Search of human proteins with 4504545

Search of human proteins with 4504545

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
         (440 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi...   887   0.0  
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  207   2e-53
gi|4503383 dopamine receptor D1 [Homo sapiens]                        204   2e-52
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               197   2e-50
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                184   1e-46
gi|4503391 dopamine receptor D5 [Homo sapiens]                        178   8e-45
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                178   8e-45
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]           178   1e-44
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]            178   1e-44
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    177   2e-44
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   176   5e-44
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   175   6e-44
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]         174   2e-43
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]         174   2e-43
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]         174   2e-43
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]         174   2e-43
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]         174   2e-43
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]         174   2e-43
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa...   172   5e-43
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]        170   3e-42
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    169   4e-42
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    169   4e-42
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    169   4e-42
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    169   4e-42
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   167   2e-41
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap...   166   5e-41
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]            165   7e-41
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      162   7e-40
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             160   3e-39
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   158   8e-39

>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
           sapiens]
          Length = 440

 Score =  887 bits (2291), Expect = 0.0
 Identities = 440/440 (100%), Positives = 440/440 (100%)

Query: 1   MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT 60
           MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
Sbjct: 1   MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT 60

Query: 61  SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI 120
           SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
Sbjct: 61  SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI 120

Query: 121 SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC 180
           SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
Sbjct: 121 SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC 180

Query: 181 RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP 240
           RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
Sbjct: 181 RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP 240

Query: 241 RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG 300
           RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
Sbjct: 241 RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG 300

Query: 301 LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP 360
           LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
Sbjct: 301 LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP 360

Query: 361 RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF 420
           RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
Sbjct: 361 RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF 420

Query: 421 FNIDPAEPELRPHPLGIPTN 440
           FNIDPAEPELRPHPLGIPTN
Sbjct: 421 FNIDPAEPELRPHPLGIPTN 440


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  207 bits (526), Expect = 2e-53
 Identities = 141/423 (33%), Positives = 208/423 (49%), Gaps = 40/423 (9%)

Query: 1   MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT 60
           +VP   P +   PA  +  P +   +  +   + +++ L  A N L+I  I   P L+  
Sbjct: 33  LVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTL 92

Query: 61  SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI 120
           +N F++SL ++DL++GL+V+P      ++GRW      C LWT+ DV+C +ASI  LC+I
Sbjct: 93  TNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVI 152

Query: 121 SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGW--HELGHARPPV-- 176
           +LDRYL I SP RY+  +T  RA  LV   W+++AL SFLP+L+ W   E   AR     
Sbjct: 153 ALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYND 212

Query: 177 PGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASL----------- 225
           P  C  + +  + + +S ++F++P   + F Y R+   A+KQ  ++ S            
Sbjct: 213 PKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARP 272

Query: 226 TTGMASQASETLQVPRTPRPGVESADS------------RRLATKHSRKALKASLTLGIL 273
            +   S        P  PRP   +A +             RL     +KALK   TLGI+
Sbjct: 273 PSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALK---TLGII 329

Query: 274 LGMFFVTWLPFFVANIVQAV-CDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALG 332
           +G+F + WLPFF+AN+V+A   + +   LF    WLGY NS  NPIIY     DF++A  
Sbjct: 330 MGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQ 388

Query: 333 RFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLP-PDSDSDSDAGSGGSSG 391
             L C R    R+ +      R S    RPG       P P P   SD D D   G +  
Sbjct: 389 GLLCCARRAARRRHATHGDRPRASGCLARPG-------PPPSPGAASDDDDDDVVGATPP 441

Query: 392 LRL 394
            RL
Sbjct: 442 ARL 444


>gi|4503383 dopamine receptor D1 [Homo sapiens]
          Length = 446

 Score =  204 bits (518), Expect = 2e-52
 Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 36/400 (9%)

Query: 30  AAALCVVIALTAAANSLLIALICTQPALRN-TSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
           A  L ++I  T   N+L+ A +     LR+  +NFF++SL  SDL+V ++VMP   +  +
Sbjct: 27  ACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEI 86

Query: 89  YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVL 148
            G W      C +W AFD+MC +ASILNLC+IS+DRY  I SP RY+ +MTP  A  L+ 
Sbjct: 87  AGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILIS 145

Query: 149 GAWSLAALASFLPLLLGWHELGHARPPVPG------------QCRLLASLPFVLVASGLT 196
            AW+L+ L SF+P+ L WH+   A+P  P              C    S  + + +S ++
Sbjct: 146 VAWTLSVLISFIPVQLSWHK---AKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVIS 202

Query: 197 FFLPSGAICFTYCRILLAARKQAVQVASL-TTGMASQASETLQVPRTPRPGVESADSRRL 255
           F++P   +  TY RI   A+KQ  ++A+L    + ++  +T      P    +   S ++
Sbjct: 203 FYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKM 262

Query: 256 ATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCD-------CISPGLFDVLTWL 308
           + K   K LK   TL +++G+F   WLPFF+ N +   C        CI    FDV  W 
Sbjct: 263 SFKRETKVLK---TLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWF 319

Query: 309 GYCNSTMNPIIYPLFMRDFKRALGRFLPCPR-CPRERQA------SLASPSLRTSHSGPR 361
           G+ NS++NPIIY  F  DF++A    L C R CP    A      +    ++ +SH  PR
Sbjct: 320 GWANSSLNPIIY-AFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPR 378

Query: 362 PGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLP 401
             +S +  L   +P    S  D     ++G+    + L P
Sbjct: 379 GSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSP 418


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  197 bits (500), Expect = 2e-50
 Identities = 132/382 (34%), Positives = 194/382 (50%), Gaps = 31/382 (8%)

Query: 7   PTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLV 66
           PT     A  +G P  P  +    A L + +  T   N L+I  I   P L+  +N F+ 
Sbjct: 18  PTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVT 77

