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Search of human proteins with 4504541
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
(458 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 916 0.0
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 425 e-119
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 360 2e-99
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 183 3e-46
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 182 4e-46
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 181 9e-46
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 179 4e-45
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 177 1e-44
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 173 3e-43
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 171 1e-42
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 171 1e-42
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 171 1e-42
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 171 1e-42
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 171 1e-42
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 170 2e-42
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 169 4e-42
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 168 8e-42
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 166 5e-41
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 165 9e-41
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 163 3e-40
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 163 3e-40
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 163 3e-40
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 163 3e-40
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 163 3e-40
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 161 1e-39
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 159 7e-39
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 159 7e-39
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 159 7e-39
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 158 1e-38
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 157 2e-38
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 916 bits (2368), Expect = 0.0
Identities = 458/458 (100%), Positives = 458/458 (100%)
Query: 1 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI 60
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
Sbjct: 1 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI 60
Query: 61 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW 120
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
Sbjct: 61 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW 120
Query: 121 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA 180
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
Sbjct: 121 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA 180
Query: 181 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV 240
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
Sbjct: 181 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV 240
Query: 241 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM 300
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
Sbjct: 241 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM 300
Query: 301 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC 360
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
Sbjct: 301 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC 360
Query: 361 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN 420
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
Sbjct: 361 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN 420
Query: 421 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV 458
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
Sbjct: 421 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV 458
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 425 bits (1092), Expect = e-119
Identities = 226/408 (55%), Positives = 289/408 (70%), Gaps = 12/408 (2%)
Query: 53 QNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLL 112
+NW AL ++II+TI GNILVIMAVS+EKKL NATNYFLMSLAIADML+G LVMP+S+L
Sbjct: 74 KNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSML 133
Query: 113 AILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAI 172
ILY Y WPLP LC VWI LDVLFSTASIMHLCAISLDRYVAI+NPI HSRFNSRTKA
Sbjct: 134 TILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF 193
Query: 173 MKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVI 232
+KI VW IS+G+S+PIPV GL+D+ KVF +C+L D NFVLIGSFV+FFIPLTIMVI
Sbjct: 194 LKIIAVWTISVGISMPIPVFGLQDDSKVF-KEGSCLLADDNFVLIGSFVSFFIPLTIMVI 252
Query: 233 TYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKK 292
TY LTI L+++A + + S FL + + ++ Q + R+
Sbjct: 253 TYFLTIKSLQKEATLCVSDLGTRAKLASFSFL--------PQSSLSSEKLFQRSIHREPG 304
Query: 293 ERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNV 352
R TMQ+I+NE+KA KVLGIVFF+F++MWCPFFITNI++V+C++SCN+ ++ LLNV
Sbjct: 305 SYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNV 364
Query: 353 FVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELN 412
FVWIGY+ S +NPLVYTLFNK YR AFS Y++C YK E K P++ I AL+ +
Sbjct: 365 FVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYK-ENKKPLQLILVNTIPALAYKSSQ 423
Query: 413 VNIYRHTNEPVIEKASDNEPGIEM--QVENLELPVNPSSVVSERISSV 458
+ + + N K +DN+ + + + E + S V+E++S V
Sbjct: 424 LQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV 471
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 360 bits (923), Expect = 2e-99
