFETTSASLKKRHA 1209
Query: 362 EHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL----KSQNDLL 417
+ LA N+Q++ Q L E + ++E + L +R+E + + L
Sbjct: 1210 DSLAELEGQVENLQQVKQKL--------EKDKSDLQLEVDDLLTRVEQMTRAKANAEKLC 1261
Query: 418 TI---TLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLIL 474
T+ L E + ++++ L + T L + +E E L+ E+S
Sbjct: 1262 TLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFT 1321
Query: 475 GQFRAAGVGSSPGDQSGDENITQMLKRA-HDCRKTAENAAKALLMKLDGSCGGAFAVAGC 533
Q G + + L++A DC E + +K + +
Sbjct: 1322 RQIEDLR-GQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAE--LHRTLSKVNA 1378
Query: 534 SVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQL--KNDR-AAVKLTMLEL 590
+ W N+ T + KE RL++ + + N R A+++ +L
Sbjct: 1379 EMVQWRMKYENNVIQRTEDLEDA-----KKELAIRLQEAAEAMGVANARNASLERARHQL 1433
Query: 591 ESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKL 650
+ D LS K R + RLD + + L K++ E +A L +KE +AL +L
Sbjct: 1434 QLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTEL 1493
Query: 651 STREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL 710
+ + +V E L+ E + +E+ + G+K+ E E+
Sbjct: 1494 LKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEE-EKTEV 1552
Query: 711 RTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANS 770
+ T E E A E R E K+ EL+ A L + + ++ F +
Sbjct: 1553 QVTLEETEGALE-----RNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTID 1607
Query: 771 NLVAAYE----------KAKKKHQNKLKKLESQM 794
+L ++ + + KKK + L ++E Q+
Sbjct: 1608 SLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQL 1641
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/314 (20%), Positives = 127/314 (40%), Gaps = 71/314 (22%)
Query: 25 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITE 84
+++L + E K L + E+ + L+E++ + Q + E E ER + E
Sbjct: 1521 ISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVT----LEETEGALERNESKILHFQLE 1576
Query: 85 LHSVIAELNKK------------------IDRLQGTTIRE--------------EDEYSE 112
L AEL +K ID LQ + E E++ +E
Sbjct: 1577 LLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNE 1636
Query: 113 LRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENV 172
+ +LS + +V+E ++S+ Q Q + + Q +D+ + LNS+L+ E V
Sbjct: 1637 MELQLSCANRQVSEATKSLGQLQIQIKDLQMQ-------LDDSTQLNSDLK------EQV 1683
Query: 173 VCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLY----PNLAEER 228
+++S S E R +++ T + E +E +L+ +L ++
Sbjct: 1684 AVAERRNSLLQSELEDLRSLQEQTERGRR----LSEEELLEATERINLFYTQNTSLLSQK 1739
Query: 229 SRWEKELAGLREENESLTAMLCSKEE--------------ELNRTKATMNAIREERDRLR 274
+ E ++A +++E E + + EE EL + + T+ + R+ +
Sbjct: 1740 KKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENME 1799
Query: 275 RRVRELQTRLQSVQ 288
+ + +LQ RL +
Sbjct: 1800 QTITDLQKRLAEAE 1813
Score = 37.7 bits (86), Expect = 0.044
Identities = 57/259 (22%), Positives = 110/259 (42%), Gaps = 42/259 (16%)
Query: 598 LSYDVKPRGDSQRLDLENAVLMQELMAMKEEMA-------ELKAQLYLLEKEKKALELKL 650
L + +KP S + E A L +E +++ + ELKA+ L +EK L L+L
Sbjct: 844 LFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQL 903
Query: 651 STREAQEQAYLVHIEH-----LKSEVEEQKEQRMRSLSSTSSGSKD----------KPGK 695
EQ L ++E +KS++ Q E R++ LS ++ K
Sbjct: 904 QA----EQETLANVEEQCEWLIKSKI--QLEARVKELSERVEEEEEINSELTARGRKLED 957
Query: 696 ECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRH 755
EC + + +L T ++E T + K L V+ L + +L +++++
Sbjct: 958 ECFELKK---EIDDLETMLVKSEKEKRTTE--HKVKNLTEEVEFLNEDISKLNRAAKVVQ 1012
Query: 756 QQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLE--------SQMMAMVERHETQVRM 807
+ + ++DL L ++ KA K + ++ +LE ++M E H+ + +
Sbjct: 1013 EAHQQTLDDLHMEEEKL-SSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNL 1071
Query: 808 LKQRIALLEEENSRPHTNE 826
R ++ E+S+ H E
Sbjct: 1072 KLNRESMENLESSQRHLAE 1090
Score = 33.5 bits (75), Expect = 0.83
Identities = 27/130 (20%), Positives = 59/130 (45%), Gaps = 5/130 (3%)
Query: 12 DSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQ 71
D L+E AL + I +L R+++ E E LE ++ ++ Q R ++
Sbjct: 1804 DLQKRLAEAEQMALMGSRKQIQKLESRVRELEGE---LEGEIRRSAEAQRGARRLERCIK 1860
Query: 72 ERTTLRYEER--ITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSR 129
E T E++ ++ + + + +L K+ + E + ++ S+ + QHE+NE
Sbjct: 1861 ELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKE 1920
Query: 130 SMDQDQTSVS 139
+ ++ V+
Sbjct: 1921 RAEVAESQVN 1930
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 76.3 bits (186), Expect = 1e-13
Identities = 163/849 (19%), Positives = 326/849 (38%), Gaps = 146/849 (17%)
Query: 34 ELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELN 93
+L ++ ++ R ++LLE++ +AQ L + + LR+ L + + EL
Sbjct: 395 QLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRH-----GLETQVMELQ 449
Query: 94 KKIDRLQG------TTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTM 147
K+ +QG +++ E EL E+ + + V E R +++ T++ +
Sbjct: 450 NKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEE-- 507
Query: 148 VTADMDNCSDLNSELQRVLTGL---------ENVVCGRKKSSCSLSVAEVDRHIEQLTTA 198
V + + + QR L ++ V ++ S V + R +E+ +
Sbjct: 508 VASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEE 567
Query: 199 SEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSK----EE 254
+ H + ++ E+ ++EL LR E E + L K +
Sbjct: 568 TGH---------------WQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQR 612
Query: 255 ELNRTKAT------MNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPS 308
EL + +A+ + +++E R + ++ELQ QS + G L +
Sbjct: 613 ELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672
Query: 309 TGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSL 368
+ ++ + K ++++ E +S + V +E + +G + E
Sbjct: 673 -ADRGRELEEQNLQLQKTLQQLRQD---CEEASKAKMVAEAEATVLGQRRAAVETTLRET 728
Query: 369 QDCSN---------IQEIFQT--LYSHGSAIS---ESKIREFEVETERLNSRIEHLKSQN 414
Q+ ++ Q++ +T L G A+ K++ E E ++L + + +
Sbjct: 729 QEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEE 788
Query: 415 DLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLIL 474
L ++ E + + L AL+ + E A E ++ L+
Sbjct: 789 GSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLL- 847
Query: 475 GQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCS 534
D++ D + + L++ + K A +A L A A
Sbjct: 848 -------------DRTVD-RLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQ 893
