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Search of human proteins with 4504537
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
(365 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 736 0.0
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 397 e-111
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 323 1e-88
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 317 1e-86
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 248 5e-66
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 214 1e-55
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 214 1e-55
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 214 1e-55
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 206 3e-53
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 201 7e-52
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 201 7e-52
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 201 7e-52
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 201 7e-52
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 194 8e-50
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 186 3e-47
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 182 3e-46
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 181 9e-46
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 179 3e-45
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 177 1e-44
gi|4503383 dopamine receptor D1 [Homo sapiens] 176 3e-44
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 175 5e-44
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 175 5e-44
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 166 2e-41
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 160 1e-39
gi|4503391 dopamine receptor D5 [Homo sapiens] 158 6e-39
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 157 1e-38
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 157 2e-38
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 157 2e-38
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 153 2e-37
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 153 2e-37
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 736 bits (1899), Expect = 0.0
Identities = 365/365 (100%), Positives = 365/365 (100%)
Query: 1 MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYL 60
MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYL
Sbjct: 1 MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYL 60
Query: 61 ICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDR 120
ICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDR
Sbjct: 61 ICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDR 120
Query: 121 YWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHV 180
YWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHV
Sbjct: 121 YWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHV 180
Query: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240
IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ
Sbjct: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240
Query: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF
Sbjct: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
Query: 301 ILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIR 360
ILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIR
Sbjct: 301 ILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIR 360
Query: 361 CREHT 365
CREHT
Sbjct: 361 CREHT 365
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 397 bits (1020), Expect = e-111
Identities = 207/362 (57%), Positives = 260/362 (71%), Gaps = 10/362 (2%)
Query: 5 NCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSL 64
N T+E + P K+L+ +TL + +TT +N VI AI T+KLH PANYLICSL
Sbjct: 10 NLTSEELLNRMPS----KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSL 65
Query: 65 AVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAI 124
AVTD LVAVLVMP SI+YIV + W +G +C++WLSVD+TCCTCSILHL IALDRY AI
Sbjct: 66 AVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAI 125
Query: 125 TNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTI 184
T+A+EYARKRT K A +MI VW IS+FISMPPLFWR H+ S +C I+HDH++ TI
Sbjct: 126 TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWR-HQGTS-RDDECIIKHDHIVSTI 183
Query: 185 YSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLS---NRSTDSQNSFASCKLTQT 241
YST GAFYIPL LILILYY+IY AAK+LY KR +SR N ++ S K T
Sbjct: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243
Query: 242 FCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFI 301
V + S SDP+T+F+K H+++R + + RQ+IS TRERKAA LGLILGAF+
Sbjct: 244 SYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFV 303
Query: 302 LSWLPFFIKELIVGL-SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIR 360
+ WLPFF+KEL+V + +S E+++FL WLGY+NSLINPL+YT FNEDFK AF+KL+R
Sbjct: 304 ICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVR 363
Query: 361 CR 362
CR
Sbjct: 364 CR 365
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 323 bits (828), Expect = 1e-88
Identities = 178/366 (48%), Positives = 233/366 (63%), Gaps = 23/366 (6%)
Query: 8 TEASMAIRPKTITE-KMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAV 66
TE S A P+T+ K+ + + L VIT T L N V+ I T+KLH PANYLI SLA
Sbjct: 23 TETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLAT 82
Query: 67 TDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITN 126
TDLLV++LVMP+SI Y + W G LC++WLS D+TCCT SILHLCVIALDRYWAIT+
Sbjct: 83 TDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITD 142