Identities = 185/353 (52%), Positives = 250/353 (70%), Gaps = 19/353 (5%)
Query: 54 NWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLA 113
+W AL I+++II TIGGN LVI+AVS+EKKL ATNYFLMSLA+AD+LVGL VMP++LL
Sbjct: 55 HWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLT 114
Query: 114 ILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIM 173
I+++ +WPLP LCP W+ LDVLFSTASIMHLCAIS+DRY+AI+ PI+ +++NSR A +
Sbjct: 115 IMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFI 174
Query: 174 KIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDP---NFVLIGSFVAFFIPLTIM 230
KI +VW ISIG+++P+P+ G+ + + NN TCVL +F+L GS AFF PL IM
Sbjct: 175 KITVVWLISIGIAIPVPIKGI-ETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIM 233
Query: 231 VITYCLTIYVLRRQALMLLHGHTEEPPGLSL------DFLKCCKRN-----TAEEENSAN 279
++TY LTI+ L+++A ++ + + L++ D C ++ A
Sbjct: 234 IVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKAL 293
Query: 280 PNQ-DQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCE 338
PN D+ RR + ++Q I+NE++ASKVLGIVFF+FL+MWCPFFITNI VLC+
Sbjct: 294 PNSGDETLMRRTSTIGKK--SVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCD 351
Query: 339 KSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEK 391
SCNQ ++ LL +FVWIGYV SG+NPLVYTLFNK +R AF Y+ CNY+ K
Sbjct: 352 -SCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATK 403
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 183 bits (464), Expect = 3e-46
Identities = 118/355 (33%), Positives = 195/355 (54%), Gaps = 43/355 (12%)
Query: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
+L++ + +MT N LVI A+ + +KLH+ NY + SLA+ D LV +LVMP S++ I+
Sbjct: 27 SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVR 86
Query: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIA 176
+ W + + +C +W+S+D+ T SI+HL AI+LDRY AI + +E++R + A + I
Sbjct: 87 ES-WIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIT 145
Query: 177 IVWAISIGVSVPIPVI-----GLRDEEKVFVNNTTCVLNDPNFV--LIGSFVAFFIPLTI 229
IVW IS+ +S+P P+ RD+E C++ + V + +F AF+IPL +
Sbjct: 146 IVWIISVFISMP-PLFWRHQGTSRDDE--------CIIKHDHIVSTIYSTFGAFYIPLAL 196
Query: 230 MVITYCLTIYVLRRQALMLLHGH------TEEPPGLSL-----DFLKCCKRNTAEEENSA 278
++I Y Y + R A L H EE G L K + E++ +
Sbjct: 197 ILILY----YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLS 252
Query: 279 NPNQD--------QNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFIT 330
+P+ D ++ R K E+ R + ERKA+ LG++ F+I W PFF+
Sbjct: 253 DPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVK 312
Query: 331 NILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
++ +C+K K+ E++ N W+GY+ S INPL+YT+FN+ +++AF +RC
Sbjct: 313 ELVVNVCDKC---KISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRC 364
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 182 bits (463), Expect = 4e-46
Identities = 115/344 (33%), Positives = 185/344 (53%), Gaps = 25/344 (7%)
Query: 58 LSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYD 117
+++V+I +T N+ VIMA+ KKLH NY + SLA+ D+LV +LVMPLS++ I+ D
Sbjct: 27 MTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMD 86
Query: 118 YVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAI 177
W L +LC VW+S+D+ T SI+HLC I+LDRY AI N IE++R + +A + I
Sbjct: 87 R-WKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILT 145
Query: 178 VWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPN--FVLIGSFVAFFIPLTIMVITYC 235
VW ISI +S +P + R ++ + C + + + + + AF+IPLT+++I Y
Sbjct: 146 VWTISIFIS--MPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYY 203
Query: 236 LTIYVLRRQALMLLHGHTEEPPGLSLD----FLKCCKRNTAEEENSANPNQDQNARRRKK 291
+ + +L G + S D F C T + + + +
Sbjct: 204 RIYHAAK--SLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHA 261
Query: 292 KERRP--------RGTMQAINN--ERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSC 341
R P G Q I++ ERKA+++LG++ F++ W PFFI ++ L +
Sbjct: 262 SIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTV 321
Query: 342 NQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
+ ++ + L W+GYV S INPL+YT FN+ ++ AF +RC
Sbjct: 322 SSEVADFL----TWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 181 bits (460), Expect = 9e-46
Identities = 113/344 (32%), Positives = 191/344 (55%), Gaps = 24/344 (6%)
Query: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
ALS +I+ + GN LV MAV E+ L TNY ++SLA+AD+LV LVMP + +
Sbjct: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
Query: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRT---KAIM 173
VW R C V+++LDV+ TASI++LCAIS+DRY A+ P+ + ++ + +
Sbjct: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152
Query: 174 KIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVIT 233
I VW ++ VS P+ + G + T C +++P+FV+ S V+F++P + V+
Sbjct: 153 MITAVWVLAFAVSCPL-LFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLV 207
Query: 234 YCLTIYVL--RRQALMLLHGHTE---EPPG-----LSLD--FLKCCKRNTAEEENSANPN 281
Y VL RR+ +L +++ PG LS D L+ + + ++ +
Sbjct: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
Query: 282 QDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSC 341
Q K+E + R ++ + E+KA++++ IV F++ W PFF+T++L+ C+ +C
Sbjct: 268 GFQERGGELKREEKTRNSLMPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TC 325
Query: 342 NQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
+ + +L + W+GYV S +NP++YT FN +R+AF L C
Sbjct: 326 H--VSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 179 bits (455), Expect = 4e-45
Identities = 114/351 (32%), Positives = 184/351 (52%), Gaps = 22/351 (6%)
Query: 64 IIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLP 123
