Search of human proteins with 4504063

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504063 golgin 97 [Homo sapiens]
         (767 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504063 golgin 97 [Homo sapiens]                                  1453   0.0  
gi|21735548 centrosomal protein 2 [Homo sapiens]                      127   5e-29
gi|118498368 kinectin 1 isoform c [Homo sapiens]                      124   3e-28
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   123   6e-28
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]   122   1e-27
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    121   2e-27
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   121   2e-27
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   121   2e-27
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   121   2e-27
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   121   2e-27
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            119   8e-27
gi|38044112 restin isoform b [Homo sapiens]                           119   1e-26
gi|4506751 restin isoform a [Homo sapiens]                            119   1e-26
gi|118498362 kinectin 1 isoform b [Homo sapiens]                      117   3e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   117   3e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   117   3e-26
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   117   3e-26
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   117   4e-26
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   117   4e-26
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        117   4e-26
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                 117   4e-26
gi|118498356 kinectin 1 isoform a [Homo sapiens]                      117   5e-26
gi|33620775 kinectin 1 isoform a [Homo sapiens]                       117   5e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   116   7e-26
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   115   1e-25
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          115   2e-25
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          115   2e-25
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]          115   2e-25
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                  114   3e-25
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               114   3e-25

>gi|4504063 golgin 97 [Homo sapiens]
          Length = 767

 Score = 1453 bits (3762), Expect = 0.0
 Identities = 767/767 (100%), Positives = 767/767 (100%)

Query: 1   MFAKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQL 60
           MFAKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQL
Sbjct: 1   MFAKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQL 60

Query: 61  LRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKM 120
           LRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKM
Sbjct: 61  LRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKM 120

Query: 121 AEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQE 180
           AEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQE
Sbjct: 121 AEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQE 180

Query: 181 LSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTL 240
           LSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTL
Sbjct: 181 LSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTL 240

Query: 241 EEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKV 300
           EEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKV
Sbjct: 241 EEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKV 300

Query: 301 ASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELE 360
           ASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELE
Sbjct: 301 ASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELE 360

Query: 361 QTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIV 420
           QTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIV
Sbjct: 361 QTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIV 420

Query: 421 ALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSV 480
           ALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSV
Sbjct: 421 ALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSV 480

Query: 481 AMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALL 540
           AMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALL
Sbjct: 481 AMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALL 540

Query: 541 QIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQL 600
           QIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQL
Sbjct: 541 QIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQL 600

Query: 601 PTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPD 660
           PTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPD
Sbjct: 601 PTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPD 660

Query: 661 NELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAV 720
           NELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAV
Sbjct: 661 NELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAV 720

Query: 721 SVLLNFSQEEENMLKETLEYKMSWFGSKPAPKGSIRPSISNPRIPWS 767
           SVLLNFSQEEENMLKETLEYKMSWFGSKPAPKGSIRPSISNPRIPWS
Sbjct: 721 SVLLNFSQEEENMLKETLEYKMSWFGSKPAPKGSIRPSISNPRIPWS 767


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  127 bits (318), Expect = 5e-29
 Identities = 164/676 (24%), Positives = 306/676 (45%), Gaps = 84/676 (12%)

Query: 43   DDFASDGSSSREDLSSQLLRRNE---QIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQ 99
            D +  +G + R+ L      R+    Q   L+  +   +++   LQK +E+L   LE  +
Sbjct: 424  DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483

Query: 100  DSSMR------KFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQL 153
              + R      + Q Q ++ Q  + +  E L LA+ R+ +   E +  LE +++   ++L
Sbjct: 484  QEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAV-RERERLQEMLMGLEAKQSESLSEL 542

Query: 154  QEMKNQSMNLFQRRDEMDELEG-FQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRT 212
              ++           E   LEG   +QE +++   L + E+S+ ++         E++  
Sbjct: 543  ITLREAL--------ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADL 594

Query: 213  QEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALE----QKEQEL 268
            +   +  + ++  L+     L +    LEE+   V +    AE    AL+    + E+  
Sbjct: 595  RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR 654

Query: 269  QALIQQ---LSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKT 325
            +AL ++   L   LQK      E +  +  +QE+   ++K+L ++     H QE    + 
Sbjct: 655  EALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES----RHQQEAATTQ- 709

Query: 326  LAEQNLEDTRQQLLAARSSQAKAI-----NTLETRVRELEQTLQASEEQLQQSKGIVAAQ 380
            L + + E  RQ+ + AR+ Q K         LE R++ +E+  Q   EQLQ   G+ +A+
Sbjct: 710  LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ---GLSSAK 766

Query: 381  ETQIQELAAANQESSHVQQQALALEQQFLERTQA---LEAQIVALERTRAADQTTAEQ-- 435
            E     L  A Q++S ++     LE Q    TQA   ++ ++  L+     +++ AEQ  
Sbjct: 767  ELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER 826

Query: 436  --GMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEW-SQREIVSVAMAQALEEVRKQ 492
                RQL Q   A +E +   E+    H+ E+ +L+E+W  +R      +A+ALE + ++
Sbjct: 827  DAAARQLAQ---AEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883

Query: 493  REEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELE-- 550
            + E + +          KEQ   E   +  Q+E+E  Q E    SAL Q+ QL+ E E  
Sbjct: 884  KMELEMRL---------KEQQ-TEMEAIQAQREEERTQAE----SALCQM-QLETEKERV 928

Query: 551  -ALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNE-SHVTSRAMQDPVFQLPTAGRTPN 608
              L TL   +  +    + L RLR  ++ + L   E + +    +Q+   +L  A R   
Sbjct: 929  SLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988

Query: 609  GEVGAM---------DLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLE-LRKT-----LQK 653
             ++ A+         D   LQK+ +DL+ QL+ ++ + + ++Q + E LR+T     +QK
Sbjct: 989  DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQK 1048

Query: 654  ELKIRPDNELFEVREK 669
            EL+    +    + EK
Sbjct: 1049 ELEREKASLTLSLMEK 1064



 Score =  126 bits (317), Expect = 7e-29
 Identities = 168/737 (22%), Positives = 327/737 (44%), Gaps = 80/737 (10%)

Query: 67   IRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLAL 126
            +++ E +L+   EQ+R L+K +E     LE HQ   + K  +  E+ +     + + L  
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLE-HQLLELEKKDQMIESQRGQVQDLKKQLVT 1554

Query: 127  --ALARKDQEWSEKMD-----------QLEKEKNILTAQLQEMKNQSMNLFQRRDEMDEL 173
               LA + +E   KM+           Q E ++  LT    +++ +S  L  +  ++ +L
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614

Query: 174  EGFQQ---QELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKL 230
            E       +EL +    +  + E + +++++ E  T++L R  +ELM    +  +  Q L
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM----LQKERIQVL 1670

Query: 231  EELQ-RHYSTLEEQRDHVIASKTGAESKITALEQKEQELQ------ALIQQLSIDLQKVT 283
            E+ + R    LEE  + +  S      ++T   Q  QE        +  Q+ S++  K+ 
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730

Query: 284  AETQEKE-----DVITHLQEKVASLEKRLEQNLSGEEH--------VQELLKEKTLAEQN 330
               +EKE     + I  LQE    L+ +LEQ L G           + +  +E  + +Q 
Sbjct: 1731 LRDKEKEVECQQEHIHELQE----LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ 1786

Query: 331  LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAA 390
            L++ R+Q      S    ++  +  + + +Q L+A +++ QQ++G    QE +++E A A
Sbjct: 1787 LQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG----QEERVKEKADA 1842

Query: 391  NQ---ESSHVQQQALALE-QQFLERTQALEAQI-VALERTRAADQTTAEQGMRQLEQENA 445
             Q   E +H+  +    E Q   E+ + LE ++ V   R +A ++   +      EQE A
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKA 1902

Query: 446  ALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTA 505
             L   + +     Q H+ E + L++ W Q + V     Q LE +R + +  + Q     A
Sbjct: 1903 LL-ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961

Query: 506  IIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALR--TLKAEEAAVV 563
              +  ++ L +    L  KEQ +L+      S       LQA L+A +  + + EEA  +
Sbjct: 1962 RAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021

Query: 564  AE---QEDLLRLRGPLQ--AEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQ 618
             E   Q+  LR +  +Q   +AL+  +  +  +  ++ + +   A R     +       
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG 2081

Query: 619  LQKEKQD---LEQQLLEKNKTIKQMQQRMLELRKTLQK-ELKIRPDNELFEVREKPGPEM 674
             ++E+++   L Q + E   T+ Q +Q +LELR+T Q+  L+  P +      E+   ++
Sbjct: 2082 QEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL 2141

Query: 675  ANMAPSVTNNTD-------LTDAREINF-EYLKHVVLKFMSCRESEAFHLIKAVSVLLNF 726
             ++ P +    +        T+AREI + E  + + L     + S +   ++ V++ L  
Sbjct: 2142 DSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVS--SLQEVAMFLQA 2199

Query: 727  S----QEEENMLKETLE 739
            S      E+  L++ LE
Sbjct: 2200 SVLERDSEQQRLQDELE 2216



 Score =  113 bits (283), Expect = 6e-25
 Identities = 152/646 (23%), Positives = 271/646 (41%), Gaps = 69/646 (10%)

Query: 50   SSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQ 109
            SS   DL S       ++++ +  +    EQ+  LQ+ KE L   LE+ +D  +   +E+
Sbjct: 1608 SSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLER-RDQELMLQKER 1666

Query: 110  NETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
             +  +  R +  + L   L +      E+  +L  ++ ++  + +E K  S       + 
Sbjct: 1667 IQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH 1726

Query: 170  MDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQK 229
            M  +   +++E+   +  + + +E   ++EQ+L+   R++  T   L    Q    L Q+
Sbjct: 1727 MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ 1786

Query: 230  LEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEK 289
            L+E  R    L+EQ     + ++  +    AL Q++QEL+AL QQ     Q      +EK
Sbjct: 1787 LQEA-REQGELKEQ-----SLQSQLDEAQRALAQRDQELEAL-QQEQQQAQGQEERVKEK 1839

Query: 290  EDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAE----QNLEDTRQQLLAARSSQ 345
             D +    E+     K     L   +     L+E+   E    Q LE+    L A    Q
Sbjct: 1840 ADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQ 1899

Query: 346  AKAINTLETRVRELEQTLQASEEQLQ----QSKGIVAAQETQIQELAAANQESSHVQQQA 401
             KA+  L+ +  E  Q  +     LQ    Q++ ++  ++ +++ L A +Q S H ++ A
Sbjct: 1900 EKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAA 1959

Query: 402  LAL------------------EQQFLERTQ---ALEAQIVALERTRAADQTTAEQGMRQL 440
             A                   EQ  LE+ +   +LEA    L+ +  A Q  + Q    L
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019

Query: 441  EQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQR--EEFQQ 498
              +   +++    Y+  +Q  Q  L +  EE   ++       Q LE+   QR  E   Q
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQ----EREQLLEKSLAQRVQENMIQ 2075

Query: 499  QAANLTAIIDEKE-----QNLREKTEVLLQKEQEILQL----ERGHNSALLQIHQLQAEL 549
            +  NL    +E+E     Q++RE    L QKEQEIL+L    +R +  AL   H+     
Sbjct: 2076 EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME 2135

Query: 550  EALRTLKAEEAAVVAEQEDLLRLRGPL-QAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            E    L + E  +   Q +L RL+  L Q EA  +          QD    L     +  
Sbjct: 2136 EQSLKLDSLEPRL---QRELERLQAALRQTEAREIE----WREKAQDLALSLAQTKAS-- 2186

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKE 654
                   ++ LQ+    L+  +LE++   +++Q  +   R+ L+KE
Sbjct: 2187 -------VSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225



 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 150/665 (22%), Positives = 293/665 (44%), Gaps = 90/665 (13%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETF 113
            EDL SQL+ +++  R +E  + +   + +   +I+++LE        S M K Q      
Sbjct: 1013 EDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072

Query: 114  QANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQL----QEMKNQSMN-LFQRRD 168
            +A+  +  E   L+  R+D      M + + E+  L+AQ+    QE+K +  + L Q   
Sbjct: 1073 EADSIRQQE---LSALRQD------MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123

Query: 169  EMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQ 228
             ++ELE     E  +++  L  +E    +++  L +     + +Q E + + Q   + +Q
Sbjct: 1124 LLEELEASHITE-QQLRASLWAQEAKAAQLQLRLRS-----TESQLEALAAEQQPGNQAQ 1177

Query: 229  KLEELQRHYSTLEEQRDHVIASKT----GAES--KITALEQKEQELQALIQQ------LS 276
               +L   YS L++    V  S+     G +S   +  LE  +   ++L ++      LS
Sbjct: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237

Query: 277  ID--------LQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAE 328
             +        L +   +TQ+  DV   L+++V  LE+RL    +          EK+   
Sbjct: 1238 AEAVASALHKLHQDLWKTQQTRDV---LRDQVQKLEERLTDTEA----------EKSQVH 1284

Query: 329  QNLEDTRQQLLAARSSQAK---AINTLETRVRELEQT-------LQASEEQLQQSKG--- 375
              L+D ++QL   +  ++K     N+LE+ + EL +T       L+ +E Q  +++G   
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344

Query: 376  -IVAAQE---TQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQT 431
             + AA+E    Q++ L AA  E+      A  LE+       AL+ +   +E  R   Q 
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404

Query: 432  TAEQGMRQLE-----QENAALKEC----RNEYERSLQNHQFELKKLKE-EWSQREIVSVA 481
              EQG  ++      QEN AL       R E   +L+    EL+K +E + +  E++S+ 
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464

Query: 482  MAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQ 541
            + +  +EV  Q+E+  Q+     ++++     ++E+ + L  + ++I +LE+   +    
Sbjct: 1465 LKKRNQEVDLQQEQI-QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNV 1523

Query: 542  IHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLP 601
            +     ELE    +   +   V   +DL +    L+  AL + E+H      Q  + +L 
Sbjct: 1524 LEHQLLELEKKDQMIESQRGQV---QDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580

Query: 602  TAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQ-KELKIRPD 660
                T       + LT L  + ++  Q+L  ++  I  ++     L + LQ ++ +++  
Sbjct: 1581 GQRETQR-----VALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQ 1635

Query: 661  NELFE 665
             E  E
Sbjct: 1636 REQIE 1640



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 144/676 (21%), Positives = 279/676 (41%), Gaps = 68/676 (10%)

Query: 44   DFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSM 103
            DF +  +   E+L +  +   +    L A+ +  A+    L+  + +LE    + Q  + 
Sbjct: 1116 DFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQ 1175

Query: 104  RKFQEQ----NETFQANRAKMAEGLALALARKDQE---WSEKMDQ-----LEKEKNILTA 151
             + Q Q        Q     + E         D     W  + DQ     L K   +LTA
Sbjct: 1176 AQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTA 1235

Query: 152  QLQEMKNQSMN-LFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELS 210
               E    +++ L Q   +  +     + ++ K++  L   E    ++  EL+   R+LS
Sbjct: 1236 LSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS 1295

Query: 211  RTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQA 270
            + QEE        + L  +L EL    ++L+ +       +  A+ +   L+  ++ L A
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355

Query: 271  LIQQLSI-----------------DLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSG 313
             ++ L                   DL+   +  + K + +   +E+  +L+++ E  ++ 
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415

Query: 314  EEHVQE--LLKEKTLAE-----QNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQAS 366
             + +QE   L  +TLAE     + L    Q+L   R  Q  A+  L   +++  Q +   
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475

Query: 367  EEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTR 426
            +EQ+Q+ +   +  E     +    Q+ +  ++Q   LE+    +   LE Q++ LE+  
Sbjct: 1476 QEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKD 1535

Query: 427  AADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQAL 486
               ++   Q ++ L+++   L+    E E +    + + K +KE   QRE   VA+    
Sbjct: 1536 QMIESQRGQ-VQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLT 1594

Query: 487  EEVRKQREEFQQQAAN----------LTAIIDEKEQNLREKTEVL--LQKEQEIL--QLE 532
             ++ ++ +E Q Q++           L   + E++Q ++ + E +  LQ+++E L   LE
Sbjct: 1595 LDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLE 1654

Query: 533  RGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDL-LRLRG-----PLQAEALSVNES 586
            R     +LQ  ++Q  LE  RT + +      EQ  L LR RG       Q       E 
Sbjct: 1655 RRDQELMLQKERIQV-LEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEG 1713

Query: 587  HVTSRAMQDPVFQLPTAGRTPNGEVGAMD--LTQLQKEKQDLEQQLL-------EKNKTI 637
               S+A +  +  +    R    EV      + +LQ+ K  LEQQL        E +  +
Sbjct: 1714 KGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLL 1773

Query: 638  KQMQQRMLELRKTLQK 653
             Q +Q ++ L++ LQ+
Sbjct: 1774 SQREQEIVVLQQQLQE 1789



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 130/640 (20%), Positives = 273/640 (42%), Gaps = 69/640 (10%)

Query: 47  SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEI---ALEKHQDSSM 103
           S G   + +L  ++   +  + + + +  DY + ++ L++  E LE     L +H+ S  
Sbjct: 272 SQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLS 331

Query: 104 RKFQEQNETFQA-----NRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKN 158
           R  QE+  + Q       +  + EG  +A      + S   + LE + +I +    +  +
Sbjct: 332 RNAQEEKLSLQQVIKDITQVMVEEGDNIA------QGSGHENSLELDSSIFSQFDYQDAD 385

Query: 159 QSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMN 218
           +++ L +       +   ++Q +  ++  L   +E++  ++Q+ +    E    ++ L  
Sbjct: 386 KALTLVR------SVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQK 439

Query: 219 SNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSID 278
                  L+ +  +LQ    +L ++R+ +  ++     ++  LEQ+   L+ +  +L + 
Sbjct: 440 LTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQ 499

Query: 279 LQKVTAETQEKEDVI-------THLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNL 331
                 + +E+++ +         LQE +  LE +  ++LS    ++E L+   L  + L
Sbjct: 500 GDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559

Query: 332 EDTRQQLLAARSSQAKAI-------NTLETRVRELEQTLQASEEQLQQSKGIVAAQETQI 384
              + ++ AA +   ++I       NTL+T V +    L+A+  +L      +A  +  +
Sbjct: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVAD----LRAAAVKLSALNEALALDKVGL 615

Query: 385 -QELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAA---DQTTAEQGMRQL 440
            Q+L    +E+  V  +  A EQ       AL+  +   E+ R A     T  E  +++ 
Sbjct: 616 NQQLLQLEEENQSVCSRMEAAEQ----ARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671

Query: 441 EQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQA 500
           E+  A L+    + +   +  Q   KKL E   Q+E  +  + Q  +E ++Q E      
Sbjct: 672 EEAGAELQADLRDIQEEKEEIQ---KKLSESRHQQEAATTQLEQLHQEAKRQEEV----- 723

Query: 501 ANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEA 560
             L   + EKE  +REK  +    E  +  +ER       Q+  L +  E L +   E  
Sbjct: 724 --LARAVQEKEALVREKAAL----EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE-- 775

Query: 561 AVVAEQEDLLRL-RGPLQAEALSVNES-HVTSRAMQDPVFQLPTAGRTPNGE--VGAMDL 616
               +Q  ++ + +G L+ +  +V ++  V    ++    +L T       E    A  L
Sbjct: 776 --AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQL 833

Query: 617 TQLQKE-KQDLEQQLLEKNKTIKQMQQRMLELRKTLQKEL 655
            Q ++E K  LEQQ     K + Q++++  + R   Q+EL
Sbjct: 834 AQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 138/641 (21%), Positives = 274/641 (42%), Gaps = 70/641 (10%)

Query: 66   QIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLA 125
            +++ +E    D AEQ++ L   KE LE        SS+ + Q+QN   +  + ++   + 
Sbjct: 744  RLQAVERDRQDLAEQLQGLSSAKELLE--------SSLFEAQQQNSVIEVTKGQLEVQIQ 795

Query: 126  LALARKDQ----------EWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRD-----EM 170
                 K+           E   +  Q E+E++    QL + + +     +++      E+
Sbjct: 796  TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEV 855

Query: 171  DELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKL 230
            ++L    ++E S  +  L K  ESL + + ELE R +E    Q+  M + Q   +  +  
Sbjct: 856  NQLREKWEKERSWHQQELAKALESLEREKMELEMRLKE----QQTEMEAIQAQREEERTQ 911

Query: 231  EELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKE 290
             E       LE +++ V   +T  +++   L    Q+L+ L Q + +   K     QE  
Sbjct: 912  AESALCQMQLETEKERVSLLETLLQTQ-KELADASQQLERLRQDMKVQKLK----EQETT 966

Query: 291  DVI-THLQEKVASLEKRLEQNLSGEEHVQE----LLKEKTLAEQNLEDTRQQLLAARSSQ 345
             ++ T LQE    L++   Q+      +QE    LL++K   ++ +ED + QL+A   SQ
Sbjct: 967  GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQ 1026

Query: 346  AKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALE 405
                  ++ ++RE  Q     +++L++ K  +     + ++     QE+  ++QQ L+  
Sbjct: 1027 RLVEQEVQEKLRE-TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSAL 1085

Query: 406  QQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEY--ERSLQNHQF 463
            +Q ++  Q  + ++ A  +     Q   E+    L QE   L+E    +  E+ L+   +
Sbjct: 1086 RQDMQEAQGEQKELSA--QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLW 1143

Query: 464  --ELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVL 521
              E K  + +   R   S   A A E+    + + Q Q A+L + + +   ++ E    L
Sbjct: 1144 AQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPEL 1203

Query: 522  L---QKEQEILQLERGHNSA--------LLQIHQLQAELEALRTLKAEEAAVVAEQEDLL 570
                     +  LE   N A        LL     +A   AL  L  ++     +  D+L
Sbjct: 1204 SGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH-QDLWKTQQTRDVL 1262

Query: 571  RLRGPLQAEALSVNESHVTS--RAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQ 628
            R +     E L+  E+  +     +QD   QL     + N E    + ++ + ++  LE 
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQL-----SQNQE----EKSKWEGKQNSLES 1313

Query: 629  QLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREK 669
            +L+E ++T+  +Q R   LR+   + ++ + + EL +  ++
Sbjct: 1314 ELMELHETMASLQSR---LRRAELQRMEAQGERELLQAAKE 1351



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 156/679 (22%), Positives = 281/679 (41%), Gaps = 136/679 (20%)

Query: 56   LSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQA 115
            L   L + +  +++    L D+ EQ R L++     E+A+E       R+ Q   E    
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEE-----ELAVEG------RRVQALEEVLGD 1891

Query: 116  NRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEG 175
             RA+  E     LA + Q+ +E+  + E E    T  LQ+   Q+  + + RD+  ELE 
Sbjct: 1892 LRAESREQEKALLALQ-QQCAEQAQEHEVE----TRALQDSWLQAQAVLKERDQ--ELEA 1944

Query: 176  FQ--------QQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLS 227
             +        Q+E ++ +   L  +E+LGK    L+ + + L    E   +    ++ L 
Sbjct: 1945 LRAESQSSRHQEEAARARAEAL--QEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQ 2002

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
              L+  Q H   LEE                 AL  +E E+Q    +   D+Q++     
Sbjct: 2003 ASLDACQAHSRQLEE-----------------ALRIQEGEIQDQDLRYQEDVQQLQQALA 2045

Query: 288  EKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAK 347
            ++++ + H QE+   LEK L Q +      + +++EK    QNL   R++         +
Sbjct: 2046 QRDEELRHQQEREQLLEKSLAQRVQ-----ENMIQEK----QNLGQEREE---------E 2087

Query: 348  AINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALE-- 405
             I  L   VREL+ TL   E+++ + +     Q+    E    + ++S +++Q+L L+  
Sbjct: 2088 EIRGLHQSVRELQLTLAQKEQEILELR---ETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144

Query: 406  ----QQFLERTQALEAQIVALE---RTRAADQTTAEQGMRQLEQENAALKECRNEYERSL 458
                Q+ LER QA   Q  A E   R +A D   +   + Q +   ++L+E     + S+
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALS---LAQTKASVSSLQEVAMFLQASV 2201

Query: 459  QNHQFELKKLKEEWS------QREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDE--- 509
                 E ++L++E        ++E +    A +  E+  + E+   Q   ++ +  E   
Sbjct: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ-GVQLGEVSGVEAEPSP 2260

Query: 510  ---KEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQ 566
               ++Q+ R++ E L Q     L+++R      LQ H +Q        L++    V  E+
Sbjct: 2261 DGMEKQSWRQRLEHLQQAVAR-LEIDRSR----LQRHNVQ--------LRSTLEQVERER 2307

Query: 567  EDLLR-LRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQD 625
              L R      QA +L ++++  +S   QD        GR       A  + +LQKE   
Sbjct: 2308 RKLKREAMRAAQAGSLEISKATASSPTQQD--------GRGQKNS-DAKCVAELQKEVVL 2358

Query: 626  LEQQLLEKNKTIK-------QMQQRMLELRKTLQKELKI---------------RPDNEL 663
            L+ QL  + K  +       Q  + +  L  +L   L                 R D  L
Sbjct: 2359 LQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESL 2418

Query: 664  FEVREKPGPEMANMAPSVT 682
             +    PGP + + +PS T
Sbjct: 2419 TQSLTSPGPVLLHPSPSTT 2437


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score =  124 bits (311), Expect = 3e-28
 Identities = 158/712 (22%), Positives = 316/712 (44%), Gaps = 114/712 (16%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKI------KEKLEIALEKHQD 100
            ++  ++++DL S+ + +  +++ L ++L+D     + L++        E+  +  E+   
Sbjct: 509  AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQ 568

Query: 101  SSMRKFQEQNETFQA-------------NRAKMAEGLALALARKDQEWSEKMDQLEKEKN 147
              ++   EQNE  +A             + + +AE L   +A KD++  +  D L  E++
Sbjct: 569  MQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD 628

Query: 148  ILTAQLQEMKN-QSMNLFQRRDEMDELEGFQQQ------ELSKIKHMLLKKEESLGKMEQ 200
             LT++ +E+K+ Q+MN F  + E+ +L+    +      EL K++  +  K++ +  +E+
Sbjct: 629  RLTSKEEELKDIQNMN-FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE 687

Query: 201  ELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYS-----TLEEQRDHVIASKTG-- 253
            +L+    E+S   EE    N  +  L  ++++LQ   S      + EQ +  I  K    
Sbjct: 688  QLQ---HEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL 744

Query: 254  ------AESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRL 307
                   E+ +  +  KE+EL A+  + S  L K   + + K++        V  L+K +
Sbjct: 745  KTVEELLETGLIQVATKEEELNAIRTENS-SLTKEVQDLKAKQNDQVSFASLVEELKKVI 803

Query: 308  EQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLE----------TRVR 357
             +     + V+ELL+ + L   N E T Q L     +  + I  ++          ++V+
Sbjct: 804  HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ 863

Query: 358  ELEQTLQASEEQLQQSKGIVAAQETQ-------IQELAAANQE-SSHVQQQALALEQQFL 409
            EL+  L+  EEQ+   K ++  +E         +Q+L   N+   +HVQ+ A    ++  
Sbjct: 864  ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923

Query: 410  ERTQALEAQIV------------ALERTRAADQTTAEQGMRQLEQEN-------AALKEC 450
              +Q  E +IV            A+ + R +D ++  Q ++ ++ EN         LK+ 
Sbjct: 924  SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 983

Query: 451  RNEYERSLQNHQFELKKLKEEWSQREIVSV-----AMAQALEEVRKQREEFQQQAANLTA 505
              +   S   H+  LK + E   ++EI  +     ++  A+E  RK+  E QQQ   +  
Sbjct: 984  NYQQASSFPPHEELLKVISER--EKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVEL 1041

Query: 506  IIDEKEQNLREKTEV------------LLQKEQEILQLERGHNSALLQIHQLQA--ELEA 551
               E  + L  K  V              +K +E +    G     +  H+L+   E+  
Sbjct: 1042 EAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHT 1101

Query: 552  LRTLKAEE-AAVVAEQEDLL-RLRGPLQAE----ALSVNESHVTSRAMQDPVFQLPTAGR 605
            L  L+ E+  +V+AE E +L +L+  ++ E     + V+ESH T + MQ           
Sbjct: 1102 LLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE 1161

Query: 606  TPNGEVGAMDLTQLQKEKQDLEQQL----LEKNKTIKQMQQRMLELRKTLQK 653
                E    D+  L++E++ LE +L    +E++  + ++++   +L +TL K
Sbjct: 1162 RLRSE--NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTK 1211



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 122/619 (19%), Positives = 264/619 (42%), Gaps = 75/619 (12%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQE----Q 109
            E +   +  ++E+++ +E  L     QV      KE+   A+     S  ++ Q+    Q
Sbjct: 731  EQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAIRTENSSLTKEVQDLKAKQ 786

Query: 110  NETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
            N+  Q + A + E L   +  KD +     + LE E   +  + + +++    +   ++E
Sbjct: 787  ND--QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEE 844

Query: 170  MDELEGFQQQELS------KIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS 223
            +  ++  + Q+LS      +++++L  KEE +  M+  LE + ++L+ T + L       
Sbjct: 845  IGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ------ 898

Query: 224  SDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVT 283
             DL ++ E L+ H   + +      +S +  E     L++KE EL+ L   L      ++
Sbjct: 899  -DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 957

Query: 284  AETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARS 343
            ++TQ  +DV    Q++    + ++EQ           LK++   + +     ++LL   S
Sbjct: 958  SKTQLLQDV----QDENKLFKSQIEQ-----------LKQQNYQQASSFPPHEELLKVIS 1002

Query: 344  SQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALA 403
             + K I+ L   +  L+  ++      Q+ K     Q+ +  EL A         + ++ 
Sbjct: 1003 EREKEISGLWNELDSLKDAVEH-----QRKKNNERQQQVEAVELEAKEVLKKLFPKVSVP 1057

Query: 404  LEQQFLERTQALE--AQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNH 461
                + E     E  A+      + + +    E  +++ ++ +  L+    +Y+  L   
Sbjct: 1058 SNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET 1117

Query: 462  QFELKKLKEEWSQREIV-SVAMAQALEEVRKQREEFQQQAANLTAIIDEKE--QNLREKT 518
            +  L+KL+    Q E    V + ++ + +++ +  F      L  +  E +  +NLR + 
Sbjct: 1118 EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER 1177

Query: 519  EVLLQKEQEILQLERGHNSALLQIHQLQAEL-EALRTLKAEEAAVVAEQEDLLRLRGPLQ 577
            E L   E E+ + E   ++ + ++ +L+A+L E L  L+        EQ +  ++ G L 
Sbjct: 1178 EHL---EMELEKAEMERSTYVTEVRELKAQLNETLTKLR-------TEQNERQKVAGDLH 1227

Query: 578  --AEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNK 635
               ++L + +S +   A    V +        N +V        + E  + E   +  N+
Sbjct: 1228 KAQQSLELIQSKIVKAAGDTTVIE--------NSDVSP------ETESSEKETMSVSLNQ 1273

Query: 636  TIKQMQQRMLELRKTLQKE 654
            T+ Q+QQ +  + + L KE
Sbjct: 1274 TVTQLQQLLQAVNQQLTKE 1292



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 132/667 (19%), Positives = 270/667 (40%), Gaps = 77/667 (11%)

Query: 41  SGDDFASDGSSSRED--LSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKH 98
           +G+   SD  S   D  LS  L   ++Q+  +   + + +  VR  +K ++K +  LE+ 
Sbjct: 69  NGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQ 128

Query: 99  --QDSSMRKFQEQN-ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQE 155
             ++S   K   +  E     +       A A  +K  +   K    +++K + T  +  
Sbjct: 129 VIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPS 188

Query: 156 MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEE 215
            + +++ L Q   E  +  G  +++ S  K    +K E++   E  + A T         
Sbjct: 189 KRQEALPLHQ---ETKQESGSGKKKASSKK----QKTENVFVDEPLIHATT------YIP 235

Query: 216 LMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL 275
           LM+ N  SS +  K E +      L+  +   I  K+G +   T  +++  E++   +  
Sbjct: 236 LMD-NADSSPVVDKREVID----LLKPDQVEGI-QKSGTKKLKTETDKENAEVK--FKDF 287

Query: 276 SIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGE-----EHVQELLKEKTLAEQN 330
            + L+ +     E   V+  L+EK   ++  L+++  GE       +QE  K+K LA   
Sbjct: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQE--KDKLLAAVK 345

Query: 331 -----LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQ 385
                 +D  +QL     ++ +  N + TR+++   TL+  E  + Q+K  V+ QETQ  
Sbjct: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE-KEHNVFQNKIHVSYQETQQM 404

Query: 386 ELA------AANQESSHVQQQ------ALALEQQFLERTQALEAQIVALERTRAADQTT- 432
           ++           E +H++Q+      A++     LE  Q+ E   +  +  R  ++ T 
Sbjct: 405 QMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTE 464

Query: 433 --------------AEQGMR----QLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQ 474
                         AEQ       QL++     +E ++   +    H+   + L+ ++  
Sbjct: 465 KTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVA 524

Query: 475 REIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERG 534
           +E    ++   L +    +++ +Q+   L     E EQ    K E L  + Q+IL+    
Sbjct: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLM----ESEQKRVNKEESLQMQVQDILEQNEA 580

Query: 535 HNSALLQIHQLQAELEALRTLKAEEAAVVAEQE-DLLRLRGPLQAEALSVNESHVTSRAM 593
             + + Q H   A   +   L  E   V+AE++  + +    L +E   +       + +
Sbjct: 581 LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDI 640

Query: 594 QDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
           Q+  F L         +  A +      E + ++Q +  K+  I+ +++++        +
Sbjct: 641 QNMNFLL--KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698

Query: 654 ELKIRPD 660
           E KI  D
Sbjct: 699 EFKILND 705



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 72/312 (23%), Positives = 133/312 (42%), Gaps = 30/312 (9%)

Query: 74   LSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQ 133
            +S+  +++  L    + L+ A+E HQ     + Q+Q E  +    ++ + L   ++    
Sbjct: 1001 ISEREKEISGLWNELDSLKDAVE-HQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSN 1059

Query: 134  ----EWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLL 189
                EW    ++  KE    T+  +E+K     L  +  E DE+    Q E  K K +L 
Sbjct: 1060 LSYGEWLHGFEKKAKECMAGTSGSEEVKV----LEHKLKEADEMHTLLQLECEKYKSVLA 1115

Query: 190  KKEESLGKMEQELEARTRELS-RTQEELMNSNQMSSDLSQKLEELQRHYS------TLEE 242
            + E  L K+++ +E    +   +  E      QM S  +   +EL+R  S       L  
Sbjct: 1116 ETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR 1175

Query: 243  QRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVAS 302
            +R+H+      AE + +    + +EL+A   QL+  L K+  E  E++ V   L +   S
Sbjct: 1176 EREHLEMELEKAEMERSTYVTEVRELKA---QLNETLTKLRTEQNERQKVAGDLHKAQQS 1232

Query: 303  LEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQT 362
            LE  L Q+   +      + E +      E + ++ ++   +Q          V +L+Q 
Sbjct: 1233 LE--LIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQT---------VTQLQQL 1281

Query: 363  LQASEEQLQQSK 374
            LQA  +QL + K
Sbjct: 1282 LQAVNQQLTKEK 1293



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 52/240 (21%), Positives = 107/240 (44%), Gaps = 35/240 (14%)

Query: 87   IKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEK 146
            ++ KL+ A E H  + ++   E+ ++  A    + + L  ++ +++ +W  K+D+  K  
Sbjct: 1089 LEHKLKEADEMH--TLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK-- 1144

Query: 147  NILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEART 206
                     +K    +      E++ L    + E   I+++  ++E     +E ELE   
Sbjct: 1145 --------TIKQMQSSFTSSEQELERL----RSENKDIENLRREREH----LEMELEKAE 1188

Query: 207  RELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQ 266
             E S    E+    ++ + L++ L +L+    T + +R  V      A+  +  ++ K  
Sbjct: 1189 MERSTYVTEV---RELKAQLNETLTKLR----TEQNERQKVAGDLHKAQQSLELIQSK-- 1239

Query: 267  ELQALIQQLSIDLQKVTAETQ--EKEDVITHLQEKVASLEKRLE---QNLSGE-EHVQEL 320
             ++A      I+   V+ ET+  EKE +   L + V  L++ L+   Q L+ E EH Q L
Sbjct: 1240 IVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1299


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  123 bits (309), Expect = 6e-28
 Identities = 160/716 (22%), Positives = 313/716 (43%), Gaps = 95/716 (13%)

Query: 6    KKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRN- 64
            K+K A E  V       T +  ++SK +              D     ED  + L++ N 
Sbjct: 970  KEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINA 1029

Query: 65   ---EQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSM----------RKFQEQNE 111
               +Q   LE  L    +   +L++ K KLE  L+  Q+S M           K +++  
Sbjct: 1030 KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEF 1089

Query: 112  TFQANRAKMAEGL--ALALARKDQEWSEKMDQLEKE---KNILTAQLQEMKNQ-SMNLFQ 165
                 +AK+ +    +L   +K +E   ++++LE+E   ++ L A++++ ++  +  L +
Sbjct: 1090 ELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEE 1149

Query: 166  RRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS-S 224
              + ++E  G    ++   K    K+E    KM ++LE  T +   T   L      S +
Sbjct: 1150 ISERLEEASGATSAQIEMNK----KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVA 1205

Query: 225  DLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTA 284
            +L ++++ LQR    LE+++  +        S I AL + +  ++   + +     ++ A
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA 1265

Query: 285  ETQEKEDVI-------THLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQ 337
            + +++  +I         LQ +   L  R+E+    E  + +L K K    Q LE+ ++Q
Sbjct: 1266 KDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK---ESLISQLTKSKQALTQQLEELKRQ 1322

Query: 338  L---LAARSSQAKAINT-------LETRVRELEQTLQASEEQLQQSKGIVAAQETQIQEL 387
            +     A+++ A A+ +       L  +  E ++     +  L ++   VA   T+ +  
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382

Query: 388  AAANQESSHVQQQALALE-QQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAA 446
            A    E     ++ LA   Q+  E T+   ++  +LE+T+   Q   E  MR LE+ + A
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442

Query: 447  L----KECRN------EYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEV------- 489
                 K+ RN      E+++ L   Q EL+  ++E          M  A EEV       
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502

Query: 490  RKQREEFQQQAANLTAIIDEKEQNLR--EKTEVLLQKEQEILQLERGHNSALLQIHQ--- 544
            R++ +  Q++ ++LT  I E  +NL+  EKT+ L+++E+  LQ+        L+  +   
Sbjct: 1503 RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKI 1562

Query: 545  LQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQ--AEAL-SVNESHVTSRAMQDPVFQLP 601
            L+ +LE  +     +  V+ + E++ +L+   Q  AEAL SV ++ + SR          
Sbjct: 1563 LRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSR---------- 1612

Query: 602  TAGRTPNGEVGAMDLTQLQKEKQ-DLEQQLLEKNKTIKQMQQRMLELRKTLQKELK 656
                         D  +L+K+ + DL +  ++   + +QM +    LR T+Q +LK
Sbjct: 1613 ------------NDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLR-TVQGQLK 1655



 Score =  107 bits (267), Expect = 4e-23
 Identities = 162/714 (22%), Positives = 297/714 (41%), Gaps = 111/714 (15%)

Query: 43   DDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSS 102
            +D  S      +DL   L +  ++    E ++ + +E++  L++   KL     K + S 
Sbjct: 948  EDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLT----KEKKSL 1003

Query: 103  MRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMN 162
                Q+  +  Q    K+  GL    A+ +Q+  +    LE+EK  L A L+  K +   
Sbjct: 1004 QEAHQQTLDDLQVEEDKV-NGLIKINAKLEQQTDDLEGSLEQEKK-LRADLERAKRK--- 1058

Query: 163  LFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQM 222
                      LEG    +L   +  ++  E    ++E++L+ +  ELS+ Q ++ +    
Sbjct: 1059 ----------LEG----DLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVH 1104

Query: 223  SSDLSQKLEELQRHYSTLEE--QRDHVIASKTGAESKITALEQKE--------------- 265
            S    +K++ELQ     LEE  + +H + +K   +    A E +E               
Sbjct: 1105 SLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQ 1164

Query: 266  ----QELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHV-QEL 320
                ++ +A  Q++  DL++ T    + E     L++K A     L + +   + V Q+L
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATL---QHEATAATLRKKQADSVAELGEQIDNLQRVKQKL 1221

Query: 321  LKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQ 380
             KEK+  +  ++D    + A   S++    T  T V +    ++A +EQ  Q   ++   
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRT-VEDQFSEIKAKDEQQTQ---LIHDL 1277

Query: 381  ETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQL 440
              Q   L   N E SH  ++  +L  Q  +  QAL  Q+  L+R +  ++T A+  M   
Sbjct: 1278 NMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR-QMEEETKAKNAMAHA 1336

Query: 441  EQENA----ALKECRNEYERSLQNHQFELKKLKEEWSQ----REIVSVAMAQALEEVRKQ 492
             Q +      L+E   E + +    Q  L K   E +Q     E  ++   + LEE +K+
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396

Query: 493  REEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEIL--QLERGHNSALL---------- 540
              +  Q+A   T   + K  +L EKT+  LQ E E L   LER H +             
Sbjct: 1397 LAQRLQEAEENTETANSKCASL-EKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDK 1455

Query: 541  -------QIHQLQAELEAL----RTLKAE-------EAAVVAEQEDLLRLRGPLQAE--- 579
                   ++ + QAELEA     R+L  E          VV + E L R    LQ E   
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515

Query: 580  --------ALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMD------LTQLQKEKQD 625
                      ++ E+  T + ++     L  A     G +   +        +L + K +
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE 1575

Query: 626  LEQQLLEKNKTIKQMQQRMLELRKTLQKEL--KIRPDNELFEVREKPGPEMANM 677
            L+++++EK++ I+Q+++      + LQ  L  +IR  N+   +++K   ++  M
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEM 1629



 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 114/563 (20%), Positives = 250/563 (44%), Gaps = 93/563 (16%)

Query: 156  MKNQSMNLFQRRDEMDELEGFQQQELSKIKHM-----------LLKKEESLGKMEQELEA 204
            M+ +   + +RRD +  ++ +  +    +KH            LLK  E+    E+E+  
Sbjct: 801  MRVEFKKMMERRDSIFCIQ-YNIRSFMNVKHWPWMNLFFKIKPLLKSAEA----EKEMAT 855

Query: 205  RTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQK 264
               +  RT+EEL  S     +L +K+  L +  + L+ Q      +   AE +   L + 
Sbjct: 856  MKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKS 915

Query: 265  EQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEK 324
            +  L+A +++L+  L++      E      +L++K +SL++ ++     E  + ++ KEK
Sbjct: 916  KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL---ELTLTKVEKEK 972

Query: 325  TLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQI 384
               E  +++  +++ A           LE  + +L +  ++ +E  QQ+   +  +E ++
Sbjct: 973  HATENKVKNLSEEMTA-----------LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKV 1021

Query: 385  QELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQEN 444
              L   N   + ++QQ   LE   LE+ + L A +   +R    D   +++ +  LE + 
Sbjct: 1022 NGLIKIN---AKLEQQTDDLEGS-LEQEKKLRADLERAKRKLEGDLKMSQESIMDLEND- 1076

Query: 445  AALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQ------ 498
                  + + E  L+  +FEL +L+ +    ++ S+   + ++E++ + EE ++      
Sbjct: 1077 ------KQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH 1130

Query: 499  --------QAANLTAIIDEKEQNLRE-------KTEVLLQKEQEILQLERGHNSALLQIH 543
                    Q ++L   ++E  + L E       + E+  ++E E  ++ R    A L   
Sbjct: 1131 TLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATL--- 1187

Query: 544  QLQAELEALRTLKAEEAAVVAEQ-EDLLRLRGPLQ----------------AEALSVNES 586
            Q +A    LR  +A+  A + EQ ++L R++  L+                 EALS ++S
Sbjct: 1188 QHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247

Query: 587  HV--TSRAMQDPVFQLPTAGRTPNGEVGAMDL--TQLQKEKQDLEQQLLEKNKTIKQ--- 639
            ++  T R ++D   ++          +  +++   +LQ +  +L  ++ EK   I Q   
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307

Query: 640  ----MQQRMLELRKTLQKELKIR 658
                + Q++ EL++ +++E K +
Sbjct: 1308 SKQALTQQLEELKRQMEEETKAK 1330



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 141/684 (20%), Positives = 286/684 (41%), Gaps = 82/684 (11%)

Query: 27   RSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSD---YAEQVRN 83
            R   KES+ S    S           +  +  +   +N     L++   D     EQ   
Sbjct: 1294 RVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEE 1353

Query: 84   LQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSE------ 137
             Q+ K +L+ AL K  +S + +++ + ET    R +  E     LA++ QE  E      
Sbjct: 1354 EQEAKAELQRALSK-ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETAN 1412

Query: 138  -KMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLG 196
             K   LEK K  L  +++++             +D+    +Q+   K+   L + ++ L 
Sbjct: 1413 SKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDK----KQRNFDKV---LAEWKQKLD 1465

Query: 197  KMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAES 256
            + + ELEA  +E      EL        ++  +LE L+R    L+E+   +         
Sbjct: 1466 ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK 1525

Query: 257  KITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQN-LSGEE 315
             +   E+ ++ ++     L + L++V    + +E  I  +Q +++ ++  L++  +  +E
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585

Query: 316  HVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKG 375
             +++L +    A + L+      + +R+   +    +E  + E+E  L  S  Q+ +++ 
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQK 1645

Query: 376  IVAAQETQIQE----LAAANQESSHVQQQALALEQQ---FLERTQALEAQIVALERTRAA 428
             +   + Q+++    L  A + +  +++Q   +E++    LE  + ++  +   ERTR  
Sbjct: 1646 HLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRL 1705

Query: 429  DQ---TTAEQGMRQLEQENAALKECRNEYERSLQNHQFELK------KLKEEWSQREIVS 479
             +     A   ++ L  +N +L   + + E  +   Q E++      +  EE +++ I  
Sbjct: 1706 SEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITD 1765

Query: 480  VAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSAL 539
             AM    EE++K+    Q  +A+L  +    EQ +++    L + EQ  L L+ G     
Sbjct: 1766 AAM--MAEELKKE----QDTSAHLERMKKNLEQTVKDLQHRLDEAEQ--LALKGGKK--- 1814

Query: 540  LQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQ 599
             QI +L+  +  L             + D+ + RG   AEAL    +H   R +++  +Q
Sbjct: 1815 -QIQKLENRVRELE-----------NELDVEQKRG---AEAL--KGAHKYERKVKEMTYQ 1857

Query: 600  LPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRP 659
                      E    ++ +L    QDL  +L  K K+ K+  +   E   T     + R 
Sbjct: 1858 ---------AEEDHKNILRL----QDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCR-RV 1903

Query: 660  DNELFEVREKPGPEMANMAPSVTN 683
             +EL E  E+     A++A S  N
Sbjct: 1904 QHELEEAAER-----ADIAESQVN 1922



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 133/631 (21%), Positives = 275/631 (43%), Gaps = 107/631 (16%)

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMA 121
            R  E++ + EAR  +  E++ +L + K  L++ ++   ++ M            +  +  
Sbjct: 862  RTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM------------DAEERC 909

Query: 122  EGLA---LALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQ 178
            EGL    + L  K +E +E++++ E+  + L A+ + ++++  +L   + ++D+LE    
Sbjct: 910  EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL---KRDIDDLE---- 962

Query: 179  QELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQR-HY 237
                           +L K+E+E  A   ++    EE+    +  S L+++ + LQ  H 
Sbjct: 963  --------------LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQ 1008

Query: 238  STLEEQRDHVIASKTGAESKITA-LEQKEQELQALIQQ---LSIDLQ----KVTAETQEK 289
             TL++ +  V   K     KI A LEQ+  +L+  ++Q   L  DL+    K+  + +  
Sbjct: 1009 QTLDDLQ--VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMS 1066

Query: 290  EDVITHLQEKVASLEKRLE---------QNLSGEEHVQELLKEKTLAE--QNLEDTRQQL 338
            ++ I  L+     +E++L+         Q    +E V  L  +K + E    +E+  +++
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI 1126

Query: 339  LAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQ-------ETQIQELAAAN 391
             A  + +AK    +E +  +L + L+   E+L+++ G  +AQ       E + Q++    
Sbjct: 1127 EAEHTLRAK----IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDL 1182

Query: 392  QESSHVQQQALA--LEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKE 449
            +E++ +Q +A A  L ++  +    L  QI  L+R +       E+   +L+ E   +  
Sbjct: 1183 EEAT-LQHEATAATLRKKQADSVAELGEQIDNLQRVK----QKLEKEKSELKMEIDDMAS 1237

Query: 450  CRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDE 509
                  +S  N +   + +++++S+ +       Q + ++  Q+   Q Q   L+  ++E
Sbjct: 1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297

Query: 510  KE---QNLREKTEVLLQKEQEI-LQLERGHNSALLQIHQLQA---ELEALRTLKAEEAAV 562
            KE     L +  + L Q+ +E+  Q+E    +     H LQ+   + + LR    EE   
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357

Query: 563  VAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKE 622
             AE +            ALS   S V   A     ++     RT           +L++ 
Sbjct: 1358 KAELQ-----------RALSKANSEV---AQWRTKYETDAIQRT----------EELEEA 1393

Query: 623  KQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
            K+ L Q+L E  +  +    +   L KT Q+
Sbjct: 1394 KKKLAQRLQEAEENTETANSKCASLEKTKQR 1424


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score =  122 bits (307), Expect = 1e-27
 Identities = 167/722 (23%), Positives = 312/722 (43%), Gaps = 82/722 (11%)

Query: 41   SGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQD 100
            S D+   D       L SQL +   +   L ++L     ++ +LQ +++  +  L   Q+
Sbjct: 528  SKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQE 587

Query: 101  SSMRKFQEQN--ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKN 158
            + +R   E    +  Q  +A + E L L      Q+ +E   +  KEK  + AQLQ ++ 
Sbjct: 588  ARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIE- 646

Query: 159  QSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMN 218
                     D +D+   F Q + +K              +E++L+ R  E    +E L  
Sbjct: 647  --------ADMLDQEAAFMQIQEAKTM------------VEEDLQRRLEEFEGERERLQR 686

Query: 219  SNQMSSDLSQKLEE-----LQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQAL-- 271
                ++ L Q+LE+     LQR       Q++H+   K    ++  AL+ +EQ L AL  
Sbjct: 687  MADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQ-EALQSREQSLDALQT 745

Query: 272  -IQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQN 330
               +L   L ++  E   +ED I  LQ +   LE  L+   SG+E +    +      + 
Sbjct: 746  HYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEE 805

Query: 331  LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAA 390
              +T ++L    + ++  +  L+     L++ +Q  +EQ  Q K +V A     ++  + 
Sbjct: 806  TSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYR---RDATSK 862

Query: 391  NQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAAL--- 447
            +Q  S ++     L+ +  E  Q L  Q+   +RT  A+ +   + + Q+ Q  A L   
Sbjct: 863  DQLISELKATRKRLDSELKELRQEL-MQVHGEKRTAEAELSRLHREVAQVRQHMADLEGH 921