Query: 535 VQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIH 594
+ W S + E T RL+D IQ+L R A++ + E ++
Sbjct: 894 AKDWAS-----------------EAEKTSGGLSRLQDEIQRL---RQALQASQAERDTAR 933
Query: 595 IDPLSYDVKPRGDSQRLDLENAVLMQ-----ELMAMKEEMAELKAQLYLLEKEKKALEL- 648
+D + +G Q + EN Q +L ++E+++ L+ + L++EK +EL
Sbjct: 934 LDKELLAQRLQGLEQ--EAENKKRSQDDRARQLKGLEEKVSRLETE---LDEEKNTVELL 988
Query: 649 ------------KLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKE 696
+L T QE++ +E K +E Q + L+S+ K
Sbjct: 989 TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQK------ 1042
Query: 697 CADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQ 756
P+ SL++L S+N+L E A REK + +Q LER K I+ +
Sbjct: 1043 ------PSASLSQLE---SQNQLLQERLQAEEREKTV---LQSTNRKLERKVKELSIQIE 1090
Query: 757 QSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLE----SQMMAMVERHETQVRMLKQRI 812
+ VND K S V A ++ + + ++++L+ + E+HE L+ RI
Sbjct: 1091 DERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVN-EQLQARI 1149
Query: 813 ALLEEENSR 821
LE+++ R
Sbjct: 1150 KSLEKDSWR 1158
Score = 55.5 bits (132), Expect = 2e-07
Identities = 145/741 (19%), Positives = 283/741 (38%), Gaps = 94/741 (12%)
Query: 110 YSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGL 169
Y LR S+S+ V + + + + + ST A + ELQR L
Sbjct: 319 YGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLD-- 376
Query: 170 ENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERS 229
E V +K+ S ++R +E+ T E C + +E +G A++ +
Sbjct: 377 EEV---KKRQKLEPSQVGLERQLEEKT---EECSRLQELLERRKGE---------AQQSN 421
Query: 230 RWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQA 289
+ + + L ++ E L L ++ EL + ++ L + + E + L+ V
Sbjct: 422 KELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLE 481
Query: 290 TGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLS----KTRSESSSSDRP 345
+L R + G L +S D + + ++ + + + ++ D
Sbjct: 482 GKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHA 541
Query: 346 VLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSA---ISESKIREFEVETER 402
VL +E + S++ L L++ S +Q+++ ++ ++ + +E E
Sbjct: 542 VLEAERQKM---SALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEE 598
Query: 403 LNSRIEHLKSQNDLLTITLEECKSNA-ERMSMLVGKYESNATALRLALQYSEQCIEAYEL 461
+ E L + ++L LE+ +++A + + V K E T L +E+ ++ E+
Sbjct: 599 ME---EELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAER--QSQEV 653
Query: 462 LLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLD 521
+ E L R V + G + ++N+ Q+ K R+ E A+KA +
Sbjct: 654 AGRHRDRELEKQLAVLR---VEADRGRELEEQNL-QLQKTLQQLRQDCEEASKAKM---- 705
Query: 522 GSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRA 581
V E+ + +T E E +R+ QQLK R
Sbjct: 706 -------------VAEAEATVLGQRRAAVETTLRETQEE-NDEFRRRILGLEQQLKETRG 751
Query: 582 AVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEK 641
V + + + R QRL+ E L + L A +EE L A LE
Sbjct: 752 LVD-----------GGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEA 800
Query: 642 EKKALELKLSTREAQEQAYLVH-----------IEHLKSEVEEQKEQRMRSLSSTSSGSK 690
+ + L+ R QEQ L + K+E+EEQK R++
Sbjct: 801 RLEEAQRGLA-RLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRL----- 854
Query: 691 DKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKS 750
+K ++ + + AL + + + + E +A R+ K + ++ L RL
Sbjct: 855 NKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE 914
Query: 751 SEIRHQ--QSAEFVNDLKRANSNLVA--------AYEKAKKKHQNKLKKLESQMMAMVER 800
+ Q Q+++ D R + L+A E K+ ++ ++L+ + V R
Sbjct: 915 IQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG-LEEKVSR 973
Query: 801 HETQVRMLKQRIALLEEENSR 821
ET++ K + LL + +R
Sbjct: 974 LETELDEEKNTVELLTDRVNR 994
Score = 53.5 bits (127), Expect = 8e-07
Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 37/292 (12%)
Query: 6 AMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTERERD-------LLEKKLAKAQC 58
A + D ++E +E S L+ L+ +I L + LQ ++ ERD LL ++L +
Sbjct: 890 AQRQAKDWASE-AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQ 948
Query: 59 EQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELS 118
E + R +D + R EE+++ L + + E ++ L R D+ +LR+EL
Sbjct: 949 EAENKKRSQDD-RARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELM 1007
Query: 119 QSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKK 178
Q RS QD + D + N +L+ L E G +K
Sbjct: 1008 Q--------ERSARQD-------------LECDKISLERQNKDLKTRLASSE----GFQK 1042
Query: 179 SSCSLSVAEVDRHIEQLTTASEHCDLAI--KTVEEIEGVLGRDLYPNLAEERSRWEKELA 236
S SLS E + Q +E + + T ++E + ++L + +ER +
Sbjct: 1043 PSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKV-KELSIQIEDERQHVNDQKD 1101
Query: 237 GLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQ 288
L ++L + EEE+ R + E + +LQ R++S++
Sbjct: 1102 QLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLE 1153
Score = 50.4 bits (119), Expect = 7e-06
Identities = 132/682 (19%), Positives = 248/682 (36%), Gaps = 121/682 (17%)
Query: 31 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERT---TLRYEERITELHS 87
D +L + +Q ++ +LE + K L RE E+ E T +++ +L +
Sbjct: 525 DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRA 584
Query: 88 VIAELNKKIDRLQGTTIREE--DEYSELRSELSQS--------QHEVNEDSRSMDQDQTS 137
EL + R++ + EE ++ L+ EL Q+ Q EV + Q++
Sbjct: 585 TKQELLQL--RMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK 642
Query: 138 VSIPENQSTMVTADMDNCSDLNSELQRVLTGLE-NVVCGRKKSSCSLSVAEVDRHIEQLT 196
E QS V + EL++ L L GR+ +L ++ + ++QL
Sbjct: 643 ELQAERQSQEVAG-----RHRDRELEKQLAVLRVEADRGRELEEQNL---QLQKTLQQLR 694
Query: 197 TASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEEL 256
E A K V E E + L + R+ E L +EEN+ + E++L
Sbjct: 695 QDCEEASKA-KMVAEAEATV-------LGQRRAAVETTLRETQEENDEFRRRILGLEQQL 746
Query: 257 NRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSS 316
T+ ++ RLR +++ L+ Q ++ +N S E +
Sbjct: 747 KETRGLVDGGEAVEARLRDKLQRLEAEKQQLE--------------EALNASQEEEGS-- 790
Query: 317 SSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQE 376
+A + + R E + LG E + L +L++ +E
Sbjct: 791 ---------LAAAKRALEARLEEAQRGLARLGQE----------QQTLNRALEEEGKQRE 831
Query: 377 IFQTLYSHGSAISESKIREFEVETERLNSRIEHL----KSQNDLLTITLEECKSNAERMS 432
+ + G A E + R + +RLN +E + K L LE+ K A R
Sbjct: 832 VLR----RGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR-- 885
Query: 433 MLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGD 492
