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Search of human proteins with 4504533
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
(390 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 783 0.0
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 472 e-133
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 337 1e-92
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 317 1e-86
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 297 1e-80
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 218 1e-56
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 218 1e-56
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 218 1e-56
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 218 1e-56
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 215 6e-56
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 215 6e-56
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 215 6e-56
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 214 1e-55
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 207 1e-53
gi|4503383 dopamine receptor D1 [Homo sapiens] 204 8e-53
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 203 2e-52
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 196 4e-50
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 194 1e-49
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 191 1e-48
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 186 4e-47
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 184 9e-47
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 182 3e-46
gi|4503391 dopamine receptor D5 [Homo sapiens] 179 4e-45
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 171 8e-43
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 169 3e-42
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 162 5e-40
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 160 1e-39
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 160 1e-39
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 160 2e-39
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 158 7e-39
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 783 bits (2022), Expect = 0.0
Identities = 390/390 (100%), Positives = 390/390 (100%)
Query: 1 MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT 60
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT
Sbjct: 1 MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT 60
Query: 61 LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV 120
LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV
Sbjct: 61 LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV 120
Query: 121 VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI 180
VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI
Sbjct: 121 VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI 180
Query: 181 SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL 240
SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL
Sbjct: 181 SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL 240
Query: 241 KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE 300
KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE
Sbjct: 241 KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE 300
Query: 301 KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL 360
KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL
Sbjct: 301 KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL 360
Query: 361 NSLINPIIYTMSNEDFKQAFHKLIRFKCTS 390
NSLINPIIYTMSNEDFKQAFHKLIRFKCTS
Sbjct: 361 NSLINPIIYTMSNEDFKQAFHKLIRFKCTS 390
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 472 bits (1215), Expect = e-133
Identities = 230/343 (67%), Positives = 280/343 (81%), Gaps = 4/343 (1%)
Query: 49 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 108
K+ L ++L++ITLAT LSNAFV+ T+ TRKLHTPANYLI SLA TDLLVSILVMPIS
Sbjct: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97
Query: 109 YTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAV 168
YT+T W GQ++CD WLSSDITCCTASILHLCVIALDRYWAITDA+EYS +RT AA
Sbjct: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT 157
Query: 169 MIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALY 228
MIA+VW SI IS+PP FWRQAKA+EE+S+C+VNT I YT+YST GAFY P++LLI LY
Sbjct: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
Query: 229 GRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSES-GSPVYV 287
GRIY AR+RIL P+ GKR T A LIT S G SS+ S+NS + + S S GSP++
Sbjct: 218 GRIYRAARNRIL-NPPSLYGKRFTTAHLITGSAG--SSLCSLNSSLHEGHSHSAGSPLFF 274
Query: 288 NQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFH 347
N VK++++D+ LE+K++ AARERKATK LGIILGAFI+CWLPFF++SLV+PIC+D+CW H
Sbjct: 275 NHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIH 334
Query: 348 LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS 390
A+FDFFTWLGYLNSLINPIIYT+ NE+F+QAF K++ F+ S
Sbjct: 335 PALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS 377
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 337 bits (864), Expect = 1e-92
Identities = 175/368 (47%), Positives = 240/368 (65%), Gaps = 12/368 (3%)
Query: 27 SAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANY 86
++ QN ++++ + + +P K+L+ + L+ + L TT N+ VIA + TRKLH PANY
Sbjct: 5 NSSDQNLTSEELLNR----MPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY 60
Query: 87 LIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALD 146
LI SLAVTD LV++LVMP S +Y V W +GQVVCD WLS DITCCT SILHL IALD
Sbjct: 61 LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 120
Query: 147 RYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHI 206
RY AITDAVEY+ KRTPK A +MI +VW+ S+ IS+PP FWR + EC++ DHI
