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Search of human proteins with 4503385
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
(443 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 901 0.0
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 824 0.0
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 384 e-106
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 268 7e-72
gi|32483397 dopamine receptor D4 [Homo sapiens] 234 9e-62
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 229 4e-60
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 209 3e-54
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 209 4e-54
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 207 2e-53
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 165 9e-41
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 159 4e-39
gi|194018562 histamine receptor H3 [Homo sapiens] 149 4e-36
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 5e-36
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 5e-36
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 5e-36
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 5e-36
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 5e-36
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 5e-36
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 5e-36
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 5e-36
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 149 5e-36
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 149 5e-36
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 149 5e-36
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 149 5e-36
gi|149158709 histamine receptor H1 [Homo sapiens] 149 5e-36
gi|149158706 histamine receptor H1 [Homo sapiens] 149 5e-36
gi|149158704 histamine receptor H1 [Homo sapiens] 149 5e-36
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 146 3e-35
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 144 1e-34
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 143 4e-34
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 901 bits (2329), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS 60
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
Sbjct: 1 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS 60
Query: 61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA 120
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
Sbjct: 61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA 120
Query: 121 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN 180
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
Sbjct: 121 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN 180
Query: 181 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL 240
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
Sbjct: 181 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL 240
Query: 241 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP 300
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
Sbjct: 241 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP 300
Query: 301 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR 360
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
Sbjct: 301 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR 360
Query: 361 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA 420
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
Sbjct: 361 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA 420
Query: 421 VNPIIYTTFNIEFRKAFLKILHC 443
VNPIIYTTFNIEFRKAFLKILHC
Sbjct: 421 VNPIIYTTFNIEFRKAFLKILHC 443
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 824 bits (2129), Expect = 0.0
Identities = 414/443 (93%), Positives = 414/443 (93%), Gaps = 29/443 (6%)
Query: 1 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS 60
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
Sbjct: 1 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS 60
Query: 61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA 120
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
Sbjct: 61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA 120
Query: 121 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN 180
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
Sbjct: 121 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN 180
Query: 181 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL 240
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
Sbjct: 181 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL 240
Query: 241 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP 300
K EAARRAQELEMEMLSSTSPPERTRYSPIPP
Sbjct: 241 K-----------------------------EAARRAQELEMEMLSSTSPPERTRYSPIPP 271
Query: 301 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR 360
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
Sbjct: 272 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR 331
Query: 361 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA 420
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
Sbjct: 332 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA 391
Query: 421 VNPIIYTTFNIEFRKAFLKILHC 443
VNPIIYTTFNIEFRKAFLKILHC
Sbjct: 392 VNPIIYTTFNIEFRKAFLKILHC 414
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 384 bits (985), Expect = e-106
Identities = 228/434 (52%), Positives = 272/434 (62%), Gaps = 65/434 (14%)