A A R A ++ + + L L + Q L R A S +
Sbjct: 886 -------EVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL-----RQALQASQAERDTAR 933
Query: 493 ENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSS 552
+ + +R + AEN ++ + + L T
Sbjct: 934 LDKELLAQRLQGLEQEAENKKRS---------------QDDRARQLKGLEEKVSRLETEL 978
Query: 553 TASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTM--LELESIHIDPLSYDV-------- 602
E + R +D + QL+ + + LE + I ++ + D+
Sbjct: 979 DEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE 1038
Query: 603 ---KPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREA---- 655
KP +L+ +N +L + L A + E L++ LE++ K L +++
Sbjct: 1039 GFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVND 1098
Query: 656 QEQAYLVHIEHLKSEVEEQKEQ 677
Q+ + ++ LK +V+E +E+
Sbjct: 1099 QKDQLSLRVKALKRQVDEAEEE 1120
Score = 49.3 bits (116), Expect = 1e-05
Identities = 83/404 (20%), Positives = 152/404 (37%), Gaps = 48/404 (11%)
Query: 30 GDIVE--LNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHS 87
G+ VE L +LQ+ E E+ LE+ L +Q E+ L + E R+ E
Sbjct: 756 GEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRAL--------EARLEEAQR 807
Query: 88 VIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTM 147
+A L ++ Q T R +E + R L + + E+ E R +D+ ++
Sbjct: 808 GLARLGQE----QQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN-------- 855
Query: 148 VTADMDNCS-DLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAI 206
+++ D LQ++ LE+ K VA+ R + + +E +
Sbjct: 856 --KELEKIGEDSKQALQQLQAQLEDY-----KEKARREVADAQRQAKDWASEAEKTSGGL 908
Query: 207 KTVEEIEGVLGRDLYPNLAE-ERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNA 265
+++ L + L + AE + +R +KEL R L E+E K + +
Sbjct: 909 SRLQDEIQRLRQALQASQAERDTARLDKELLAQR---------LQGLEQEAENKKRSQDD 959
Query: 266 IREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAK 325
+ L +V L+T L + T R+ ++ EL S+ +
Sbjct: 960 RARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSAR-----Q 1014
Query: 326 IAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHG 385
E K+S R R S S E LQ+ +E +T+
Sbjct: 1015 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQST 1074
Query: 386 SAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAE 429
+ E K++E ++ E +H+ Q D L++ ++ K +
Sbjct: 1075 NRKLERKVKELSIQIE---DERQHVNDQKDQLSLRVKALKRQVD 1115
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 76.3 bits (186), Expect = 1e-13
Identities = 161/853 (18%), Positives = 337/853 (39%), Gaps = 89/853 (10%)
Query: 13 SSAELSELHS------AALASLKGDIVELNKRLQQTERERDLL----EKKLAKAQCEQSH 62
S E+ ELH SL+ ++ EL++ +Q+ ++++D + E + + + E+S
Sbjct: 1352 SEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS- 1410
Query: 63 LMREHEDVQ------ERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSE 116
++ HED+ E+T L+ + E ++AE ++ + T +++++ +
Sbjct: 1411 -LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRS 1469
Query: 117 LSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGR 176
L Q++ + E R + ++ + Q + AD + + + +L + +V +
Sbjct: 1470 LLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAK 1529
Query: 177 KKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELA 236
LS + E+LT + I+ E E D + + +E E L
Sbjct: 1530 DSDFQCLS-----KKKEKLTEELQKLQKDIEMAERNE-----DHHLQVLKES---EVLLQ 1576
Query: 237 GLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPG 296
R E E L + + S+++E+ + +EE L+ + + + LQ G +
Sbjct: 1577 AKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT 1636
Query: 297 RLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGV 356
+ R + ELS ++ I++ ++ L K E + V+ ++S
Sbjct: 1637 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSK--- 1693
Query: 357 SSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESK-----IREFEVETERLNSRIEHLK 411
+ +++ LQ E+ H +SE + + E ++E E L + K
Sbjct: 1694 HKTELKNILDMLQ--LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQK 1751
Query: 412 SQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQS 471
+ + LE K ERM+ +S L + ++ + +E LA +
Sbjct: 1752 GEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTK---- 1807
Query: 472 LILGQFRAAGVGSSPGDQSGDE-------NITQMLKRAHDCRKTAENAAKALLMKLDGSC 524
+ AA +S +QS E + Q L + + + + N A+ +L
Sbjct: 1808 ----RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
Query: 525 GGAFAVAG--CSVQPWESLSSNS--HTSTTSSTASSCDTEFTKE-------------DEQ 567
++ +VQ +L+ HT+ S T K+ +E+
Sbjct: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
Query: 568 RLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKE 627
+ +Q L+N+ KL +++ E + + + +L+ L ++ +++
Sbjct: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMF---QRLQKERESEESKLETSKVTLKEQQHQLEK 1980
Query: 628 EMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS 687
E+ + K++L + + A E ++ T + +E+ + +E S+ + Q +R + L S
Sbjct: 1981 ELTDQKSKLDQVLSKVLAAEERVRTLQ-EEERWCESLEKTLSQTKRQLSEREQQLVE-KS 2038
Query: 688 GSKDKPGKECADAASPALSLAE---LRTTCSENELAAEFTNAIR-----REKKLKARVQE 739
G KE AD+ SL L + A A++ EK L + QE
Sbjct: 2039 GELLALQKE-ADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097
Query: 740 LVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVE 799
S +++ + E+ Q + E L + + + Y + KK+ N+ K LE + M + +
Sbjct: 2098 -NSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQ-KDLERRQMEISD 2155
Query: 800 RHETQVRMLKQRI 812
T +K I
Sbjct: 2156 AMRTLKSEVKDEI 2168
Score = 55.1 bits (131), Expect = 3e-07
Identities = 78/406 (19%), Positives = 160/406 (39%), Gaps = 34/406 (8%)
Query: 35 LNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNK 94
+NK+ QQ E D + ++AK E + E + E E +L VI+ L +
Sbjct: 567 MNKQYQQLESRLDEILSRIAK---ETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQE 623
Query: 95 KIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDN 154
+ ++G + ++E +LR E ++ Q T V +Q +V D +N
Sbjct: 624 YLGTIKGQATQAQNECRKLRDE-----------KETLLQRLTEVEQERDQLEIVAMDAEN 672
Query: 155 CSDLNSELQRVLTGLENVVCGRKKSSCSLSV--AEVDRHIEQLTTASEHCDLAIKTVEEI 212
+EL+ L V +++ LS AE++ + + ++ V +
Sbjct: 673 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRL 732
Query: 213 EGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDR 272
+ L L +ER + L + E KE+E + A + ++++ +
Sbjct: 733 TQLEQSALQAELEKERQALKNALGKAQFSEE--------KEQENSELHAKLKHLQDDNNL 784
Query: 273 LRRRVRELQTRLQSVQATGPSSP----GRLTSTNRPINPSTGELSTSSSSNDI--PIAKI 326