Query: 127 AIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYS 186
A+EY+++RTA AA MI VW ISI IS+PPLFWR + S C + + YTIYS
Sbjct: 143 ALEYSKRRTAGHAATMIAIVWAISICISIPPLFWR-QAKAQEEMSDCLVNTSQISYTIYS 201
Query: 187 TLGAFYIPLTLILILYYRIYHAAK-------SLYQKRGSSRHLSNRSTDSQNSFASCKLT 239
T GAFYIP L++ILY RIY AA+ SLY KR ++ HL S S + C L
Sbjct: 202 TCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGS----SLCSLN 257
Query: 240 QTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGA 299
+ ++ F H I++ D ER++IS+ RERKA +ILG+ILGA
Sbjct: 258 SSLHEGHSHSAGSPLFFN--HVKIKL------ADSALERKRISAARERKATKILGIILGA 309
Query: 300 FILSWLPFFIKELIVGL--SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKK 357
FI+ WLPFF+ L++ + + + DF TWLGY+NSLINP++YT FNE+F+ AF+K
Sbjct: 310 FIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQK 369
Query: 358 LIRCRE 363
++ R+
Sbjct: 370 IVPFRK 375
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 317 bits (812), Expect = 1e-86
Identities = 174/362 (48%), Positives = 232/362 (64%), Gaps = 14/362 (3%)
Query: 5 NCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSL 64
NC+ + + ++ K+L+ M L +IT TTL N VI + T+KLH PANYLI SL
Sbjct: 32 NCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASL 91
Query: 65 AVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAI 124
AVTDLLV++LVMP+S +Y V RW LG +C+ WLS D+TCCT SILHLCVIALDRYWAI
Sbjct: 92 AVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAI 151
Query: 125 TNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTI 184
T+A+EY+ KRT KRAA+MI VW SI IS+PP FWR + S+C + DH++YT+
Sbjct: 152 TDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWR-QAKAEEEVSECVVNTDHILYTV 210
Query: 185 YSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCV 244
YST+GAFY P L++ LY RIY A+S K+ +R R T +Q + T V
Sbjct: 211 YSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNR-TGKRLTRAQ--LITDSPGSTSSV 267
Query: 245 SDFSTSDPTTEFEK----FHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
+ ++ P E + +++ D L E++++ + RERKA + LG+ILGAF
Sbjct: 268 TSINSRVPDVPSESGSPVYVNQVKVRVSDALL----EKKKLMAARERKATKTLGIILGAF 323
Query: 301 ILSWLPFFIKELIVGLSIYTVSSEVA--DFLTWLGYVNSLINPLLYTSFNEDFKLAFKKL 358
I+ WLPFFI L++ + +A DF TWLGY+NSLINP++YT NEDFK AF KL
Sbjct: 324 IVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL 383
Query: 359 IR 360
IR
Sbjct: 384 IR 385
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 248 bits (634), Expect = 5e-66
Identities = 147/389 (37%), Positives = 217/389 (55%), Gaps = 46/389 (11%)
Query: 18 TITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMP 77
T++ +++ + L + L N V+ AI + L ANYLI SLAVTDL+V+VLV+P
Sbjct: 32 TVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP 91
Query: 78 LSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAK 137
++ +Y V+++W LG C++++++D+ CCT SILHLC IALDRYWAIT+ I+Y KRT +
Sbjct: 92 MAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPR 151
Query: 138 RAALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLT 196
RAA +I W I IS+PP+ WR+ S P + CTI DH YTIYST GAFYIPL
Sbjct: 152 RAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDA-CTISKDHG-YTIYSTFGAFYIPLL 209
Query: 197 LILILYYRIYHAA--------KSLYQKRGSSRHLSNRSTDSQNSF------------ASC 236
L+L+LY RI+ AA K + + +RH ++ + + S
Sbjct: 210 LMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVES 269
Query: 237 KLTQTFCVS------DFSTSDPTTEFEKFHASIRIPPFDND----------LDHPGER-- 278
K C + D + E + S P ++ + ER
Sbjct: 270 KAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNA 329
Query: 279 ---QQISSTRERKAARILGLILGAFILSWLPFFIKELIVGL--SIYTVSSEVADFLTWLG 333
++++ RERK + LG+I+G FIL WLPFFI L++ S + + + + WLG
Sbjct: 330 EAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLG 389
Query: 334 YVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
Y NSL+NP++Y FN+DF+ AFKK+I+C+
Sbjct: 390 YSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 214 bits (544), Expect = 1e-55
Identities = 135/352 (38%), Positives = 192/352 (54%), Gaps = 39/352 (11%)
Query: 21 EKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMP-LS 79
EK++I L +IT LT N V++++ KKL QP+NYLI SLA+ DL VAV VMP +S
Sbjct: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139
Query: 80 IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRA 139
+ ++ +W G+F C V++++D+ CCT SI+ LCVI++DRY IT + Y ++ K
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 140 ALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLI 198
A MIL+VW +S I++PPLF W + C I D YTIYST AFYIP++++
Sbjct: 200 AKMILSVWLLSASITLPPLFGWAQNVN---DDKVCLISQDFG-YTIYSTAVAFYIPMSVM 255
Query: 199 LILYYRIYHAAKSLYQKR---GSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTE 255
L +YY+IY AA+ K G R + S + N + C +
Sbjct: 256 LFMYYQIYKAARKSAAKHKFPGFPR-VEPDSVIALNGIVKLQKEVEECAN---------- 304
Query: 256 FEKFHASIRIPPFDNDLDHPGERQQIS-STRERKAARILGLILGAFILSWLPFFI----K 310
L H ER+ IS RE+KAA LG+I+GAF + WLPFF+ +
Sbjct: 305 ------------LSRLLKH--ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR 350
Query: 311 ELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
I G S + V WLGY NSLINP +Y FN D + ++ L++C+
Sbjct: 351 PFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 214 bits (544), Expect = 1e-55
Identities = 135/352 (38%), Positives = 192/352 (54%), Gaps = 39/352 (11%)
Query: 21 EKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMP-LS 79
EK++I L +IT LT N V++++ KKL QP+NYLI SLA+ DL VAV VMP +S
Sbjct: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139
Query: 80 IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRA 139