Query: 448  ----KECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANL 503
                ++ R+E E  LQ+ QF+ +++           VA+ +A E ++KQ EE QQ+A   
Sbjct: 922  LQSAQKERDEMETHLQSLQFDKEQM-----------VAVTEANEALKKQIEELQQEARK- 969

Query: 504  TAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSAL-LQIHQLQAELEALRTLKAEEAAV 562
               I E++Q +R     L   ++E+    + + +A+ +   +LQ   EAL   +A +A +
Sbjct: 970  --AITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQ---EALAAKEAADAEL 1024

Query: 563  VAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKE 622
                   LR +G     +L+++E      A    V    T       EV A+   +L++ 
Sbjct: 1025 -----GQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEES 1079

Query: 623  KQ---DLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAP 679
            ++   +LE + L++++  ++  +R+ E  K L  EL+        E  +  G   +N A 
Sbjct: 1080 REKVLELEDE-LQESRGFRKKIKRLEESNKKLALELE-------HEKGKLTGLGQSNAAL 1131

Query: 680  SVTNNTDLT-----DAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENML 734
               N+   T     +A  +        VL+     + +  HL++A+   L   +E+ N L
Sbjct: 1132 REHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSL 1191

Query: 735  KE 736
            KE
Sbjct: 1192 KE 1193



 Score =  104 bits (259), Expect = 4e-22
 Identities = 143/627 (22%), Positives = 279/627 (44%), Gaps = 83/627 (13%)

Query: 66   QIRKLEARLSDYAEQVRNLQKIKEKLEIALE------KHQDSSMRKFQEQNETFQANRAK 119
            ++ +L+   +   + +  LQ  K  LE AL+      +  D   R+ +E  E       K
Sbjct: 753  RLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEK 812

Query: 120  MAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQ 179
            + E LA+         S +++ L++E   L  Q+Q++K Q +      +        + Q
Sbjct: 813  LREELAIK--------SGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQ 864

Query: 180  ELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYST 239
             +S++K    + +  L ++ QEL     E    + EL   ++  + + Q + +L+ H  +
Sbjct: 865  LISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQS 924

Query: 240  LEEQRDHV---IASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHL 296
             +++RD +   + S    + ++ A+ +  + L+  I++L  + +K   E ++K   +  L
Sbjct: 925  AQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQK---MRRL 981

Query: 297  QEKVASLEKRLEQNLSGEEHVQELLK---EKTLAEQNLEDTRQQLLAARSSQAKAINTLE 353
               + S +K ++      E+   +L    ++ LA +   D     L A+   + +   L 
Sbjct: 982  GSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALH 1041

Query: 354  TRVRELEQTLQASEEQLQQSKGIVAAQETQIQE-LAAANQESSHVQQQALALEQQFLERT 412
             R++ LE  LQA    +  SK ++   E ++QE +A  +QE    +++ L LE + L+ +
Sbjct: 1042 ERIQALEAELQA----VSHSKTLL---EKELQEVIALTSQELEESREKVLELEDE-LQES 1093

Query: 413  QALEAQIVALERT--RAADQTTAEQG-MRQLEQENAALKECRNEYERSLQNHQFELKKL- 468
            +    +I  LE +  + A +   E+G +  L Q NAAL+E  +  E +L   + +L +L 
Sbjct: 1094 RGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLN 1153

Query: 469  ----------KEEWSQREIVSVAMAQALEEVRKQREEFQQQ----------------AAN 502
                      +EE  Q + +  A+  +LE+ +++    ++Q                AA+
Sbjct: 1154 LQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAAS 1213

Query: 503  LTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAV 562
            L     +KE   +E     LQ E + LQ+  G +S   +I Q QAEL             
Sbjct: 1214 LELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQ--EIAQFQAEL------------- 1258

Query: 563  VAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKE 622
             AE    L+L      E LS  +  V ++ M++  +++    R        +DLT+ Q+ 
Sbjct: 1259 -AEARAQLQLLQKQLDEQLS--KQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTE-QQG 1314

Query: 623  KQDLE--QQLLEKNKTIKQMQQRMLEL 647
            +++LE  QQLL+  K+  +M Q  L +
Sbjct: 1315 RKELEGLQQLLQNVKSELEMAQEDLSM 1341



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 141/637 (22%), Positives = 264/637 (41%), Gaps = 107/637 (16%)

Query: 78  AEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSE 137
           A+ +     IK+ L+ A  +HQD      QE N   ++ R  +   ++L  +  + +  E
Sbjct: 352 ADTLGQFPSIKDVLQAAAAEHQDQG----QEVNGEVRSRRDSICSSVSLESSAAETQ--E 405

Query: 138 KMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMD--------------ELEGFQQQ---- 179
           +M Q+ KEK  L  QL+ +  ++    + + E+               E     QQ    
Sbjct: 406 EMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDS 465

Query: 180 ---ELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRH 236
              E+  +K      E ++  ++  LEA+   L+ +  +L  + +    L  K+E++QR 
Sbjct: 466 LSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQR- 524

Query: 237 YSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHL 296
                        S    ++ +  L Q+   LQ+ +QQ+ ++   +T++ +  +  I+ L
Sbjct: 525 -------------SMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSL 571

Query: 297 QEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRV 356
           Q    S+ +  +Q L+       L +E   A   L+     +   + +QA  +  L+   
Sbjct: 572 Q----SVRQWYQQQLA-------LAQE---ARVRLQGEMAHIQVGQMTQAGLLEHLKLEN 617

Query: 357 RELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESS--HVQQQALALEQQFLERTQA 414
             L Q L  ++ +  + KG +AAQ   I E    +QE++   +Q+    +E+    R + 
Sbjct: 618 VSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAFMQIQEAKTMVEEDLQRRLEE 676

Query: 415 LEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKL---KEE 471
            E +   L+  R AD   + +  +QLEQ    L +   + E   Q H   +K+L   +E 
Sbjct: 677 FEGERERLQ--RMADSAASLE--QQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEA 732

Query: 472 WSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEIL-- 529
              RE    A+    +E++ +  E Q +AA+            RE T  LLQ E+ IL  
Sbjct: 733 LQSREQSLDALQTHYDELQARLGELQGEAAS------------REDTICLLQNEKIILEA 780

Query: 530 ----------QLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQ-EDLLRLRGPLQA 578
                     +L+RG         +    LE LR    EE A+ + Q E L +    L+ 
Sbjct: 781 ALQAAKSGKEELDRGARRLEEGTEETSETLEKLR----EELAIKSGQVEHLQQETAALKK 836

Query: 579 EALSVNESHVTSRAMQDP-----------VFQLPTAGRTPNGEVGAM--DLTQLQKEKQD 625
           +   + E  +  + M +            + +L    +  + E+  +  +L Q+  EK+ 
Sbjct: 837 QMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRT 896

Query: 626 LEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNE 662
            E +L   ++ + Q++Q M +L   LQ   K R + E
Sbjct: 897 AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEME 933



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 89/426 (20%), Positives = 185/426 (43%), Gaps = 49/426 (11%)

Query: 53   REDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEK-LEIALEKHQDSSMRKFQEQNE 111
            +++    +  + +++R+L + L+   ++++   K  E  + I   + Q++   K     E
Sbjct: 964  QQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAE 1023

Query: 112  TFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEM-KNQSMNLFQRRDEM 170
              Q      +   +LAL  + Q    ++  +   K +L  +LQE+    S  L + R+++
Sbjct: 1024 LGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKV 1083

Query: 171  DELEGFQQQELSKIKHMLLKKEESLGKMEQELE-------------ARTRE--------L 209
             ELE  + QE    +  + + EES  K+  ELE             A  RE        L
Sbjct: 1084 LELED-ELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETAL 1142

Query: 210  SRTQEELMNSN-QMSSDLSQKLEE-------LQRHYSTLEEQRDHVIASKTGAESKITAL 261
            ++ + +L+  N Q+ + L +K EE       +Q   ++LE++++ V + K     ++ A 
Sbjct: 1143 AKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLK----EQVAAA 1198

Query: 262  EQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELL 321
            + +    +   +  S++L +V  E Q KE ++  LQ +   L+ R  ++       Q  L
Sbjct: 1199 KVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAEL 1258

Query: 322  KEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQL--------QQS 373
             E     Q L+    + L+ +    + +  L+  V + E+ +Q+ ++QL        ++ 
Sbjct: 1259 AEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKEL 1318

Query: 374  KGIVAAQETQIQELAAANQESSHVQQQALALEQQFLE-----RTQALEAQIVALERTRAA 428
            +G+    +    EL  A ++ S  Q+    L+ +  E     +T   + Q + L+  R A
Sbjct: 1319 EGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGA 1378

Query: 429  DQTTAE 434
             +T  E
Sbjct: 1379 AKTRKE 1384


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  121 bits (304), Expect = 2e-27
 Identities = 133/654 (20%), Positives = 295/654 (45%), Gaps = 64/654 (9%)

Query: 25   IPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNL 84
            + +S SK S  +    + +    D     ++ + Q L  + +++++E   + + EQ+   
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348

Query: 85   QKIKEKLE--IALEKHQDSSMRKFQEQN----ETFQANRAKMAEGLALALARKDQEWSEK 138
            ++ K  LE  IA    Q + M+K  E +    ET +  + K+ + L   L+++ +E    
Sbjct: 1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE-GLSQRHEEKVAA 1407

Query: 139  MDQLEKEKNILTAQLQEM-------KNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKK 191
             D+LEK K  L  +L ++       +  + NL +++ + D+L       L++ K +  K 
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL-------LAEEKTISAKY 1460

Query: 192  EESLGKME---QELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVI 248
             E   + E   +E E +   L+R  EE M           +LE L + + T   + + ++
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKA-------ELERLNKQFRT---EMEDLM 1510

Query: 249  ASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLE 308
            +SK      +  LE+ ++ L+  ++++   L+++  E Q  ED    L+  + +++ + E
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570

Query: 309  QNLSG-----EEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTL 363
            ++L G     EE  ++L+++    E  LED R+Q    RS    A   LE  +++LE  +
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ----RSMAVAARKKLEMDLKDLEAHI 1626

Query: 364  QASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALE 423
             ++ +   ++   +   + Q+++      ++   +++ LA  ++  ++ +++EA+++ L+
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686

Query: 424  RTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMA 483
               AA    AE+  RQ +QE       R+E    + N   +     EE  + E     + 
Sbjct: 1687 EELAA----AERAKRQAQQE-------RDELADEIANSSGKGALALEEKRRLEARIAQLE 1735

Query: 484  QALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIH 543
            + LEE +   E    +       ID+   +L  +     + E    QLER +    +++ 
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795

Query: 544  QLQAELEA--LRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLP 601
            +++  +++    ++ A EA +   +E L       QA    V     T + ++D + Q+ 
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRR---TEKKLKDVLLQVD 1852

Query: 602  TAGRT-----PNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKT 650
               R         +  +  L QL+++ ++ E++    N + +++Q+ + +  +T
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATET 1906



 Score =  105 bits (263), Expect = 1e-22
 Identities = 134/660 (20%), Positives = 290/660 (43%), Gaps = 73/660 (11%)

Query: 55   DLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQ------DSSMRKFQE 108
            DL +++    E+ + L+A      + ++ L++  E+ E A +K Q      ++ ++K +E
Sbjct: 919  DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE 978

Query: 109  QNETFQANRAKMAEGLALALARKDQ------EWSEKMDQLEKEKNILTAQLQEMKNQSMN 162
            +    +    K+A+   L   R  +      E  EK   L K KN   A + +++ +   
Sbjct: 979  EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR 1038

Query: 163  LFQRRDEMD----ELEGFQ---QQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEE 215
              ++R E++    +LEG       ++++++  + + +  L K E+EL+A    L+R +EE
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA---ALARVEEE 1095

Query: 216  LMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL 275
                N       +K+ EL+   S L+E  +   AS+  A       E+++++L   ++ L
Sbjct: 1096 AAQKNM----ALKKIRELESQISELQEDLESERASRNKA-------EKQKRDLGEELEAL 1144

Query: 276  SIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNL-SGEEHVQELLKEKTLAEQNLEDT 334
              +L+     T  ++++ +  +++V  L+K LE+   + E  +QE+ ++ + A + L + 
Sbjct: 1145 KTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ 1204

Query: 335  RQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQES 394
             +Q    +++  KA  TLE    EL   ++   +    S+      E Q+QEL     E 
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264

Query: 395  SHVQ---------------------QQALALEQQFLERTQALEAQI---VALERTRAADQ 430
              V+                      Q+ +   +  +   ALE+Q+     L +     +
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324

Query: 431  TTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVR 490
             +    ++Q+E E  + +E   E E +  N + ++  L  + +  +         LE   
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384

Query: 491  KQREEFQQQAANLTAIIDEK--EQNLREKTEVLLQKEQEILQLERGH-NSALLQIHQLQA 547
            + + + Q+    L+   +EK    +  EKT+  LQ+E + L ++  H   +   + + Q 
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444

Query: 548  ELEALRTLKAEEAAVVAEQEDLLRLRG-PLQAEALSVNESHVTSRAMQDPVFQLPTAGRT 606
            + + L   +   +A  AE+ D         + +ALS+      +RA+++ + Q     R 
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL------ARALEEAMEQKAELERL 1498

Query: 607  PNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELR---KTLQKELKIRPDNEL 663
               +    ++  L   K D+ + + E  K+ + ++Q++ E++   + L+ EL+   D +L
Sbjct: 1499 --NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556



 Score =  101 bits (252), Expect = 2e-21
 Identities = 128/630 (20%), Positives = 281/630 (44%), Gaps = 63/630 (10%)

Query: 48   DGSSSREDLSSQLLRRNEQIRK-LEARLSDYAEQVRNL-QKIKEKLEIALEKHQDSSMRK 105
            D ++++++L S+  +    ++K LE     +  Q++ + QK  + +E   E+ + +   K
Sbjct: 1153 DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK 1212

Query: 106  --FQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNL 163
               ++  +T +  R ++A  + + L  K           E ++  + AQLQE++ +    
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDS--------EHKRKKVEAQLQELQVKFNEG 1264

Query: 164  FQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS 223
             + R E+ +     Q EL  +  +L + +    K+ ++  A   +L  TQE L   N+  
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324

Query: 224  SDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVT 283
              LS KL++++   ++  EQ +    +K   E +I  L  +  +++  ++  S+   +  
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED-SVGCLETA 1383

Query: 284  AETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARS 343
             E + K      LQ+ +  L +R E+ ++  +   +L K KT  +Q L+D    LL    
Sbjct: 1384 EEVKRK------LQKDLEGLSQRHEEKVAAYD---KLEKTKTRLQQELDD----LLVDLD 1430

Query: 344  SQAKAINTLETRVRELEQTLQASE-------EQLQQSKGIVAAQETQIQELAAANQESSH 396
             Q ++   LE + ++ +Q L   +       E+  +++     +ET+   LA A +E+  
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490

Query: 397  VQQQALALEQQFLERTQALEA-------QIVALERTRAADQTTAEQ---GMRQLEQENAA 446
             + +   L +QF    + L +        +  LE+++ A +   E+    + +LE E  A
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQA 1550

Query: 447  LKECRNEYERSLQ--NHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLT 504
             ++ +   E +LQ    QFE + L+    Q E     + + + E+  + E+ ++Q +   
Sbjct: 1551 TEDAKLRLEVNLQAMKAQFE-RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609

Query: 505  AIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAEL-EALRTL---KAEEA 560
            A   + E +L++        E  I    +  + A+ Q+ +LQA++ + +R L   +A   
Sbjct: 1610 AARKKLEMDLKD-------LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662

Query: 561  AVVAEQEDLLRLRGPLQAEALSVNE----SHVTSRAMQDPVFQL--PTAGRTPNGEVGAM 614
             ++A+ ++  +    ++AE + + E    +    R  Q    +L    A  +  G +   
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722

Query: 615  DLTQLQKEKQDLEQQLLEKNKTIKQMQQRM 644
            +  +L+     LE++L E+    + +  R+
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRL 1752



 Score =  100 bits (249), Expect = 5e-21
 Identities = 129/557 (23%), Positives = 246/557 (44%), Gaps = 74/557 (13%)

Query: 126  LALARKDQEWSEKMDQLEK--EKNILTA-QLQEMKNQSMNLFQRRDEMDELEGFQQQ--- 179
            L ++R+++E   K ++L K  EK +    +L EM+     L   + ++ E    + +   
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897

Query: 180  ELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYST 239
            E  +++  L  K++ L ++  +LEAR  E    +E   +       + Q ++EL+     
Sbjct: 898  EAEELRARLTAKKQELEEICHDLEARVEE---EEERCQHLQAEKKKMQQNIQELEEQLEE 954

Query: 240  LEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEK 299
             E  R  +   K   E+K+  LE+++  L+    +L+ + + +     E    +T  +EK
Sbjct: 955  EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 300  VASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVREL 359
              SL K   ++ +    ++E L+ +    Q LE TR++L    +  +  I  L+ ++ EL
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL 1074

Query: 360  EQTLQASEEQLQQSKGIV---AAQ-----------ETQIQELAAANQESSHVQQQALALE 405
            +  L   EE+LQ +   V   AAQ           E+QI EL    +     + +A   E
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA---E 1131

Query: 406  QQFLERTQALEAQIVALERTRAADQTTAEQGMR-QLEQENAALKECRNEYERSLQNHQFE 464
            +Q  +  + LEA    LE T   D T A+Q +R + EQE   LK+     E   + H+ +
Sbjct: 1132 KQKRDLGEELEALKTELEDT--LDSTAAQQELRSKREQEVNILKK---TLEEEAKTHEAQ 1186

Query: 465  LKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQK 524
            +++++++ S          QA+EE+ +Q E+ ++  ANL    ++ +Q L  +   L  +
Sbjct: 1187 IQEMRQKHS----------QAVEELAEQLEQTKRVKANL----EKAKQTLENERGELANE 1232

Query: 525  EQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVN 584
             + +LQ   G   +  +  +++A+L+ L+    E   V  E  D        +   L V 
Sbjct: 1233 VKVLLQ---GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD--------KVTKLQVE 1281

Query: 585  ESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNK-------TI 637
              +VT    Q                    D + L+ + QD ++ L E+N+        +
Sbjct: 1282 LDNVTGLLSQS----------DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331

Query: 638  KQMQQRMLELRKTLQKE 654
            KQ++      R+ L++E
Sbjct: 1332 KQVEDEKNSFREQLEEE 1348



 Score =  100 bits (248), Expect = 7e-21
 Identities = 122/631 (19%), Positives = 261/631 (41%), Gaps = 56/631 (8%)

Query: 48   DGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQ 107
            D    R+ + +QL     +  + E   ++ A++V  LQ   + +   L    DS   K  
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVT-GLLSQSDSKSSKLT 1300

Query: 108  EQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRR 167
            +     ++      E L     R+    S K+ Q+E EKN    QL+E +    NL ++ 
Sbjct: 1301 KDFSALESQLQDTQE-LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359

Query: 168  DEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLS 227
              +           +++  M  K E+S+G +E   E + +     Q++L   +Q   +  
Sbjct: 1360 ATLH----------AQVADMKKKMEDSVGCLETAEEVKRK----LQKDLEGLSQRHEEKV 1405

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
               ++L++  + L+++ D ++            LE+K+++   L+ +      K   E  
Sbjct: 1406 AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD 1465

Query: 288  EKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAK 347
              E      + K  SL + LE+ +  +  ++ L K+     ++L  ++  +  +     K
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525

Query: 348  AINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAA-NQESSHVQQQALALEQ 406
            +   LE +V E++  L+  E++LQ ++      E  +Q + A   ++     +Q+   ++
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1585

Query: 407  QFLERTQALEAQIVALERTRA---ADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQF 463
            Q + + + +EA++    + R+   A +   E  ++ LE    +  + R+E  + L+  Q 
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA 1645

Query: 464  ELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQ 523
            ++K    E              L++ R  REE   QA        E E+ L+     ++Q
Sbjct: 1646 QMKDCMRE--------------LDDTRASREEILAQAK-------ENEKKLKSMEAEMIQ 1684

Query: 524  KEQEILQLERGHNSALLQIHQLQAELE--------ALRTLKAEEAAVVAEQEDLLRLRGP 575
             ++E+   ER    A  +  +L  E+         AL   +  EA +   +E+L   +G 
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744

Query: 576  LQAEALSVNESHVT-SRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKN 634
             +     + ++++   +   D   +   A +  N         QL+++ ++L+ +L E  
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENAR------QQLERQNKELKVKLQEME 1798

Query: 635  KTIKQMQQRMLELRKTLQKELKIRPDNELFE 665
             T+K   +  +   +    +L+ + DNE  E
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQLDNETKE 1829



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 87/436 (19%), Positives = 176/436 (40%), Gaps = 52/436 (11%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETF 113
            EDL S      + + +LE       +QV  ++   E+LE  L+  +D+ +R         
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR--------L 1558

Query: 114  QANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQ-EMKNQSMNLFQRRD-EMD 171
            + N   M       L  +D++  EK  QL ++   + A+L+ E K +SM +  R+  EMD
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618

Query: 172  -----------------------ELEGFQQQELSKIKHMLLKKEESLGKM---EQELEAR 205
                                   +L+   +  + ++      +EE L +    E++L++ 
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678

Query: 206  TRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKE 265
              E+ + QEEL  + +      Q+ +EL    +    +    +  K   E++I  LE++ 
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738

Query: 266  QELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKT 325
            +E Q   + ++  L+K   +       I  +   +       ++N +  + ++   KE  
Sbjct: 1739 EEEQGNTELINDRLKKANLQ-------IDQINTDLNLERSHAQKNENARQQLERQNKELK 1791

Query: 326  LAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQ 385
            +  Q +E T       +S    +I  LE ++ +LE+ L    ++ Q +   V   E +++
Sbjct: 1792 VKLQEMEGT------VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845

Query: 386  ELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENA 445
            ++     +     +Q      +   R + L+ Q+   E    A +  A +   Q E E+A
Sbjct: 1846 DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLE--EAEEEAQRANASRRKLQRELEDA 1903

Query: 446  A-LKECRNEYERSLQN 460
                +  N    SL+N
Sbjct: 1904 TETADAMNREVSSLKN 1919


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  121 bits (304), Expect = 2e-27
 Identities = 156/708 (22%), Positives = 301/708 (42%), Gaps = 91/708 (12%)

Query: 7    KKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQ 66
            KK+ +E  V           R + +E ++ +  +  ++         ++L+    +    
Sbjct: 981  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKNKHESM 1035

Query: 67   IRKLEARLSDYAEQVRNLQKIKEKLE-IALEKHQDSSMRKFQEQNETFQANRAKMAEGLA 125
            I +LE RL    +  + L+K+K KLE  A + H+   +   Q Q    +   AK  E L 
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ--IADLQAQIAELKMQLAKKEEELQ 1093

Query: 126  LALARKDQEWSEKMDQLEKEKNIL--TAQLQE-------MKNQSMNLFQRRDEMDELEGF 176
             ALAR D E ++K + L+K + +    + LQE        +N++    Q+RD  +ELE  
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK--QKRDLGEELEAL 1151

Query: 177  QQQELSKIKHMLLKKEESLGKMEQEL---------EARTRELSRTQEELMNSNQMSSDLS 227
            +  EL         ++E   K EQE+         E R+ E ++ QE      Q   +L+
Sbjct: 1152 KT-ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE-AQVQEMRQKHAQAVEELT 1209

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
            ++LE+ +R  + L++ +  +         ++  L Q +QE++   ++L   +Q++ ++  
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269

Query: 288  EKEDVITHLQEKVASLEKRLEQ--------------------NLSGE-EHVQELLKEKTL 326
            + E     L +KV  L+  +E                     +LS + +  QELL+E+T 
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329

Query: 327  AEQN-------LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAA 379
             + N       LE+ R  L      + +A   LE  +  L   L  S+++LQ     V A
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389

Query: 380  QETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTR----------AAD 429
             E          +     Q++   L QQ+ E+  A +     LE+T+            D
Sbjct: 1390 LE----------EGKKRFQKEIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVD 1435

Query: 430  QTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEV 489
                 Q +  LE++     +   E +     +  E  + + E  ++E  ++++A+ALEE 
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495

Query: 490  RKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAEL 549
             + +EE ++    L A   E E  +  K +V     + + +LE+   +   Q+ +++ +L
Sbjct: 1496 LEAKEELERTNKMLKA---EMEDLVSSKDDV----GKNVHELEKSKRALETQMEEMKTQL 1548

Query: 550  EALR-TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            E L   L+A E A +  + ++  L+G  + +  + +E +   R                 
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELK 656
             +  A+     +K + DL+   L+ +  IK  ++ + +LRK LQ ++K
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK-LQAQMK 1655



 Score =  118 bits (295), Expect = 2e-26
 Identities = 162/750 (21%), Positives = 317/750 (42%), Gaps = 148/750 (19%)

Query: 50   SSSREDLSSQLLRRN----------EQIRKLEARLSDYAEQVRNLQKIKEKLE---IALE 96
            S  +EDL S+   RN          E++  L+  L D  +     Q+++ K E     L+
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180

Query: 97   KHQDSSMRKFQEQNETFQANRAKMAEGLALALAR---------KDQEWSEKMD------- 140
            K  D   R  + Q +  +   A+  E L   L +         K+++  EK +       
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240

Query: 141  --------QLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE 192
                    ++E +K  L AQ+QE++++  +  + R E+++     Q E+  +  ML + E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300

Query: 193  ESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKT 252
                K+ +++ + + +L  TQE L    +   ++S KL +L+   ++L++Q D  + +K 
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360

Query: 253  GAE---------------------SKITALEQKEQELQALIQQLSIDLQKVTAETQEKED 291
              E                     S + ALE+ ++  Q  I+ L+   ++  A   + E 
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 292  VITHLQEKVASL------EKRLEQNLSGEEHV--QELLKEKTLAEQNLEDTRQQLLAARS 343
                LQ+++  L      +++L  NL  ++    Q L +EK ++ +  ++  +    AR 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 344  SQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALA 403
             + KA++      R LE+ L+A EE  + +K + A  E  +       +    +++   A
Sbjct: 1481 KETKALSL----ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536

Query: 404  LEQQFLE---RTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQN 460
            LE Q  E   + + LE ++ A E  +   +   +    Q E++  A  E   E  R LQ 
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596

Query: 461  --HQFELKKLKEEWSQREIVSVAMA---------------------QALEEVRK---QRE 494
              H++E + L++E  QR + + A                       +A++++RK   Q +
Sbjct: 1597 QLHEYETE-LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 495  EFQQQAANLTAIIDE-------KEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQA 547
            +FQ++  +  A  DE        E+  +     L+Q ++++   ER    A L+  +L  
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715

Query: 548  EL-------EALRTLKAE-EAAVVAEQEDLLRLRGPL------------QAEALS----- 582
            EL        AL+  K   EA +   +E+L   +G +            QAE LS     
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775

Query: 583  ------VNES-----HVTSRAMQDPVFQLPTAGRTP-NGEVGAMDLTQLQKEKQDLEQQL 630
                   NES        ++ ++  + ++  A ++     + A++    Q E+Q +EQ+ 
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-VEQEA 1834

Query: 631  LEKN---KTIKQMQQRMLELRKTLQKELKI 657
             EK    K++KQ  +++ E+   ++ E K+
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKM 1864



 Score =  105 bits (263), Expect = 1e-22
 Identities = 144/645 (22%), Positives = 288/645 (44%), Gaps = 87/645 (13%)

Query: 60   LLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRK--FQEQNETFQANR 117
            LL+   Q  +++A+  +  +     QK + +L+   +KH   +  K   QEQ +      
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 118  AKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQ 177
            A+ AE + + LA K QE  E + ++E       A+L+E +++   L   R +M       
Sbjct: 904  AE-AEEMRVRLAAKKQELEEILHEME-------ARLEEEEDRGQQLQAERKKM------- 948

Query: 178  QQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELM----NSNQMSSD---LSQKL 230
             Q++  ++  L ++E +  K++ E      ++ + ++E++     +N++S +   L +++
Sbjct: 949  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008

Query: 231  EELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKE 290
             +L  + +  EE+  ++   K   ES I+ LE + ++ +   Q+L    +K+  +  +  
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 291  DVITHLQEKVASLEKRLEQNLSGEEHVQELLK--EKTLAEQN--------LEDTRQQLLA 340
            + I  LQ ++A L+ +L +    EE +Q  L   +  +A++N        LE     L  
Sbjct: 1069 EQIADLQAQIAELKMQLAKK---EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 341  ARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQ 400
               S+  A N  E + R+L + L+A + +L+ +    A Q    QEL A  ++   V ++
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ----QELRAKREQEVTVLKK 1181

Query: 401  AL---------ALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENA------ 445
            AL          +++   +  QA+E     LE+ + A +   ++  + LE+ENA      
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGEL 1240

Query: 446  -ALKECRNEYERSLQNHQFELKKLKEEWS----------------QREIVSVAMAQALEE 488
              L + + E E   +  + ++++L+ + S                Q E+ SV     L E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV--TGMLNE 1298

Query: 489  VRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAE 548
               +  +  +  A+L++ + + ++ L+E+T   L    ++ QLE   NS  LQ  QL  E
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS--LQ-DQLDEE 1355

Query: 549  LEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            +EA + L+   + +  +  D    +  LQ  A +V       +  Q  +  L     T  
Sbjct: 1356 MEAKQNLERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIENL-----TQQ 1407

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
             E  A    +L+K K  L+Q+L +    +   +Q +  L K  +K
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452



 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 139/660 (21%), Positives = 279/660 (42%), Gaps = 105/660 (15%)

Query: 4    KLKKKIAEETAVA-QRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLR 62
            KL+ ++   T +  +  G A ++ + V+  S++S   D+  +   + +  + ++S++L +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVA--SLSSQLQDT-QELLQEETRQKLNVSTKLRQ 1340

Query: 63   RNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAE 122
              E+   L+ +L +  E  +NL++    L I L   +   ++ F    E  +  + +  +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK-KKLQDFASTVEALEEGKKRFQK 1399

Query: 123  GLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELS 182
             +   L ++ +E +   D+LEK KN L  +L ++     N  Q    +++ +    Q L+
Sbjct: 1400 EIE-NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458

Query: 183  KIKHMLLKKEESLGKME---QELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYST 239
            + K++  K  +   + E   +E E +   L+R  EE + +           EEL+R    
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK----------EELERTNKM 1508

Query: 240  LEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEK 299
            L+ + + +++SK      +  LE+ ++ L+  ++++   L+++  E Q  ED    L+  
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568

Query: 300  VASLEKRLEQNLSG-----EEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLET 354
            + +L+ + E++L       EE  ++L ++    E  LED R+Q   A +++ K    L+ 
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 355  RVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHV-------QQQALALEQQ 407
               + +  ++  EE ++Q + + A  +   +EL  A      +       +++A +LE  
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688

Query: 408  FLERTQALEAQIVALERTR----------AADQTTAEQGMRQLEQENAALKECRNEYERS 457
             ++    L+  + A ER R          A +  ++  G   L+ E   L+    + E  
Sbjct: 1689 LMQ----LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 458  LQNHQFELKKLK----------EEWSQREIVSVAMAQALEEVRKQRE------------- 494
            L+  Q  ++ +           E+ S       + AQ  E  R+Q E             
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804

Query: 495  ------EFQQQAANLTAII----DEKEQNLREKT--------------EVLLQKEQEILQ 530
                  +F+   A L A I    ++ EQ  REK               E+LLQ E E   
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864

Query: 531  LERGHNSA---LLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESH 587
             E+    A     ++ QL+ +LE     +AEE     E + +   R  LQ E     ES+
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLE-----EAEE-----ESQRINANRRKLQRELDEATESN 1914



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 115/539 (21%), Positives = 236/539 (43%), Gaps = 82/539 (15%)

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMA 121
            R  +++  L   L +  + V NL+K + K +  L + ++ S  K+ ++ +  +A  A+  
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYADERDRAEAE-AREK 1481

Query: 122  EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQEL 181
            E  AL+LAR  +E  E  ++LE+   +L A+++++ +   ++ +   E+++ +   + ++
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 182  SKIKHMLLKKEESL------------------GKMEQELEART-----------RELSRT 212
             ++K  L + E+ L                  G+ E++L+AR            R+L   
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 213  QEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALI 272
            + EL +  +  +  +   ++L+     LE Q D  I  +  A  ++  L+ + ++ Q  +
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 273  QQLSIDLQKVTAETQEKEDV-------ITHLQEKVASLEK-RLEQNLSGEEHVQELLKEK 324
            +       ++ A  +E E         +  LQE +A+ E+ R + +L  EE  +EL    
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-- 1719

Query: 325  TLAEQNLEDTRQQLLAARSSQAKA--------INTLETRVRELEQTLQASEEQLQQSKGI 376
            +L+ +N     ++ L AR +Q +         +  +  RVR+  Q  +    +L   +  
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779

Query: 377  VAAQETQIQELAAANQE-SSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQ 435
                E+  Q+L   N+E  S + +   A++ +F     ALEA+I  LE          EQ
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE----------EQ 1829

Query: 436  GMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREE 495
              ++  ++ AA K  + +            KKLKE   Q           +E+ RK  E+
Sbjct: 1830 VEQEAREKQAATKSLKQKD-----------KKLKEILLQ-----------VEDERKMAEQ 1867

Query: 496  FQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRT 554
            +++QA    A + + ++ L E  E   +      +L+R  + A      +  E+ AL++
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 111/534 (20%), Positives = 229/534 (42%), Gaps = 62/534 (11%)

Query: 182  SKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLE 241
            +K+K +L      + + E+E++A+  EL +T+E    +     +L QK  +L    + L+
Sbjct: 839  TKVKPLL-----QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ 893

Query: 242  EQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVA 301
            EQ          AE     L  K+QEL+ ++ ++   L++     Q+ +     + +++ 
Sbjct: 894  EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953

Query: 302  SLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA---ARSSQAKAINTLETRVRE 358
             LE++LE+    E   Q+L  EK  AE  ++    ++L      +  +K    LE R+ +
Sbjct: 954  DLEEQLEEE---EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010

Query: 359  LEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQ-------FLER 411
            L   L   EE+ +    +    E+ I EL    ++    +Q+   L+++       F E+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 412  TQALEAQIVALERTRAADQTTAEQGMRQLE----QENAALKECRNEYERSLQNHQFELKK 467
               L+AQI  L+   A  +   +  + +L+    Q+N ALK+ R E E  + + Q +L  
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDS 1129

Query: 468  LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQK--- 524
             +   ++ E     + + LE ++ + E+     A    +  ++EQ +    + L ++   
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189

Query: 525  -EQEILQLERGHNSALLQI-HQLQAELEALRTLKAEEAAVVAEQEDL---LRLRGPLQAE 579
             E ++ ++ + H  A+ ++  QL+    A   L   +  +  E  DL   LR+ G  + E
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 580  A------LSVNESHVTSRA---------MQDPVFQLPTAGRTPNGEVG---------AMD 615
                   L      + S+          + D V +L     +  G +          A D
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 616  LTQLQKEKQDLEQQLLEKNK-------TIKQMQQRMLELRKTLQKELKIRPDNE 662
            +  L  + QD ++ L E+ +        ++Q+++    L+  L +E++ + + E
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 43/181 (23%), Positives = 76/181 (41%), Gaps = 50/181 (27%)

Query: 486 LEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQL 545
           L +V +Q EE Q            KE  L++  E   + E E+ +LE+ H+    + + L
Sbjct: 844 LLQVTRQEEEMQA-----------KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892

Query: 546 QAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGR 605
           Q +L+A       E  + AE E++ R+R   + + L      + +R              
Sbjct: 893 QEQLQA-------ETELYAEAEEM-RVRLAAKKQELEEILHEMEARL------------- 931

Query: 606 TPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFE 665
                          +E++D  QQL  + K   +M Q+ML+L + L++E   R   +L +
Sbjct: 932 ---------------EEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEAARQKLQLEK 973

Query: 666 V 666
           V
Sbjct: 974 V 974


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  121 bits (304), Expect = 2e-27
 Identities = 156/708 (22%), Positives = 301/708 (42%), Gaps = 91/708 (12%)

Query: 7    KKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQ 66
            KK+ +E  V           R + +E ++ +  +  ++         ++L+    +    
Sbjct: 988  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKNKHESM 1042

Query: 67   IRKLEARLSDYAEQVRNLQKIKEKLE-IALEKHQDSSMRKFQEQNETFQANRAKMAEGLA 125
            I +LE RL    +  + L+K+K KLE  A + H+   +   Q Q    +   AK  E L 
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ--IADLQAQIAELKMQLAKKEEELQ 1100

Query: 126  LALARKDQEWSEKMDQLEKEKNIL--TAQLQE-------MKNQSMNLFQRRDEMDELEGF 176
             ALAR D E ++K + L+K + +    + LQE        +N++    Q+RD  +ELE  
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK--QKRDLGEELEAL 1158

Query: 177  QQQELSKIKHMLLKKEESLGKMEQEL---------EARTRELSRTQEELMNSNQMSSDLS 227
            +  EL         ++E   K EQE+         E R+ E ++ QE      Q   +L+
Sbjct: 1159 KT-ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE-AQVQEMRQKHAQAVEELT 1216

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
            ++LE+ +R  + L++ +  +         ++  L Q +QE++   ++L   +Q++ ++  
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276

Query: 288  EKEDVITHLQEKVASLEKRLEQ--------------------NLSGE-EHVQELLKEKTL 326
            + E     L +KV  L+  +E                     +LS + +  QELL+E+T 
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336

Query: 327  AEQN-------LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAA 379
             + N       LE+ R  L      + +A   LE  +  L   L  S+++LQ     V A
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396

Query: 380  QETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTR----------AAD 429
             E          +     Q++   L QQ+ E+  A +     LE+T+            D
Sbjct: 1397 LE----------EGKKRFQKEIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVD 1442

Query: 430  QTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEV 489
                 Q +  LE++     +   E +     +  E  + + E  ++E  ++++A+ALEE 
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502

Query: 490  RKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAEL 549
             + +EE ++    L A   E E  +  K +V     + + +LE+   +   Q+ +++ +L
Sbjct: 1503 LEAKEELERTNKMLKA---EMEDLVSSKDDV----GKNVHELEKSKRALETQMEEMKTQL 1555

Query: 550  EALR-TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            E L   L+A E A +  + ++  L+G  + +  + +E +   R                 
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELK 656
             +  A+     +K + DL+   L+ +  IK  ++ + +LRK LQ ++K
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK-LQAQMK 1662



 Score =  118 bits (295), Expect = 2e-26
 Identities = 162/750 (21%), Positives = 317/750 (42%), Gaps = 148/750 (19%)

Query: 50   SSSREDLSSQLLRRN----------EQIRKLEARLSDYAEQVRNLQKIKEKLE---IALE 96
            S  +EDL S+   RN          E++  L+  L D  +     Q+++ K E     L+
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187

Query: 97   KHQDSSMRKFQEQNETFQANRAKMAEGLALALAR---------KDQEWSEKMD------- 140
            K  D   R  + Q +  +   A+  E L   L +         K+++  EK +       
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247

Query: 141  --------QLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE 192
                    ++E +K  L AQ+QE++++  +  + R E+++     Q E+  +  ML + E
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307

Query: 193  ESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKT 252
                K+ +++ + + +L  TQE L    +   ++S KL +L+   ++L++Q D  + +K 
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367

Query: 253  GAE---------------------SKITALEQKEQELQALIQQLSIDLQKVTAETQEKED 291
              E                     S + ALE+ ++  Q  I+ L+   ++  A   + E 
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 292  VITHLQEKVASL------EKRLEQNLSGEEHV--QELLKEKTLAEQNLEDTRQQLLAARS 343
                LQ+++  L      +++L  NL  ++    Q L +EK ++ +  ++  +    AR 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 344  SQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALA 403
             + KA++      R LE+ L+A EE  + +K + A  E  +       +    +++   A
Sbjct: 1488 KETKALSL----ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543

Query: 404  LEQQFLE---RTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQN 460
            LE Q  E   + + LE ++ A E  +   +   +    Q E++  A  E   E  R LQ 
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603

Query: 461  --HQFELKKLKEEWSQREIVSVAMA---------------------QALEEVRK---QRE 494
              H++E + L++E  QR + + A                       +A++++RK   Q +
Sbjct: 1604 QLHEYETE-LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 495  EFQQQAANLTAIIDE-------KEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQA 547
            +FQ++  +  A  DE        E+  +     L+Q ++++   ER    A L+  +L  
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722

Query: 548  EL-------EALRTLKAE-EAAVVAEQEDLLRLRGPL------------QAEALS----- 582
            EL        AL+  K   EA +   +E+L   +G +            QAE LS     
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782

Query: 583  ------VNES-----HVTSRAMQDPVFQLPTAGRTP-NGEVGAMDLTQLQKEKQDLEQQL 630
                   NES        ++ ++  + ++  A ++     + A++    Q E+Q +EQ+ 
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-VEQEA 1841

Query: 631  LEKN---KTIKQMQQRMLELRKTLQKELKI 657
             EK    K++KQ  +++ E+   ++ E K+
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKM 1871



 Score =  105 bits (263), Expect = 1e-22
 Identities = 144/645 (22%), Positives = 288/645 (44%), Gaps = 87/645 (13%)

Query: 60   LLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRK--FQEQNETFQANR 117
            LL+   Q  +++A+  +  +     QK + +L+   +KH   +  K   QEQ +      
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 118  AKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQ 177
            A+ AE + + LA K QE  E + ++E       A+L+E +++   L   R +M       
Sbjct: 911  AE-AEEMRVRLAAKKQELEEILHEME-------ARLEEEEDRGQQLQAERKKM------- 955

Query: 178  QQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELM----NSNQMSSD---LSQKL 230
             Q++  ++  L ++E +  K++ E      ++ + ++E++     +N++S +   L +++
Sbjct: 956  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015

Query: 231  EELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKE 290
             +L  + +  EE+  ++   K   ES I+ LE + ++ +   Q+L    +K+  +  +  
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 291  DVITHLQEKVASLEKRLEQNLSGEEHVQELLK--EKTLAEQN--------LEDTRQQLLA 340
            + I  LQ ++A L+ +L +    EE +Q  L   +  +A++N        LE     L  
Sbjct: 1076 EQIADLQAQIAELKMQLAKK---EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 341  ARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQ 400
               S+  A N  E + R+L + L+A + +L+ +    A Q    QEL A  ++   V ++
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ----QELRAKREQEVTVLKK 1188

Query: 401  AL---------ALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENA------ 445
            AL          +++   +  QA+E     LE+ + A +   ++  + LE+ENA      
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGEL 1247

Query: 446  -ALKECRNEYERSLQNHQFELKKLKEEWS----------------QREIVSVAMAQALEE 488
              L + + E E   +  + ++++L+ + S                Q E+ SV     L E
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV--TGMLNE 1305

Query: 489  VRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAE 548
               +  +  +  A+L++ + + ++ L+E+T   L    ++ QLE   NS  LQ  QL  E
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS--LQ-DQLDEE 1362

Query: 549  LEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            +EA + L+   + +  +  D    +  LQ  A +V       +  Q  +  L     T  
Sbjct: 1363 MEAKQNLERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIENL-----TQQ 1414

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
             E  A    +L+K K  L+Q+L +    +   +Q +  L K  +K
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459



 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 139/660 (21%), Positives = 279/660 (42%), Gaps = 105/660 (15%)

Query: 4    KLKKKIAEETAVA-QRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLR 62
            KL+ ++   T +  +  G A ++ + V+  S++S   D+  +   + +  + ++S++L +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVA--SLSSQLQDT-QELLQEETRQKLNVSTKLRQ 1347

Query: 63   RNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAE 122
              E+   L+ +L +  E  +NL++    L I L   +   ++ F    E  +  + +  +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK-KKLQDFASTVEALEEGKKRFQK 1406

Query: 123  GLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELS 182
             +   L ++ +E +   D+LEK KN L  +L ++     N  Q    +++ +    Q L+
Sbjct: 1407 EIE-NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465

Query: 183  KIKHMLLKKEESLGKME---QELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYST 239
            + K++  K  +   + E   +E E +   L+R  EE + +           EEL+R    
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK----------EELERTNKM 1515

Query: 240  LEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEK 299
            L+ + + +++SK      +  LE+ ++ L+  ++++   L+++  E Q  ED    L+  
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575

Query: 300  VASLEKRLEQNLSG-----EEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLET 354
            + +L+ + E++L       EE  ++L ++    E  LED R+Q   A +++ K    L+ 
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 355  RVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHV-------QQQALALEQQ 407
               + +  ++  EE ++Q + + A  +   +EL  A      +       +++A +LE  
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695

Query: 408  FLERTQALEAQIVALERTR----------AADQTTAEQGMRQLEQENAALKECRNEYERS 457
             ++    L+  + A ER R          A +  ++  G   L+ E   L+    + E  
Sbjct: 1696 LMQ----LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 458  LQNHQFELKKLK----------EEWSQREIVSVAMAQALEEVRKQRE------------- 494
            L+  Q  ++ +           E+ S       + AQ  E  R+Q E             
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811

Query: 495  ------EFQQQAANLTAII----DEKEQNLREKT--------------EVLLQKEQEILQ 530
                  +F+   A L A I    ++ EQ  REK               E+LLQ E E   
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871

Query: 531  LERGHNSA---LLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESH 587
             E+    A     ++ QL+ +LE     +AEE     E + +   R  LQ E     ES+
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLE-----EAEE-----ESQRINANRRKLQRELDEATESN 1921



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 115/539 (21%), Positives = 236/539 (43%), Gaps = 82/539 (15%)

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMA 121
            R  +++  L   L +  + V NL+K + K +  L + ++ S  K+ ++ +  +A  A+  
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYADERDRAEAE-AREK 1488

Query: 122  EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQEL 181
            E  AL+LAR  +E  E  ++LE+   +L A+++++ +   ++ +   E+++ +   + ++
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 182  SKIKHMLLKKEESL------------------GKMEQELEART-----------RELSRT 212
             ++K  L + E+ L                  G+ E++L+AR            R+L   
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 213  QEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALI 272
            + EL +  +  +  +   ++L+     LE Q D  I  +  A  ++  L+ + ++ Q  +
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 273  QQLSIDLQKVTAETQEKEDV-------ITHLQEKVASLEK-RLEQNLSGEEHVQELLKEK 324
            +       ++ A  +E E         +  LQE +A+ E+ R + +L  EE  +EL    
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-- 1726

Query: 325  TLAEQNLEDTRQQLLAARSSQAKA--------INTLETRVRELEQTLQASEEQLQQSKGI 376
            +L+ +N     ++ L AR +Q +         +  +  RVR+  Q  +    +L   +  
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786

Query: 377  VAAQETQIQELAAANQE-SSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQ 435
                E+  Q+L   N+E  S + +   A++ +F     ALEA+I  LE          EQ
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE----------EQ 1836

Query: 436  GMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREE 495
              ++  ++ AA K  + +            KKLKE   Q           +E+ RK  E+
Sbjct: 1837 VEQEAREKQAATKSLKQKD-----------KKLKEILLQ-----------VEDERKMAEQ 1874

Query: 496  FQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRT 554
            +++QA    A + + ++ L E  E   +      +L+R  + A      +  E+ AL++
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 111/534 (20%), Positives = 229/534 (42%), Gaps = 62/534 (11%)

Query: 182  SKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLE 241
            +K+K +L      + + E+E++A+  EL +T+E    +     +L QK  +L    + L+
Sbjct: 846  TKVKPLL-----QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ 900

Query: 242  EQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVA 301
            EQ          AE     L  K+QEL+ ++ ++   L++     Q+ +     + +++ 
Sbjct: 901  EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960

Query: 302  SLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA---ARSSQAKAINTLETRVRE 358
             LE++LE+    E   Q+L  EK  AE  ++    ++L      +  +K    LE R+ +
Sbjct: 961  DLEEQLEEE---EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017

Query: 359  LEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQ-------FLER 411
            L   L   EE+ +    +    E+ I EL    ++    +Q+   L+++       F E+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 412  TQALEAQIVALERTRAADQTTAEQGMRQLE----QENAALKECRNEYERSLQNHQFELKK 467
               L+AQI  L+   A  +   +  + +L+    Q+N ALK+ R E E  + + Q +L  
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDS 1136

Query: 468  LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQK--- 524
             +   ++ E     + + LE ++ + E+     A    +  ++EQ +    + L ++   
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196

Query: 525  -EQEILQLERGHNSALLQI-HQLQAELEALRTLKAEEAAVVAEQEDL---LRLRGPLQAE 579
             E ++ ++ + H  A+ ++  QL+    A   L   +  +  E  DL   LR+ G  + E
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 580  A------LSVNESHVTSRA---------MQDPVFQLPTAGRTPNGEVG---------AMD 615
                   L      + S+          + D V +L     +  G +          A D
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 616  LTQLQKEKQDLEQQLLEKNK-------TIKQMQQRMLELRKTLQKELKIRPDNE 662
            +  L  + QD ++ L E+ +        ++Q+++    L+  L +E++ + + E
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 43/181 (23%), Positives = 76/181 (41%), Gaps = 50/181 (27%)

Query: 486 LEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQL 545
           L +V +Q EE Q            KE  L++  E   + E E+ +LE+ H+    + + L
Sbjct: 851 LLQVTRQEEEMQA-----------KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899

Query: 546 QAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGR 605
           Q +L+A       E  + AE E++ R+R   + + L      + +R              
Sbjct: 900 QEQLQA-------ETELYAEAEEM-RVRLAAKKQELEEILHEMEARL------------- 938

Query: 606 TPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFE 665
                          +E++D  QQL  + K   +M Q+ML+L + L++E   R   +L +
Sbjct: 939 ---------------EEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEAARQKLQLEK 980

Query: 666 V 666
           V
Sbjct: 981 V 981


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  121 bits (304), Expect = 2e-27
 Identities = 156/708 (22%), Positives = 301/708 (42%), Gaps = 91/708 (12%)

Query: 7    KKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQ 66
            KK+ +E  V           R + +E ++ +  +  ++         ++L+    +    
Sbjct: 988  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKNKHESM 1042

Query: 67   IRKLEARLSDYAEQVRNLQKIKEKLE-IALEKHQDSSMRKFQEQNETFQANRAKMAEGLA 125
            I +LE RL    +  + L+K+K KLE  A + H+   +   Q Q    +   AK  E L 
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ--IADLQAQIAELKMQLAKKEEELQ 1100

Query: 126  LALARKDQEWSEKMDQLEKEKNIL--TAQLQE-------MKNQSMNLFQRRDEMDELEGF 176
             ALAR D E ++K + L+K + +    + LQE        +N++    Q+RD  +ELE  
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK--QKRDLGEELEAL 1158

Query: 177  QQQELSKIKHMLLKKEESLGKMEQEL---------EARTRELSRTQEELMNSNQMSSDLS 227
            +  EL         ++E   K EQE+         E R+ E ++ QE      Q   +L+
Sbjct: 1159 KT-ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE-AQVQEMRQKHAQAVEELT 1216

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
            ++LE+ +R  + L++ +  +         ++  L Q +QE++   ++L   +Q++ ++  
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276

Query: 288  EKEDVITHLQEKVASLEKRLEQ--------------------NLSGE-EHVQELLKEKTL 326
            + E     L +KV  L+  +E                     +LS + +  QELL+E+T 
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336