L++++++ Q L V G P R+ R + TGE++ S S+ + +A +
Sbjct: 785 LKQQLKDFQNHLNHV-VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADL 843
Query: 327 AERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQE-IFQTLYSHG 385
++ RS+ + V ++ + E LA ++ E + +
Sbjct: 844 QKQFSEILARSKWERDEAQVRERKLQE--EMALQQEKLATGQEEFRQACERALEARMNFD 901
Query: 386 SAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERM 431
E++I++ E E L ++ ++ L + L+E ER+
Sbjct: 902 KRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERI 947
Score = 49.7 bits (117), Expect = 1e-05
Identities = 137/773 (17%), Positives = 293/773 (37%), Gaps = 145/773 (18%)
Query: 49 LEKKLAKAQCEQSHLMREHEDVQ--ERTTLRYEERITELHSVI-----AELNKK------ 95
LE K K Q+ L H++++ E+ LR E +L I +E K
Sbjct: 439 LEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQL 498
Query: 96 ------IDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVT 149
+++L+ + E + + + E++ Q E+ + ++D + + +
Sbjct: 499 SGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKS 558
Query: 150 ADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTV 209
+N + Q++ + L+ ++ S + E+ EQLT + A+K
Sbjct: 559 GKEQQLDIMNKQYQQLESRLDEIL-----SRIAKETEEIKDLEEQLTEGQIAANEALK-- 611
Query: 210 EEIEGVLG--RDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIR 267
+++EGV+ ++ + + ++ + E LR+E E+L L E+E ++ + +
Sbjct: 612 KDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ----LEIVA 667
Query: 268 EERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIA 327
+ + +R+ + EL++ LQ S L T ++ EL + D ++
Sbjct: 668 MDAENMRKELAELESALQEQHEVNAS----LQQTQGDLSAYEAELEARLNLRDAEANQLK 723
Query: 328 ERV-KLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGS 386
E + K+++ S+ + L E ++ + A+
Sbjct: 724 EELEKVTRLTQLEQSALQAELEKERQALKNALGKAQ------------------------ 759
Query: 387 AISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALR 446
SE K E E L+++++HL+ N+LL L++ +++ ++ G A R
Sbjct: 760 -FSEEK----EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH--VVDGLVRPEEVAAR 812
Query: 447 LALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG------DENITQMLK 500
++ L L E ++ SP D G + +++L
Sbjct: 813 ---------VDELRRKLKLGTGEMNI-----------HSPSDVLGKSLADLQKQFSEILA 852
Query: 501 RAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTE 560
R+ R A+ + L ++ ++Q + + A
Sbjct: 853 RSKWERDEAQVRERKLQEEM-------------ALQQEKLATGQEEFRQACERALEARMN 899
Query: 561 FTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIH-IDPLSYDVKPRGDSQRLDLENAVLM 619
F D+++ + IQQ++N+ ++ + +E I + L Q D E ++
Sbjct: 900 F---DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQL--------QEADEEKERIL 948
Query: 620 QELMAM----KEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQK 675
+L + K E A+ + Q++ L+KE K L+ ++T + A E+ K
Sbjct: 949 AQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATA----------ELTIAK 998
Query: 676 EQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKA 735
+Q ++SL T + +E +A + A+ + E E + R+K +
Sbjct: 999 DQ-LKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQF 1057
Query: 736 RVQ-----------ELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYE 777
R++ V +E+L ++ E + + A N L S+ +E
Sbjct: 1058 RLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFE 1110
Score = 42.4 bits (98), Expect = 0.002
Identities = 81/399 (20%), Positives = 166/399 (41%), Gaps = 32/399 (8%)
Query: 28 LKGDIVELNKRLQQTERERDLLE----------KKLAKAQC---EQSHLMREHEDVQERT 74
L+ + L +RL + E+ERD LE K+LA+ + EQ + + Q
Sbjct: 642 LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDL 701
Query: 75 TLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQD 134
+ E L+ AE N+ + L+ T + E S L++EL + + + ++ +
Sbjct: 702 SAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL---KNALGKA 758
Query: 135 QTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLEN----VVCGR-KKSSCSLSVAEVD 189
Q S E +++ + A + + D N+ L++ L +N VV G + + V E+
Sbjct: 759 QFSEE-KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELR 817
Query: 190 RHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAE--ERSRWEKELAGLREENESLTA 247
R ++ T ++ I + ++ G DL +E RS+WE++ A +RE
Sbjct: 818 RKLKLGTG-----EMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEM 872
Query: 248 MLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINP 307
L ++ + + R R+ R+ + R+Q ++ L S
Sbjct: 873 ALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGL 932
Query: 308 STGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHS 367
+ +L + + +A++ E K K + E + S V G + + +VA +
Sbjct: 933 TDLQLQEADEEKERILAQLRELEK--KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA 990
Query: 368 LQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSR 406
+ + ++ ++L+ I++ + E + E ER + +
Sbjct: 991 TAELTIAKDQLKSLHGTVMKINQERAEELQ-EAERFSRK 1028
Score = 39.3 bits (90), Expect = 0.015
Identities = 64/289 (22%), Positives = 112/289 (38%), Gaps = 28/289 (9%)
Query: 16 ELSELHSAALASLKGDIVELNKRLQQTERERDL----LEKKLAKAQCEQSHLMREHEDVQ 71
EL+EL SA E+N LQQT+ + LE +L E + L E E V
Sbjct: 676 ELAELESALQEQH-----EVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVT 730
Query: 72 ERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSM 131
T L EL L + + Q + +E+ E SEL ++L Q + N + +
Sbjct: 731 RLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ-ENSELHAKLKHLQDDNNLLKQQL 789
Query: 132 DQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENV-----VCGRKKSSCSLSVA 186
Q ++ + +L +L ++ TG N+ V G+ + +
Sbjct: 790 KDFQNHLNHVVDGLVRPEEVAARVDELRRKL-KLGTGEMNIHSPSDVLGKSLADLQKQFS 848
Query: 187 EV------DRHIEQLTTASEHCDLAIKTV------EEIEGVLGRDLYPNLAEERSRWEKE 234
E+ +R Q+ ++A++ EE R L + ++ + E
Sbjct: 849 EILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEAR 908
Query: 235 LAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTR 283
+ + E L L S EE T + EE++R+ ++REL+ +
Sbjct: 909 IQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKK 957
Score = 39.3 bits (90), Expect = 0.015
Identities = 55/283 (19%), Positives = 123/283 (43%), Gaps = 49/283 (17%)
Query: 563 KEDEQRLKDYIQQLKND-------RAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLEN 615
+ + RL+D +Q LK+ RA+ + + E+E +H +D
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELH--------------HNID--- 1364
Query: 616 AVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLST--REAQEQAYLVHIEHLKSEVE- 672