Sbjct: 121 RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRD-DECIIKHDHI 179
Query: 207 LYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDS-PGSTS 265
+ T+YST GAFY P L++ LY +IY A++ K+ +R K Q++ +S ST
Sbjct: 180 VSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTK 239
Query: 266 SVTS--INSRVPDVPSESGSPVYVNQVKVRVS---DALLEKKKLMAARERKATKTLGIIL 320
SV++ + + PS ++ +R + ++K+ RERKA TLG+IL
Sbjct: 240 SVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLIL 299
Query: 321 GAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 380
GAF++CWLPFF+ LV+ +C D C + +F WLGYLNSLINP+IYT+ NEDFK+AF
Sbjct: 300 GAFVICWLPFFVKELVVNVC-DKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAF 358
Query: 381 HKLIRFKC 388
KL+R +C
Sbjct: 359 QKLVRCRC 366
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 317 bits (812), Expect = 1e-86
Identities = 174/362 (48%), Positives = 232/362 (64%), Gaps = 14/362 (3%)
Query: 32 NCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASL 91
NC+ + + ++ K+L+ M L +IT TTL N VI + T+KLH PANYLI SL
Sbjct: 5 NCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSL 64
Query: 92 AVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAI 151
AVTDLLV++LVMP+S +Y V RW LG +C+ WLS D+TCCT SILHLCVIALDRYWAI
Sbjct: 65 AVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAI 124
Query: 152 TDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWR-QAKAEEEVSECVVNTDHILYTV 210
T+A+EY+ KRT KRAA+MI VW SI IS+PP FWR + S+C + DH++YT+
Sbjct: 125 TNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTI 184
Query: 211 YSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNR-TGKRLTRAQ--LITDSPGSTSSV 267
YST+GAFY P L++ LY RIY A+S K+ +R R T +Q + T V
Sbjct: 185 YSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCV 244
Query: 268 TSINSRVPDVPSESGSPVYVNQVKVRVSDALL----EKKKLMAARERKATKTLGIILGAF 323
+ ++ P E + +++ D L E++++ + RERKA + LG+ILGAF
Sbjct: 245 SDFSTSDPTTEFEK----FHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
Query: 324 IVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL 383
I+ WLPFFI L++ + +A DF TWLGY+NSLINP++YT NEDFK AF KL
Sbjct: 301 ILSWLPFFIKELIVGLSIYTVSSEVA--DFLTWLGYVNSLINPLLYTSFNEDFKLAFKKL 358
Query: 384 IR 385
IR
Sbjct: 359 IR 360
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 297 bits (760), Expect = 1e-80
Identities = 160/393 (40%), Positives = 227/393 (57%), Gaps = 54/393 (13%)
Query: 44 ISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVM 103
+++ ++V+ +LL + L NA V+A + R L ANYLI SLAVTDL+VS+LV+
Sbjct: 31 VTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVL 90
Query: 104 PISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTP 163
P++ +Y V +WTLGQV CD +++ D+ CCT+SILHLC IALDRYWAITD ++Y KRTP
Sbjct: 91 PMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTP 150
Query: 164 KRAAVMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTL 222
+RAA +I+L W+ IS+PP WR + + C ++ DH YT+YST GAFY P L
Sbjct: 151 RRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH-GYTIYSTFGAFYIPLL 209
Query: 223 LLIALYGRIYVEARSRI------------------------LKQTPNRTGKRLTRAQLIT 258
L++ LYGRI+ AR RI K +G R R + +
Sbjct: 210 LMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVES 269
Query: 259 DSPGSTSS--------------------VTSINSRVPDVPSESG----SPVYVNQVKVRV 294
+ G+ + V + +P +PSE+G +P + R
Sbjct: 270 KAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLP-LPSEAGPTPCAPASFERKNERN 328
Query: 295 SDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFF 354
++A K+K+ ARERK KTLGII+G FI+CWLPFFI++LV+P C+ +C +
Sbjct: 329 AEA---KRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAII 385
Query: 355 TWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK 387
WLGY NSL+NP+IY N+DF+ AF K+I+ K
Sbjct: 386 NWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 218 bits (554), Expect = 1e-56
Identities = 131/366 (35%), Positives = 205/366 (56%), Gaps = 30/366 (8%)
Query: 26 SSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPAN 85
+++ S NC+ +++ +LL ++L + L L N VI +V R LH+ +
Sbjct: 7 NASDSSNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
Query: 86 YLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIAL 145
Y I +LAV DLL++ V+P S ++ V G W G+V C+ W + D+ CCTASI+ LC+I++
Sbjct: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 146 DRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTD 204
DRY ++ + Y T +R + + VW S+ IS+ P F WRQ E+E + C +N +
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDE-TICQIN-E 180
Query: 205 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGST 264
Y ++S +G+FY P +++ +Y R+YV A+ R ++ L TD S
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE----------SRGLKSGLKTDKSDSE 230
Query: 265 SSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 324
I+ + + P+ GS + + K S LL+ +RE+KA KTLGI++G F+
Sbjct: 231 QVTLRIHRK--NAPA-GGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFV 282
Query: 325 VCWLPFFIISLVMPICKDACWFHLA--IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 382
+CWLPFF LVMPI F + +F WLGYLNS INPIIY S+++FK+AF
Sbjct: 283 LCWLPFF---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN 339
Query: 383 LIRFKC 388
++R +C
Sbjct: 340 VLRIQC 345
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 218 bits (554), Expect = 1e-56
Identities = 131/366 (35%), Positives = 205/366 (56%), Gaps = 30/366 (8%)
Query: 26 SSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPAN 85
+++ S NC+ +++ +LL ++L + L L N VI +V R LH+ +
Sbjct: 7 NASDSSNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
Query: 86 YLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIAL 145
Y I +LAV DLL++ V+P S ++ V G W G+V C+ W + D+ CCTASI+ LC+I++
