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Search of human proteins with 4503383
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503383 dopamine receptor D1 [Homo sapiens]
(446 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503383 dopamine receptor D1 [Homo sapiens] 895 0.0
gi|4503391 dopamine receptor D5 [Homo sapiens] 483 e-136
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 229 3e-60
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 228 1e-59
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 219 3e-57
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 219 3e-57
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 219 3e-57
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 219 3e-57
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 219 3e-57
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 219 3e-57
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 214 1e-55
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 207 1e-53
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 207 1e-53
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 207 2e-53
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 207 2e-53
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 207 2e-53
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 207 2e-53
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 204 1e-52
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 204 2e-52
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 202 5e-52
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 201 1e-51
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 195 6e-50
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 191 9e-49
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 187 2e-47
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 187 2e-47
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 187 2e-47
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 182 4e-46
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 177 2e-44
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 176 4e-44
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 172 4e-43
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 895 bits (2313), Expect = 0.0
Identities = 446/446 (100%), Positives = 446/446 (100%)
Query: 1 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN 60
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
Sbjct: 1 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN 60
Query: 61 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD 120
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
Sbjct: 61 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD 120
Query: 121 RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA 180
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
Sbjct: 121 RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA 180
Query: 181 ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN 240
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
Sbjct: 181 ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN 240
Query: 241 CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS 300
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
Sbjct: 241 CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS 300
Query: 301 GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET 360
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
Sbjct: 301 GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET 360
Query: 361 VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL 420
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
Sbjct: 361 VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL 420
Query: 421 SVILDYDTDVSLEKIQPITQNGQHPT 446
SVILDYDTDVSLEKIQPITQNGQHPT
Sbjct: 421 SVILDYDTDVSLEKIQPITQNGQHPT 446
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 483 bits (1242), Expect = e-136
Identities = 261/450 (58%), Positives = 329/450 (73%), Gaps = 40/450 (8%)
Query: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
+++TAC L+LLI+ TLLGN LVCAA++R RHLR+ +TN F++SLAVSDL VA+LVMPWKA