Query: 327  AEQN-------LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAA 379
             + N       LE+ R  L      + +A   LE  +  L   L  S+++LQ     V A
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396

Query: 380  QETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTR----------AAD 429
             E          +     Q++   L QQ+ E+  A +     LE+T+            D
Sbjct: 1397 LE----------EGKKRFQKEIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVD 1442

Query: 430  QTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEV 489
                 Q +  LE++     +   E +     +  E  + + E  ++E  ++++A+ALEE 
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502

Query: 490  RKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAEL 549
             + +EE ++    L A   E E  +  K +V     + + +LE+   +   Q+ +++ +L
Sbjct: 1503 LEAKEELERTNKMLKA---EMEDLVSSKDDV----GKNVHELEKSKRALETQMEEMKTQL 1555

Query: 550  EALR-TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            E L   L+A E A +  + ++  L+G  + +  + +E +   R                 
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELK 656
             +  A+     +K + DL+   L+ +  IK  ++ + +LRK LQ ++K
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK-LQAQMK 1662



 Score =  118 bits (295), Expect = 2e-26
 Identities = 162/750 (21%), Positives = 317/750 (42%), Gaps = 148/750 (19%)

Query: 50   SSSREDLSSQLLRRN----------EQIRKLEARLSDYAEQVRNLQKIKEKLE---IALE 96
            S  +EDL S+   RN          E++  L+  L D  +     Q+++ K E     L+
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187

Query: 97   KHQDSSMRKFQEQNETFQANRAKMAEGLALALAR---------KDQEWSEKMD------- 140
            K  D   R  + Q +  +   A+  E L   L +         K+++  EK +       
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247

Query: 141  --------QLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE 192
                    ++E +K  L AQ+QE++++  +  + R E+++     Q E+  +  ML + E
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307

Query: 193  ESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKT 252
                K+ +++ + + +L  TQE L    +   ++S KL +L+   ++L++Q D  + +K 
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367

Query: 253  GAE---------------------SKITALEQKEQELQALIQQLSIDLQKVTAETQEKED 291
              E                     S + ALE+ ++  Q  I+ L+   ++  A   + E 
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 292  VITHLQEKVASL------EKRLEQNLSGEEHV--QELLKEKTLAEQNLEDTRQQLLAARS 343
                LQ+++  L      +++L  NL  ++    Q L +EK ++ +  ++  +    AR 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 344  SQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALA 403
             + KA++      R LE+ L+A EE  + +K + A  E  +       +    +++   A
Sbjct: 1488 KETKALSL----ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543

Query: 404  LEQQFLE---RTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQN 460
            LE Q  E   + + LE ++ A E  +   +   +    Q E++  A  E   E  R LQ 
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603

Query: 461  --HQFELKKLKEEWSQREIVSVAMA---------------------QALEEVRK---QRE 494
              H++E + L++E  QR + + A                       +A++++RK   Q +
Sbjct: 1604 QLHEYETE-LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 495  EFQQQAANLTAIIDE-------KEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQA 547
            +FQ++  +  A  DE        E+  +     L+Q ++++   ER    A L+  +L  
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722

Query: 548  EL-------EALRTLKAE-EAAVVAEQEDLLRLRGPL------------QAEALS----- 582
            EL        AL+  K   EA +   +E+L   +G +            QAE LS     
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782

Query: 583  ------VNES-----HVTSRAMQDPVFQLPTAGRTP-NGEVGAMDLTQLQKEKQDLEQQL 630
                   NES        ++ ++  + ++  A ++     + A++    Q E+Q +EQ+ 
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-VEQEA 1841

Query: 631  LEKN---KTIKQMQQRMLELRKTLQKELKI 657
             EK    K++KQ  +++ E+   ++ E K+
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKM 1871



 Score =  105 bits (263), Expect = 1e-22
 Identities = 144/645 (22%), Positives = 288/645 (44%), Gaps = 87/645 (13%)

Query: 60   LLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRK--FQEQNETFQANR 117
            LL+   Q  +++A+  +  +     QK + +L+   +KH   +  K   QEQ +      
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 118  AKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQ 177
            A+ AE + + LA K QE  E + ++E       A+L+E +++   L   R +M       
Sbjct: 911  AE-AEEMRVRLAAKKQELEEILHEME-------ARLEEEEDRGQQLQAERKKM------- 955

Query: 178  QQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELM----NSNQMSSD---LSQKL 230
             Q++  ++  L ++E +  K++ E      ++ + ++E++     +N++S +   L +++
Sbjct: 956  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015

Query: 231  EELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKE 290
             +L  + +  EE+  ++   K   ES I+ LE + ++ +   Q+L    +K+  +  +  
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 291  DVITHLQEKVASLEKRLEQNLSGEEHVQELLK--EKTLAEQN--------LEDTRQQLLA 340
            + I  LQ ++A L+ +L +    EE +Q  L   +  +A++N        LE     L  
Sbjct: 1076 EQIADLQAQIAELKMQLAKK---EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 341  ARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQ 400
               S+  A N  E + R+L + L+A + +L+ +    A Q    QEL A  ++   V ++
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ----QELRAKREQEVTVLKK 1188

Query: 401  AL---------ALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENA------ 445
            AL          +++   +  QA+E     LE+ + A +   ++  + LE+ENA      
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGEL 1247

Query: 446  -ALKECRNEYERSLQNHQFELKKLKEEWS----------------QREIVSVAMAQALEE 488
              L + + E E   +  + ++++L+ + S                Q E+ SV     L E
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV--TGMLNE 1305

Query: 489  VRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAE 548
               +  +  +  A+L++ + + ++ L+E+T   L    ++ QLE   NS  LQ  QL  E
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS--LQ-DQLDEE 1362

Query: 549  LEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            +EA + L+   + +  +  D    +  LQ  A +V       +  Q  +  L     T  
Sbjct: 1363 MEAKQNLERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIENL-----TQQ 1414

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
             E  A    +L+K K  L+Q+L +    +   +Q +  L K  +K
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459



 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 139/660 (21%), Positives = 279/660 (42%), Gaps = 105/660 (15%)

Query: 4    KLKKKIAEETAVA-QRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLR 62
            KL+ ++   T +  +  G A ++ + V+  S++S   D+  +   + +  + ++S++L +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVA--SLSSQLQDT-QELLQEETRQKLNVSTKLRQ 1347

Query: 63   RNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAE 122
              E+   L+ +L +  E  +NL++    L I L   +   ++ F    E  +  + +  +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK-KKLQDFASTVEALEEGKKRFQK 1406

Query: 123  GLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELS 182
             +   L ++ +E +   D+LEK KN L  +L ++     N  Q    +++ +    Q L+
Sbjct: 1407 EIE-NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465

Query: 183  KIKHMLLKKEESLGKME---QELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYST 239
            + K++  K  +   + E   +E E +   L+R  EE + +           EEL+R    
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK----------EELERTNKM 1515

Query: 240  LEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEK 299
            L+ + + +++SK      +  LE+ ++ L+  ++++   L+++  E Q  ED    L+  
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575

Query: 300  VASLEKRLEQNLSG-----EEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLET 354
            + +L+ + E++L       EE  ++L ++    E  LED R+Q   A +++ K    L+ 
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 355  RVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHV-------QQQALALEQQ 407
               + +  ++  EE ++Q + + A  +   +EL  A      +       +++A +LE  
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695

Query: 408  FLERTQALEAQIVALERTR----------AADQTTAEQGMRQLEQENAALKECRNEYERS 457
             ++    L+  + A ER R          A +  ++  G   L+ E   L+    + E  
Sbjct: 1696 LMQ----LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 458  LQNHQFELKKLK----------EEWSQREIVSVAMAQALEEVRKQRE------------- 494
            L+  Q  ++ +           E+ S       + AQ  E  R+Q E             
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811

Query: 495  ------EFQQQAANLTAII----DEKEQNLREKT--------------EVLLQKEQEILQ 530
                  +F+   A L A I    ++ EQ  REK               E+LLQ E E   
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871

Query: 531  LERGHNSA---LLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESH 587
             E+    A     ++ QL+ +LE     +AEE     E + +   R  LQ E     ES+
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLE-----EAEE-----ESQRINANRRKLQRELDEATESN 1921



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 115/539 (21%), Positives = 236/539 (43%), Gaps = 82/539 (15%)

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMA 121
            R  +++  L   L +  + V NL+K + K +  L + ++ S  K+ ++ +  +A  A+  
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYADERDRAEAE-AREK 1488

Query: 122  EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQEL 181
            E  AL+LAR  +E  E  ++LE+   +L A+++++ +   ++ +   E+++ +   + ++
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 182  SKIKHMLLKKEESL------------------GKMEQELEART-----------RELSRT 212
             ++K  L + E+ L                  G+ E++L+AR            R+L   
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 213  QEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALI 272
            + EL +  +  +  +   ++L+     LE Q D  I  +  A  ++  L+ + ++ Q  +
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 273  QQLSIDLQKVTAETQEKEDV-------ITHLQEKVASLEK-RLEQNLSGEEHVQELLKEK 324
            +       ++ A  +E E         +  LQE +A+ E+ R + +L  EE  +EL    
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-- 1726

Query: 325  TLAEQNLEDTRQQLLAARSSQAKA--------INTLETRVRELEQTLQASEEQLQQSKGI 376
            +L+ +N     ++ L AR +Q +         +  +  RVR+  Q  +    +L   +  
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786

Query: 377  VAAQETQIQELAAANQE-SSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQ 435
                E+  Q+L   N+E  S + +   A++ +F     ALEA+I  LE          EQ
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE----------EQ 1836

Query: 436  GMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREE 495
              ++  ++ AA K  + +            KKLKE   Q           +E+ RK  E+
Sbjct: 1837 VEQEAREKQAATKSLKQKD-----------KKLKEILLQ-----------VEDERKMAEQ 1874

Query: 496  FQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRT 554
            +++QA    A + + ++ L E  E   +      +L+R  + A      +  E+ AL++
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 111/534 (20%), Positives = 229/534 (42%), Gaps = 62/534 (11%)

Query: 182  SKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLE 241
            +K+K +L      + + E+E++A+  EL +T+E    +     +L QK  +L    + L+
Sbjct: 846  TKVKPLL-----QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ 900

Query: 242  EQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVA 301
            EQ          AE     L  K+QEL+ ++ ++   L++     Q+ +     + +++ 
Sbjct: 901  EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960

Query: 302  SLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA---ARSSQAKAINTLETRVRE 358
             LE++LE+    E   Q+L  EK  AE  ++    ++L      +  +K    LE R+ +
Sbjct: 961  DLEEQLEEE---EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017

Query: 359  LEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQ-------FLER 411
            L   L   EE+ +    +    E+ I EL    ++    +Q+   L+++       F E+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 412  TQALEAQIVALERTRAADQTTAEQGMRQLE----QENAALKECRNEYERSLQNHQFELKK 467
               L+AQI  L+   A  +   +  + +L+    Q+N ALK+ R E E  + + Q +L  
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDS 1136

Query: 468  LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQK--- 524
             +   ++ E     + + LE ++ + E+     A    +  ++EQ +    + L ++   
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196

Query: 525  -EQEILQLERGHNSALLQI-HQLQAELEALRTLKAEEAAVVAEQEDL---LRLRGPLQAE 579
             E ++ ++ + H  A+ ++  QL+    A   L   +  +  E  DL   LR+ G  + E
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 580  A------LSVNESHVTSRA---------MQDPVFQLPTAGRTPNGEVG---------AMD 615
                   L      + S+          + D V +L     +  G +          A D
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 616  LTQLQKEKQDLEQQLLEKNK-------TIKQMQQRMLELRKTLQKELKIRPDNE 662
            +  L  + QD ++ L E+ +        ++Q+++    L+  L +E++ + + E
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 43/181 (23%), Positives = 76/181 (41%), Gaps = 50/181 (27%)

Query: 486 LEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQL 545
           L +V +Q EE Q            KE  L++  E   + E E+ +LE+ H+    + + L
Sbjct: 851 LLQVTRQEEEMQA-----------KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899

Query: 546 QAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGR 605
           Q +L+A       E  + AE E++ R+R   + + L      + +R              
Sbjct: 900 QEQLQA-------ETELYAEAEEM-RVRLAAKKQELEEILHEMEARL------------- 938

Query: 606 TPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFE 665
                          +E++D  QQL  + K   +M Q+ML+L + L++E   R   +L +
Sbjct: 939 ---------------EEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEAARQKLQLEK 980

Query: 666 V 666
           V
Sbjct: 981 V 981


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  121 bits (304), Expect = 2e-27
 Identities = 156/708 (22%), Positives = 301/708 (42%), Gaps = 91/708 (12%)

Query: 7    KKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQ 66
            KK+ +E  V           R + +E ++ +  +  ++         ++L+    +    
Sbjct: 981  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKNKHESM 1035

Query: 67   IRKLEARLSDYAEQVRNLQKIKEKLE-IALEKHQDSSMRKFQEQNETFQANRAKMAEGLA 125
            I +LE RL    +  + L+K+K KLE  A + H+   +   Q Q    +   AK  E L 
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ--IADLQAQIAELKMQLAKKEEELQ 1093

Query: 126  LALARKDQEWSEKMDQLEKEKNIL--TAQLQE-------MKNQSMNLFQRRDEMDELEGF 176
             ALAR D E ++K + L+K + +    + LQE        +N++    Q+RD  +ELE  
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK--QKRDLGEELEAL 1151

Query: 177  QQQELSKIKHMLLKKEESLGKMEQEL---------EARTRELSRTQEELMNSNQMSSDLS 227
            +  EL         ++E   K EQE+         E R+ E ++ QE      Q   +L+
Sbjct: 1152 KT-ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE-AQVQEMRQKHAQAVEELT 1209

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
            ++LE+ +R  + L++ +  +         ++  L Q +QE++   ++L   +Q++ ++  
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269

Query: 288  EKEDVITHLQEKVASLEKRLEQ--------------------NLSGE-EHVQELLKEKTL 326
            + E     L +KV  L+  +E                     +LS + +  QELL+E+T 
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329

Query: 327  AEQN-------LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAA 379
             + N       LE+ R  L      + +A   LE  +  L   L  S+++LQ     V A
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389

Query: 380  QETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTR----------AAD 429
             E          +     Q++   L QQ+ E+  A +     LE+T+            D
Sbjct: 1390 LE----------EGKKRFQKEIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVD 1435

Query: 430  QTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEV 489
                 Q +  LE++     +   E +     +  E  + + E  ++E  ++++A+ALEE 
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495

Query: 490  RKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAEL 549
             + +EE ++    L A   E E  +  K +V     + + +LE+   +   Q+ +++ +L
Sbjct: 1496 LEAKEELERTNKMLKA---EMEDLVSSKDDV----GKNVHELEKSKRALETQMEEMKTQL 1548

Query: 550  EALR-TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            E L   L+A E A +  + ++  L+G  + +  + +E +   R                 
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELK 656
             +  A+     +K + DL+   L+ +  IK  ++ + +LRK LQ ++K
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK-LQAQMK 1655



 Score =  118 bits (295), Expect = 2e-26
 Identities = 162/750 (21%), Positives = 317/750 (42%), Gaps = 148/750 (19%)

Query: 50   SSSREDLSSQLLRRN----------EQIRKLEARLSDYAEQVRNLQKIKEKLE---IALE 96
            S  +EDL S+   RN          E++  L+  L D  +     Q+++ K E     L+
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180

Query: 97   KHQDSSMRKFQEQNETFQANRAKMAEGLALALAR---------KDQEWSEKMD------- 140
            K  D   R  + Q +  +   A+  E L   L +         K+++  EK +       
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240

Query: 141  --------QLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE 192
                    ++E +K  L AQ+QE++++  +  + R E+++     Q E+  +  ML + E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300

Query: 193  ESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKT 252
                K+ +++ + + +L  TQE L    +   ++S KL +L+   ++L++Q D  + +K 
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360

Query: 253  GAE---------------------SKITALEQKEQELQALIQQLSIDLQKVTAETQEKED 291
              E                     S + ALE+ ++  Q  I+ L+   ++  A   + E 
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 292  VITHLQEKVASL------EKRLEQNLSGEEHV--QELLKEKTLAEQNLEDTRQQLLAARS 343
                LQ+++  L      +++L  NL  ++    Q L +EK ++ +  ++  +    AR 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 344  SQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALA 403
             + KA++      R LE+ L+A EE  + +K + A  E  +       +    +++   A
Sbjct: 1481 KETKALSL----ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536

Query: 404  LEQQFLE---RTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQN 460
            LE Q  E   + + LE ++ A E  +   +   +    Q E++  A  E   E  R LQ 
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596

Query: 461  --HQFELKKLKEEWSQREIVSVAMA---------------------QALEEVRK---QRE 494
              H++E + L++E  QR + + A                       +A++++RK   Q +
Sbjct: 1597 QLHEYETE-LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 495  EFQQQAANLTAIIDE-------KEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQA 547
            +FQ++  +  A  DE        E+  +     L+Q ++++   ER    A L+  +L  
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715

Query: 548  EL-------EALRTLKAE-EAAVVAEQEDLLRLRGPL------------QAEALS----- 582
            EL        AL+  K   EA +   +E+L   +G +            QAE LS     
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775

Query: 583  ------VNES-----HVTSRAMQDPVFQLPTAGRTP-NGEVGAMDLTQLQKEKQDLEQQL 630
                   NES        ++ ++  + ++  A ++     + A++    Q E+Q +EQ+ 
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-VEQEA 1834

Query: 631  LEKN---KTIKQMQQRMLELRKTLQKELKI 657
             EK    K++KQ  +++ E+   ++ E K+
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKM 1864



 Score =  105 bits (263), Expect = 1e-22
 Identities = 144/645 (22%), Positives = 288/645 (44%), Gaps = 87/645 (13%)

Query: 60   LLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRK--FQEQNETFQANR 117
            LL+   Q  +++A+  +  +     QK + +L+   +KH   +  K   QEQ +      
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 118  AKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQ 177
            A+ AE + + LA K QE  E + ++E       A+L+E +++   L   R +M       
Sbjct: 904  AE-AEEMRVRLAAKKQELEEILHEME-------ARLEEEEDRGQQLQAERKKM------- 948

Query: 178  QQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELM----NSNQMSSD---LSQKL 230
             Q++  ++  L ++E +  K++ E      ++ + ++E++     +N++S +   L +++
Sbjct: 949  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008

Query: 231  EELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKE 290
             +L  + +  EE+  ++   K   ES I+ LE + ++ +   Q+L    +K+  +  +  
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 291  DVITHLQEKVASLEKRLEQNLSGEEHVQELLK--EKTLAEQN--------LEDTRQQLLA 340
            + I  LQ ++A L+ +L +    EE +Q  L   +  +A++N        LE     L  
Sbjct: 1069 EQIADLQAQIAELKMQLAKK---EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 341  ARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQ 400
               S+  A N  E + R+L + L+A + +L+ +    A Q    QEL A  ++   V ++
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ----QELRAKREQEVTVLKK 1181

Query: 401  AL---------ALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENA------ 445
            AL          +++   +  QA+E     LE+ + A +   ++  + LE+ENA      
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGEL 1240

Query: 446  -ALKECRNEYERSLQNHQFELKKLKEEWS----------------QREIVSVAMAQALEE 488
              L + + E E   +  + ++++L+ + S                Q E+ SV     L E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV--TGMLNE 1298

Query: 489  VRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAE 548
               +  +  +  A+L++ + + ++ L+E+T   L    ++ QLE   NS  LQ  QL  E
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS--LQ-DQLDEE 1355

Query: 549  LEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPN 608
            +EA + L+   + +  +  D    +  LQ  A +V       +  Q  +  L     T  
Sbjct: 1356 MEAKQNLERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIENL-----TQQ 1407

Query: 609  GEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
             E  A    +L+K K  L+Q+L +    +   +Q +  L K  +K
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452



 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 139/660 (21%), Positives = 279/660 (42%), Gaps = 105/660 (15%)

Query: 4    KLKKKIAEETAVA-QRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLR 62
            KL+ ++   T +  +  G A ++ + V+  S++S   D+  +   + +  + ++S++L +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVA--SLSSQLQDT-QELLQEETRQKLNVSTKLRQ 1340

Query: 63   RNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAE 122
              E+   L+ +L +  E  +NL++    L I L   +   ++ F    E  +  + +  +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK-KKLQDFASTVEALEEGKKRFQK 1399

Query: 123  GLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELS 182
             +   L ++ +E +   D+LEK KN L  +L ++     N  Q    +++ +    Q L+
Sbjct: 1400 EIE-NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458

Query: 183  KIKHMLLKKEESLGKME---QELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYST 239
            + K++  K  +   + E   +E E +   L+R  EE + +           EEL+R    
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK----------EELERTNKM 1508

Query: 240  LEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEK 299
            L+ + + +++SK      +  LE+ ++ L+  ++++   L+++  E Q  ED    L+  
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568

Query: 300  VASLEKRLEQNLSG-----EEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLET 354
            + +L+ + E++L       EE  ++L ++    E  LED R+Q   A +++ K    L+ 
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 355  RVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHV-------QQQALALEQQ 407
               + +  ++  EE ++Q + + A  +   +EL  A      +       +++A +LE  
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688

Query: 408  FLERTQALEAQIVALERTR----------AADQTTAEQGMRQLEQENAALKECRNEYERS 457
             ++    L+  + A ER R          A +  ++  G   L+ E   L+    + E  
Sbjct: 1689 LMQ----LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 458  LQNHQFELKKLK----------EEWSQREIVSVAMAQALEEVRKQRE------------- 494
            L+  Q  ++ +           E+ S       + AQ  E  R+Q E             
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804

Query: 495  ------EFQQQAANLTAII----DEKEQNLREKT--------------EVLLQKEQEILQ 530
                  +F+   A L A I    ++ EQ  REK               E+LLQ E E   
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864

Query: 531  LERGHNSA---LLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESH 587
             E+    A     ++ QL+ +LE     +AEE     E + +   R  LQ E     ES+
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLE-----EAEE-----ESQRINANRRKLQRELDEATESN 1914



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 115/539 (21%), Positives = 236/539 (43%), Gaps = 82/539 (15%)

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMA 121
            R  +++  L   L +  + V NL+K + K +  L + ++ S  K+ ++ +  +A  A+  
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYADERDRAEAE-AREK 1481

Query: 122  EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQEL 181
            E  AL+LAR  +E  E  ++LE+   +L A+++++ +   ++ +   E+++ +   + ++
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 182  SKIKHMLLKKEESL------------------GKMEQELEART-----------RELSRT 212
             ++K  L + E+ L                  G+ E++L+AR            R+L   
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 213  QEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALI 272
            + EL +  +  +  +   ++L+     LE Q D  I  +  A  ++  L+ + ++ Q  +
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 273  QQLSIDLQKVTAETQEKEDV-------ITHLQEKVASLEK-RLEQNLSGEEHVQELLKEK 324
            +       ++ A  +E E         +  LQE +A+ E+ R + +L  EE  +EL    
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-- 1719

Query: 325  TLAEQNLEDTRQQLLAARSSQAKA--------INTLETRVRELEQTLQASEEQLQQSKGI 376
            +L+ +N     ++ L AR +Q +         +  +  RVR+  Q  +    +L   +  
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779

Query: 377  VAAQETQIQELAAANQE-SSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQ 435
                E+  Q+L   N+E  S + +   A++ +F     ALEA+I  LE          EQ
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE----------EQ 1829

Query: 436  GMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREE 495
              ++  ++ AA K  + +            KKLKE   Q           +E+ RK  E+
Sbjct: 1830 VEQEAREKQAATKSLKQKD-----------KKLKEILLQ-----------VEDERKMAEQ 1867

Query: 496  FQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRT 554
            +++QA    A + + ++ L E  E   +      +L+R  + A      +  E+ AL++
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 111/534 (20%), Positives = 229/534 (42%), Gaps = 62/534 (11%)

Query: 182  SKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLE 241
            +K+K +L      + + E+E++A+  EL +T+E    +     +L QK  +L    + L+
Sbjct: 839  TKVKPLL-----QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ 893

Query: 242  EQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVA 301
            EQ          AE     L  K+QEL+ ++ ++   L++     Q+ +     + +++ 
Sbjct: 894  EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953

Query: 302  SLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA---ARSSQAKAINTLETRVRE 358
             LE++LE+    E   Q+L  EK  AE  ++    ++L      +  +K    LE R+ +
Sbjct: 954  DLEEQLEEE---EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010

Query: 359  LEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQ-------FLER 411
            L   L   EE+ +    +    E+ I EL    ++    +Q+   L+++       F E+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 412  TQALEAQIVALERTRAADQTTAEQGMRQLE----QENAALKECRNEYERSLQNHQFELKK 467
               L+AQI  L+   A  +   +  + +L+    Q+N ALK+ R E E  + + Q +L  
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDS 1129

Query: 468  LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQK--- 524
             +   ++ E     + + LE ++ + E+     A    +  ++EQ +    + L ++   
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189

Query: 525  -EQEILQLERGHNSALLQI-HQLQAELEALRTLKAEEAAVVAEQEDL---LRLRGPLQAE 579
             E ++ ++ + H  A+ ++  QL+    A   L   +  +  E  DL   LR+ G  + E
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 580  A------LSVNESHVTSRA---------MQDPVFQLPTAGRTPNGEVG---------AMD 615
                   L      + S+          + D V +L     +  G +          A D
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 616  LTQLQKEKQDLEQQLLEKNK-------TIKQMQQRMLELRKTLQKELKIRPDNE 662
            +  L  + QD ++ L E+ +        ++Q+++    L+  L +E++ + + E
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 43/181 (23%), Positives = 76/181 (41%), Gaps = 50/181 (27%)

Query: 486 LEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQL 545
           L +V +Q EE Q            KE  L++  E   + E E+ +LE+ H+    + + L
Sbjct: 844 LLQVTRQEEEMQA-----------KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892

Query: 546 QAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGR 605
           Q +L+A       E  + AE E++ R+R   + + L      + +R              
Sbjct: 893 QEQLQA-------ETELYAEAEEM-RVRLAAKKQELEEILHEMEARL------------- 931

Query: 606 TPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFE 665
                          +E++D  QQL  + K   +M Q+ML+L + L++E   R   +L +
Sbjct: 932 ---------------EEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEAARQKLQLEK 973

Query: 666 V 666
           V
Sbjct: 974 V 974


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  119 bits (299), Expect = 8e-27
 Identities = 159/742 (21%), Positives = 318/742 (42%), Gaps = 84/742 (11%)

Query: 48   DGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKL--EIALEKHQDSSMRK 105
            +  +  E +  Q+  ++++I+ LEA L    E +  L+K +E L  +I   + + + + +
Sbjct: 506  EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565

Query: 106  FQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQ 165
             QE+N T Q    ++ E L        Q      DQ++++K    A L+  +++ ++L  
Sbjct: 566  LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK----AHLRAAQDRVLSLET 621

Query: 166  RRDEMDELEGFQQQELSKIKHMLLKKEESL-----------GKMEQELEARTRELSRTQE 214
              +E++      ++++S++   +  K E L             ++  L+     L   Q+
Sbjct: 622  SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681

Query: 215  ELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQ 274
            EL         ++ KL++ Q H S LE             + K  +LEQK +EL+  I++
Sbjct: 682  ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY-------KEKYLSLEQKTEELEGQIKK 734

Query: 275  LSIDLQKVTA-------ETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLA 327
            L  D  +V A       + Q++  + T L+ +   L K+LE         +  L++K+ A
Sbjct: 735  LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794

Query: 328  EQNLED--TRQQLLAARSSQAKAINTLETRVR--ELEQTLQASEEQLQQSKGIVAAQETQ 383
             ++++   T+Q+       Q     + ET+++  EL   +Q +  +LQ+ K     +E  
Sbjct: 795  LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK---MEKEAL 851

Query: 384  IQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERT---------RAADQTTAE 434
            + EL+    + S V       + +F +  Q  +A I+ LE+T            + T  E
Sbjct: 852  MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911

Query: 435  QG--MRQLEQENAA---LKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEV 489
            Q    + LE+E  A   LK   N  +  L   Q  LK+ ++E  Q +     + Q+ E+ 
Sbjct: 912  QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971

Query: 490  RKQREEFQQQ----AANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQL 545
            +KQ E  Q +        T + ++ +Q L +  + L  ++++I  L+  +  +     QL
Sbjct: 972  KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL 1031

Query: 546  QA-----ELEALRT---LKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPV 597
            Q+     E E L T   LK+ E  +   QEDL+  R  +  +   + E       ++   
Sbjct: 1032 QSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ-- 1089

Query: 598  FQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKI 657
                +A +    +     L  +QKEK   E++L+ +   + +++            E+K 
Sbjct: 1090 ---DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE------------EIKC 1134

Query: 658  RPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLI 717
            R + E+ ++ E+     ++   S+   T+L DA+++  +    +  K  S + +      
Sbjct: 1135 RQEKEITKLNEE---LKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191

Query: 718  KAVSVLLNFSQEEENMLKETLE 739
                +     +EEE + KE +E
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIE 1213



 Score =  119 bits (298), Expect = 1e-26
 Identities = 172/793 (21%), Positives = 333/793 (41%), Gaps = 121/793 (15%)

Query: 32  ESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSD---YAEQVRN-LQKI 87
           E+V   G DSG    S+ +  R+D++  LLR  ++++ L+A L +   Y+E+++  L+K 
Sbjct: 61  EAVHDAGNDSGHGGESNLALKRDDVT--LLR--QEVQDLQASLKEEKWYSEELKKELEKY 116

Query: 88  K--------------------EKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALA 127
           +                    + LE  LE+ Q  +    ++  + F+   A++A  +A  
Sbjct: 117 QGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFN-IKQMKDLFEQKAAQLATEIADI 175

Query: 128 LARKDQEWS------EKMDQLEKEKNILTAQLQEMKNQSMN-------------LFQRRD 168
            ++ D+E S      +K+ +L +E N     +Q++K + +              L Q + 
Sbjct: 176 KSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT 235

Query: 169 EMDELEGFQQQELSKIKHMLLKKEES--------------LGKMEQELEARTRELSRTQE 214
            MD +   +++E  K+K    K +                L K  QE+    +EL + + 
Sbjct: 236 LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295

Query: 215 ELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQ 274
            +    Q +  L++ L + ++ Y+ LEE+ +    SK   ++ +   +   Q+LQ+ +  
Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355

Query: 275 LSIDLQKVTAETQEKEDVITHLQEKVASLEKRL-----------EQNLSGEEHVQELLKE 323
               L ++  E  EK +    L+E+++ +E +            +Q    E+H  +L  E
Sbjct: 356 SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415

Query: 324 KTLAEQNLEDTRQQLLAA-------RSSQAKAINTLETRVRELEQTLQASEEQLQQSKGI 376
                  L +T +QL  A       R   ++ +   E +V +L+  L   EEQL++    
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475

Query: 377 VAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAE-Q 435
               + Q+ +    +QE   +QQ   A   +  E    LE     L +    DQ     +
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTA---KLREAQNDLEQ---VLRQIGDKDQKIQNLE 529

Query: 436 GMRQLEQENAALKEC-RNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQRE 494
            + Q  +EN +L E  R +    +Q  + E   L +   +   +   + Q  E+++ Q E
Sbjct: 530 ALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSE 589

Query: 495 EFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEA-LR 553
             +Q   NL   + E++ +LR   + +L  E  + +L    N +  ++ QL  +++A   
Sbjct: 590 SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649

Query: 554 TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGA 613
            L + EAA  A++ DL              N       A+QD   +L             
Sbjct: 650 LLLSAEAAKTAQRADL-------------QNHLDTAQNALQDKQQELNKI---------T 687

Query: 614 MDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLEL-RKTLQKELKIRP-DNELFEVREKPG 671
             L Q+  + QD ++   +    +K+ +++ L L +KT + E +I+  + +  EV+    
Sbjct: 688 TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE 747

Query: 672 PEMANMAPSVTNNTDL-TDAREIN--FEYLKHVV--LKFMSCRESEAFHLIKAVSVLLNF 726
             + ++      NTDL   A E++   E  K +V   +    ++SEA   IK     L  
Sbjct: 748 QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ---KLTK 804

Query: 727 SQEEENMLKETLE 739
            +EE+ +LK+  E
Sbjct: 805 QEEEKQILKQDFE 817



 Score =  111 bits (277), Expect = 3e-24
 Identities = 139/647 (21%), Positives = 286/647 (44%), Gaps = 68/647 (10%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQN 110
            +S  +L+SQL    E++ +L+ ++    E + + +  K      L+ H D++    Q++ 
Sbjct: 621  TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680

Query: 111  ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEM 170
            +       ++ +  A     K Q+  E   QLE       + L+E K + ++L Q+ +E+
Sbjct: 681  QELNKITTQLDQVTA-----KLQDKQEHCSQLE-------SHLKEYKEKYLSLEQKTEEL 728

Query: 171  D----ELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQE---ELMNSNQMS 223
            +    +LE     E+   K   L+  +   ++  +LE R  ELS+  E   E+++S ++ 
Sbjct: 729  EGQIKKLEA-DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL- 786

Query: 224  SDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVT 283
             DL +K E L+     L +Q +     K   E+     + + +EL   IQ    +LQKV 
Sbjct: 787  -DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK 845

Query: 284  AETQEKEDVITHLQEKVASLEKRLE--------QNLSGEEHVQELLKEKTLAEQNLEDTR 335
             E +     ++ +++K++ +   L+        +N  G+  + +L K     +  L+   
Sbjct: 846  MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905

Query: 336  QQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESS 395
            +  L  +    K++   +    +L+  L + +EQL Q++  +   E + Q+L     E  
Sbjct: 906  ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965

Query: 396  HVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYE 455
               +Q    +++ +E  Q  E +I  L++T   ++   +Q + Q  QE AA KE  +  +
Sbjct: 966  QSSEQ----KKKQIEALQG-ELKIAVLQKTELENKL--QQQLTQAAQELAAEKEKISVLQ 1018

Query: 456  RSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQ-------QAANLTAIID 508
             + +  Q   K+L+ ++  RE   +A  Q L+ V ++    Q+       Q  N   +I 
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078

Query: 509  E--------------KEQNLREKTEVL--LQKEQEILQLER-GHNSALLQIHQLQAELEA 551
            E              KEQ L+E+ + L  +QKE+ + + E     S L +I +++   E 
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138

Query: 552  LRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEV 611
              T K  E     + E +  +     A+ L + +       +Q     L  A        
Sbjct: 1139 EIT-KLNEELKSHKLESIKEITNLKDAKQLLIQQK----LELQGKADSLKAAVEQEKRNQ 1193

Query: 612  GAMDLTQLQKEKQDLEQQLLEKN-KTIKQMQQRMLELRKTLQKELKI 657
              +   Q++KE+++L+++ +EK  K   +++++ + ++K  + E K+
Sbjct: 1194 QILK-DQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 123/575 (21%), Positives = 252/575 (43%), Gaps = 89/575 (15%)

Query: 50   SSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALE-KHQDSSMRKFQE 108
            SS+R DL     +++E +  ++ +L+   E+ + L++  E L    + +H++ + R    
Sbjct: 782  SSTRLDLQ----KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI--- 834

Query: 109  QNETFQANRAKMA-EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRR 167
            Q    +  + KM  E L   L+    + S+  D L+  K+    + Q+ K   ++L +  
Sbjct: 835  QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894

Query: 168  DEMDELEGFQQQ----ELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS 223
             E+      Q +    E  ++K  L K++E+  +++ EL +   +L + Q  L  + +  
Sbjct: 895  KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954

Query: 224  SDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVT 283
              L   + EL++      EQ+   I +  G E KI  L++ E E   L QQL+   Q++ 
Sbjct: 955  QQLQGNINELKQS----SEQKKKQIEALQG-ELKIAVLQKTELE-NKLQQQLTQAAQELA 1008

Query: 284  AETQEKEDVITHLQEKVASLEKRLEQNLSGEEH--------VQELLKEKTLAEQNLEDTR 335
            AE +EK  V+ +  EK     K+L+ +  G E         ++ + ++ +LA+++L   R
Sbjct: 1009 AE-KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067

Query: 336  QQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQS---------------------- 373
             Q+     +Q K I  L+T    LEQ     E+QLQ+                       
Sbjct: 1068 NQI----GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123

Query: 374  ------KGIVAAQETQI----QELAAANQES----SHVQQQALALEQQFLERTQALEAQI 419
                  + I   QE +I    +EL +   ES    ++++     L QQ LE     ++  
Sbjct: 1124 SKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK 1183

Query: 420  VALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVS 479
             A+E+ +   Q   +Q  ++ E+      E   +    ++  +  +KK +E  ++  +  
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243

Query: 480  VAMAQALEEVRKQREEFQQQAANL----------TAIIDEKEQNLREKTEVLLQK----- 524
             A+ + L  V+K+ +  Q++ + L           A+++   QN +++   LL++     
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303

Query: 525  ------EQEILQLERGHNSALLQIHQLQAELEALR 553
                  + ++L+L+R  ++    + +L  E ++L+
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 51/264 (19%), Positives = 121/264 (45%), Gaps = 19/264 (7%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQ--VRNLQKIKEKLEIA-LEKHQDSSMRKFQ 107
            +++  L     ++ +Q+++    L D  ++  ++  + + EK ++A +E+ +    ++  
Sbjct: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT 1141

Query: 108  EQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRR 167
            + NE  ++++ +  + +      K     +K++   K  ++  A  QE +NQ +   Q +
Sbjct: 1142 KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201

Query: 168  DEMDEL-------EGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSN 220
             E +EL       E     E+ + +  + K EE+  K+  ++ A    L   ++E  +S 
Sbjct: 1202 KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ 1261

Query: 221  QMSSDLSQKLEELQRHYSTLE-------EQRDHVIASKTGAESKITALEQKEQELQALIQ 273
            +  S+L ++ ++L+   + LE       ++R  ++      E +I  L+ K  ELQ  + 
Sbjct: 1262 RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321

Query: 274  QLSIDLQKVTAETQEKEDVITHLQ 297
              +  +Q++  E Q  +  I H Q
Sbjct: 1322 NTTAAVQELGRENQSLQ--IKHTQ 1343


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  119 bits (297), Expect = 1e-26
 Identities = 143/605 (23%), Positives = 280/605 (46%), Gaps = 63/605 (10%)

Query: 46   ASDGSSSREDLSSQLLRRNEQIRKLE----ARLSDYAEQVRNLQKIKEKLEIALEKHQDS 101
            +S+G S  + L  QL    +QI+ LE    A  S  +   R LQ  + KL    E   + 
Sbjct: 737  SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV 796

Query: 102  SMRKFQEQNETFQANRAKMAEGL--ALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQ 159
            S  K   + E  Q  + K AE    A+++ R  QE   K+ Q E++ N+L++ L++++  
Sbjct: 797  SQVKETLEKE-LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 855

Query: 160  SMNL---FQRRDEMDE----LEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRT 212
              ++   F+ +DE +E     +   + ++++I  M       L KM  EL  + R++   
Sbjct: 856  LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL 915

Query: 213  QEELMNSNQMSSDLSQKLEEL--QRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQA 270
            Q +L  +N+ +S L + +E++  +   S  E  + H    K   E K++ LE+K +    
Sbjct: 916  QLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHE-EEKKELERKLSDLEKKMETSHN 974

Query: 271  LIQQLSIDLQKVTAETQEK-EDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQ 329
              Q+L    ++ T+ET+ K E+++ +LQ+ +   E +L+      E    LL+E      
Sbjct: 975  QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLK---GAREENSGLLQE------ 1025

Query: 330  NLEDTRQQLLAARSSQA--KAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQEL 387
             LE+ R+Q   A+++Q    A+  +E   +E  +TL AS E  +Q+   +  +   ++E 
Sbjct: 1026 -LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETL-ASLEDTKQTNAKLQNELDTLKEN 1083

Query: 388  AAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAAL 447
               N E  +  ++ L +E Q +E       +I  L++  A       Q +  L++EN  L
Sbjct: 1084 NLKNVEELNKSKELLTVENQKMEE---FRKEIETLKQAAA----QKSQQLSALQEENVKL 1136

Query: 448  KECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAII 507
             E        + +HQ    KL+EE   R +++  + +  +   K  ++  ++ A+L   I
Sbjct: 1137 AEELGRSRDEVTSHQ----KLEEE---RSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1189

Query: 508  DEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQE 567
                  L EK   L +   E+  L RG N++   +H +      ++TL++++  +  + +
Sbjct: 1190 SITSALLTEKDAELEKLRNEVTVL-RGENASAKSLHSV------VQTLESDKVKLELKVK 1242

Query: 568  DLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMD--LTQLQKEKQD 625
            + L L+       LS +  +  ++A +D         R    ++  ++  +  LQ++ QD
Sbjct: 1243 N-LELQLKENKRQLSSSSGNTDTQADEDE--------RAQESQIDFLNSVIVDLQRKNQD 1293

Query: 626  LEQQL 630
            L+ ++
Sbjct: 1294 LKMKV 1298



 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/773 (21%), Positives = 343/773 (44%), Gaps = 115/773 (14%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQN 110
            SS   ++S +  R  +   L    S YA ++     ++E L+   +  +     +  E+ 
Sbjct: 317  SSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERA 376

Query: 111  ETFQANR--AKMAEGLALALARKDQ---EWSEKMDQL-------EKEKNILTAQLQEMKN 158
            E  +A     ++ + LALA    DQ   E   KMDQL       ++EK  L  QL+E K 
Sbjct: 377  EVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKR 436

Query: 159  QSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMN 218
            +  +L  R +E    +G        ++   + ++  + ++E++L  R +E++  +  L  
Sbjct: 437  KVEDLQFRVEEESITKG-------DLEVATVSEKSRIMELEKDLALRVQEVAELRRRL-E 488

Query: 219  SNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQ----KEQELQALIQQ 274
            SN+ + D+   L  LQ   S+L+E+ +    ++T  + +IT+L++    +E+  Q  I+ 
Sbjct: 489  SNKPAGDVDMSLSLLQ-EISSLQEKLE---VTRTDHQREITSLKEHFGAREETHQKEIKA 544

Query: 275  LSIDLQKVTAETQEKEDVITHLQEK----VASLEKRLEQNLSGEEHVQELLKE------- 323
            L    +K++ E +  +  + H  ++    +A  + +LE  ++  +   E LK        
Sbjct: 545  LYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLG 604

Query: 324  ---------KTLAEQ-------NLEDTRQQLLAARSSQAKAINTLETR----VRELEQTL 363
                     KT  E+        +E+ + Q  + R++ AK +  L  +    ++E E +L
Sbjct: 605  TETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 664

Query: 364  QASEEQLQQSKG--IVAAQET--QIQELAAANQESSHVQ---QQALALEQQFLERTQALE 416
            +A   +L +++   +V  ++T  ++QE     +E   +Q    +   +   F  + +A E
Sbjct: 665  EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATE 724

Query: 417  AQIVALERTRAADQ-------------TTAEQGMRQLEQENAALKECRNEYERSLQNHQF 463
             +++ L+  R A                 AE+ ++ LE E  A     +   R LQ  + 
Sbjct: 725  EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 784

Query: 464  ELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQ 523
            +L  L+E  S+   V   + + L+ ++++  E  ++A ++       +++++E    L Q
Sbjct: 785  KLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSV-------QRSMQETVNKLHQ 837

Query: 524  KEQEILQLERGHNSALLQIHQLQAELEALRTLK--AEEAAVVAEQE------DLLRLRGP 575
            KE++   L    +S L ++ +  A++EA    K   EE  + A+++      +++++ G 
Sbjct: 838  KEEQFNML----SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 893

Query: 576  LQAEALSVN-ESHVTSRAMQDPVFQLPTAGRTPNG-EVGAMDLTQLQKEKQDLEQQLLEK 633
              ++   +N E  +  R +++   +L  A    +  +    D+T   ++ Q    +  E+
Sbjct: 894  NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 953

Query: 634  NKTIKQMQQRMLELRKTLQ------KELKIRPDNELFEVREKPGPEMANMAPSVTNNTD- 686
             K  K++++++ +L K ++      +ELK R +    E + K    + N+  ++ +  D 
Sbjct: 954  EK--KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1011

Query: 687  LTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENMLKETLE 739
            L  ARE N   L+   L+ +  +  +A    KA     +  Q  E M KE  E
Sbjct: 1012 LKGAREENSGLLQE--LEELRKQADKA----KAAQTAEDAMQIMEQMTKEKTE 1058



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 131/640 (20%), Positives = 272/640 (42%), Gaps = 115/640 (17%)

Query: 69   KLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSS----MRKFQEQNETFQANRAKM--AE 122
            ++E    DY  ++ NLQ  ++    A  K  ++     M+  +E+  + +A R+K+  AE
Sbjct: 616  QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE 675

Query: 123  GLALA----LARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQ 178
               L        K QE   K+ +LE  +     Q + + N +  L    +++ +L+  ++
Sbjct: 676  DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 735

Query: 179  ------QELSKIKHMLLKKEESLGKMEQELEAR-------TRELSRTQEELMNSNQMSSD 225
                   E+ K++  L   E+ +  +E E  A        TREL   + +L N  +  S+
Sbjct: 736  ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 795

Query: 226  LSQKLEELQRHYSTLEEQ----RDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQK 281
            +SQ  E L++    L+E+     +  ++ +   +  +  L QKE++       LS DL+K
Sbjct: 796  VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN----MLSSDLEK 851

Query: 282  VTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAA 341
                          L+E +A +E +  +    +E  ++L+K    A++ LE+   +++  
Sbjct: 852  --------------LRENLADMEAKFREK---DEREEQLIK----AKEKLENDIAEIMKM 890

Query: 342  RSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQA 401
                +  +  +   +R  E+ ++  + +L ++    +  +  I+++    ++S   QQ+A
Sbjct: 891  SGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS---QQEA 947

Query: 402  LALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNH 461
                +   E  + LE ++  LE+         ++   + E+   A  E + ++E  LQN 
Sbjct: 948  AKKHE---EEKKELERKLSDLEKKMETSHNQCQELKARYER---ATSETKTKHEEILQNL 1001

Query: 462  QFELKKLKEEWSQREIVSVAMAQALEEVRKQREE-----------------FQQQAANLT 504
            Q  L   +++       +  + Q LEE+RKQ ++                  +++   L 
Sbjct: 1002 QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA 1061

Query: 505  AIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALL------QIHQLQAELEALRTLKAE 558
            ++ D K+ N + + E+   KE  +  +E  + S  L      ++ + + E+E L+   A+
Sbjct: 1062 SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1121

Query: 559  EA-AVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLT 617
            ++  + A QE+ ++L     AE L  +   VTS                           
Sbjct: 1122 KSQQLSALQEENVKL-----AEELGRSRDEVTSH-------------------------Q 1151

Query: 618  QLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKI 657
            +L++E+  L  QLLE  K   +  +   E + +LQK + I
Sbjct: 1152 KLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISI 1191



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 148/757 (19%), Positives = 308/757 (40%), Gaps = 94/757 (12%)

Query: 55   DLSSQLLRRNEQIR-KLEARLSDYAEQVRNLQKIKEKLEIALEKHQD------SSMRKFQ 107
            D+S  LL+    ++ KLE   +D+  ++ +L   KE      E HQ       ++  K  
Sbjct: 497  DMSLSLLQEISSLQEKLEVTRTDHQREITSL---KEHFGAREETHQKEIKALYTATEKLS 553

Query: 108  EQNETFQ-----ANR------AKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEM 156
            ++NE+ +     AN+      A     L  A+A   Q   E      K     TA+  E+
Sbjct: 554  KENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL 613

Query: 157  KNQSMNLFQRRDEMDELEGFQQQELS--------------KIKHMLLKKEESLGKMEQEL 202
            K Q   +  R D   E+E  Q Q+ S              K+  ++ +KE SL  +  +L
Sbjct: 614  KTQIEKM--RLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 671

Query: 203  EARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALE 262
            +    +     E+ +N  Q +    ++LE LQ   +   +  D+  +     E K+  L+
Sbjct: 672  DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 731

Query: 263  --------------QKEQELQALIQQLS-IDLQKVTAETQEKEDVITHLQEKVASLEKRL 307
                          +  Q+L+A  +Q+  ++++K  AE+ +   +   LQ +   L   L
Sbjct: 732  ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK-NAESSKASSITRELQGRELKL-TNL 789

Query: 308  EQNLSGEEHVQELL-KEKTLAEQNLEDTRQQLLAARSSQAKAINTLE------------- 353
            ++NLS    V+E L KE  + ++   +  ++ ++ + S  + +N L              
Sbjct: 790  QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL 849

Query: 354  TRVRELEQTLQAS-------EEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQ 406
             ++RE    ++A        EEQL ++K  +     +I +++  N          L L++
Sbjct: 850  EKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909

Query: 407  QFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFEL- 465
            + +E    L+ ++       +  Q + E    + EQ      +   E ++ L+    +L 
Sbjct: 910  RDVEE---LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 966

Query: 466  KKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKE 525
            KK++   +Q + +     +A  E + + EE  Q         ++K +  RE+   LLQ+ 
Sbjct: 967  KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1026

Query: 526  QEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNE 585
            +E+    R            +  ++ +  +  E+   +A  ED  +    LQ E  ++ E
Sbjct: 1027 EEL----RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082

Query: 586  SHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRML 645
            +++ +    +   +L T        V    + + +KE + L+Q   +K++ +  +Q+  +
Sbjct: 1083 NNLKNVEELNKSKELLT--------VENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1134

Query: 646  ELRKTLQKEL-KIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLK 704
            +L + L +   ++    +L E R     ++  M    +      D  + + +    +   
Sbjct: 1135 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1194

Query: 705  FMSCRESEAFHLIKAVSVLL--NFSQEEENMLKETLE 739
             ++ +++E   L   V+VL   N S +  + + +TLE
Sbjct: 1195 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLE 1231



 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 142/657 (21%), Positives = 280/657 (42%), Gaps = 111/657 (16%)

Query: 189 LKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVI 248
           L    S+        +RT  L+ T          ++ L + L+E Q+H   L  +RD   
Sbjct: 316 LSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLER 375

Query: 249 ASKTGAESKITALEQK-----------EQELQALIQQLSIDLQKVTAETQEKEDVITHLQ 297
           A    A S +  +EQ+             EL+A + QL      V A  +EK +++  L+
Sbjct: 376 AEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR---TMVEAADREKVELLNQLE 432

Query: 298 E---KVASLEKRLEQ-----------NLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARS 343
           E   KV  L+ R+E+            +S +  + EL K+  L  Q + + R++L + + 
Sbjct: 433 EEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKP 492

Query: 344 --------SQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESS 395
                   S  + I++L+ ++       Q     L++  G  A +ET  +E+ A    + 
Sbjct: 493 AGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFG--AREETHQKEIKALYTATE 550

Query: 396 HVQQQALALEQQFLERTQALEAQIVALERTRAADQTTA-EQGMRQLE--------QENAA 446
            + ++  +L+ + LE      + ++AL +++      + +Q M +L+         E A 
Sbjct: 551 KLSKENESLKSK-LEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAE 609

Query: 447 LKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVR-KQREEFQQQAANLTA 505
             E + + E+   ++Q E++ L+   +Q++    A A+ +E +R K  +  +++  +L A
Sbjct: 610 FAELKTQIEKMRLDYQHEIENLQ---NQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA 666