Sbjct: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 146 DRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTD 204
DRY ++ + Y T +R + + VW S+ IS+ P F WRQ E+E + C +N +
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDE-TICQIN-E 180
Query: 205 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGST 264
Y ++S +G+FY P +++ +Y R+YV A+ R ++ L TD S
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE----------SRGLKSGLKTDKSDSE 230
Query: 265 SSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 324
I+ + + P+ GS + + K S LL+ +RE+KA KTLGI++G F+
Sbjct: 231 QVTLRIHRK--NAPA-GGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFV 282
Query: 325 VCWLPFFIISLVMPICKDACWFHLA--IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 382
+CWLPFF LVMPI F + +F WLGYLNS INPIIY S+++FK+AF
Sbjct: 283 LCWLPFF---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN 339
Query: 383 LIRFKC 388
++R +C
Sbjct: 340 VLRIQC 345
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 218 bits (554), Expect = 1e-56
Identities = 131/366 (35%), Positives = 205/366 (56%), Gaps = 30/366 (8%)
Query: 26 SSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPAN 85
+++ S NC+ +++ +LL ++L + L L N VI +V R LH+ +
Sbjct: 7 NASDSSNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
Query: 86 YLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIAL 145
Y I +LAV DLL++ V+P S ++ V G W G+V C+ W + D+ CCTASI+ LC+I++
Sbjct: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 146 DRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTD 204
DRY ++ + Y T +R + + VW S+ IS+ P F WRQ E+E + C +N +
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDE-TICQIN-E 180
Query: 205 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGST 264
Y ++S +G+FY P +++ +Y R+YV A+ R ++ L TD S
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE----------SRGLKSGLKTDKSDSE 230
Query: 265 SSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 324
I+ + + P+ GS + + K S LL+ +RE+KA KTLGI++G F+
Sbjct: 231 QVTLRIHRK--NAPA-GGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFV 282
Query: 325 VCWLPFFIISLVMPICKDACWFHLA--IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 382
+CWLPFF LVMPI F + +F WLGYLNS INPIIY S+++FK+AF
Sbjct: 283 LCWLPFF---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN 339
Query: 383 LIRFKC 388
++R +C
Sbjct: 340 VLRIQC 345
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 218 bits (554), Expect = 1e-56
Identities = 131/366 (35%), Positives = 205/366 (56%), Gaps = 30/366 (8%)
Query: 26 SSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPAN 85
+++ S NC+ +++ +LL ++L + L L N VI +V R LH+ +
Sbjct: 7 NASDSSNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
Query: 86 YLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIAL 145
Y I +LAV DLL++ V+P S ++ V G W G+V C+ W + D+ CCTASI+ LC+I++
Sbjct: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 146 DRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTD 204
DRY ++ + Y T +R + + VW S+ IS+ P F WRQ E+E + C +N +
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDE-TICQIN-E 180
Query: 205 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGST 264
Y ++S +G+FY P +++ +Y R+YV A+ R ++ L TD S
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE----------SRGLKSGLKTDKSDSE 230
Query: 265 SSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 324
I+ + + P+ GS + + K S LL+ +RE+KA KTLGI++G F+
Sbjct: 231 QVTLRIHRK--NAPA-GGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFV 282
Query: 325 VCWLPFFIISLVMPICKDACWFHLA--IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 382
+CWLPFF LVMPI F + +F WLGYLNS INPIIY S+++FK+AF
Sbjct: 283 LCWLPFF---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN 339
Query: 383 LIRFKC 388
++R +C
Sbjct: 340 VLRIQC 345
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 215 bits (547), Expect = 6e-56
Identities = 141/387 (36%), Positives = 206/387 (53%), Gaps = 38/387 (9%)
Query: 12 PPAGSETWVP----QANLSSAPSQNC---SAKDYIYQDSISLPWKVLLVMLLALITLATT 64
P AGS W P + S AP+ + +A Q + KV++ +L LITL T
Sbjct: 39 PVAGS--WAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTI 96
Query: 65 LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMP-ISTMYTVTGRWTLGQVVCD 123
N V+ +V +KL P+NYLI SLA+ DL V++ VMP +S + G+W G C+
Sbjct: 97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCN 156
Query: 124 FWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLP 183
+++ D+ CCTASI+ LCVI++DRY IT + Y ++ K A MI VW+ S SI+LP
Sbjct: 157 VFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP 216
Query: 184 PFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQ 242
P F W Q +++V C+++ D YT+YST AFY P +++ +Y +IY AR K
Sbjct: 217 PLFGWAQNVNDDKV--CLISQD-FGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH 273
Query: 243 TPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKK 302
K ++ DS + + + + V + +S L ++
Sbjct: 274 ------KFPGFPRVEPDSVIALNGIVKLQKEVEEC--------------ANLSRLLKHER 313
Query: 303 KLMA--ARERKATKTLGIILGAFIVCWLPFFIISLVMP-ICKDAC-WFHLAIFDFFTWLG 358
K ++ RE+KA TLGII+GAF VCWLPFF++S P IC +C L + F WLG
Sbjct: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373
Query: 359 YLNSLINPIIYTMSNEDFKQAFHKLIR 385
Y NSLINP IY N D + + L++
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQ 400
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 215 bits (547), Expect = 6e-56
Identities = 141/387 (36%), Positives = 206/387 (53%), Gaps = 38/387 (9%)
Query: 12 PPAGSETWVP----QANLSSAPSQNC---SAKDYIYQDSISLPWKVLLVMLLALITLATT 64
P AGS W P + S AP+ + +A Q + KV++ +L LITL T
Sbjct: 39 PVAGS--WAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTI 96