Query: 67  SLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYL 126
           SL  +DL++GL+V+PPA   AL G W L    C LWT+ DV+C +ASI  LC +++DRYL
Sbjct: 78  SLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYL 137

Query: 127 LILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELG--------HARPPVPG 178
            + +PLRY   +T   A   V+  W ++A  SF P++  W  +G        H+ P    
Sbjct: 138 AVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRC-- 195

Query: 179 QCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQ----AVQVASLTTGMASQAS 234
            C   +++P+VL++S ++F+LP   + F Y R+ + A +Q      ++       +  A 
Sbjct: 196 -CAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAP 254

Query: 235 ETLQVPR-----TPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANI 289
                P       P  GV  A  RR A     +  +A  TLG+++G F + WLPFF+AN+
Sbjct: 255 SRSLAPAPVGTCAPPEGV-PACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANV 313

Query: 290 VQAV-CDCISPG-LFDVLTWLGYCNSTMNPIIY---PLFMRDFKRAL---GRFLPCPRCP 341
           ++A+    + PG  F  L WLGY NS  NP+IY   P F   F+R L   GR LP   C 
Sbjct: 314 LRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCA 373

Query: 342 RERQASLAS--PSLRTSHSGPR 361
             R A   S  P+ R+S + PR
Sbjct: 374 AARPALFPSGVPAARSSPAQPR 395


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  184 bits (467), Expect = 1e-46
 Identities = 122/359 (33%), Positives = 180/359 (50%), Gaps = 29/359 (8%)

Query: 6   GPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFL 65
           G   N T A G    SA G    V   L   I +  A N L+I  +     L+  +N+F+
Sbjct: 78  GGDVNGTAAVGGLVVSAQGVG--VGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFI 135

Query: 66  VSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRY 125
           V+L  +DL++   V+P +    + G W   R  C +W A DV+CC+ASIL+LC IS+DRY
Sbjct: 136 VNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRY 195

Query: 126 LLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLAS 185
           + +   L+Y   MT  +A A++   W +A + S  PLL GW E     PP    C +   
Sbjct: 196 VGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLL-GWKE---PVPPDERFCGITEE 251

Query: 186 LPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP----- 240
             + + +S  +F+LP   I   YCR+ + AR       SL  G+  +  +  +V      
Sbjct: 252 AGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTT---RSLEAGVKRERGKASEVVLRIHC 308

Query: 241 RTPRPGVESADSRRLATKHS-RKAL-----------KASLTLGILLGMFFVTWLPFFVAN 288
           R    G + A   R A  H+ R +L           KA+ TL I++G+F + W PFF   
Sbjct: 309 RGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVL 368

Query: 289 IVQAVCDCISP--GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQ 345
            + ++   + P  G+F V+ WLGY NS +NP+IYP   R+FKRA  R L C +C R R+
Sbjct: 369 PLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRC-QCRRRRR 426


>gi|4503391 dopamine receptor D5 [Homo sapiens]
          Length = 477

 Score =  178 bits (452), Expect = 8e-45
 Identities = 122/356 (34%), Positives = 173/356 (48%), Gaps = 46/356 (12%)

Query: 17  AGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALR-NTSNFFLVSLFTSDLMV 75
           AG P         A  L ++I  T   N L+ A I     LR N +N F+VSL  SDL V
Sbjct: 31  AGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFV 90

Query: 76  GLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYK 135
            L+VMP   +  + G W      C +W AFD+MC +ASILNLC+IS+DRY  I  P RYK
Sbjct: 91  ALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYK 149

Query: 136 LRMTPLRALALVLGAWSLAALASFLPLLLGWH----------------------ELGHAR 173
            +MT   AL +V  AW+L+ L SF+P+ L WH                      E     
Sbjct: 150 RKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWE 209

Query: 174 PPVPGQ-CRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQ 232
           P V  + C    +  + + +S ++F++P   +  TY RI   A+ Q  +++SL      +
Sbjct: 210 PDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSL-----ER 264

Query: 233 ASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQA 292
           A+E  Q  R+         S R + K   K LK   TL +++G+F   WLPFF+ N +  
Sbjct: 265 AAEHAQSCRSSAACAPDT-SLRASIKKETKVLK---TLSVIMGVFVCCWLPFFILNCMVP 320

Query: 293 VCD-----------CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337
            C            C+S   FDV  W G+ NS++NP+IY  F  DF++   + L C
Sbjct: 321 FCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIY-AFNADFQKVFAQLLGC 375


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  178 bits (452), Expect = 8e-45
 Identities = 108/322 (33%), Positives = 167/322 (51%), Gaps = 17/322 (5%)

Query: 29  VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
           V   L   I      N L+I  +     LR  +N+F+V+L  +DL++   V+P +    +
Sbjct: 48  VGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEV 107

Query: 89  YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVL 148
            G WVL R  C +W A DV+CC+ASIL+LC IS+DRY+ +   L+Y   +T  +A+  +L
Sbjct: 108 LGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALL 167

Query: 149 GAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTY 208
             W L+ + S  P LLGW E     P    +C +     + L +S  +F++P   I   Y
Sbjct: 168 SVWVLSTVISIGP-LLGWKE---PAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMY 223

Query: 209 CRILLAARKQAVQV-ASLTTGMASQASETLQV----------PRTPRPGVESADSRRLAT 257
           CR+ + A++    + A +   M++    TL++            T   G     S  +  
Sbjct: 224 CRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKL 283

Query: 258 KHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISP--GLFDVLTWLGYCNSTM 315
               +  KA+ TLGI++GMF + WLPFF+A  + ++   + P   +F V+ WLGY NS +
Sbjct: 284 FKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCL 343