Query: 506 I---IDEKE-QNLREKTEVLLQ--------KEQEILQLERGHNSALLQ--IHQLQAELEA 551
           I   +D+ E Q+L E  + L +        KE E+LQ +    + ++     QL+A  E 
Sbjct: 667 IRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEK 726

Query: 552 LRTLKAEEAAVVAEQEDLLRLRGPLQA-----EALSVNESHVTSRA-------------- 592
           L  L A   A    + ++ +LR  L+A     + L + ++  +S+A              
Sbjct: 727 LLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKL 786

Query: 593 --MQDPVFQLPTAGRTPNGEV---------GAMDLTQLQKEKQDLEQQLLEKNKTIKQMQ 641
             +Q+ + ++     T   E+          + +   +Q+  Q+   +L +K +    + 
Sbjct: 787 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 846

Query: 642 QRMLELRKTL-QKELKIRPDNE----LFEVREKPGPEMAN-MAPSVTNNTDLT---DARE 692
             + +LR+ L   E K R  +E    L + +EK   ++A  M  S  N++ LT   D   
Sbjct: 847 SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR 906

Query: 693 INFEYLKHVVLKFMSCRESEAF--HLIKAVSVLLNFSQEE----ENMLKETLEYKMS 743
           +    ++ + LK     E+ +F    I+ ++V    SQ+E        K+ LE K+S
Sbjct: 907 LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 963


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  119 bits (297), Expect = 1e-26
 Identities = 143/605 (23%), Positives = 280/605 (46%), Gaps = 63/605 (10%)

Query: 46   ASDGSSSREDLSSQLLRRNEQIRKLE----ARLSDYAEQVRNLQKIKEKLEIALEKHQDS 101
            +S+G S  + L  QL    +QI+ LE    A  S  +   R LQ  + KL    E   + 
Sbjct: 772  SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV 831

Query: 102  SMRKFQEQNETFQANRAKMAEGL--ALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQ 159
            S  K   + E  Q  + K AE    A+++ R  QE   K+ Q E++ N+L++ L++++  
Sbjct: 832  SQVKETLEKE-LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 890

Query: 160  SMNL---FQRRDEMDE----LEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRT 212
              ++   F+ +DE +E     +   + ++++I  M       L KM  EL  + R++   
Sbjct: 891  LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL 950

Query: 213  QEELMNSNQMSSDLSQKLEEL--QRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQA 270
            Q +L  +N+ +S L + +E++  +   S  E  + H    K   E K++ LE+K +    
Sbjct: 951  QLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHE-EEKKELERKLSDLEKKMETSHN 1009

Query: 271  LIQQLSIDLQKVTAETQEK-EDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQ 329
              Q+L    ++ T+ET+ K E+++ +LQ+ +   E +L+      E    LL+E      
Sbjct: 1010 QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLK---GAREENSGLLQE------ 1060

Query: 330  NLEDTRQQLLAARSSQA--KAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQEL 387
             LE+ R+Q   A+++Q    A+  +E   +E  +TL AS E  +Q+   +  +   ++E 
Sbjct: 1061 -LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETL-ASLEDTKQTNAKLQNELDTLKEN 1118

Query: 388  AAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAAL 447
               N E  +  ++ L +E Q +E       +I  L++  A       Q +  L++EN  L
Sbjct: 1119 NLKNVEELNKSKELLTVENQKMEE---FRKEIETLKQAAA----QKSQQLSALQEENVKL 1171

Query: 448  KECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAII 507
             E        + +HQ    KL+EE   R +++  + +  +   K  ++  ++ A+L   I
Sbjct: 1172 AEELGRSRDEVTSHQ----KLEEE---RSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1224

Query: 508  DEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQE 567
                  L EK   L +   E+  L RG N++   +H +      ++TL++++  +  + +
Sbjct: 1225 SITSALLTEKDAELEKLRNEVTVL-RGENASAKSLHSV------VQTLESDKVKLELKVK 1277

Query: 568  DLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMD--LTQLQKEKQD 625
            + L L+       LS +  +  ++A +D         R    ++  ++  +  LQ++ QD
Sbjct: 1278 N-LELQLKENKRQLSSSSGNTDTQADEDE--------RAQESQIDFLNSVIVDLQRKNQD 1328

Query: 626  LEQQL 630
            L+ ++
Sbjct: 1329 LKMKV 1333



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 131/640 (20%), Positives = 272/640 (42%), Gaps = 115/640 (17%)

Query: 69   KLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSS----MRKFQEQNETFQANRAKM--AE 122
            ++E    DY  ++ NLQ  ++    A  K  ++     M+  +E+  + +A R+K+  AE
Sbjct: 651  QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE 710

Query: 123  GLALA----LARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQ 178
               L        K QE   K+ +LE  +     Q + + N +  L    +++ +L+  ++
Sbjct: 711  DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770

Query: 179  ------QELSKIKHMLLKKEESLGKMEQELEAR-------TRELSRTQEELMNSNQMSSD 225
                   E+ K++  L   E+ +  +E E  A        TREL   + +L N  +  S+
Sbjct: 771  ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830

Query: 226  LSQKLEELQRHYSTLEEQ----RDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQK 281
            +SQ  E L++    L+E+     +  ++ +   +  +  L QKE++       LS DL+K
Sbjct: 831  VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN----MLSSDLEK 886

Query: 282  VTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAA 341
                          L+E +A +E +  +    +E  ++L+K    A++ LE+   +++  
Sbjct: 887  --------------LRENLADMEAKFREK---DEREEQLIK----AKEKLENDIAEIMKM 925

Query: 342  RSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQA 401
                +  +  +   +R  E+ ++  + +L ++    +  +  I+++    ++S   QQ+A
Sbjct: 926  SGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS---QQEA 982

Query: 402  LALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNH 461
                +   E  + LE ++  LE+         ++   + E+   A  E + ++E  LQN 
Sbjct: 983  AKKHE---EEKKELERKLSDLEKKMETSHNQCQELKARYER---ATSETKTKHEEILQNL 1036

Query: 462  QFELKKLKEEWSQREIVSVAMAQALEEVRKQREE-----------------FQQQAANLT 504
            Q  L   +++       +  + Q LEE+RKQ ++                  +++   L 
Sbjct: 1037 QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA 1096

Query: 505  AIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALL------QIHQLQAELEALRTLKAE 558
            ++ D K+ N + + E+   KE  +  +E  + S  L      ++ + + E+E L+   A+
Sbjct: 1097 SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1156

Query: 559  EA-AVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLT 617
            ++  + A QE+ ++L     AE L  +   VTS                           
Sbjct: 1157 KSQQLSALQEENVKL-----AEELGRSRDEVTSH-------------------------Q 1186

Query: 618  QLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKI 657
            +L++E+  L  QLLE  K   +  +   E + +LQK + I
Sbjct: 1187 KLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISI 1226



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 169/800 (21%), Positives = 346/800 (43%), Gaps = 134/800 (16%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQN 110
            SS   ++S +  R  +   L    S YA ++     ++E L+   +  +     +  E+ 
Sbjct: 317  SSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERA 376

Query: 111  ETFQANR--AKMAEGLALALARKDQ---EWSEKMDQL-------EKEKNILTAQLQEMKN 158
            E  +A     ++ + LALA    DQ   E   KMDQL       ++EK  L  QL+E K 
Sbjct: 377  EVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKR 436

Query: 159  QSMNLFQRRDEMDELEG-------FQQQELSKIKHMLLKKEESLGKMEQELE----ARTR 207
            +  +L  R +E    +G        +   + +++  LL ++    K+++ELE    A   
Sbjct: 437  KVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVS 496

Query: 208  ELSRTQE----------------ELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASK 251
            E SR  E                  + SN+ + D+   L  LQ   S+L+E+ +    ++
Sbjct: 497  EKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQ-EISSLQEKLE---VTR 552

Query: 252  TGAESKITALEQ----KEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEK----VASL 303
            T  + +IT+L++    +E+  Q  I+ L    +K++ E +  +  + H  ++    +A  
Sbjct: 553  TDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALW 612

Query: 304  EKRLEQNLSGEEHVQELLKE----------------KTLAEQ-------NLEDTRQQLLA 340
            + +LE  ++  +   E LK                 KT  E+        +E+ + Q  +
Sbjct: 613  KSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS 672

Query: 341  ARSSQAKAINTLETR----VRELEQTLQASEEQLQQSKG--IVAAQET--QIQELAAANQ 392
             R++ AK +  L  +    ++E E +L+A   +L +++   +V  ++T  ++QE     +
Sbjct: 673  ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 732

Query: 393  ESSHVQ---QQALALEQQFLERTQALEAQIVALERTRAADQ-------------TTAEQG 436
            E   +Q    +   +   F  + +A E +++ L+  R A                 AE+ 
Sbjct: 733  ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 792

Query: 437  MRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEF 496
            ++ LE E  A     +   R LQ  + +L  L+E  S+   V   + + L+ ++++  E 
Sbjct: 793  IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852

Query: 497  QQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLK 556
             ++A ++       +++++E    L QKE++   L    +S L ++ +  A++EA    K
Sbjct: 853  SEEAVSV-------QRSMQETVNKLHQKEEQFNML----SSDLEKLRENLADMEAKFREK 901

Query: 557  --AEEAAVVAEQE------DLLRLRGPLQAEALSVN-ESHVTSRAMQDPVFQLPTAGRTP 607
               EE  + A+++      +++++ G   ++   +N E  +  R +++   +L  A    
Sbjct: 902  DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA 961

Query: 608  NG-EVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQ------KELKIRPD 660
            +  +    D+T   ++ Q    +  E+ K  K++++++ +L K ++      +ELK R +
Sbjct: 962  SFLQKSIEDMTVKAEQSQQEAAKKHEEEK--KELERKLSDLEKKMETSHNQCQELKARYE 1019

Query: 661  NELFEVREKPGPEMANMAPSVTNNTD-LTDAREINFEYLKHVVLKFMSCRESEAFHLIKA 719
                E + K    + N+  ++ +  D L  ARE N   L+   L+ +  +  +A    KA
Sbjct: 1020 RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE--LEELRKQADKA----KA 1073

Query: 720  VSVLLNFSQEEENMLKETLE 739
                 +  Q  E M KE  E
Sbjct: 1074 AQTAEDAMQIMEQMTKEKTE 1093



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 148/757 (19%), Positives = 308/757 (40%), Gaps = 94/757 (12%)

Query: 55   DLSSQLLRRNEQIR-KLEARLSDYAEQVRNLQKIKEKLEIALEKHQD------SSMRKFQ 107
            D+S  LL+    ++ KLE   +D+  ++ +L   KE      E HQ       ++  K  
Sbjct: 532  DMSLSLLQEISSLQEKLEVTRTDHQREITSL---KEHFGAREETHQKEIKALYTATEKLS 588

Query: 108  EQNETFQ-----ANR------AKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEM 156
            ++NE+ +     AN+      A     L  A+A   Q   E      K     TA+  E+
Sbjct: 589  KENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL 648

Query: 157  KNQSMNLFQRRDEMDELEGFQQQELS--------------KIKHMLLKKEESLGKMEQEL 202
            K Q   +  R D   E+E  Q Q+ S              K+  ++ +KE SL  +  +L
Sbjct: 649  KTQIEKM--RLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 706

Query: 203  EARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALE 262
            +    +     E+ +N  Q +    ++LE LQ   +   +  D+  +     E K+  L+
Sbjct: 707  DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 766

Query: 263  --------------QKEQELQALIQQLS-IDLQKVTAETQEKEDVITHLQEKVASLEKRL 307
                          +  Q+L+A  +Q+  ++++K  AE+ +   +   LQ +   L   L
Sbjct: 767  ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK-NAESSKASSITRELQGRELKL-TNL 824

Query: 308  EQNLSGEEHVQELL-KEKTLAEQNLEDTRQQLLAARSSQAKAINTLE------------- 353
            ++NLS    V+E L KE  + ++   +  ++ ++ + S  + +N L              
Sbjct: 825  QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL 884

Query: 354  TRVRELEQTLQAS-------EEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQ 406
             ++RE    ++A        EEQL ++K  +     +I +++  N          L L++
Sbjct: 885  EKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 944

Query: 407  QFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFEL- 465
            + +E    L+ ++       +  Q + E    + EQ      +   E ++ L+    +L 
Sbjct: 945  RDVEE---LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 1001

Query: 466  KKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKE 525
            KK++   +Q + +     +A  E + + EE  Q         ++K +  RE+   LLQ+ 
Sbjct: 1002 KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061

Query: 526  QEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNE 585
            +E+    R            +  ++ +  +  E+   +A  ED  +    LQ E  ++ E
Sbjct: 1062 EEL----RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117

Query: 586  SHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRML 645
            +++ +    +   +L T        V    + + +KE + L+Q   +K++ +  +Q+  +
Sbjct: 1118 NNLKNVEELNKSKELLT--------VENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1169

Query: 646  ELRKTLQKEL-KIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLK 704
            +L + L +   ++    +L E R     ++  M    +      D  + + +    +   
Sbjct: 1170 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1229

Query: 705  FMSCRESEAFHLIKAVSVLL--NFSQEEENMLKETLE 739
             ++ +++E   L   V+VL   N S +  + + +TLE
Sbjct: 1230 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLE 1266



 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 146/605 (24%), Positives = 252/605 (41%), Gaps = 89/605 (14%)

Query: 189 LKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVI 248
           L    S+        +RT  L+ T          ++ L + L+E Q+H   L  +RD   
Sbjct: 316 LSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLER 375

Query: 249 ASKTGAESKITALEQK-----------EQELQALIQQLSIDLQKVTAETQEKEDVITHLQ 297
           A    A S +  +EQ+             EL+A + QL      V A  +EK +++  L+
Sbjct: 376 AEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR---TMVEAADREKVELLNQLE 432

Query: 298 E---KVASLEKRLEQN--LSGE-------EHV------QELLKEKTLA---EQNLEDTRQ 336
           E   KV  L+ R+E+     G+       EH       Q LL EKT A   ++ LEDTR 
Sbjct: 433 EEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRV 492

Query: 337 QLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQE--- 393
             ++ +S   +    L  RV+E+ +  +  E    +  G V    + +QE+++  ++   
Sbjct: 493 ATVSEKSRIMELEKDLALRVQEVAELRRRLES--NKPAGDVDMSLSLLQEISSLQEKLEV 550

Query: 394 -SSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKEC-- 450
             +  Q++  +L++ F  R +  + +I AL           E    +LE  N    +   
Sbjct: 551 TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610

Query: 451 --RNEYERSLQNHQFELKKLKEEWSQREIVSVA-MAQALEEVRKQREEFQQQAANLTAII 507
             +++ E ++ +HQ  +++LK  +S+      A  A+   ++ K R ++Q +  NL    
Sbjct: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL---- 666

Query: 508 DEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTL--KAEEAAVVAE 565
               QN ++       KE E L+ +      +  I + +  LEA+R+   KAE+  +V E
Sbjct: 667 ----QNQQDSERAAHAKEMEALRAK-----LMKVIKEKENSLEAIRSKLDKAEDQHLV-E 716

Query: 566 QEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPT-AGRTPNGEVGAMDLTQLQK--- 621
            ED L     LQ   + V E  V      +    +     +    E   +DL  L+K   
Sbjct: 717 MEDTL---NKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 773

Query: 622 ----EKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANM 677
               E + L QQL    K IK      LE+ K  +         EL + RE    ++ N+
Sbjct: 774 EGKSEMKKLRQQLEAAEKQIKH-----LEIEKNAESSKASSITREL-QGREL---KLTNL 824

Query: 678 APSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLN-FSQEEE--NML 734
             +++  + + +  E   + LK    KF    E EA  + +++   +N   Q+EE  NML
Sbjct: 825 QENLSEVSQVKETLEKELQILKE---KFAEASE-EAVSVQRSMQETVNKLHQKEEQFNML 880

Query: 735 KETLE 739
              LE
Sbjct: 881 SSDLE 885


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score =  117 bits (294), Expect = 3e-26
 Identities = 154/721 (21%), Positives = 326/721 (45%), Gaps = 96/721 (13%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKI------KEKLEIALEKHQD 100
            ++  ++++DL S+ + +  +++ L ++L+D     + L++        E+  +  E+   
Sbjct: 509  AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQ 568

Query: 101  SSMRKFQEQNETFQA-------------NRAKMAEGLALALARKDQEWSEKMDQLEKEKN 147
              ++   EQNE  +A             + + +AE L   +A KD++  +  D L  E++
Sbjct: 569  MQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD 628

Query: 148  ILTAQLQEMKN-QSMNLFQRRDEMDELEGFQQQ------ELSKIKHMLLKKEESLGKMEQ 200
             LT++ +E+K+ Q+MN F  + E+ +L+    +      EL K++  +  K++ +  +E+
Sbjct: 629  RLTSKEEELKDIQNMN-FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE 687

Query: 201  ELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITA 260
            +L+    E+S   EE    N  +  L  ++++LQ   + + EQ      +K   E     
Sbjct: 688  QLQ---HEISNKMEEFKILNDQNKALKSEVQKLQ---TLVSEQ-----PNKDVVEQMEKC 736

Query: 261  LEQKEQELQALIQQLSIDLQKVTAETQEKEDVITH---LQEKVASLEKRLEQNLSGEEHV 317
            +++K+++L+ + + L   L +V  + +E   + T    L ++V  L+ +    +S    V
Sbjct: 737  IQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV 796

Query: 318  QELLK---EKTLAEQNLEDTRQQLLAARSSQAKAIN-TLETRVRELEQTLQASEEQLQQS 373
            +EL K   EK    +++E+  +  L   +++ K +  ++ ++V+EL+  L+  EEQ+   
Sbjct: 797  EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTM 856

Query: 374  KGIVAAQETQ-------IQELAAANQE-SSHVQQQALALEQQFLERTQALEAQIV----- 420
            K ++  +E         +Q+L   N+   +HVQ+ A    ++    +Q  E +IV     
Sbjct: 857  KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKE 916

Query: 421  -------ALERTRAADQTTAEQGMRQLEQEN-------AALKECRNEYERSLQNHQFELK 466
                   A+ + R +D ++  Q ++ ++ EN         LK+   +   S   H+  LK
Sbjct: 917  NELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLK 976

Query: 467  KLKEEWSQREIVSV-----AMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVL 521
             + E   ++EI  +     ++  A+E  RK+  + +++       +   E+ L++K    
Sbjct: 977  VISER--EKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKT 1034

Query: 522  LQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEAL 581
             ++ Q+  Q+E     A   + +L  ++     L   E     E++    + G   +E +
Sbjct: 1035 SKERQQ--QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV 1092

Query: 582  SVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQ-------LLEKN 634
             V E  +        + QL          V A     LQK ++ +EQ+       + E +
Sbjct: 1093 KVLEHKLKEADEMHTLLQLEC---EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH 1149

Query: 635  KTIKQMQQRMLELRKTLQKELKIRPDNELFE--VREKPGPEMANMAPSVTNNTDLTDARE 692
            KTIKQMQ       + L+   ++R +N+  E   RE+   EM      +  +T +T+ RE
Sbjct: 1150 KTIKQMQSSFTSSEQELE---RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRE 1206

Query: 693  I 693
            +
Sbjct: 1207 L 1207



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 133/647 (20%), Positives = 280/647 (43%), Gaps = 81/647 (12%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRK-FQEQNET 112
            E L  ++  + E+ + L  +      +V+ LQ +  +      K     M K  QE++E 
Sbjct: 687  EQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQP---NKDVVEQMEKCIQEKDEK 743

Query: 113  FQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDE 172
             +     +  GL + +A K++E    ++ +  E + LT ++Q++K +  +       ++E
Sbjct: 744  LKTVEELLETGL-IQVATKEEE----LNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE 798

Query: 173  LEGFQQQELSKIKHM-------LLK---KEESL----------------GKMEQELEART 206
            L+    ++  KIK +       LLK   KE+++                GK E+++    
Sbjct: 799  LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGK-EEQMNTMK 857

Query: 207  RELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQ 266
              L   +++L N+ +   DL ++ E L+ H   + +      +S +  E     L++KE 
Sbjct: 858  AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 917

Query: 267  E---LQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKE 323
            E   L+A++++   DL   T   Q+ +D     + ++  L+++  Q  S     +ELLK 
Sbjct: 918  ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 977

Query: 324  KTLAEQNLEDTRQQLLAARSS---QAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQ 380
             +  E+ +     +L + + +   Q K  N L  +  E  + L AS E++ Q K    ++
Sbjct: 978  ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL-ASTEKMLQDKVNKTSK 1036

Query: 381  ETQIQELAAANQESSHVQQQ-----ALALEQQFLERTQALE--AQIVALERTRAADQTTA 433
            E Q Q++ A   E+  V ++     ++     + E     E  A+      + + +    
Sbjct: 1037 ERQ-QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL 1095

Query: 434  EQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIV-SVAMAQALEEVRKQ 492
            E  +++ ++ +  L+    +Y+  L   +  L+KL+    Q E    V + ++ + +++ 
Sbjct: 1096 EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM 1155

Query: 493  REEFQQQAANLTAIIDEKE--QNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAEL- 549
            +  F      L  +  E +  +NLR + E L   E E+ + E   ++ + ++ +L+A+L 
Sbjct: 1156 QSSFTSSEQELERLRSENKDIENLRREREHL---EMELEKAEMERSTYVTEVRELKAQLN 1212

Query: 550  EALRTLKAEEAAVVAEQEDLLRLRGPLQ--AEALSVNESHVTSRAMQDPVFQLPTAGRTP 607
            E L  L+        EQ +  ++ G L    ++L + +S +   A    V +        
Sbjct: 1213 ETLTKLR-------TEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIE-------- 1257

Query: 608  NGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKE 654
            N +V        + E  + E   +  N+T+ Q+QQ +  + + L KE
Sbjct: 1258 NSDVSP------ETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1298



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 132/667 (19%), Positives = 270/667 (40%), Gaps = 77/667 (11%)

Query: 41  SGDDFASDGSSSRED--LSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKH 98
           +G+   SD  S   D  LS  L   ++Q+  +   + + +  VR  +K ++K +  LE+ 
Sbjct: 69  NGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQ 128

Query: 99  --QDSSMRKFQEQN-ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQE 155
             ++S   K   +  E     +       A A  +K  +   K    +++K + T  +  
Sbjct: 129 VIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPS 188

Query: 156 MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEE 215
            + +++ L Q   E  +  G  +++ S  K    +K E++   E  + A T         
Sbjct: 189 KRQEALPLHQ---ETKQESGSGKKKASSKK----QKTENVFVDEPLIHATT------YIP 235

Query: 216 LMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL 275
           LM+ N  SS +  K E +      L+  +   I  K+G +   T  +++  E++   +  
Sbjct: 236 LMD-NADSSPVVDKREVID----LLKPDQVEGI-QKSGTKKLKTETDKENAEVK--FKDF 287

Query: 276 SIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGE-----EHVQELLKEKTLAEQN 330
            + L+ +     E   V+  L+EK   ++  L+++  GE       +QE  K+K LA   
Sbjct: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQE--KDKLLAAVK 345

Query: 331 -----LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQ 385
                 +D  +QL     ++ +  N + TR+++   TL+  E  + Q+K  V+ QETQ  
Sbjct: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE-KEHNVFQNKIHVSYQETQQM 404

Query: 386 ELA------AANQESSHVQQQ------ALALEQQFLERTQALEAQIVALERTRAADQTT- 432
           ++           E +H++Q+      A++     LE  Q+ E   +  +  R  ++ T 
Sbjct: 405 QMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTE 464

Query: 433 --------------AEQGMR----QLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQ 474
                         AEQ       QL++     +E ++   +    H+   + L+ ++  
Sbjct: 465 KTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVA 524

Query: 475 REIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERG 534
           +E    ++   L +    +++ +Q+   L     E EQ    K E L  + Q+IL+    
Sbjct: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLM----ESEQKRVNKEESLQMQVQDILEQNEA 580

Query: 535 HNSALLQIHQLQAELEALRTLKAEEAAVVAEQE-DLLRLRGPLQAEALSVNESHVTSRAM 593
             + + Q H   A   +   L  E   V+AE++  + +    L +E   +       + +
Sbjct: 581 LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDI 640

Query: 594 QDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
           Q+  F L         +  A +      E + ++Q +  K+  I+ +++++        +
Sbjct: 641 QNMNFLL--KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698

Query: 654 ELKIRPD 660
           E KI  D
Sbjct: 699 EFKILND 705



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 79/346 (22%), Positives = 141/346 (40%), Gaps = 43/346 (12%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQK----IKEKLEIALEKH-------QDSS 102
            E+L   +  R ++I  L   L    + V + +K    ++EK   A+E         QD  
Sbjct: 972  EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1031

Query: 103  MRKFQEQNETFQANRAKMAEGLALALARKDQ-------EWSEKMDQLEKEKNILTAQLQE 155
             +  +E+ +  +A   +  E L     +          EW    ++  KE    T+  +E
Sbjct: 1032 NKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1091

Query: 156  MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELS-RTQE 214
            +K     L  +  E DE+    Q E  K K +L + E  L K+++ +E    +   +  E
Sbjct: 1092 VKV----LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDE 1147

Query: 215  ELMNSNQMSSDLSQKLEELQRHYS------TLEEQRDHVIASKTGAESKITALEQKEQEL 268
                  QM S  +   +EL+R  S       L  +R+H+      AE + +    + +EL
Sbjct: 1148 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL 1207

Query: 269  QALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAE 328
            +A   QL+  L K+  E  E++ V   L +   SLE  L Q+   +      + E +   
Sbjct: 1208 KA---QLNETLTKLRTEQNERQKVAGDLHKAQQSLE--LIQSKIVKAAGDTTVIENSDVS 1262

Query: 329  QNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSK 374
               E + ++ ++   +Q          V +L+Q LQA  +QL + K
Sbjct: 1263 PETESSEKETMSVSLNQT---------VTQLQQLLQAVNQQLTKEK 1299



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 52/240 (21%), Positives = 107/240 (44%), Gaps = 35/240 (14%)

Query: 87   IKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEK 146
            ++ KL+ A E H  + ++   E+ ++  A    + + L  ++ +++ +W  K+D+  K  
Sbjct: 1095 LEHKLKEADEMH--TLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK-- 1150

Query: 147  NILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEART 206
                     +K    +      E++ L    + E   I+++  ++E     +E ELE   
Sbjct: 1151 --------TIKQMQSSFTSSEQELERL----RSENKDIENLRREREH----LEMELEKAE 1194

Query: 207  RELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQ 266
             E S    E+    ++ + L++ L +L+    T + +R  V      A+  +  ++ K  
Sbjct: 1195 MERSTYVTEV---RELKAQLNETLTKLR----TEQNERQKVAGDLHKAQQSLELIQSK-- 1245

Query: 267  ELQALIQQLSIDLQKVTAETQ--EKEDVITHLQEKVASLEKRLE---QNLSGE-EHVQEL 320
             ++A      I+   V+ ET+  EKE +   L + V  L++ L+   Q L+ E EH Q L
Sbjct: 1246 IVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1305


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  117 bits (294), Expect = 3e-26
 Identities = 158/751 (21%), Positives = 316/751 (42%), Gaps = 91/751 (12%)

Query: 6    KKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSRED----LSSQLL 61
            K+K A E  V         +  +++K +              D   + ED    L+   +
Sbjct: 972  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI 1031

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMA 121
            +  +Q+  LE  L    +   +L++ K KLE  L+  Q+S M    E+ +  +  + K  
Sbjct: 1032 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091

Query: 122  E------------GLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
            E             L + L +K +E   ++++LE+E     A   + + Q  +L +  +E
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151

Query: 170  MDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS-SDLSQ 228
            + E         S    M  K+E    KM ++LE  T +   T   L   +  S ++L +
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211

Query: 229  KLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQE 288
            +++ LQR    LE+++  +        S +  + + +  L+ + + L   L ++ ++ +E
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271

Query: 289  KEDVIT-------HLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQL--- 338
            ++ +I         LQ +     ++L++    E  V +L + K    Q +E+ ++QL   
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSRQLDEK---EALVSQLSRGKQAFTQQIEELKRQLEEE 1328

Query: 339  LAARSSQAKAINTLE---TRVRELEQTLQASEEQLQQ--SKGIVAAQETQIQELAAANQE 393
            + A+++ A A+ +       +RE  +  Q S+ +LQ+  SK      + + +    A Q 
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388

Query: 394  SSHVQQQALALEQQFL---ERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAAL--- 447
            +  +++    L Q+     E  +A+ A+  +LE+T+   Q   E  M  +E+ NAA    
Sbjct: 1389 TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448

Query: 448  -KECRN-------------EYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQR 493
             K+ RN             E    L+  Q E + L  E  + +         LE ++++ 
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKREN 1508

Query: 494  EEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQ-----LQAE 548
            +  QQ+ ++LT  I E  + + E  ++  Q EQE  +L+     A   +       L+ +
Sbjct: 1509 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568

Query: 549  LEALRTLKAEEAAVVAEQEDLL------------RLRGPLQAEALSVNESHVTSRAMQDP 596
            LE L  +K+E    +AE+++ +             ++  L AE  S N++    + M+  
Sbjct: 1569 LE-LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627

Query: 597  VFQLPT-----------AGRTPNGEVGAMDLTQLQ-----KEKQDLEQQLLEKNKTIKQM 640
            + ++             A R      G +  TQ+      + ++DL++QL    +    +
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687

Query: 641  QQRMLELRKTLQKELKIR--PDNELFEVREK 669
            Q  + ELR TL++  + R   + EL +  E+
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASER 1718



 Score =  111 bits (278), Expect = 2e-24
 Identities = 139/602 (23%), Positives = 261/602 (43%), Gaps = 53/602 (8%)

Query: 76   DYAEQVRNLQKIKEKL--EIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQ 133
            + A      QKIK++L    A  K  +  M    ++    Q      AEGLA A      
Sbjct: 854  EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA------ 907

Query: 134  EWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEE 193
               E+ DQL K K  L A+++E+  ++ +  +   E+   +   + E S++K  +   E 
Sbjct: 908  --EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965

Query: 194  SLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQR-HYSTLEEQRDHVIASKT 252
            +L K+E+E  A   ++    EE+   ++  + L+++ + LQ  H  TL++ +       T
Sbjct: 966  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025

Query: 253  GAESKITALEQKEQELQALIQQ---LSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQ 309
              ++KI  LEQ+  +L+  ++Q   L +DL++     ++ E  +   QE +  +E   +Q
Sbjct: 1026 LTKAKIK-LEQQVDDLEGSLEQEKKLRMDLERAK---RKLEGDLKLAQESIMDIENEKQQ 1081

Query: 310  NLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQ 369
                   + E LK+K     NL+   +   A      K I  L+ R+ ELE+ ++A    
Sbjct: 1082 -------LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERAS 1134

Query: 370  LQQSKGIVAAQETQIQELAAANQESSHVQQQALAL----EQQFLERTQALEAQIVALERT 425
              +++   +    +++E++   +E+       + +    E +F +  + LE   +  E T
Sbjct: 1135 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1194

Query: 426  RAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVA---- 481
             A  +      + +L ++   L+  + + E+     + E+  L    S  E VS A    
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA---SNVETVSKAKGNL 1251

Query: 482  ------MAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGH 535
                  +   L E++ + EE Q+   +LTA     +    E +  L +KE  + QL RG 
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311

Query: 536  NSALLQIHQLQAELEALRTLKAEEA---AVVAEQEDLLRLRGPLQAEALSVNESHVTSRA 592
             +   QI +L+ +LE    +KA+ A   A+ + + D   LR   + E  S  E       
Sbjct: 1312 QAFTQQIEELKRQLE--EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 593  MQDPVFQLPTAGRTPNGEVGAMDLT-QLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTL 651
                V Q  T       E  A+  T +L++ K+ L Q+L    + ++ +  +   L KT 
Sbjct: 1370 ANTEVAQWRT-----KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 652  QK 653
            Q+
Sbjct: 1425 QR 1426



 Score =  104 bits (259), Expect = 4e-22
 Identities = 146/712 (20%), Positives = 308/712 (43%), Gaps = 90/712 (12%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQ-DSSMRK 105
            ++ +   E+++++L  +    RKLE   S+  + + +L+    K+E   EKH  ++ ++ 
Sbjct: 929  TERAEDEEEINAELTAKK---RKLEDECSELKKDIDDLELTLAKVE--KEKHATENKVKN 983

Query: 106  FQEQNETFQANRAKMA-EGLALALARKD-----QEWSEKMDQLEKEKNILTAQLQEMKNQ 159
              E+        AK+  E  AL  A +      Q   +K++ L K K  L  Q+ +++  
Sbjct: 984  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS 1043

Query: 160  SMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNS 219
                 + R +++  +   + +L   +  ++  E    +++++L+ +  E+S  Q ++ + 
Sbjct: 1044 LEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE 1103

Query: 220  NQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLS--- 276
              +   L +K++ELQ     LEE+ +   AS+  AE + + L ++ +E+   +++     
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1163

Query: 277  -----------IDLQKVTAETQEK----EDVITHLQEKVASLEKRLEQNLSGEEHV-QEL 320
                        + QK+  + +E     E     L++K A     L + +   + V Q+L
Sbjct: 1164 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223

Query: 321  LKEKTLAEQNLEDTR---QQLLAARSSQAKAINTLETRVRELEQT----------LQASE 367
             KEK+  +  ++D     + +  A+ +  K   TLE ++ EL+            L A  
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283

Query: 368  EQLQQSKGIVAAQ----ETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALE 423
             +LQ   G  + Q    E  + +L+   Q  +   QQ   L++Q  E  +A  A   AL+
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFT---QQIEELKRQLEEEIKAKNALAHALQ 1340

Query: 424  RTR----------AADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWS 473
             +R            +Q +  +  R L + N  + + R +YE        EL++ K++ +
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLA 1400

Query: 474  QREIVSVAMAQALE----EVRKQREEFQQQAANL----------TAIIDEKEQNLREKTE 519
            QR   +    +A+      + K ++  Q +  +L           A +D+K++N  +   
Sbjct: 1401 QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460

Query: 520  VLLQK-EQEILQLERGHNSA------LLQIHQLQAE-LEALRTLKAEEAAVVAEQEDLLR 571
               QK E+   +LE     A      L +I     E L+ L TLK E   +  E  DL  
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520

Query: 572  --LRGPLQAEALSVNESHVTSR--AMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLE 627
                G  +   L   +  V      +Q  + +   +     G++  + L +L + K +++
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL-ELNQVKSEVD 1579

Query: 628  QQLLEKNKTIKQMQQRMLELRKTLQKEL--KIRPDNELFEVREKPGPEMANM 677
            +++ EK++ I Q+++  + + +++Q  L  +IR  N+   +++K   ++  M
Sbjct: 1580 RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 118/523 (22%), Positives = 232/523 (44%), Gaps = 87/523 (16%)

Query: 188  LLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHV 247
            LLK  E+    E+E+     E  + ++EL  S     +L +K+  L      L+E+ D  
Sbjct: 845  LLKSAET----EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL------LKEKNDLQ 894

Query: 248  IASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLE--- 304
            +  +  AE    A E+ +Q ++  IQ L   +++VT   +++E++   L  K   LE   
Sbjct: 895  LQVQAEAEGLADAEERCDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 953

Query: 305  KRLEQNLSG-EEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTL 363
              L++++   E  + ++ KEK   E  +++  +++             L+  + +L +  
Sbjct: 954  SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG-----------LDETIAKLTKEK 1002

Query: 364  QASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALE 423
            +A +E  QQ+   + A+E ++  L  A  +   ++QQ   LE   LE+ + L   +   +
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIK---LEQQVDDLEGS-LEQEKKLRMDLERAK 1058

Query: 424  RTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFEL-----------KKLKEEW 472
            R    D   A++ +  +E E   L E   + E  + N Q ++           KK+KE  
Sbjct: 1059 RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQ 1118

Query: 473  SQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLRE-------KTEVLLQKE 525
            ++ E     + + +E  R  R + ++Q ++L+  ++E  + L E       + E+  ++E
Sbjct: 1119 ARIE----ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1174

Query: 526  QEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQ-EDLLRLRGPLQAEA---- 580
             E  ++ R    A L   Q +A    LR   A+  A + EQ ++L R++  L+ E     
Sbjct: 1175 AEFQKMRRDLEEATL---QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1231

Query: 581  -----LSVNESHVTS---------RAMQDPVFQLPTAGRTPNGEVGAMDLT----QLQKE 622
                 L+ N   V+          R ++D + +L +        +   DLT    +LQ E
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN--DLTAQRGRLQTE 1289

Query: 623  KQDLEQQLLEKNKTIKQMQ-------QRMLELRKTLQKELKIR 658
              +  +QL EK   + Q+        Q++ EL++ L++E+K +
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 144/730 (19%), Positives = 294/730 (40%), Gaps = 107/730 (14%)

Query: 5    LKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRN 64
            L +++ E +   +  GGAT     ++K+  A                 R DL    L+  
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEF------------QKMRRDLEEATLQHE 1192

Query: 65   EQIRKLEARLSD----YAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKM 120
                 L  + +D      EQ+ NLQ++K+KLE      ++ S  K +  +          
Sbjct: 1193 ATAATLRKKHADSVAELGEQIDNLQRVKQKLE------KEKSEMKMEIDDLASNVETVSK 1246

Query: 121  AEGLALALARKDQEWSEKMDQLEKEK----NILTAQLQEMKNQSMNLFQRRDEMDEL--- 173
            A+G    + R  ++   ++   E+E+    N LTAQ   ++ +S    ++ DE + L   
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306

Query: 174  -----EGFQQQELSKIKHML---LKKEESLG---------------KMEQELEART---R 207
                 + F QQ + ++K  L   +K + +L                + E+E E++    R
Sbjct: 1307 LSRGKQAFTQQ-IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365

Query: 208  ELSRTQEELMN-SNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQ 266
             LS+   E+     +  +D  Q+ EEL+     L ++            +K  +LE+ +Q
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQ 1425

Query: 267  ELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTL 326
             LQ  ++ L +D+++  A           L +K  + +K L +    ++  +E   E   
Sbjct: 1426 RLQNEVEDLMLDVERTNA-------ACAALDKKQRNFDKILAE---WKQKCEETHAELEA 1475

Query: 327  AEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQE 386
            +++       +L   +++  ++++ LET  RE +   Q   +  +Q    +A    +I E
Sbjct: 1476 SQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ----IAEGGKRIHE 1531

Query: 387  LAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAA 446
            L    ++   V+Q+   L+    E   +LE +   + R +        +  R++ +++  
Sbjct: 1532 LEKIKKQ---VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1588

Query: 447  LKECRNEYERSLQNHQFEL--------------KKLKEEWSQREI-VSVAMAQALEEVRK 491
            + + +  + R +++ Q  L              KK++ + ++ EI ++ A   A E +R 
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1648

Query: 492  QREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEA 551
             R        N   I+ + + +L +        ++++  +ER  N    +I +L+A LE 
Sbjct: 1649 YR--------NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700

Query: 552  L---RTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRA--MQDPVFQLPTAGRT 606
                R +  +E    +E+  LL  +           E+ ++     M+D + +   A   
Sbjct: 1701 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEK 1760

Query: 607  PNGEV--GAMDLTQLQKEKQD---LEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDN 661
                +   AM   +L+KE+     LE+      +T+K +Q R+ E  +   K  K +   
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQK 1820

Query: 662  ELFEVREKPG 671
                VRE  G
Sbjct: 1821 LEARVRELEG 1830



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 98/532 (18%), Positives = 217/532 (40%), Gaps = 102/532 (19%)

Query: 65   EQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGL 124
            ++  +  A L    ++ R+L     K++ A E+  D  +   + +N+  Q   + + E +
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ-LETLKRENKNLQQEISDLTEQI 1522

Query: 125  ALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQ-----------SMNLFQRRDEMDEL 173
            A    ++  E  +   Q+E+EK  L A L+E +              + L Q + E+D  
Sbjct: 1523 AEG-GKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1581

Query: 174  EGFQQQELSKIKHMLLKKEESL-GKMEQELEARTR----------ELSRTQEELMNSNQM 222
               + +E+ ++K   ++  ES+   ++ E+ +R            +L+  + +L ++N+M
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1641

Query: 223  SSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKV 282
            +++  +     Q      +   D  + S+   + ++  +E++   LQA I++L   L++ 
Sbjct: 1642 AAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT 1701

Query: 283  TAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAAR 342
                                                   + + +AEQ L D  +++    
Sbjct: 1702 E--------------------------------------RSRKIAEQELLDASERVQLLH 1723

Query: 343  SSQAKAINT---LETRVR----ELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESS 395
            +     INT   LET +     E+E  LQ +    +++K  +       +EL      S+
Sbjct: 1724 TQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783

Query: 396  HVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYE 455
            H+++    +EQ   +    L+           A+Q   + G +Q+++  A ++E   E E
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLD----------EAEQLALKGGKKQIQKLEARVRELEGEVE 1833

Query: 456  RSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLR 515
               + +   +K L++             + ++E+  Q EE ++    L  ++D+ +  ++
Sbjct: 1834 SEQKRNAEAVKGLRKH-----------ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882

Query: 516  EKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQE 567
                     +++  + E   N+ L +  +LQ ELE     +AEE A +AE +
Sbjct: 1883 -------SYKRQAEEAEEQSNTNLAKFRKLQHELE-----EAEERADIAESQ 1922


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  117 bits (294), Expect = 3e-26
 Identities = 158/751 (21%), Positives = 316/751 (42%), Gaps = 91/751 (12%)

Query: 6    KKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSRED----LSSQLL 61
            K+K A E  V         +  +++K +              D   + ED    L+   +
Sbjct: 972  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI 1031

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMA 121
            +  +Q+  LE  L    +   +L++ K KLE  L+  Q+S M    E+ +  +  + K  
Sbjct: 1032 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091

Query: 122  E------------GLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
            E             L + L +K +E   ++++LE+E     A   + + Q  +L +  +E
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151

Query: 170  MDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS-SDLSQ 228
            + E         S    M  K+E    KM ++LE  T +   T   L   +  S ++L +
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211

Query: 229  KLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQE 288
            +++ LQR    LE+++  +        S +  + + +  L+ + + L   L ++ ++ +E
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271

Query: 289  KEDVIT-------HLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQL--- 338
            ++ +I         LQ +     ++L++    E  V +L + K    Q +E+ ++QL   
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSRQLDEK---EALVSQLSRGKQAFTQQIEELKRQLEEE 1328

Query: 339  LAARSSQAKAINTLE---TRVRELEQTLQASEEQLQQ--SKGIVAAQETQIQELAAANQE 393
            + A+++ A A+ +       +RE  +  Q S+ +LQ+  SK      + + +    A Q 
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388

Query: 394  SSHVQQQALALEQQFL---ERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAAL--- 447
            +  +++    L Q+     E  +A+ A+  +LE+T+   Q   E  M  +E+ NAA    
Sbjct: 1389 TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448

Query: 448  -KECRN-------------EYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQR 493
             K+ RN             E    L+  Q E + L  E  + +         LE ++++ 
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKREN 1508

Query: 494  EEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQ-----LQAE 548
            +  QQ+ ++LT  I E  + + E  ++  Q EQE  +L+     A   +       L+ +
Sbjct: 1509 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568

Query: 549  LEALRTLKAEEAAVVAEQEDLL------------RLRGPLQAEALSVNESHVTSRAMQDP 596
            LE L  +K+E    +AE+++ +             ++  L AE  S N++    + M+  
Sbjct: 1569 LE-LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627

Query: 597  VFQLPT-----------AGRTPNGEVGAMDLTQLQ-----KEKQDLEQQLLEKNKTIKQM 640
            + ++             A R      G +  TQ+      + ++DL++QL    +    +
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687

Query: 641  QQRMLELRKTLQKELKIR--PDNELFEVREK 669
            Q  + ELR TL++  + R   + EL +  E+
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASER 1718



 Score =  111 bits (278), Expect = 2e-24
 Identities = 139/602 (23%), Positives = 261/602 (43%), Gaps = 53/602 (8%)

Query: 76   DYAEQVRNLQKIKEKL--EIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQ 133
            + A      QKIK++L    A  K  +  M    ++    Q      AEGLA A      
Sbjct: 854  EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA------ 907

Query: 134  EWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEE 193
               E+ DQL K K  L A+++E+  ++ +  +   E+   +   + E S++K  +   E 
Sbjct: 908  --EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965

Query: 194  SLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQR-HYSTLEEQRDHVIASKT 252
            +L K+E+E  A   ++    EE+   ++  + L+++ + LQ  H  TL++ +       T
Sbjct: 966  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025

Query: 253  GAESKITALEQKEQELQALIQQ---LSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQ 309
              ++KI  LEQ+  +L+  ++Q   L +DL++     ++ E  +   QE +  +E   +Q
Sbjct: 1026 LTKAKIK-LEQQVDDLEGSLEQEKKLRMDLERAK---RKLEGDLKLAQESIMDIENEKQQ 1081

Query: 310  NLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQ 369
                   + E LK+K     NL+   +   A      K I  L+ R+ ELE+ ++A    
Sbjct: 1082 -------LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERAS 1134

Query: 370  LQQSKGIVAAQETQIQELAAANQESSHVQQQALAL----EQQFLERTQALEAQIVALERT 425
              +++   +    +++E++   +E+       + +    E +F +  + LE   +  E T
Sbjct: 1135 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1194

Query: 426  RAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVA---- 481
             A  +      + +L ++   L+  + + E+     + E+  L    S  E VS A    
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA---SNVETVSKAKGNL 1251

Query: 482  ------MAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGH 535
                  +   L E++ + EE Q+   +LTA     +    E +  L +KE  + QL RG 
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311

Query: 536  NSALLQIHQLQAELEALRTLKAEEA---AVVAEQEDLLRLRGPLQAEALSVNESHVTSRA 592
             +   QI +L+ +LE    +KA+ A   A+ + + D   LR   + E  S  E       
Sbjct: 1312 QAFTQQIEELKRQLE--EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 593  MQDPVFQLPTAGRTPNGEVGAMDLT-QLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTL 651
                V Q  T       E  A+  T +L++ K+ L Q+L    + ++ +  +   L KT 
Sbjct: 1370 ANTEVAQWRT-----KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 652  QK 653
            Q+
Sbjct: 1425 QR 1426



 Score =  104 bits (259), Expect = 4e-22
 Identities = 146/712 (20%), Positives = 308/712 (43%), Gaps = 90/712 (12%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQ-DSSMRK 105
            ++ +   E+++++L  +    RKLE   S+  + + +L+    K+E   EKH  ++ ++ 
Sbjct: 929  TERAEDEEEINAELTAKK---RKLEDECSELKKDIDDLELTLAKVE--KEKHATENKVKN 983

Query: 106  FQEQNETFQANRAKMA-EGLALALARKD-----QEWSEKMDQLEKEKNILTAQLQEMKNQ 159
              E+        AK+  E  AL  A +      Q   +K++ L K K  L  Q+ +++  
Sbjct: 984  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS 1043

Query: 160  SMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNS 219
                 + R +++  +   + +L   +  ++  E    +++++L+ +  E+S  Q ++ + 
Sbjct: 1044 LEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE 1103

Query: 220  NQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLS--- 276
              +   L +K++ELQ     LEE+ +   AS+  AE + + L ++ +E+   +++     
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1163

Query: 277  -----------IDLQKVTAETQEK----EDVITHLQEKVASLEKRLEQNLSGEEHV-QEL 320
                        + QK+  + +E     E     L++K A     L + +   + V Q+L
Sbjct: 1164 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223

Query: 321  LKEKTLAEQNLEDTR---QQLLAARSSQAKAINTLETRVRELEQT----------LQASE 367
             KEK+  +  ++D     + +  A+ +  K   TLE ++ EL+            L A  
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283

Query: 368  EQLQQSKGIVAAQ----ETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALE 423
             +LQ   G  + Q    E  + +L+   Q  +   QQ   L++Q  E  +A  A   AL+
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFT---QQIEELKRQLEEEIKAKNALAHALQ 1340

Query: 424  RTR----------AADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWS 473
             +R            +Q +  +  R L + N  + + R +YE        EL++ K++ +
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLA 1400

Query: 474  QREIVSVAMAQALE----EVRKQREEFQQQAANL----------TAIIDEKEQNLREKTE 519
            QR   +    +A+      + K ++  Q +  +L           A +D+K++N  +   
Sbjct: 1401 QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460

Query: 520  VLLQK-EQEILQLERGHNSA------LLQIHQLQAE-LEALRTLKAEEAAVVAEQEDLLR 571
               QK E+   +LE     A      L +I     E L+ L TLK E   +  E  DL  
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520

Query: 572  --LRGPLQAEALSVNESHVTSR--AMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLE 627
                G  +   L   +  V      +Q  + +   +     G++  + L +L + K +++
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL-ELNQVKSEVD 1579

Query: 628  QQLLEKNKTIKQMQQRMLELRKTLQKEL--KIRPDNELFEVREKPGPEMANM 677
            +++ EK++ I Q+++  + + +++Q  L  +IR  N+   +++K   ++  M
Sbjct: 1580 RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 118/523 (22%), Positives = 232/523 (44%), Gaps = 87/523 (16%)

Query: 188  LLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHV 247
            LLK  E+    E+E+     E  + ++EL  S     +L +K+  L      L+E+ D  
Sbjct: 845  LLKSAET----EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL------LKEKNDLQ 894

Query: 248  IASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLE--- 304
            +  +  AE    A E+ +Q ++  IQ L   +++VT   +++E++   L  K   LE   
Sbjct: 895  LQVQAEAEGLADAEERCDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 953

Query: 305  KRLEQNLSG-EEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTL 363
              L++++   E  + ++ KEK   E  +++  +++             L+  + +L +  
Sbjct: 954  SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG-----------LDETIAKLTKEK 1002

Query: 364  QASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALE 423
            +A +E  QQ+   + A+E ++  L  A  +   ++QQ   LE   LE+ + L   +   +
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIK---LEQQVDDLEGS-LEQEKKLRMDLERAK 1058

Query: 424  RTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFEL-----------KKLKEEW 472
            R    D   A++ +  +E E   L E   + E  + N Q ++           KK+KE  
Sbjct: 1059 RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQ 1118

Query: 473  SQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLRE-------KTEVLLQKE 525
            ++ E     + + +E  R  R + ++Q ++L+  ++E  + L E       + E+  ++E
Sbjct: 1119 ARIE----ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1174

Query: 526  QEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQ-EDLLRLRGPLQAEA---- 580
             E  ++ R    A L   Q +A    LR   A+  A + EQ ++L R++  L+ E     
Sbjct: 1175 AEFQKMRRDLEEATL---QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1231

Query: 581  -----LSVNESHVTS---------RAMQDPVFQLPTAGRTPNGEVGAMDLT----QLQKE 622
                 L+ N   V+          R ++D + +L +        +   DLT    +LQ E
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN--DLTAQRGRLQTE 1289

Query: 623  KQDLEQQLLEKNKTIKQMQ-------QRMLELRKTLQKELKIR 658
              +  +QL EK   + Q+        Q++ EL++ L++E+K +
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 144/730 (19%), Positives = 294/730 (40%), Gaps = 107/730 (14%)

Query: 5    LKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRN 64
            L +++ E +   +  GGAT     ++K+  A                 R DL    L+  
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEF------------QKMRRDLEEATLQHE 1192