I+ I GNILVI++V+ + L TNYF+++LA+AD+L+ V+P S + Y W L
Sbjct: 56 ILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGY-WVLG 114
Query: 124 RYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISI 183
R C +W ++DVL TASI+ LCAIS+DRY+ +R +++ +R KAI+ + VW +S
Sbjct: 115 RIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLST 174
Query: 184 GVSVPIPVIGLRDEEKVFVNNTTC-VLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLR 242
+S+ P++G + E ++ C V +P + L S +F+IPL ++++ YC V +
Sbjct: 175 VISIG-PLLGWK--EPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAK 231
Query: 243 RQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQA 302
R L G +E L+ +N E+ S+ K K PR ++
Sbjct: 232 RTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSST----------KAKGHNPRSSIAV 281
Query: 303 ----INNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGY 358
+ E+KA+K LGIV +F++ W PFFI L L K + + V W+GY
Sbjct: 282 KLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS---TLKPPDAVFKVVFWLGY 338
Query: 359 VCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGR 409
S +NP++Y +K ++RAF L C + + R+ R+ A + R
Sbjct: 339 FNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYR 389
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 177 bits (450), Expect = 1e-44
Identities = 108/330 (32%), Positives = 179/330 (54%), Gaps = 11/330 (3%)
Query: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
A+ + +I + T+ N V+ + + +KLH NY + SLA D+LV +LVMP+S+ A
Sbjct: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISI-AYTI 100
Query: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIA 176
+ W + LC +W+S D+ TASI+HLC I+LDRY AI + +E+S+ + A IA
Sbjct: 101 THTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160
Query: 177 IVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCL 236
IVWAISI +S+P P+ + + + +++ + ++ + + AF+IP +++I Y
Sbjct: 161 IVWAISICISIP-PLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGR 219
Query: 237 TIYVLRRQAL--MLLHGHTEEPPGLSLDFL--KCCKRNTAEEE---NSANPNQDQNARRR 289
R + L L+G L C N++ E +SA N +
Sbjct: 220 IYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKI 279
Query: 290 KKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKL 349
K + + ERKA+K+LGI+ F+I W PFF+ +++ +C SC + L
Sbjct: 280 KLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSC--WIHPAL 337
Query: 350 LNVFVWIGYVCSGINPLVYTLFNKIYRRAF 379
+ F W+GY+ S INP++YT+FN+ +R+AF
Sbjct: 338 FDFFTWLGYLNSLINPIIYTVFNEEFRQAF 367
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 173 bits (439), Expect = 3e-43
Identities = 112/387 (28%), Positives = 187/387 (48%), Gaps = 63/387 (16%)
Query: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
+L + +I + GN V+ A+++E+ L N NY + SLA+ D++V +LV+P+ A LY
Sbjct: 40 SLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPM---AALY 96
Query: 117 DYV--WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMK 174
+ W L + C ++I+LDVL T+SI+HLCAI+LDRY AI +PI++ + +A
Sbjct: 97 QVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAAL 156
Query: 175 IAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITY 234
I++ W I +S+P P++G R E + + D + + +F AF+IPL +M++ Y
Sbjct: 157 ISLTWLIGFLISIP-PMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLY 215
Query: 235 -----------CLTIYVLRRQALMLLHGHTEEP--------------------------- 256
T+ + + HG + P
Sbjct: 216 GRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGAL 275
Query: 257 ----------PGLSLDFLKCCKRNTAEEE----NSANPNQDQNARRRKKKERRPRGTMQ- 301
G +L+ ++ + ++E + A P A +K ER +
Sbjct: 276 CANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKM 335
Query: 302 AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFV-WIGYVC 360
A+ ERK K LGI+ F++ W PFFI ++ CE SC+ M LL + W+GY
Sbjct: 336 ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCH---MPTLLGAIINWLGYSN 392
Query: 361 SGINPLVYTLFNKIYRRAFSNYLRCNY 387
S +NP++Y FNK ++ AF ++C +
Sbjct: 393 SLLNPVIYAYFNKDFQNAFKKIIKCKF 419
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 171 bits (434), Expect = 1e-42
Identities = 99/323 (30%), Positives = 179/323 (55%), Gaps = 17/323 (5%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPL 122
+I+ + GNILVI++V+ + LH+ T+Y++++LA+AD+L+ V+P S + + Y W
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAF 94
Query: 123 PRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAIS 182
R C +W ++DVL TASIM LC IS+DRY+ + P+ + ++ + +M + VWA+S
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALS 154
Query: 183 IGVSVPIPVIGLRDEEKVFVNNTTCVLN-DPNFVLIGSFVAFFIPLTIMVITYCLTIYVL 241
+ +S+ P+ G R + + T C +N +P +VL + +F++PL I+++ YC V
Sbjct: 155 LVISIG-PLFGWR--QPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
Query: 242 RRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQ 301
+R++ L G + L+ ++N A + +A+ + R +
Sbjct: 212 KRESRGLKSGLKTDKSDSEQVTLRIHRKNA-----PAGGSGMASAKTKTHFSVR----LL 262
Query: 302 AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCS 361
+ E+KA+K LGIV F++ W PFF+ + + K E + + W+GY+ S
Sbjct: 263 KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP---DFKPSETVFKIVFWLGYLNS 319
Query: 362 GINPLVYTLFNKIYRRAFSNYLR 384
INP++Y ++ +++AF N LR
Sbjct: 320 CINPIIYPCSSQEFKKAFQNVLR 342
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 171 bits (434), Expect = 1e-42
Identities = 99/323 (30%), Positives = 179/323 (55%), Gaps = 17/323 (5%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPL 122
+I+ + GNILVI++V+ + LH+ T+Y++++LA+AD+L+ V+P S + + Y W
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAF 94
Query: 123 PRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAIS 182