Sbjct: 40 QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
Query: 83 VAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFI 142
VAE+AG+WPFG+FC++WVAFDIMCSTASILNLCVISVDRYWAIS PFRY+RKMT + A +
Sbjct: 100 VAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALV 159
Query: 143 LISVAWTLSVLISFIPVQLSWHKAKPTS------PSD-GNATSLAE-------TIDNCDS 188
++ +AWTLS+LISFIPVQL+WH+ + S P++ N T E +NCDS
Sbjct: 160 MVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDS 219
Query: 189 SLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNG 248
SL+RTYAISSS+ISFYIPVAIMIVTYTRIYRIAQ QIRRI++LERAA HA++C+++
Sbjct: 220 SLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAA-- 277
Query: 249 KPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFC-GSGETQPF- 306
C+ P++S + S K+ETKVLKTLSVIMGVFVCCWLPFFILNC++PFC G E P
Sbjct: 278 ----CA-PDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAG 332
Query: 307 --CIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSIN 364
C+ TFDVFVWFGWANSSLNP+IYAFNADF+K F+ LLGC C T +ETV+I+
Sbjct: 333 FPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRT--PVETVNIS 390
Query: 365 NNGAAMFSSHHEPRGSISKECNLVYLIPHAV--GSSEDLKKEEAAGIARPLE--KLSP-- 418
N + S + + ++++P+AV G+ E EE R + + SP
Sbjct: 391 NE---LISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDG 447
Query: 419 ---ALSV-ILDYDTDVSLEKIQPITQNGQH 444
A SV LD + ++SL+KI P T NG H
Sbjct: 448 DPVAESVWELDCEGEISLDKITPFTPNGFH 477
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 229 bits (585), Expect = 3e-60
Identities = 122/321 (38%), Positives = 191/321 (59%), Gaps = 18/321 (5%)
Query: 30 LSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGF 89
+SL++L+ + GN LV A+ +F L++ VTN+F+ SLA +DL++ + V+P+ A +
Sbjct: 40 MSLIVLAIVFGNVLVITAIAKFERLQT-VTNYFITSLACADLVMGLAVVPFGAAHILMKM 98
Query: 90 WPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAW 148
W FG+F C W + D++C TASI LCVI+VDRY+AI+SPF+Y+ +T A ++I + W
Sbjct: 99 WTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVW 158
Query: 149 TLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVA 208
+S L SF+P+Q+ W++A + A CD ++ YAI+SS++SFY+P+
Sbjct: 159 IVSGLTSFLPIQMHWYRATHQEAINCYANETC-----CDFFTNQAYAIASSIVSFYVPLV 213
Query: 209 IMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRET 268
IM+ Y+R+++ A++Q+++I E H +N +G+ + S F + +E
Sbjct: 214 IMVFVYSRVFQEAKRQLQKIDKSE-GRFHVQNLSQVEQDGRTGHGLRRSSKFCL---KEH 269
Query: 269 KVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNP 328
K LKTL +IMG F CWLPFFI+N + Q I + + W G+ NS NP
Sbjct: 270 KALKTLGIIMGTFTLCWLPFFIVNIV------HVIQDNLIRKEVYILLNWIGYVNSGFNP 323
Query: 329 IIYAFNADFRKAFSTLLGCYR 349
+IY + DFR AF LL C R
Sbjct: 324 LIYCRSPDFRIAFQELL-CLR 343
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 228 bits (580), Expect = 1e-59
Identities = 129/344 (37%), Positives = 190/344 (55%), Gaps = 37/344 (10%)
Query: 30 LSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGF 89
++L++L + GN LV A+ + L++ +TN F++SLA +DL++ +LV+P+ A + G
Sbjct: 65 MALIVLLIVAGNVLVIVAIAKTPRLQT-LTNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
Query: 90 WPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAW 148
W +GSF C +W + D++C TASI LCVI++DRY AI+SPFRY+ +T A L+ W
Sbjct: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVW 183
Query: 149 TLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVA 208
+S L+SF+P+ + W +A+ A CD +R YAI+SSV+SFY+P+
Sbjct: 184 AISALVSFLPILMHWWRAE-----SDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC 238
Query: 209 IMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQP------------ 256
IM Y R++R AQKQ+++I + ER + + + + PV P
Sbjct: 239 IMAFVYLRVFREAQKQVKKIDSCERRFLGGP-ARPPSPSPSPVPAPAPPPGPPRPAAAAA 297
Query: 257 -----------ESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQP 305
++ RE K LKTL +IMGVF CWLPFF+ N + F
Sbjct: 298 TAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF------HR 351
Query: 306 FCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYR 349
+ F F W G+ANS+ NPIIY + DFRKAF LL C R
Sbjct: 352 ELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCAR 395