+ ++ +W G+F C V++++D+ CCT SI+ LCVI++DRY IT + Y ++ K
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 140 ALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLI 198
A MIL+VW +S I++PPLF W + C I D YTIYST AFYIP++++
Sbjct: 200 AKMILSVWLLSASITLPPLFGWAQNVN---DDKVCLISQDFG-YTIYSTAVAFYIPMSVM 255
Query: 199 LILYYRIYHAAKSLYQKR---GSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTE 255
L +YY+IY AA+ K G R + S + N + C +
Sbjct: 256 LFMYYQIYKAARKSAAKHKFPGFPR-VEPDSVIALNGIVKLQKEVEECAN---------- 304
Query: 256 FEKFHASIRIPPFDNDLDHPGERQQIS-STRERKAARILGLILGAFILSWLPFFI----K 310
L H ER+ IS RE+KAA LG+I+GAF + WLPFF+ +
Sbjct: 305 ------------LSRLLKH--ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR 350
Query: 311 ELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
I G S + V WLGY NSLINP +Y FN D + ++ L++C+
Sbjct: 351 PFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 214 bits (544), Expect = 1e-55
Identities = 135/352 (38%), Positives = 192/352 (54%), Gaps = 39/352 (11%)
Query: 21 EKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMP-LS 79
EK++I L +IT LT N V++++ KKL QP+NYLI SLA+ DL VAV VMP +S
Sbjct: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139
Query: 80 IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRA 139
+ ++ +W G+F C V++++D+ CCT SI+ LCVI++DRY IT + Y ++ K
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 140 ALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLI 198
A MIL+VW +S I++PPLF W + C I D YTIYST AFYIP++++
Sbjct: 200 AKMILSVWLLSASITLPPLFGWAQNVN---DDKVCLISQDFG-YTIYSTAVAFYIPMSVM 255
Query: 199 LILYYRIYHAAKSLYQKR---GSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTE 255
L +YY+IY AA+ K G R + S + N + C +
Sbjct: 256 LFMYYQIYKAARKSAAKHKFPGFPR-VEPDSVIALNGIVKLQKEVEECAN---------- 304
Query: 256 FEKFHASIRIPPFDNDLDHPGERQQIS-STRERKAARILGLILGAFILSWLPFFI----K 310
L H ER+ IS RE+KAA LG+I+GAF + WLPFF+ +
Sbjct: 305 ------------LSRLLKH--ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR 350
Query: 311 ELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
I G S + V WLGY NSLINP +Y FN D + ++ L++C+
Sbjct: 351 PFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 206 bits (523), Expect = 3e-53
Identities = 118/343 (34%), Positives = 188/343 (54%), Gaps = 27/343 (7%)
Query: 23 MLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIY 82
+LI L + T NL V+ I + H+ + L+ S+AV+D+LVA LVMPLS+++
Sbjct: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
Query: 83 IVMDR-WKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAAL 141
+ R W+LG LC++W++ D+ CCT SI ++ IALDRYW+IT +EY + + +
Sbjct: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV 160
Query: 142 MILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILIL 201
MI W +S IS+ PL + S +C + + Y ++ST+GAFY+PL ++L +
Sbjct: 161 MIALTWALSAVISLAPLLFGWGETYSEGSEECQVSRE-PSYAVFSTVGAFYLPLCVVLFV 219
Query: 202 YYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHA 261
Y++IY AAK + +R T+S + +++ V D S P F HA
Sbjct: 220 YWKIYKAAKF---------RVGSRKTNSVS-----PISEAVEVKD-SAKQPQMVFTVRHA 264
Query: 262 SIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTV 321
++ P E +E++AA ++G+++G F+L W+PFF+ ELI L +
Sbjct: 265 TVTFQP---------EGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDI 315
Query: 322 SSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREH 364
+ WLGY NS NPL+YT+FN+++ AFK R+H
Sbjct: 316 PAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF-SRQH 357
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 201 bits (512), Expect = 7e-52
Identities = 123/370 (33%), Positives = 194/370 (52%), Gaps = 38/370 (10%)
Query: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63
+NCT + P I++ +L+ + L + L N+ VI+++ + LH +Y I +
Sbjct: 12 SNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVN 67
Query: 64 LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123
LAV DLL+ V+P S I+ V+ W G C +W +VD+ CCT SI+ LC+I++DRY
Sbjct: 68 LAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIG 127
Query: 124 ITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTI--QHDHV 180
++ + Y T +R + +L VW +S+ IS+ PLF WR P P TI ++
Sbjct: 128 VSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQINEEP 182
Query: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240
Y ++S LG+FY+PL +IL++Y R+Y AK + RG L +DS+
Sbjct: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKR--ESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Query: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
S T K H S+R+ F +RE+KAA+ LG+++G F
Sbjct: 241 APAGGSGMASAKT----KTHFSVRLLKF---------------SREKKAAKTLGIVVGCF 281
Query: 301 ILSWLPFFIKELIVG-LSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLI 359
+L WLPFF+ I + S V + WLGY+NS INP++Y +++FK AF+ ++
Sbjct: 282 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
Query: 360 R----CREHT 365
R CR+ +
Sbjct: 342 RIQCLCRKQS 351
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 201 bits (512), Expect = 7e-52
Identities = 123/370 (33%), Positives = 194/370 (52%), Gaps = 38/370 (10%)
Query: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63
+NCT + P I++ +L+ + L + L N+ VI+++ + LH +Y I +
Sbjct: 12 SNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVN 67
Query: 64 LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123
LAV DLL+ V+P S I+ V+ W G C +W +VD+ CCT SI+ LC+I++DRY
Sbjct: 68 LAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIG 127
Query: 124 ITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTI--QHDHV 180
++ + Y T +R + +L VW +S+ IS+ PLF WR P P TI ++