Query: 316 NPIIYPLFMRDFKRALGRFLPC 337
           NPIIYP   ++FKRA  R L C
Sbjct: 344 NPIIYPCSSKEFKRAFVRILGC 365


>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
          Length = 397

 Score =  178 bits (451), Expect = 1e-44
 Identities = 118/370 (31%), Positives = 185/370 (50%), Gaps = 42/370 (11%)

Query: 29  VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
           +   L V+I +T A N ++   +     LRN +N F+VSL  +DL++GL+V+P + +  L
Sbjct: 21  ITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL 80

Query: 89  YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLR-ALALV 147
             +W   +  C ++T+ DVM C+ASILNL +ISLDRY  ++ PLRY + +TP+R A++LV
Sbjct: 81  SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV 140

Query: 148 LGAWSLAALASFLPLLLGWHELGHARPP--VPGQCRLLASLPFVLVASGLTFFLPSGAIC 205
           L  W ++   SFL + LGW+             +C++  +  + LV   +TF+LP   +C
Sbjct: 141 L-IWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMC 199

Query: 206 FTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALK 265
            TY RI   AR QA ++  +++  A+   E                             K
Sbjct: 200 ITYYRIFKVARDQAKRINHISSWKAATIREH----------------------------K 231

Query: 266 ASLTLGILLGMFFVTWLPFFVANIVQAVC--DCISPGLFDVLTWLGYCNSTMNPIIYPLF 323
           A++TL  ++G F + W P+F A + + +   D I+  L  ++ WLGY NS +NPI+Y   
Sbjct: 232 ATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAAL 291

Query: 324 MRDFKRALGRFLPCPRCPRERQ----ASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSD 379
            RDF+    +   C    R        S AS   RT    PR     Q+  PL L   S 
Sbjct: 292 NRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQ----QEEKPLKLQVWSG 347

Query: 380 SDSDAGSGGS 389
           ++  A  G +
Sbjct: 348 TEVTAPQGAT 357


>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
          Length = 359

 Score =  178 bits (451), Expect = 1e-44
 Identities = 118/370 (31%), Positives = 185/370 (50%), Gaps = 42/370 (11%)

Query: 29  VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
           +   L V+I +T A N ++   +     LRN +N F+VSL  +DL++GL+V+P + +  L
Sbjct: 21  ITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL 80

Query: 89  YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLR-ALALV 147
             +W   +  C ++T+ DVM C+ASILNL +ISLDRY  ++ PLRY + +TP+R A++LV
Sbjct: 81  SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV 140

Query: 148 LGAWSLAALASFLPLLLGWHELGHARPP--VPGQCRLLASLPFVLVASGLTFFLPSGAIC 205
           L  W ++   SFL + LGW+             +C++  +  + LV   +TF+LP   +C
Sbjct: 141 L-IWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMC 199

Query: 206 FTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALK 265
            TY RI   AR QA ++  +++  A+   E                             K
Sbjct: 200 ITYYRIFKVARDQAKRINHISSWKAATIREH----------------------------K 231

Query: 266 ASLTLGILLGMFFVTWLPFFVANIVQAVC--DCISPGLFDVLTWLGYCNSTMNPIIYPLF 323
           A++TL  ++G F + W P+F A + + +   D I+  L  ++ WLGY NS +NPI+Y   
Sbjct: 232 ATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAAL 291

Query: 324 MRDFKRALGRFLPCPRCPRERQ----ASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSD 379
            RDF+    +   C    R        S AS   RT    PR     Q+  PL L   S 
Sbjct: 292 NRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQ----QEEKPLKLQVWSG 347

Query: 380 SDSDAGSGGS 389
           ++  A  G +
Sbjct: 348 TEVTAPQGAT 357


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  177 bits (449), Expect = 2e-44
 Identities = 122/387 (31%), Positives = 181/387 (46%), Gaps = 33/387 (8%)

Query: 8   TANSTPAWGAGPPSAPGGSGWV----------AAALCVVIALTAAANSLLIALICTQPAL 57
           TA+  P W A P +A G    +           + L ++  LT A N L++  +C    L
Sbjct: 53  TASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKL 112

Query: 58  RNTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGRWVLARGLCLLWTAFDVMCCSASILN 116
           R  SN+ +VSL  +DL V + VMP  ++ + + G+W+     C ++ A DVMCC+ASI+ 
Sbjct: 113 RQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMT 172

Query: 117 LCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV 176
           LC+IS+DRYL I  PL Y +R        ++L  W L+A  + LP L GW +        
Sbjct: 173 LCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGWAQ----NVND 227

Query: 177 PGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAV--QVASLTTGMASQAS 234
              C +     + + ++ + F++P   + F Y +I  AARK A   +             
Sbjct: 228 DKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVI 287

Query: 235 ETLQVPRTPRPGVESADSRRLATKHSRKAL-------KASLTLGILLGMFFVTWLPFFVA 287
               + +  +   E A+  RL  KH RK +       KA+ TLGI++G F V WLPFF+ 
Sbjct: 288 ALNGIVKLQKEVEECANLSRL-LKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLL 346

Query: 288 N-----IVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPR 342
           +     I    C CI   +     WLGY NS +NP IY  F RD +      L C     
Sbjct: 347 STARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNI 406

Query: 343 ERQASLAS--PSLRTSHSGPRPGLSLQ 367
            R+ S A    +L+ +    RP   LQ
Sbjct: 407 NRKLSAAGMHEALKLAERPERPEFVLQ 433


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  176 bits (445), Expect = 5e-44
 Identities = 121/387 (31%), Positives = 181/387 (46%), Gaps = 33/387 (8%)

Query: 8   TANSTPAWGAGPPSAPGGSGWV----------AAALCVVIALTAAANSLLIALICTQPAL 57
           TA+  P W A P +A G    +           + L ++  LT A N L++  +C    L
Sbjct: 53  TASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKL 112