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 219 bits (559), Expect = 3e-57
Identities = 127/349 (36%), Positives = 190/349 (54%), Gaps = 32/349 (9%)
Query: 5 NTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVI 64
N S+ +G G V +++ FLS +IL +LGN LV AV R LR TN+F++
Sbjct: 7 NVSSEEGFGSVE------KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 60
Query: 65 SLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYW 123
SLA +DLLV+VLVMP+ A+ + W +G FC + + D++ +TASI +LC IS+DRY+
Sbjct: 61 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 120
Query: 124 AI-SSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182
AI P Y KMTP +++ W + ISF+P+ W+ + +
Sbjct: 121 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 180
Query: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQ 242
C +++ YAI+ SV++FYIP +M++ Y RIY A++ +I L+RA ++
Sbjct: 181 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE--- 237
Query: 243 TTTGNGKPVECSQPESSFKMSFKR---ETKVLKTLSVIMGVFVCCWLPFFILNCILPFCG 299
S+P+S+ + S R ETK KTL +IMG F CW PFF+ N + PF
Sbjct: 238 -----------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI- 285
Query: 300 SGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLLGC 347
+ + + F+W G+ NS LNP +YAF N FR+AF +L C
Sbjct: 286 -----DYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 219 bits (559), Expect = 3e-57
Identities = 127/349 (36%), Positives = 190/349 (54%), Gaps = 32/349 (9%)
Query: 5 NTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVI 64
N S+ +G G V +++ FLS +IL +LGN LV AV R LR TN+F++
Sbjct: 7 NVSSEEGFGSVE------KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 60
Query: 65 SLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYW 123
SLA +DLLV+VLVMP+ A+ + W +G FC + + D++ +TASI +LC IS+DRY+
Sbjct: 61 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 120
Query: 124 AI-SSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182
AI P Y KMTP +++ W + ISF+P+ W+ + +
Sbjct: 121 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 180
Query: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQ 242
C +++ YAI+ SV++FYIP +M++ Y RIY A++ +I L+RA ++
Sbjct: 181 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE--- 237
Query: 243 TTTGNGKPVECSQPESSFKMSFKR---ETKVLKTLSVIMGVFVCCWLPFFILNCILPFCG 299
S+P+S+ + S R ETK KTL +IMG F CW PFF+ N + PF
Sbjct: 238 -----------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI- 285
Query: 300 SGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLLGC 347
+ + + F+W G+ NS LNP +YAF N FR+AF +L C
Sbjct: 286 -----DYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 219 bits (559), Expect = 3e-57
Identities = 127/349 (36%), Positives = 190/349 (54%), Gaps = 32/349 (9%)
Query: 5 NTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVI 64
N S+ +G G V +++ FLS +IL +LGN LV AV R LR TN+F++
Sbjct: 7 NVSSEEGFGSVE------KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 60
Query: 65 SLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYW 123
SLA +DLLV+VLVMP+ A+ + W +G FC + + D++ +TASI +LC IS+DRY+
Sbjct: 61 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 120
Query: 124 AI-SSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182
AI P Y KMTP +++ W + ISF+P+ W+ + +
Sbjct: 121 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 180
Query: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQ 242
C +++ YAI+ SV++FYIP +M++ Y RIY A++ +I L+RA ++
Sbjct: 181 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE--- 237
Query: 243 TTTGNGKPVECSQPESSFKMSFKR---ETKVLKTLSVIMGVFVCCWLPFFILNCILPFCG 299
S+P+S+ + S R ETK KTL +IMG F CW PFF+ N + PF
Sbjct: 238 -----------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI- 285
Query: 300 SGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLLGC 347
+ + + F+W G+ NS LNP +YAF N FR+AF +L C
Sbjct: 286 -----DYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 219 bits (559), Expect = 3e-57
Identities = 127/349 (36%), Positives = 190/349 (54%), Gaps = 32/349 (9%)
Query: 5 NTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVI 64