L+QE +++ E+ EL + +++K ++ + + E + + L H E + E+E
Sbjct: 1365 -DLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIEC 1423
Query: 673 ------------EQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELA 720
+ ++ + S S +K+K SL + + E E
Sbjct: 1424 IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERR 1483
Query: 721 AEFT--NAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEK 778
A+ T N ++ +++L++ + A + + +I+ ++ + +N + A + K
Sbjct: 1484 AQETAVNLVKADQQLRS-----LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSK 1538
Query: 779 AKKKHQNKLKKLESQMMAMVERHET-QVRMLKQRIALLEEENS 820
K+K +L+KL+ + M ER+E +++LK+ LL+ + +
Sbjct: 1539 KKEKLTEELQKLQKD-IEMAERNEDHHLQVLKESEVLLQAKRA 1580
Score = 32.3 bits (72), Expect = 1.9
Identities = 59/316 (18%), Positives = 126/316 (39%), Gaps = 62/316 (19%)
Query: 546 HTSTTSSTASSCDTEFTK--EDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVK 603
+ T A+ E K ++++ L + +++ +R +++ ++ E++ + +
Sbjct: 624 YLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELE-- 681
Query: 604 PRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVH 663
Q NA L Q + AEL+A+L L + E L+ E ++ L
Sbjct: 682 --SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLK-----EELEKVTRLTQ 734
Query: 664 IEH--LKSEVEEQKEQRMRSLSSTS-SGSKDKPGKECADAASPALSLAELRTTCSENELA 720
+E L++E+E++++ +L S K++ E A+L+ +N L
Sbjct: 735 LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELH---------AKLKHLQDDNNLL 785
Query: 721 AE----FTNAIR-------REKKLKARVQELVSALERLTKSSEIRHQQSA--EFVNDLKR 767
+ F N + R +++ ARV EL L+ T I + + DL++
Sbjct: 786 KQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQK 845
Query: 768 ANSNLVAAYEKAKKKHQNKLKKLESQMMAMVER--------------------------H 801
S ++A + + + Q + +KL+ +M E+ H
Sbjct: 846 QFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQH 905
Query: 802 ETQVRMLKQRIALLEE 817
E +++ ++ I L+E
Sbjct: 906 EARIQQMENEIHYLQE 921
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 75.9 bits (185), Expect = 1e-13
Identities = 156/825 (18%), Positives = 327/825 (39%), Gaps = 88/825 (10%)
Query: 40 QQTERERDLLEK-----KLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVI-AELN 93
Q+ E E+ + EK +L E+ RE+E+ + Y E ++ L + E+N
Sbjct: 1156 QKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEIN 1215
Query: 94 KKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMD 153
++ ++++ED+ LR++L + E ++D + N S + +
Sbjct: 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSRE--------NRDLKDEIVRLNDSILQATEQR 1267
Query: 154 NCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEV-DRHIEQLTTASEHCDLAIKTVEEI 212
++ N+ LQ+ G E + +KK + + +V + E + + A KT+++
Sbjct: 1268 RRAEENA-LQQKACGSEIM---QKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDK 1323
Query: 213 EGVLGRDLYPNLAEERSRWE--KELAGLREE-NESLTAMLCSKEEELNRTKATMNAI--- 266
+ R E + RWE EL+ +R +E + ++ E E+N TK T++ +
Sbjct: 1324 NKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQ 1383
Query: 267 --------REERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSS 318
R + D L R R L ++ ++ T + L I + +T S
Sbjct: 1384 KEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQ---QKATGSEV 1440
Query: 319 NDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIF 378
+ E ++++ R+E S + L +I + E L + +N ++
Sbjct: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL 1500
Query: 379 QTLYSHGSAISESKIREFEVETERLNSR----IEHLKSQNDLLT---ITLEECKSNAERM 431
+ ++++ + + ++ NS I LK Q LT I E
Sbjct: 1501 ED--------ENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVK 1552
Query: 432 SMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSG 491
+ +++++ L+L Q E+ E L +E + G+ S +Q+
Sbjct: 1553 DQDITRFQNSLKELQLQKQKVEE--ELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAI 1610
Query: 492 D-ENITQMLKRAHDCRKTAENAAKALLMKLDGSC--------------GGAFAVAGCSVQ 536
N+TQ L++A +K +E+ + LDG A+ +Q
Sbjct: 1611 KITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQ 1670
Query: 537 PWESLSS----NSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELES 592
ES+ N H S E +K + +RL+ + L + ++ + L
Sbjct: 1671 EQESVKQAHLRNEHFQKAIEDKSRSLNE-SKIEIERLQSLTENLTKEHLMLEEELRNLR- 1728
Query: 593 IHIDPLSYDVKPRGDSQRLDLENAVLMQ---ELMAMKEEMAELKAQLYLLEKEKKALELK 649
L YD RG S+ +NA +++ +L EL+ + L++E++ L +
Sbjct: 1729 -----LEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQE 1783
Query: 650 LSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPG-KECADAASPALSLA 708
+ + Q I+ K++ + ++R L +DK + D + A S
Sbjct: 1784 IEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTL 1843
Query: 709 ELRTTCSENELAA--EFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLK 766
E T + + N + + K +R +E + +E + SE ++ ++++
Sbjct: 1844 EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE---REKNSLRSEIE 1900
Query: 767 RANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQR 811
R + + E+ ++K ++ ++ +SQ+ R++ ++ L+QR
Sbjct: 1901 RLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Score = 67.0 bits (162), Expect = 7e-11
Identities = 163/789 (20%), Positives = 300/789 (38%), Gaps = 151/789 (19%)
Query: 5 VAMKYGNDSSAELSELH--SAALASLKGDIVELNKR-LQQTERERDLLEKKLAKAQC--- 58
++M+ +DS ++L S LK +IV LN LQ TE+ R E L + C
Sbjct: 1224 ISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSE 1283
Query: 59 ---EQSHLMREHEDVQERTT---LRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSE 112
++ HL E + V ++ + R+++ + E I + NK+I+RL+ E E
Sbjct: 1284 IMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWE 1343
Query: 113 LRSELSQSQHEVNEDSRSM-DQDQTSVSI-----------PENQSTMVTADMDNCSDLNS 160
+ELS+ ++ +E+ S+ +Q +T ++I E ++ A +DN + N
Sbjct: 1344 YENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENR 1403
Query: 161 ELQRVLTGLENVV-----------------------CGRKKSSCSLSVAEVDR-HIEQLT 196
L + L+N + ++K + + +V + E+
Sbjct: 1404 SLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESV 1463
Query: 197 TASEHCDLAIKTVEEIEGVLGR-----DLYPN----LAEERSRWEKELAGLREENESLTA 247
+ D A KT+++ + R D N L +E +R ++ L++ N S T
Sbjct: 1464 RYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATE 1523
Query: 248 ---MLCSKEEELNRTKATMNAIREER-------DRLRRRVRELQTRLQSVQATGPSSPGR 297
L +E+EL R + + +ER R + ++ELQ + Q V+ R
Sbjct: 1524 TINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVE----EELNR 1579
Query: 298 LTST-------NRPINPSTGELSTSSSSNDIPIAKIA---ERVKLSKTRSESS-SSDRPV 346