Query: 23 NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82
N + RPH YYA LI IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL
Sbjct: 19 NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77
Query: 83 VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141
VATLVMPWVVYLEV G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+
Sbjct: 78 VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137
Query: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198
Y T SS RRV +MI+ VWVL+F +SCPLLFG N D C I+NP FV+YSS+VSF
Sbjct: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197
Query: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKL----- 252
Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+ P + P ++L
Sbjct: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYS 257
Query: 253 -CTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPS 311
C F R EL+ E E+TR S P +L+L
Sbjct: 258 ICQDTALGGPGF---------QERGGELKRE--------EKTRNSLSPTIAPKLSL---- 296
Query: 312 HHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLS-QQKEKK 370
E++ + NG+ TSLK + +EKK
Sbjct: 297 ------------------------------EVRKLSNGRLSTSLKLGPLQPRGVPLREKK 326
Query: 371 ATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTF 429
ATQM+AIVLG FI+CWLPFF+TH+LN HC C++ P LYSA TWLGYVNSA+NP+IYTTF
Sbjct: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTF 386
Query: 430 NIEFRKAFLKILHC 443
NIEFRKAFLKIL C
Sbjct: 387 NIEFRKAFLKILSC 400
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 268 bits (685), Expect = 7e-72
Identities = 144/213 (67%), Positives = 167/213 (78%), Gaps = 6/213 (2%)
Query: 23 NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82
N + RPH YYA LI IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL
Sbjct: 19 NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77
Query: 83 VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141
VATLVMPWVVYLEV G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+
Sbjct: 78 VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137
Query: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198
Y T SS RRV +MI+ VWVL+F +SCPLLFG N D C I+NP FV+YSS+VSF
Sbjct: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197
Query: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSR 230
Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+
Sbjct: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQ 230
Score = 139 bits (350), Expect = 5e-33
Identities = 79/163 (48%), Positives = 97/163 (59%), Gaps = 32/163 (19%)
Query: 291 ERTRYSPIPPSHHQLTL-PDPSHHGLH--------STPDSPAKPEKNGHAKDHPKIAKIF 341
+ ++ + + P Q TL PDP+H L + P E+ G K K
Sbjct: 227 QNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEK----- 281
Query: 342 EIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD- 400
TR SL + +EKKATQM+AIVLG FI+CWLPFF+TH+LN HC
Sbjct: 282 ---------TRNSLMPL--------REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQT 324
Query: 401 CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
C++ P LYSA TWLGYVNSA+NP+IYTTFNIEFRKAFLKIL C
Sbjct: 325 CHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 234 bits (598), Expect = 9e-62
Identities = 159/407 (39%), Positives = 214/407 (52%), Gaps = 42/407 (10%)
Query: 43 LLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG-EWK 101
LLI ++ GN LVC++V+ E+ALQT TN IVSLA ADLL+A LV+P VY EV G W
Sbjct: 43 LLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL 102
Query: 102 FSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWV 161
S CD + +DVM+CTASI NLCAIS+DR+ AVA+P+ YN R RR ++I W+
Sbjct: 103 LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYN-RQGGSRRQLLLIGATWL 161
Query: 162 LSFTISCPLLFGLNNA---DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR 218
LS ++ P+L GLN+ D C + + +VVYSS+ SF++P + LL+Y + L+R
Sbjct: 162 LSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQR 221
Query: 219 RRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQE 278
+R + H RAP + + P + + P + A A
Sbjct: 222 -------WEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGP------DCAPPAPG 268
Query: 279 LEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEK---NGHAKDHP 335
L P +P PS Q DP G P +P P + A
Sbjct: 269 L-------PRGPCGPDCAPAAPSLPQ----DPC--GPDCAPPAPGLPPDPCGSNCAPPDA 315
Query: 336 KIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHIL 395
A QT P + R K R E+KA ++L +V+G F++CW PFF+ HI
Sbjct: 316 VRAAALPPQTPPQTRRRRRAKITGR-------ERKAMRVLPVVVGAFLLCWTPFFVVHIT 368
Query: 396 NIHCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
C C++PP L SA TWLGYVNSA+NP+IYT FN EFR F K L
Sbjct: 369 QALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 229 bits (584), Expect = 4e-60
Identities = 145/426 (34%), Positives = 221/426 (51%), Gaps = 47/426 (11%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
L LL+ + VFGNVLV +AV +AL+ N +VSLA AD+LVATLV+P+ + EV+G
Sbjct: 54 LAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY 113
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W F + C+I++ LDV+ CT+SI++LCAIS+DRY ++ + YN + + RR+ +I V
Sbjct: 114 WYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLK-RTPRRIKAIIITV 172
Query: 160 WVLSFTISCPLLFGLNNAD--------QNECIIANPAFVVYSSIV-SFYVPFIVTLLVYI 210
WV+S IS P L + + C I + + V SS + SF+ P ++ +LVY+
Sbjct: 173 WVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYV 232
Query: 211 KIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRV 270