Query: 65 LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMP-ISTMYTVTGRWTLGQVVCD 123
N V+ +V +KL P+NYLI SLA+ DL V++ VMP +S + G+W G C+
Sbjct: 97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCN 156
Query: 124 FWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLP 183
+++ D+ CCTASI+ LCVI++DRY IT + Y ++ K A MI VW+ S SI+LP
Sbjct: 157 VFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP 216
Query: 184 PFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQ 242
P F W Q +++V C+++ D YT+YST AFY P +++ +Y +IY AR K
Sbjct: 217 PLFGWAQNVNDDKV--CLISQD-FGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH 273
Query: 243 TPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKK 302
K ++ DS + + + + V + +S L ++
Sbjct: 274 ------KFPGFPRVEPDSVIALNGIVKLQKEVEEC--------------ANLSRLLKHER 313
Query: 303 KLMA--ARERKATKTLGIILGAFIVCWLPFFIISLVMP-ICKDAC-WFHLAIFDFFTWLG 358
K ++ RE+KA TLGII+GAF VCWLPFF++S P IC +C L + F WLG
Sbjct: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373
Query: 359 YLNSLINPIIYTMSNEDFKQAFHKLIR 385
Y NSLINP IY N D + + L++
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQ 400
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 215 bits (547), Expect = 6e-56
Identities = 141/387 (36%), Positives = 206/387 (53%), Gaps = 38/387 (9%)
Query: 12 PPAGSETWVP----QANLSSAPSQNC---SAKDYIYQDSISLPWKVLLVMLLALITLATT 64
P AGS W P + S AP+ + +A Q + KV++ +L LITL T
Sbjct: 39 PVAGS--WAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTI 96
Query: 65 LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMP-ISTMYTVTGRWTLGQVVCD 123
N V+ +V +KL P+NYLI SLA+ DL V++ VMP +S + G+W G C+
Sbjct: 97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCN 156
Query: 124 FWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLP 183
+++ D+ CCTASI+ LCVI++DRY IT + Y ++ K A MI VW+ S SI+LP
Sbjct: 157 VFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP 216
Query: 184 PFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQ 242
P F W Q +++V C+++ D YT+YST AFY P +++ +Y +IY AR K
Sbjct: 217 PLFGWAQNVNDDKV--CLISQD-FGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH 273
Query: 243 TPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKK 302
K ++ DS + + + + V + +S L ++
Sbjct: 274 ------KFPGFPRVEPDSVIALNGIVKLQKEVEEC--------------ANLSRLLKHER 313
Query: 303 KLMA--ARERKATKTLGIILGAFIVCWLPFFIISLVMP-ICKDAC-WFHLAIFDFFTWLG 358
K ++ RE+KA TLGII+GAF VCWLPFF++S P IC +C L + F WLG
Sbjct: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373
Query: 359 YLNSLINPIIYTMSNEDFKQAFHKLIR 385
Y NSLINP IY N D + + L++
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQ 400
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 214 bits (545), Expect = 1e-55
Identities = 125/334 (37%), Positives = 188/334 (56%), Gaps = 28/334 (8%)
Query: 50 VLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMY 109
VL++ LL + AT N V+AT+ R R H + L+AS+AV+D+LV+ LVMP+S ++
Sbjct: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
Query: 110 TVTGR-WTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAV 168
++GR W LG+ +C W++ D+ CCTASI ++ IALDRYW+IT +EY+ + + V
Sbjct: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV 160
Query: 169 MIALVWVFSISISLPP--FFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIA 226
MIAL W S ISL P F W + +E EC V+ + Y V+STVGAFY P +++
Sbjct: 161 MIALTWALSAVISLAPLLFGWGETYSEGS-EECQVSREP-SYAVFSTVGAFYLPLCVVLF 218
Query: 227 LYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVY 286
+Y +IY A+ R+ G R T+SV+ I+ V +V + P
Sbjct: 219 VYWKIYKAAKFRV--------GSR------------KTNSVSPISEAV-EVKDSAKQPQM 257
Query: 287 VNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWF 346
V V+ E +E++A +GI++G F++CW+PFF+ L+ P+C +C
Sbjct: 258 VFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLC--SCDI 315
Query: 347 HLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 380
F WLGY NS NP+IYT N+++ AF
Sbjct: 316 PAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 207 bits (527), Expect = 1e-53
Identities = 121/335 (36%), Positives = 185/335 (55%), Gaps = 17/335 (5%)
Query: 54 MLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTG 113
++L L + N VI +V R L TP NY I +LA+ DLL+S V+P S V G
Sbjct: 50 LVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG 109
Query: 114 RWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALV 173
W LG++ CD W + D+ CCTASIL LC I++DRY + +++Y T ++A + + V
Sbjct: 110 YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSV 169
Query: 174 WVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYV 233
WV S IS+ P + A + EC V T+ Y ++S++G+FY P +++ +Y R+Y+
Sbjct: 170 WVLSTVISIGPLLGWKEPAPNDDKECGV-TEEPFYALFSSLGSFYIPLAVILVMYCRVYI 228
Query: 234 EARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVR 293
A+ RT K L A ++ + S I+S+ + ++ S R
Sbjct: 229 VAK---------RTTKNL-EAGVMKEMSNSKELTLRIHSK--NFHEDTLSSTKAKGHNPR 276
Query: 294 VSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDF 353
S A+ K +RE+KA KTLGI++G FI+CWLPFF I+L + A+F
Sbjct: 277 SSIAV---KLFKFSREKKAAKTLGIVVGMFILCWLPFF-IALPLGSLFSTLKPPDAVFKV 332
Query: 354 FTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKC 388
WLGY NS +NPIIY S+++FK+AF +++ +C
Sbjct: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQC 367
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 204 bits (520), Expect = 8e-53
Identities = 127/353 (35%), Positives = 185/353 (52%), Gaps = 47/353 (13%)
Query: 49 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPA-NYLIASLAVTDLLVSILVMPIST 107
++L L+L+ L+T L N V A V R R L + N+ + SLAV+DLLV++LVMP
Sbjct: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