R C +W ++DVL TASIM LC IS+DRY+ + P+ + ++ + +M + VWA+S
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALS 154
Query: 183 IGVSVPIPVIGLRDEEKVFVNNTTCVLN-DPNFVLIGSFVAFFIPLTIMVITYCLTIYVL 241
+ +S+ P+ G R + + T C +N +P +VL + +F++PL I+++ YC V
Sbjct: 155 LVISIG-PLFGWR--QPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
Query: 242 RRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQ 301
+R++ L G + L+ ++N A + +A+ + R +
Sbjct: 212 KRESRGLKSGLKTDKSDSEQVTLRIHRKNA-----PAGGSGMASAKTKTHFSVR----LL 262
Query: 302 AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCS 361
+ E+KA+K LGIV F++ W PFF+ + + K E + + W+GY+ S
Sbjct: 263 KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP---DFKPSETVFKIVFWLGYLNS 319
Query: 362 GINPLVYTLFNKIYRRAFSNYLR 384
INP++Y ++ +++AF N LR
Sbjct: 320 CINPIIYPCSSQEFKKAFQNVLR 342
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 171 bits (434), Expect = 1e-42
Identities = 99/323 (30%), Positives = 179/323 (55%), Gaps = 17/323 (5%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPL 122
+I+ + GNILVI++V+ + LH+ T+Y++++LA+AD+L+ V+P S + + Y W
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAF 94
Query: 123 PRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAIS 182
R C +W ++DVL TASIM LC IS+DRY+ + P+ + ++ + +M + VWA+S
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALS 154
Query: 183 IGVSVPIPVIGLRDEEKVFVNNTTCVLN-DPNFVLIGSFVAFFIPLTIMVITYCLTIYVL 241
+ +S+ P+ G R + + T C +N +P +VL + +F++PL I+++ YC V
Sbjct: 155 LVISIG-PLFGWR--QPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
Query: 242 RRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQ 301
+R++ L G + L+ ++N A + +A+ + R +
Sbjct: 212 KRESRGLKSGLKTDKSDSEQVTLRIHRKNA-----PAGGSGMASAKTKTHFSVR----LL 262
Query: 302 AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCS 361
+ E+KA+K LGIV F++ W PFF+ + + K E + + W+GY+ S
Sbjct: 263 KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP---DFKPSETVFKIVFWLGYLNS 319
Query: 362 GINPLVYTLFNKIYRRAFSNYLR 384
INP++Y ++ +++AF N LR
Sbjct: 320 CINPIIYPCSSQEFKKAFQNVLR 342
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 171 bits (434), Expect = 1e-42
Identities = 99/323 (30%), Positives = 179/323 (55%), Gaps = 17/323 (5%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPL 122
+I+ + GNILVI++V+ + LH+ T+Y++++LA+AD+L+ V+P S + + Y W
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAF 94
Query: 123 PRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAIS 182
R C +W ++DVL TASIM LC IS+DRY+ + P+ + ++ + +M + VWA+S
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALS 154
Query: 183 IGVSVPIPVIGLRDEEKVFVNNTTCVLN-DPNFVLIGSFVAFFIPLTIMVITYCLTIYVL 241
+ +S+ P+ G R + + T C +N +P +VL + +F++PL I+++ YC V
Sbjct: 155 LVISIG-PLFGWR--QPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
Query: 242 RRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQ 301
+R++ L G + L+ ++N A + +A+ + R +
Sbjct: 212 KRESRGLKSGLKTDKSDSEQVTLRIHRKNA-----PAGGSGMASAKTKTHFSVR----LL 262
Query: 302 AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCS 361
+ E+KA+K LGIV F++ W PFF+ + + K E + + W+GY+ S
Sbjct: 263 KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP---DFKPSETVFKIVFWLGYLNS 319
Query: 362 GINPLVYTLFNKIYRRAFSNYLR 384
INP++Y ++ +++AF N LR
Sbjct: 320 CINPIIYPCSSQEFKKAFQNVLR 342
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 171 bits (434), Expect = 1e-42
Identities = 116/379 (30%), Positives = 190/379 (50%), Gaps = 61/379 (16%)
Query: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
ALS +I+ + GN LV MAV E+ L TNY ++SLA+AD+LV LVMP + +
Sbjct: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
Query: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRT---KAIM 173
VW R C V+++LDV+ TASI++LCAIS+DRY A+ P+ + ++ + +
Sbjct: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152
Query: 174 KIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVIT 233
I VW ++ VS P+ + G + T C +++P+FV+ S V+F++P + V+
Sbjct: 153 MITAVWVLAFAVSCPL-LFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLV 207
Query: 234 YCLTIYVL--RRQALMLLHGHTE---------------EPPGLSLDFLKCCKRNTA---- 272
Y VL RR+ +L +++ +P L L ++TA
Sbjct: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
Query: 273 ----------EEENSANPNQDQNARRRKKKERR----------------PRGTMQAINNE 306
EE + N A + + R+ PRG E
Sbjct: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPL---RE 324
Query: 307 RKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPL 366
+KA++++ IV F++ W PFF+T++L+ C+ +C+ + +L + W+GYV S +NP+
Sbjct: 325 KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TCH--VSPELYSATTWLGYVNSALNPV 381
Query: 367 VYTLFNKIYRRAFSNYLRC 385
+YT FN +R+AF L C
Sbjct: 382 IYTTFNIEFRKAFLKILSC 400
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 170 bits (431), Expect = 2e-42
Identities = 105/338 (31%), Positives = 175/338 (51%), Gaps = 19/338 (5%)
Query: 60 IVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV 119
+ I+M + GN+LVI++V+ + L TNYF+++LA+AD+L+ V+P S + +
Sbjct: 103 LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGF- 161
Query: 120 WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW 179
W R C VW ++DVL TASI+ LC IS+DRYV +R+ +++ + KA +A++W
Sbjct: 162 WAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLW 221
Query: 180 AISIGVSVPIPVIGLRDEEKVFVNNTTC-VLNDPNFVLIGSFVAFFIPLTIMVITYCLTI 238
+++ VSV P++G + E V + C + + + + S +F++P+ ++V+ YC
Sbjct: 222 VVALVVSVG-PLLGWK--EPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVY 278
Query: 239 YVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRG 298