+IY + +RR + ++R A + AP G P NG P R
Sbjct: 233 RIYQIAKRRTRVPPSRRGPDA----VAAPPGGTERRP------------NGLGP-ERSAG 275
Query: 271 EAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGH 330
A+ L ++ + P P L L + S P P +PE+
Sbjct: 276 PGGAEAEPLPTQLNGAPGEPAPAG----PRDTDALDLEESSSSDHAERPPGPRRPERGPR 331
Query: 331 AKDHPKIAKIFEIQTMPN---------------GKTRTSLKTMSRRKLSQQKEKKATQML 375
K + +++ ++P G+ R SR + Q +EK+ T +L
Sbjct: 332 GKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVL 391
Query: 376 AIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRK 435
A+V+GVF++CW PFF T+ L C++P L+ F W GY NS++NP+IYT FN +FR+
Sbjct: 392 AVVIGVFVVCWFPFFFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR 450
Query: 436 AFLKIL 441
AF KIL
Sbjct: 451 AFKKIL 456
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 209 bits (533), Expect = 3e-54
Identities = 137/436 (31%), Positives = 221/436 (50%), Gaps = 82/436 (18%)
Query: 37 YATLLTLLIAVIVF----GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVV 92
Y + +LL+ ++F GN V A++ E++LQ NYLI SLAV DL+V+ LV+P
Sbjct: 35 YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAA 94
Query: 93 YLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRV 152
+V+ +W ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+ P+ Y + + RR
Sbjct: 95 LYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNK-RTPRRA 153
Query: 153 TVMISIVWVLSFTISCPLLFGL----NNADQNECIIA-NPAFVVYSSIVSFYVPFIVTLL 207
+IS+ W++ F IS P + G + +D + C I+ + + +YS+ +FY+P ++ L+
Sbjct: 154 AALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLV 213
Query: 208 VYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCT-----------V 255
+Y +I+ R R RK V + A H +P P+ K V
Sbjct: 214 LYGRIFRAARFRIRKTVKKVEKTGADTRHGASPA------PQPKKSVNGESGSRNWRLGV 267
Query: 256 IMKSNGSFPVNR--RRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHH 313
K+ G+ N R+ + + +E+ + ++ LP PS
Sbjct: 268 ESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKE----------------HLPLPSEA 311
Query: 314 GLHSTPDSPA----KPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEK 369
G TP +PA K E+N AK RK++ +E+
Sbjct: 312 G--PTPCAPASFERKNERNAEAK----------------------------RKMALARER 341
Query: 370 KATQMLAIVLGVFIICWLPFFITHILNIHCD--CNIPPVLYSAFTWLGYVNSAVNPIIYT 427
K + L I++G FI+CWLPFFI ++ C+ C++P +L + WLGY NS +NP+IY
Sbjct: 342 KTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYA 401
Query: 428 TFNIEFRKAFLKILHC 443
FN +F+ AF KI+ C
Sbjct: 402 YFNKDFQNAFKKIIKC 417
>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
Length = 450
Score = 209 bits (532), Expect = 4e-54
Identities = 141/447 (31%), Positives = 229/447 (51%), Gaps = 64/447 (14%)
Query: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
A +T LI +FGN LV +AV ++L+ N +VSLA AD+LVATL++P+ + E++
Sbjct: 16 AAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELL 75
Query: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
G W F R C++++ LDV+ CT+SI++LCAIS+DRY AV+ + YN++ + RR+ +I
Sbjct: 76 GYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSK-RTPRRIKCIIL 134
Query: 158 IVWVLSFTISCPLLF-----GLNNADQNECIIANPA-FVVYSSIVSFYVPFIVTLLVYIK 211
VW+++ IS P L G + +C + A +++ SSI SF+ P ++ +LVY++
Sbjct: 135 TVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLR 194
Query: 212 IYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVE 271
IY++ KRS+R P +G P +G + +
Sbjct: 195 IYLI---------AKRSNRRGPRAKGGPGQGESKQPR---------PDHGGALASAKLPA 236
Query: 272 AARRAQELEMEMLSSTS-------PPERTRYSPIPPSHHQLTLPDPSH---HGL-HSTPD 320
A A E+ S ++ PE T +PPS LP+ G+ ++P+
Sbjct: 237 LASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPS--WAALPNSGQGQKEGVCGASPE 294
Query: 321 SPAKPEKNGHAKDH----------PKIAKIFEIQTMPNGKTRTSLKTMS----------- 359
A+ E+ ++ P A +Q + +L+
Sbjct: 295 DEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGG 354
Query: 360 ---RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC--DCNIPPVLYSAFTWL 414
RR+ +EK+ T +LA+V+GVF++CW PFF ++ L C C +P L+ F W+
Sbjct: 355 QWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWI 414
Query: 415 GYVNSAVNPIIYTTFNIEFRKAFLKIL 441
GY NS++NP+IYT FN +FR+AF +IL
Sbjct: 415 GYCNSSLNPVIYTIFNQDFRRAFRRIL 441
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 207 bits (526), Expect = 2e-53
Identities = 139/422 (32%), Positives = 215/422 (50%), Gaps = 42/422 (9%)
Query: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
A ++ LI V GNVLV +AV +AL+ N +VSLA AD+LVATLVMP+ + E++
Sbjct: 55 AAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELM 114
Query: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
W F ++ C +++ LDV+ CT+SI++LCAIS+DRY +V + YN + + RRV I
Sbjct: 115 AYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLK-RTPRRVKATIV 173
Query: 158 IVWVLSFTISCPLLFGL----NNADQNECIIANPAFVVYSSIV-SFYVPFIVTLLVYIKI 212
VW++S IS P L L + A +C + + + + SS + SF+ P ++ LVY +I
Sbjct: 174 AVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARI 233
Query: 213 YIVLRRRRKRVNTKR-----------SSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNG 261
Y V + R + ++ KR + A A G+C P V +
Sbjct: 234 YRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPP----ADVEPDESS 289
Query: 262 SFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDS 321
+ RRR A RR + Q P + G + S
Sbjct: 290 AAAERRRRRGALRRGGRRRAGAEGGAGGAD-----------GQGAGPGAAESGALTASRS 338
Query: 322 PAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGV 381