Query: 58  RNTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGRWVLARGLCLLWTAFDVMCCSASILN 116
           R  SN+ +VSL  +DL V + VMP  ++ + + G+W+     C ++ A DVMCC+ASI+ 
Sbjct: 113 RQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMT 172

Query: 117 LCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV 176
           LC+IS+DRYL I  PL Y +R        ++L  W L+A  + LP L GW +        
Sbjct: 173 LCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGWAQ----NVND 227

Query: 177 PGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAV--QVASLTTGMASQAS 234
              C +     + + ++ + F++P   + F Y +I  AARK A   +             
Sbjct: 228 DKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVI 287

Query: 235 ETLQVPRTPRPGVESADSRRLATKHSRKAL-------KASLTLGILLGMFFVTWLPFFVA 287
               + +  +   E A+  RL  KH RK +       KA+ TLGI++G F V WLPFF+ 
Sbjct: 288 ALNGIVKLQKEVEECANLSRL-LKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLL 346

Query: 288 N-----IVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPR 342
           +     I    C CI   +     WLGY NS +NP IY  F RD +      L C     
Sbjct: 347 STARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNI 406

Query: 343 ERQASLAS--PSLRTSHSGPRPGLSLQ 367
            R+ S A    +L+ +    RP   L+
Sbjct: 407 NRKLSAAGMHEALKLAERPERPEFVLR 433


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  175 bits (444), Expect = 6e-44
 Identities = 120/382 (31%), Positives = 179/382 (46%), Gaps = 33/382 (8%)

Query: 8   TANSTPAWGAGPPSAPGGSGWV----------AAALCVVIALTAAANSLLIALICTQPAL 57
           TA+  P W A P +A G    +           + L ++  LT A N L++  +C    L
Sbjct: 53  TASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKL 112

Query: 58  RNTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGRWVLARGLCLLWTAFDVMCCSASILN 116
           R  SN+ +VSL  +DL V + VMP  ++ + + G+W+     C ++ A DVMCC+ASI+ 
Sbjct: 113 RQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMT 172

Query: 117 LCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV 176
           LC+IS+DRYL I  PL Y +R        ++L  W L+A  + LP L GW +        
Sbjct: 173 LCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGWAQ----NVND 227

Query: 177 PGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAV--QVASLTTGMASQAS 234
              C +     + + ++ + F++P   + F Y +I  AARK A   +             
Sbjct: 228 DKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVI 287

Query: 235 ETLQVPRTPRPGVESADSRRLATKHSRKAL-------KASLTLGILLGMFFVTWLPFFVA 287
               + +  +   E A+  RL  KH RK +       KA+ TLGI++G F V WLPFF+ 
Sbjct: 288 ALNGIVKLQKEVEECANLSRL-LKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLL 346

Query: 288 N-----IVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPR 342
           +     I    C CI   +     WLGY NS +NP IY  F RD +      L C     
Sbjct: 347 STARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNI 406

Query: 343 ERQASLAS--PSLRTSHSGPRP 362
            R+ S A    +L+ +    RP
Sbjct: 407 NRKLSAAGMHEALKLAERPERP 428


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score =  174 bits (440), Expect = 2e-43
 Identities = 108/317 (34%), Positives = 161/317 (50%), Gaps = 25/317 (7%)

Query: 33  LCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGR 91
           L  VI +    N L++  +C    LR   +N+F+VSL  +DL+V ++VMP   +  +   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 92  WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI-LSPLRYKLRMTPLRALALVLGA 150
           W+     CL+ T+ DV+  +ASI +LC ISLDRY  I   PL Y+ +MTPLR   ++ G 
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 151 WSLAALASFLPLLLGWHELG---------HARPPVPGQCRLLASLPFVLVASGLTFFLPS 201
           W +    SFLP++ GW+ +G           +      C  + + P+ +  S + F++P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 202 GAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSR 261
             +   Y RI + A++ A Q+  L    AS  S         RP  +SAD    +T   R
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES---------RP--QSADQH--STHRMR 252

Query: 262 KALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIY 320
              KA+ TL I++G F + W PFFV NIV    D   PG ++    WLGY NS +NP +Y
Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312

Query: 321 PLFMRDFKRALGRFLPC 337
               + F+RA    L C
Sbjct: 313 AFLNKSFRRAFLIILCC 329


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score =  174 bits (440), Expect = 2e-43
 Identities = 108/317 (34%), Positives = 161/317 (50%), Gaps = 25/317 (7%)

Query: 33  LCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGR 91
           L  VI +    N L++  +C    LR   +N+F+VSL  +DL+V ++VMP   +  +   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 92  WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI-LSPLRYKLRMTPLRALALVLGA 150
           W+     CL+ T+ DV+  +ASI +LC ISLDRY  I   PL Y+ +MTPLR   ++ G 
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 151 WSLAALASFLPLLLGWHELG---------HARPPVPGQCRLLASLPFVLVASGLTFFLPS 201
           W +    SFLP++ GW+ +G           +      C  + + P+ +  S + F++P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 202 GAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSR 261
             +   Y RI + A++ A Q+  L    AS  S         RP  +SAD    +T   R
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES---------RP--QSADQH--STHRMR 252

Query: 262 KALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIY 320
              KA+ TL I++G F + W PFFV NIV    D   PG ++    WLGY NS +NP +Y
Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312

Query: 321 PLFMRDFKRALGRFLPC 337
               + F+RA    L C
Sbjct: 313 AFLNKSFRRAFLIILCC 329


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score =  174 bits (440), Expect = 2e-43
 Identities = 108/317 (34%), Positives = 161/317 (50%), Gaps = 25/317 (7%)