Query: 65   EQIRKLEARLSD----YAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKM 120
                 L  + +D      EQ+ NLQ++K+KLE      ++ S  K +  +          
Sbjct: 1193 ATAATLRKKHADSVAELGEQIDNLQRVKQKLE------KEKSEMKMEIDDLASNVETVSK 1246

Query: 121  AEGLALALARKDQEWSEKMDQLEKEK----NILTAQLQEMKNQSMNLFQRRDEMDEL--- 173
            A+G    + R  ++   ++   E+E+    N LTAQ   ++ +S    ++ DE + L   
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306

Query: 174  -----EGFQQQELSKIKHML---LKKEESLG---------------KMEQELEART---R 207
                 + F QQ + ++K  L   +K + +L                + E+E E++    R
Sbjct: 1307 LSRGKQAFTQQ-IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365

Query: 208  ELSRTQEELMN-SNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQ 266
             LS+   E+     +  +D  Q+ EEL+     L ++            +K  +LE+ +Q
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQ 1425

Query: 267  ELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTL 326
             LQ  ++ L +D+++  A           L +K  + +K L +    ++  +E   E   
Sbjct: 1426 RLQNEVEDLMLDVERTNA-------ACAALDKKQRNFDKILAE---WKQKCEETHAELEA 1475

Query: 327  AEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQE 386
            +++       +L   +++  ++++ LET  RE +   Q   +  +Q    +A    +I E
Sbjct: 1476 SQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ----IAEGGKRIHE 1531

Query: 387  LAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAA 446
            L    ++   V+Q+   L+    E   +LE +   + R +        +  R++ +++  
Sbjct: 1532 LEKIKKQ---VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1588

Query: 447  LKECRNEYERSLQNHQFEL--------------KKLKEEWSQREI-VSVAMAQALEEVRK 491
            + + +  + R +++ Q  L              KK++ + ++ EI ++ A   A E +R 
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1648

Query: 492  QREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEA 551
             R        N   I+ + + +L +        ++++  +ER  N    +I +L+A LE 
Sbjct: 1649 YR--------NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700

Query: 552  L---RTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRA--MQDPVFQLPTAGRT 606
                R +  +E    +E+  LL  +           E+ ++     M+D + +   A   
Sbjct: 1701 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEK 1760

Query: 607  PNGEV--GAMDLTQLQKEKQD---LEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDN 661
                +   AM   +L+KE+     LE+      +T+K +Q R+ E  +   K  K +   
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQK 1820

Query: 662  ELFEVREKPG 671
                VRE  G
Sbjct: 1821 LEARVRELEG 1830



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 98/532 (18%), Positives = 217/532 (40%), Gaps = 102/532 (19%)

Query: 65   EQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGL 124
            ++  +  A L    ++ R+L     K++ A E+  D  +   + +N+  Q   + + E +
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ-LETLKRENKNLQQEISDLTEQI 1522

Query: 125  ALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQ-----------SMNLFQRRDEMDEL 173
            A    ++  E  +   Q+E+EK  L A L+E +              + L Q + E+D  
Sbjct: 1523 AEG-GKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1581

Query: 174  EGFQQQELSKIKHMLLKKEESL-GKMEQELEARTR----------ELSRTQEELMNSNQM 222
               + +E+ ++K   ++  ES+   ++ E+ +R            +L+  + +L ++N+M
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1641

Query: 223  SSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKV 282
            +++  +     Q      +   D  + S+   + ++  +E++   LQA I++L   L++ 
Sbjct: 1642 AAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT 1701

Query: 283  TAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAAR 342
                                                   + + +AEQ L D  +++    
Sbjct: 1702 E--------------------------------------RSRKIAEQELLDASERVQLLH 1723

Query: 343  SSQAKAINT---LETRVR----ELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESS 395
            +     INT   LET +     E+E  LQ +    +++K  +       +EL      S+
Sbjct: 1724 TQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783

Query: 396  HVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYE 455
            H+++    +EQ   +    L+           A+Q   + G +Q+++  A ++E   E E
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLD----------EAEQLALKGGKKQIQKLEARVRELEGEVE 1833

Query: 456  RSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLR 515
               + +   +K L++             + ++E+  Q EE ++    L  ++D+ +  ++
Sbjct: 1834 SEQKRNAEAVKGLRKH-----------ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882

Query: 516  EKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQE 567
                     +++  + E   N+ L +  +LQ ELE     +AEE A +AE +
Sbjct: 1883 -------SYKRQAEEAEEQSNTNLAKFRKLQHELE-----EAEERADIAESQ 1922


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  117 bits (294), Expect = 3e-26
 Identities = 161/751 (21%), Positives = 316/751 (42%), Gaps = 91/751 (12%)

Query: 6    KKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSRED----LSSQLL 61
            K+K A E  V         +  +++K +              D     ED    L+    
Sbjct: 970  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKT 1029

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSM---RKFQEQNETFQANRA 118
            +  +Q+  LE  L    +   +L++ K KLE  L+  Q+S+M      Q+ NE  +    
Sbjct: 1030 KLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEF 1089

Query: 119  KMA---------EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
            +M+         + LA+ L +K +E   ++++LE+E     A   + + Q  +L +  +E
Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149

Query: 170  MDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS-SDLSQ 228
            + E         S    M  K+E    KM ++LE  T +   T   L   +  S ++L +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209

Query: 229  KLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQE 288
            +++ LQR    LE+++  +        S +  + + +   + + + L   L ++  + +E
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269

Query: 289  KEDVITHLQEKVASLE-------KRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQL--- 338
            ++ +I  L  + A L        ++L++    +  V +L + K    Q +E+ ++QL   
Sbjct: 1270 QQRLINELSAQKARLHTESGEFSRQLDEK---DAMVSQLSRGKQAFTQQIEELKRQLEEE 1326

Query: 339  LAARSSQAKAINTLE---TRVRELEQTLQASEEQLQQ----SKGIVAAQETQIQELAAAN 391
              A+S+ A A+ +       +RE  +  Q ++ +LQ+    +   VA   T+ +  A   
Sbjct: 1327 TKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQR 1386

Query: 392  QESSHVQQQALALE-QQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAA---- 446
             E     ++ LA   Q   E  +A+ ++  +LE+T+   Q   E  M  +E+ NAA    
Sbjct: 1387 TEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIAL 1446

Query: 447  ----------LKECRNEYERS---LQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQR 493
                      L E + +YE +   L+  Q E + L  E  + +         LE ++++ 
Sbjct: 1447 DKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKREN 1506

Query: 494  EEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQ-----LQAE 548
            +  QQ+ ++LT  I E  +++ E  +V  Q + E  +L+     A   +       L+ +
Sbjct: 1507 KNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQ 1566

Query: 549  LEALRTLKAEEAAVVAEQEDLL------------RLRGPLQAEALSVNESHVTSRAMQDP 596
            LE L  +K+E    +AE+++ L             ++  L AE  S N++    + M+  
Sbjct: 1567 LE-LNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625

Query: 597  VFQLPT-----------AGRTPNGEVGAMDLTQLQKE-----KQDLEQQLLEKNKTIKQM 640
            + ++             A R      G +  TQL  +     + DL++QL    +    M
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLM 1685

Query: 641  QQRMLELRKTLQKELKIR--PDNELFEVREK 669
            Q  + ELR +L++  + R   + EL +  E+
Sbjct: 1686 QAEVEELRASLERTERGRKMAEQELLDASER 1716



 Score =  105 bits (263), Expect = 1e-22
 Identities = 134/598 (22%), Positives = 255/598 (42%), Gaps = 45/598 (7%)

Query: 76   DYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEW 135
            + A      +K KE+L     K ++   +      E         AE  ALA A      
Sbjct: 852  EMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE----- 906

Query: 136  SEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESL 195
             E+ DQL K K  L A+++E+  ++ +  +   E+   +   + E S++K  +   E +L
Sbjct: 907  -ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965

Query: 196  GKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQR-HYSTLEEQRDHVIASKTGA 254
             K+E+E  A   ++    EE+   ++  + L+++ + LQ  H  TL++ +       T  
Sbjct: 966  AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLT 1025

Query: 255  ESKITALEQKEQELQALIQQ---LSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNL 311
            ++K T LEQ+  +L+  ++Q   L +DL++     ++ E  +   QE     E   +Q  
Sbjct: 1026 KAK-TKLEQQVDDLEGSLEQEKKLCMDLERAK---RKLEGDLKLAQESTMDTENDKQQ-- 1079

Query: 312  SGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQ 371
                 + E LK+K     NL+   +   A      K I  L+ R+ ELE+ ++A      
Sbjct: 1080 -----LNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRA 1134

Query: 372  QSKGIVAAQETQIQELAAANQESSHVQQQALAL----EQQFLERTQALEAQIVALERTRA 427
            +++   +    +++E++   +E+       + +    E +F +  + LE   +  E T A
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAA 1194

Query: 428  ADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMA---- 483
            A +      + +L ++  +L+  + + E+     + E+  L    S  E VS A A    
Sbjct: 1195 ALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLA---SNMETVSKAKANFEK 1251

Query: 484  ------QALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNS 537
                    L E++ + EE Q+    L+A          E +  L +K+  + QL RG  +
Sbjct: 1252 MCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQA 1311

Query: 538  ALLQIHQLQAELEALRTLKAEEA-AVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDP 596
               QI +L+ +LE     K+  A A+ + + D   LR   + E  +  E           
Sbjct: 1312 FTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSE 1371

Query: 597  VFQLPTAGRTPNGEVGAMDLT-QLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
            V Q  T       E  A+  T +L++ K+ L Q+L +  + ++ +  +   L KT Q+
Sbjct: 1372 VAQWRT-----KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQR 1424



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 145/724 (20%), Positives = 305/724 (42%), Gaps = 114/724 (15%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQ-DSSMRK 105
            ++ +   E+++++L  +    RKLE   S+  + + +L+    K+E   EKH  ++ ++ 
Sbjct: 927  TERAEDEEEINAELTAKK---RKLEDECSELKKDIDDLELTLAKVE--KEKHATENKVKN 981

Query: 106  FQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQ 165
              E+        AK+ +    AL    Q+  + +   E + N LT    +++ Q      
Sbjct: 982  LTEEMAGLDETIAKLTKEKK-ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQ------ 1034

Query: 166  RRDEMDELEGFQQQE------LSKIKHML-----------LKKEESLGKMEQELEARTRE 208
                +D+LEG  +QE      L + K  L           +  E    ++ ++L+ +  E
Sbjct: 1035 ----VDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFE 1090

Query: 209  LSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQEL 268
            +S  Q ++ +   ++  L +K++ELQ     LEE+ +   AS+  AE + + L ++ +E+
Sbjct: 1091 MSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1150

Query: 269  QALIQQLS--------------IDLQKVTAETQEK----EDVITHLQEKVASLEKRLEQN 310
               +++                 + QK+  + +E     E     L++K A     L + 
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQ 1210

Query: 311  LSGEEHV-QELLKEKTLAEQNLEDTRQQLLAARSSQA---KAINTLETRVRELE------ 360
            +   + V Q+L KEK+  +  + D    +     ++A   K   TLE ++ E++      
Sbjct: 1211 IDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQ 1270

Query: 361  ----QTLQASEEQLQQSKGIVAAQ----ETQIQELAAANQESSHVQQQALALEQQFLERT 412
                  L A + +L    G  + Q    +  + +L+   Q  +   QQ   L++Q  E T
Sbjct: 1271 QRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFT---QQIEELKRQLEEET 1327

Query: 413  QALEAQIVALERTR----------AADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQ 462
            +A      AL+  R            +Q    +  R + + N+ + + R +YE       
Sbjct: 1328 KAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT 1387

Query: 463  FELKKLKEEWSQR----EIVSVAMAQALEEVRKQREEFQQQAANL----------TAIID 508
             EL++ K++ +QR    E    A+      + K ++  Q +  +L             +D
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALD 1447

Query: 509  EKEQNLREKTEVLLQKEQEI-LQLE------RGHNSALLQIHQLQAE-LEALRTLKAEEA 560
            +K++N  +      QK +E   +LE      R  ++ L ++     E L+ L TLK E  
Sbjct: 1448 KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENK 1507

Query: 561  AVVAEQEDLLRL-----RGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMD 615
             +  E  DL        +   + E +     H  S  +Q  + +   +     G++  + 
Sbjct: 1508 NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSE-LQTSLEEAEASLEHEEGKILRIQ 1566

Query: 616  LTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKEL--KIRPDNELFEVREKPGPE 673
            L +L + K ++++++ EK++ + Q+++  L + +++Q  L  +IR  N+   +++K   +
Sbjct: 1567 L-ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625

Query: 674  MANM 677
            +  M
Sbjct: 1626 LNEM 1629



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 107/520 (20%), Positives = 215/520 (41%), Gaps = 81/520 (15%)

Query: 188  LLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHV 247
            LLK  E+    E+E+     E  +T+EEL  +     +L +K+  L      ++E+ D  
Sbjct: 843  LLKSAET----EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTL------MQEKNDLQ 892

Query: 248  IASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLE--- 304
            +  +  A++   A E+ +Q ++  IQ L   +++VT   +++E++   L  K   LE   
Sbjct: 893  LQVQAEADALADAEERCDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951

Query: 305  ----------------------------KRLEQNLSG-EEHVQELLKEKTLAEQNLEDTR 335
                                        K L + ++G +E + +L KEK    + L++  
Sbjct: 952  SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK----KALQEAH 1007

Query: 336  QQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESS 395
            QQ L     +   +NTL     +LEQ +   E  L+Q K +    E   ++L    + + 
Sbjct: 1008 QQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQ 1067

Query: 396  HVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYE 455
                     +QQ  E+ +  E ++  L+     +Q  A Q  +++++  A ++E   E E
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIE 1127

Query: 456  ------RSLQNHQFELKKLKEEWSQR-EIVSVAMAQALEEVRKQREEFQQQAANLTAIID 508
                     +  + +L +  EE S+R E    A +  +E  +K+  EFQ+          
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR-------- 1179

Query: 509  EKEQNLREKTEVLLQKEQEILQLERGHNSALLQI-HQLQAELEALRTLKAEEAAVVAEQE 567
                  R+  E  LQ E     L + H  ++ ++  Q+ +     + L+ E++ +  E  
Sbjct: 1180 ------RDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIN 1233

Query: 568  DLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDL--TQLQKEKQD 625
            D   L   ++  + +        R ++D + ++ T        +  +     +L  E  +
Sbjct: 1234 D---LASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGE 1290

Query: 626  LEQQLLEKNKTIKQMQ-------QRMLELRKTLQKELKIR 658
              +QL EK+  + Q+        Q++ EL++ L++E K +
Sbjct: 1291 FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAK 1330



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 123/599 (20%), Positives = 253/599 (42%), Gaps = 76/599 (12%)

Query: 4    KLKKKIAEETAVAQRPGGATRIPR--------SVSKESVASMGADSGDDFA-SDGSSSRE 54
            +LK+++ EET        A +  R           +E  A      G   A S+ +  R 
Sbjct: 1318 ELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT 1377

Query: 55   DLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQ 114
               +  ++R E++ + + +L+      + LQ  +E +E    K       K + QNE   
Sbjct: 1378 KYETDAIQRTEELEEAKKKLA------QRLQDAEEHVEAVNSKCASLEKTKQRLQNEVED 1431

Query: 115  AN-RAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDEL 173
                 + +    +AL +K + + + + + +++     A+L+  + +S +L          
Sbjct: 1432 LMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSL---------- 1481

Query: 174  EGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEEL 233
                  EL K+K+     EESL      LE   RE    Q+E+ +  +  ++  + + EL
Sbjct: 1482 ----STELFKVKNAY---EESL----DHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL 1530

Query: 234  QRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVI 293
            ++    L+ ++  +  S   AE+ +   E K   +Q  + Q+  ++ +  AE  E+ D +
Sbjct: 1531 EKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQL 1590

Query: 294  --THLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINT 351
               HL+  V S++  L+  +       + L+ K   E +L +   QL  A    A+A+  
Sbjct: 1591 KRNHLR-VVESMQSTLDAEIRSR---NDALRIKKKMEGDLNEMEIQLNHANRQAAEALRN 1646

Query: 352  LETRVRELEQT----------LQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQA 401
            L      L+ T              +EQL   +      + +++EL A+ + +   ++ A
Sbjct: 1647 LRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMA 1706

Query: 402  LALEQQFL---ERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSL 458
               EQ+ L   ER Q L  Q  +L  T+   +T   Q   ++E     ++E RN  E++ 
Sbjct: 1707 ---EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED---IVQEARNAEEKAK 1760

Query: 459  Q------NHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQ 512
            +          ELKK ++  +  E +   M Q +++++ + +E +Q      A+   K+Q
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ-----LALKGGKKQ 1815

Query: 513  NLREKTEVLLQKEQEILQLERGHN-SALLQIHQLQAELEALRTLKAEEAAVVAEQEDLL 570
               +K E  +++ +  ++ E+ HN  A+  + + +  ++ L     E+   +   +DL+
Sbjct: 1816 --IQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV 1872



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 73/356 (20%), Positives = 155/356 (43%), Gaps = 55/356 (15%)

Query: 51   SSREDLSSQLLRRNEQIR---KLEARLSDY-----------AEQVRNLQKIKEKLEIALE 96
            S +  L +++  RN+ +R   K+E  L++            AE +RNL+  +  L+   +
Sbjct: 1600 SMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT-Q 1658

Query: 97   KHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEK-----EKNILTA 151
             H D ++R   +  E     +  M E  A  +  + +E    +++ E+     E+ +L A
Sbjct: 1659 LHLDDAIRGQDDLKE-----QLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDA 1713

Query: 152  --QLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTREL 209
              ++Q +  Q+ +L   + +++      Q E+  I       EE   K   +      EL
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEEL 1773

Query: 210  SRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQ 269
             + Q+   +  +M  ++ Q +++LQ      E+     +A K G + +I  LE + +EL+
Sbjct: 1774 KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ-----LALK-GGKKQIQKLEARVRELE 1827

Query: 270  ALI---QQLSID-----------LQKVTAETQEKEDVITHLQEKVASLEKRLE----QNL 311
            + +   Q+ +++           ++++T +T+E    I  LQ+ V  L+ +++    Q  
Sbjct: 1828 SEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAE 1887

Query: 312  SGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASE 367
              EE     L +    +  LE+ +++   A S     +N L  + RE+   + + E
Sbjct: 1888 EAEEQSNVNLAKFRKLQHELEEAKERADIAESQ----VNKLRVKSREVHTKVISEE 1939


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score =  117 bits (293), Expect = 4e-26
 Identities = 152/705 (21%), Positives = 317/705 (44%), Gaps = 85/705 (12%)

Query: 50  SSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSM------ 103
           + SR+ LS +L     +IR+L   L +  EQ+ + ++  E++EI L++ Q  +M      
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302

Query: 104 ---RKFQEQNETFQANRAKMAEGLALALARKDQE------WSEKMDQLEKEKNILTAQLQ 154
              R ++++ +  +  +A   + L   ++R  +       +  ++++L+++  +L     
Sbjct: 303 RSARMYRDELDALR-EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361

Query: 155 EMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELE----------- 203
            +++Q      R D++ ELE    Q  +K+  M ++++    K+E+ +E           
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421

Query: 204 ---------------ARTRELSRTQEELMNS--NQMSSDLSQKLE-ELQRHYSTLEEQRD 245
                          +RT ELS   ++ +    N+++S    KLE E Q    T+EE R 
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481

Query: 246 HVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEK 305
             + S  G  SKI  +E++ Q L   ++ L  ++ +     Q  +++   L ++ A LEK
Sbjct: 482 -TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540

Query: 306 RLEQ-NLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQ 364
            +E    + E  ++ L +E     Q +   RQ+      SQ  A    E RV+++E+  +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQR------SQISA----EARVKDIEKENK 590

Query: 365 ASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQF--LERTQALEAQIVAL 422
              E ++++   ++  E + +++    +      ++A  LE +   LE+   L  + +  
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650

Query: 423 ERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAM 482
            +         EQ   +LE+EN  LK+  +    S +N  F+L+ L++E SQ +  ++ +
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLESLEKENSQLDEENLEL 706

Query: 483 AQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQI 542
            + +E ++    +  Q       +  EKEQ L++  E+L    ++  +LE  +    ++ 
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQ-LKKGLELLKASFKKTERLEVSYQGLDIEN 765

Query: 543 HQLQAELE----ALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVF 598
            +LQ  LE     ++ L++E   +  E + L +    L+  +  + +    +++++    
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825

Query: 599 QLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLEL---RKTLQKEL 655
           QL              D  QL+KE + L QQ   K+ T+++   ++  L    KTL KE+
Sbjct: 826 QL------------EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873

Query: 656 KIRPDNEL-FEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLK 699
            I  ++ +  +  EK   E+   A ++   T +T   ++  E LK
Sbjct: 874 GIYKESCVRLKELEKENKELVKRA-TIDIKTLVTLREDLVSEKLK 917



 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 132/605 (21%), Positives = 263/605 (43%), Gaps = 52/605 (8%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETF 113
            E  +S+L R N +++K      +   Q+ +L+K   +L        D    + +   E+ 
Sbjct: 662  EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL--------DEENLELRRNVESL 713

Query: 114  QANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDEL 173
            +    KMA+   L L  K+ E SEK +QL+K   +L A  ++ +   ++ +Q  D     
Sbjct: 714  KCASMKMAQ---LQLENKELE-SEK-EQLKKGLELLKASFKKTERLEVS-YQGLD----- 762

Query: 174  EGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEEL 233
               + Q L K      KK + L    Q+LE   + L +  EEL  S       S++LE+L
Sbjct: 763  --IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-------SKRLEQL 813

Query: 234  QRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVI 293
            ++   +LE++   +   K   E +   L Q+ +     +++ ++ +  +  E +     I
Sbjct: 814  EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873

Query: 294  THLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLE 353
               +E    L++  ++N       +EL+K  T+  + L   R+ L++ +    +  N LE
Sbjct: 874  GIYKESCVRLKELEKEN-------KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926

Query: 354  TRVRELEQTLQASEEQLQQSKGIVAAQETQIQ-ELAAANQESSHVQQQALALEQQFLERT 412
                ELE+     E  L   +    ++   ++ +L +  ++S  ++++ +A  +  LE +
Sbjct: 927  KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 986

Query: 413  ----QALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKL 468
                Q L  ++  +++   A      Q   ++ Q +  +    N++ER  Q    EL K+
Sbjct: 987  TNYNQQLRQELKTVKKNYEA--LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKV 1044

Query: 469  KEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTA-IIDEKEQNLR-EKTEVLLQKEQ 526
            K+   + E  +  +    + ++ Q ++ + Q  NL A I+  + Q +  ++    LQ + 
Sbjct: 1045 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1104

Query: 527  EILQLERGH-NSALLQIHQLQAELEALR-TLKAEEAAVVAEQEDLLRLRGPLQAEALSVN 584
              LQ+E    NS    +    A+L   + +L+ E  +V+ E+EDL  L   L  +   + 
Sbjct: 1105 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1164

Query: 585  ESHVTSRAMQDPVFQ----LPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQM 640
              H    +  + +      L +A +  N EV   DL     +    + QL +  K +K  
Sbjct: 1165 LLHERQASEYESLISKHGTLKSAHK--NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE 1222

Query: 641  QQRML 645
            Q++ML
Sbjct: 1223 QEKML 1227



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 132/641 (20%), Positives = 251/641 (39%), Gaps = 127/641 (19%)

Query: 132 DQEWSEKMDQLEKE-----KNI------LTAQLQEMKNQSMNLFQRRDEMDELEGFQQQE 180
           D +W E  D  +++     KN+      L  +  E     + L + RD +  L       
Sbjct: 172 DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSA 231

Query: 181 LSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTL 240
            S      +K+ ES   +  EL     ++ R ++EL    +   D  Q+LE+++     L
Sbjct: 232 QSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRL 291

Query: 241 EEQRDHVIASKTGA---ESKITALEQKEQELQALIQQLS------IDLQKVTAETQEKED 291
           +++  ++++    A     ++ AL +K   +  L  ++S       D++   A  +E ++
Sbjct: 292 QQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351

Query: 292 VITHLQEKVASLEKRLEQNLSGEEHVQELLKE----------------------KTLAEQ 329
               L E    LE +LE   +  + + EL KE                      + L E+
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411

Query: 330 N--LEDTRQQLL---------------------AARSSQAKAINTL-ETRVRELE---QT 362
           N  LE  ++Q +                     A + S    +N L  +R+ +LE   Q+
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQS 471

Query: 363 LQASEEQLQQSKGIVAAQETQIQELAAANQESS---HVQQQALALEQQFLERTQAL---- 415
           L  + E+L+ +   V    ++I ++   NQ  S    + +  +  E+Q L+  Q L    
Sbjct: 472 LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531

Query: 416 ------------------EAQIVALER-----------TRAADQTTAEQGMRQLEQENAA 446
                             E QI  LE+            R   Q +AE  ++ +E+EN  
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591

Query: 447 LKECRNEYERSLQNHQFELKKLKEE---WSQREIVSVAMAQALEEVRKQREEFQQQAANL 503
           L E   E    L   +FE +++K+E   + ++   +  +   L  + K+ E  Q++  NL
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651

Query: 504 TAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVV 563
                       EK E L Q+  E+ +  R     L     L  +LE   +L+ E + + 
Sbjct: 652 KITC--------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLE---SLEKENSQLD 700

Query: 564 AEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEK 623
            E  +L R    L+  ++ + +  + ++ ++    QL              +  ++  + 
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 624 QDLEQQLLEK-----NKTIKQMQQRMLEL---RKTLQKELK 656
            D+E Q L+K     NK I+Q++  + +L    +TLQK L+
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801



 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 108/519 (20%), Positives = 217/519 (41%), Gaps = 51/519 (9%)

Query: 53   REDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNET 112
            REDL S+ L+  +    LE       +    L+KI    E  L   Q +        +  
Sbjct: 908  REDLVSEKLKTQQMNNDLE-------KLTHELEKIGLNKERLLHDEQSTD-------DSR 953

Query: 113  FQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDE 172
            ++   +K+   L  +L  K+++ +    +LE+  N      QE+K    N    +   DE
Sbjct: 954  YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013

Query: 173  LEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEE 232
                Q           +  E++  K E+E +  TREL + ++ L+   + ++ L  + + 
Sbjct: 1014 ERMVQSSPP-------ISGEDN--KWERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1064

Query: 233  LQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDV 292
            L+     LE Q +++ A     + +  +L+++   LQ    +L ++   + +++    + 
Sbjct: 1065 LKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1124

Query: 293  ITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTL 352
               L  + +SLE   E  +   E ++ L        + LE   ++  +   S      TL
Sbjct: 1125 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184

Query: 353  ETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERT 412
            ++  + LE   +  E++  Q    +  Q+ Q+++L    ++   V+Q+ + LE +  E T
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQ----LLKQKGQLEDL----EKMLKVEQEKMLLENKNHE-T 1235

Query: 413  QALEAQIVALERTR---AADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLK 469
             A E + +  E  R      Q   E  + Q + +N  LK   N  +      + E  KLK
Sbjct: 1236 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN--LKSLLNNSKLEQTRLEAEFSKLK 1293

Query: 470  EEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEIL 529
            E++ Q +I S        ++  Q E   Q   NL    +E+ ++L ++ + L+ + + +L
Sbjct: 1294 EQYQQLDITST-------KLNNQCELLSQLKGNL----EEENRHLLDQIQTLMLQNRTLL 1342

Query: 530  QLERGHNSALLQIHQLQ--AELEALRTLKAEEAAVVAEQ 566
            + +   +  L  + Q Q   +L  LR  K +    + +Q
Sbjct: 1343 E-QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 83/407 (20%), Positives = 171/407 (42%), Gaps = 40/407 (9%)

Query: 273 QQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEK-------- 324
           Q+   DLQ +      +ED+   L+     L++ +++     E + EL +E+        
Sbjct: 167 QENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPH 226

Query: 325 --TLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQET 382
             + A+        +   +R   +  +   + ++R L Q L+   EQL   K  +   E 
Sbjct: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEI 286

Query: 383 QIQELAAANQ------ESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQG 436
           +++ L   N        S+ + +  L   ++   R   LE++ V+  + R  D    +  
Sbjct: 287 ELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESE-VSRYKERLHDIEFYKAR 345

Query: 437 MRQLEQENAALKECRNEYERSLQN---HQFELKKLKEEWSQREIVSVAMAQALEEVRKQR 493
           + +L+++N  L E +   E  L+       +L +L++E  Q +     M    +  RK+ 
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405

Query: 494 EEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALR 553
           EE  ++  N+T  + +K Q++ E   +  + EQ     E          H++  EL + R
Sbjct: 406 EELMEE--NMTLEMAQK-QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN-ELTSSR 461

Query: 554 TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGA 613
            LK E      E + L +       E L      V   A +  + ++    +  + +V  
Sbjct: 462 LLKLE-----MENQSLTK-----TVEELRTTVDSVEGNASK--ILKMEKENQRLSKKVEI 509

Query: 614 MDLTQLQKEKQDLEQ-QLLEKN--KTIKQMQQRMLELRKTLQKELKI 657
           ++  ++ +EKQ L+  Q L K+  K   Q+++ +  LR+  ++++KI
Sbjct: 510 LE-NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 555


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score =  117 bits (293), Expect = 4e-26
 Identities = 152/705 (21%), Positives = 317/705 (44%), Gaps = 85/705 (12%)

Query: 50  SSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSM------ 103
           + SR+ LS +L     +IR+L   L +  EQ+ + ++  E++EI L++ Q  +M      
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302

Query: 104 ---RKFQEQNETFQANRAKMAEGLALALARKDQE------WSEKMDQLEKEKNILTAQLQ 154
              R ++++ +  +  +A   + L   ++R  +       +  ++++L+++  +L     
Sbjct: 303 RSARMYRDELDALR-EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361

Query: 155 EMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELE----------- 203
            +++Q      R D++ ELE    Q  +K+  M ++++    K+E+ +E           
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421

Query: 204 ---------------ARTRELSRTQEELMNS--NQMSSDLSQKLE-ELQRHYSTLEEQRD 245
                          +RT ELS   ++ +    N+++S    KLE E Q    T+EE R 
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481

Query: 246 HVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEK 305
             + S  G  SKI  +E++ Q L   ++ L  ++ +     Q  +++   L ++ A LEK
Sbjct: 482 -TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540

Query: 306 RLEQ-NLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQ 364
            +E    + E  ++ L +E     Q +   RQ+      SQ  A    E RV+++E+  +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQR------SQISA----EARVKDIEKENK 590

Query: 365 ASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQF--LERTQALEAQIVAL 422
              E ++++   ++  E + +++    +      ++A  LE +   LE+   L  + +  
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650

Query: 423 ERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAM 482
            +         EQ   +LE+EN  LK+  +    S +N  F+L+ L++E SQ +  ++ +
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLESLEKENSQLDEENLEL 706

Query: 483 AQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQI 542
            + +E ++    +  Q       +  EKEQ L++  E+L    ++  +LE  +    ++ 
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQ-LKKGLELLKASFKKTERLEVSYQGLDIEN 765

Query: 543 HQLQAELE----ALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVF 598
            +LQ  LE     ++ L++E   +  E + L +    L+  +  + +    +++++    
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825

Query: 599 QLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLEL---RKTLQKEL 655
           QL              D  QL+KE + L QQ   K+ T+++   ++  L    KTL KE+
Sbjct: 826 QL------------EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873

Query: 656 KIRPDNEL-FEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLK 699
            I  ++ +  +  EK   E+   A ++   T +T   ++  E LK
Sbjct: 874 GIYKESCVRLKELEKENKELVKRA-TIDIKTLVTLREDLVSEKLK 917



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 132/604 (21%), Positives = 260/604 (43%), Gaps = 51/604 (8%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETF 113
            E  +S+L R N +++K      +   Q+ +L+K   +L        D    + +   E+ 
Sbjct: 662  EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL--------DEENLELRRNVESL 713

Query: 114  QANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDEL 173
            +    KMA+   L L  K+ E SEK +QL+K   +L A  ++ +   ++ +Q  D     
Sbjct: 714  KCASMKMAQ---LQLENKELE-SEK-EQLKKGLELLKASFKKTERLEVS-YQGLD----- 762

Query: 174  EGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEEL 233
               + Q L K      KK + L    Q+LE   + L +  EEL  S       S++LE+L
Sbjct: 763  --IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-------SKRLEQL 813

Query: 234  QRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVI 293
            ++   +LE++   +   K   E +   L Q+ +     +++ ++ +  +  E +     I
Sbjct: 814  EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873

Query: 294  THLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLE 353
               +E    L++  ++N       +EL+K  T+  + L   R+ L++ +    +  N LE
Sbjct: 874  GIYKESCVRLKELEKEN-------KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926

Query: 354  TRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERT- 412
                ELE+     E  L   +      +    +L +  ++S  ++++ +A  +  LE + 
Sbjct: 927  KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEEST 986

Query: 413  ---QALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLK 469
               Q L  ++  +++   A      Q   ++ Q +  +    N++ER  Q    EL K+K
Sbjct: 987  NYNQQLRQELKTVKKNYEA--LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044

Query: 470  EEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTA-IIDEKEQNLR-EKTEVLLQKEQE 527
            +   + E  +  +    + ++ Q ++ + Q  NL A I+  + Q +  ++    LQ +  
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104

Query: 528  ILQLERGH-NSALLQIHQLQAELEALR-TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNE 585
             LQ+E    NS    +    A+L   + +L+ E  +V+ E+EDL  L   L  +   +  
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL 1164

Query: 586  SHVTSRAMQDPVFQ----LPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQ 641
             H    +  + +      L +A +  N EV   DL     +    + QL +  K +K  Q
Sbjct: 1165 LHERQASEYESLISKHGTLKSAHK--NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQ 1222

Query: 642  QRML 645
            ++ML
Sbjct: 1223 EKML 1226



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 132/641 (20%), Positives = 251/641 (39%), Gaps = 127/641 (19%)

Query: 132 DQEWSEKMDQLEKE-----KNI------LTAQLQEMKNQSMNLFQRRDEMDELEGFQQQE 180
           D +W E  D  +++     KN+      L  +  E     + L + RD +  L       
Sbjct: 172 DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSA 231

Query: 181 LSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTL 240
            S      +K+ ES   +  EL     ++ R ++EL    +   D  Q+LE+++     L
Sbjct: 232 QSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRL 291

Query: 241 EEQRDHVIASKTGA---ESKITALEQKEQELQALIQQLS------IDLQKVTAETQEKED 291
           +++  ++++    A     ++ AL +K   +  L  ++S       D++   A  +E ++
Sbjct: 292 QQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351

Query: 292 VITHLQEKVASLEKRLEQNLSGEEHVQELLKE----------------------KTLAEQ 329
               L E    LE +LE   +  + + EL KE                      + L E+
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411

Query: 330 N--LEDTRQQLL---------------------AARSSQAKAINTL-ETRVRELE---QT 362
           N  LE  ++Q +                     A + S    +N L  +R+ +LE   Q+
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQS 471

Query: 363 LQASEEQLQQSKGIVAAQETQIQELAAANQESS---HVQQQALALEQQFLERTQAL---- 415
           L  + E+L+ +   V    ++I ++   NQ  S    + +  +  E+Q L+  Q L    
Sbjct: 472 LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531

Query: 416 ------------------EAQIVALER-----------TRAADQTTAEQGMRQLEQENAA 446
                             E QI  LE+            R   Q +AE  ++ +E+EN  
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591

Query: 447 LKECRNEYERSLQNHQFELKKLKEE---WSQREIVSVAMAQALEEVRKQREEFQQQAANL 503
           L E   E    L   +FE +++K+E   + ++   +  +   L  + K+ E  Q++  NL
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651

Query: 504 TAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVV 563
                       EK E L Q+  E+ +  R     L     L  +LE   +L+ E + + 
Sbjct: 652 KITC--------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLE---SLEKENSQLD 700

Query: 564 AEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEK 623
            E  +L R    L+  ++ + +  + ++ ++    QL              +  ++  + 
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 624 QDLEQQLLEK-----NKTIKQMQQRMLEL---RKTLQKELK 656
            D+E Q L+K     NK I+Q++  + +L    +TLQK L+
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 110/521 (21%), Positives = 223/521 (42%), Gaps = 56/521 (10%)

Query: 53   REDLSSQLLRRNEQIRKLEARLSDYAEQVRN-LQKIKEKLE-IALEKHQDSSMRKFQEQN 110
            REDL S+ L+                +Q+ N L+K+  +LE I L K +   +   Q  +
Sbjct: 908  REDLVSEKLK---------------TQQMNNDLEKLTHELEKIGLNKER--LLHDEQSTD 950

Query: 111  ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEM 170
            + ++   +K+   L  +L  K+++ +    +LE+  N      QE+K    N    +   
Sbjct: 951  DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1010

Query: 171  DELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKL 230
            DE    Q           +  E++  K E+E +  TREL + ++ L+   + ++ L  + 
Sbjct: 1011 DEERMVQSSPP-------ISGEDN--KWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061

Query: 231  EELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKE 290
            + L+     LE Q +++ A     + +  +L+++   LQ    +L ++   + +++    
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121

Query: 291  DVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAIN 350
            +    L  + +SLE   E  +   E ++ L        + LE   ++  +   S      
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181

Query: 351  TLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLE 410
            TL++  + LE   +  E++  Q    +  Q+ Q+++L    ++   V+Q+ + LE +  E
Sbjct: 1182 TLKSAHKNLEVEHRDLEDRYNQ----LLKQKGQLEDL----EKMLKVEQEKMLLENKNHE 1233

Query: 411  RTQALEAQIVALERTR---AADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKK 467
             T A E + +  E  R      Q   E  + Q + +N  LK   N  +      + E  K
Sbjct: 1234 -TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN--LKSLLNNSKLEQTRLEAEFSK 1290

Query: 468  LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQE 527
            LKE++ Q +I S        ++  Q E   Q   NL    +E+ ++L ++ + L+ + + 
Sbjct: 1291 LKEQYQQLDITST-------KLNNQCELLSQLKGNL----EEENRHLLDQIQTLMLQNRT 1339

Query: 528  ILQLERGHNSALLQIHQLQ--AELEALRTLKAEEAAVVAEQ 566
            +L+ +   +  L  + Q Q   +L  LR  K +    + +Q
Sbjct: 1340 LLE-QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 83/407 (20%), Positives = 171/407 (42%), Gaps = 40/407 (9%)

Query: 273 QQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEK-------- 324
           Q+   DLQ +      +ED+   L+     L++ +++     E + EL +E+        
Sbjct: 167 QENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPH 226

Query: 325 --TLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQET 382
             + A+        +   +R   +  +   + ++R L Q L+   EQL   K  +   E 
Sbjct: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEI 286

Query: 383 QIQELAAANQ------ESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQG 436
           +++ L   N        S+ + +  L   ++   R   LE++ V+  + R  D    +  
Sbjct: 287 ELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESE-VSRYKERLHDIEFYKAR 345

Query: 437 MRQLEQENAALKECRNEYERSLQN---HQFELKKLKEEWSQREIVSVAMAQALEEVRKQR 493
           + +L+++N  L E +   E  L+       +L +L++E  Q +     M    +  RK+ 
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405

Query: 494 EEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALR 553
           EE  ++  N+T  + +K Q++ E   +  + EQ     E          H++  EL + R
Sbjct: 406 EELMEE--NMTLEMAQK-QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN-ELTSSR 461

Query: 554 TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGA 613
            LK E      E + L +       E L      V   A +  + ++    +  + +V  
Sbjct: 462 LLKLE-----MENQSLTK-----TVEELRTTVDSVEGNASK--ILKMEKENQRLSKKVEI 509

Query: 614 MDLTQLQKEKQDLEQ-QLLEKN--KTIKQMQQRMLELRKTLQKELKI 657
           ++  ++ +EKQ L+  Q L K+  K   Q+++ +  LR+  ++++KI
Sbjct: 510 LE-NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 555


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  117 bits (293), Expect = 4e-26
 Identities = 130/618 (21%), Positives = 253/618 (40%), Gaps = 59/618 (9%)

Query: 65   EQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGL 124
            E+ ++L + ++D    + NL + KE+LE A + H      +         A+       L
Sbjct: 459  EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQV--------ASLTSELTTL 510

Query: 125  ALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKI 184
               + ++DQE +    Q ++++  L   LQ+ +  S  L   R ++++L    +Q+  ++
Sbjct: 511  NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGL---RHQVEQLSSSLKQKEQQL 567

Query: 185  KHMLLKKEESLGKMEQEL----EARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTL 240
            K +  K+E +     Q+L    E R   L      L     +  + + KLE LQ+     
Sbjct: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627

Query: 241  EEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKV 300
             E RD    S T A+ +   L +K +ELQA ++    +  +  A+  E E  +   Q+K 
Sbjct: 628  NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687

Query: 301  ASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELE 360
               E+  ++    +E +Q L +   + + +LE+ +++   A   Q + I+ L+   R L 
Sbjct: 688  TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747

Query: 361  QTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIV 420
            +  +   ++L++ +      E ++Q+L  A+Q  + V ++ LA            EA   
Sbjct: 748  EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA------------EAM-- 793

Query: 421  ALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSV 480
                   A Q TAE    QL +E AA +E    YE S Q          EE     +   
Sbjct: 794  -------AAQHTAESECEQLVKEVAAWRE---RYEDSQQ----------EEAQYGAMFQE 833

Query: 481  AMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALL 540
             +    EE  K R+E Q+    +  I    E  +  +   L +    + +  +      +
Sbjct: 834  QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV 893

Query: 541  QIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQL 600
            +  +L  +L  L+   A  +  VA  E L+R  G  Q  A             + P +  
Sbjct: 894  RAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLE 953

Query: 601  PTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPD 660
               GR              Q   Q +E++  +    +++++  ++E +   Q+E + + +
Sbjct: 954  EQQGR---------QFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE-RGQQE 1003

Query: 661  NELFEVREKPGPEMANMA 678
             E+  + ++ G   A++A
Sbjct: 1004 REVARLTQERGRAQADLA 1021



 Score =  106 bits (265), Expect = 7e-23
 Identities = 146/618 (23%), Positives = 264/618 (42%), Gaps = 86/618 (13%)

Query: 22  ATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQV 81
           A R  R +  + VAS  + SG++F S   +S   +   L     Q+R+L+ +L+D     
Sbjct: 175 AKREIRFLELQKVAS--SSSGNNFLSGSPAS--PMGDILQTPQFQMRRLKKQLADERSNR 230

Query: 82  RNLQ-KIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKD-QEWSEKM 139
             L+ ++ E  ++  EK  D+ +   Q++ +       K A   A  L  K+ +E  +K 
Sbjct: 231 DELELELAENRKLLTEK--DAQIAMMQQRIDRLALLNEKQA---ASPLEPKELEELRDKN 285

Query: 140 DQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKME 199
           + L    +    Q Q++K +   + ++ +++ E  G    +L +    L + +++L ++ 
Sbjct: 286 ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELT 345

Query: 200 QELEARTRE----LSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQ----RDHVIASK 251
           +E    T+E     ++ ++EL  + Q    L +K E LQ   S LEE     +D+    K
Sbjct: 346 EEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEK 405

Query: 252 TGAESKITALEQKEQE----------LQALIQQLSIDLQKVTA-----------ETQEKE 290
                 +  LE  +QE          LQA ++ L  +  +  A           E Q+  
Sbjct: 406 GEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLS 465

Query: 291 DVITHLQEKVASLEKRLEQ-NLSGEEH-------VQELLKEKTLAEQNLEDTRQQLLAAR 342
            +IT LQ  +++L +  E+   + + H       V  L  E T     ++   Q+L   +
Sbjct: 466 SLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK 525

Query: 343 SSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQ--ESSHVQQQ 400
               +    L   +++ EQ  Q    Q++Q    +  +E Q++E+A   +     H QQ 
Sbjct: 526 QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQL 585

Query: 401 ALALEQQ---FLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERS 457
           A A E++     ER  AL+ Q+ ALE+ +AA        +  L+Q+     E R+  + S
Sbjct: 586 ATAAEEREASLRERDAALK-QLEALEKEKAAK-------LEILQQQLQVANEARDSAQTS 637

Query: 458 LQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREK 517
           +   Q E  +L  +  +       +   +E  R+++ E Q Q A L   +  ++Q   EK
Sbjct: 638 VTQAQREKAELSRKVEE-------LQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690

Query: 518 TEVLLQKEQEILQLERGHNSALLQIHQLQAELEALR----TLKAEEAAVVAEQEDLLRLR 573
             V  +K+Q  LQ             QLQA  E+L+    +L+ E+       E+  R  
Sbjct: 691 ERVAQEKDQ--LQ------------EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI 736

Query: 574 GPLQAEALSVNESHVTSR 591
             L+AE  S+ E H   R
Sbjct: 737 SELKAETRSLVEQHKRER 754



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 133/647 (20%), Positives = 276/647 (42%), Gaps = 67/647 (10%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEK--HQDSSMRKFQEQNE 111
            E    Q   R +Q R++ ARL+         ++ + + ++ALEK    +  MR     NE
Sbjct: 990  ESQGQQQEERGQQEREV-ARLTQ--------ERGRAQADLALEKAARAELEMRLQNALNE 1040

Query: 112  TFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMD 171
              +   A + E LA AL  K+     K  +L K + +  AQ++E++     + Q ++++ 
Sbjct: 1041 Q-RVEFATLQEALAHALTEKEG----KDQELAKLRGLEAAQIKELEELRQTVKQLKEQLA 1095

Query: 172  ELE-------GFQQQELSKIKHMLLKKEE---SLGKMEQELEARTRELSRTQEELMNSNQ 221
            + E       G Q +   + +    K E     + K+EQ+ + +  +    +  L     
Sbjct: 1096 KKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERA 1155

Query: 222  MSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQK 281
              ++    LE LQ       ++  H  ++   A+ ++ A   K Q+      +    + +
Sbjct: 1156 SRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR 1215

Query: 282  VTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAA 341
               E + K  +I+ L+E+V+ L +++ +     + ++ L+  ++   Q LE+  + L A 
Sbjct: 1216 GRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAE 1275

Query: 342  RSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQA 401
             +S +       + +RE  Q+L+   E+ +       A E   QEL +  + +  + Q+ 
Sbjct: 1276 TASNSARAAERSSALREEVQSLREEAEKQR------VASENLRQELTSQAERAEELGQEL 1329

Query: 402  LALEQQFLERTQALEAQIVALERTRA--ADQTTAEQGMRQLEQENAAL-KECRNEYERSL 458
             A +++F ++ QAL    +    T+A  ++   A+   +QL+ E AA  K  R E E+S 
Sbjct: 1330 KAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK 1389

Query: 459  Q---NHQFELKKLKEEWSQREIVSVAMAQ---ALEEVRKQREEFQQQAANLT---AIIDE 509
            Q     + EL + + E  +   +   +A+     +++R ++  + +Q + L     ++ E
Sbjct: 1390 QAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAE 1449

Query: 510  KEQNLREKTEVLLQ---------KEQEILQLERGHNSALLQIHQLQAELEA----LRTLK 556
            + + L E+  +  Q         +E+ + +L      A  ++ ++Q E ++    L  + 
Sbjct: 1450 ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMT 1509

Query: 557  AE-EAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQL-------PTAGRTPN 608
            A+ E A V   E+  R +   Q     V +  V  R     V +L         A +   
Sbjct: 1510 AKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQ 1569

Query: 609  GEVGAMDLT--QLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
             ++ A+     + Q+E Q L+ QL E    + Q +Q     +  ++K
Sbjct: 1570 QKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEK 1616



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 130/578 (22%), Positives = 246/578 (42%), Gaps = 76/578 (13%)

Query: 56   LSSQLLRRNEQI----RKLEARLSDYAEQVRNLQKIKEKLEIALEK--HQDSSMRKFQEQ 109
            L  Q  ++ EQ     R LEA  +  AE+   L+ ++ +LE   ++  H  S++   Q +
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191

Query: 110  NETFQA---NRAKMAEGLALALARKDQEWSEK---MDQLEKEKNILTAQLQEMKNQSMNL 163
               F+    + +K  +     +AR  QE   K   +  LE+E +IL  Q+ E + +S  L
Sbjct: 1192 LAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251

Query: 164  FQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS 223
              +R  M E E  Q+ E  +++ +  +   +  +  +   A   E+   +EE       S
Sbjct: 1252 --KRLVMAESEKSQKLE-ERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS 1308

Query: 224  SDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL-------- 275
             +L Q+L         L ++           E  ++ L+ +    QAL+ +L        
Sbjct: 1309 ENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ 1368

Query: 276  SIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLK-EKTLAEQNLEDT 334
             +  ++  AE + +E++    Q K A+   R E  L  +  + EL+   + +AEQ  E T
Sbjct: 1369 QLQAEQAAAEKRHREELE---QSKQAAGGLRAEL-LRAQRELGELIPLRQKVAEQ--ERT 1422

Query: 335  RQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVA-----AQETQIQELAA 389
             QQL A ++S A+ ++ L+     L +  +   E+    +  +      A+E  +QELAA
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482

Query: 390  ANQES----SHVQQQA---------------------LALEQQFLERTQALEAQIVALE- 423
               ++    + VQ++A                     L   Q+F E  Q L AQ+  LE 
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEV 1542

Query: 424  ----RTRAADQTT-----AEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQ 474
                +T+  ++ +     ++Q  +  +Q+  A++    E ++  Q  Q +L +L+ + SQ
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ 1602

Query: 475  REIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQ---EILQL 531
            +E  +      +E+ +   +  +QQ   L   +   EQ  +E  E+  + E+   E+ Q 
Sbjct: 1603 KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA 1662

Query: 532  ERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDL 569
                  A      L A+   +R+L+A+ A    +  DL
Sbjct: 1663 GLKTKEAEQTCRHLTAQ---VRSLEAQVAHADQQLRDL 1697



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 74/311 (23%), Positives = 130/311 (41%), Gaps = 26/311 (8%)

Query: 56   LSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQA 115
            L  ++  +    ++L A  + YAEQ+  L+K    L  A E            Q    + 
Sbjct: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLL--AEENRGLGERANLGRQFLEVEL 1469

Query: 116  NRAKMAEGLALALARKDQEWSEKMDQLE-----KEKNILTAQLQEMKNQSMNLFQRRDE- 169
            ++A+      LA  R D E      Q E     +E  ++TA+ +  K + +   QR  E 
Sbjct: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529

Query: 170  -------MDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQM 222
                   +++LE FQ+++  +++ +  K  +S    +Q  + + ++L   Q +   S Q 
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADS----DQASKVQQQKLKAVQAQGGESQQE 1585

Query: 223  SSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKV 282
            +  L  +L ELQ   S  E+  +H       A++   A +Q+ QELQ  ++ L   LQK 
Sbjct: 1586 AQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE-QLQKE 1644

Query: 283  TAETQEKEDVITHLQEKVASLEKRLEQNLSG-EEHVQELLKEKTLAEQNLED-----TRQ 336
              E + + + + H  ++     K  EQ        V+ L  +   A+Q L D        
Sbjct: 1645 NKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVAT 1704

Query: 337  QLLAARSSQAK 347
              L +R  QAK
Sbjct: 1705 DALKSREPQAK 1715



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 106/445 (23%), Positives = 186/445 (41%), Gaps = 59/445 (13%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDY-AEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNET 112
            ++L   ++  +E+ +KLE RL    AE   N  +  E+     E+ Q  S+R+  E+   
Sbjct: 1249 KELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ--SLREEAEKQRV 1306