V R L G E S L+ R A + A+ R K R
Sbjct: 279 VVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAH-------GMRSAKGHTFRS 331
Query: 299 TMQA----INNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFV 354
++ + E+KA+K L IV VF++ W PFF L L + K E + V
Sbjct: 332 SLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQ---LKPSEGVFKVIF 388
Query: 355 WIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKK 392
W+GY S +NPL+Y ++ ++RAF LRC + ++
Sbjct: 389 WLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 169 bits (429), Expect = 4e-42
Identities = 106/347 (30%), Positives = 177/347 (51%), Gaps = 26/347 (7%)
Query: 55 WPALSIVIIIIMTIG---GNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSL 111
W L ++++ ++T+ N VI V +KLH NY + SLA+ D+LV +LVMP+S
Sbjct: 48 WKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIST 107
Query: 112 LAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKA 171
+ + W L + +C W+S D+ TASI+HLC I+LDRY AI + +E+S + +A
Sbjct: 108 MYTVTGR-WTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRA 166
Query: 172 IMKIAIVWAISIGVSVPIPVI--GLRDEEKVFVNNTTCVLNDPN--FVLIGSFVAFFIPL 227
+ IA+VW SI +S+P P + EE+V + CV+N + + + + AF+ P
Sbjct: 167 AVMIALVWVFSISISLP-PFFWRQAKAEEEV----SECVVNTDHILYTVYSTVGAFYFPT 221
Query: 228 TIMVITYCLTIYVLRRQALMLLHGHT----------EEPPGLSLDFLKCCKRNTAEEENS 277
+++ Y R + L T + PG + R S
Sbjct: 222 LLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSES 281
Query: 278 ANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLC 337
+P + R + + A ERKA+K LGI+ F++ W PFFI +++ +C
Sbjct: 282 GSPVYVNQVKVRVSDALLEKKKLMAA-RERKATKTLGIILGAFIVCWLPFFIISLVMPIC 340
Query: 338 EKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLR 384
+ +C L + + F W+GY+ S INP++YT+ N+ +++AF +R
Sbjct: 341 KDACWFHL--AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIR 385
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 168 bits (426), Expect = 8e-42
Identities = 121/403 (30%), Positives = 198/403 (49%), Gaps = 65/403 (16%)
Query: 38 FNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAI 97
FN SDG K N+ A + ++I + + GN+LV MAVS EK L TNY ++SLA+
Sbjct: 22 FNGSDG---KADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAV 78
Query: 98 ADMLVGLLVMP-LSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI 156
AD+LV LVMP + L ++ + W R C ++++LDV+ TASI++LCAIS+DRY A+
Sbjct: 79 ADLLVATLVMPWVVYLEVVGE--WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAV 136
Query: 157 RNP-IEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEK---VFVNNTTCVLNDP 212
P + ++R++S+ + + I+IVW +S +S P+ + GL + ++ + N V +
Sbjct: 137 AMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPL-LFGLNNADQNECIIANPAFVVYSSI 195
Query: 213 NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEP--------PGLSLDFL 264
+ V + + I ++ V +++ H P L ++ L
Sbjct: 196 VSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEML 255
Query: 265 KCCKRNT-------------------------AEEENSANPNQDQNARRRKK-------- 291
+ ++ A P ++ +A+ K
Sbjct: 256 SSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQ 315
Query: 292 -----KERRPRGTMQ----AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCN 342
K R TM + E+KA+++L IV VF+I W PFFIT+IL++ C+ CN
Sbjct: 316 TMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD--CN 373
Query: 343 QKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
+ L + F W+GYV S +NP++YT FN +R+AF L C
Sbjct: 374 --IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 166 bits (419), Expect = 5e-41
Identities = 116/402 (28%), Positives = 193/402 (48%), Gaps = 50/402 (12%)
Query: 51 GVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLS 110
G W A ++ ++I +T N L+I + + L N +N+FL+SL +D++VGL+VMP +
Sbjct: 24 GGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPA 83
Query: 111 LLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTK 170
+L LY W L R LC +W + DV+ +ASI++LC ISLDRY+ I +P+ + + +
Sbjct: 84 MLNALYGR-WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLR 142
Query: 171 AIMKIAIVWAISIGVSVPIPVIGLRD--EEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLT 228
A+ + W+++ S ++G + + V +L FVL+ S + FF+P
Sbjct: 143 ALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSG 202
Query: 229 IMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPN-QDQNAR 287
+ TYC + R+QA+ + T S T + + P + ++R
Sbjct: 203 AICFTYCRILLAARKQAVQVASLTTGMASQAS---------ETLQVPRTPRPGVESADSR 253
Query: 288 RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLME 347
R K R KAS LGI+ +F + W PFF+ NI+ +C+ C +
Sbjct: 254 RLATKHSR---------KALKASLTLGILLGMFFVTWLPFFVANIVQAVCD--C---ISP 299
Query: 348 KLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALS 407
L +V W+GY S +NP++Y LF + ++RA +L C + PR +L+
Sbjct: 300 GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC----------PRCPRERQASLA 349
Query: 408 GRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSS 449
L + S PG+ +Q + L LP+ P S
Sbjct: 350 SPSLRTS------------HSGPRPGLSLQ-QVLPLPLPPDS 378
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 165 bits (417), Expect = 9e-41
Identities = 130/406 (32%), Positives = 210/406 (51%), Gaps = 65/406 (16%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNA-TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWP 121
+I+M I GN+LV++AV +++L TNYF++SLA AD+LV +LVMP + ++ D +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWI 87
Query: 122 LPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI-RNPIEHSRFNSRTKAIMKIAIVWA 180
C V SLDVL +TASI HLC ISLDRY AI P+ + + + + + W
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147