Query: 33  LCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGR 91
           L  VI +    N L++  +C    LR   +N+F+VSL  +DL+V ++VMP   +  +   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 92  WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI-LSPLRYKLRMTPLRALALVLGA 150
           W+     CL+ T+ DV+  +ASI +LC ISLDRY  I   PL Y+ +MTPLR   ++ G 
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 151 WSLAALASFLPLLLGWHELG---------HARPPVPGQCRLLASLPFVLVASGLTFFLPS 201
           W +    SFLP++ GW+ +G           +      C  + + P+ +  S + F++P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 202 GAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSR 261
             +   Y RI + A++ A Q+  L    AS  S         RP  +SAD    +T   R
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES---------RP--QSADQH--STHRMR 252

Query: 262 KALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIY 320
              KA+ TL I++G F + W PFFV NIV    D   PG ++    WLGY NS +NP +Y
Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312

Query: 321 PLFMRDFKRALGRFLPC 337
               + F+RA    L C
Sbjct: 313 AFLNKSFRRAFLIILCC 329


>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
          Length = 387

 Score =  174 bits (440), Expect = 2e-43
 Identities = 108/317 (34%), Positives = 161/317 (50%), Gaps = 25/317 (7%)

Query: 33  LCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGR 91
           L  VI +    N L++  +C    LR   +N+F+VSL  +DL+V ++VMP   +  +   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 92  WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI-LSPLRYKLRMTPLRALALVLGA 150
           W+     CL+ T+ DV+  +ASI +LC ISLDRY  I   PL Y+ +MTPLR   ++ G 
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 151 WSLAALASFLPLLLGWHELG---------HARPPVPGQCRLLASLPFVLVASGLTFFLPS 201
           W +    SFLP++ GW+ +G           +      C  + + P+ +  S + F++P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 202 GAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSR 261
             +   Y RI + A++ A Q+  L    AS  S         RP  +SAD    +T   R
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES---------RP--QSADQH--STHRMR 252

Query: 262 KALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIY 320
              KA+ TL I++G F + W PFFV NIV    D   PG ++    WLGY NS +NP +Y
Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312

Query: 321 PLFMRDFKRALGRFLPC 337
               + F+RA    L C
Sbjct: 313 AFLNKSFRRAFLIILCC 329


>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
          Length = 378

 Score =  174 bits (440), Expect = 2e-43
 Identities = 108/317 (34%), Positives = 161/317 (50%), Gaps = 25/317 (7%)

Query: 33  LCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGR 91
           L  VI +    N L++  +C    LR   +N+F+VSL  +DL+V ++VMP   +  +   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 92  WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI-LSPLRYKLRMTPLRALALVLGA 150
           W+     CL+ T+ DV+  +ASI +LC ISLDRY  I   PL Y+ +MTPLR   ++ G 
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 151 WSLAALASFLPLLLGWHELG---------HARPPVPGQCRLLASLPFVLVASGLTFFLPS 201
           W +    SFLP++ GW+ +G           +      C  + + P+ +  S + F++P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 202 GAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSR 261
             +   Y RI + A++ A Q+  L    AS  S         RP  +SAD    +T   R
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES---------RP--QSADQH--STHRMR 252

Query: 262 KALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIY 320
              KA+ TL I++G F + W PFFV NIV    D   PG ++    WLGY NS +NP +Y
Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312

Query: 321 PLFMRDFKRALGRFLPC 337
               + F+RA    L C
Sbjct: 313 AFLNKSFRRAFLIILCC 329


>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
          Length = 388

 Score =  174 bits (440), Expect = 2e-43
 Identities = 108/317 (34%), Positives = 161/317 (50%), Gaps = 25/317 (7%)

Query: 33  LCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGR 91
           L  VI +    N L++  +C    LR   +N+F+VSL  +DL+V ++VMP   +  +   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 92  WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI-LSPLRYKLRMTPLRALALVLGA 150
           W+     CL+ T+ DV+  +ASI +LC ISLDRY  I   PL Y+ +MTPLR   ++ G 
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 151 WSLAALASFLPLLLGWHELG---------HARPPVPGQCRLLASLPFVLVASGLTFFLPS 201
           W +    SFLP++ GW+ +G           +      C  + + P+ +  S + F++P 
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205

Query: 202 GAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSR 261
             +   Y RI + A++ A Q+  L    AS  S         RP  +SAD    +T   R
Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES---------RP--QSADQH--STHRMR 252

Query: 262 KALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIY 320
              KA+ TL I++G F + W PFFV NIV    D   PG ++    WLGY NS +NP +Y
Sbjct: 253 TETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLY 312

Query: 321 PLFMRDFKRALGRFLPC 337
               + F+RA    L C
Sbjct: 313 AFLNKSFRRAFLIILCC 329


>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
           sapiens]
          Length = 471

 Score =  172 bits (436), Expect = 5e-43
 Identities = 106/326 (32%), Positives = 171/326 (52%), Gaps = 20/326 (6%)

Query: 28  WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNA 87
           W A    VVI LT A N L+I  +  +  L+N +N+FL+SL  +D+++G +VMP +ML  
Sbjct: 76  WSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTI 135

Query: 88  LYG-RWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALAL 146
           LYG RW L   LC +W   DV+  +ASI++LC ISLDRY+ I +P+ +    +  +A   
Sbjct: 136 LYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195

Query: 147 VLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICF 206
           ++  W+++   S    + G  +   ++    G C LLA   FVL+ S ++FF+P   +  
Sbjct: 196 IIAVWTISVGISMPIPVFGLQD--DSKVFKEGSC-LLADDNFVLIGSFVSFFIPLTIMVI 252

Query: 207 TYCRILLAARKQA----------VQVASLTTGMASQASETLQVPRTPRPGVESADSRRLA 256
           TY   + + +K+A           ++AS +    S  S      R+      S   RR  
Sbjct: 253 TYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTM 312