Sbjct: 128 VSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQINEEP 182
Query: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240
Y ++S LG+FY+PL +IL++Y R+Y AK + RG L +DS+
Sbjct: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKR--ESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Query: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
S T K H S+R+ F +RE+KAA+ LG+++G F
Sbjct: 241 APAGGSGMASAKT----KTHFSVRLLKF---------------SREKKAAKTLGIVVGCF 281
Query: 301 ILSWLPFFIKELIVG-LSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLI 359
+L WLPFF+ I + S V + WLGY+NS INP++Y +++FK AF+ ++
Sbjct: 282 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
Query: 360 R----CREHT 365
R CR+ +
Sbjct: 342 RIQCLCRKQS 351
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 201 bits (512), Expect = 7e-52
Identities = 123/370 (33%), Positives = 194/370 (52%), Gaps = 38/370 (10%)
Query: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63
+NCT + P I++ +L+ + L + L N+ VI+++ + LH +Y I +
Sbjct: 12 SNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVN 67
Query: 64 LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123
LAV DLL+ V+P S I+ V+ W G C +W +VD+ CCT SI+ LC+I++DRY
Sbjct: 68 LAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIG 127
Query: 124 ITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTI--QHDHV 180
++ + Y T +R + +L VW +S+ IS+ PLF WR P P TI ++
Sbjct: 128 VSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQINEEP 182
Query: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240
Y ++S LG+FY+PL +IL++Y R+Y AK + RG L +DS+
Sbjct: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKR--ESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Query: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
S T K H S+R+ F +RE+KAA+ LG+++G F
Sbjct: 241 APAGGSGMASAKT----KTHFSVRLLKF---------------SREKKAAKTLGIVVGCF 281
Query: 301 ILSWLPFFIKELIVG-LSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLI 359
+L WLPFF+ I + S V + WLGY+NS INP++Y +++FK AF+ ++
Sbjct: 282 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
Query: 360 R----CREHT 365
R CR+ +
Sbjct: 342 RIQCLCRKQS 351
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 201 bits (512), Expect = 7e-52
Identities = 123/370 (33%), Positives = 194/370 (52%), Gaps = 38/370 (10%)
Query: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63
+NCT + P I++ +L+ + L + L N+ VI+++ + LH +Y I +
Sbjct: 12 SNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVN 67
Query: 64 LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123
LAV DLL+ V+P S I+ V+ W G C +W +VD+ CCT SI+ LC+I++DRY
Sbjct: 68 LAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIG 127
Query: 124 ITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTI--QHDHV 180
++ + Y T +R + +L VW +S+ IS+ PLF WR P P TI ++
Sbjct: 128 VSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQINEEP 182
Query: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240
Y ++S LG+FY+PL +IL++Y R+Y AK + RG L +DS+
Sbjct: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKR--ESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Query: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
S T K H S+R+ F +RE+KAA+ LG+++G F
Sbjct: 241 APAGGSGMASAKT----KTHFSVRLLKF---------------SREKKAAKTLGIVVGCF 281
Query: 301 ILSWLPFFIKELIVG-LSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLI 359
+L WLPFF+ I + S V + WLGY+NS INP++Y +++FK AF+ ++
Sbjct: 282 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
Query: 360 R----CREHT 365
R CR+ +
Sbjct: 342 RIQCLCRKQS 351
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 194 bits (494), Expect = 8e-50
Identities = 120/366 (32%), Positives = 196/366 (53%), Gaps = 41/366 (11%)
Query: 8 TEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVT 67
T ++ + IT + + + L + N+ VI+++ + L P NY I +LA+
Sbjct: 31 TSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMA 90
Query: 68 DLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNA 127
DLL++ V+P S V+ W LG C++W +VD+ CCT SIL LC I++DRY + +
Sbjct: 91 DLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYS 150
Query: 128 IEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRLSPPPS---QCTIQHDHVIYT 183
++Y T ++A L +L+VW +S IS+ PL W+ P P+ +C + + Y
Sbjct: 151 LQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWK-----EPAPNDDKECGVT-EEPFYA 204
Query: 184 IYSTLGAFYIPLTLILILYYRIYHAAKSLYQ--KRGSSRHLSNRSTDSQNSFASCKLTQT 241
++S+LG+FYIPL +IL++Y R+Y AK + + G + +SN S +LT
Sbjct: 205 LFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSN----------SKELTLR 254
Query: 242 FCVSDFSTSDPTTEFEKFH---ASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILG 298
+F ++ K H +SI + F +RE+KAA+ LG+++G
Sbjct: 255 IHSKNFHEDTLSSTKAKGHNPRSSIAVKLF-------------KFSREKKAAKTLGIVVG 301
Query: 299 AFILSWLPFFIKELIVGLSIYTVSSEVADF--LTWLGYVNSLINPLLYTSFNEDFKLAFK 356
FIL WLPFFI L +G T+ A F + WLGY NS +NP++Y +++FK AF
Sbjct: 302 MFILCWLPFFI-ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV 360
Query: 357 KLIRCR 362
+++ C+
Sbjct: 361 RILGCQ 366
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 186 bits (472), Expect = 3e-47
Identities = 118/361 (32%), Positives = 183/361 (50%), Gaps = 50/361 (13%)
Query: 19 ITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPL 78
+ EK + V+ LT N+ VIMA+ KKL NY + SLA+ D+L+ LVMP+
Sbjct: 71 LQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130
Query: 79 SIIYIVMD-RWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAK 137