Query: 181 ISIGVSVPIPV------IGLRD--EEKVF---VNNTTCV--LNDPNFVLIGSFVAFFIPL 227
I +S +P+ IG+ D E++ F N+T CV +N P + + S VAF+IP
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKP-YAITCSVVAFYIPF 205
Query: 228 TIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNAR 287
+MV+ Y IYV ++ H H ++ +R A E S + DQ++
Sbjct: 206 LLMVLAY-YRIYVTAKE-----HAHQ----------IQMLQRAGASSE-SRPQSADQHST 248
Query: 288 RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLME 347
R + E KA+K L I+ F + W PFF+TNI+ + + +
Sbjct: 249 HR-------------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT----VPG 291
Query: 348 KLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPV-RQIPRVAATAL 406
++ F+W+GY+ SG+NP +Y NK +RRAF L C+ + ++P + Q + T +
Sbjct: 292 QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTI 351
Query: 407 SGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVS 452
+G + ++ R+T V+ + G ++E L + +P S+ S
Sbjct: 352 NG---STHVLRYT---VLHR------GHHQELEKLPIHNDPESLES 385
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 163 bits (412), Expect = 3e-40
Identities = 118/348 (33%), Positives = 184/348 (52%), Gaps = 52/348 (14%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNA-TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWP 121
+I+M I GN+LV++AV +++L TNYF++SLA AD+LV +LVMP + ++ D +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWI 87
Query: 122 LPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI-RNPIEHSRFNSRTKAIMKIAIVWA 180
C V SLDVL +TASI HLC ISLDRY AI P+ + + + + + W
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147
Query: 181 ISIGVSVPIPV------IGLRD--EEKVF---VNNTTCV--LNDPNFVLIGSFVAFFIPL 227
I +S +P+ IG+ D E++ F N+T CV +N P + + S VAF+IP
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKP-YAITCSVVAFYIPF 205
Query: 228 TIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNAR 287
+MV+ Y IYV ++ H H ++ +R A E S + DQ++
Sbjct: 206 LLMVLAY-YRIYVTAKE-----HAHQ----------IQMLQRAGASSE-SRPQSADQHST 248
Query: 288 RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLME 347
R + E KA+K L I+ F + W PFF+TNI+ + + +
Sbjct: 249 HR-------------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT----VPG 291
Query: 348 KLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPV 395
++ F+W+GY+ SG+NP +Y NK +RRAF L C+ + ++P +
Sbjct: 292 QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSI 339
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 163 bits (412), Expect = 3e-40
Identities = 118/348 (33%), Positives = 184/348 (52%), Gaps = 52/348 (14%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNA-TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWP 121
+I+M I GN+LV++AV +++L TNYF++SLA AD+LV +LVMP + ++ D +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWI 87
Query: 122 LPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI-RNPIEHSRFNSRTKAIMKIAIVWA 180
C V SLDVL +TASI HLC ISLDRY AI P+ + + + + + W
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147
Query: 181 ISIGVSVPIPV------IGLRD--EEKVF---VNNTTCV--LNDPNFVLIGSFVAFFIPL 227
I +S +P+ IG+ D E++ F N+T CV +N P + + S VAF+IP
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKP-YAITCSVVAFYIPF 205
Query: 228 TIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNAR 287
+MV+ Y IYV ++ H H ++ +R A E S + DQ++
Sbjct: 206 LLMVLAY-YRIYVTAKE-----HAHQ----------IQMLQRAGASSE-SRPQSADQHST 248
Query: 288 RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLME 347
R + E KA+K L I+ F + W PFF+TNI+ + + +
Sbjct: 249 HR-------------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT----VPG 291
Query: 348 KLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPV 395
++ F+W+GY+ SG+NP +Y NK +RRAF L C+ + ++P +
Sbjct: 292 QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSI 339
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 163 bits (412), Expect = 3e-40
Identities = 118/348 (33%), Positives = 184/348 (52%), Gaps = 52/348 (14%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNA-TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWP 121
+I+M I GN+LV++AV +++L TNYF++SLA AD+LV +LVMP + ++ D +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWI 87
Query: 122 LPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI-RNPIEHSRFNSRTKAIMKIAIVWA 180
C V SLDVL +TASI HLC ISLDRY AI P+ + + + + + W
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147
Query: 181 ISIGVSVPIPV------IGLRD--EEKVF---VNNTTCV--LNDPNFVLIGSFVAFFIPL 227
I +S +P+ IG+ D E++ F N+T CV +N P + + S VAF+IP
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKP-YAITCSVVAFYIPF 205
Query: 228 TIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNAR 287
+MV+ Y IYV ++ H H ++ +R A E S + DQ++
Sbjct: 206 LLMVLAY-YRIYVTAKE-----HAHQ----------IQMLQRAGASSE-SRPQSADQHST 248
Query: 288 RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLME 347
R + E KA+K L I+ F + W PFF+TNI+ + + +
Sbjct: 249 HR-------------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT----VPG 291
Query: 348 KLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPV 395
++ F+W+GY+ SG+NP +Y NK +RRAF L C+ + ++P +
Sbjct: 292 QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSI 339
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 163 bits (412), Expect = 3e-40
Identities = 118/348 (33%), Positives = 184/348 (52%), Gaps = 52/348 (14%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNA-TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWP 121
+I+M I GN+LV++AV +++L TNYF++SLA AD+LV +LVMP + ++ D +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWI 87