Query: 108 MYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAA 167
+ + G W G C+ W++ DI C TASIL+LCVI++DRYWAI+ Y K TPK A
Sbjct: 83 VAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAF 141
Query: 168 VMIALVWVFSISISLPP--FFWRQAKAEE-------EVSECVVNTDHIL---YTVYSTVG 215
++I++ W S+ IS P W +AK ++E + N D L Y + S+V
Sbjct: 142 ILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVI 201
Query: 216 AFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVP 275
+FY P ++I Y RIY A+ +I R L RA +++++
Sbjct: 202 SFYIPVAIMIVTYTRIYRIAQKQI------RRIAALERA--------------AVHAKNC 241
Query: 276 DVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISL 335
+ +G PV +Q + K+ RE K KTL +I+G F+ CWLPFFI++
Sbjct: 242 QTTTGNGKPVECSQPE--------SSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNC 293
Query: 336 VMPICKDACWFHLAI----FDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
++P C I FD F W G+ NS +NPIIY N DF++AF L+
Sbjct: 294 ILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLL 345
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 203 bits (516), Expect = 2e-52
Identities = 117/341 (34%), Positives = 180/341 (52%), Gaps = 26/341 (7%)
Query: 54 MLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTG 113
+ LA L N VI +V R L T NY I +LAV DLL+S V+P S V G
Sbjct: 101 VFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG 160
Query: 114 RWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALV 173
W G+ CD W + D+ CCTASIL LC I++DRY + +++Y A T ++AA ++AL+
Sbjct: 161 FWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALL 220
Query: 174 WVFSISISLPPFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIY 232
WV ++ +S+ P W++ +E C + T+ Y V+S+V +FY P +++ +Y R+Y
Sbjct: 221 WVVALVVSVGPLLGWKEPVPPDE-RFCGI-TEEAGYAVFSSVCSFYLPMAVIVVMYCRVY 278
Query: 233 VEARS--RILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQV 290
V ARS R L+ R + + L G+ + + +
Sbjct: 279 VVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHG--------------MRSA 324
Query: 291 KVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFII---SLVMPICKDACWFH 347
K + L + L +RE+KA KTL I++G F++CW PFF + + P K +
Sbjct: 325 KGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS---- 380
Query: 348 LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKC 388
+F WLGY NS +NP+IY S+ +FK+AF +L+R +C
Sbjct: 381 EGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQC 421
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 196 bits (497), Expect = 4e-50
Identities = 126/381 (33%), Positives = 189/381 (49%), Gaps = 59/381 (15%)
Query: 55 LLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR 114
LL L+ N V V R + L T NYLI SLAV DLLV+ LVMP V G
Sbjct: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
Query: 115 WTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPK-RAAVMIALV 173
W ++ CD +++ D+ CTASIL+LC I++DRY A+ + Y+ + + K R VMI++V
Sbjct: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
Query: 174 WVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYV 233
WV S +IS P F + +EC++ + VYS++ +FY P ++ + +Y +IY+
Sbjct: 160 WVLSFTISCPLLF---GLNNADQNECIIANP--AFVVYSSIVSFYVPFIVTLLVYIKIYI 214
Query: 234 EARSRILKQTPNRTGK------------------RLTRAQLITDSPGSTSSVTSI----- 270
R R + R+ + L L + SP + + I
Sbjct: 215 VLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHH 274
Query: 271 NSRVPDVPSESG-----------------------SPVYVNQV----KVRVSDALLEKKK 303
+PD PS G + ++ Q K R S + ++K
Sbjct: 275 QLTLPD-PSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRK 333
Query: 304 LMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSL 363
L +E+KAT+ L I+LG FI+CWLPFFI ++ C C ++ FTWLGY+NS
Sbjct: 334 LSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD--CNIPPVLYSAFTWLGYVNSA 391
Query: 364 INPIIYTMSNEDFKQAFHKLI 384
+NPIIYT N +F++AF K++
Sbjct: 392 VNPIIYTTFNIEFRKAFLKIL 412
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 194 bits (493), Expect = 1e-49
Identities = 131/390 (33%), Positives = 191/390 (48%), Gaps = 18/390 (4%)
Query: 3 EPG-AQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITL 61
EPG A P P G+ T + + ++P + + +S W + +L+ALI L
Sbjct: 12 EPGNLSSAAPLPDGAAT-AARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVL 70
Query: 62 ATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVV 121
N VI + +T +L T N I SLA DL++ +LV+P V GRW G
Sbjct: 71 LIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFF 130
Query: 122 CDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISIS 181
C+ W S D+ C TASI LCVIALDRY AIT Y + T RA ++ VW S +S
Sbjct: 131 CELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVS 190
Query: 182 LPPFF--WRQAKAEE-----EVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVE 234
P W +A+++E +C + Y + S+V +FY P ++ +Y R++ E
Sbjct: 191 FLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFRE 250
Query: 235 ARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRV 294
A+ ++ K + +R SP + S + P P + + R
Sbjct: 251 AQKQVKK--IDSCERRFLGGPARPPSP--SPSPVPAPAPPPGPPRPAAAAATAPLANGRA 306
Query: 295 SDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFF 354
+L+A RE+KA KTLGII+G F +CWLPFF+ ++V ++ L F FF
Sbjct: 307 GKR--RPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRL--FVFF 362
Query: 355 TWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
WLGY NS NPIIY S DF++AF L+
Sbjct: 363 NWLGYANSAFNPIIYCRS-PDFRKAFQGLL 391
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 191 bits (484), Expect = 1e-48
Identities = 125/343 (36%), Positives = 186/343 (54%), Gaps = 33/343 (9%)
Query: 59 ITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR-WTL 117
+ LA N V V + R L T NYL+ SLAV DLLV+ LVMP VTG W
Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
Query: 118 GQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEY---SAKRTPKRAAVMIALVW 174
++ CD +++ D+ CTASIL+LC I++DRY A+ V Y + + + +R A+MI VW
Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
Query: 175 VFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVE 234
V + ++S P F + V + N D + +YS+V +FY P + + +Y RIYV
Sbjct: 159 VLAFAVSCPLLFGFNTTGDPTVCS-ISNPD---FVIYSSVVSFYLPFGVTVLVYARIYV- 213
Query: 235 ARSRILKQTPNRTGKRLTR--AQLITDSPGSTSSVTSIN------SRVPDVPSES--GSP 284
+LKQ R + LTR +Q + PG S + R + ++ G P
Sbjct: 214 ----VLKQ--RRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
Query: 285 VYVNQVKVRVSDALLEKK---KLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICK 341
+ + R + E+K LM RE+KAT+ + I+LGAFIVCWLPFF+ ++ C+
Sbjct: 268 GF----QERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ 323
Query: 342 DACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
C ++ TWLGY+NS +NP+IYT N +F++AF K++
Sbjct: 324 -TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 186 bits (471), Expect = 4e-47
Identities = 118/350 (33%), Positives = 176/350 (50%), Gaps = 33/350 (9%)
Query: 46 LPWKVLLV-MLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMP 104
+PW+ L LLAL LAT N VI + T +L T N + SLA DL++ +LV+P
Sbjct: 33 VPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVP 92
Query: 105 ISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPK 164
+ +TG W LG C+ W S D+ C TASI LC +A+DRY A+T+ + Y A T +
Sbjct: 93 PAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKR 152
Query: 165 RAAVMIALVWVFSISISLPPFF--WRQAKAEEEVSECVVN------TDHILYTVYSTVGA 216
A + LVWV S ++S P W + A+ E C N ++ Y + S+ +
Sbjct: 153 CARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVS 212
Query: 217 FYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPD 276
FY P L+++ +Y R++V A ++ RL R +L P + P
Sbjct: 213 FYLPLLVMLFVYARVFVVATRQL----------RLLRGELGRFPPEES----------PP 252
Query: 277 VPSESGSPVYVNQVKVRVSDALLEKK--KLMAARERKATKTLGIILGAFIVCWLPFFIIS 334
PS S +P V ++ +L+ RE +A TLG+I+G F +CWLPFF+ +
Sbjct: 253 APSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLAN 312
Query: 335 LVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
++ + + A F WLGY NS NP+IY S DF+ AF +L+
Sbjct: 313 VLRALGGPSLVPGPA-FLALNWLGYANSAFNPLIYCRS-PDFRSAFRRLL 360
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 184 bits (468), Expect = 9e-47
Identities = 117/386 (30%), Positives = 189/386 (48%), Gaps = 51/386 (13%)
Query: 13 PAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIA 72
P ++ N S AP + + + +D + W V + ++++LI LA N VI
Sbjct: 4 PGNGSAFLLAPNRSHAPDHDVTQQ----RDEV---WVVGMGIVMSLIVLAIVFGNVLVIT 56
Query: 73 TVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITC 132
+ + +L T NY I SLA DL++ + V+P + + WT G C+FW S D+ C
Sbjct: 57 AIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLC 116
Query: 133 CTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPP--FFWRQA 190
TASI LCVIA+DRY+AIT +Y + T +A V+I +VW+ S S P W +A
Sbjct: 117 VTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA 176
Query: 191 KAEEEVSECVVNT------DHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTP 244
+E ++ C N + Y + S++ +FY P ++++ +Y R++ EA+ ++ K
Sbjct: 177 THQEAIN-CYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQK--- 232
Query: 245 NRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKL 304
D V +++ D + G L +
Sbjct: 233 -------------IDKSEGRFHVQNLSQVEQDGRTGHG----------------LRRSSK 263
Query: 305 MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLI 364
+E KA KTLGII+G F +CWLPFFI+++V I + ++ W+GY+NS
Sbjct: 264 FCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL--IRKEVYILLNWIGYVNSGF 321
Query: 365 NPIIYTMSNEDFKQAFHKLIRFKCTS 390
NP+IY S DF+ AF +L+ + +S
Sbjct: 322 NPLIYCRS-PDFRIAFQELLCLRRSS 346
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 182 bits (463), Expect = 3e-46
Identities = 120/367 (32%), Positives = 182/367 (49%), Gaps = 48/367 (13%)
Query: 59 ITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR-WTL 117
+ LA N V V + R L T NYL+ SLAV DLLV+ LVMP VTG W
Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
Query: 118 GQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEY---SAKRTPKRAAVMIALVW 174
++ CD +++ D+ CTASIL+LC I++DRY A+ V Y + + + +R A+MI VW
Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
Query: 175 VFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVE 234
V + ++S P F + V + N D + +YS+V +FY P + + +Y RIYV
Sbjct: 159 VLAFAVSCPLLFGFNTTGDPTVCS-ISNPD---FVIYSSVVSFYLPFGVTVLVYARIYVV 214
Query: 235 ARSRILKQTPNRTGKRLTRA------QLITDSPG--------STSSVTSINSRVPDVPSE 280
+ R K+ R + Q ++ P S T++ P
Sbjct: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGG--PGFQER 272
Query: 281 SGSPVYVNQVKVRVSDAL-----LEKKKL------------------MAARERKATKTLG 317
G + + +S + LE +KL + RE+KAT+ +
Sbjct: 273 GGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVA 332
Query: 318 IILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFK 377
I+LGAFIVCWLPFF+ ++ C+ C ++ TWLGY+NS +NP+IYT N +F+
Sbjct: 333 IVLGAFIVCWLPFFLTHVLNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFR 391
Query: 378 QAFHKLI 384
+AF K++
Sbjct: 392 KAFLKIL 398
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 179 bits (454), Expect = 4e-45
Identities = 122/374 (32%), Positives = 173/374 (46%), Gaps = 74/374 (19%)
Query: 47 PWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTP-ANYLIASLAVTDLLVSILVMPI 105
P +V+ LL L+ + T L N V A + R+R L N I SLAV+DL V++LVMP
Sbjct: 38 PSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPW 97
Query: 106 STMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKR 165