L T + + + S I I + E+ + K RSE R V
Sbjct: 1580 LKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV 1639
Query: 347 LGSEISS--------IGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISES--KIREF 396
L + +SS V LQ+ ++++ AI + + E
Sbjct: 1640 LDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNES 1699
Query: 397 EVETERLNSRIEHLKSQNDLLTITLEECKSNAE--RMSMLVGKYESNATALRLALQY--- 451
++E ERL S E+L ++ +L L + + R + NAT L L Q
Sbjct: 1700 KIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQIS 1759
Query: 452 SEQCIEAYELLLALAESEQSL--ILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTA 509
+ + +E L+ L ++L + +F+ + +S Q TQ+++
Sbjct: 1760 NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQE-------- 1811
Query: 510 ENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRL 569
++LL+K ++ E + + E +QRL
Sbjct: 1812 ---RESLLVK---------------IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1853
Query: 570 KDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEM 629
+ QQ++ND K E ++++ E +E +++ E+
Sbjct: 1854 ECEKQQIQNDLNQWKTQYSRKEEA--------------IRKIESEREKSEREKNSLRSEI 1899
Query: 630 AELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQR-MRSLSSTSSG 688
L+A++ +E E+ +L+ STRE Q Q E E + QR + L G
Sbjct: 1900 ERLQAEIKRIE-ERCRRKLEDSTRETQSQL----------ETERSRYQREIDKLRQRPYG 1948
Query: 689 SKDKPGKEC 697
S + EC
Sbjct: 1949 SHRETQTEC 1957
Score = 51.6 bits (122), Expect = 3e-06
Identities = 165/890 (18%), Positives = 329/890 (36%), Gaps = 151/890 (16%)
Query: 14 SAELSELHSAALASLKGDIVELNKRLQQTERERD-----LLEKKLAKAQCEQSHL---MR 65
S L L L + K +++E RL + + L++ L K Q E S +
Sbjct: 1018 SEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
Query: 66 EHEDVQERTTL---RYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQH 122
E+++ + L ++ + + + I ELN+KI RL T EDE +S
Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL---TYEIEDEKRRRKSV------ 1128
Query: 123 EVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCS 182
E D + D DQ + C N G +K
Sbjct: 1129 EDRFDQQKNDYDQLQKA-------------RQCEKEN--------------LGWQKLESE 1161
Query: 183 LSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREEN 242
++ E + IE+L + + + EG R+ LA+ R+ + +E++ LR +
Sbjct: 1162 KAIKEKEYEIERL-----------RVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKY 1210
Query: 243 ESLTAMLCSKEEELNRTKATMNAI-----------REERDRLRRRVRELQTRLQSVQATG 291
E+ E+N TK T+ I R + DRL R R+L+ + +
Sbjct: 1211 ET----------EINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRL---- 1256
Query: 292 PSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKT---RSESSSSDRPVLG 348
+ L +T + L + ++I K ++L + RSE ++ + L
Sbjct: 1257 --NDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
Query: 349 SEISSIGVSSSVAEHLAHSLQ----------------------DCSNIQEIFQTLYSHGS 386
+I + E L Q + +++ F+T +
Sbjct: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
Query: 387 AISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESN---AT 443
+ E +T ++I++L +N L+ ++ K+ + + + + E +
Sbjct: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
Query: 444 ALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAH 503
A + +Q +E + +E+S+ Q + E + Q++ +
Sbjct: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
Query: 504 DCRKTAENAAKAL------LMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSC 557
+ RK E+ L L K + S Q L + + T
Sbjct: 1495 NDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQ 1554
Query: 558 D-TEFTKE------DEQRLKDYIQQLK----NDRAAVKLTMLELESIHIDPLSYDVKPRG 606
D T F +Q++++ + +LK D K ELE + +K
Sbjct: 1555 DITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITN 1614
Query: 607 DSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKAL-----ELKLSTREAQEQAYL 661
+Q+L+ + V + ++++ L L ++ ++ L E++ R+ ++
Sbjct: 1615 LTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQES 1674
Query: 662 VHIEHLKSE-VEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELA 720
V HL++E ++ E + RSL ++ K E + + L+ L L
Sbjct: 1675 VKQAHLRNEHFQKAIEDKSRSL------NESKIEIERLQSLTENLTKEHLMLEEELRNLR 1728
Query: 721 AEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAK 780
E+ + R + + + L + S R + +NDL+R NL EK +
Sbjct: 1729 LEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQ 1788
Query: 781 K---KHQNKLKKLESQMMAMVERHET---QVRMLKQ---RIALLEEENSR 821
K + N++++ ++Q +V+ E+ ++++L+Q R+ LE+E +R
Sbjct: 1789 KQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNR 1838
Score = 30.4 bits (67), Expect = 7.0
Identities = 55/286 (19%), Positives = 115/286 (40%), Gaps = 28/286 (9%)
Query: 560 EFTKEDEQRLKDYIQQLKNDR----AAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLEN 615
E+ E + Y +++ N R + +T ++ I + R RL EN
Sbjct: 1187 EYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSREN 1246
Query: 616 AVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQK 675
L E++ + + + L+A E+ AL+ K E ++ +HL+ E+++
Sbjct: 1247 RDLKDEIVRLNDSI--LQATEQRRRAEENALQQKACGSEIMQKK-----QHLEIELKQVM 1299
Query: 676 EQR-------MRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTN--- 725
+QR +SL + +DK KE + A+ R ENEL+ N
Sbjct: 1300 QQRSEDNARHKQSLEEAAKTIQDK-NKEIERLKAEFQEEAKRRWE-YENELSKVRNNYDE 1357
Query: 726 -AIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKK--- 781
I + + + + + + +LT E +++L R N +L ++ K
Sbjct: 1358 EIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLT 1417
Query: 782 KHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNET 827
+ L+++E + + ++V KQ++ + + ++ T E+
Sbjct: 1418 QTTENLRRVEEDIQQQ-KATGSEVSQRKQQLEVELRQVTQMRTEES 1462
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 75.9 bits (185), Expect = 1e-13
Identities = 167/818 (20%), Positives = 304/818 (37%), Gaps = 139/818 (16%)
Query: 13 SSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQE 72
SS+ + S + AS GDI LQ + + L+K+LA R + D E
Sbjct: 189 SSSSGNNFLSGSPASPMGDI------LQTPQFQMRRLKKQLADE--------RSNRDELE 234
Query: 73 RTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMD 132
+ +TE + IA + ++IDRL + E+ S L + + + NE S +M
Sbjct: 235 LELAENRKLLTEKDAQIAMMQQRIDRL--ALLNEKQAASPLEPKELEELRDKNE-SLTMR 291
Query: 133 QDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHI 192
+T + C DL +E +++DR I
Sbjct: 292 LHET---------------LKQCQDLKTE-----------------------KSQMDRKI 313
Query: 193 EQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSK 252