Query: 122 LPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI-RNPIEHSRFNSRTKAIMKIAIVWA 180
C V SLDVL +TASI HLC ISLDRY AI P+ + + + + + W
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147
Query: 181 ISIGVSVPIPV------IGLRD--EEKVF---VNNTTCV--LNDPNFVLIGSFVAFFIPL 227
I +S +P+ IG+ D E++ F N+T CV +N P + + S VAF+IP
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKP-YAITCSVVAFYIPF 205
Query: 228 TIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNAR 287
+MV+ Y IYV ++ H H ++ +R A E S + DQ++
Sbjct: 206 LLMVLAY-YRIYVTAKE-----HAHQ----------IQMLQRAGASSE-SRPQSADQHST 248
Query: 288 RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLME 347
R + E KA+K L I+ F + W PFF+TNI+ + + +
Sbjct: 249 HR-------------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT----VPG 291
Query: 348 KLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPV 395
++ F+W+GY+ SG+NP +Y NK +RRAF L C+ + ++P +
Sbjct: 292 QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSI 339
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 163 bits (412), Expect = 3e-40
Identities = 118/348 (33%), Positives = 184/348 (52%), Gaps = 52/348 (14%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNA-TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWP 121
+I+M I GN+LV++AV +++L TNYF++SLA AD+LV +LVMP + ++ D +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWI 87
Query: 122 LPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI-RNPIEHSRFNSRTKAIMKIAIVWA 180
C V SLDVL +TASI HLC ISLDRY AI P+ + + + + + W
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147
Query: 181 ISIGVSVPIPV------IGLRD--EEKVF---VNNTTCV--LNDPNFVLIGSFVAFFIPL 227
I +S +P+ IG+ D E++ F N+T CV +N P + + S VAF+IP
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKP-YAITCSVVAFYIPF 205
Query: 228 TIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNAR 287
+MV+ Y IYV ++ H H ++ +R A E S + DQ++
Sbjct: 206 LLMVLAY-YRIYVTAKE-----HAHQ----------IQMLQRAGASSE-SRPQSADQHST 248
Query: 288 RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLME 347
R + E KA+K L I+ F + W PFF+TNI+ + + +
Sbjct: 249 HR-------------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT----VPG 291
Query: 348 KLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPV 395
++ F+W+GY+ SG+NP +Y NK +RRAF L C+ + ++P +
Sbjct: 292 QVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSI 339
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 161 bits (408), Expect = 1e-39
Identities = 113/356 (31%), Positives = 182/356 (51%), Gaps = 26/356 (7%)
Query: 53 QNWPA---LSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPL 109
Q W A L + +I+++ + GN+LVI+A++ +L TN F+MSLA AD+++GLLV+P
Sbjct: 55 QQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPF 114
Query: 110 SLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRT 169
+++ W + C +W S+DVL TASI LC I+LDRY+AI +P + +R
Sbjct: 115 GATIVVWGR-WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRA 173
Query: 170 KAIMKIAIVWAISIGVS-VPIPVIGLR---DEEKVFVNNTTC--VLNDPNFVLIGSFVAF 223
+A + VWAIS VS +PI + R DE + N+ C + + + + S V+F
Sbjct: 174 RARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSF 233
Query: 224 FIPLTIMVITYCLTIYVLRRQALML------LHGHTEEPPGLSLDFLKCCKRNTAEEENS 277
++PL IM Y ++Q + G PP S + +
Sbjct: 234 YVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPA 293
Query: 278 ANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLC 337
A A R K R R + A+ E+KA K LGI+ VF + W PFF+ N++
Sbjct: 294 AAAATAPLANGRAGKRRPSR--LVAL-REQKALKTLGIIMGVFTLCWLPFFLANVV---- 346
Query: 338 EKSCNQKLM-EKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKK 392
K+ +++L+ ++L F W+GY S NP++Y + +R+AF L C + ++
Sbjct: 347 -KAFHRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCCARRAARR 400
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 159 bits (401), Expect = 7e-39
Identities = 104/332 (31%), Positives = 167/332 (50%), Gaps = 18/332 (5%)
Query: 60 IVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV 119
+ +I ++TI GN LV+++V KKL +NY ++SLA+AD+ V + VMP + L
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 120 WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHS-RFNSRTKAIMKIAIV 178
W + C V+I++DV+ TASIM LC IS+DRY+ I P+ + R N + A M I V
Sbjct: 148 WIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKM-ILSV 206
Query: 179 WAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTI 238
W +S +++P P+ G + V + + D + + + VAF+IP+++M+ Y
Sbjct: 207 WLLSASITLP-PLFGW--AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIY 263
Query: 239 YVLRRQALM-LLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPR 297
R+ A G P + K EE + N R K ER+
Sbjct: 264 KAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECA-------NLSRLLKHERK-- 314
Query: 298 GTMQAINNERKASKVLGIVFFVFLIMWCPFF-ITNILSVLCEKSCNQKLMEKLLNVFVWI 356
+ E+KA+ LGI+ F + W PFF ++ +C SC+ + + F+W+
Sbjct: 315 -NISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS-CIPLWVERTFLWL 372
Query: 357 GYVCSGINPLVYTLFNKIYRRAFSNYLRCNYK 388
GY S INP +Y FN+ R + + L+C Y+
Sbjct: 373 GYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 159 bits (401), Expect = 7e-39
Identities = 104/332 (31%), Positives = 167/332 (50%), Gaps = 18/332 (5%)
Query: 60 IVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV 119
+ +I ++TI GN LV+++V KKL +NY ++SLA+AD+ V + VMP + L
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 120 WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHS-RFNSRTKAIMKIAIV 178
W + C V+I++DV+ TASIM LC IS+DRY+ I P+ + R N + A M I V