P + A + + F + R + ++ RRK++Q +EK+ T +LA+V+GV
Sbjct: 339 PGPGGRLSRASS--RSVEFF------LSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGV 390
Query: 382 FIICWLPFFITHILNIHC--DCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLK 439
F++CW PFF ++ L C C +P L+ F W+GY NS++NP+IYT FN +FR++F
Sbjct: 391 FVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKH 450
Query: 440 IL 441
IL
Sbjct: 451 IL 452
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 165 bits (417), Expect = 9e-41
Identities = 121/416 (29%), Positives = 184/416 (44%), Gaps = 98/416 (23%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
L+ L++ +IV GNVLV +A+++ LQT TN I+SLA ADL++ LV+P+ + V G
Sbjct: 64 LMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W++ C+++ ++DV+ TASI LC I++DRY A+ P Y + + + R ++ V
Sbjct: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLT-RARARGLVCTV 182
Query: 160 WVLSFTIS-CPLLFGLNNADQNEC-----------IIANPAFVVYSSIVSFYVPFIVTLL 207
W +S +S P+L A+ +E + N A+ + SS+VSFYVP
Sbjct: 183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC---- 238
Query: 208 VYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNR 267
I ++ LR V R
Sbjct: 239 --IMAFVYLR-----------------------------------------------VFR 249
Query: 268 RRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEK 327
+ ++ E L + P SP+P P P + P
Sbjct: 250 EAQKQVKKIDSCERRFLGGPARPPSPSPSPVPA-------PAPPPGPPRPAAAAATAPLA 302
Query: 328 NGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWL 387
NG A GK R S +L +E+KA + L I++GVF +CWL
Sbjct: 303 NGRA-----------------GKRRPS-------RLVALREQKALKTLGIIMGVFTLCWL 338
Query: 388 PFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
PFF+ +++ +P L+ F WLGY NSA NPIIY + +FRKAF +L C
Sbjct: 339 PFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCC 393
>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
Length = 479
Score = 159 bits (403), Expect = 4e-39
Identities = 126/482 (26%), Positives = 200/482 (41%), Gaps = 76/482 (15%)
Query: 21 PFNGSDGKAD-----RPHYNYYATLLTLLIAVI--------VFGNVLVCMAVSREKALQT 67
P NGS G +N Y T+ + IA + V GN+LV +++ + LQT
Sbjct: 6 PVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQT 65
Query: 68 TTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCA 127
NY + SLA ADL++ M + G W + CD+++ LD ++ AS++NL
Sbjct: 66 VNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLI 125
Query: 128 ISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLF------GLNNADQNE 181
IS DRY V P+ Y R ++K +MI+ WVLSF + P + G N+
Sbjct: 126 ISFDRYFCVTKPLTYPARRTTK-MAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQ 184
Query: 182 CII---ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR---RKRVNTKRSSRAFRAH 235
C I +NPA ++I +FY+P ++ ++YI I + R R + K A
Sbjct: 185 CFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAF 244
Query: 236 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPER--- 292
L++PL MK + P R +LE + PP R
Sbjct: 245 LKSPL----------------MKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVA 288
Query: 293 ---TRYSPIPPSHHQLTLPDPSHH---GLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTM 346
T S Q T P+ +TP PA P + + +KI +
Sbjct: 289 DKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQ 348
Query: 347 PNGKTRTSLK-------------------------TMSRRKLSQQKEKKATQMLAIVLGV 381
+ T+++ + +++ +E+K T+ + +L
Sbjct: 349 TGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLA 408
Query: 382 FIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
FI+ W P+ + ++N C IP ++S WL YVNS +NP Y N F+K F +L
Sbjct: 409 FILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 468
Query: 442 HC 443
C
Sbjct: 469 LC 470
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 149 bits (377), Expect = 4e-36
Identities = 110/420 (26%), Positives = 193/420 (45%), Gaps = 46/420 (10%)
Query: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
A L+ LLI V GN LV +A + +L+T N+ +++LA++D LV +P V +
Sbjct: 38 AALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLT 97
Query: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
G W F R C +++ +D ++CT+S N+ IS DR+ +V + Y + RR +
Sbjct: 98 GRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKML 157
Query: 158 IVWVLSFTISCP------LLFGLNNADQNEC---IIANPAFVVYSSIVSFYVPFIVTLLV 208
+VWVL+F + P L G ++ + C N F++ +S + F+ PF+
Sbjct: 158 LVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFF 217
Query: 209 YIKIYI-VLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNG-SFPVN 266
+ IY+ + RR R R++ R + A P + + P K +G + P++
Sbjct: 218 NLSIYLNIQRRTRLRLDGAREA----AGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLH 273
Query: 267 RRRV-EAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKP 325
R V EAA A+ E TL G ++P S +
Sbjct: 274 RYGVGEAAVGAEAGE------------------------ATLGGGGGGGSVASPTSSSGS 309
Query: 326 EKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR---RKLSQQKEKKATQMLAIVLGVF 382
G + P+ K + + +K +S+ ++ +++K + LA+++ +F
Sbjct: 310 SSRG--TERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIF 367
Query: 383 IICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
+CW P+ + I+ C + +P Y WL + NSAVNP++Y + FR+AF K+L
Sbjct: 368 GLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (376), Expect = 5e-36
Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252
+P I+ ++Y I + R K+ + S + + P N +D
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