S++ I+ RW L LC VW+ +D+ T SI+HLC I+LDRY AI N I ++R +
Sbjct: 131 SMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRT 190
Query: 138 RAALMILTVWTISIFISMP-PLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLT 196
+A L I+ VWTIS+ ISMP P+F C + D+ + + + +F+IPLT
Sbjct: 191 KAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDN--FVLIGSFVSFFIPLT 248
Query: 197 LILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEF 256
+++I Y+ KSL ++ T CVSD T F
Sbjct: 249 IMVITYFL---TIKSLQKE------------------------ATLCVSDLGTRAKLASF 281
Query: 257 -----------EKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWL 305
+ F SI P + G R S + E+KA ++LG++ F++ W
Sbjct: 282 SFLPQSSLSSEKLFQRSIHREPG----SYTGRRTMQSISNEQKACKVLGIVFFLFVVMWC 337
Query: 306 PFFIKELIVGLSIYTVSSEVADFL----TWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
PFFI ++ + + + +V L W+GY++S +NPL+YT FN+ ++ AF + I+C
Sbjct: 338 PFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQC 397
Query: 362 R 362
+
Sbjct: 398 Q 398
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 182 bits (463), Expect = 3e-46
Identities = 115/344 (33%), Positives = 185/344 (53%), Gaps = 25/344 (7%)
Query: 27 MTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMD 86
+++V+I +T N+ VIMA+ KKLH NY + SLA+ D+LV +LVMPLS++ I+ D
Sbjct: 58 LSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYD 117
Query: 87 R-WKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILT 145
W L +LC VW+S+D+ T SI+HLC I+LDRY AI N IE++R + +A + I
Sbjct: 118 YVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAI 177
Query: 146 VWTISIFIS--MPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYY 203
VW ISI +S +P + R ++ + C + + + + + AF+IPLT+++I Y
Sbjct: 178 VWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPN--FVLIGSFVAFFIPLTIMVITYC 235
Query: 204 RIYHAAK--SLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHA 261
+ + +L G + S D F C T + + + +
Sbjct: 236 LTIYVLRRQALMLLHGHTEEPPGLSLD----FLKCCKRNTAEEENSANPNQDQNARRRKK 291
Query: 262 SIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTV 321
R P G Q I++ ERKA+++LG++ F++ W PFFI ++ L +
Sbjct: 292 KERRP--------RGTMQAINN--ERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSC 341
Query: 322 SSEVADFL----TWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
+ ++ + L W+GYV S INPL+YT FN+ ++ AF +RC
Sbjct: 342 NQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 181 bits (459), Expect = 9e-46
Identities = 119/351 (33%), Positives = 172/351 (49%), Gaps = 24/351 (6%)
Query: 20 TEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLS 79
T M + M L+V+ L N+ VI+AI T +L N I SLA DL++ +LV+P
Sbjct: 58 TAGMGLLMALIVL--LIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFG 115
Query: 80 IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRA 139
+V RW+ G F CE+W SVD+ C T SI LCVIALDRY AIT+ Y T RA
Sbjct: 116 ATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARA 175
Query: 140 ALMILTVWTISIFISMPPL---FWRSH----RRLSPPPSQCTIQHDHVIYTIYSTLGAFY 192
++ TVW IS +S P+ +WR+ RR P C + Y I S++ +FY
Sbjct: 176 RGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRA-YAIASSVVSFY 234
Query: 193 IPLTLILILYYRIYHAAKSLYQKRGS--SRHLSNRSTDSQNSFASCKLTQTFCVSDFSTS 250
+PL ++ +Y R++ A+ +K S R L + S S
Sbjct: 235 VPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPS-----------PSPVPAP 283
Query: 251 DPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIK 310
P + A+ P N ++ + RE+KA + LG+I+G F L WLPFF+
Sbjct: 284 APPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLA 343
Query: 311 ELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
++ V + F WLGY NS NP++Y + DF+ AF+ L+ C
Sbjct: 344 NVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCC 393
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 179 bits (454), Expect = 3e-45
Identities = 115/342 (33%), Positives = 183/342 (53%), Gaps = 41/342 (11%)
Query: 40 NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDR--WKLGYFLCEV 97
N V MA+ + L NYL+ SLAV DLLVA LVMP ++Y+ + W C+V
Sbjct: 47 NGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEVTGGVWNFSRICCDV 105
Query: 98 WLSVDMTCCTCSILHLCVIALDRYWAITNAIEYAR---KRTAKRAALMILTVWTISIFIS 154
++++D+ CT SIL+LC I++DRY A+ + Y + + +R ALMI VW ++ +S
Sbjct: 106 FVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS 165
Query: 155 MPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQ 214
P LF + + P+ C+I + + IYS++ +FY+P + +++Y RIY K +
Sbjct: 166 CPLLFGFN---TTGDPTVCSISNPD--FVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRR 220
Query: 215 KRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT-TEFEKFHASIRIPPFDNDLD 273
KR +R QNS C + + DP E +++++ + D L
Sbjct: 221 KRILTR---------QNS--QCNSVRPGFPQQTLSPDPAHLELKRYYSICQ----DTALG 265
Query: 274 HPG-------------ERQQISSTRERKAARILGLILGAFILSWLPFFIKELI-VGLSIY 319
PG R + RE+KA +++ ++LGAFI+ WLPFF+ ++
Sbjct: 266 GPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTC 325
Query: 320 TVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
VS E+ TWLGYVNS +NP++YT+FN +F+ AF K++ C
Sbjct: 326 HVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 177 bits (450), Expect = 1e-44
Identities = 118/382 (30%), Positives = 188/382 (49%), Gaps = 60/382 (15%)
Query: 34 TLTTLL-------NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMD 86
TL TLL N+ V MA+ K L NYLI SLAV DLLVA LVMP + V+
Sbjct: 39 TLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG 98
Query: 87 RWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEY-ARKRTAKRAALMILT 145