QL + E+ DL+ K E A + + L L EE+ T K
Sbjct: 314 NQL--SEENGDLSFKLRE-------------FASHLQQLQDALNELTEEHSKATQEWLEK 358
Query: 253 ----EEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPS 308
E+EL+ + E+ + L+ ++ +L+ L +Q P G + +
Sbjct: 359 QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
Query: 309 TGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSL 368
E +T +++N ++ RV++ +T E + +L H
Sbjct: 419 KQEAATLAANN----TQLQARVEMLET--ERGQQEAKLLAER-----------GHFEEEK 461
Query: 369 QDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNA 428
Q S++ Q+ S+ S E + + RL +++ L S+ L T+++
Sbjct: 462 QQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQ---QD 518
Query: 429 ERMSMLVGKYESNATALRLALQYSEQCIEAY-----ELLLALAESEQSLILGQFRAAGVG 483
+ ++ L + + L LQ EQ + +L +L + EQ L
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL---------KE 569
Query: 484 SSPGDQSGDENITQMLKRAHDCRKTA---ENAAKALLMKLDGSCGGAFAVAGCSVQPWES 540
+ ++ ++ Q L A + R+ + +AA L L+ + +Q
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Query: 541 LSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSY 600
++ TS T + + E+ Q + +Q +++ A ++ LEL+ L
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE-AQAQVAELELQ------LRS 682
Query: 601 DVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAY 660
+ + + +R+ E L ++L A+KE + K LE+EK+ L E Q++
Sbjct: 683 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGS---LEEEKRRAADAL---EEQQRC- 735
Query: 661 LVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLA-ELRTTCSENEL 719
I LK+E EQ R +++ G++ +A L A + T EL
Sbjct: 736 ---ISELKAETRSLVEQHKRERKEL---EEERAGRKGLEARLQQLGEAHQAETEVLRREL 789
Query: 720 AAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDL-------KRANSNL 772
A E + + V+E+ + ER S + Q A F L ++A L
Sbjct: 790 AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL 849
Query: 773 VAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQ 810
A EK + ++ Q + E H R L+Q
Sbjct: 850 QEAKEKVAGIESHSELQISRQQNELAELHANLARALQQ 887
Score = 72.4 bits (176), Expect = 2e-12
Identities = 181/867 (20%), Positives = 339/867 (39%), Gaps = 126/867 (14%)
Query: 26 ASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 85
A+L + +L R++ E ER E KL E+ H E+ Q+ ++L IT+L
Sbjct: 423 ATLAANNTQLQARVEMLETERGQQEAKLL---AERGHF---EEEKQQLSSL-----ITDL 471
Query: 86 HSVIAELNKKIDRLQGTT----IREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIP 141
S I+ L++ + L+ + R + + L SEL+ + + + + +
Sbjct: 472 QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
Query: 142 ENQSTMVTADMDNCSD-LNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASE 200
+ Q + S L +++++ + L+ K+ + D H +QL TA+E
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD-HAQQLATAAE 590
Query: 201 HC-------DLAIKTVEEIEG-------VLGRDLY-PNLAEERSRW-----EKELAGLRE 240
D A+K +E +E +L + L N A + ++ ++E A L
Sbjct: 591 EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650
Query: 241 ENESLTAMLCSKEEELNRTKATMNAIR----------EERDRLRRRVRELQTRLQSVQAT 290
+ E L A + + +E + +A + + E++R+ + +LQ +LQ+++ +
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKES 710
Query: 291 GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSE 350
+ G L R + E S + E+ K + E + R L +
Sbjct: 711 LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770
Query: 351 ISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESK--IREFEVETERL-NSRI 407
+ +G AH + +E+ + + + +A SE + ++E ER +S+
Sbjct: 771 LQQLGE--------AHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 408 EHLKS----QNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLL 463
E + Q L+T+ EEC+ R + K + LQ S Q E EL
Sbjct: 823 EEAQYGAMFQEQLMTLK-EECEK--ARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879
Query: 464 ALAESEQSLILGQFRAAGVGSSPGD-----QSGDENITQMLKRAHDCRKTAENAAKALLM 518
LA + Q + + RA + + + + ++ + E A++ L+
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVK 939
Query: 519 K-----------LDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQ 567
+ L+ G F ++Q E + A+ +++ +++E+
Sbjct: 940 EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999
Query: 568 RLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKE 627
+ +R +LT E D L+ + R + + + L+NA+ Q +
Sbjct: 1000 G--------QQEREVARLTQ-ERGRAQAD-LALEKAARAELE-MRLQNALNEQRV----- 1043
Query: 628 EMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSS 687
E A L+ L EK+ + +L+ E A + +E L+ V++ KEQ + +S
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103
Query: 688 GSKDKPGKECADAASPA--------LSLAELRTTC-SENELAAEFTNAIRREKKLKARVQ 738
GS + E A P +++L C + E A ++ E+ +A
Sbjct: 1104 GSGAQ--SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA--- 1158
Query: 739 ELVSALERL-----TKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQ 793
E SALE L K+ E+ H QSA L A L AA+ + H K E +
Sbjct: 1159 ERDSALETLQGQLEEKAQELGHSQSA-----LASAQREL-AAFRTKVQDH----SKAEDE 1208
Query: 794 MMAMVERHETQVRMLKQRIALLEEENS 820
A V R + I+ LEEE S
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVS 1235
Score = 64.7 bits (156), Expect = 3e-10
Identities = 163/882 (18%), Positives = 342/882 (38%), Gaps = 147/882 (16%)
Query: 35 LNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERT-TLRYEERITELHSVIAELN 93
L ++LQ RD + + +AQ E++ L R+ E++Q T R E+ E + +AEL
Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH--EAQAQVAELE 677
Query: 94 KKIDRLQGTTIREE---DEYSELRSELSQSQHEVNEDSRSMDQDQT-SVSIPENQSTMVT 149
++ Q +E E +L+ +L + + S+++++ + E Q ++
Sbjct: 678 LQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737
Query: 150 ADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTV 209
L + +R LE GRK ++ ++QL A +
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKG---------LEARLQQLGEAHQ--------- 779
Query: 210 EEIEGVLGRDLYPNLAEERS------RWEKELAGLREENESLTAMLCSKEEELN---RTK 260
E E VL R+L +A + + + KE+A RE E S++EE +
Sbjct: 780 AETE-VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED------SQQEEAQYGAMFQ 832
Query: 261 ATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSND 320
+ ++EE ++ R+ ++E + ++ +++ R + ++ + +
Sbjct: 833 EQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKE 892
Query: 321 IPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVA--EHLAHSLQDCSNIQEIF 378
+ K+A+ + + + ++S + L + + G A E + + E
Sbjct: 893 VRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