N S+ +G G V +++ FLS +IL +LGN LV AV R LR TN+F++
Sbjct: 7 NVSSEEGFGSVE------KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 60
Query: 65 SLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYW 123
SLA +DLLV+VLVMP+ A+ + W +G FC + + D++ +TASI +LC IS+DRY+
Sbjct: 61 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 120
Query: 124 AI-SSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182
AI P Y KMTP +++ W + ISF+P+ W+ + +
Sbjct: 121 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 180
Query: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQ 242
C +++ YAI+ SV++FYIP +M++ Y RIY A++ +I L+RA ++
Sbjct: 181 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE--- 237
Query: 243 TTTGNGKPVECSQPESSFKMSFKR---ETKVLKTLSVIMGVFVCCWLPFFILNCILPFCG 299
S+P+S+ + S R ETK KTL +IMG F CW PFF+ N + PF
Sbjct: 238 -----------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI- 285
Query: 300 SGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLLGC 347
+ + + F+W G+ NS LNP +YAF N FR+AF +L C
Sbjct: 286 -----DYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 219 bits (559), Expect = 3e-57
Identities = 127/349 (36%), Positives = 190/349 (54%), Gaps = 32/349 (9%)
Query: 5 NTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVI 64
N S+ +G G V +++ FLS +IL +LGN LV AV R LR TN+F++
Sbjct: 7 NVSSEEGFGSVE------KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 60
Query: 65 SLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYW 123
SLA +DLLV+VLVMP+ A+ + W +G FC + + D++ +TASI +LC IS+DRY+
Sbjct: 61 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 120
Query: 124 AI-SSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182
AI P Y KMTP +++ W + ISF+P+ W+ + +
Sbjct: 121 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 180
Query: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQ 242
C +++ YAI+ SV++FYIP +M++ Y RIY A++ +I L+RA ++
Sbjct: 181 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE--- 237
Query: 243 TTTGNGKPVECSQPESSFKMSFKR---ETKVLKTLSVIMGVFVCCWLPFFILNCILPFCG 299
S+P+S+ + S R ETK KTL +IMG F CW PFF+ N + PF
Sbjct: 238 -----------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI- 285
Query: 300 SGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLLGC 347
+ + + F+W G+ NS LNP +YAF N FR+AF +L C
Sbjct: 286 -----DYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 219 bits (559), Expect = 3e-57
Identities = 127/349 (36%), Positives = 190/349 (54%), Gaps = 32/349 (9%)
Query: 5 NTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVI 64
N S+ +G G V +++ FLS +IL +LGN LV AV R LR TN+F++
Sbjct: 7 NVSSEEGFGSVE------KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 60
Query: 65 SLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYW 123
SLA +DLLV+VLVMP+ A+ + W +G FC + + D++ +TASI +LC IS+DRY+
Sbjct: 61 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 120
Query: 124 AI-SSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182
AI P Y KMTP +++ W + ISF+P+ W+ + +
Sbjct: 121 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 180
Query: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQ 242
C +++ YAI+ SV++FYIP +M++ Y RIY A++ +I L+RA ++
Sbjct: 181 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE--- 237
Query: 243 TTTGNGKPVECSQPESSFKMSFKR---ETKVLKTLSVIMGVFVCCWLPFFILNCILPFCG 299
S+P+S+ + S R ETK KTL +IMG F CW PFF+ N + PF
Sbjct: 238 -----------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI- 285
Query: 300 SGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLLGC 347
+ + + F+W G+ NS LNP +YAF N FR+AF +L C
Sbjct: 286 -----DYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 214 bits (546), Expect = 1e-55
Identities = 130/363 (35%), Positives = 195/363 (53%), Gaps = 46/363 (12%)
Query: 5 NTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVI 64
N S+ +G G V +++ FLS +IL +LGN LV AV R LR TN+F++
Sbjct: 7 NVSSEEGFGSVE------KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 60
Query: 65 SLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYW 123
SLA +DLLV+VLVMP+ A+ + W +G FC + + D++ +TASI +LC IS+DRY+