Query: 257 TKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVC-----DCISPGLFDVLTWLGYC 311
              S +  KA   LGI+  +F V W PFF+ NI+  +C     + +   L +V  W+GY 
Sbjct: 313 QSISNEQ-KACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYL 371

Query: 312 NSTMNPIIYPLFMRDFKRALGRFLPC 337
           +S +NP++Y LF + ++ A  R++ C
Sbjct: 372 SSAVNPLVYTLFNKTYRSAFSRYIQC 397


>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
          Length = 402

 Score =  170 bits (430), Expect = 3e-42
 Identities = 110/331 (33%), Positives = 163/331 (49%), Gaps = 39/331 (11%)

Query: 33  LCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGR 91
           L  VI +    N L++  +C    LR   +N+F+VSL  +DL+V ++VMP   +  +   
Sbjct: 26  LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI 85

Query: 92  WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLIL-SPLRYKLRMTPLRALALVLGA 150
           W+     CL+ T+ DV+  +ASI +LC ISLDRY  I   PL Y+ +MTPLR   ++ G 
Sbjct: 86  WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145

Query: 151 WSLAALASFLPLLLGWHELG----------------HA-------RPPVPGQCRLLASLP 187
           W +    SFLP++ GW+ +G                HA       +      C  + + P
Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQNSNSTYCVFMVNKP 205

Query: 188 FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGV 247
           + +  S + F++P   +   Y RI + A++ A Q+  L    AS  S         RP  
Sbjct: 206 YAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES---------RP-- 254

Query: 248 ESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLT 306
           +SAD    +T   R   KA+ TL I++G F + W PFFV NIV    D   PG ++    
Sbjct: 255 QSADQH--STHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL 312

Query: 307 WLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337
           WLGY NS +NP +Y    + F+RA    L C
Sbjct: 313 WLGYINSGLNPFLYAFLNKSFRRAFLIILCC 343


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  169 bits (429), Expect = 4e-42
 Identities = 106/325 (32%), Positives = 172/325 (52%), Gaps = 21/325 (6%)

Query: 36  VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLA 95
           +I      N L+I  +     L + +++++V+L  +DL++   V+P + +  + G W   
Sbjct: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95

Query: 96  RGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAA 155
           R  C +W A DV+CC+ASI+ LC+IS+DRY+ +  PLRY   +T  R L  +L  W+L+ 
Sbjct: 96  RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155

Query: 156 LASFLPLLLGWHELGHARPPVPGQ---CRLLASLPFVLVASGLTFFLPSGAICFTYCRIL 212
           + S  P L GW      R P P     C++     +VL ++  +F+LP   I   YCR+ 
Sbjct: 156 VISIGP-LFGW------RQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVY 208

Query: 213 LAARKQAVQVAS-LTTGMASQASETLQVPRTPRP-GVESADSRRLATKHSRKAL------ 264
           + A++++  + S L T  +     TL++ R   P G     S +  T  S + L      
Sbjct: 209 VVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREK 268

Query: 265 KASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPL 322
           KA+ TLGI++G F + WLPFF+   + +      P   +F ++ WLGY NS +NPIIYP 
Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC 328

Query: 323 FMRDFKRALGRFLPCPRCPRERQAS 347
             ++FK+A    L   +C   +Q+S
Sbjct: 329 SSQEFKKAFQNVLRI-QCLCRKQSS 352


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  169 bits (429), Expect = 4e-42
 Identities = 106/325 (32%), Positives = 172/325 (52%), Gaps = 21/325 (6%)

Query: 36  VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLA 95
           +I      N L+I  +     L + +++++V+L  +DL++   V+P + +  + G W   
Sbjct: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95

Query: 96  RGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAA 155
           R  C +W A DV+CC+ASI+ LC+IS+DRY+ +  PLRY   +T  R L  +L  W+L+ 
Sbjct: 96  RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155

Query: 156 LASFLPLLLGWHELGHARPPVPGQ---CRLLASLPFVLVASGLTFFLPSGAICFTYCRIL 212
           + S  P L GW      R P P     C++     +VL ++  +F+LP   I   YCR+ 
Sbjct: 156 VISIGP-LFGW------RQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVY 208

Query: 213 LAARKQAVQVAS-LTTGMASQASETLQVPRTPRP-GVESADSRRLATKHSRKAL------ 264
           + A++++  + S L T  +     TL++ R   P G     S +  T  S + L      
Sbjct: 209 VVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREK 268

Query: 265 KASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPL 322
           KA+ TLGI++G F + WLPFF+   + +      P   +F ++ WLGY NS +NPIIYP 
Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC 328

Query: 323 FMRDFKRALGRFLPCPRCPRERQAS 347
             ++FK+A    L   +C   +Q+S
Sbjct: 329 SSQEFKKAFQNVLRI-QCLCRKQSS 352


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  169 bits (429), Expect = 4e-42
 Identities = 106/325 (32%), Positives = 172/325 (52%), Gaps = 21/325 (6%)

Query: 36  VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLA 95
           +I      N L+I  +     L + +++++V+L  +DL++   V+P + +  + G W   
Sbjct: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95

Query: 96  RGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAA 155
           R  C +W A DV+CC+ASI+ LC+IS+DRY+ +  PLRY   +T  R L  +L  W+L+ 
Sbjct: 96  RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155

Query: 156 LASFLPLLLGWHELGHARPPVPGQ---CRLLASLPFVLVASGLTFFLPSGAICFTYCRIL 212
           + S  P L GW      R P P     C++     +VL ++  +F+LP   I   YCR+ 
Sbjct: 156 VISIGP-LFGW------RQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVY 208