WK C++++++D+ CT SIL+LC I++DRY A+ + Y R + +R +MI
Sbjct: 99 EWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISI 158
Query: 146 VWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRI 205
VW +S IS P LF + + ++C I + + +YS++ +FY+P + L++Y +I
Sbjct: 159 VWVLSFTISCPLLFGLN----NADQNECIIANP--AFVVYSSIVSFYVPFIVTLLVYIKI 212
Query: 206 Y----HAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT--TEFEKF 259
Y K + KR S ++ + + + + +S S + T +
Sbjct: 213 YIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPS 272
Query: 260 HASIRIP-PFDNDL-----------------DHPG----------------------ERQ 279
H + +P P + L DHP R+
Sbjct: 273 HHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRR 332
Query: 280 QISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLI 339
++S +E+KA ++L ++LG FI+ WLPFFI ++ + + TWLGYVNS +
Sbjct: 333 KLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAV 392
Query: 340 NPLLYTSFNEDFKLAFKKLIRC 361
NP++YT+FN +F+ AF K++ C
Sbjct: 393 NPIIYTTFNIEFRKAFLKILHC 414
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 176 bits (446), Expect = 3e-44
Identities = 112/354 (31%), Positives = 176/354 (49%), Gaps = 55/354 (15%)
Query: 27 MTLVVITTL--TTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIV 84
++L++++TL TL+ AVI K+ N+ + SLAV+DLLVAVLVMP + +
Sbjct: 30 LSLLILSTLLGNTLVCAAVIRFRHLRSKV---TNFFVISLAVSDLLVAVLVMPWKAVAEI 86
Query: 85 MDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMIL 144
W G F C +W++ D+ C T SIL+LCVI++DRYWAI++ Y RK T K A ++I
Sbjct: 87 AGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILIS 145
Query: 145 TVWTISIFISMPP--LFWRSHRRLSPPPSQCTIQHDHV---------IYTIYSTLGAFYI 193
WT+S+ IS P L W + SP T + + Y I S++ +FYI
Sbjct: 146 VAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYI 205
Query: 194 PLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT 253
P+ ++++ Y RIY A+ ++ + + + + Q + + K + S P
Sbjct: 206 PVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVE--------CSQPE 257
Query: 254 TEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELI 313
+ F ++S RE K + L +I+G F+ WLPFFI I
Sbjct: 258 SSF-----------------------KMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCI 294
Query: 314 VGL------SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
+ + + S D W G+ NS +NP++Y +FN DF+ AF L+ C
Sbjct: 295 LPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIY-AFNADFRKAFSTLLGC 347
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 175 bits (444), Expect = 5e-44
Identities = 113/349 (32%), Positives = 166/349 (47%), Gaps = 50/349 (14%)
Query: 23 MLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIY 82
M I M+L+V+ + N+ VI AI ++L NY I SLA DL++ + V+P +
Sbjct: 36 MGIVMSLIVLAIVFG--NVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAH 93
Query: 83 IVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALM 142
I+M W G F CE W S+D+ C T SI LCVIA+DRY+AIT+ +Y T +A ++
Sbjct: 94 ILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVI 153
Query: 143 ILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQH------DHVIYTIYSTLGAFYIPLT 196
IL VW +S S P+ +R C + Y I S++ +FY+PL
Sbjct: 154 ILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLV 213
Query: 197 LILILYYRIYHAAKSLYQKRGSSR---HLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT 253
+++ +Y R++ AK QK S H+ N S Q
Sbjct: 214 IMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQ----------------------- 250
Query: 254 TEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELI 313
D H R +E KA + LG+I+G F L WLPFFI ++
Sbjct: 251 ---------------DGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIV 295
Query: 314 VGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
+ + EV L W+GYVNS NPL+Y + DF++AF++L+ R
Sbjct: 296 HVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQELLCLR 343
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 175 bits (444), Expect = 5e-44
Identities = 98/325 (30%), Positives = 171/325 (52%), Gaps = 20/325 (6%)
Query: 40 NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWL 99
NL VI+++ + L NY I +LAV DLL++ V+P S V+ W G C+VW
Sbjct: 114 NLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWA 173
Query: 100 SVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF 159
+VD+ CCT SIL LC I++DRY + ++++Y T ++AA ++ +W +++ +S+ PL
Sbjct: 174 AVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLL 233
Query: 160 -WRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGS 218
W+ PP + + Y ++S++ +FY+P+ +I+++Y R+Y A+S + +
Sbjct: 234 GWKEP---VPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEA 290
Query: 219 SRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGER 278
C+ T +D + + + F +S+ +
Sbjct: 291 GVKRERGKASEVVLRIHCRGAAT--GADGAHGMRSAKGHTFRSSLSV------------- 335
Query: 279 QQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSE-VADFLTWLGYVNS 337
+ + +RE+KAA+ L +++G F+L W PFF + L SE V + WLGY NS
Sbjct: 336 RLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNS 395
Query: 338 LINPLLYTSFNEDFKLAFKKLIRCR 362
+NPL+Y + +FK AF +L+RC+
Sbjct: 396 CVNPLIYPCSSREFKRAFLRLLRCQ 420
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 166 bits (421), Expect = 2e-41
Identities = 117/375 (31%), Positives = 185/375 (49%), Gaps = 74/375 (19%)
Query: 40 NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDR--WKLGYFLCEV 97
N V MA+ + L NYL+ SLAV DLLVA LVMP ++Y+ + W C+V
Sbjct: 47 NGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEVTGGVWNFSRICCDV 105
Query: 98 WLSVDMTCCTCSILHLCVIALDRYWAITNAIEYAR---KRTAKRAALMILTVWTISIFIS 154