Query: 379 QTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKY 438
+ +++ ++ E E E++ + +E L++ +E + ER + +
Sbjct: 953 EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE 1012
Query: 439 ESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQM 498
A A LAL+ + + E+ L A +EQ + + A + + D+ + ++
Sbjct: 1013 RGRAQA-DLALEKAARA--ELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKL 1069
Query: 499 -------LKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCS----------------- 534
+K + R+T + + L K G+ A + +
Sbjct: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV 1129
Query: 535 ------VQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQ-RLKDYIQQLKNDRAAVKLTM 587
Q + + + S + AS + + E Q +L++ Q+L + ++A+
Sbjct: 1130 SKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
Query: 588 LELESIHIDPLSYD-------VKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLE 640
EL + + + Q + +N+++ +++EE++ L Q+ LE
Sbjct: 1190 RELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS----SLEEEVSILNRQV--LE 1243
Query: 641 KEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADA 700
KE ++ ELK + +SE ++ E+R+R L + ++ + + + +
Sbjct: 1244 KEGESKELK-------------RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL 1290
Query: 701 ASPALSL---AELRTTCSENELAAEFTNAIRREKKLKARV---QELVSALERLTKSSEIR 754
SL AE + SEN L E T+ R ++L + QE E+ + ++
Sbjct: 1291 REEVQSLREEAEKQRVASEN-LRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLE 1349
Query: 755 HQQSAEFVNDL---KRANSNLVAAYEKAKKKHQNKLKKLES------------------- 792
H + V++L K L A A+K+H+ +L++ +
Sbjct: 1350 HTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGEL 1409
Query: 793 ----QMMAMVERHETQVR-----------MLKQRIALLEEEN 819
Q +A ER Q+R MLK+ LL EEN
Sbjct: 1410 IPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEEN 1451
Score = 52.4 bits (124), Expect = 2e-06
Identities = 144/749 (19%), Positives = 281/749 (37%), Gaps = 89/749 (11%)
Query: 23 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDV-QERTTLRYEE- 80
A LA K EL RLQ E+ + + A Q +H + E E QE LR E
Sbjct: 1018 ADLALEKAARAELEMRLQNALNEQRV---EFATLQEALAHALTEKEGKDQELAKLRGLEA 1074
Query: 81 -RITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVS 139
+I EL EL + + +L+ ++E E++ S++ ++ + VS
Sbjct: 1075 AQIKELE----ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130
Query: 140 IPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTAS 199
E Q C + + LE R + +L + +E+
Sbjct: 1131 KLEQQ----------CQKQQEQADSLERSLEAERASRAERDSALETLQ--GQLEEKAQEL 1178
Query: 200 EHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEE---L 256
H A+ + + E R + ++ W+ ++A R+E E +++ S EEE L
Sbjct: 1179 GHSQSALASAQR-ELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237
Query: 257 NRTKATMNAIREERDRL----RRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGEL 312
NR +E RL + ++L+ RL+ +QA S+ R + + L
Sbjct: 1238 NRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297
Query: 313 STSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEI--SSIGVSSSVAEHLAHS--L 368
+ + + + + R+E + + +S+ EH + +
Sbjct: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357
Query: 369 QDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNS-RIEHLKSQNDLLTITLEECKSN 427
+ + + Q L + +A + E E + R E L++Q +L
Sbjct: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL---------GE 1408
Query: 428 AERMSMLVGKYESNATALRL-ALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSP 486
+ V + E A LR Y+EQ L++ + L+ + R G ++
Sbjct: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQ--------LSMLKKAHGLLAEENRGLGERANL 1460
Query: 487 GDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSH 546
G Q + + Q ++ A+ L ++ A + + E +++
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE-------AQSTARELEVMTAKYE 1513
Query: 547 TSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRG 606
+ + + +E+ Q+L ++QL+ ++ ++ LS K
Sbjct: 1514 GAKVKVLE---ERQRFQEERQKLTAQVEQLE--------VFQREQTKQVEELS---KKLA 1559
Query: 607 DSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEH 666
DS D + V Q+L A++ + E + + L+ + L+ +LS +E + Y + +E
Sbjct: 1560 DS---DQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEK 1616
Query: 667 LKSEVEEQKEQ------RMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELA 720
K+ + +K+Q ++RSL +K+ + A+ L A L+T +E +
Sbjct: 1617 AKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAE--AERLGHELQQAGLKTKEAE-QTC 1673
Query: 721 AEFTNAIRREKKLKARVQELVSALERLTK 749
T +R L+A+V L L K
Sbjct: 1674 RHLTAQVR---SLEAQVAHADQQLRDLGK 1699
Score = 37.4 bits (85), Expect = 0.058
Identities = 59/296 (19%), Positives = 121/296 (40%), Gaps = 26/296 (8%)
Query: 19 ELHSAALASLKGD----IVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERT 74
E + LA+++ D + E+ + Q T RE +++ K A+ + + ++ +++
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKL 1533
Query: 75 TLRYEERIT---ELHSVIAELNKKI-DRLQGTTIREED------EYSELRSELSQSQHEV 124
T + E+ E + EL+KK+ D Q + ++++ + E + E + Q ++
Sbjct: 1534 TAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQL 1593
Query: 125 NEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLS 184
NE + Q + + + Q D N ELQ L LE + K+
Sbjct: 1594 NELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELR---- 1649
Query: 185 VAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENES 244
AE +R +L A A +T + + R L +A + ++L + ++
Sbjct: 1650 -AEAERLGHELQQAGLKTKEAEQTCRHLTAQV-RSLEAQVAHADQQL-RDLGKFQVATDA 1706
Query: 245 LTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTS 300
L + + +L+ + +++ EE L + ++L Q G S PG S
Sbjct: 1707 LKSREPQAKPQLDLSIDSLDLSCEEGTPL-----SITSKLPRTQPDGTSVPGEPAS 1757
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.122 0.320
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,523,515
Number of Sequences: 37866
Number of extensions: 1109146
Number of successful extensions: 13041
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 217
Number of HSP's successfully gapped in prelim test: 861
Number of HSP's that attempted gapping in prelim test: 7471
Number of HSP's gapped (non-prelim): 4566
length of query: 829
length of database: 18,247,518
effective HSP length: 111
effective length of query: 718
effective length of database: 14,044,392
effective search space: 10083873456
effective search space used: 10083873456
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.