+ V G W G CD W++ DI C TASIL+LCVI++DRYWAI+ Y K T +
Sbjct: 98 KAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRM 156
Query: 166 AAVMIALVWVFSISISLPP--FFWRQAKA------------------EEEVSECVVNTDH 205
A VM+ L W SI IS P W + +A EE+ E VN ++
Sbjct: 157 ALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAEN 216
Query: 206 I------LYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITD 259
Y + S++ +FY P ++I Y RIY R+ + Q+
Sbjct: 217 CDSSLNRTYAISSSLISFYIPVAIMIVTYTRIY-----------------RIAQVQI--- 256
Query: 260 SPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGII 319
++S+ S S +R S +E K KTL +I
Sbjct: 257 -----RRISSLERAAEHAQSCRSSAACAPDTSLRAS----------IKKETKVLKTLSVI 301
Query: 320 LGAFIVCWLPFFIISLVMPICKD---------ACWFHLAIFDFFTWLGYLNSLINPIIYT 370
+G F+ CWLPFFI++ ++P C C FD F W G+ NS +NP+IY
Sbjct: 302 MGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPC-VSETTFDVFVWFGWANSSLNPVIYA 360
Query: 371 MSNEDFKQAFHKLI 384
N DF++ F +L+
Sbjct: 361 F-NADFQKVFAQLL 373
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 171 bits (434), Expect = 8e-43
Identities = 111/344 (32%), Positives = 185/344 (53%), Gaps = 29/344 (8%)
Query: 48 WKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIST 107
W LL ++ ++T+A N VI V +KL NY + SLA+ D+L+ LVMP+S
Sbjct: 76 WSALLTAVVIILTIA---GNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSM 132
Query: 108 MYTVTG-RWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRA 166
+ + G RW L +C W+ D+ TASI+HLC I+LDRY AI + + +S + +A
Sbjct: 133 LTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKA 192
Query: 167 AVMIALVWVFSISISLP-PFFWRQ--AKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLL 223
+ I VW S+ IS+P P F Q +K +E S C++ D+ + + + +F+ P +
Sbjct: 193 FLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGS-CLLADDN--FVLIGSFVSFFIPLTI 249
Query: 224 LIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGS 283
++ Y ++ +S + K+ TRA+L + S SS++S + E GS
Sbjct: 250 MVITY---FLTIKS-LQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGS 305
Query: 284 PVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDA 343
Y + + + E+KA K LGI+ F+V W PFFI +++ ICK++
Sbjct: 306 --YTGR-----------RTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKES 352
Query: 344 CWFHL--AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIR 385
C + A+ + F W+GYL+S +NP++YT+ N+ ++ AF + I+
Sbjct: 353 CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQ 396
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 169 bits (429), Expect = 3e-42
Identities = 106/347 (30%), Positives = 177/347 (51%), Gaps = 26/347 (7%)
Query: 48 WKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIST 107
W L ++++ ++T+ N VI V +KLH NY + SLA+ D+LV +LVMP+S
Sbjct: 55 WPALSIVIIIIMTIG---GNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSL 111
Query: 108 MYTVTGR-WTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRA 166
+ + W L + +C W+S D+ TASI+HLC I+LDRY AI + +E+S + +A
Sbjct: 112 LAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKA 171
Query: 167 AVMIALVWVFSISISLP-PFFWRQAKAEEEV----SECVVNTDHILYTVYSTVGAFYFPT 221
+ IA+VW SI +S+P P + EE+V + CV+N + + + + AF+ P
Sbjct: 172 IMKIAIVWAISIGVSVPIPVI--GLRDEEKVFVNNTTCVLNDPN--FVLIGSFVAFFIPL 227
Query: 222 LLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSES 281
+++ Y R + L T + PG + R S
Sbjct: 228 TIMVITYCLTIYVLRRQALMLLHGHT----------EEPPGLSLDFLKCCKRNTAEEENS 277
Query: 282 GSPVYVNQVKVRVSDALLEKKKLMAA-RERKATKTLGIILGAFIVCWLPFFIISLVMPIC 340
+P + R + + A ERKA+K LGI+ F++ W PFFI +++ +C
Sbjct: 278 ANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLC 337
Query: 341 KDACWFHL--AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIR 385
+ +C L + + F W+GY+ S INP++YT+ N+ +++AF +R
Sbjct: 338 EKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLR 384
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 162 bits (410), Expect = 5e-40
Identities = 93/242 (38%), Positives = 132/242 (54%), Gaps = 17/242 (7%)
Query: 12 PPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVI 71
P AG+ +W N + AP A Y Q +++L V L L+ L T N VI
Sbjct: 21 PDAGNASW----NGTEAPGGGARATPYSLQVTLTL------VCLAGLLMLLTVFGNVLVI 70
Query: 72 ATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDIT 131
V+ +R L P N + SLA D+LV+ LV+P S V G W G+ C+ +L+ D+
Sbjct: 71 IAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Query: 132 CCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAK 191
CT+SI+HLC I+LDRYW+IT A+EY+ KRTP+R +I VWV S IS PP + K
Sbjct: 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKK 190
Query: 192 A-----EEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNR 246
+ C +N D Y + S +G+F+ P L++I +Y RIY A+ R + P+R
Sbjct: 191 GGGGGPQPAEPRCEIN-DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRR-TRVPPSR 248
Query: 247 TG 248
G
Sbjct: 249 RG 250
Score = 77.8 bits (190), Expect = 2e-14
Identities = 35/92 (38%), Positives = 53/92 (57%), Gaps = 3/92 (3%)
Query: 293 RVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFD 352
RV A + + RE++ T L +++G F+VCW PFF + + C +F
Sbjct: 368 RVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFK 424
Query: 353 FFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
FF W GY NS +NP+IYT+ N DF++AF K++
Sbjct: 425 FFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 160 bits (406), Expect = 1e-39
Identities = 100/341 (29%), Positives = 158/341 (46%), Gaps = 62/341 (18%)
Query: 49 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 108
K+ + ++LA++ L T N V V R+L N I SLA+TDLL+ +LV+P S +
Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77
Query: 109 YTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAV 168