Query: 113  FQAN-------RAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSM--NL 163
               N       +A+ AE L   L    + W EK  Q  KE+ + T QL+    Q++   L
Sbjct: 1307 ASENLRQELTSQAERAEELGQEL----KAWQEKFFQ--KEQALSTLQLEHTSTQALVSEL 1360

Query: 164  FQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELS-------RTQEEL 216
               +    +L+  Q     + +  L + +++ G +  EL    REL        +  E+ 
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420

Query: 217  MNSNQMSSDLSQKLEEL----QRHYSTLEEQRDHVIASKTGAESKITALEQKE----QEL 268
              + Q+ ++ +   E+L    + H    EE R     +  G +     L+Q      QEL
Sbjct: 1421 RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL 1480

Query: 269  QALIQQLSIDLQKVTAETQEKE---DVITHLQE--KVASLEKRLE-----QNLSGE---- 314
             A+       L +V  E Q      +V+T   E  KV  LE+R       Q L+ +    
Sbjct: 1481 AAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540

Query: 315  --------EHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQAS 366
                    + V+EL K+   ++Q  +  +Q+L A ++   ++    +    +L + LQA 
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNE-LQAQ 1599

Query: 367  EEQLQQSKGIVAAQ-ETQIQELAAANQESSHVQQQALALEQQFLERTQ-ALEAQIVALER 424
              Q +Q+      Q E       A  Q++  +Q+Q  +LEQ   E  +   EA+ +  E 
Sbjct: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659

Query: 425  TRAADQT-TAEQGMRQLEQENAALK 448
             +A  +T  AEQ  R L  +  +L+
Sbjct: 1660 QQAGLKTKEAEQTCRHLTAQVRSLE 1684



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 103/471 (21%), Positives = 188/471 (39%), Gaps = 55/471 (11%)

Query: 231 EELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKE 290
           E L    S L++ R H  +S     S    LE  E EL  +   L       +   ++ E
Sbjct: 59  ERLDFVCSFLQKNRKHP-SSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWE 117

Query: 291 DVITHLQEKVASLEKRL---EQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAK 347
                +Q ++A + K +   E  L+  E ++  L +K         T  + L+  S QAK
Sbjct: 118 QFEYKIQAELAVILKFVLDHEDGLNLNEDLENFL-QKAPVPSTCSSTFPEELSPPSHQAK 176

Query: 348 AINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQ 407
                E R  EL++   +S      S    +     +Q            Q Q   L++Q
Sbjct: 177 R----EIRFLELQKVASSSSGNNFLSGSPASPMGDILQT----------PQFQMRRLKKQ 222

Query: 408 FL-ERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELK 466
              ER+   E ++   E  +   +  A+  M Q   +  AL    NE + +      E K
Sbjct: 223 LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL---NEKQAA---SPLEPK 276

Query: 467 KLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQ---NLREKTEVLLQ 523
           +L+E   + E +++ + + L++ +  + E  Q    +  + +E       LRE    L Q
Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336

Query: 524 KEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSV 583
            +  + +L   H+ A  +  + QA+LE   +   ++   + E+ ++L+ +       LS 
Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGK-------LSQ 389

Query: 584 NESHVTSRAMQDPVFQLPTAGRTPNGEVGAM--DLTQLQKEKQDLEQQLLEKNKTIKQMQ 641
            E H++   +QD           P  E G +  D+ QL+  KQ  E   L  N T  Q +
Sbjct: 390 LEEHLSQ--LQD----------NPPQEKGEVLGDVLQLETLKQ--EAATLAANNTQLQAR 435

Query: 642 QRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDARE 692
             MLE  +  Q+   +       E +++    + ++  S++N   L+ A+E
Sbjct: 436 VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN---LSQAKE 483


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score =  117 bits (293), Expect = 4e-26
 Identities = 153/675 (22%), Positives = 304/675 (45%), Gaps = 80/675 (11%)

Query: 34  VASMGADSGDDFASDGSSS-REDLSSQLLRRNEQIRKLEARLSDYAEQ-----------V 81
           + S  ADS     S  SS  ++ L+ +L     ++R++   L D  EQ           V
Sbjct: 229 IKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLV 288

Query: 82  RNLQKIK-EKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQE------ 134
             LQK+K E +++A +     S R ++++ ++ +  +A   E L L L R  ++      
Sbjct: 289 LELQKVKQENIQLAADAR---SARAYRDELDSLR-EKANRVERLELELTRCKEKLHDVDF 344

Query: 135 WSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRR-DEMDELEGFQQQELSKIKHMLLKKEE 193
           +  +M++L +E NI+  + + M  + +   + R D++ ELE    Q  SK+  + L ++ 
Sbjct: 345 YKARMEEL-REDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDT 403

Query: 194 SLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQR-DHVIASKT 252
              ++E+ LE     L   Q++ MN    S+ L  +LE+L ++    +  R   V     
Sbjct: 404 DKKRIEELLE-ENMVLEIAQKQSMNE---SAHLGWELEQLSKNADLSDASRKSFVFELNE 459

Query: 253 GAESKITALEQKEQELQALIQQL---SIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQ 309
            A S+I  LE++ Q LQ+ IQ L   S+ L++   +  E E     L +K+  L+ +LE+
Sbjct: 460 CASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLER 519

Query: 310 NLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAIN------------------- 350
                + ++ L +E    ++ L+   + L A ++ Q K +                    
Sbjct: 520 EKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQV 579

Query: 351 TLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALE---QQ 407
           + E R++++E+  +A  + + ++ G ++  E + ++L    +++    ++A  LE   Q+
Sbjct: 580 SSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQR 639

Query: 408 FLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKK 467
             E    L  ++ +LE T        E   + L+ EN  L++  +    +LQN   +L+ 
Sbjct: 640 LQEENGRLARKVTSLE-TATEKVEALEHESQGLQLENRTLRKSLD----TLQNVSLQLEG 694

Query: 468 LKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQE 527
           L+ +  Q +  ++ + + +E +R    +  Q       +  EKE+ LR+  ++L    ++
Sbjct: 695 LERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEE-LRKNVDLLKALGKK 753

Query: 528 ILQLERGHNSALLQIHQLQAELEA----LRTLKAEEAAVVAEQEDLLRLRGPLQAEALSV 583
             +LE  + S   +  +LQ  LE+     +TL++E   + AE++ L R    L+     +
Sbjct: 754 SERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQL 813

Query: 584 NESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQR 643
             +    +A++  V QL              D   L+KE + L QQ+  K+  +     +
Sbjct: 814 EGAEKDRKALEQEVAQL------------EKDKKLLEKEAKRLWQQVELKDAVLDDSTAK 861

Query: 644 MLELRK---TLQKEL 655
           +  + K    L KEL
Sbjct: 862 LSAVEKESRALDKEL 876



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 133/645 (20%), Positives = 266/645 (41%), Gaps = 70/645 (10%)

Query: 58   SQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIA----------LEKHQDSSMRKFQ 107
            +Q+ R N+Q+ + +  L    + ++ L K  E+LE++          L++  +SS  K Q
Sbjct: 724  AQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQ 783

Query: 108  ----EQNETFQANRAKMAEGLALALARKDQEWSEK--------MDQLEKEKNILTAQLQE 155
                E  E     +A   +  AL LA    E +EK        + QLEK+K +L  + + 
Sbjct: 784  TLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKR 843

Query: 156  MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQ----------ELEAR 205
            +  Q        D+        ++E   +   L +  ++ GK+++          ++   
Sbjct: 844  LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVH 903

Query: 206  TRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVI-ASKTGAESKITALE-Q 263
             R L+  +E+L+     S  LS +L++L +    +   R+ ++    +G+++K   LE +
Sbjct: 904  ARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGR 963

Query: 264  KEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKR---LEQNLSGEEHVQEL 320
             E  L+  +      +  + A+ +EK  +   L+ ++  L+K    L QN    +H+Q  
Sbjct: 964  NESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNS 1023

Query: 321  LKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQ 380
             K            ++            +  ++ R  ELE+   A + + Q  K  +   
Sbjct: 1024 FKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHL 1083

Query: 381  ETQ----IQELAAANQESSHVQQQALALEQQ----------FLERTQALEAQIVALERTR 426
            ETQ      ++    ++S+ +Q+    L+ Q             ++ AL AQ   L+   
Sbjct: 1084 ETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHH 1143

Query: 427  AADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQAL 486
             A +T  E   RQ EQ  AA       YE  LQ+H+  L  L E  S      +     L
Sbjct: 1144 TAKETENESLQRQQEQLTAA-------YEALLQDHE-HLGTLHERQSAEYEALIRQHSCL 1195

Query: 487  EEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQ 546
            + + +  E   ++       + +++  L E+ +VL  + + + Q +R +  A+ +  +L+
Sbjct: 1196 KTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLR 1255

Query: 547  AELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRT 606
             EL+ +  L  +   +  E E+L      L+    S+N + +     Q    +L    +T
Sbjct: 1256 GELDRVNFLHHQ---LKGEYEELHAHTKELKT---SLNNAQLELNRWQARFDELKEQHQT 1309

Query: 607  PNGEVGAMD-----LTQLQKEKQDLEQQLLEKNKTIKQMQQRMLE 646
             +  +  +D     L++L+   ++    LL + + + Q  Q +LE
Sbjct: 1310 MDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLE 1354



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 163/741 (21%), Positives = 303/741 (40%), Gaps = 135/741 (18%)

Query: 54   EDLSSQLLRRNEQIRK-LEARLSDYAEQVRNLQKIKEKLEIAL----EKHQDSS---MRK 105
            E LS +L+R  EQ++  +E   +D A Q+++L++ K+ L  A+    E+ Q SS   M+ 
Sbjct: 528  ETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKD 587

Query: 106  FQEQNETF-----QAN----------------------RAKMAEGLALALARKDQE---- 134
             +++N+       +AN                      + + AE L   L R  +E    
Sbjct: 588  VEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL 647

Query: 135  ---------WSEKMDQLEKEKN-------ILTAQLQEMKNQSMNLFQRRDEMDELEGFQQ 178
                      +EK++ LE E          L   L  ++N S+ L     +  +L+  + 
Sbjct: 648  ARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDA-EN 706

Query: 179  QELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYS 238
             EL ++   +      L +ME+E     ++L R +EEL  +  +   L +K E L+  Y 
Sbjct: 707  LELRRLVETMRFTSTKLAQMERE----NQQLEREKEELRKNVDLLKALGKKSERLELSYQ 762

Query: 239  TLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKV---TAETQEKEDVITH 295
            ++  +   +  S   +  K   LE +  EL+A  Q L  DL+ +    A+ +  E     
Sbjct: 763  SVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA 822

Query: 296  LQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETR 355
            L+++VA LEK  ++ L  E+  + L ++  L +  L+D+  + L+A   +++A++    R
Sbjct: 823  LEQEVAQLEK--DKKLL-EKEAKRLWQQVELKDAVLDDSTAK-LSAVEKESRALDKELAR 878

Query: 356  VRELEQTLQASEEQLQ--------QSKGIVAAQETQIQELAAANQESSHVQQQALALEQQ 407
             R+    L+  E+  +         ++ +   +E  + E   + Q SS + + +  LE+ 
Sbjct: 879  CRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKV 938

Query: 408  FLERTQAL-------EAQIVALE-RTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQ 459
             L R   L       + +   LE R  +A +TT       +++E   L E + E + SL 
Sbjct: 939  GLNRELLLQEDDSGSDTKYKILEGRNESALKTTL-----AMKEEKIVLLEAQMEEKASLN 993

Query: 460  NH-QFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKE---QNLR 515
               + EL+ LK+E          + Q   E +  +  F+  A    A    KE      +
Sbjct: 994  RQLESELQMLKKECE-------TLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHK 1046

Query: 516  EKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALR-----------TLKAEEAAVVA 564
            E T  LL+ +   ++LER + +   +   L+ +L+ L            TL+ + A +  
Sbjct: 1047 EATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQE 1106

Query: 565  EQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQ 624
                L      LQ E  +++       A    +    TA  T N          LQ++++
Sbjct: 1107 HNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETEN--------ESLQRQQE 1158

Query: 625  DLE---QQLLEKNKTIKQMQQRML----------ELRKTLQKELKIRPDNELFEVREKPG 671
             L    + LL+ ++ +  + +R               KTL + L++    E  E+ E+ G
Sbjct: 1159 QLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLEL----EHKELGERHG 1214

Query: 672  PEMANMAPSVTNNTDLTDARE 692
              +   A        LT  RE
Sbjct: 1215 DMLKRKAELEEREKVLTTERE 1235



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 105/528 (19%), Positives = 212/528 (40%), Gaps = 61/528 (11%)

Query: 53   REDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKF---QEQ 109
            REDL  + L+  +   +L+ +LS      + L+K+    E+ L++    S  K+   + +
Sbjct: 911  REDLVLEKLKSQQLSSELD-KLS------QELEKVGLNRELLLQEDDSGSDTKYKILEGR 963

Query: 110  NETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
            NE+       M E   + L  + +E +    QLE E  +L  + + ++            
Sbjct: 964  NESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQN---------- 1013

Query: 170  MDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQK 229
                +G  Q   +  KH   K   S     Q  EA          EL+     + +L + 
Sbjct: 1014 ----QGEGQHLQNSFKHPAGKTAAS----HQGKEAWGPGHKEATMELLRVKDRAIELERN 1065

Query: 230  LEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEK 289
               LQ     L+EQ  H+        S+I  L    Q+  A +Q+ +  LQ  TA+ Q +
Sbjct: 1066 NAALQAEKQLLKEQLQHLETQNVTFSSQILTL----QKQSAFLQEHNTTLQTQTAKLQVE 1121

Query: 290  EDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEK----TLAEQNLEDTRQQ---LLAAR 342
               ++     + +    L+ + + +E   E L+ +    T A + L    +    L   +
Sbjct: 1122 NSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQ 1181

Query: 343  SSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQAL 402
            S++ +A+    + ++ L + L+   ++L +  G +  ++ +++E           +++ L
Sbjct: 1182 SAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEE-----------REKVL 1230

Query: 403  ALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQ 462
              E++ L++ Q   A  +   +    +         QL+ E   L     E + SL N Q
Sbjct: 1231 TTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQ 1290

Query: 463  FELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLL 522
             EL + +  + + +     M  +L ++    E   +   NL    +E+  +L  + ++L 
Sbjct: 1291 LELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNL----EEENHHLLSQIQLLS 1346

Query: 523  QKEQEILQLERGHNSALLQIHQLQAE----LEALRTLKAEEAAVVAEQ 566
            Q+ Q +L+    +     Q H+ Q +    L ALR  K +    + +Q
Sbjct: 1347 QQNQMLLEQNMENKE---QYHEEQKQYIDKLNALRRHKEKLEEKIMDQ 1391


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  117 bits (292), Expect = 5e-26
 Identities = 166/768 (21%), Positives = 335/768 (43%), Gaps = 111/768 (14%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKI------KEKLEIALEKHQD 100
            ++  ++++DL S+ + +  +++ L ++L+D     + L++        E+  +  E+   
Sbjct: 509  AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQ 568

Query: 101  SSMRKFQEQNETFQA-------------NRAKMAEGLALALARKDQEWSEKMDQLEKEKN 147
              ++   EQNE  +A             + + +AE L   +A KD++  +  D L  E++
Sbjct: 569  MQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD 628

Query: 148  ILTAQLQEMKN-QSMNLFQRRDEMDELEGFQQQ------ELSKIKHMLLKKEESLGKMEQ 200
             LT++ +E+K+ Q+MN F  + E+ +L+    +      EL K++  +  K++ +  +E+
Sbjct: 629  RLTSKEEELKDIQNMN-FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE 687

Query: 201  ELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYS-----TLEEQRDHVIASKTG-- 253
            +L+    E+S   EE    N  +  L  ++++LQ   S      + EQ +  I  K    
Sbjct: 688  QLQ---HEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL 744

Query: 254  ------AESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRL 307
                   E+ +  +  KE+EL A+  + S  L K   + + K++        V  L+K +
Sbjct: 745  KTVEELLETGLIQVATKEEELNAIRTENS-SLTKEVQDLKAKQNDQVSFASLVEELKKVI 803

Query: 308  EQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLE----------TRVR 357
             +     + V+ELL+ + L   N E T Q L     +  + I  ++          ++V+
Sbjct: 804  HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ 863

Query: 358  ELEQTLQASEEQLQQSKGIVAAQETQ-------IQELAAANQE-SSHVQQQALALEQQFL 409
            EL+  L+  EEQ+   K ++  +E         +Q+L   N+   +HVQ+ A    ++  
Sbjct: 864  ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923

Query: 410  ERTQALEAQIV------------ALERTRAADQTTAEQGMRQLEQEN-------AALKEC 450
              +Q  E +IV            A+ + R +D ++  Q ++ ++ EN         LK+ 
Sbjct: 924  SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 983

Query: 451  RNEYERSLQNHQFELKKLKEEWSQREIVSV-----AMAQALEEVRKQREEFQQQAANLTA 505
              +   S   H+  LK + E   ++EI  +     ++  A+E  RK+  + +++      
Sbjct: 984  NYQQASSFPPHEELLKVISER--EKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAME 1041

Query: 506  IIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAE 565
             +   E+ L++K     ++ Q+  Q+E     A   + +L  ++     L   E     E
Sbjct: 1042 ALASTEKMLQDKVNKTSKERQQ--QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE 1099

Query: 566  QEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQD 625
            ++    + G   +E + V E  +        + QL          V A     LQK ++ 
Sbjct: 1100 KKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC---EKYKSVLAETEGILQKLQRS 1156

Query: 626  LEQQ-------LLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFE--VREKPGPEMAN 676
            +EQ+       + E +KTIKQMQ       + L+   ++R +N+  E   RE+   EM  
Sbjct: 1157 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE---RLRSENKDIENLRREREHLEMEL 1213

Query: 677  MAPSVTNNTDLTDAREINFEYLKHVVLKF-----MSCRESEAFHLIKA 719
                +  +T +T+ RE+  + L  +  K       + R++E  +L+KA
Sbjct: 1214 EKAEMERSTYVTEVRELK-DLLTELQKKLDDSYSEAVRQNEELNLLKA 1260



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 126/637 (19%), Positives = 275/637 (43%), Gaps = 54/637 (8%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQE----Q 109
            E +   +  ++E+++ +E  L     QV      KE+   A+     S  ++ Q+    Q
Sbjct: 731  EQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAIRTENSSLTKEVQDLKAKQ 786

Query: 110  NETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
            N+  Q + A + E L   +  KD +     + LE E   +  + + +++    +   ++E
Sbjct: 787  ND--QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEE 844

Query: 170  MDELEGFQQQELS------KIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS 223
            +  ++  + Q+LS      +++++L  KEE +  M+  LE + ++L+ T + L       
Sbjct: 845  IGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ------ 898

Query: 224  SDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQE---LQALIQQLSIDLQ 280
             DL ++ E L+ H   + +      +S +  E     L++KE E   L+A++++   DL 
Sbjct: 899  -DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 957

Query: 281  KVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA 340
              T   Q+ +D     + ++  L+++  Q  S     +ELLK  +  E+ +     +L +
Sbjct: 958  SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 1017

Query: 341  ARSS---QAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHV 397
             + +   Q K  N L  +  E  + L AS E++ Q K    ++E Q Q++ A   E+  V
Sbjct: 1018 LKDAVEHQRKKNNDLREKNWEAMEAL-ASTEKMLQDKVNKTSKERQ-QQVEAVELEAKEV 1075

Query: 398  QQQ-----ALALEQQFLERTQALE--AQIVALERTRAADQTTAEQGMRQLEQENAALKEC 450
             ++     ++     + E     E  A+      + + +    E  +++ ++ +  L+  
Sbjct: 1076 LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLE 1135

Query: 451  RNEYERSLQNHQFELKKLKEEWSQREIV-SVAMAQALEEVRKQREEFQQQAANLTAIIDE 509
              +Y+  L   +  L+KL+    Q E    V + ++ + +++ +  F      L  +  E
Sbjct: 1136 CEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE 1195

Query: 510  KE--QNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAEL-EALRTLKAEEAAVVAEQ 566
             +  +NLR + E L   E E+ + E   ++ + ++ +L+  L E  + L    +  V + 
Sbjct: 1196 NKDIENLRREREHL---EMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1252

Query: 567  EDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEV--GAMDLTQLQK--- 621
            E+L  L+  L      +       + +   + +   +      ++   A D T ++    
Sbjct: 1253 EELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDV 1312

Query: 622  ----EKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKE 654
                E  + E   +  N+T+ Q+QQ +  + + L KE
Sbjct: 1313 SPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1349



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 132/667 (19%), Positives = 270/667 (40%), Gaps = 77/667 (11%)

Query: 41  SGDDFASDGSSSRED--LSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKH 98
           +G+   SD  S   D  LS  L   ++Q+  +   + + +  VR  +K ++K +  LE+ 
Sbjct: 69  NGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQ 128

Query: 99  --QDSSMRKFQEQN-ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQE 155
             ++S   K   +  E     +       A A  +K  +   K    +++K + T  +  
Sbjct: 129 VIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPS 188

Query: 156 MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEE 215
            + +++ L Q   E  +  G  +++ S  K    +K E++   E  + A T         
Sbjct: 189 KRQEALPLHQ---ETKQESGSGKKKASSKK----QKTENVFVDEPLIHATT------YIP 235

Query: 216 LMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL 275
           LM+ N  SS +  K E +      L+  +   I  K+G +   T  +++  E++   +  
Sbjct: 236 LMD-NADSSPVVDKREVID----LLKPDQVEGI-QKSGTKKLKTETDKENAEVK--FKDF 287

Query: 276 SIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGE-----EHVQELLKEKTLAEQN 330
            + L+ +     E   V+  L+EK   ++  L+++  GE       +QE  K+K LA   
Sbjct: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQE--KDKLLAAVK 345

Query: 331 -----LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQ 385
                 +D  +QL     ++ +  N + TR+++   TL+  E  + Q+K  V+ QETQ  
Sbjct: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE-KEHNVFQNKIHVSYQETQQM 404

Query: 386 ELA------AANQESSHVQQQ------ALALEQQFLERTQALEAQIVALERTRAADQTT- 432
           ++           E +H++Q+      A++     LE  Q+ E   +  +  R  ++ T 
Sbjct: 405 QMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTE 464

Query: 433 --------------AEQGMR----QLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQ 474
                         AEQ       QL++     +E ++   +    H+   + L+ ++  
Sbjct: 465 KTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVA 524

Query: 475 REIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERG 534
           +E    ++   L +    +++ +Q+   L     E EQ    K E L  + Q+IL+    
Sbjct: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLM----ESEQKRVNKEESLQMQVQDILEQNEA 580

Query: 535 HNSALLQIHQLQAELEALRTLKAEEAAVVAEQE-DLLRLRGPLQAEALSVNESHVTSRAM 593
             + + Q H   A   +   L  E   V+AE++  + +    L +E   +       + +
Sbjct: 581 LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDI 640

Query: 594 QDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
           Q+  F L         +  A +      E + ++Q +  K+  I+ +++++        +
Sbjct: 641 QNMNFLL--KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698

Query: 654 ELKIRPD 660
           E KI  D
Sbjct: 699 EFKILND 705



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 79/363 (21%), Positives = 151/363 (41%), Gaps = 49/363 (13%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQK----IKEKLEIALEKH-------QDSS 102
            E+L   +  R ++I  L   L    + V + +K    ++EK   A+E         QD  
Sbjct: 995  EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1054

Query: 103  MRKFQEQNETFQANRAKMAEGLALALARKDQ-------EWSEKMDQLEKEKNILTAQLQE 155
             +  +E+ +  +A   +  E L     +          EW    ++  KE    T+  +E
Sbjct: 1055 NKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1114

Query: 156  MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELS-RTQE 214
            +K     L  +  E DE+    Q E  K K +L + E  L K+++ +E    +   +  E
Sbjct: 1115 VKV----LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDE 1170

Query: 215  ELMNSNQMSSDLSQKLEELQRHYS------TLEEQRDHVIASKTGAESKITALEQKEQEL 268
                  QM S  +   +EL+R  S       L  +R+H+      AE + +    + +EL
Sbjct: 1171 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL 1230

Query: 269  QALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAE 328
            + L+ +L   L    +E   + + +  L+   A L + L +  + +   Q++  +   A+
Sbjct: 1231 KDLLTELQKKLDDSYSEAVRQNEELNLLK---AQLNETLTKLRTEQNERQKVAGDLHKAQ 1287

Query: 329  QNLEDTRQQLLAA----------------RSSQAKAIN-TLETRVRELEQTLQASEEQLQ 371
            Q+LE  + +++ A                 SS+ + ++ +L   V +L+Q LQA  +QL 
Sbjct: 1288 QSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLT 1347

Query: 372  QSK 374
            + K
Sbjct: 1348 KEK 1350


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  117 bits (292), Expect = 5e-26
 Identities = 166/768 (21%), Positives = 335/768 (43%), Gaps = 111/768 (14%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKI------KEKLEIALEKHQD 100
            ++  ++++DL S+ + +  +++ L ++L+D     + L++        E+  +  E+   
Sbjct: 509  AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQ 568

Query: 101  SSMRKFQEQNETFQA-------------NRAKMAEGLALALARKDQEWSEKMDQLEKEKN 147
              ++   EQNE  +A             + + +AE L   +A KD++  +  D L  E++
Sbjct: 569  MQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD 628

Query: 148  ILTAQLQEMKN-QSMNLFQRRDEMDELEGFQQQ------ELSKIKHMLLKKEESLGKMEQ 200
             LT++ +E+K+ Q+MN F  + E+ +L+    +      EL K++  +  K++ +  +E+
Sbjct: 629  RLTSKEEELKDIQNMN-FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE 687

Query: 201  ELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYS-----TLEEQRDHVIASKTG-- 253
            +L+    E+S   EE    N  +  L  ++++LQ   S      + EQ +  I  K    
Sbjct: 688  QLQ---HEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL 744

Query: 254  ------AESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRL 307
                   E+ +  +  KE+EL A+  + S  L K   + + K++        V  L+K +
Sbjct: 745  KTVEELLETGLIQVATKEEELNAIRTENS-SLTKEVQDLKAKQNDQVSFASLVEELKKVI 803

Query: 308  EQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLE----------TRVR 357
             +     + V+ELL+ + L   N E T Q L     +  + I  ++          ++V+
Sbjct: 804  HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ 863

Query: 358  ELEQTLQASEEQLQQSKGIVAAQETQ-------IQELAAANQE-SSHVQQQALALEQQFL 409
            EL+  L+  EEQ+   K ++  +E         +Q+L   N+   +HVQ+ A    ++  
Sbjct: 864  ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923

Query: 410  ERTQALEAQIV------------ALERTRAADQTTAEQGMRQLEQEN-------AALKEC 450
              +Q  E +IV            A+ + R +D ++  Q ++ ++ EN         LK+ 
Sbjct: 924  SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 983

Query: 451  RNEYERSLQNHQFELKKLKEEWSQREIVSV-----AMAQALEEVRKQREEFQQQAANLTA 505
              +   S   H+  LK + E   ++EI  +     ++  A+E  RK+  + +++      
Sbjct: 984  NYQQASSFPPHEELLKVISER--EKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAME 1041

Query: 506  IIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAE 565
             +   E+ L++K     ++ Q+  Q+E     A   + +L  ++     L   E     E
Sbjct: 1042 ALASTEKMLQDKVNKTSKERQQ--QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE 1099

Query: 566  QEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQD 625
            ++    + G   +E + V E  +        + QL          V A     LQK ++ 
Sbjct: 1100 KKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC---EKYKSVLAETEGILQKLQRS 1156

Query: 626  LEQQ-------LLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFE--VREKPGPEMAN 676
            +EQ+       + E +KTIKQMQ       + L+   ++R +N+  E   RE+   EM  
Sbjct: 1157 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE---RLRSENKDIENLRREREHLEMEL 1213

Query: 677  MAPSVTNNTDLTDAREINFEYLKHVVLKF-----MSCRESEAFHLIKA 719
                +  +T +T+ RE+  + L  +  K       + R++E  +L+KA
Sbjct: 1214 EKAEMERSTYVTEVRELK-DLLTELQKKLDDSYSEAVRQNEELNLLKA 1260



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 126/637 (19%), Positives = 275/637 (43%), Gaps = 54/637 (8%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQE----Q 109
            E +   +  ++E+++ +E  L     QV      KE+   A+     S  ++ Q+    Q
Sbjct: 731  EQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAIRTENSSLTKEVQDLKAKQ 786

Query: 110  NETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
            N+  Q + A + E L   +  KD +     + LE E   +  + + +++    +   ++E
Sbjct: 787  ND--QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEE 844

Query: 170  MDELEGFQQQELS------KIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS 223
            +  ++  + Q+LS      +++++L  KEE +  M+  LE + ++L+ T + L       
Sbjct: 845  IGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ------ 898

Query: 224  SDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQE---LQALIQQLSIDLQ 280
             DL ++ E L+ H   + +      +S +  E     L++KE E   L+A++++   DL 
Sbjct: 899  -DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 957

Query: 281  KVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA 340
              T   Q+ +D     + ++  L+++  Q  S     +ELLK  +  E+ +     +L +
Sbjct: 958  SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 1017

Query: 341  ARSS---QAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHV 397
             + +   Q K  N L  +  E  + L AS E++ Q K    ++E Q Q++ A   E+  V
Sbjct: 1018 LKDAVEHQRKKNNDLREKNWEAMEAL-ASTEKMLQDKVNKTSKERQ-QQVEAVELEAKEV 1075

Query: 398  QQQ-----ALALEQQFLERTQALE--AQIVALERTRAADQTTAEQGMRQLEQENAALKEC 450
             ++     ++     + E     E  A+      + + +    E  +++ ++ +  L+  
Sbjct: 1076 LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLE 1135

Query: 451  RNEYERSLQNHQFELKKLKEEWSQREIV-SVAMAQALEEVRKQREEFQQQAANLTAIIDE 509
              +Y+  L   +  L+KL+    Q E    V + ++ + +++ +  F      L  +  E
Sbjct: 1136 CEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE 1195

Query: 510  KE--QNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAEL-EALRTLKAEEAAVVAEQ 566
             +  +NLR + E L   E E+ + E   ++ + ++ +L+  L E  + L    +  V + 
Sbjct: 1196 NKDIENLRREREHL---EMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1252

Query: 567  EDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEV--GAMDLTQLQK--- 621
            E+L  L+  L      +       + +   + +   +      ++   A D T ++    
Sbjct: 1253 EELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDV 1312

Query: 622  ----EKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKE 654
                E  + E   +  N+T+ Q+QQ +  + + L KE
Sbjct: 1313 SPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1349



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 132/667 (19%), Positives = 270/667 (40%), Gaps = 77/667 (11%)

Query: 41  SGDDFASDGSSSRED--LSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKH 98
           +G+   SD  S   D  LS  L   ++Q+  +   + + +  VR  +K ++K +  LE+ 
Sbjct: 69  NGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQ 128

Query: 99  --QDSSMRKFQEQN-ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQE 155
             ++S   K   +  E     +       A A  +K  +   K    +++K + T  +  
Sbjct: 129 VIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPS 188

Query: 156 MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEE 215
            + +++ L Q   E  +  G  +++ S  K    +K E++   E  + A T         
Sbjct: 189 KRQEALPLHQ---ETKQESGSGKKKASSKK----QKTENVFVDEPLIHATT------YIP 235

Query: 216 LMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL 275
           LM+ N  SS +  K E +      L+  +   I  K+G +   T  +++  E++   +  
Sbjct: 236 LMD-NADSSPVVDKREVID----LLKPDQVEGI-QKSGTKKLKTETDKENAEVK--FKDF 287

Query: 276 SIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGE-----EHVQELLKEKTLAEQN 330
            + L+ +     E   V+  L+EK   ++  L+++  GE       +QE  K+K LA   
Sbjct: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQE--KDKLLAAVK 345

Query: 331 -----LEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQ 385
                 +D  +QL     ++ +  N + TR+++   TL+  E  + Q+K  V+ QETQ  
Sbjct: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE-KEHNVFQNKIHVSYQETQQM 404

Query: 386 ELA------AANQESSHVQQQ------ALALEQQFLERTQALEAQIVALERTRAADQTT- 432
           ++           E +H++Q+      A++     LE  Q+ E   +  +  R  ++ T 
Sbjct: 405 QMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTE 464

Query: 433 --------------AEQGMR----QLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQ 474
                         AEQ       QL++     +E ++   +    H+   + L+ ++  
Sbjct: 465 KTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVA 524

Query: 475 REIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERG 534
           +E    ++   L +    +++ +Q+   L     E EQ    K E L  + Q+IL+    
Sbjct: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLM----ESEQKRVNKEESLQMQVQDILEQNEA 580

Query: 535 HNSALLQIHQLQAELEALRTLKAEEAAVVAEQE-DLLRLRGPLQAEALSVNESHVTSRAM 593
             + + Q H   A   +   L  E   V+AE++  + +    L +E   +       + +
Sbjct: 581 LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDI 640

Query: 594 QDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQK 653
           Q+  F L         +  A +      E + ++Q +  K+  I+ +++++        +
Sbjct: 641 QNMNFLL--KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698

Query: 654 ELKIRPD 660
           E KI  D
Sbjct: 699 EFKILND 705



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 79/363 (21%), Positives = 151/363 (41%), Gaps = 49/363 (13%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQK----IKEKLEIALEKH-------QDSS 102
            E+L   +  R ++I  L   L    + V + +K    ++EK   A+E         QD  
Sbjct: 995  EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1054

Query: 103  MRKFQEQNETFQANRAKMAEGLALALARKDQ-------EWSEKMDQLEKEKNILTAQLQE 155
             +  +E+ +  +A   +  E L     +          EW    ++  KE    T+  +E
Sbjct: 1055 NKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1114

Query: 156  MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELS-RTQE 214
            +K     L  +  E DE+    Q E  K K +L + E  L K+++ +E    +   +  E
Sbjct: 1115 VKV----LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDE 1170

Query: 215  ELMNSNQMSSDLSQKLEELQRHYS------TLEEQRDHVIASKTGAESKITALEQKEQEL 268
                  QM S  +   +EL+R  S       L  +R+H+      AE + +    + +EL
Sbjct: 1171 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL 1230

Query: 269  QALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAE 328
            + L+ +L   L    +E   + + +  L+   A L + L +  + +   Q++  +   A+
Sbjct: 1231 KDLLTELQKKLDDSYSEAVRQNEELNLLK---AQLNETLTKLRTEQNERQKVAGDLHKAQ 1287

Query: 329  QNLEDTRQQLLAA----------------RSSQAKAIN-TLETRVRELEQTLQASEEQLQ 371
            Q+LE  + +++ A                 SS+ + ++ +L   V +L+Q LQA  +QL 
Sbjct: 1288 QSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLT 1347

Query: 372  QSK 374
            + K
Sbjct: 1348 KEK 1350


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  116 bits (291), Expect = 7e-26
 Identities = 157/751 (20%), Positives = 315/751 (41%), Gaps = 91/751 (12%)

Query: 6    KKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSRED----LSSQLL 61
            K+K A E  V         +  +++K +              D   + ED    L+   +
Sbjct: 970  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI 1029

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSM---RKFQEQNETFQANRA 118
            +  +Q+  LE  L    +   +L++ K KLE  L+  Q+S+M      Q+ +E  +    
Sbjct: 1030 KLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEF 1089

Query: 119  KMA---------EGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDE 169
            +M+         + L + L +K +E   ++++LE+E     A   + + Q  +L +  +E
Sbjct: 1090 EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149

Query: 170  MDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMS-SDLSQ 228
            + E         S    M  K+E    KM ++LE  T +   T   L   +  S ++L +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1209

Query: 229  KLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQE 288
            +++ LQR    LE+++  +        S +  + + +  L+ + + L   L ++  + +E
Sbjct: 1210 QIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEE 1269

Query: 289  KEDVITHLQEKVASLE-------KRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQL--- 338
            ++ +I  L  + A L+       ++L++    +  V +L + K    Q +E+ ++QL   
Sbjct: 1270 QQRLINDLTAQRARLQTESGEYSRQLDEK---DTLVSQLSRGKQAFTQQIEELKRQLEEE 1326

Query: 339  LAARSSQAKAINT-------LETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAAN 391
            + A+S+ A A+ +       L  +  E ++     +  + ++   VA   T+ +  A   
Sbjct: 1327 IKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR 1386

Query: 392  QESSHVQQQALALE-QQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAAL--- 447
             E     ++ LA   Q   E  +A+ A+  +LE+T+   Q   E  M  +E+ NAA    
Sbjct: 1387 TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL 1446

Query: 448  -KECRN-------------EYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQR 493
             K+ RN             E    L+  Q E + L  E  + +         LE ++++ 
Sbjct: 1447 DKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506

Query: 494  EEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQ-----LQAE 548
            +  QQ+ ++LT  I E  + + E  ++  Q EQE  +L+     A   +       L+ +
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566

Query: 549  LEALRTLKAEEAAVVAEQEDLL------------RLRGPLQAEALSVNESHVTSRAMQDP 596
            LE L  +K+E    +AE+++ +             ++  L AE  S N++    + M+  
Sbjct: 1567 LE-LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1625

Query: 597  VFQLPT-----------AGRTPNGEVGAMDLTQLQ-----KEKQDLEQQLLEKNKTIKQM 640
            + ++             A R        +  TQL      + ++DL++QL    +    +
Sbjct: 1626 LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLL 1685

Query: 641  QQRMLELRKTLQKELKIR--PDNELFEVREK 669
            Q  + ELR TL++  + R   + EL +  E+
Sbjct: 1686 QAEIEELRATLEQTERSRKIAEQELLDASER 1716



 Score =  107 bits (267), Expect = 4e-23
 Identities = 132/609 (21%), Positives = 271/609 (44%), Gaps = 60/609 (9%)

Query: 71   EARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALAR 130
            E  +++  E+    ++   K E   ++ ++  +   QE+N+  Q      A+ LA A   
Sbjct: 850  EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKND-LQLQVQAEADSLADA--- 905

Query: 131  KDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLK 190
                  E+ DQL K K  L A+++E+  ++ +  +   E+   +   + E S++K  +  
Sbjct: 906  -----EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 960

Query: 191  KEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQR-HYSTLEEQRDHVIA 249
             E +L K+E+E  A   ++    EE+   ++  + L+++ + LQ  H  TL++ +     
Sbjct: 961  LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDK 1020

Query: 250  SKTGAESKITALEQKEQELQALIQQ--------------LSIDLQKVTAETQEKEDVITH 295
              T  ++KI  LEQ+  +L+  ++Q              L  DL+     T + E+    
Sbjct: 1021 VNTLTKAKI-KLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQ 1079

Query: 296  LQEK-------VASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKA 348
            L EK       ++ L+ ++E   +    +Q+ +KE    +  +E+  +++ A R+S+AKA
Sbjct: 1080 LDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKE---LQARIEELEEEIEAERASRAKA 1136

Query: 349  INTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQF 408
                E +  +L + L+   E+L+++ G  +AQ      +    +  +  Q+    LE+  
Sbjct: 1137 ----EKQRSDLSRELEEISERLEEAGGATSAQ------IEMNKKREAEFQKMRRDLEEAT 1186

Query: 409  LERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKL 468
            L+     EA    L +  A       + +  L++    L++ ++E +  + +    ++ +
Sbjct: 1187 LQH----EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETV 1242

Query: 469  KEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEI 528
             +     E +  A+   L E++ + EE Q+   +LTA     +    E +  L +K+  +
Sbjct: 1243 SKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLV 1302

Query: 529  LQLERGHNSALLQIHQLQAELEALRTLKAEEA---AVVAEQEDLLRLRGPLQAEALSVNE 585
             QL RG  +   QI +L+ +LE    +KA+ A   A+ + + D   LR   + E  +  E
Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLE--EEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE 1360

Query: 586  SHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLT-QLQKEKQDLEQQLLEKNKTIKQMQQRM 644
                       V Q  T       E  A+  T +L++ K+ L Q+L +  + ++ +  + 
Sbjct: 1361 LQRAMSKANSEVAQWRT-----KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKC 1415

Query: 645  LELRKTLQK 653
              L KT Q+
Sbjct: 1416 ASLEKTKQR 1424



 Score =  105 bits (262), Expect = 2e-22
 Identities = 137/647 (21%), Positives = 287/647 (44%), Gaps = 63/647 (9%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQ-DSSMRK 105
            ++ +   E+++++L  +    RKLE   S+  + + +L+    K+E   EKH  ++ ++ 
Sbjct: 927  TERAEDEEEINAELTAKK---RKLEDECSELKKDIDDLELTLAKVE--KEKHATENKVKN 981

Query: 106  FQEQNETFQANRAKMA-EGLALALARKD-----QEWSEKMDQLEKEKNILTAQLQEMKNQ 159
              E+        AK+  E  AL  A +      Q   +K++ L K K  L  Q+ +++  
Sbjct: 982  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS 1041

Query: 160  SMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNS 219
                 + R +++  +   + +L   +   +  E    +++++L+ +  E+S  Q ++ + 
Sbjct: 1042 LEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101

Query: 220  NQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDL 279
              +   L +K++ELQ     LEE+ +   AS+  A       E++  +L   ++++S  L
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEAERASRAKA-------EKQRSDLSRELEEISERL 1154

Query: 280  QKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEK------TLAEQ--NL 331
            ++    T  + ++    + +   + + LE+     E     L++K       L EQ  NL
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1214

Query: 332  EDTRQQLLAARSSQAKAINTLETRVR-------ELEQTLQASEEQLQQSKGIVAAQETQI 384
            +  +Q+L   +S     I+ L + +         LE+  +A E+QL + K     Q+  I
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274

Query: 385  QELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQEN 444
             +L A   + + +Q ++    +Q  E+    +  +  L R + A     E+  RQLE+E 
Sbjct: 1275 NDLTA---QRARLQTESGEYSRQLDEK----DTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327

Query: 445  AALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLT 504
             A     +  + S  +     ++ +EE   +  +  AM++A  EV + R +++  A   T
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387

Query: 505  AIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQ-LQAELEAL----RTLKAEE 559
              ++E ++ L ++    LQ  +E ++      ++L +  Q LQ E+E L        A  
Sbjct: 1388 EELEEAKKKLAQR----LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAAC 1443

Query: 560  AAVVAEQED----LLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAM- 614
            AA+  +Q +    L   +   +     +  S   SR++   +F++  A      ++  + 
Sbjct: 1444 AALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLK 1503

Query: 615  -DLTQLQKEKQDLEQQLLEKNKTI-------KQMQQRMLELRKTLQK 653
             +   LQ+E  DL +Q+ E  K I       KQ++Q   EL+  L++
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEE 1550



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 115/518 (22%), Positives = 234/518 (45%), Gaps = 68/518 (13%)

Query: 183  KIKHML--LKKEESLGKMEQELEARTRELSRTQ-------EELMNSNQMSSDLSQKLEEL 233
            KIK +L   + E+ +  M++E E    EL++T+       E+++   Q  +DL  +++  
Sbjct: 839  KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898

Query: 234  QRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVI 293
                +  EE+ D +I +K   E+KI  + ++ ++ + +  +L+   +K+  E  E +  I
Sbjct: 899  ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958

Query: 294  THLQEKVASLE----------KRLEQNLSG-EEHVQELLKEKTLAEQNLEDTRQQLLAAR 342
              L+  +A +E          K L + ++G +E + +L KEK    + L++  QQ L   
Sbjct: 959  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK----KALQEAHQQTLDDL 1014

Query: 343  SSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQAL 402
             ++   +NTL     +LEQ +   E  L+Q K I    E   ++L     +    Q+  +
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG---DLKLAQESTM 1071

Query: 403  ALE---QQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYE---- 455
             +E   QQ  E+ +  E ++  L+     +Q    Q  +++++  A ++E   E E    
Sbjct: 1072 DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERA 1131

Query: 456  --RSLQNHQFELKKLKEEWSQR-EIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQ 512
                 +  + +L +  EE S+R E    A +  +E  +K+  EFQ+              
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR------------ 1179

Query: 513  NLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALR-TLKAEEAAVVAEQEDLLR 571
              R+  E  LQ E     L + H  ++ ++ +    L+ ++  L+ E++ +  E +D   
Sbjct: 1180 --RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD--- 1234

Query: 572  LRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLT----QLQKEKQDLE 627
            L   ++  + +        RA++D + ++ T        +   DLT    +LQ E  +  
Sbjct: 1235 LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIN--DLTAQRARLQTESGEYS 1292

Query: 628  QQLLEKNKTIKQMQ-------QRMLELRKTLQKELKIR 658
            +QL EK+  + Q+        Q++ EL++ L++E+K +
Sbjct: 1293 RQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1330



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 154/722 (21%), Positives = 288/722 (39%), Gaps = 91/722 (12%)

Query: 5    LKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRN 64
            L +++ E +   +  GGAT     ++K+  A                 R DL    L+  
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEF------------QKMRRDLEEATLQHE 1190

Query: 65   EQIRKLEARLSD----YAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKM 120
                 L  + +D      EQ+ NLQ++K+KLE      ++ S  K +  +          
Sbjct: 1191 ATAATLRKKHADSVAELGEQIDNLQRVKQKLE------KEKSEMKMEIDDLASNMETVSK 1244

Query: 121  AEG----LALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGF 176
            A+G    +  AL  +  E   K ++ ++  N LTAQ   ++ +S    ++ DE D L   
Sbjct: 1245 AKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS- 1303

Query: 177  QQQELSKIKHMLLKKEESLGK-MEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQR 235
               +LS+ K    ++ E L + +E+E++A++          + S++   DL      L+ 
Sbjct: 1304 ---QLSRGKQAFTQQIEELKRQLEEEIKAKS-----ALAHALQSSRHDCDL------LRE 1349

Query: 236  HYSTLEEQRDHVIASKTGAESKITALEQK-EQELQALIQQLSIDLQKVTAETQEKEDVIT 294
             Y   +E +  +  + + A S++     K E +     ++L    +K+    Q+ E+ + 
Sbjct: 1350 QYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409

Query: 295  HLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLET 354
             +  K ASLEK  +Q L  E     +  E+T A     D +Q+      ++ K     E 
Sbjct: 1410 AVNAKCASLEKT-KQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWK--QKCEE 1466

Query: 355  RVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLE---R 411
               ELE + + S     +   I  A E  + +L    +E+ ++QQ+   L +Q  E   R
Sbjct: 1467 THAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1526

Query: 412  TQALEAQIVALERTRAADQTTAEQGMRQLEQENAA-------LKECRNEYERSLQNHQFE 464
               LE     +E+ ++  Q   E+    LE E          L + ++E +R +     E
Sbjct: 1527 IHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1586

Query: 465  LKKLK----------------EEWSQREIVSVA--MAQALEEVRKQREEFQQQAA----- 501
            + ++K                E  S+ + + +   M   L E+  Q     + AA     
Sbjct: 1587 IDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1646

Query: 502  --NLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEAL---RTLK 556
              N  AI+ + + +L +        ++++  +ER  N    +I +L+A LE     R + 
Sbjct: 1647 YRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1706

Query: 557  AEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTS--RAMQDPVFQLPTAGRTPNGEV--G 612
             +E    +E+  LL  +           E+ ++     M+D + +   A       +   
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDA 1766

Query: 613  AMDLTQLQKEKQD---LEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREK 669
            AM   +L+KE+     LE+      +T+K +Q R+ E  +   K  K +       VRE 
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL 1826

Query: 670  PG 671
             G
Sbjct: 1827 EG 1828



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 120/563 (21%), Positives = 248/563 (44%), Gaps = 84/563 (14%)

Query: 52   SREDLSSQLLRRNEQIRKLEARL-SDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQN 110
            ++ +L   + + N ++ +   +  +D  ++   L++ K+KL            ++ Q+  
Sbjct: 1357 AKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA-----------QRLQDAE 1405

Query: 111  ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEM 170
            E  +A  AK A  L     R   E  + M  +E+      A  ++ +N    L + + + 
Sbjct: 1406 EHVEAVNAKCAS-LEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKC 1464

Query: 171  DE----LEGFQQQ------ELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSN 220
            +E    LE  Q++      EL KIK+     EESL     +LE   RE    Q+E+ +  
Sbjct: 1465 EETHAELEASQKESRSLSTELFKIKNAY---EESL----DQLETLKRENKNLQQEISDLT 1517

Query: 221  QMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQ 280
            +  ++  +++ EL++    +E+++  + A+   AE+ +   E K   +Q  + Q+  ++ 
Sbjct: 1518 EQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1577

Query: 281  KVTAETQEKEDVI--THLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQL 338
            +  AE  E+ D +   H++  V S++  L+  +       + ++ K   E +L +   QL
Sbjct: 1578 RKIAEKDEEIDQMKRNHIR-IVESMQSTLDAEIRSR---NDAIRLKKKMEGDLNEMEIQL 1633

Query: 339  LAARSSQAKAINT-------LETRVRELEQTLQASE---EQLQQSKGIVAAQETQIQELA 388
              A    A+A+         L+     L+  L++ E   EQL   +      + +I+EL 
Sbjct: 1634 NHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELR 1693

Query: 389  AANQESSHVQQQALALEQQFL---ERTQALEAQIVALERTRAADQTTAEQGMRQLEQENA 445
            A  +++   ++ A   EQ+ L   ER Q L  Q  +L  T+   +T   Q   ++E    
Sbjct: 1694 ATLEQTERSRKIA---EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED--- 1747

Query: 446  ALKECRNEYERSL----------------QNHQFELKKLKEEWSQ-----REIVSVAMAQ 484
             ++E RN  E++                 Q+    L+++K+   Q     +  +  A   
Sbjct: 1748 IIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807

Query: 485  ALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQL-----ERGHNSAL 539
            AL+  +KQ ++ + +   L   ++ +++   E  + L + E+++ +L     E   N   
Sbjct: 1808 ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILR 1867

Query: 540  LQ--IHQLQAELEALRTLKAEEA 560
            LQ  + +LQA++++ +  +AEEA
Sbjct: 1868 LQDLVDKLQAKVKSYKR-QAEEA 1889



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 76/359 (21%), Positives = 153/359 (42%), Gaps = 61/359 (16%)

Query: 51   SSREDLSSQLLRRNEQIR---KLEARLSDY-----------AEQVRNLQKIKEKLEIALE 96
            S +  L +++  RN+ IR   K+E  L++            AE +RN +  +  L+   +
Sbjct: 1600 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT-Q 1658

Query: 97   KHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQL--- 153
             H D ++R  ++  E     +  M E  A  L  + +E    ++Q E+ + I   +L   
Sbjct: 1659 LHLDDALRSQEDLKE-----QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1713

Query: 154  ----QEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTREL 209
                Q +  Q+ +L   + +++      Q E+  I       EE   K   +      EL
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEEL 1773

Query: 210  SRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQ 269
             + Q+   +  +M  +L Q +++LQ      E+     +A K G + +I  LE + +EL+
Sbjct: 1774 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ-----LALK-GGKKQIQKLEARVRELE 1827

Query: 270  ALI---QQLSID-----------LQKVTAETQEK-------EDVITHLQEKVASLEKRLE 308
              +   Q+ +++           ++++T +T+E        +D++  LQ KV S +++ E
Sbjct: 1828 GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1887