Sbjct: 61 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 120
Query: 124 AI-SSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWH---------KAKPTSPSD 173
AI P Y KMTP +++ W + ISF+P+ W+ D
Sbjct: 121 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQD 180
Query: 174 GNATSLAETIDNCDSS-----LSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI 228
+A + N +S+ +++ YAI+ SV++FYIP +M++ Y RIY A++ +I
Sbjct: 181 FHAIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI 240
Query: 229 AALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKR---ETKVLKTLSVIMGVFVCCW 285
L+RA ++ S+P+S+ + S R ETK KTL +IMG F CW
Sbjct: 241 QMLQRAGASSE--------------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCW 286
Query: 286 LPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTL 344
PFF+ N + PF + + + F+W G+ NS LNP +YAF N FR+AF +
Sbjct: 287 APFFVTNIVDPFI------DYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLII 340
Query: 345 LGC 347
L C
Sbjct: 341 LCC 343
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 207 bits (528), Expect = 1e-53
Identities = 126/367 (34%), Positives = 193/367 (52%), Gaps = 44/367 (11%)
Query: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
+I L++LIL T+ GN +VC AV R LR+ +TN F++SLA++DLL+ +LV+P+ A
Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRN-LTNCFIVSLAITDLLLGLLVLPFSA 76
Query: 83 VAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAF 141
+ +++ W FG FCNI+ + D+M TASILNL +IS+DRY A+ P RY +TP
Sbjct: 77 IYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVA 136
Query: 142 ILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVI 201
I + + W +S+ +SF+ + L W+ TS + T C ++ Y + ++
Sbjct: 137 ISLVLIWVISITLSFLSIHLGWNSRNETSKGN-------HTTSKCKVQVNEVYGLVDGLV 189
Query: 202 SFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFK 261
+FY+P+ IM +TY RI+++A+ Q +RI + SS+K
Sbjct: 190 TFYLPLLIMCITYYRIFKVARDQAKRINHI--------------------------SSWK 223
Query: 262 MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGW 321
+ RE K TL+ +MG F+ CW P+F F G I+ + +W G+
Sbjct: 224 AATIREHKATVTLAAVMGAFIICWFPYF-----TAFVYRGLRGDDAINEVLEAIVLWLGY 278
Query: 322 ANSSLNPIIY-AFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGS 380
ANS+LNPI+Y A N DFR + L C RL A N+ +T +N + EPR
Sbjct: 279 ANSALNPILYAALNRDFRTGYQQLF-CCRL--ANRNSHKTSLRSNASQLSRTQSREPRQQ 335
Query: 381 ISKECNL 387
K L
Sbjct: 336 EEKPLKL 342
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 207 bits (528), Expect = 1e-53
Identities = 126/367 (34%), Positives = 193/367 (52%), Gaps = 44/367 (11%)
Query: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
+I L++LIL T+ GN +VC AV R LR+ +TN F++SLA++DLL+ +LV+P+ A
Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRN-LTNCFIVSLAITDLLLGLLVLPFSA 76
Query: 83 VAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAF 141
+ +++ W FG FCNI+ + D+M TASILNL +IS+DRY A+ P RY +TP
Sbjct: 77 IYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVA 136
Query: 142 ILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVI 201
I + + W +S+ +SF+ + L W+ TS + T C ++ Y + ++
Sbjct: 137 ISLVLIWVISITLSFLSIHLGWNSRNETSKGN-------HTTSKCKVQVNEVYGLVDGLV 189
Query: 202 SFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFK 261
+FY+P+ IM +TY RI+++A+ Q +RI + SS+K
Sbjct: 190 TFYLPLLIMCITYYRIFKVARDQAKRINHI--------------------------SSWK 223
Query: 262 MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGW 321
+ RE K TL+ +MG F+ CW P+F F G I+ + +W G+
Sbjct: 224 AATIREHKATVTLAAVMGAFIICWFPYF-----TAFVYRGLRGDDAINEVLEAIVLWLGY 278
Query: 322 ANSSLNPIIY-AFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGS 380
ANS+LNPI+Y A N DFR + L C RL A N+ +T +N + EPR
Sbjct: 279 ANSALNPILYAALNRDFRTGYQQLF-CCRL--ANRNSHKTSLRSNASQLSRTQSREPRQQ 335
Query: 381 ISKECNL 387
K L
Sbjct: 336 EEKPLKL 342
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 207 bits (527), Expect = 2e-53
Identities = 124/348 (35%), Positives = 190/348 (54%), Gaps = 37/348 (10%)
Query: 19 DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVM 78
+ S IL L LIL +LGN LV +V RHL S VT++++++LAV+DLL+ V+
Sbjct: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVL 80