Query: 213 LAARKQAVQVAS-LTTGMASQASETLQVPRTPRP-GVESADSRRLATKHSRKAL------ 264
           + A++++  + S L T  +     TL++ R   P G     S +  T  S + L      
Sbjct: 209 VVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREK 268

Query: 265 KASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPL 322
           KA+ TLGI++G F + WLPFF+   + +      P   +F ++ WLGY NS +NPIIYP 
Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC 328

Query: 323 FMRDFKRALGRFLPCPRCPRERQAS 347
             ++FK+A    L   +C   +Q+S
Sbjct: 329 SSQEFKKAFQNVLRI-QCLCRKQSS 352


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  169 bits (429), Expect = 4e-42
 Identities = 106/325 (32%), Positives = 172/325 (52%), Gaps = 21/325 (6%)

Query: 36  VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLA 95
           +I      N L+I  +     L + +++++V+L  +DL++   V+P + +  + G W   
Sbjct: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95

Query: 96  RGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAA 155
           R  C +W A DV+CC+ASI+ LC+IS+DRY+ +  PLRY   +T  R L  +L  W+L+ 
Sbjct: 96  RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155

Query: 156 LASFLPLLLGWHELGHARPPVPGQ---CRLLASLPFVLVASGLTFFLPSGAICFTYCRIL 212
           + S  P L GW      R P P     C++     +VL ++  +F+LP   I   YCR+ 
Sbjct: 156 VISIGP-LFGW------RQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVY 208

Query: 213 LAARKQAVQVAS-LTTGMASQASETLQVPRTPRP-GVESADSRRLATKHSRKAL------ 264
           + A++++  + S L T  +     TL++ R   P G     S +  T  S + L      
Sbjct: 209 VVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREK 268

Query: 265 KASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPL 322
           KA+ TLGI++G F + WLPFF+   + +      P   +F ++ WLGY NS +NPIIYP 
Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC 328

Query: 323 FMRDFKRALGRFLPCPRCPRERQAS 347
             ++FK+A    L   +C   +Q+S
Sbjct: 329 SSQEFKKAFQNVLRI-QCLCRKQSS 352


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  167 bits (422), Expect = 2e-41
 Identities = 107/338 (31%), Positives = 171/338 (50%), Gaps = 36/338 (10%)

Query: 29  VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
           +A  L V+   T  +N+ ++  I     L   +N+ + SL T+DL+V ++VMP ++   +
Sbjct: 41  LAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTI 100

Query: 89  YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVL 148
              W   + LC +W + D+ CC+ASIL+LC+I+LDRY  I   L Y  R T   A  ++ 
Sbjct: 101 THTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160

Query: 149 GAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTY 208
             W+++   S  PL   W +   A+  +       + + + + ++   F++PS  +   Y
Sbjct: 161 IVWAISICISIPPLF--WRQ-AKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217

Query: 209 CRILLAARKQAVQ----------VASLTTGMASQA----SETLQVPRTPRPG-------- 246
            RI  AAR + +            A L TG A  +    + +L    +   G        
Sbjct: 218 GRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHV 277

Query: 247 -VESADS----RRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVC--DC-IS 298
            ++ ADS    +R++    RKA K    LGI+LG F + WLPFFV ++V  +C   C I 
Sbjct: 278 KIKLADSALERKRISAARERKATK---ILGIILGAFIICWLPFFVVSLVLPICRDSCWIH 334

Query: 299 PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLP 336
           P LFD  TWLGY NS +NPIIY +F  +F++A  + +P
Sbjct: 335 PALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVP 372


>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
           sapiens]
          Length = 458

 Score =  166 bits (419), Expect = 5e-41
 Identities = 116/402 (28%), Positives = 193/402 (48%), Gaps = 50/402 (12%)

Query: 24  GGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPA 83
           G   W A ++ ++I +T   N L+I  +  +  L N +N+FL+SL  +D++VGL+VMP +
Sbjct: 51  GVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLS 110

Query: 84  MLNALYGR-WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLR 142
           +L  LY   W L R LC +W + DV+  +ASI++LC ISLDRY+ I +P+ +    +  +
Sbjct: 111 LLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTK 170

Query: 143 ALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSG 202
           A+  +   W+++   S    ++G  +    +  V     +L    FVL+ S + FF+P  
Sbjct: 171 AIMKIAIVWAISIGVSVPIPVIGLRD--EEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLT 228

Query: 203 AICFTYCRILLAARKQAVQVASLTTGMASQAS---------ETLQVPRTPRPGVESADSR 253
            +  TYC  +   R+QA+ +    T      S          T +   +  P  +  ++R
Sbjct: 229 IMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPN-QDQNAR 287

Query: 254 RLATKHSR---------KALKASLTLGILLGMFFVTWLPFFVANIVQAVCD--C---ISP 299
           R   K  R            KAS  LGI+  +F + W PFF+ NI+  +C+  C   +  
Sbjct: 288 RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLME 347

Query: 300 GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC----------PRCPRERQASLA 349
            L +V  W+GY  S +NP++Y LF + ++RA   +L C           + PR    +L+
Sbjct: 348 KLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALS 407

Query: 350 SPSLRTS------------HSGPRPGLSLQ-QVLPLPLPPDS 378
              L  +             S   PG+ +Q + L LP+ P S
Sbjct: 408 GRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSS 449


>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
          Length = 357

 Score =  165 bits (418), Expect = 7e-41
 Identities = 99/316 (31%), Positives = 160/316 (50%), Gaps = 16/316 (5%)

Query: 29  VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
           +   L  ++A T A N L++A I          +  + S+  SD++V  +VMP ++++ L
Sbjct: 43  ILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHEL 102

Query: 89  YGR-WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALV 147
            GR W L R LC LW A DV+CC+ASI N+  I+LDRY  I   + Y LR     +  ++
Sbjct: 103 SGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMI 162