Query: 309  QNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASE 367
            +    EE     L +    +  LE+  ++   A S     +N L  + RE+   + + E
Sbjct: 1888 E---AEEQSNVNLSKFRRIQHELEEAEERADIAESQ----VNKLRVKSREVHTKIISEE 1939


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  115 bits (289), Expect = 1e-25
 Identities = 145/690 (21%), Positives = 309/690 (44%), Gaps = 105/690 (15%)

Query: 54   EDLSSQLLRRN----EQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQ 109
            ED +S+ ++      ++I +  ++L++  E+ +NL KI+ K E+ +   ++   ++ + +
Sbjct: 991  EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR 1050

Query: 110  NETFQANR---------------------------AKMAEGLALALARKDQEWSEKMDQL 142
             E  +A R                           AK  E L  ALAR D E   K + L
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110

Query: 143  E--KEKNILTAQLQ---EMKNQSMNLF--QRRDEMDELEGFQQQ------ELSKIKHMLL 189
            +  +E     A+LQ   E +  S N    Q+RD  +ELE  + +        +  + +  
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170

Query: 190  KKEESLGKMEQELEARTRELSRTQEELMNSNQMS-SDLSQKLEELQRHYSTLEEQRDHVI 248
            K+E+ + ++++ LE  T+      +++   +  +  +LS++LE+ +R  + LE+ +  + 
Sbjct: 1171 KREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230

Query: 249  ASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLE 308
                    ++  L+Q + E +   ++L   +Q++ A+  E + +   L EK + L+  L+
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290

Query: 309  Q--------------------NLSGE-EHVQELLKEKTLAEQN-------LEDTRQQLLA 340
                                 +L  + +  QELL+E+T  + N       LE+ +  L  
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350

Query: 341  ARSSQAKAINTLETRVRELEQTLQASEEQLQQSKG-IVAAQETQIQELAAANQESSHVQQ 399
             +  + +A   LE +V  L+  L  +++++    G I + +E + + L  A   S  +++
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410

Query: 400  QALALEQQFLERT-----QALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEY 454
            +ALA ++  LE+T     Q L+   V L+  R    +  E+  ++ +Q  A  K     Y
Sbjct: 1411 KALAYDK--LEKTKNRLQQELDDLTVDLDHQRQV-ASNLEKKQKKFDQLLAEEKSISARY 1467

Query: 455  ERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNL 514
                     E  + + E  ++E  ++++A+ALEE  + +EEF++Q   L A   + E  +
Sbjct: 1468 AE-------ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA---DMEDLM 1517

Query: 515  REKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALR-TLKAEEAAVVAEQEDLLRLR 573
              K +V     + + +LE+   +   Q+ +++ +LE L   L+A E A +  + ++  ++
Sbjct: 1518 SSKDDV----GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573

Query: 574  GPLQAEALSVNESHVTSRAM---QDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQL 630
               + +  + +E +   + +   Q    +           +      +++ + +DLE Q+
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633

Query: 631  LEKNK----TIKQMQQRMLELRKTLQKELK 656
               NK     IKQ+++   ++ K  Q+EL+
Sbjct: 1634 EAANKARDEVIKQLRKLQAQM-KDYQRELE 1662



 Score =  112 bits (281), Expect = 1e-24
 Identities = 136/676 (20%), Positives = 306/676 (45%), Gaps = 75/676 (11%)

Query: 47   SDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALE------KHQD 100
            ++    R  L+++     E +  LE+R+ +  E+ + LQ  K+K++  ++        ++
Sbjct: 904  AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963

Query: 101  SSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQS 160
             + +K Q +  T +A   KM E + L L  ++ ++ ++   +E      ++QL E + ++
Sbjct: 964  GARQKLQLEKVTAEAKIKKMEEEI-LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022

Query: 161  MNLFQRRDEMDEL----------EGFQQQELSKIKHML----LKKEESLGKMEQELEART 206
             NL + R++ + +          E   +QEL K K  L       ++ + +++ +++   
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082

Query: 207  RELSRTQEELMNSNQMSSDLS-------QKLEELQRHYSTLEEQRDHVIASKTGAESKIT 259
             +L++ +EEL  +     D +       + + ELQ   + L+E  +   AS+  A     
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA----- 1137

Query: 260  ALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEE-HVQ 318
              E+++++L   ++ L  +L+     T  ++++ T  +++VA L+K LE+     E  +Q
Sbjct: 1138 --EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195

Query: 319  ELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVA 378
            ++ +    A + L +  +Q    +++  K    LET  +EL   ++  ++   +S+    
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK 1255

Query: 379  AQETQIQELAAANQESSHVQ----QQALALEQQ-----------------FLERTQALEA 417
              + Q+QEL A   E   ++    ++A  L+ +                 F +   +LE+
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315

Query: 418  QI-----VALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEW 472
            Q+     +  E TR   +      +RQLE+E  +L+E + E E + +N + ++  L+ + 
Sbjct: 1316 QLQDTQELLQEETR--QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373

Query: 473  SQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEK--EQNLREKTEVLLQKEQEILQ 530
            +  +         +E + + +++  + A  L+  ++EK    +  EKT+  LQ+E + L 
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433

Query: 531  LERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTS 590
            ++  H   +     L+ + +    L AEE ++ A   +    R   +AEA       ++ 
Sbjct: 1434 VDLDHQRQVAS--NLEKKQKKFDQLLAEEKSISARYAE---ERDRAEAEAREKETKALSL 1488

Query: 591  RAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELR-- 648
                +   +        N ++ A D+  L   K D+ + + E  K+ + ++Q++ E+R  
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRA-DMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547

Query: 649  -KTLQKELKIRPDNEL 663
             + L+ EL+   D +L
Sbjct: 1548 LEELEDELQATEDAKL 1563



 Score =  108 bits (271), Expect = 1e-23
 Identities = 143/672 (21%), Positives = 286/672 (42%), Gaps = 88/672 (13%)

Query: 39   ADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEK-------L 91
            A+  +DF S+  +SR     Q    +E++  L+  L D  +     Q+++ K       L
Sbjct: 1121 AELQEDFESE-KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179

Query: 92   EIALEKHQDSSMRKFQ-----------------EQNETFQANRAKMAEGLAL---ALARK 131
            + ALE+   +   + Q                 EQ + F+AN  K  +GL      LA +
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239

Query: 132  DQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKK 191
             +   +   + E ++  L AQ+QE+  +     + R E+ E     Q EL  +  +L + 
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299

Query: 192  EESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASK 251
            E+   K  ++  +   +L  TQE L    +   +LS ++ +L+   ++L+EQ        
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ-------- 1351

Query: 252  TGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEK--EDVITHLQEKVASLEKRLEQ 309
                      +++E+E +  +++  + LQ   A+T++K  +D+ T     + SLE+  ++
Sbjct: 1352 ----------QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGT-----IESLEEAKKK 1396

Query: 310  NLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQ 369
             L   E + + L+EK LA   LE T+ +L          ++        LE+  +  ++ 
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456

Query: 370  LQQSKGIVA--AQETQIQELAAANQES-----SHVQQQALALEQQFLERTQALEAQIVAL 422
            L + K I A  A+E    E  A  +E+     +   ++AL  +++F  + + L A +  L
Sbjct: 1457 LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516

Query: 423  ERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAM 482
                 + +    + + +LE+   AL++   E    L+  + EL+  ++   + E+   AM
Sbjct: 1517 ----MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572

Query: 483  AQALEEVRKQREEFQQQAANL---------TAIIDEKEQNL-----REKTEV-LLQKEQE 527
                E   + R+E  ++   L           + DE++Q       ++K E+ L   E +
Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 1632

Query: 528  ILQLERGHNSALLQIHQLQAELE----ALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSV 583
            I    +  +  + Q+ +LQA+++     L   +A    + A+ ++  +    L+AE L +
Sbjct: 1633 IEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL 1692

Query: 584  NESHVTSRAMQDPVFQL--PTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQ 641
             E   +S   +    Q     A    N   G    + L  EK+ LE ++ +  + +++ Q
Sbjct: 1693 QEELASSERARRHAEQERDELADEITNSASGK---SALLDEKRRLEARIAQLEEELEEEQ 1749

Query: 642  QRMLELRKTLQK 653
              M  L    +K
Sbjct: 1750 SNMELLNDRFRK 1761



 Score =  105 bits (261), Expect = 2e-22
 Identities = 136/565 (24%), Positives = 248/565 (43%), Gaps = 90/565 (15%)

Query: 133  QEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE 192
            +E   K  QL +EKNIL  QLQ        LF   +EM      ++QEL +I H      
Sbjct: 876  EEMERKHQQLLEEKNILAEQLQA----ETELFAEAEEMRARLAAKKQELEEILH------ 925

Query: 193  ESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKT 252
                    +LE+R  E     + L N  +          ++Q H   LEEQ D    ++ 
Sbjct: 926  --------DLESRVEEEEERNQILQNEKK----------KMQAHIQDLEEQLDEEEGARQ 967

Query: 253  GAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLS 312
              + +    E K ++++  I  L     K   E +  ED I     ++A  E++  +NL+
Sbjct: 968  KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK-AKNLA 1026

Query: 313  GEEHVQEL--------LKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQ 364
               + QE+        LK++    Q LE  +++L    +     I  L+ ++ EL+  L 
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086

Query: 365  ASEEQLQ------------QSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERT 412
              EE+LQ            ++  +   +E Q Q +A   ++    +      E+Q  + +
Sbjct: 1087 KKEEELQGALARGDDETLHKNNALKVVRELQAQ-IAELQEDFESEKASRNKAEKQKRDLS 1145

Query: 413  QALEAQIVALERTRAADQTTAEQGMR-QLEQENAALKECRNEYERSLQNHQFELKKLKEE 471
            + LEA    LE T   D T A+Q +R + EQE A LK+     E   +NH+ +++ +++ 
Sbjct: 1146 EELEALKTELEDT--LDTTAAQQELRTKREQEVAELKKA---LEEETKNHEAQIQDMRQR 1200

Query: 472  WSQREIVSVAMAQALEEVRKQREEFQQQAANLTAI---IDEKEQNLREKTEVLLQKEQEI 528
                       A ALEE+ +Q E+ ++  ANL      ++   + L  + +VL Q + E 
Sbjct: 1201 ----------HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250

Query: 529  LQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLL-------RLRGPLQAEAL 581
                +  ++ + ++H   +E + LR   AE+A+ +  + D +         +G   A+  
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310

Query: 582  SVNESHV--TSRAMQDPVFQ-LPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIK 638
            +  ES +  T   +Q+   Q L  + R          + QL++EK  L++Q  E+ +  K
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSR----------IRQLEEEKNSLQEQQEEEEEARK 1360

Query: 639  QMQQRMLELRKTLQKELKIRPDNEL 663
             +++++L L+  L  + K + D++L
Sbjct: 1361 NLEKQVLALQSQL-ADTKKKVDDDL 1384



 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 132/669 (19%), Positives = 276/669 (41%), Gaps = 103/669 (15%)

Query: 4    KLKKKIAEETAVAQRP--GGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLL 61
            +L+ ++AE+ +  Q      +T +  +  K    +  A S +    D     ++ + Q L
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL 1332

Query: 62   RRNEQIRKLEARLSDYAEQVRNLQKIKEKLE---IALEKHQDSSMRKFQEQNETFQANRA 118
              + +IR+LE   +   EQ    ++ ++ LE   +AL+     + +K  +   T ++   
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392

Query: 119  KMAEGL--ALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGF 176
               + L  A AL+++ +E +   D+LEK KN L    QE+ + +++L  +R     LE  
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ---QELDDLTVDLDHQRQVASNLEKK 1449

Query: 177  QQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRH 236
            Q+    K   +L +++    +  +E +    E    + + ++  +   +  +  EE +R 
Sbjct: 1450 QK----KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQ 1505

Query: 237  YSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHL 296
               L    + +++SK      +  LE+ ++ L+  ++++   L+++  E Q  ED    L
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565

Query: 297  QEKVASLEKRLEQNLS-----GEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKA--- 348
            +  + +++ + E++L       EE  + L+K+    E  LED R+Q   A +S+ K    
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625

Query: 349  INTLETRV-------------------------RELEQTLQASEEQLQQSKGI------V 377
            +  LE ++                         RELE+   + +E   QSK        +
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685

Query: 378  AAQETQIQE-LAAANQESSHVQQQALALEQQF----------LERTQALEAQIVALERTR 426
             A+  Q+QE LA++ +   H +Q+   L  +           L+  + LEA+I  LE   
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745

Query: 427  AADQTTAE-------------------------------QGMRQLEQENAALKECRNEYE 455
              +Q+  E                                  +QLE++N  LK    E E
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELE 1805

Query: 456  RSLQNH--------QFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAII 507
             ++++         + ++ +L+E+  Q      A  + +    K+ +E   Q  +     
Sbjct: 1806 GAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA 1865

Query: 508  DEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQE 567
            D+ ++ + +    + Q ++++ + E     A     +LQ EL+         +  V+  +
Sbjct: 1866 DQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925

Query: 568  DLLRLRGPL 576
            + LR  GP+
Sbjct: 1926 NRLRRGGPI 1934


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  115 bits (287), Expect = 2e-25
 Identities = 164/668 (24%), Positives = 295/668 (44%), Gaps = 116/668 (17%)

Query: 55   DLSSQLLRRNEQIRKL-------EARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQ 107
            + SSQ     E+++ L       EA ++D  +++R  +K +++LE  L++  D    + Q
Sbjct: 1035 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE-KLKRRLDGESSELQ 1093

Query: 108  EQN-------ETFQANRAKMAEGLALALARKDQEWSEKMDQLE--KEKNILTAQLQE-MK 157
            EQ        E  +A   +  E L  ALAR + E   +   L+  +E     A+ QE ++
Sbjct: 1094 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLE 1153

Query: 158  NQSMNLF----QRRDEMDELEGFQQQ------ELSKIKHMLLKKEESLGKMEQELEARTR 207
            ++ +       QRRD  +ELE  + +        +  + +  K+E+ + ++++ LE  TR
Sbjct: 1154 SERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1213

Query: 208  ELSRTQEELMNSN-QMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQ 266
                  +EL   + Q   +L+++LE+ +R     E+ R  + A  +   +++++L+   Q
Sbjct: 1214 IHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1273

Query: 267  ELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSG-----EEHVQELL 321
            E +   ++L + LQ+V     + E       EK+   +  LE N+SG     E     L 
Sbjct: 1274 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-NVSGALNEAESKTIRLS 1332

Query: 322  KEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQE 381
            KE +  E  L D ++ L      + +A   L +RVR +E       EQL++     AA+E
Sbjct: 1333 KELSSTEAQLHDAQELL----QEETRAKLALGSRVRAMEAEAAGLREQLEEE---AAARE 1385

Query: 382  TQIQELAAANQESSH---------------------VQQQALALEQQFLERTQALEAQIV 420
               +EL  A  + S                        ++A AL Q+  E+T+ ++    
Sbjct: 1386 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDR--- 1442

Query: 421  ALERTRAADQTTAEQGMRQLEQEN---AALKECRNEYERSLQNHQF-------ELKKLKE 470
             LER R   Q   +     LEQ+    + L++ + ++++ L   +        E ++ + 
Sbjct: 1443 -LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1501

Query: 471  EWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQ 530
            E  +RE  ++++ +ALEE ++ REE ++Q   L A   E E  L  K +V     + + +
Sbjct: 1502 EGREREARALSLTRALEEEQEAREELERQNRALRA---ELEALLSSKDDV----GKSVHE 1554

Query: 531  LERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTS 590
            LER    A    + L+A++  L      E  + A ++  LRL   +QA    +   H   
Sbjct: 1555 LERACRVAEQAANDLRAQVTEL------EDELTAAEDAKLRLEVTVQA----LKTQH--E 1602

Query: 591  RAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLEL--R 648
            R +Q         GR    E G     QL K+ +D E +  E+ K      QR L +  R
Sbjct: 1603 RDLQ---------GR---DEAGEERRRQLAKQLRDAEVERDEERK------QRTLAVAAR 1644

Query: 649  KTLQKELK 656
            K L+ EL+
Sbjct: 1645 KKLEGELE 1652



 Score =  111 bits (277), Expect = 3e-24
 Identities = 138/650 (21%), Positives = 288/650 (44%), Gaps = 61/650 (9%)

Query: 44   DFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEI---ALEKH-- 98
            +  ++   +R  L+++       + +LEAR+ +  E  R +Q  K++L+     LE H  
Sbjct: 926  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 985

Query: 99   -QDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMK 157
             ++ + +K Q +  T +A   K  E L L          ++  +L KE+ +L  +L E  
Sbjct: 986  AEEGARQKLQLEKVTTEAKMKKFEEDLLLL--------EDQNSKLSKERKLLEDRLAEFS 1037

Query: 158  NQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE---ESLGKMEQELEARTRELSRTQ- 213
            +Q+    ++   +++L    +  ++ ++  L K+E   + L K+++ L+  + EL     
Sbjct: 1038 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1097

Query: 214  EELMNSNQMSSDLSQKLEELQRHYSTLEEQ---RDHVIASKTGAESKI------------ 258
            E+   + ++ + L +K EELQ   +  E++   R  ++ S   A++ +            
Sbjct: 1098 EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1157

Query: 259  --TALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLS-GEE 315
              T  E++ ++L   ++ L  +L+     T  ++++ +  +++V  L+K LE+     E 
Sbjct: 1158 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1217

Query: 316  HVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELE---QTLQASEEQLQQ 372
             VQEL +    A   L +  +Q    + +  K    LE  V EL     +LQ + ++ +Q
Sbjct: 1218 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1277

Query: 373  SKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQAL--EAQIVALERTRAADQ 430
             +  +  Q  ++Q  A   + +     + L   Q  LE       EA+   +  ++    
Sbjct: 1278 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1337

Query: 431  TTAE-QGMRQLEQENAALKECRNEYERSLQNHQFELK-KLKEEWSQREIVSVAMAQALEE 488
            T A+    ++L QE    K       R+++     L+ +L+EE + RE     +  A  +
Sbjct: 1338 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1397

Query: 489  VRKQREEFQQQAANLTAIIDEKEQNLREK---TEVLLQKEQEILQLERGHNSALLQIHQL 545
            + + R   +++A  L A  + + +  RE    T+ L +K + + +LERG         +L
Sbjct: 1398 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR-------RRL 1450

Query: 546  QAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGR 605
            Q EL+       ++  +V+  E   R    L AE     E     RA+++   +    GR
Sbjct: 1451 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE-----EKAAVLRAVEERE-RAEAEGR 1504

Query: 606  TPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKEL 655
                E  A+ LT+  +E+Q+  ++L  +N+ ++   + +L  +  + K +
Sbjct: 1505 --EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSV 1552



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 156/675 (23%), Positives = 281/675 (41%), Gaps = 128/675 (18%)

Query: 3    AKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLR 62
            A+  +K+    A  +   GA  +  + SK    S    S +    D     ++ +   L 
Sbjct: 1301 AEAAEKLQRAQAELENVSGA--LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1358

Query: 63   RNEQIRKLEARLSDYAEQVRNLQKIKEKL--EIALEKHQDSSMRKFQEQN-------ETF 113
               ++R +EA  +   EQ+      +E+   E+   + Q S  R+ QE+        E  
Sbjct: 1359 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1418

Query: 114  QANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDEL 173
            +   A+ AE L   LA K    +E +D+LE+ +  L    QE+ + +M+L Q+R  +  L
Sbjct: 1419 RRRAAREAEALTQRLAEK----TETVDRLERGRRRLQ---QELDDATMDLEQQRQLVSTL 1471

Query: 174  EGFQQ---QELSKIKHMLLKKEESLGKME---QELEARTRELSRTQEELMNSNQMSSDLS 227
            E  Q+   Q L++ K  +L+  E   + E   +E EAR   L+R  EE   +        
Sbjct: 1472 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR------- 1524

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
               EEL+R    L  + + +++SK      +  LE+  +  +     L   + ++  E  
Sbjct: 1525 ---EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1581

Query: 288  EKEDVITHLQEKVASLEKRLEQNL-----SGEEHVQELLKEKTLAEQNLEDTRQQLLAAR 342
              ED    L+  V +L+ + E++L     +GEE  ++L K+   AE   ++ R+Q   A 
Sbjct: 1582 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1641

Query: 343  SSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQAL 402
            +++ K    LE    ++    Q  EE ++Q + + A    Q++EL    +E+   +++  
Sbjct: 1642 AARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA----QMKELWREVEETRTSREEIF 1697

Query: 403  ALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQ-----ENAAL-KECRNEYER 456
            +  ++  +R + LEA+++ L+   AA      Q  +  ++      N  L K    E +R
Sbjct: 1698 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1757

Query: 457  SLQNHQFELKK-LKEEWSQREIVSVAMAQALEEVRKQ-----------------REEFQQ 498
             L+    +L++ L+EE S  E+++    + L +V                    R++ ++
Sbjct: 1758 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1817

Query: 499  QAANLTAIIDEK--------------------------EQNLREKT-------------- 518
            Q   L   + E+                          EQ  RE+               
Sbjct: 1818 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1877

Query: 519  EVLLQKEQEIL-------QLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLR 571
            EV+LQ E+E         QLE+G+    L++ QL+ +LE     +AEE A  A+      
Sbjct: 1878 EVVLQVEEERRVADQLRDQLEKGN----LRVKQLKRQLE-----EAEEEASRAQAG---- 1924

Query: 572  LRGPLQAEALSVNES 586
             R  LQ E   V ES
Sbjct: 1925 -RRRLQRELEDVTES 1938



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 121/574 (21%), Positives = 253/574 (44%), Gaps = 75/574 (13%)

Query: 141  QLEKEKN------ILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELS---KIKHM---- 187
            QLE+E++      I++ Q       +   FQ+R +        Q+  +   K++H     
Sbjct: 802  QLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWR 861

Query: 188  LLKKEESL---GKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQR 244
            L  K + L    + ++ L+AR +EL + QE       +    ++++ ELQ   + LEE+R
Sbjct: 862  LFTKVKPLLQVTRQDEVLQARAQELQKVQE-------LQQQSAREVGELQGRVAQLEEER 914

Query: 245  DHVIASKTGAESKITA-LEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASL 303
               +A +  AE+++ A  E+    L A  Q+L + + ++ A   E+E+    +Q +   L
Sbjct: 915  AR-LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRL 973

Query: 304  E---KRLEQNLSGEEHV-QELLKEKTLAEQNLEDTRQQLLA---ARSSQAKAINTLETRV 356
            +   + LE +L  EE   Q+L  EK   E  ++   + LL      S  +K    LE R+
Sbjct: 974  QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1033

Query: 357  RELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALE 416
             E        EE+++    +    E  I ++    ++    +Q+   L+++    +  L+
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1093

Query: 417  AQIVALERTRAADQTTAEQGMRQLEQENAALKE-----CRNEYERSLQNHQFELKKLKEE 471
             Q+V  E+ + A++  A+ G ++ E + A  +       R +  +SL+  Q  L + +E+
Sbjct: 1094 EQMV--EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1151

Query: 472  WSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQL 531
                 +       A  +  KQR +  ++   L   +++   +   + E+  ++EQE+ +L
Sbjct: 1152 LESERV-------ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTEL 1204

Query: 532  E-------RGHNSALLQIHQ--------LQAELEALRTLK-AEEAAVVAEQEDLLRLRGP 575
            +       R H +A+ ++ Q        L  +LE  R  K A E   +A + ++  LR  
Sbjct: 1205 KKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAE 1264

Query: 576  LQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQ-LQKEKQDL-------- 626
            L +   +  E     R ++  + ++   GR  +GE    +  + LQ+ + +L        
Sbjct: 1265 LSSLQTARQEGEQRRRRLELQLQEV--QGRAGDGERARAEAAEKLQRAQAELENVSGALN 1322

Query: 627  --EQQLLEKNKTIKQMQQRMLELRKTLQKELKIR 658
              E + +  +K +   + ++ + ++ LQ+E + +
Sbjct: 1323 EAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1356



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 161/752 (21%), Positives = 309/752 (41%), Gaps = 117/752 (15%)

Query: 3    AKLKKKIAEETAV---AQRPGGATRIPRSVSKESVASMGAD----SGD-DFASDGSSSRE 54
            A+L K + E  A    AQ    + R+ R+ +++    +G +     G+ +   D +++++
Sbjct: 1132 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1191

Query: 55   DLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQ 114
            +L S   +R +++ +L+  L +         +I E     L +    ++ +  EQ E  Q
Sbjct: 1192 ELRS---KREQEVTELKKTLEEET-------RIHEAAVQELRQRHGQALGELAEQLE--Q 1239

Query: 115  ANRAKMA-EGLALALARKDQEWSEKMDQL-------EKEKNILTAQLQEMKNQSMNLFQR 166
            A R K A E   LAL  +  E   ++  L       E+ +  L  QLQE++ ++ +  + 
Sbjct: 1240 ARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA 1299

Query: 167  RDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDL 226
            R E  E     Q EL  +   L + E    ++ +EL +   +L   QE L    +    L
Sbjct: 1300 RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1359

Query: 227  SQKLEELQRHYSTLEEQRDHVIASKTGA------------------ESKITALEQKEQ-- 266
              ++  ++   + L EQ +   A++  A                  E +  ALE  E+  
Sbjct: 1360 GSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEAR 1419

Query: 267  -----ELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLE--KRLEQNLSGEEHV-- 317
                 E +AL Q+L+   + V    + +  +   L +    LE  ++L   L  ++    
Sbjct: 1420 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1479

Query: 318  QELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIV 377
            Q L +EK    + +E+  +     R  +A+A++      R LE+  +A EE  +Q++ + 
Sbjct: 1480 QLLAEEKAAVLRAVEERERAEAEGREREARALSL----TRALEEEQEAREELERQNRALR 1535

Query: 378  AAQETQIQELAAANQESSHVQQQALALEQQFLERTQA----LEAQIVALERTRAADQTTA 433
            A  E  +       + S H  ++A  + +Q     +A    LE ++ A E  +   + T 
Sbjct: 1536 AELEALLSSKDDVGK-SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1594

Query: 434  E----QGMRQLEQENAALKECRNEYERSLQNHQFEL--------------KKLKEEWSQR 475
            +    Q  R L+  + A +E R +  + L++ + E               KKL+ E  + 
Sbjct: 1595 QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEEL 1654

Query: 476  EIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEK--------EQNLREKTEVLLQKEQE 527
            +    +  Q  EE  KQ  + Q Q   L   ++E          QN RE  + L   E E
Sbjct: 1655 KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN-RESEKRLKGLEAE 1713

Query: 528  ILQLER---GHNSALLQIHQLQAEL-EALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSV 583
            +L+L+      + A  Q  Q + E+ + +      +AA++ E+  L    G L+ E   +
Sbjct: 1714 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE---L 1770

Query: 584  NESHVTSRAMQDPVFQLPTAGRTPNGEVGA---------MDLTQLQKEKQDLEQQLLEKN 634
             E    S  + D   +L     +   E+ A             QL+++ Q+L  +L E++
Sbjct: 1771 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEED 1830

Query: 635  --------KTIKQMQQRMLELRKTLQKELKIR 658
                     TI  ++ ++ +  + L++E + R
Sbjct: 1831 AGARARHKMTIAALESKLAQAEEQLEQETRER 1862



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 97/471 (20%), Positives = 200/471 (42%), Gaps = 82/471 (17%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQK-------IKEKLEIALEKHQDSSM 103
            SS++D+   +       R  E   +D   QV  L+         K +LE+ ++  +    
Sbjct: 1543 SSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE 1602

Query: 104  RKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNL 163
            R  Q ++E  +  R ++A+ L  A   +D+E  ++   +   K  L  +L+E+K Q  + 
Sbjct: 1603 RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK-LEGELEELKAQMASA 1661

Query: 164  FQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQ---EELMNSN 220
             Q ++E                       + L KM+ +++   RE+  T+   EE+ + N
Sbjct: 1662 GQGKEEA---------------------VKQLRKMQAQMKELWREVEETRTSREEIFSQN 1700

Query: 221  QMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQ 280
            + S    ++L+ L+     L+E+            +   A  Q +Q+   +  +++    
Sbjct: 1701 RESE---KRLKGLEAEVLRLQEE----------LAASDRARRQAQQDRDEMADEVANGNL 1747

Query: 281  KVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA 340
               A  +EK      L+ ++  LE+ LE+  S  E + +  ++  L    +E    +L A
Sbjct: 1748 SKAAILEEKRQ----LEGRLGQLEEELEEEQSNSELLNDRYRKLLL---QVESLTTELSA 1800

Query: 341  ARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQ-----ELAAANQESS 395
             RS  AKA           E   Q  E Q+Q+ +G +  ++   +      +AA   + +
Sbjct: 1801 ERSFSAKA-----------ESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1849

Query: 396  HVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYE 455
              ++Q   LEQ+  ER       I++ +  R A++   E  + Q+E+E     + R++ E
Sbjct: 1850 QAEEQ---LEQETRER-------ILSGKLVRRAEKRLKEV-VLQVEEERRVADQLRDQLE 1898

Query: 456  RS---LQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANL 503
            +    ++  + +L++ +EE S+ +     + + LE+V +  E   ++   L
Sbjct: 1899 KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL 1949



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 55/298 (18%), Positives = 125/298 (41%), Gaps = 34/298 (11%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDS------SMR 104
            +SRE++ SQ     ++++ LEA +    E++    + + + +   ++  D       S  
Sbjct: 1691 TSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA 1750

Query: 105  KFQEQNETFQANRAKMAEGLALALARKDQEWSEKMD----QLEKEKNILTAQLQEMKNQS 160
               E+    +    ++ E L      ++Q  SE ++    +L  +   LT +L   ++ S
Sbjct: 1751 AILEEKRQLEGRLGQLEEEL-----EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1805

Query: 161  MNLFQRRDEMD----ELEGFQQQE----LSKIKHMLLKKEESLGKMEQELEARTRELSRT 212
                  R +++    EL G   +E     ++ K  +   E  L + E++LE  TRE   +
Sbjct: 1806 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILS 1865

Query: 213  QEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALI 272
             + +  + +   ++  ++EE +R    L +Q +         + ++   E++    QA  
Sbjct: 1866 GKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGR 1925

Query: 273  QQLSIDLQKVTAETQEKEDVITHLQEKV-----------ASLEKRLEQNLSGEEHVQE 319
            ++L  +L+ VT   +     +T L+ ++                RLE+ ++ +E  +E
Sbjct: 1926 RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1983


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  115 bits (287), Expect = 2e-25
 Identities = 164/668 (24%), Positives = 295/668 (44%), Gaps = 116/668 (17%)

Query: 55   DLSSQLLRRNEQIRKL-------EARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQ 107
            + SSQ     E+++ L       EA ++D  +++R  +K +++LE  L++  D    + Q
Sbjct: 1027 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE-KLKRRLDGESSELQ 1085

Query: 108  EQN-------ETFQANRAKMAEGLALALARKDQEWSEKMDQLE--KEKNILTAQLQE-MK 157
            EQ        E  +A   +  E L  ALAR + E   +   L+  +E     A+ QE ++
Sbjct: 1086 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLE 1145

Query: 158  NQSMNLF----QRRDEMDELEGFQQQ------ELSKIKHMLLKKEESLGKMEQELEARTR 207
            ++ +       QRRD  +ELE  + +        +  + +  K+E+ + ++++ LE  TR
Sbjct: 1146 SERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1205

Query: 208  ELSRTQEELMNSN-QMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQ 266
                  +EL   + Q   +L+++LE+ +R     E+ R  + A  +   +++++L+   Q
Sbjct: 1206 IHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1265

Query: 267  ELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSG-----EEHVQELL 321
            E +   ++L + LQ+V     + E       EK+   +  LE N+SG     E     L 
Sbjct: 1266 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-NVSGALNEAESKTIRLS 1324

Query: 322  KEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQE 381
            KE +  E  L D ++ L      + +A   L +RVR +E       EQL++     AA+E
Sbjct: 1325 KELSSTEAQLHDAQELL----QEETRAKLALGSRVRAMEAEAAGLREQLEEE---AAARE 1377

Query: 382  TQIQELAAANQESSH---------------------VQQQALALEQQFLERTQALEAQIV 420
               +EL  A  + S                        ++A AL Q+  E+T+ ++    
Sbjct: 1378 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDR--- 1434

Query: 421  ALERTRAADQTTAEQGMRQLEQEN---AALKECRNEYERSLQNHQF-------ELKKLKE 470
             LER R   Q   +     LEQ+    + L++ + ++++ L   +        E ++ + 
Sbjct: 1435 -LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1493

Query: 471  EWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQ 530
            E  +RE  ++++ +ALEE ++ REE ++Q   L A   E E  L  K +V     + + +
Sbjct: 1494 EGREREARALSLTRALEEEQEAREELERQNRALRA---ELEALLSSKDDV----GKSVHE 1546

Query: 531  LERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTS 590
            LER    A    + L+A++  L      E  + A ++  LRL   +QA    +   H   
Sbjct: 1547 LERACRVAEQAANDLRAQVTEL------EDELTAAEDAKLRLEVTVQA----LKTQH--E 1594

Query: 591  RAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLEL--R 648
            R +Q         GR    E G     QL K+ +D E +  E+ K      QR L +  R
Sbjct: 1595 RDLQ---------GR---DEAGEERRRQLAKQLRDAEVERDEERK------QRTLAVAAR 1636

Query: 649  KTLQKELK 656
            K L+ EL+
Sbjct: 1637 KKLEGELE 1644



 Score =  111 bits (277), Expect = 3e-24
 Identities = 138/650 (21%), Positives = 288/650 (44%), Gaps = 61/650 (9%)

Query: 44   DFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEI---ALEKH-- 98
            +  ++   +R  L+++       + +LEAR+ +  E  R +Q  K++L+     LE H  
Sbjct: 918  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 977

Query: 99   -QDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMK 157
             ++ + +K Q +  T +A   K  E L L          ++  +L KE+ +L  +L E  
Sbjct: 978  AEEGARQKLQLEKVTTEAKMKKFEEDLLLL--------EDQNSKLSKERKLLEDRLAEFS 1029

Query: 158  NQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE---ESLGKMEQELEARTRELSRTQ- 213
            +Q+    ++   +++L    +  ++ ++  L K+E   + L K+++ L+  + EL     
Sbjct: 1030 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1089

Query: 214  EELMNSNQMSSDLSQKLEELQRHYSTLEEQ---RDHVIASKTGAESKI------------ 258
            E+   + ++ + L +K EELQ   +  E++   R  ++ S   A++ +            
Sbjct: 1090 EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1149

Query: 259  --TALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLS-GEE 315
              T  E++ ++L   ++ L  +L+     T  ++++ +  +++V  L+K LE+     E 
Sbjct: 1150 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1209

Query: 316  HVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELE---QTLQASEEQLQQ 372
             VQEL +    A   L +  +Q    + +  K    LE  V EL     +LQ + ++ +Q
Sbjct: 1210 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1269

Query: 373  SKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQAL--EAQIVALERTRAADQ 430
             +  +  Q  ++Q  A   + +     + L   Q  LE       EA+   +  ++    
Sbjct: 1270 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1329

Query: 431  TTAE-QGMRQLEQENAALKECRNEYERSLQNHQFELK-KLKEEWSQREIVSVAMAQALEE 488
            T A+    ++L QE    K       R+++     L+ +L+EE + RE     +  A  +
Sbjct: 1330 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1389

Query: 489  VRKQREEFQQQAANLTAIIDEKEQNLREK---TEVLLQKEQEILQLERGHNSALLQIHQL 545
            + + R   +++A  L A  + + +  RE    T+ L +K + + +LERG         +L
Sbjct: 1390 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR-------RRL 1442

Query: 546  QAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGR 605
            Q EL+       ++  +V+  E   R    L AE     E     RA+++   +    GR
Sbjct: 1443 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE-----EKAAVLRAVEERE-RAEAEGR 1496

Query: 606  TPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKEL 655
                E  A+ LT+  +E+Q+  ++L  +N+ ++   + +L  +  + K +
Sbjct: 1497 --EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSV 1544



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 156/675 (23%), Positives = 281/675 (41%), Gaps = 128/675 (18%)

Query: 3    AKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLR 62
            A+  +K+    A  +   GA  +  + SK    S    S +    D     ++ +   L 
Sbjct: 1293 AEAAEKLQRAQAELENVSGA--LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1350

Query: 63   RNEQIRKLEARLSDYAEQVRNLQKIKEKL--EIALEKHQDSSMRKFQEQN-------ETF 113
               ++R +EA  +   EQ+      +E+   E+   + Q S  R+ QE+        E  
Sbjct: 1351 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1410

Query: 114  QANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDEL 173
            +   A+ AE L   LA K    +E +D+LE+ +  L    QE+ + +M+L Q+R  +  L
Sbjct: 1411 RRRAAREAEALTQRLAEK----TETVDRLERGRRRLQ---QELDDATMDLEQQRQLVSTL 1463

Query: 174  EGFQQ---QELSKIKHMLLKKEESLGKME---QELEARTRELSRTQEELMNSNQMSSDLS 227
            E  Q+   Q L++ K  +L+  E   + E   +E EAR   L+R  EE   +        
Sbjct: 1464 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR------- 1516

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
               EEL+R    L  + + +++SK      +  LE+  +  +     L   + ++  E  
Sbjct: 1517 ---EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1573

Query: 288  EKEDVITHLQEKVASLEKRLEQNL-----SGEEHVQELLKEKTLAEQNLEDTRQQLLAAR 342
              ED    L+  V +L+ + E++L     +GEE  ++L K+   AE   ++ R+Q   A 
Sbjct: 1574 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1633

Query: 343  SSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQAL 402
            +++ K    LE    ++    Q  EE ++Q + + A    Q++EL    +E+   +++  
Sbjct: 1634 AARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA----QMKELWREVEETRTSREEIF 1689

Query: 403  ALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQ-----ENAAL-KECRNEYER 456
            +  ++  +R + LEA+++ L+   AA      Q  +  ++      N  L K    E +R
Sbjct: 1690 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1749

Query: 457  SLQNHQFELKK-LKEEWSQREIVSVAMAQALEEVRKQ-----------------REEFQQ 498
             L+    +L++ L+EE S  E+++    + L +V                    R++ ++
Sbjct: 1750 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1809

Query: 499  QAANLTAIIDEK--------------------------EQNLREKT-------------- 518
            Q   L   + E+                          EQ  RE+               
Sbjct: 1810 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1869

Query: 519  EVLLQKEQEIL-------QLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLR 571
            EV+LQ E+E         QLE+G+    L++ QL+ +LE     +AEE A  A+      
Sbjct: 1870 EVVLQVEEERRVADQLRDQLEKGN----LRVKQLKRQLE-----EAEEEASRAQAG---- 1916

Query: 572  LRGPLQAEALSVNES 586
             R  LQ E   V ES
Sbjct: 1917 -RRRLQRELEDVTES 1930



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 121/574 (21%), Positives = 253/574 (44%), Gaps = 75/574 (13%)

Query: 141  QLEKEKN------ILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELS---KIKHM---- 187
            QLE+E++      I++ Q       +   FQ+R +        Q+  +   K++H     
Sbjct: 794  QLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWR 853

Query: 188  LLKKEESL---GKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQR 244
            L  K + L    + ++ L+AR +EL + QE       +    ++++ ELQ   + LEE+R
Sbjct: 854  LFTKVKPLLQVTRQDEVLQARAQELQKVQE-------LQQQSAREVGELQGRVAQLEEER 906

Query: 245  DHVIASKTGAESKITA-LEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASL 303
               +A +  AE+++ A  E+    L A  Q+L + + ++ A   E+E+    +Q +   L
Sbjct: 907  AR-LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRL 965

Query: 304  E---KRLEQNLSGEEHV-QELLKEKTLAEQNLEDTRQQLLA---ARSSQAKAINTLETRV 356
            +   + LE +L  EE   Q+L  EK   E  ++   + LL      S  +K    LE R+
Sbjct: 966  QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1025

Query: 357  RELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALE 416
             E        EE+++    +    E  I ++    ++    +Q+   L+++    +  L+
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1085

Query: 417  AQIVALERTRAADQTTAEQGMRQLEQENAALKE-----CRNEYERSLQNHQFELKKLKEE 471
             Q+V  E+ + A++  A+ G ++ E + A  +       R +  +SL+  Q  L + +E+
Sbjct: 1086 EQMV--EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1143

Query: 472  WSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQL 531
                 +       A  +  KQR +  ++   L   +++   +   + E+  ++EQE+ +L
Sbjct: 1144 LESERV-------ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTEL 1196

Query: 532  E-------RGHNSALLQIHQ--------LQAELEALRTLK-AEEAAVVAEQEDLLRLRGP 575
            +       R H +A+ ++ Q        L  +LE  R  K A E   +A + ++  LR  
Sbjct: 1197 KKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAE 1256

Query: 576  LQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQ-LQKEKQDL-------- 626
            L +   +  E     R ++  + ++   GR  +GE    +  + LQ+ + +L        
Sbjct: 1257 LSSLQTARQEGEQRRRRLELQLQEV--QGRAGDGERARAEAAEKLQRAQAELENVSGALN 1314

Query: 627  --EQQLLEKNKTIKQMQQRMLELRKTLQKELKIR 658
              E + +  +K +   + ++ + ++ LQ+E + +
Sbjct: 1315 EAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1348



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 161/752 (21%), Positives = 309/752 (41%), Gaps = 117/752 (15%)

Query: 3    AKLKKKIAEETAV---AQRPGGATRIPRSVSKESVASMGAD----SGD-DFASDGSSSRE 54
            A+L K + E  A    AQ    + R+ R+ +++    +G +     G+ +   D +++++
Sbjct: 1124 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1183

Query: 55   DLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQ 114
            +L S   +R +++ +L+  L +         +I E     L +    ++ +  EQ E  Q
Sbjct: 1184 ELRS---KREQEVTELKKTLEEET-------RIHEAAVQELRQRHGQALGELAEQLE--Q 1231

Query: 115  ANRAKMA-EGLALALARKDQEWSEKMDQL-------EKEKNILTAQLQEMKNQSMNLFQR 166
            A R K A E   LAL  +  E   ++  L       E+ +  L  QLQE++ ++ +  + 
Sbjct: 1232 ARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA 1291

Query: 167  RDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDL 226
            R E  E     Q EL  +   L + E    ++ +EL +   +L   QE L    +    L
Sbjct: 1292 RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1351

Query: 227  SQKLEELQRHYSTLEEQRDHVIASKTGA------------------ESKITALEQKEQ-- 266
              ++  ++   + L EQ +   A++  A                  E +  ALE  E+  
Sbjct: 1352 GSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEAR 1411

Query: 267  -----ELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLE--KRLEQNLSGEEHV-- 317
                 E +AL Q+L+   + V    + +  +   L +    LE  ++L   L  ++    
Sbjct: 1412 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1471

Query: 318  QELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIV 377
            Q L +EK    + +E+  +     R  +A+A++      R LE+  +A EE  +Q++ + 
Sbjct: 1472 QLLAEEKAAVLRAVEERERAEAEGREREARALSL----TRALEEEQEAREELERQNRALR 1527

Query: 378  AAQETQIQELAAANQESSHVQQQALALEQQFLERTQA----LEAQIVALERTRAADQTTA 433
            A  E  +       + S H  ++A  + +Q     +A    LE ++ A E  +   + T 
Sbjct: 1528 AELEALLSSKDDVGK-SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1586

Query: 434  E----QGMRQLEQENAALKECRNEYERSLQNHQFEL--------------KKLKEEWSQR 475
            +    Q  R L+  + A +E R +  + L++ + E               KKL+ E  + 
Sbjct: 1587 QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEEL 1646

Query: 476  EIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEK--------EQNLREKTEVLLQKEQE 527
            +    +  Q  EE  KQ  + Q Q   L   ++E          QN RE  + L   E E
Sbjct: 1647 KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN-RESEKRLKGLEAE 1705

Query: 528  ILQLER---GHNSALLQIHQLQAEL-EALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSV 583
            +L+L+      + A  Q  Q + E+ + +      +AA++ E+  L    G L+ E   +
Sbjct: 1706 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE---L 1762

Query: 584  NESHVTSRAMQDPVFQLPTAGRTPNGEVGA---------MDLTQLQKEKQDLEQQLLEKN 634
             E    S  + D   +L     +   E+ A             QL+++ Q+L  +L E++
Sbjct: 1763 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEED 1822

Query: 635  --------KTIKQMQQRMLELRKTLQKELKIR 658
                     TI  ++ ++ +  + L++E + R
Sbjct: 1823 AGARARHKMTIAALESKLAQAEEQLEQETRER 1854



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 97/471 (20%), Positives = 200/471 (42%), Gaps = 82/471 (17%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQK-------IKEKLEIALEKHQDSSM 103
            SS++D+   +       R  E   +D   QV  L+         K +LE+ ++  +    
Sbjct: 1535 SSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE 1594

Query: 104  RKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNL 163
            R  Q ++E  +  R ++A+ L  A   +D+E  ++   +   K  L  +L+E+K Q  + 
Sbjct: 1595 RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK-LEGELEELKAQMASA 1653

Query: 164  FQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQ---EELMNSN 220
             Q ++E                       + L KM+ +++   RE+  T+   EE+ + N
Sbjct: 1654 GQGKEEA---------------------VKQLRKMQAQMKELWREVEETRTSREEIFSQN 1692

Query: 221  QMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQ 280
            + S    ++L+ L+     L+E+            +   A  Q +Q+   +  +++    
Sbjct: 1693 RESE---KRLKGLEAEVLRLQEE----------LAASDRARRQAQQDRDEMADEVANGNL 1739

Query: 281  KVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA 340
               A  +EK      L+ ++  LE+ LE+  S  E + +  ++  L    +E    +L A
Sbjct: 1740 SKAAILEEKRQ----LEGRLGQLEEELEEEQSNSELLNDRYRKLLL---QVESLTTELSA 1792

Query: 341  ARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQ-----ELAAANQESS 395
             RS  AKA           E   Q  E Q+Q+ +G +  ++   +      +AA   + +
Sbjct: 1793 ERSFSAKA-----------ESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1841

Query: 396  HVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYE 455
              ++Q   LEQ+  ER       I++ +  R A++   E  + Q+E+E     + R++ E
Sbjct: 1842 QAEEQ---LEQETRER-------ILSGKLVRRAEKRLKEV-VLQVEEERRVADQLRDQLE 1890

Query: 456  RS---LQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANL 503
            +    ++  + +L++ +EE S+ +     + + LE+V +  E   ++   L
Sbjct: 1891 KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL 1941



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 55/298 (18%), Positives = 125/298 (41%), Gaps = 34/298 (11%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDS------SMR 104
            +SRE++ SQ     ++++ LEA +    E++    + + + +   ++  D       S  
Sbjct: 1683 TSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA 1742

Query: 105  KFQEQNETFQANRAKMAEGLALALARKDQEWSEKMD----QLEKEKNILTAQLQEMKNQS 160
               E+    +    ++ E L      ++Q  SE ++    +L  +   LT +L   ++ S
Sbjct: 1743 AILEEKRQLEGRLGQLEEEL-----EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1797

Query: 161  MNLFQRRDEMD----ELEGFQQQE----LSKIKHMLLKKEESLGKMEQELEARTRELSRT 212
                  R +++    EL G   +E     ++ K  +   E  L + E++LE  TRE   +
Sbjct: 1798 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILS 1857

Query: 213  QEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALI 272
             + +  + +   ++  ++EE +R    L +Q +         + ++   E++    QA  
Sbjct: 1858 GKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGR 1917

Query: 273  QQLSIDLQKVTAETQEKEDVITHLQEKV-----------ASLEKRLEQNLSGEEHVQE 319
            ++L  +L+ VT   +     +T L+ ++                RLE+ ++ +E  +E
Sbjct: 1918 RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1975


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score =  115 bits (287), Expect = 2e-25
 Identities = 164/668 (24%), Positives = 295/668 (44%), Gaps = 116/668 (17%)

Query: 55   DLSSQLLRRNEQIRKL-------EARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQ 107
            + SSQ     E+++ L       EA ++D  +++R  +K +++LE  L++  D    + Q
Sbjct: 1068 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE-KLKRRLDGESSELQ 1126

Query: 108  EQN-------ETFQANRAKMAEGLALALARKDQEWSEKMDQLE--KEKNILTAQLQE-MK 157
            EQ        E  +A   +  E L  ALAR + E   +   L+  +E     A+ QE ++
Sbjct: 1127 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLE 1186

Query: 158  NQSMNLF----QRRDEMDELEGFQQQ------ELSKIKHMLLKKEESLGKMEQELEARTR 207
            ++ +       QRRD  +ELE  + +        +  + +  K+E+ + ++++ LE  TR
Sbjct: 1187 SERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1246

Query: 208  ELSRTQEELMNSN-QMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQ 266
                  +EL   + Q   +L+++LE+ +R     E+ R  + A  +   +++++L+   Q
Sbjct: 1247 IHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1306

Query: 267  ELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSG-----EEHVQELL 321
            E +   ++L + LQ+V     + E       EK+   +  LE N+SG     E     L 
Sbjct: 1307 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-NVSGALNEAESKTIRLS 1365

Query: 322  KEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQE 381
            KE +  E  L D ++ L      + +A   L +RVR +E       EQL++     AA+E
Sbjct: 1366 KELSSTEAQLHDAQELL----QEETRAKLALGSRVRAMEAEAAGLREQLEEE---AAARE 1418

Query: 382  TQIQELAAANQESSH---------------------VQQQALALEQQFLERTQALEAQIV 420
               +EL  A  + S                        ++A AL Q+  E+T+ ++    
Sbjct: 1419 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDR--- 1475

Query: 421  ALERTRAADQTTAEQGMRQLEQEN---AALKECRNEYERSLQNHQF-------ELKKLKE 470
             LER R   Q   +     LEQ+    + L++ + ++++ L   +        E ++ + 
Sbjct: 1476 -LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1534

Query: 471  EWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQ 530
            E  +RE  ++++ +ALEE ++ REE ++Q   L A   E E  L  K +V     + + +
Sbjct: 1535 EGREREARALSLTRALEEEQEAREELERQNRALRA---ELEALLSSKDDV----GKSVHE 1587

Query: 531  LERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTS 590
            LER    A    + L+A++  L      E  + A ++  LRL   +QA    +   H   
Sbjct: 1588 LERACRVAEQAANDLRAQVTEL------EDELTAAEDAKLRLEVTVQA----LKTQH--E 1635

Query: 591  RAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLEL--R 648
            R +Q         GR    E G     QL K+ +D E +  E+ K      QR L +  R
Sbjct: 1636 RDLQ---------GR---DEAGEERRRQLAKQLRDAEVERDEERK------QRTLAVAAR 1677

Query: 649  KTLQKELK 656
            K L+ EL+
Sbjct: 1678 KKLEGELE 1685



 Score =  111 bits (277), Expect = 3e-24
 Identities = 138/650 (21%), Positives = 288/650 (44%), Gaps = 61/650 (9%)

Query: 44   DFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEI---ALEKH-- 98
            +  ++   +R  L+++       + +LEAR+ +  E  R +Q  K++L+     LE H  
Sbjct: 959  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 1018