Y ++ +W+ G+V C+ + S D+ CTASIL+L +I+LDRY A+ D + Y TP R A+
Sbjct: 78 YQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
Query: 169 MIALVWVFSISISLPPFF--WRQ----AKAEEEVSECVVNTDHILYTVYSTVGAFYFPTL 222
+ L+WV SI++S W +K S+C V + + Y + + FY P L
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEV-YGLVDGLVTFYLPLL 196
Query: 223 LLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESG 282
++ Y RI+ AR + +
Sbjct: 197 IMCITYYRIFKVARDQAKR----------------------------------------- 215
Query: 283 SPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKD 342
+N + + + E K AT TL ++GAFI+CW P+F + + D
Sbjct: 216 ----INHISSWKAATIREHK---------ATVTLAAVMGAFIICWFPYFTAFVYRGLRGD 262
Query: 343 ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL 383
+ + WLGY NS +NPI+Y N DF+ + +L
Sbjct: 263 DA-INEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQL 302
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 160 bits (406), Expect = 1e-39
Identities = 100/341 (29%), Positives = 158/341 (46%), Gaps = 62/341 (18%)
Query: 49 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 108
K+ + ++LA++ L T N V V R+L N I SLA+TDLL+ +LV+P S +
Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77
Query: 109 YTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAV 168
Y ++ +W+ G+V C+ + S D+ CTASIL+L +I+LDRY A+ D + Y TP R A+
Sbjct: 78 YQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
Query: 169 MIALVWVFSISISLPPFF--WRQ----AKAEEEVSECVVNTDHILYTVYSTVGAFYFPTL 222
+ L+WV SI++S W +K S+C V + + Y + + FY P L
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEV-YGLVDGLVTFYLPLL 196
Query: 223 LLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESG 282
++ Y RI+ AR + +
Sbjct: 197 IMCITYYRIFKVARDQAKR----------------------------------------- 215
Query: 283 SPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKD 342
+N + + + E K AT TL ++GAFI+CW P+F + + D
Sbjct: 216 ----INHISSWKAATIREHK---------ATVTLAAVMGAFIICWFPYFTAFVYRGLRGD 262
Query: 343 ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL 383
+ + WLGY NS +NPI+Y N DF+ + +L
Sbjct: 263 DA-INEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQL 302
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 160 bits (405), Expect = 2e-39
Identities = 105/362 (29%), Positives = 187/362 (51%), Gaps = 23/362 (6%)
Query: 36 KDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTD 95
K + + L W LL++++ + T+ N VI V +KL NY + SLAV D
Sbjct: 44 KQIVEEQGNKLHWAALLILMVIIPTIG---GNTLVILAVSLEKKLQYATNYFLMSLAVAD 100
Query: 96 LLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDA 154
LLV + VMPI+ + + W L V+C WL D+ TASI+HLC I++DRY AI
Sbjct: 101 LLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKP 160
Query: 155 VEYSAKRTPKRAAVMIALVWVFSISISLP-PFFWRQAKAEEEVS-ECVVNTDHI-LYTVY 211
++ + + A + I +VW+ SI I++P P + + + CV+ + + ++
Sbjct: 161 IQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLF 220
Query: 212 STVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLIT-----DSPGSTSS 266
++ AF+ P ++I Y + + A + N+ +RLT + T ++P S+
Sbjct: 221 GSLAAFFTPLAIMIVTY-FLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPE 279
Query: 267 VTSI--NSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 324
++ SR SG ++ +R + + +K + E++A+K LGI+ F+
Sbjct: 280 KVAMLDGSRKDKALPNSG-----DETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFL 334
Query: 325 VCWLPFFIISLVMPICKDAC--WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 382
+ W PFFI ++ + +C D+C + + F W+GY++S +NP++YT+ N+ F+ AF +
Sbjct: 335 LMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGR 393
Query: 383 LI 384
I
Sbjct: 394 YI 395
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 158 bits (400), Expect = 7e-39
Identities = 101/335 (30%), Positives = 158/335 (47%), Gaps = 38/335 (11%)
Query: 56 LALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRW 115
L ++ T +N+ +IA + L +N+ + SL +DL+V ++VMP + + + GRW
Sbjct: 33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRW 92
Query: 116 TLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWV 175
L + +C W + D+ CC+ASIL+LC+I+LDRY I + Y + TP RA ++ W
Sbjct: 93 VLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWS 152
Query: 176 FSISISLPPFF--WRQ-AKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIY 232
+ S P W + A V + + + ++ F+ P+ + Y RI
Sbjct: 153 LAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRIL 212
Query: 233 VEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKV 292
+ AR K+ + +T S +S T R P ES
Sbjct: 213 LAAR------------KQAVQVASLTTGMASQASETLQVPRTPRPGVESA---------- 250
Query: 293 RVSDALLEKKKLMAARERKATK---TLGIILGAFIVCWLPFFIISLVMPICKDACWFHLA 349
+ ++L RKA K TLGI+LG F V WLPFF+ ++V +C
Sbjct: 251 -------DSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCD---CISPG 300
Query: 350 IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
+FD TWLGY NS +NPIIY + DFK+A + +
Sbjct: 301 LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFL 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.135 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,313,863
Number of Sequences: 37866
Number of extensions: 584536
Number of successful extensions: 4702
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 559
Number of HSP's successfully gapped in prelim test: 148
Number of HSP's that attempted gapping in prelim test: 2979
Number of HSP's gapped (non-prelim): 1344
length of query: 390
length of database: 18,247,518
effective HSP length: 104
effective length of query: 286
effective length of database: 14,309,454
effective search space: 4092503844
effective search space used: 4092503844
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.