++++D+ CT SIL+LC I++DRY A+ + Y + + +R ALMI VW ++ +S
Sbjct: 106 FVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS 165
Query: 155 MPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQ 214
P LF + + P+ C+I + + IYS++ +FY+P + +++Y RIY K +
Sbjct: 166 CPLLFGFN---TTGDPTVCSISNPD--FVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRR 220
Query: 215 KRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT-TEFEKFHASIRIPPFDNDLD 273
KR +R QNS C + + DP E +++++ + D L
Sbjct: 221 KRILTR---------QNS--QCNSVRPGFPQQTLSPDPAHLELKRYYSICQ----DTALG 265
Query: 274 HPG-------------ERQQISST---------------------------------RER 287
PG R +S T RE+
Sbjct: 266 GPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREK 325
Query: 288 KAARILGLILGAFILSWLPFFIKELI-VGLSIYTVSSEVADFLTWLGYVNSLINPLLYTS 346
KA +++ ++LGAFI+ WLPFF+ ++ VS E+ TWLGYVNS +NP++YT+
Sbjct: 326 KATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTT 385
Query: 347 FNEDFKLAFKKLIRC 361
FN +F+ AF K++ C
Sbjct: 386 FNIEFRKAFLKILSC 400
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 160 bits (406), Expect = 1e-39
Identities = 106/347 (30%), Positives = 175/347 (50%), Gaps = 18/347 (5%)
Query: 25 ICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIV 84
+ + +V+I T+ N VI+A+ KKL NY + SLAV DLLV + VMP++++ I+
Sbjct: 59 LLILMVIIPTIGG--NTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIM 116
Query: 85 MDR-WKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMI 143
+ W L LC WL +D+ T SI+HLC I++DRY AI I+ + + A + I
Sbjct: 117 FEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKI 176
Query: 144 LTVWTISIFISMP-PLFWRSHRRLSPPPSQCTIQHDHV-IYTIYSTLGAFYIPLTLILIL 201
VW ISI I++P P+ +P C + + + ++ +L AF+ PL ++++
Sbjct: 177 TVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVT 236
Query: 202 YYRIYHA--AKSLYQKRGSSRHLS--NRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFE 257
Y+ HA K+ K + L+ ST Q C + + D S D
Sbjct: 237 YFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNS 296
Query: 258 KFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGL- 316
+R G++ + + E++A+++LG++ F+L W PFFI + + L
Sbjct: 297 GDETLMR------RTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC 350
Query: 317 --SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
T + + W+GYV+S +NPL+YT FN+ F+ AF + I C
Sbjct: 351 DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 397
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 158 bits (400), Expect = 6e-39
Identities = 115/371 (30%), Positives = 171/371 (46%), Gaps = 78/371 (21%)
Query: 27 MTLVVITTLTTLLNLAVIMAIGTTKKLH-QPANYLICSLAVTDLLVAVLVMPLSIIYIVM 85
+TL++I TL L N+ V AI ++ L N I SLAV+DL VA+LVMP + V
Sbjct: 47 LTLLIIWTL--LGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVA 104
Query: 86 DRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILT 145
W G F C+VW++ D+ C T SIL+LCVI++DRYWAI+ Y RK T + A +M+
Sbjct: 105 GYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGL 163
Query: 146 VWTISIFISMPPLFWRSHRRLSPPPSQCTIQHD-------------------------HV 180
WT+SI IS P+ HR + + ++ +
Sbjct: 164 AWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNR 223
Query: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240
Y I S+L +FYIP+ ++++ Y RIY A+ ++ S + + ++S A
Sbjct: 224 TYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA------ 277
Query: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
C D S ASI+ +E K + L +I+G F
Sbjct: 278 --CAPDTS----------LRASIK--------------------KETKVLKTLSVIMGVF 305
Query: 301 ILSWLPFFIKELIVGL----------SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNED 350
+ WLPFFI +V VS D W G+ NS +NP++Y +FN D
Sbjct: 306 VCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIY-AFNAD 364
Query: 351 FKLAFKKLIRC 361
F+ F +L+ C
Sbjct: 365 FQKVFAQLLGC 375
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 157 bits (397), Expect = 1e-38
Identities = 100/343 (29%), Positives = 163/343 (47%), Gaps = 40/343 (11%)
Query: 25 ICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIV 84
+ L V+ LT N +I I T L +N+ + SL +DL+V ++VMP +++ +
Sbjct: 29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
Query: 85 MDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMIL 144
RW L LC +W + D+ CC+ SIL+LC+I+LDRY I + + Y + T RA ++L
Sbjct: 89 YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVL 148
Query: 145 TVWTISIFISMPPLF--WRSHRRLSPP-PSQCTIQHDHVIYTIYSTLGAFYIPLTLILIL 201
W+++ S PL W PP P QC + + S L F++P I
Sbjct: 149 GAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGL-TFFLPSGAICFT 207
Query: 202 YYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHA 261
Y RI AA+ Q V+ +T + E
Sbjct: 208 YCRILLAARK----------------------------QAVQVASLTTGMASQASE---- 235
Query: 262 SIRIPPFDNDLDHPGERQQISSTRERKAAR---ILGLILGAFILSWLPFFIKELIVGLSI 318
++++P + +++++ RKA + LG++LG F ++WLPFF+ ++ +
Sbjct: 236 TLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAV-C 294
Query: 319 YTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
+S + D LTWLGY NS +NP++Y F DFK A + + C
Sbjct: 295 DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 157 bits (396), Expect = 2e-38
Identities = 104/347 (29%), Positives = 164/347 (47%), Gaps = 64/347 (18%)
Query: 22 KMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSII 81
K+ I + L V+ +T N+ V +A+G ++L N I SLA+TDLL+ +LV+P S I
Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77
Query: 82 YIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAAL 141
Y + +W G C ++ S+D+ CT SIL+L +I+LDRY A+ + + Y T R A+
Sbjct: 78 YQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