Query: 148 LGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFT 207
              W+L+A+ S  PLL GW   G        +C++     + + ++   F+LP   + F 
Sbjct: 163 ALTWALSAVISLAPLLFGW---GETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFV 219

Query: 208 YCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLA--------TKH 259
           Y +I  AA+    +V S  T   S  SE ++V  + +        R           T  
Sbjct: 220 YWKIYKAAK---FRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWR 276

Query: 260 SRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLF-DVLTWLGYCNSTMNPI 318
            +K  +A+L +GIL+G+F + W+PFF+  ++  +C C  P ++  +  WLGY NS  NP+
Sbjct: 277 EQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPL 336

Query: 319 IYPLFMRDFKRALGRF 334
           IY  F +++  A   F
Sbjct: 337 IYTAFNKNYNSAFKNF 352


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  162 bits (409), Expect = 7e-40
 Identities = 95/301 (31%), Positives = 153/301 (50%), Gaps = 14/301 (4%)

Query: 28  WVAA---ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAM 84
           WV      + +++      N L+I  I     L+  +N+F+ SL  +DL++GL V+P   
Sbjct: 32  WVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGA 91

Query: 85  LNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRAL 144
            + L   W      C  WT+ DV+C +ASI  LC+I++DRY  I SP +Y+  +T  +A 
Sbjct: 92  AHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKAR 151

Query: 145 ALVLGAWSLAALASFLPLLLGWHELGHARP----PVPGQCRLLASLPFVLVASGLTFFLP 200
            ++L  W ++ L SFLP+ + W+   H            C    +  + + +S ++F++P
Sbjct: 152 VIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVP 211

Query: 201 SGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHS 260
              + F Y R+   A++Q +Q    + G         QV +  R G       R ++K  
Sbjct: 212 LVIMVFVYSRVFQEAKRQ-LQKIDKSEG-RFHVQNLSQVEQDGRTG----HGLRRSSKFC 265

Query: 261 RKALKASLTLGILLGMFFVTWLPFFVANIVQAVCD-CISPGLFDVLTWLGYCNSTMNPII 319
            K  KA  TLGI++G F + WLPFF+ NIV  + D  I   ++ +L W+GY NS  NP+I
Sbjct: 266 LKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLI 325

Query: 320 Y 320
           Y
Sbjct: 326 Y 326


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  160 bits (404), Expect = 3e-39
 Identities = 113/361 (31%), Positives = 177/361 (49%), Gaps = 45/361 (12%)

Query: 10  NSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLF 69
           NST A  A P +      + A + C +I      N L+   +  + AL+ T+N+ +VSL 
Sbjct: 19  NSTGASQARPHA------YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLA 72

Query: 70  TSDLMVGLVVMPPAM-LNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI 128
            +DL+V  +VMP  + L    G W  +R  C ++   DVM C+ASILNLC IS+DRY  +
Sbjct: 73  VADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV 132

Query: 129 LSPLRYK--LRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASL 186
           + P+ Y+     +  R +AL++ A  + A A   PLL G++  G      P  C  +++ 
Sbjct: 133 VMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGD-----PTVCS-ISNP 186

Query: 187 PFVLVASGLTFFLPSGAICFTYCRILLAAR---------KQAVQVASLTTGMASQASET- 236
            FV+ +S ++F+LP G     Y RI +  +         +Q  Q  S+  G   Q     
Sbjct: 187 DFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPD 246

Query: 237 ---LQVPR---------TPRPGVESADSRRLATKHSRKAL------KASLTLGILLGMFF 278
              L++ R            PG +         + +R +L      KA+  + I+LG F 
Sbjct: 247 PAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFI 306

Query: 279 VTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLP 336
           V WLPFF+ +++   C    +SP L+   TWLGY NS +NP+IY  F  +F++A  + L 
Sbjct: 307 VCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILS 366

Query: 337 C 337
           C
Sbjct: 367 C 367


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  158 bits (400), Expect = 8e-39
 Identities = 101/335 (30%), Positives = 158/335 (47%), Gaps = 38/335 (11%)

Query: 33  LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRW 92
           L ++   T  +N+ +IA +     L   +N+ + SL  +DL+V ++VMP + +  + GRW
Sbjct: 56  LALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRW 115

Query: 93  VLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWS 152
            L + +C  W + D+ CC+ASIL+LC+I+LDRY  I   + Y  + TP RA  ++   W 
Sbjct: 116 TLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWV 175

Query: 153 LAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRIL 212
            +   S  P    W +   A   V         + + + ++   F+ P+  +   Y RI 
Sbjct: 176 FSISISLPPFF--WRQ-AKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIY 232

Query: 213 LAAR------------KQAVQVASLTTGMASQASETLQVPRTPRPGVESA---------- 250
           + AR            K+  +   +T    S +S T    R P    ES           
Sbjct: 233 VEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKV 292

Query: 251 -------DSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCD---CISPG 300
                  + ++L     RKA K   TLGI+LG F V WLPFF+ ++V  +C         
Sbjct: 293 RVSDALLEKKKLMAARERKATK---TLGIILGAFIVCWLPFFIISLVMPICKDACWFHLA 349

Query: 301 LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFL 335
           +FD  TWLGY NS +NPIIY +   DFK+A  + +
Sbjct: 350 IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,395,692
Number of Sequences: 37866
Number of extensions: 980394
Number of successful extensions: 8318
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 568
Number of HSP's successfully gapped in prelim test: 255
Number of HSP's that attempted gapping in prelim test: 6735
Number of HSP's gapped (non-prelim): 1343
length of query: 440
length of database: 18,247,518
effective HSP length: 105
effective length of query: 335
effective length of database: 14,271,588
effective search space: 4780981980
effective search space used: 4780981980
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.