Sbjct: 148 WIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKM-ILSV 206
Query: 179 WAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTI 238
W +S +++P P+ G + V + + D + + + VAF+IP+++M+ Y
Sbjct: 207 WLLSASITLP-PLFGW--AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIY 263
Query: 239 YVLRRQALM-LLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPR 297
R+ A G P + K EE + N R K ER+
Sbjct: 264 KAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECA-------NLSRLLKHERK-- 314
Query: 298 GTMQAINNERKASKVLGIVFFVFLIMWCPFF-ITNILSVLCEKSCNQKLMEKLLNVFVWI 356
+ E+KA+ LGI+ F + W PFF ++ +C SC+ + + F+W+
Sbjct: 315 -NISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS-CIPLWVERTFLWL 372
Query: 357 GYVCSGINPLVYTLFNKIYRRAFSNYLRCNYK 388
GY S INP +Y FN+ R + + L+C Y+
Sbjct: 373 GYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 159 bits (401), Expect = 7e-39
Identities = 104/332 (31%), Positives = 167/332 (50%), Gaps = 18/332 (5%)
Query: 60 IVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV 119
+ +I ++TI GN LV+++V KKL +NY ++SLA+AD+ V + VMP + L
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 120 WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHS-RFNSRTKAIMKIAIV 178
W + C V+I++DV+ TASIM LC IS+DRY+ I P+ + R N + A M I V
Sbjct: 148 WIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKM-ILSV 206
Query: 179 WAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTI 238
W +S +++P P+ G + V + + D + + + VAF+IP+++M+ Y
Sbjct: 207 WLLSASITLP-PLFGW--AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIY 263
Query: 239 YVLRRQALM-LLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPR 297
R+ A G P + K EE + N R K ER+
Sbjct: 264 KAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECA-------NLSRLLKHERK-- 314
Query: 298 GTMQAINNERKASKVLGIVFFVFLIMWCPFF-ITNILSVLCEKSCNQKLMEKLLNVFVWI 356
+ E+KA+ LGI+ F + W PFF ++ +C SC+ + + F+W+
Sbjct: 315 -NISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS-CIPLWVERTFLWL 372
Query: 357 GYVCSGINPLVYTLFNKIYRRAFSNYLRCNYK 388
GY S INP +Y FN+ R + + L+C Y+
Sbjct: 373 GYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 158 bits (399), Expect = 1e-38
Identities = 117/362 (32%), Positives = 182/362 (50%), Gaps = 66/362 (18%)
Query: 63 IIIMTIGGNILVIMAVSMEKKLHNA-TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWP 121
+I+M I GN+LV++AV +++L TNYF++SLA AD+LV +LVMP + ++ D +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWI 87
Query: 122 LPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI-RNPIEHSRFNSRTKAIMKIAIVWA 180
C V SLDVL +TASI HLC ISLDRY AI P+ + + + + + W
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWV 147
Query: 181 ISIGVSVPIPV------IGLRDEEKVF-------------------VNNTTCV--LNDPN 213
I +S +P+ IG+ D E+ N+T CV +N P
Sbjct: 148 IPTFISF-LPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQNSNSTYCVFMVNKP- 205
Query: 214 FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAE 273
+ + S VAF+IP +MV+ Y IYV ++ H H ++ +R A
Sbjct: 206 YAITCSVVAFYIPFLLMVLAY-YRIYVTAKE-----HAHQ----------IQMLQRAGAS 249
Query: 274 EENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNIL 333
E S + DQ++ R + E KA+K L I+ F + W PFF+TNI+
Sbjct: 250 SE-SRPQSADQHSTHR-------------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIV 295
Query: 334 SVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKP 393
+ + + ++ F+W+GY+ SG+NP +Y NK +RRAF L C+ + ++P
Sbjct: 296 DPFIDYT----VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP 351
Query: 394 PV 395
+
Sbjct: 352 SI 353
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 157 bits (397), Expect = 2e-38
Identities = 105/337 (31%), Positives = 175/337 (51%), Gaps = 28/337 (8%)
Query: 56 PALSIVIIIIMTIGG---------NILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLV 106
P LS+ ++I+T+ G N+LV+ + + H + + S+A++D+LV LV
Sbjct: 34 PLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALV 93
Query: 107 MPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFN 166
MPLSL+ L W L R LC +WI+ DVL TASI ++ AI+LDRY +I +E++
Sbjct: 94 MPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRT 153
Query: 167 SRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTC-VLNDPNFVLIGSFVAFFI 225
+ + + IA+ WA+S +S+ + G E + C V +P++ + + AF++
Sbjct: 154 RKCVSNVMIALTWALSAVISLAPLLFGW--GETYSEGSEECQVSREPSYAVFSTVGAFYL 211
Query: 226 PLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQN 285
PL +++ Y IY + + ++ P E ++SA Q
Sbjct: 212 PLCVVLFVY-WKIYKAAKFRVGSRKTNSVSPIS-----------EAVEVKDSAKQPQMVF 259
Query: 286 ARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKL 345
R +P G E++A+ ++GI+ VF++ W PFF+T ++S LC SC+
Sbjct: 260 TVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLC--SCDIPA 317
Query: 346 MEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY 382
+ K ++F+W+GY S NPL+YT FNK Y AF N+
Sbjct: 318 IWK--SIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNF 352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.139 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,491,947
Number of Sequences: 37866
Number of extensions: 690755
Number of successful extensions: 4613
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 584
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 2673
Number of HSP's gapped (non-prelim): 1284
length of query: 458
length of database: 18,247,518
effective HSP length: 106
effective length of query: 352
effective length of database: 14,233,722
effective search space: 5010270144
effective search space used: 5010270144
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.