Query: 79 PWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137
P+ A+ E+ G+W FG FCNIW A D++C TASI+ LC+IS+DRY +S P RY +T
Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
Query: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197
+ + + W LS++IS P+ W + P ETI C + Y +
Sbjct: 141 RRGLMALLCVWALSLVISIGPL-FGWRQPAPED----------ETI--CQINEEPGYVLF 187
Query: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERA----------AVHAKNCQTTTGN 247
S++ SFY+P+AI++V Y R+Y +A+++ R + + + +H KN
Sbjct: 188 SALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN---APAG 244
Query: 248 GKPVECSQPESSFK---MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQ 304
G + ++ ++ F + F RE K KTL +++G FV CWLPFF++ I F
Sbjct: 245 GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-----FP 299
Query: 305 PFCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLC 351
F F + W G+ NS +NPIIY ++ +F+KAF +L LC
Sbjct: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLC 347
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 207 bits (527), Expect = 2e-53
Identities = 124/348 (35%), Positives = 190/348 (54%), Gaps = 37/348 (10%)
Query: 19 DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVM 78
+ S IL L LIL +LGN LV +V RHL S VT++++++LAV+DLL+ V+
Sbjct: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVL 80
Query: 79 PWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137
P+ A+ E+ G+W FG FCNIW A D++C TASI+ LC+IS+DRY +S P RY +T
Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
Query: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197
+ + + W LS++IS P+ W + P ETI C + Y +
Sbjct: 141 RRGLMALLCVWALSLVISIGPL-FGWRQPAPED----------ETI--CQINEEPGYVLF 187
Query: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERA----------AVHAKNCQTTTGN 247
S++ SFY+P+AI++V Y R+Y +A+++ R + + + +H KN
Sbjct: 188 SALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN---APAG 244
Query: 248 GKPVECSQPESSFK---MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQ 304
G + ++ ++ F + F RE K KTL +++G FV CWLPFF++ I F
Sbjct: 245 GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-----FP 299
Query: 305 PFCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLC 351
F F + W G+ NS +NPIIY ++ +F+KAF +L LC
Sbjct: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLC 347
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 207 bits (527), Expect = 2e-53
Identities = 124/348 (35%), Positives = 190/348 (54%), Gaps = 37/348 (10%)
Query: 19 DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVM 78
+ S IL L LIL +LGN LV +V RHL S VT++++++LAV+DLL+ V+
Sbjct: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVL 80
Query: 79 PWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137
P+ A+ E+ G+W FG FCNIW A D++C TASI+ LC+IS+DRY +S P RY +T
Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
Query: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197
+ + + W LS++IS P+ W + P ETI C + Y +
Sbjct: 141 RRGLMALLCVWALSLVISIGPL-FGWRQPAPED----------ETI--CQINEEPGYVLF 187
Query: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERA----------AVHAKNCQTTTGN 247
S++ SFY+P+AI++V Y R+Y +A+++ R + + + +H KN
Sbjct: 188 SALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN---APAG 244
Query: 248 GKPVECSQPESSFK---MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQ 304
G + ++ ++ F + F RE K KTL +++G FV CWLPFF++ I F
Sbjct: 245 GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-----FP 299
Query: 305 PFCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLC 351
F F + W G+ NS +NPIIY ++ +F+KAF +L LC
Sbjct: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLC 347
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 207 bits (527), Expect = 2e-53
Identities = 124/348 (35%), Positives = 190/348 (54%), Gaps = 37/348 (10%)
Query: 19 DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVM 78
+ S IL L LIL +LGN LV +V RHL S VT++++++LAV+DLL+ V+
Sbjct: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVL 80
Query: 79 PWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137