Query: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302
I PV V+ + + +S+ + E T + + S
Sbjct: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
Query: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351
+ T S ++T + +NG K + KI ++ P
Sbjct: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
Query: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411
+++K +EKK T+ + +L FII W P+ + ++N C IP +++
Sbjct: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
Query: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
WL Y+NS +NP Y N F+K F +L C
Sbjct: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (376), Expect = 5e-36
Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252
+P I+ ++Y I + R K+ + S + + P N +D
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
Query: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302
I PV V+ + + +S+ + E T + + S
Sbjct: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
Query: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351
+ T S ++T + +NG K + KI ++ P
Sbjct: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
Query: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411
+++K +EKK T+ + +L FII W P+ + ++N C IP +++
Sbjct: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
Query: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
WL Y+NS +NP Y N F+K F +L C
Sbjct: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (376), Expect = 5e-36
Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252
+P I+ ++Y I + R K+ + S + + P N +D
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
Query: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302
I PV V+ + + +S+ + E T + + S
Sbjct: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
Query: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351
+ T S ++T + +NG K + KI ++ P
Sbjct: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
Query: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411
+++K +EKK T+ + +L FII W P+ + ++N C IP +++
Sbjct: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
Query: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
WL Y+NS +NP Y N F+K F +L C
Sbjct: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (376), Expect = 5e-36
Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252
+P I+ ++Y I + R K+ + S + + P N +D
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
Query: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302
I PV V+ + + +S+ + E T + + S
Sbjct: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
Query: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351
+ T S ++T + +NG K + KI ++ P
Sbjct: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
Query: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411
+++K +EKK T+ + +L FII W P+ + ++N C IP +++
Sbjct: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
Query: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
WL Y+NS +NP Y N F+K F +L C
Sbjct: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (376), Expect = 5e-36
Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252
+P I+ ++Y I + R K+ + S + + P N +D
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
Query: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302
I PV V+ + + +S+ + E T + + S
Sbjct: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
Query: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351
+ T S ++T + +NG K + KI ++ P
Sbjct: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
Query: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411
+++K +EKK T+ + +L FII W P+ + ++N C IP +++
Sbjct: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
Query: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
WL Y+NS +NP Y N F+K F +L C
Sbjct: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (376), Expect = 5e-36
Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252
+P I+ ++Y I + R K+ + S + + P N +D
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
Query: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302
I PV V+ + + +S+ + E T + + S
Sbjct: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
Query: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351
+ T S ++T + +NG K + KI ++ P
Sbjct: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
Query: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411
+++K +EKK T+ + +L FII W P+ + ++N C IP +++
Sbjct: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
Query: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
WL Y+NS +NP Y N F+K F +L C
Sbjct: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (376), Expect = 5e-36
Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252
+P I+ ++Y I + R K+ + S + + P N +D
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
Query: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302
I PV V+ + + +S+ + E T + + S
Sbjct: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
Query: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351
+ T S ++T + +NG K + KI ++ P
Sbjct: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
Query: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411
+++K +EKK T+ + +L FII W P+ + ++N C IP +++
Sbjct: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
Query: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
WL Y+NS +NP Y N F+K F +L C
Sbjct: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (376), Expect = 5e-36
Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252
+P I+ ++Y I + R K+ + S + + P N +D
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
Query: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302
I PV V+ + + +S+ + E T + + S
Sbjct: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
Query: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351
+ T S ++T + +NG K + KI ++ P
Sbjct: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
Query: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411
+++K +EKK T+ + +L FII W P+ + ++N C IP +++
Sbjct: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
Query: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
WL Y+NS +NP Y N F+K F +L C
Sbjct: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 149 bits (376), Expect = 5e-36
Identities = 87/232 (37%), Positives = 132/232 (56%), Gaps = 16/232 (6%)
Query: 2 DPLNLSWYDDDLER------QNWSRPFNGSDGKADRPHYN-----YYATLLTLLIAVIVF 50
DP+ SW L W P + + G ++ +Y ++LTL+ + +
Sbjct: 38 DPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIA 97
Query: 51 GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG-EWKFSRIHCDI 109
GN LV ++V K L+ +NYLIVSLA+ADL VA VMP+V +++G +W F C++
Sbjct: 98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNV 157
Query: 110 FVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCP 169
F+ +DVM CTASI+ LC ISIDRY + P+ Y R + K +++S VW+LS +I+ P
Sbjct: 158 FIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILS-VWLLSASITLP 216
Query: 170 LLFG--LNNADQNECIIANP-AFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR 218
LFG N D C+I+ + +YS+ V+FY+P V L +Y +IY R+
Sbjct: 217 PLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARK 268
Score = 72.8 bits (177), Expect = 6e-13
Identities = 34/83 (40%), Positives = 46/83 (55%), Gaps = 6/83 (7%)
Query: 366 QKEKKATQMLAIVLGVFIICWLPFFITH-----ILNIHCDCNIPPVLYSAFTWLGYVNSA 420
++E+KA L I++G F +CWLPFF+ I C C IP + F WLGY NS
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVERTFLWLGYANSL 378
Query: 421 VNPIIYTTFNIEFRKAFLKILHC 443
+NP IY FN + R + +L C
Sbjct: 379 INPFIYAFFNRDLRTTYRSLLQC 401
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 149 bits (376), Expect = 5e-36
Identities = 87/232 (37%), Positives = 132/232 (56%), Gaps = 16/232 (6%)
Query: 2 DPLNLSWYDDDLER------QNWSRPFNGSDGKADRPHYN-----YYATLLTLLIAVIVF 50
DP+ SW L W P + + G ++ +Y ++LTL+ + +
Sbjct: 38 DPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIA 97
Query: 51 GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG-EWKFSRIHCDI 109
GN LV ++V K L+ +NYLIVSLA+ADL VA VMP+V +++G +W F C++
Sbjct: 98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNV 157
Query: 110 FVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCP 169
F+ +DVM CTASI+ LC ISIDRY + P+ Y R + K +++S VW+LS +I+ P
Sbjct: 158 FIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILS-VWLLSASITLP 216
Query: 170 LLFG--LNNADQNECIIANP-AFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR 218
LFG N D C+I+ + +YS+ V+FY+P V L +Y +IY R+
Sbjct: 217 PLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARK 268
Score = 72.8 bits (177), Expect = 6e-13
Identities = 34/83 (40%), Positives = 46/83 (55%), Gaps = 6/83 (7%)
Query: 366 QKEKKATQMLAIVLGVFIICWLPFFITH-----ILNIHCDCNIPPVLYSAFTWLGYVNSA 420
++E+KA L I++G F +CWLPFF+ I C C IP + F WLGY NS
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVERTFLWLGYANSL 378
Query: 421 VNPIIYTTFNIEFRKAFLKILHC 443
+NP IY FN + R + +L C
Sbjct: 379 INPFIYAFFNRDLRTTYRSLLQC 401
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 149 bits (376), Expect = 5e-36
Identities = 87/232 (37%), Positives = 132/232 (56%), Gaps = 16/232 (6%)
Query: 2 DPLNLSWYDDDLER------QNWSRPFNGSDGKADRPHYN-----YYATLLTLLIAVIVF 50
DP+ SW L W P + + G ++ +Y ++LTL+ + +
Sbjct: 38 DPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIA 97
Query: 51 GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG-EWKFSRIHCDI 109
GN LV ++V K L+ +NYLIVSLA+ADL VA VMP+V +++G +W F C++
Sbjct: 98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNV 157
Query: 110 FVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCP 169
F+ +DVM CTASI+ LC ISIDRY + P+ Y R + K +++S VW+LS +I+ P
Sbjct: 158 FIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILS-VWLLSASITLP 216
Query: 170 LLFG--LNNADQNECIIANP-AFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR 218
LFG N D C+I+ + +YS+ V+FY+P V L +Y +IY R+
Sbjct: 217 PLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARK 268
Score = 72.8 bits (177), Expect = 6e-13
Identities = 34/83 (40%), Positives = 46/83 (55%), Gaps = 6/83 (7%)
Query: 366 QKEKKATQMLAIVLGVFIICWLPFFITH-----ILNIHCDCNIPPVLYSAFTWLGYVNSA 420
++E+KA L I++G F +CWLPFF+ I C C IP + F WLGY NS
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVERTFLWLGYANSL 378
Query: 421 VNPIIYTTFNIEFRKAFLKILHC 443
+NP IY FN + R + +L C
Sbjct: 379 INPFIYAFFNRDLRTTYRSLLQC 401
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 149 bits (376), Expect = 5e-36
Identities = 80/188 (42%), Positives = 118/188 (62%), Gaps = 5/188 (2%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
+L I + GN+LV ++V+ + L+T TNY IV+LA+ADLL++ V+P+ LEV+G
Sbjct: 51 VLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGY 110
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W RI CDI+ +DV+ CTASIL+LCAISIDRY V + Y T + ++ + ++S V