Query: 142 MILTVWTISIFISMPP--LFWRSHRRLSP---PPSQCTIQHDHVIYTIYSTLGAFYIPLT 196
++ +W ISI +S L W S S S+C +Q + V Y + L FY+PL
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEV-YGLVDGLVTFYLPLL 196
Query: 197 LILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEF 256
++ I YYRI+ A R ++ +++ S+ + K T T
Sbjct: 197 IMCITYYRIFKVA------RDQAKRINHISSWKAATIREHKATVTL-------------- 236
Query: 257 EKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGL 316
A ++G AFI+ W P+F + GL
Sbjct: 237 ---------------------------------AAVMG----AFIICWFPYFTAFVYRGL 259
Query: 317 SIYTVSSEVAD-FLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
+EV + + WLGY NS +NP+LY + N DF+ +++L CR
Sbjct: 260 RGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCR 306
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 157 bits (396), Expect = 2e-38
Identities = 104/347 (29%), Positives = 164/347 (47%), Gaps = 64/347 (18%)
Query: 22 KMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSII 81
K+ I + L V+ +T N+ V +A+G ++L N I SLA+TDLL+ +LV+P S I
Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77
Query: 82 YIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAAL 141
Y + +W G C ++ S+D+ CT SIL+L +I+LDRY A+ + + Y T R A+
Sbjct: 78 YQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
Query: 142 MILTVWTISIFISMPP--LFWRSHRRLSP---PPSQCTIQHDHVIYTIYSTLGAFYIPLT 196
++ +W ISI +S L W S S S+C +Q + V Y + L FY+PL
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEV-YGLVDGLVTFYLPLL 196
Query: 197 LILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEF 256
++ I YYRI+ A R ++ +++ S+ + K T T
Sbjct: 197 IMCITYYRIFKVA------RDQAKRINHISSWKAATIREHKATVTL-------------- 236
Query: 257 EKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGL 316
A ++G AFI+ W P+F + GL
Sbjct: 237 ---------------------------------AAVMG----AFIICWFPYFTAFVYRGL 259
Query: 317 SIYTVSSEVAD-FLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
+EV + + WLGY NS +NP+LY + N DF+ +++L CR
Sbjct: 260 RGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCR 306
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 153 bits (387), Expect = 2e-37
Identities = 110/363 (30%), Positives = 161/363 (44%), Gaps = 73/363 (20%)
Query: 21 EKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQ-PANYLICSLAVTDLLVAVLVMPLS 79
EK+++ L + + L NL V++A+ ++L + NY I SLA DLLV+VLVMP
Sbjct: 18 EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFG 77
Query: 80 IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAI-TNAIEYARKRTAKR 138
I +V D W G C V S+D+ T SI HLC I+LDRY+AI + Y K T R
Sbjct: 78 AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLR 137
Query: 139 AALMILTVWTISIFISMPPLF--WRSHRRLSPPPSQCTIQHDHVIYTIY---------ST 187
ALM+ W I FIS P+ W + + + Q+ + Y ++ +
Sbjct: 138 IALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCS 197
Query: 188 LGAFYIPLTLILILYYRIYHAAK------SLYQKRGSSRHLSNRSTDSQNSF---ASCKL 238
+ AFYIP L+++ YYRIY AK + Q+ G+S +S D ++ K
Sbjct: 198 VVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKA 257
Query: 239 TQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILG 298
+T C+ I+G
Sbjct: 258 AKTLCI---------------------------------------------------IMG 266
Query: 299 AFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKL 358
F L W PFF+ ++ YTV +V WLGY+NS +NP LY N+ F+ AF +
Sbjct: 267 CFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLII 326
Query: 359 IRC 361
+ C
Sbjct: 327 LCC 329
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 153 bits (387), Expect = 2e-37
Identities = 110/363 (30%), Positives = 161/363 (44%), Gaps = 73/363 (20%)
Query: 21 EKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQ-PANYLICSLAVTDLLVAVLVMPLS 79
EK+++ L + + L NL V++A+ ++L + NY I SLA DLLV+VLVMP
Sbjct: 18 EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFG 77
Query: 80 IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAI-TNAIEYARKRTAKR 138
I +V D W G C V S+D+ T SI HLC I+LDRY+AI + Y K T R
Sbjct: 78 AIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLR 137
Query: 139 AALMILTVWTISIFISMPPLF--WRSHRRLSPPPSQCTIQHDHVIYTIY---------ST 187
ALM+ W I FIS P+ W + + + Q+ + Y ++ +
Sbjct: 138 IALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCS 197
Query: 188 LGAFYIPLTLILILYYRIYHAAK------SLYQKRGSSRHLSNRSTDSQNSF---ASCKL 238
+ AFYIP L+++ YYRIY AK + Q+ G+S +S D ++ K
Sbjct: 198 VVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKA 257
Query: 239 TQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILG 298
+T C+ I+G
Sbjct: 258 AKTLCI---------------------------------------------------IMG 266
Query: 299 AFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKL 358
F L W PFF+ ++ YTV +V WLGY+NS +NP LY N+ F+ AF +
Sbjct: 267 CFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLII 326
Query: 359 IRC 361
+ C
Sbjct: 327 LCC 329
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,049,583
Number of Sequences: 37866
Number of extensions: 512955
Number of successful extensions: 3233
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 500
Number of HSP's successfully gapped in prelim test: 168
Number of HSP's that attempted gapping in prelim test: 1743
Number of HSP's gapped (non-prelim): 1200
length of query: 365
length of database: 18,247,518
effective HSP length: 104
effective length of query: 261
effective length of database: 14,309,454
effective search space: 3734767494
effective search space used: 3734767494
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.