Query: 99   -QDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMK 157
             ++ + +K Q +  T +A   K  E L L          ++  +L KE+ +L  +L E  
Sbjct: 1019 AEEGARQKLQLEKVTTEAKMKKFEEDLLLL--------EDQNSKLSKERKLLEDRLAEFS 1070

Query: 158  NQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE---ESLGKMEQELEARTRELSRTQ- 213
            +Q+    ++   +++L    +  ++ ++  L K+E   + L K+++ L+  + EL     
Sbjct: 1071 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1130

Query: 214  EELMNSNQMSSDLSQKLEELQRHYSTLEEQ---RDHVIASKTGAESKI------------ 258
            E+   + ++ + L +K EELQ   +  E++   R  ++ S   A++ +            
Sbjct: 1131 EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1190

Query: 259  --TALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLS-GEE 315
              T  E++ ++L   ++ L  +L+     T  ++++ +  +++V  L+K LE+     E 
Sbjct: 1191 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1250

Query: 316  HVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELE---QTLQASEEQLQQ 372
             VQEL +    A   L +  +Q    + +  K    LE  V EL     +LQ + ++ +Q
Sbjct: 1251 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1310

Query: 373  SKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQAL--EAQIVALERTRAADQ 430
             +  +  Q  ++Q  A   + +     + L   Q  LE       EA+   +  ++    
Sbjct: 1311 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1370

Query: 431  TTAE-QGMRQLEQENAALKECRNEYERSLQNHQFELK-KLKEEWSQREIVSVAMAQALEE 488
            T A+    ++L QE    K       R+++     L+ +L+EE + RE     +  A  +
Sbjct: 1371 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1430

Query: 489  VRKQREEFQQQAANLTAIIDEKEQNLREK---TEVLLQKEQEILQLERGHNSALLQIHQL 545
            + + R   +++A  L A  + + +  RE    T+ L +K + + +LERG         +L
Sbjct: 1431 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR-------RRL 1483

Query: 546  QAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGR 605
            Q EL+       ++  +V+  E   R    L AE     E     RA+++   +    GR
Sbjct: 1484 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE-----EKAAVLRAVEERE-RAEAEGR 1537

Query: 606  TPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKEL 655
                E  A+ LT+  +E+Q+  ++L  +N+ ++   + +L  +  + K +
Sbjct: 1538 --EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSV 1585



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 156/675 (23%), Positives = 281/675 (41%), Gaps = 128/675 (18%)

Query: 3    AKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLR 62
            A+  +K+    A  +   GA  +  + SK    S    S +    D     ++ +   L 
Sbjct: 1334 AEAAEKLQRAQAELENVSGA--LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1391

Query: 63   RNEQIRKLEARLSDYAEQVRNLQKIKEKL--EIALEKHQDSSMRKFQEQN-------ETF 113
               ++R +EA  +   EQ+      +E+   E+   + Q S  R+ QE+        E  
Sbjct: 1392 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1451

Query: 114  QANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDEL 173
            +   A+ AE L   LA K    +E +D+LE+ +  L    QE+ + +M+L Q+R  +  L
Sbjct: 1452 RRRAAREAEALTQRLAEK----TETVDRLERGRRRLQ---QELDDATMDLEQQRQLVSTL 1504

Query: 174  EGFQQ---QELSKIKHMLLKKEESLGKME---QELEARTRELSRTQEELMNSNQMSSDLS 227
            E  Q+   Q L++ K  +L+  E   + E   +E EAR   L+R  EE   +        
Sbjct: 1505 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR------- 1557

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
               EEL+R    L  + + +++SK      +  LE+  +  +     L   + ++  E  
Sbjct: 1558 ---EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1614

Query: 288  EKEDVITHLQEKVASLEKRLEQNL-----SGEEHVQELLKEKTLAEQNLEDTRQQLLAAR 342
              ED    L+  V +L+ + E++L     +GEE  ++L K+   AE   ++ R+Q   A 
Sbjct: 1615 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1674

Query: 343  SSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQAL 402
            +++ K    LE    ++    Q  EE ++Q + + A    Q++EL    +E+   +++  
Sbjct: 1675 AARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA----QMKELWREVEETRTSREEIF 1730

Query: 403  ALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQ-----ENAAL-KECRNEYER 456
            +  ++  +R + LEA+++ L+   AA      Q  +  ++      N  L K    E +R
Sbjct: 1731 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1790

Query: 457  SLQNHQFELKK-LKEEWSQREIVSVAMAQALEEVRKQ-----------------REEFQQ 498
             L+    +L++ L+EE S  E+++    + L +V                    R++ ++
Sbjct: 1791 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1850

Query: 499  QAANLTAIIDEK--------------------------EQNLREKT-------------- 518
            Q   L   + E+                          EQ  RE+               
Sbjct: 1851 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1910

Query: 519  EVLLQKEQEIL-------QLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLR 571
            EV+LQ E+E         QLE+G+    L++ QL+ +LE     +AEE A  A+      
Sbjct: 1911 EVVLQVEEERRVADQLRDQLEKGN----LRVKQLKRQLE-----EAEEEASRAQAG---- 1957

Query: 572  LRGPLQAEALSVNES 586
             R  LQ E   V ES
Sbjct: 1958 -RRRLQRELEDVTES 1971



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 121/574 (21%), Positives = 253/574 (44%), Gaps = 75/574 (13%)

Query: 141  QLEKEKN------ILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELS---KIKHM---- 187
            QLE+E++      I++ Q       +   FQ+R +        Q+  +   K++H     
Sbjct: 835  QLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWR 894

Query: 188  LLKKEESL---GKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQR 244
            L  K + L    + ++ L+AR +EL + QE       +    ++++ ELQ   + LEE+R
Sbjct: 895  LFTKVKPLLQVTRQDEVLQARAQELQKVQE-------LQQQSAREVGELQGRVAQLEEER 947

Query: 245  DHVIASKTGAESKITA-LEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASL 303
               +A +  AE+++ A  E+    L A  Q+L + + ++ A   E+E+    +Q +   L
Sbjct: 948  AR-LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRL 1006

Query: 304  E---KRLEQNLSGEEHV-QELLKEKTLAEQNLEDTRQQLLA---ARSSQAKAINTLETRV 356
            +   + LE +L  EE   Q+L  EK   E  ++   + LL      S  +K    LE R+
Sbjct: 1007 QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1066

Query: 357  RELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALE 416
             E        EE+++    +    E  I ++    ++    +Q+   L+++    +  L+
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1126

Query: 417  AQIVALERTRAADQTTAEQGMRQLEQENAALKE-----CRNEYERSLQNHQFELKKLKEE 471
             Q+V  E+ + A++  A+ G ++ E + A  +       R +  +SL+  Q  L + +E+
Sbjct: 1127 EQMV--EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1184

Query: 472  WSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQL 531
                 +       A  +  KQR +  ++   L   +++   +   + E+  ++EQE+ +L
Sbjct: 1185 LESERV-------ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTEL 1237

Query: 532  E-------RGHNSALLQIHQ--------LQAELEALRTLK-AEEAAVVAEQEDLLRLRGP 575
            +       R H +A+ ++ Q        L  +LE  R  K A E   +A + ++  LR  
Sbjct: 1238 KKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAE 1297

Query: 576  LQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQ-LQKEKQDL-------- 626
            L +   +  E     R ++  + ++   GR  +GE    +  + LQ+ + +L        
Sbjct: 1298 LSSLQTARQEGEQRRRRLELQLQEV--QGRAGDGERARAEAAEKLQRAQAELENVSGALN 1355

Query: 627  --EQQLLEKNKTIKQMQQRMLELRKTLQKELKIR 658
              E + +  +K +   + ++ + ++ LQ+E + +
Sbjct: 1356 EAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1389



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 161/752 (21%), Positives = 309/752 (41%), Gaps = 117/752 (15%)

Query: 3    AKLKKKIAEETAV---AQRPGGATRIPRSVSKESVASMGAD----SGD-DFASDGSSSRE 54
            A+L K + E  A    AQ    + R+ R+ +++    +G +     G+ +   D +++++
Sbjct: 1165 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1224

Query: 55   DLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQ 114
            +L S   +R +++ +L+  L +         +I E     L +    ++ +  EQ E  Q
Sbjct: 1225 ELRS---KREQEVTELKKTLEEET-------RIHEAAVQELRQRHGQALGELAEQLE--Q 1272

Query: 115  ANRAKMA-EGLALALARKDQEWSEKMDQL-------EKEKNILTAQLQEMKNQSMNLFQR 166
            A R K A E   LAL  +  E   ++  L       E+ +  L  QLQE++ ++ +  + 
Sbjct: 1273 ARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA 1332

Query: 167  RDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDL 226
            R E  E     Q EL  +   L + E    ++ +EL +   +L   QE L    +    L
Sbjct: 1333 RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1392

Query: 227  SQKLEELQRHYSTLEEQRDHVIASKTGA------------------ESKITALEQKEQ-- 266
              ++  ++   + L EQ +   A++  A                  E +  ALE  E+  
Sbjct: 1393 GSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEAR 1452

Query: 267  -----ELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLE--KRLEQNLSGEEHV-- 317
                 E +AL Q+L+   + V    + +  +   L +    LE  ++L   L  ++    
Sbjct: 1453 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1512

Query: 318  QELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIV 377
            Q L +EK    + +E+  +     R  +A+A++      R LE+  +A EE  +Q++ + 
Sbjct: 1513 QLLAEEKAAVLRAVEERERAEAEGREREARALSL----TRALEEEQEAREELERQNRALR 1568

Query: 378  AAQETQIQELAAANQESSHVQQQALALEQQFLERTQA----LEAQIVALERTRAADQTTA 433
            A  E  +       + S H  ++A  + +Q     +A    LE ++ A E  +   + T 
Sbjct: 1569 AELEALLSSKDDVGK-SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1627

Query: 434  E----QGMRQLEQENAALKECRNEYERSLQNHQFEL--------------KKLKEEWSQR 475
            +    Q  R L+  + A +E R +  + L++ + E               KKL+ E  + 
Sbjct: 1628 QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEEL 1687

Query: 476  EIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEK--------EQNLREKTEVLLQKEQE 527
            +    +  Q  EE  KQ  + Q Q   L   ++E          QN RE  + L   E E
Sbjct: 1688 KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN-RESEKRLKGLEAE 1746

Query: 528  ILQLER---GHNSALLQIHQLQAEL-EALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSV 583
            +L+L+      + A  Q  Q + E+ + +      +AA++ E+  L    G L+ E   +
Sbjct: 1747 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE---L 1803

Query: 584  NESHVTSRAMQDPVFQLPTAGRTPNGEVGA---------MDLTQLQKEKQDLEQQLLEKN 634
             E    S  + D   +L     +   E+ A             QL+++ Q+L  +L E++
Sbjct: 1804 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEED 1863

Query: 635  --------KTIKQMQQRMLELRKTLQKELKIR 658
                     TI  ++ ++ +  + L++E + R
Sbjct: 1864 AGARARHKMTIAALESKLAQAEEQLEQETRER 1895



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 97/471 (20%), Positives = 200/471 (42%), Gaps = 82/471 (17%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQK-------IKEKLEIALEKHQDSSM 103
            SS++D+   +       R  E   +D   QV  L+         K +LE+ ++  +    
Sbjct: 1576 SSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE 1635

Query: 104  RKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNL 163
            R  Q ++E  +  R ++A+ L  A   +D+E  ++   +   K  L  +L+E+K Q  + 
Sbjct: 1636 RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK-LEGELEELKAQMASA 1694

Query: 164  FQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQ---EELMNSN 220
             Q ++E                       + L KM+ +++   RE+  T+   EE+ + N
Sbjct: 1695 GQGKEEA---------------------VKQLRKMQAQMKELWREVEETRTSREEIFSQN 1733

Query: 221  QMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQ 280
            + S    ++L+ L+     L+E+            +   A  Q +Q+   +  +++    
Sbjct: 1734 RESE---KRLKGLEAEVLRLQEE----------LAASDRARRQAQQDRDEMADEVANGNL 1780

Query: 281  KVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLA 340
               A  +EK      L+ ++  LE+ LE+  S  E + +  ++  L    +E    +L A
Sbjct: 1781 SKAAILEEKRQ----LEGRLGQLEEELEEEQSNSELLNDRYRKLLL---QVESLTTELSA 1833

Query: 341  ARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQ-----ELAAANQESS 395
             RS  AKA           E   Q  E Q+Q+ +G +  ++   +      +AA   + +
Sbjct: 1834 ERSFSAKA-----------ESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLA 1882

Query: 396  HVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYE 455
              ++Q   LEQ+  ER       I++ +  R A++   E  + Q+E+E     + R++ E
Sbjct: 1883 QAEEQ---LEQETRER-------ILSGKLVRRAEKRLKEV-VLQVEEERRVADQLRDQLE 1931

Query: 456  RS---LQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANL 503
            +    ++  + +L++ +EE S+ +     + + LE+V +  E   ++   L
Sbjct: 1932 KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL 1982



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 55/298 (18%), Positives = 125/298 (41%), Gaps = 34/298 (11%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDS------SMR 104
            +SRE++ SQ     ++++ LEA +    E++    + + + +   ++  D       S  
Sbjct: 1724 TSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA 1783

Query: 105  KFQEQNETFQANRAKMAEGLALALARKDQEWSEKMD----QLEKEKNILTAQLQEMKNQS 160
               E+    +    ++ E L      ++Q  SE ++    +L  +   LT +L   ++ S
Sbjct: 1784 AILEEKRQLEGRLGQLEEEL-----EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1838

Query: 161  MNLFQRRDEMD----ELEGFQQQE----LSKIKHMLLKKEESLGKMEQELEARTRELSRT 212
                  R +++    EL G   +E     ++ K  +   E  L + E++LE  TRE   +
Sbjct: 1839 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILS 1898

Query: 213  QEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALI 272
             + +  + +   ++  ++EE +R    L +Q +         + ++   E++    QA  
Sbjct: 1899 GKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGR 1958

Query: 273  QQLSIDLQKVTAETQEKEDVITHLQEKV-----------ASLEKRLEQNLSGEEHVQE 319
            ++L  +L+ VT   +     +T L+ ++                RLE+ ++ +E  +E
Sbjct: 1959 RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 2016


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score =  114 bits (286), Expect = 3e-25
 Identities = 147/653 (22%), Positives = 283/653 (43%), Gaps = 111/653 (16%)

Query: 50   SSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKE--KLEIALEKHQ-DSSMRKF 106
            + S+ ++  + ++++E ++ L+ ++S+   +VR L    E  K E+ L  +Q + +  KF
Sbjct: 813  TESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKF 872

Query: 107  QEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNL--- 163
            ++Q                  L +K    SE++  L+KE  I    LQE   Q++ L   
Sbjct: 873  EKQ------------------LKKK----SEEVYCLQKELKIKNHSLQETSEQNVILQHT 910

Query: 164  FQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEAR---TRELSRTQEELMNSN 220
             Q++ +M + E  +  EL   +    K E+ + K+EQEL+ +   + E  R  EE   S 
Sbjct: 911  LQQQQQMLQQETIRNGELEDTQ---TKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESA 967

Query: 221  QMSSDLS-QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDL 279
               +DL  QK+ EL      ++ + D      +  E +I  L++  +     + QL + L
Sbjct: 968  AHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMIL 1027

Query: 280  QKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLL 339
             +   E ++K + +  L++   S E  L + L   E ++  L+    A   L+ T +QL 
Sbjct: 1028 DQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQN---AHGELKSTLRQLQ 1084

Query: 340  AARSSQAKAINTLE---TRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSH 396
              R    KA  +LE   T +++L   L+  + +++  K  +   +  ++E    N E   
Sbjct: 1085 ELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKE---RNWELKQ 1141

Query: 397  VQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYER 456
               Q   L+    E    +E +I+ LE T              LE+    LKEC  + E 
Sbjct: 1142 RAAQVTHLDMTIREHRGEMEQKIIKLEGT--------------LEKSELELKECNKQIE- 1186

Query: 457  SLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLRE 516
            SL +   +L+  KE+  ++E + +   Q + +++K+ E  QQ+   + +++ E+EQ +  
Sbjct: 1187 SLND---KLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT 1243

Query: 517  K--------TEVLLQKEQ------EILQLERGHNSALLQIHQLQAELEALRTLKAE---- 558
            +         E+ L +EQ      E+ +       A  +I +L +ELE ++ L  E    
Sbjct: 1244 QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAH 1303

Query: 559  ------------------EAAVVAE----QEDLLRLRGPLQAEALSVNESH----VTSRA 592
                              EA + AE      ++  L+     E +S  E+H    +++ +
Sbjct: 1304 GNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADS 1363

Query: 593  MQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRML 645
             +  V QL         E   ++L + Q    +L QQ+ ++N+ I+   + +L
Sbjct: 1364 QKSSVQQL-----NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALL 1411



 Score =  103 bits (256), Expect = 8e-22
 Identities = 149/726 (20%), Positives = 303/726 (41%), Gaps = 86/726 (11%)

Query: 55   DLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQ 114
            +L  +L  +  +I+KL A L+          ++ + L    +  + S +   +   E  +
Sbjct: 561  ELRIKLAIKEAEIQKLHANLT--------ANQLSQSLITCNDSQESSKLSSLE--TEPVK 610

Query: 115  ANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELE 174
                ++AE +      KDQ       Q EKE+  L   ++E++ + + +     ++    
Sbjct: 611  LGGHQVAESV------KDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNM 664

Query: 175  GFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQ 234
              +  +   I+  LL+K  +  K+E E+  +  +L   +++L       S ++ K  EL+
Sbjct: 665  AHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELE 724

Query: 235  RHYSTLEEQ---------RDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAE 285
            +      E+          +H        ++K   LEQ  +E++  I++L   L+K   +
Sbjct: 725  QELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQ-HKEMEKQIERLEAQLEKKDQQ 783

Query: 286  TQEKEDVITHLQEKVASLEKRLEQ------NLSGEEHVQELLKEKTLAEQNLEDTRQQLL 339
             +E+E  ++ LQ+ +   +  LE          GE   + + K++ L     + + + + 
Sbjct: 784  FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIK 843

Query: 340  AARSSQAKAI--NTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHV 397
              +   A  I    L   + +LE   +  E+QL++    V   +   +EL   N      
Sbjct: 844  VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQ---KELKIKNHSLQET 900

Query: 398  QQQALALEQQFLERTQALEAQIV---ALERTRAADQTTAEQGMRQLEQENAALKECRNEY 454
             +Q + L+    ++ Q L+ + +    LE T    QT  E+ + +LEQE    +E   E 
Sbjct: 901  SEQNVILQHTLQQQQQMLQQETIRNGELEDT----QTKLEKQVSKLEQELQKQRESSAEK 956

Query: 455  ERSLQN------HQFELKKLK--EEWSQREIVSVAMAQALEEVRKQREE---FQQQAANL 503
             R ++       H+ +LK+ K  E       V + M Q  EE+ K  +E    ++   N 
Sbjct: 957  LRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENK 1016

Query: 504  TAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRT-LKAEEAAV 562
               + + +  L +    L +K   + +LE+  +S   ++ +   + E L T L+     +
Sbjct: 1017 AMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGEL 1076

Query: 563  VAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKE 622
             +    L  LR  LQ   LS+ E + T + +   + +          E+  MD   L++ 
Sbjct: 1077 KSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMD-QALKER 1135

Query: 623  KQDLEQ---QLLEKNKTIK----QMQQRMLELRKTLQK-ELKIRPDNELFEVREKPGPEM 674
              +L+Q   Q+   + TI+    +M+Q++++L  TL+K EL+++  N+  E         
Sbjct: 1136 NWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIE--------- 1186

Query: 675  ANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENML 734
                   + N  L +A+E      + ++L+     E E   L K +       +E E+++
Sbjct: 1187 -------SLNDKLQNAKE-QLREKEFIMLQ----NEQEISQLKKEIERTQQRMKEMESVM 1234

Query: 735  KETLEY 740
            KE  +Y
Sbjct: 1235 KEQEQY 1240



 Score =  100 bits (249), Expect = 5e-21
 Identities = 139/688 (20%), Positives = 297/688 (43%), Gaps = 105/688 (15%)

Query: 51   SSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIA---------LEKHQDS 101
            +   +L  ++  +NE++   +  +     ++R+L+KI  +L +          L K+Q S
Sbjct: 480  NENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMS 539

Query: 102  SMRKFQEQ-NETFQANRAKMAEGLALALARK------------------------DQEWS 136
            S    +++     +AN+  ++E L + LA K                        D + S
Sbjct: 540  SFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES 598

Query: 137  EKMDQLEKEK-----NILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKK 191
             K+  LE E      + +   +++    +MN    ++    + G ++     ++  L++ 
Sbjct: 599  SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEE-----LRTKLIQI 653

Query: 192  EESLGKMEQELEARTRELSRTQEELM----NSNQMSSDLSQKLEELQRHYSTLEEQRDHV 247
            E     ++  +  RT +    QEEL+    NS+++ S++++K  +L     TLE+Q +  
Sbjct: 654  EAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQL----LTLEKQLEEK 709

Query: 248  IASKTGAESKITALEQ----KEQELQALIQQLSIDLQKV--TAETQEKEDVITH--LQEK 299
            I + +   +K   LEQ    K +++++L   ++ + +K+    E  +K  +  H  ++++
Sbjct: 710  IVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQ 769

Query: 300  VASLEKRLE---QNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAK--------A 348
            +  LE +LE   Q    +E    +L++  + +Q+  ++  +LL     + K        A
Sbjct: 770  IERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEA 829

Query: 349  INTLET-------RVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQA 401
            +  L+        +VR+L+  L+  +E+L      +   + + ++      E  +  Q+ 
Sbjct: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889

Query: 402  LALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQE---NAALKECRNEYERSL 458
            L ++   L+ T   E  ++         Q T +Q  + L+QE   N  L++ + + E+ +
Sbjct: 890  LKIKNHSLQETS--EQNVIL--------QHTLQQQQQMLQQETIRNGELEDTQTKLEKQV 939

Query: 459  QNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKT 518
               + EL+K +E  +++      M +  E    + +  +Q+   LT    + +  + +  
Sbjct: 940  SKLEQELQKQRESSAEK---LRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYK 996

Query: 519  EVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQA 578
            E L + E+EI+ L+R   +  + + QL   L+  +T   ++   V E E L         
Sbjct: 997  EELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056

Query: 579  EALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEK-----QDLEQQLLEK 633
            EAL   E  V    +Q+   +L +  R        +   QL  E+     +DL  +L E 
Sbjct: 1057 EALQKRE--VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELREC 1114

Query: 634  NKTIKQMQQRMLELRKTLQK---ELKIR 658
               I+  +Q +LE+ + L++   ELK R
Sbjct: 1115 KMEIEDKKQELLEMDQALKERNWELKQR 1142



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 130/646 (20%), Positives = 266/646 (41%), Gaps = 76/646 (11%)

Query: 65   EQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGL 124
            E++R +  + S+   Q+   ++   KLE  LE   +    KF   NE  +      A+  
Sbjct: 435  EKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNE 494

Query: 125  ALALARKDQEWS-------EK-MDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGF 176
             L L +++ E S       EK + QL  ++ +   +    K Q  +   + D        
Sbjct: 495  RLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEA 554

Query: 177  QQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRH 236
             +  +S+++  L  KE  + K+   L A     ++  + L+  N   S  S KL  L+  
Sbjct: 555  NKLVISELRIKLAIKEAEIQKLHANLTA-----NQLSQSLITCN--DSQESSKLSSLETE 607

Query: 237  YSTLEEQRDHVIASKTGAESKITALEQKEQELQAL---IQQLSIDLQKVTAETQEKEDVI 293
               L     H +A     +++ T  +Q E+E Q L   I++L   L ++ AE  + +  +
Sbjct: 608  PVKL---GGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNM 664

Query: 294  THLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLE 353
             H   +   +++ L +  S    ++  + +K      LE   ++ + A SS A     LE
Sbjct: 665  AHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELE 724

Query: 354  TRVRELEQTLQASEEQLQQSKGIVA-----AQETQIQELAAANQESSHVQQQALALEQQF 408
              + E  + +++ E  +      +      A++  +++     ++   ++ Q    +QQF
Sbjct: 725  QELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQF 784

Query: 409  LERTQA---LEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNH-QFE 464
             E+ +    L+  I+  +    +      +   ++++EN      ++E  ++LQN    E
Sbjct: 785  KEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMK----KDEALKALQNQVSEE 840

Query: 465  LKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAAN-------LTAIIDEKEQNLREK 517
              K+++  S  EI    +   L ++   +E+F++Q          L   +  K  +L+E 
Sbjct: 841  TIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQET 900

Query: 518  TEV------LLQKEQEILQLERGHNSAL--------LQIHQLQAELEALRTLKAEEAAVV 563
            +E        LQ++Q++LQ E   N  L         Q+ +L+ EL+  R   AE+   +
Sbjct: 901  SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM 960

Query: 564  AE------------QEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEV 611
             E            ++ ++ L G  +   + +++       M+  +  L       +GE 
Sbjct: 961  EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGEN 1015

Query: 612  GAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRM----LELRKTLQK 653
             AM L+QL       + +L +K   +K++++       EL + LQK
Sbjct: 1016 KAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQK 1061



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 85/419 (20%), Positives = 181/419 (43%), Gaps = 35/419 (8%)

Query: 153 LQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEART-RELSR 211
           L EM++ S + + + +E + L       ++ ++H L   E SL  + +EL + +  E S 
Sbjct: 116 LGEMESSSSDYYNKDNEEESLLA----NVASLRHELKITEWSLQSLGEELSSVSPSENSD 171

Query: 212 TQEELMNSNQMSSDLSQKLEELQRHYSTLE--------------EQRDHVIASKTGAESK 257
                  S ++  D+      L  +YS  E              + RD + +S    + +
Sbjct: 172 YAPNPSRSEKLILDVQPSHPGLL-NYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQE 230

Query: 258 ITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHV 317
           I +L +K  +L+     L      +  + +     +T  + KV+ LE   +Q  S     
Sbjct: 231 IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS----- 285

Query: 318 QELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIV 377
             +L+E+ +   NLE       A  S+Q K +   E ++ + ++ +   E+ LQ+SK   
Sbjct: 286 VPILEEQII---NLE-------AEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEEC 335

Query: 378 AAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGM 437
              +  + E     + +   + +AL   ++  +  Q  + ++        A++   E+ +
Sbjct: 336 IKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNL 395

Query: 438 RQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQ 497
              E+EN  L+E    Y+  L+  + +L++LKEE +  +     MA    EV  Q  E +
Sbjct: 396 TNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESR 455

Query: 498 QQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLK 556
           Q    L + ++ K++ LR+K  ++ +  +  +++   +    L   ++++    LR+L+
Sbjct: 456 QSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLE 514



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 136/650 (20%), Positives = 256/650 (39%), Gaps = 136/650 (20%)

Query: 138 KMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLG- 196
           K+  LE  +    A +  ++ Q +NL       D++    + +L + + M+++KE+SL  
Sbjct: 272 KVSMLESAQQ-QAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQE 330

Query: 197 ------KMEQELEARTRELSRTQ----EELMNSNQMS-------SDLSQKLEELQRHYST 239
                 K++ +L  +T++  R +    E L N+ ++S         +++KLE++Q     
Sbjct: 331 SKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI 390

Query: 240 LE------EQRDHVIASKTG----------------------AESKITALEQKEQELQAL 271
           LE      E+ +  +  + G                       + K+  +  K  E+ A 
Sbjct: 391 LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ 450

Query: 272 IQQLSIDLQKVTAETQEKEDVI----------THLQEKVASLEKRLE--QNLSGEEHVQE 319
           + +    + K+ +E + K++++            L+ +VA+  +RL+  Q       V+ 
Sbjct: 451 LTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVEL 510

Query: 320 LLKEKTLAEQNLED---------TRQQLLAARSSQAKAINTLETR---VRELEQTLQASE 367
              EK +++  L+          ++ Q+ +  + + + I   E     + EL   L   E
Sbjct: 511 RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE 570

Query: 368 EQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEA--------QI 419
            ++Q+    + A +   Q L   N      +  +L  E   L   Q  E+          
Sbjct: 571 AEIQKLHANLTANQLS-QSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMN 629

Query: 420 VALERTRAADQTTAEQ---GMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQRE 476
              E+ R    T  E+    + Q+E EN+ LK          Q  Q EL +     S+ E
Sbjct: 630 KQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE 689

Query: 477 IVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEI-------- 528
                    L  + KQ EE     +++ A   E EQ L EK E +   E  I        
Sbjct: 690 SEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC 749

Query: 529 --------LQLERGHNSALLQIHQLQAELEAL-RTLKAEEAAVVAEQEDLLRLRGPLQA- 578
                   + LE+ H     QI +L+A+LE   +  K +E  +   Q+D++  +  L++ 
Sbjct: 750 LAFEKAKKIHLEQ-HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESL 808

Query: 579 -------------------EALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQL 619
                              EAL   ++ V+   ++  V QL +A      E+  + L QL
Sbjct: 809 DRLLTESKGEMKKENMKKDEALKALQNQVSEETIK--VRQLDSALEICKEEL-VLHLNQL 865

Query: 620 QKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREK 669
           +  K+  E+QL +K++ +             LQKELKI+ ++ L E  E+
Sbjct: 866 EGNKEKFEKQLKKKSEEV-----------YCLQKELKIK-NHSLQETSEQ 903


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  114 bits (285), Expect = 3e-25
 Identities = 162/727 (22%), Positives = 310/727 (42%), Gaps = 95/727 (13%)

Query: 1    MFAKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGA------DSGDDFASDGSSSRE 54
            + ++ K  +A    VAQ+     R  R   + +   +        +  +D   DG+  R 
Sbjct: 600  LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659

Query: 55   DLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKI------------KEKLEIA--LEKHQ- 99
            +L     R + Q+ +LE + S  A+++  +++              EK E+A  L K + 
Sbjct: 660  ELE----RSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEA 715

Query: 100  -----DSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQ 154
                 + SM K + +  + Q + +K++  L  +LA+   + +  + QLE+EK+ L  + +
Sbjct: 716  GRVELELSMTKLRAEEASLQDSLSKLS-ALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 774

Query: 155  EMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQE 214
            + + ++    + ++ ++EL   Q+     ++  L   E++   +EQ+L     E S+ QE
Sbjct: 775  QAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQE 834

Query: 215  ELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQ 274
            +L   ++  S   Q+LE+ +R     E QR      +   E +  A E     +Q +  +
Sbjct: 835  QLAQLSRQLSGREQELEQARR-----EAQRQVEALERAAREKEALAKEHAGLAVQLVAAE 889

Query: 275  -----LSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQ 329
                 LS +  ++  E +  E  +  +Q ++A LE R EQ    E   Q LL  K     
Sbjct: 890  REGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQL---EAEGQALLLAKETLTG 946

Query: 330  NLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAA 389
             L   RQQ++A   +Q KA    E   ++L Q  + ++  L++ +   AA E  +Q L  
Sbjct: 947  ELAGLRQQIIA---TQEKASLDKELMAQKLVQAEREAQASLREQR---AAHEEDLQRLQR 1000

Query: 390  ANQ--------ESSHVQQQALALEQQFLERTQA----LEAQIVALERTRAADQTTAE--- 434
              +        E + +Q Q    +++ L R +A    L  +I AL++ R      AE   
Sbjct: 1001 EKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060

Query: 435  -QGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQRE----IVSVAMAQALEEV 489
             Q +   E E  AL E       SL     E+++ K +   R+        A+   L ++
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL 1120

Query: 490  RKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLER-------GHNSALLQI 542
            R QREE     A     + E+ ++L ++ +  L++ +E+    R       G    LL+ 
Sbjct: 1121 RAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEA 1180

Query: 543  HQLQAELEALRTLKAEEAAVV--------AEQEDLLRLRGPLQAEALSVNESHVTSRAMQ 594
             +   E +  R ++ +EA  +         E+E L R    L++         ++ +   
Sbjct: 1181 QRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLAN 1240

Query: 595  DPVFQ---LPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQM--QQRMLELRK 649
            +   Q   L    RT  G+    +  +L+   Q++E+  LE  + ++++  Q +ML+   
Sbjct: 1241 EDKEQKLALLEEARTAVGK----EAGELRTGLQEVERSRLEARRELQELRRQMKMLDSEN 1296

Query: 650  T-LQKEL 655
            T L +EL
Sbjct: 1297 TRLGREL 1303



 Score =  107 bits (268), Expect = 3e-23
 Identities = 152/652 (23%), Positives = 269/652 (41%), Gaps = 123/652 (18%)

Query: 54   EDLSSQLLRRNEQIRKLEARLSDYAEQVR----NLQKIKEKLEIALEKHQDSS--MRKFQ 107
            +D+  +     + +  L  +LSD   + R     LQ++++K + A++ H+D+   +++ +
Sbjct: 536  QDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLR 595

Query: 108  EQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRR 167
              NE     ++ +A  L +A         ++ ++L +E+  L A  +E++ Q       R
Sbjct: 596  SANELLSREKSNLAHSLQVA--------QQQAEELRQEREKLQAAQEELRRQ-------R 640

Query: 168  DEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLS 227
            D ++E +    Q+ ++++                     REL R+  +L       S L+
Sbjct: 641  DRLEEEQEDAVQDGARVR---------------------RELERSHRQLEQLEGKRSVLA 679

Query: 228  QKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQ 287
            ++L E++   S    QRD + A K      +T  E    EL+       + + K+ AE  
Sbjct: 680  KELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE-------LSMTKLRAEEA 732

Query: 288  EKEDVITHLQEKVASLEKRLEQN-LSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQA 346
              +D ++    K+++L + L Q+ L     V +L +EK+  +       Q+   AR  Q 
Sbjct: 733  SLQDSLS----KLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQE 788

Query: 347  KAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQ 406
            +    LE    E E   Q  E  L+ ++    AQE   Q+L     E S +Q+Q   L +
Sbjct: 789  R----LEELRLEQEVARQGLEGSLRVAE---QAQEALEQQLPTLRHERSQLQEQLAQLSR 841

Query: 407  QFLERTQALE-------AQIVALERTR-------------AADQTTAEQGMRQLEQENAA 446
            Q   R Q LE        Q+ ALER               A     AE+  R L +E   
Sbjct: 842  QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901

Query: 447  LKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQ------- 499
            L+  +   E SL   Q +L +L+    Q E    A+  A E +  +    +QQ       
Sbjct: 902  LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEK 961

Query: 500  --------AANLTAIIDEKEQNLREKTEV------LLQKEQEI----LQLERGHNSALLQ 541
                    A  L     E + +LRE+          LQ+E+E     L+ ER    + LQ
Sbjct: 962  ASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQ 1021

Query: 542  IHQ--LQAELEALRTLKAEE-AAVVAEQEDLLRLRGPLQAEALSVNESHVT--SRAMQDP 596
              Q  L A LEA +   +EE AA+  E+++ L L    + +ALS+ ES  T  S  +   
Sbjct: 1022 REQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081

Query: 597  VFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELR 648
               L T               +++++K+D + +  +   T+  +   + +LR
Sbjct: 1082 RHSLATIS------------LEMERQKRDAQSRQEQDRSTVNALTSELRDLR 1121



 Score =  102 bits (255), Expect = 1e-21
 Identities = 110/479 (22%), Positives = 213/479 (44%), Gaps = 43/479 (8%)

Query: 140  DQLEKEKNILTAQLQEMK-------NQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKE 192
            D+L  + + L  QL EM+       +++  L +   E +E        LS ++  L  +E
Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQE 1585

Query: 193  ESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKT 252
            ES+ + E+E  A   +++  +  L  +        +K+ +++ + + LE  +  +     
Sbjct: 1586 ESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLD 1645

Query: 253  GAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLS 312
             +ES+   LE + + L+  +Q+  + L    A+ Q  +D +  LQ +VA  E +      
Sbjct: 1646 ASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL 1705

Query: 313  GEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQ 372
              E +   L +   +E  L D  + L  A +  + ++N+   +   L++ L A E   Q 
Sbjct: 1706 TVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQV 1765

Query: 373  SKGIVAAQETQIQELAAANQESSHVQQQALALEQQF----LERTQALEAQIVALE---RT 425
             +  + A     Q L+ A ++SS + +Q   L  +     L+R +A E Q+  L    R 
Sbjct: 1766 LQERLDAAR---QALSEARKQSSSLGEQVQTLRGEVADLELQRVEA-EGQLQQLREVLRQ 1821

Query: 426  RAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQA 485
            R   +  A   +++L+ E   L+E     +R+L   + E ++++    + E   VA+ + 
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRT 1881

Query: 486  LEEVRKQREEFQQQAANLTA-------IIDEKEQNLREKTEVLLQKEQEILQLERGHNSA 538
            L++V +++    +    L+A        +   E  L E    + Q E +++ LE+ H+ A
Sbjct: 1882 LDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPA 1941

Query: 539  LLQIH------QLQAELEAL--------RTLKAEEAA----VVAEQEDLLRLRGPLQAE 579
             L++       +LQ E+E L        RTL+A E A    V   +E +  L+G LQ E
Sbjct: 1942 QLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE 2000



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 116/530 (21%), Positives = 231/530 (43%), Gaps = 61/530 (11%)

Query: 137  EKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLG 196
            +++   E E+  L  QLQ +++++    Q  ++       + Q L     +L +++ +L 
Sbjct: 554  KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR----EVQRLRSANELLSREKSNLA 609

Query: 197  KMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIAS----KT 252
               Q  + +  EL + +E+L  +           EEL+R    LEE+++  +      + 
Sbjct: 610  HSLQVAQQQAEELRQEREKLQAAQ----------EELRRQRDRLEEEQEDAVQDGARVRR 659

Query: 253  GAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLS 312
              E     LEQ E +   L ++L +++++  +    + D+   LQ + A + + L +  +
Sbjct: 660  ELERSHRQLEQLEGKRSVLAKEL-VEVREALSRATLQRDM---LQAEKAEVAEALTKAEA 715

Query: 313  GEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQ 372
            G   ++  + +    E +L+D+  +L A   S A+    L   V +LE+   A + + +Q
Sbjct: 716  GRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQ 775

Query: 373  SKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTT 432
            ++          QE   A +E   +++  L LEQ+     Q LE  +             
Sbjct: 776  AE----------QEATVAREEQERLEE--LRLEQEVAR--QGLEGSL-----------RV 810

Query: 433  AEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQ 492
            AEQ    LEQ+   L+  R++ +  L     +L   ++E  Q    +    +ALE   ++
Sbjct: 811  AEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAARE 870

Query: 493  REEFQQQAANLTA--IIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELE 550
            +E   ++ A L    +  E+E     +    L+ E+E L+       +L ++ +  A+LE
Sbjct: 871  KEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALE------GSLFEVQRQLAQLE 924

Query: 551  ALR-TLKAEEAAVVAEQEDLLRLRGPLQAEALSVNE-SHVTSRAMQDPVFQLPTAGRTPN 608
            A R  L+AE  A++  +E L      L+ + ++  E + +    M   + Q     +   
Sbjct: 925  ARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASL 984

Query: 609  GEVGAM---DLTQLQKEKQDLEQQL-LEKNKTIKQMQQRMLELRKTLQKE 654
             E  A    DL +LQ+EK+   ++L  E+ +   Q+Q+   EL   L+ E
Sbjct: 985  REQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAE 1034



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 115/493 (23%), Positives = 221/493 (44%), Gaps = 46/493 (9%)

Query: 203  EARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALE 262
            EA    L    +EL ++ +   +L  +   L R  + +E +RD   +     +  +   E
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564

Query: 263  QKEQELQALIQ--QLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQEL 320
            +  + +   +   Q  + LQ+ +    E+E   T   ++VA+LE+ L+   S     QE 
Sbjct: 1565 EARRSVDGRLSGVQAELALQEESVRRSERERRAT--LDQVATLERSLQATESELRASQEK 1622

Query: 321  LKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQ 380
            + +    E  LE  +++L        + ++  E+R  +LE   ++ E +LQ+S+  ++ +
Sbjct: 1623 ISKMKANETKLEGDKRRL-------KEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR 1675

Query: 381  ETQIQELAAANQESSHVQQQALALEQQ--FLERT-QALEAQIVALERTRAADQTTAEQGM 437
            E Q Q   A       +Q+Q    E +   L+ T + L   +  +E +  A +       
Sbjct: 1676 EAQAQ---ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLT 1732

Query: 438  RQLEQENAALKECRNE---YERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQRE 494
              L Q +A+L   R++    +++L   + + + L+E          A  QAL E RKQ  
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD-------AARQALSEARKQSS 1785

Query: 495  EFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEIL-QLERGHNSALLQIHQLQAE----L 549
               +Q   L   + + E   R + E  LQ+ +E+L Q + G  +AL  + +LQ E     
Sbjct: 1786 SLGEQVQTLRGEVADLELQ-RVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ 1844

Query: 550  EALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNES-----HVTSRAMQDPVFQLPTAG 604
            E L +L+   A + AE+ ++ R    L+ + +++  +         R+ +D V      G
Sbjct: 1845 ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKG 1904

Query: 605  RTPNGEVGA-MDLTQLQKEKQDLEQQ--LLEKNKTIKQM----QQRMLELRKTLQKELKI 657
            R      GA ++L + Q++ Q LE Q  +LE++ +  Q+    QQ+ LEL++ +++    
Sbjct: 1905 RLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSA 1964

Query: 658  RPDNE-LFEVREK 669
            +   E   E RE+
Sbjct: 1965 QAQTERTLEARER 1977



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 135/712 (18%), Positives = 260/712 (36%), Gaps = 84/712 (11%)

Query: 5    LKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRN 64
            L  K +E+TA++++  G      ++S E               D  S +E   S +    
Sbjct: 1064 LSLKESEKTALSEKLMGTRHSLATISLEMERQK---------RDAQSRQEQDRSTVNALT 1114

Query: 65   EQIRKLEARLSD----YAEQVRNLQKIKEKLEIALEKHQDSSMRKFQE---QNETFQANR 117
             ++R L A+  +    +A++VR LQ+    L     K +DS +R+ +E   Q    +  R
Sbjct: 1115 SELRDLRAQREEAAAAHAQEVRRLQEQARDLG----KQRDSCLREAEELRTQLRLLEDAR 1170

Query: 118  AKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQ 177
              +   L L   RK +E  E  +   +E   L   L E   +   L +  +E+       
Sbjct: 1171 DGLRREL-LEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA 1229

Query: 178  QQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHY 237
            + E   +K     KE+ L  +E+   A  +E    +  L    +   +  ++L+EL+R  
Sbjct: 1230 ESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQM 1289

Query: 238  STLEEQRDHVIASKTGAESKITALEQKEQELQ----ALIQQLSIDLQKVTAETQEKEDVI 293
              L+ +   +       + ++   E+ E+E +     L Q+L      +    QE +   
Sbjct: 1290 KMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQ 1349

Query: 294  THLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLE 353
              LQE+      R  + L   E  +   K++    + LE   +   A  +     ++  E
Sbjct: 1350 RKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAE 1409

Query: 354  TRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQ 413
             R + LE  L   E Q + ++  +    + ++      +  S   +           R  
Sbjct: 1410 GRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSP----ARDA 1465

Query: 414  ALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYER-SLQNHQFELKKLKEEW 472
              E     L      + +   Q        + A  +   E  R +L+    EL+  + E 
Sbjct: 1466 PAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRER 1525

Query: 473  SQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLRE--------KTEVLLQK 524
             +    + A+ + L E+  +R+    +A  L   + E E+  R         + E+ LQ 
Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQ- 1584

Query: 525  EQEILQLERGHNSALLQIHQLQAELEALRT-----------------------------L 555
            E+ + + ER   + L Q+  L+  L+A  +                             L
Sbjct: 1585 EESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVL 1644

Query: 556  KAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMD 615
             A E+  V  +     L G LQ   L +++    ++A+QD V  L         + G + 
Sbjct: 1645 DASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQ 1704

Query: 616  LT----------------QLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTL 651
            LT                 L+ + + L + L + + ++   + + L L+K L
Sbjct: 1705 LTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 144/631 (22%), Positives = 256/631 (40%), Gaps = 154/631 (24%)

Query: 101 SSMRKFQEQN------ETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQ 154
           S ++ F E++      E  + +RA    GL L+   +  E S     LEK+  +L AQL+
Sbjct: 311 SEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAE-SRAEAALEKQA-LLQAQLE 368

Query: 155 EMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELS---- 210
           E         Q RD++   +   QQ++          +  L K +  L AR  EL     
Sbjct: 369 E---------QLRDKVLREKDLAQQQM----------QSDLDKAD--LSARVTELGLAVK 407

Query: 211 RTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQA 270
           R +++ +  +Q++ DL++KLE L+     L+EQ                ALE ++ E   
Sbjct: 408 RLEKQNLEKDQVNKDLTEKLEALES--LRLQEQ---------------AALETEDGEG-- 448

Query: 271 LIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEE--------------- 315
            +QQ   DL +      E    ++   E+ A       + LSG+                
Sbjct: 449 -LQQTLRDLAQAVLSDSESGVQLSG-SERTADASNGSLRGLSGQRTPSPPRRSSPGRGRS 506

Query: 316 ----------------------HVQEL----LKEKTLAEQNLEDTRQQLLAARSSQAKAI 349
                                 H ++L    ++ +  A Q+L  T ++ L+   S+ +A+
Sbjct: 507 PRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRAL 566

Query: 350 NTLETRVRE-LEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQF 408
                R+R+  +  +QA E+  ++ + + +A E   +E +         QQQA  L Q+ 
Sbjct: 567 EEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQE- 625

Query: 409 LERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKE---CRNEYERSLQNHQFEL 465
                         E+ +AA +    Q  R  E++  A+++    R E ERS  + Q E 
Sbjct: 626 -------------REKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERS--HRQLEQ 670

Query: 466 KKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNL--REKTEVLLQ 523
            + K     +E+V V   +AL     QR+  Q + A +   + + E      E +   L+
Sbjct: 671 LEGKRSVLAKELVEV--REALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728

Query: 524 KEQEILQLERGHNSAL--------LQIHQLQAELE----AL--RTLKAEEAAVVAEQE-- 567
            E+  LQ      SAL        L +++L A+LE    AL  R  +AE+ A VA +E  
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQE 788

Query: 568 --DLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQD 625
             + LRL   +  + L      V  +A +    QLPT                L+ E+  
Sbjct: 789 RLEELRLEQEVARQGLE-GSLRVAEQAQEALEQQLPT----------------LRHERSQ 831

Query: 626 LEQQLLEKNKTIKQMQQRMLELRKTLQKELK 656
           L++QL + ++ +   +Q + + R+  Q++++
Sbjct: 832 LQEQLAQLSRQLSGREQELEQARREAQRQVE 862



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 131/626 (20%), Positives = 255/626 (40%), Gaps = 65/626 (10%)

Query: 56  LSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQA 115
           L ++ L ++ QI  L A + +     RNL + +    + L   + +S+   QE+N+  Q 
Sbjct: 33  LGARDLAQDAQITSLPALIREIV--TRNLSQPESP--VLLPATEMASLLSLQEENQLLQQ 88

Query: 116 NRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEG 175
             +++ + LA + A +D+        L  + N ++ +L+    Q++ L     E  E  G
Sbjct: 89  ELSRVEDLLAQSRAERDE--------LAIKYNAVSERLE----QALRLEPGELETQEPRG 136

Query: 176 FQQQELSKIKHMLLKKEESLGKMEQELEARTRE---LSRTQEELMNSNQMSSDLSQKLEE 232
             +Q +   + +  ++     K++   E + R+   + R Q +++   +  S+L Q+L E
Sbjct: 137 LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196

Query: 233 LQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDV 292
                  LE+QR          ES +  LE+ EQ+  A + Q++  L++   +       
Sbjct: 197 RS---GELEQQRLRDTEHSQDLESALIRLEE-EQQRSASLAQVNAMLREQLDQAGSANQA 252

Query: 293 ITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTL 352
           ++    KV +   R  + L   E      +E   A  + E +R  LL     Q      L
Sbjct: 253 LSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLL---WRQVVGFRRL 309

Query: 353 ETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERT 412
            + V+        +E  L Q  G +A     +QE   A    S   + A +  +  LE+ 
Sbjct: 310 VSEVK------MFTERDLLQLGGELARTSRAVQE---AGLGLSTGLRLAESRAEAALEKQ 360

Query: 413 QALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEW 472
             L+AQ+    R +   +    Q   Q + + A L     E           +K+L+++ 
Sbjct: 361 ALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTEL-------GLAVKRLEKQN 413

Query: 473 SQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLE 532
            +++ V+  + + LE +   R   Q+QAA  T   +  +Q LR+  + +L   +  +QL 
Sbjct: 414 LEKDQVNKDLTEKLEALESLR--LQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLS 471

Query: 533 RGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNES------ 586
               +A        A   +LR L  +       +    R R P +  + + ++S      
Sbjct: 472 GSERTA-------DASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALI 524

Query: 587 HVTSRAMQDPVFQLPTAGRTPNGEVGAM--DLTQLQKEKQDLEQQLLEKNKTIKQMQQRM 644
           H      Q  V  +          +G +   L+  + E++ LE+QL    + ++      
Sbjct: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL----QRLRDKTDGA 580

Query: 645 LELRKTLQKEL-KIRPDNELFEVREK 669
           ++  +  Q+E+ ++R  NEL   REK
Sbjct: 581 MQAHEDAQREVQRLRSANELLS-REK 605



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 69/316 (21%), Positives = 129/316 (40%), Gaps = 45/316 (14%)

Query: 40   DSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQ 99
            DS     +D       L   + R N  + K+E       ++VR L +   +   +L   +
Sbjct: 1687 DSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR 1746

Query: 100  DSSMRKFQEQNETFQANRAKMAEGL-----ALALARKDQE-WSEKMDQLEKEKNILTAQL 153
            D ++   Q+     + +R  + E L     AL+ ARK      E++  L  E   L  Q 
Sbjct: 1747 DKNLH-LQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQR 1805

Query: 154  QEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQ---ELEARTRELS 210
             E + Q   L +   +  E E      + K++      +E LG +++   +LEA  RE+ 
Sbjct: 1806 VEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVE 1865

Query: 211  RTQEELMNSNQMSSDLSQKLE--ELQRHYST--LEEQRDHVIASKTGAESKITALEQKEQ 266
            R+   L            K+E  +L+ H  T  L  ++  +  + TGAE ++   +++ Q
Sbjct: 1866 RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1925

Query: 267  ELQALI---------QQLSIDLQKVTAETQEKEDVITH---------------------- 295
            +L+A +          QL +D Q+   E Q++ + +                        
Sbjct: 1926 QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRG 1985

Query: 296  LQEKVASLEKRLEQNL 311
            L+E+V++L+ +L+Q L
Sbjct: 1986 LEEQVSTLKGQLQQEL 2001


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.123    0.313 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,541,969
Number of Sequences: 37866
Number of extensions: 1100005
Number of successful extensions: 26294
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 611
Number of HSP's successfully gapped in prelim test: 1290
Number of HSP's that attempted gapping in prelim test: 6940
Number of HSP's gapped (non-prelim): 7423
length of query: 767
length of database: 18,247,518
effective HSP length: 110
effective length of query: 657
effective length of database: 14,082,258
effective search space: 9252043506
effective search space used: 9252043506
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.