Sbjct: 111 WVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLS-V 169
Query: 160 WVLSFTISCPLLFGLNNA---DQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIV 215
WVLS IS L G D EC + P + ++SS+ SFY+P V L++Y ++YIV
Sbjct: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIV 229
Query: 216 LRRRRKRV 223
+R K +
Sbjct: 230 AKRTTKNL 237
Score = 78.6 bits (192), Expect = 1e-14
Identities = 37/78 (47%), Positives = 52/78 (66%), Gaps = 1/78 (1%)
Query: 367 KEKKATQMLAIVLGVFIICWLPFFITHIL-NIHCDCNIPPVLYSAFTWLGYVNSAVNPII 425
+EKKA + L IV+G+FI+CWLPFFI L ++ P ++ WLGY NS +NPII
Sbjct: 288 REKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPII 347
Query: 426 YTTFNIEFRKAFLKILHC 443
Y + EF++AF++IL C
Sbjct: 348 YPCSSKEFKRAFVRILGC 365
>gi|149158709 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 149 bits (376), Expect = 5e-36
Identities = 126/457 (27%), Positives = 207/457 (45%), Gaps = 59/457 (12%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
+L+ + V V N+LV AV E+ L T N IVSL+VADL+V +VMP + ++ +
Sbjct: 33 VLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSK 92
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W R C ++++D + TASI ++ + IDRY +V P+ Y +Y +K R + I
Sbjct: 93 WSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY-LKYRTKTRASATILGA 151
Query: 160 WVLSFTISCPLLFGLNNADQNECIIANPA----------FVVYSSIVSFYVPFIVTLLVY 209
W LSF P+L G N+ Q + F V ++I++FY+P ++ L Y
Sbjct: 152 WFLSFLWVIPIL-GWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210
Query: 210 IKIYIVLRRR-RKRVNTKRSSRAFRAHLRAP--LKGNCTHPEDMKLCTV----------- 255
KIY +R+ + R RS +F P KG+ P V
Sbjct: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270
Query: 256 -IMKSNGSFPVNRRRVEAARRAQELEMEML----------SSTSPPERTRYSPIPPSHHQ 304
++KS P + + + E++ L + + Y + SH Q
Sbjct: 271 SVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQ 330
Query: 305 LTLPDPSHHGLHSTPDSP-AKPEKNGHAKDHPKIAKIFEIQTMP-NGKTRTS-------- 354
L + GL++ S ++ + G ++ + +T P GK R+
Sbjct: 331 LKTDE---QGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYI 387
Query: 355 ------LKTMSRRKLS---QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPP 405
L++ SR+ +S +E+KA + L ++ FI+CW+P+FI ++ C
Sbjct: 388 KFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNE 447
Query: 406 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILH 442
L+ WLGY+NS +NP+IY N F+K F +ILH
Sbjct: 448 HLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILH 484
>gi|149158706 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 149 bits (376), Expect = 5e-36
Identities = 126/457 (27%), Positives = 207/457 (45%), Gaps = 59/457 (12%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
+L+ + V V N+LV AV E+ L T N IVSL+VADL+V +VMP + ++ +
Sbjct: 33 VLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSK 92
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W R C ++++D + TASI ++ + IDRY +V P+ Y +Y +K R + I
Sbjct: 93 WSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY-LKYRTKTRASATILGA 151
Query: 160 WVLSFTISCPLLFGLNNADQNECIIANPA----------FVVYSSIVSFYVPFIVTLLVY 209
W LSF P+L G N+ Q + F V ++I++FY+P ++ L Y
Sbjct: 152 WFLSFLWVIPIL-GWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210
Query: 210 IKIYIVLRRR-RKRVNTKRSSRAFRAHLRAP--LKGNCTHPEDMKLCTV----------- 255
KIY +R+ + R RS +F P KG+ P V
Sbjct: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270
Query: 256 -IMKSNGSFPVNRRRVEAARRAQELEMEML----------SSTSPPERTRYSPIPPSHHQ 304
++KS P + + + E++ L + + Y + SH Q
Sbjct: 271 SVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQ 330
Query: 305 LTLPDPSHHGLHSTPDSP-AKPEKNGHAKDHPKIAKIFEIQTMP-NGKTRTS-------- 354
L + GL++ S ++ + G ++ + +T P GK R+
Sbjct: 331 LKTDE---QGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYI 387
Query: 355 ------LKTMSRRKLS---QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPP 405
L++ SR+ +S +E+KA + L ++ FI+CW+P+FI ++ C
Sbjct: 388 KFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNE 447
Query: 406 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILH 442
L+ WLGY+NS +NP+IY N F+K F +ILH
Sbjct: 448 HLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILH 484
>gi|149158704 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 149 bits (376), Expect = 5e-36
Identities = 126/457 (27%), Positives = 207/457 (45%), Gaps = 59/457 (12%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
+L+ + V V N+LV AV E+ L T N IVSL+VADL+V +VMP + ++ +
Sbjct: 33 VLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSK 92
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W R C ++++D + TASI ++ + IDRY +V P+ Y +Y +K R + I
Sbjct: 93 WSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY-LKYRTKTRASATILGA 151
Query: 160 WVLSFTISCPLLFGLNNADQNECIIANPA----------FVVYSSIVSFYVPFIVTLLVY 209
W LSF P+L G N+ Q + F V ++I++FY+P ++ L Y
Sbjct: 152 WFLSFLWVIPIL-GWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210
Query: 210 IKIYIVLRRR-RKRVNTKRSSRAFRAHLRAP--LKGNCTHPEDMKLCTV----------- 255
KIY +R+ + R RS +F P KG+ P V
Sbjct: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270
Query: 256 -IMKSNGSFPVNRRRVEAARRAQELEMEML----------SSTSPPERTRYSPIPPSHHQ 304
++KS P + + + E++ L + + Y + SH Q
Sbjct: 271 SVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQ 330
Query: 305 LTLPDPSHHGLHSTPDSP-AKPEKNGHAKDHPKIAKIFEIQTMP-NGKTRTS-------- 354
L + GL++ S ++ + G ++ + +T P GK R+
Sbjct: 331 LKTDE---QGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYI 387
Query: 355 ------LKTMSRRKLS---QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPP 405
L++ SR+ +S +E+KA + L ++ FI+CW+P+FI ++ C
Sbjct: 388 KFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNE 447
Query: 406 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILH 442
L+ WLGY+NS +NP+IY N F+K F +ILH
Sbjct: 448 HLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILH 484
>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
Length = 460
Score = 146 bits (369), Expect = 3e-35
Identities = 115/422 (27%), Positives = 180/422 (42%), Gaps = 41/422 (9%)
Query: 43 LLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF 102
LL V GN+LV ++ L+T NY ++SLA ADL++ T M ++G W
Sbjct: 34 LLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWAL 93
Query: 103 SRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVL 162
+ CD+++ LD + AS++NL IS DRY +V P+ Y + + RR +MI + W++
Sbjct: 94 GTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAK-RTPRRAALMIGLAWLV 152
Query: 163 SFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFYVPFIVTLLVYIKIY 213
SF + P L G +C I + P +++ +FY+P V +Y +IY
Sbjct: 153 SFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIY 212
Query: 214 IVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAA 273
R + + + S P KG + + S + P R A
Sbjct: 213 RETENRARELAALQGS-------ETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRA 265
Query: 274 RR------------AQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDS 321
R E ME L+S+ E I P+ S+P++
Sbjct: 266 PRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNT 325
Query: 322 PAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGV 381
+P K G + P GK + + R+ S KEKKA + L+ +L
Sbjct: 326 VKRPTKKGRDRAGK--------GQKPRGKEQLA----KRKTFSLVKEKKAARTLSAILLA 373
Query: 382 FIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
FI+ W P+ I +++ C +P L+ WL YVNS +NP+ Y N FR F +L
Sbjct: 374 FILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLL 433
Query: 442 HC 443
C
Sbjct: 434 LC 435
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 144 bits (364), Expect = 1e-34
Identities = 80/213 (37%), Positives = 122/213 (57%), Gaps = 12/213 (5%)
Query: 41 LTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEW 100
L I + V GN+LV ++V+ + LQT TNY IV+LAVADLL++ V+P+ +EV+G W
Sbjct: 103 LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFW 162
Query: 101 KFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVW 160
F R CD++ +DV+ CTASIL+LC IS+DRY V + Y ++R+ +++++W
Sbjct: 163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKY-PAIMTERKAAAILALLW 221
Query: 161 VLSFTISCPLLFGLNN---ADQNECIIANPA-FVVYSSIVSFYVPFIVTLLVYIKIYIVL 216
V++ +S L G D+ C I A + V+SS+ SFY+P V +++Y ++Y+V
Sbjct: 222 VVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVA 281
Query: 217 RRRR-------KRVNTKRSSRAFRAHLRAPLKG 242
R KR K S R H R G
Sbjct: 282 RSTTRSLEAGVKRERGKASEVVLRIHCRGAATG 314
Score = 81.3 bits (199), Expect = 2e-15
Identities = 40/99 (40%), Positives = 60/99 (60%), Gaps = 1/99 (1%)
Query: 346 MPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLP-FFITHILNIHCDCNIP 404
M + K T ++S R L +EKKA + LAIV+GVF++CW P FF+ + ++
Sbjct: 321 MRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS 380
Query: 405 PVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
++ WLGY NS VNP+IY + EF++AFL++L C
Sbjct: 381 EGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRC 419
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 143 bits (360), Expect = 4e-34
Identities = 74/182 (40%), Positives = 115/182 (63%), Gaps = 5/182 (2%)
Query: 44 LIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS 103
LI V GN+LV ++V+ + L + T+Y IV+LAVADLL+ + V+P+ EV+G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 104 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLS 163
R+ C+I+ +DV+ CTASI+ LC ISIDRY V+ P+ Y T + +R + ++ VW LS
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL-CVWALS 154
Query: 164 FTISCPLLFGLNN---ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR 219
IS LFG D+ C I P +V++S++ SFY+P + L++Y ++Y+V +R
Sbjct: 155 LVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE 214
Query: 220 RK 221
+
Sbjct: 215 SR 216
Score = 76.3 bits (186), Expect = 5e-14
Identities = 41/97 (42%), Positives = 57/97 (58%), Gaps = 4/97 (4%)
Query: 346 MPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFF-ITHILNIHCDCNIP 404
M + KT+T S R L +EKKA + L IV+G F++CWLPFF + I + D
Sbjct: 248 MASAKTKTHF---SVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS 304
Query: 405 PVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
++ WLGY+NS +NPIIY + EF+KAF +L
Sbjct: 305 ETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.137 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,417,648
Number of Sequences: 37866
Number of extensions: 716499
Number of successful extensions: 4995
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 415
Number of HSP's successfully gapped in prelim test: 268
Number of HSP's that attempted gapping in prelim test: 3400
Number of HSP's gapped (non-prelim): 1274
length of query: 443
length of database: 18,247,518
effective HSP length: 105
effective length of query: 338
effective length of database: 14,271,588
effective search space: 4823796744
effective search space used: 4823796744
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.