P+ A+ E+ G+W FG FCNIW A D++C TASI+ LC+IS+DRY +S P RY +T
Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
Query: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197
+ + + W LS++IS P+ W + P ETI C + Y +
Sbjct: 141 RRGLMALLCVWALSLVISIGPL-FGWRQPAPED----------ETI--CQINEEPGYVLF 187
Query: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERA----------AVHAKNCQTTTGN 247
S++ SFY+P+AI++V Y R+Y +A+++ R + + + +H KN
Sbjct: 188 SALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN---APAG 244
Query: 248 GKPVECSQPESSFK---MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQ 304
G + ++ ++ F + F RE K KTL +++G FV CWLPFF++ I F
Sbjct: 245 GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-----FP 299
Query: 305 PFCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLC 351
F F + W G+ NS +NPIIY ++ +F+KAF +L LC
Sbjct: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLC 347
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 204 bits (520), Expect = 1e-52
Identities = 127/353 (35%), Positives = 185/353 (52%), Gaps = 47/353 (13%)
Query: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
++L L+L+ L+T L N V A V R R L + N+ + SLAV+DLLV++LVMP
Sbjct: 49 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPA-NYLIASLAVTDLLVSILVMPIST 107
Query: 83 VAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAF 141
+ + G W G C+ W++ DI C TASIL+LCVI++DRYWAI+ Y K TPK A
Sbjct: 108 MYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAA 167
Query: 142 ILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVI 201
++I++ W S+ IS P W +AK ++E + N D L Y + S+V
Sbjct: 168 VMIALVWVFSISISLPP--FFWRQAKAEE-------EVSECVVNTDHIL---YTVYSTVG 215
Query: 202 SFYIPVAIMIVTYTRIYRIAQKQI------RRIAALERA--------------AVHAKNC 241
+FY P ++I Y RIY A+ +I R L RA +++++
Sbjct: 216 AFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVP 275
Query: 242 QTTTGNGKPVECSQPE--------SSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNC 293
+ +G PV +Q + K+ RE K KTL +I+G F+ CWLPFFI++
Sbjct: 276 DVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISL 335
Query: 294 ILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLL 345
++P C I FD F W G+ NS +NPIIY N DF++AF L+
Sbjct: 336 VMPICKDACWFHLAI----FDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 204 bits (518), Expect = 2e-52
Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 36/400 (9%)
Query: 27 ACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEI 86
A L ++I T N+L+ A + LR+ +NFF++SL SDL+V ++VMP + +
Sbjct: 30 AAALCVVIALTAAANSLLIALICTQPALRN-TSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
Query: 87 AGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILIS 145
G W C +W AFD+MC +ASILNLC+IS+DRY I SP RY+ +MTP A L+
Sbjct: 89 YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVL 148
Query: 146 VAWTLSVLISFIPVQLSWHK---AKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVIS 202
AW+L+ L SF+P+ L WH+ A+P P C S + + +S ++
Sbjct: 149 GAWSLAALASFLPLLLGWHELGHARPPVPG------------QCRLLASLPFVLVASGLT 196
Query: 203 FYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKM 262
F++P + TY RI A+KQ ++A+L + ++ +T P + S ++
Sbjct: 197 FFLPSGAICFTYCRILLAARKQAVQVASL-TTGMASQASETLQVPRTPRPGVESADSRRL 255
Query: 263 SFKRETKVLK---TLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWF 319
+ K K LK TL +++G+F WLPFF+ N + C CI FDV W
Sbjct: 256 ATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCD-------CISPGLFDVLTWL 308
Query: 320 GWANSSLNPIIY-AFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPR 378
G+ NS++NPIIY F DF++A L C R CP A + ++ +SH PR
Sbjct: 309 GYCNSTMNPIIYPLFMRDFKRALGRFLPCPR-CPRERQA------SLASPSLRTSHSGPR 361
Query: 379 GSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSP 418
+S + L +P S D ++G+ + L P
Sbjct: 362 PGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLP 401
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 202 bits (514), Expect = 5e-52
Identities = 124/345 (35%), Positives = 190/345 (55%), Gaps = 36/345 (10%)
Query: 19 DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVM 78
D + I L IL ++GN LV +V RHLR+ TN+F+++LA++DLL++ V+
Sbjct: 41 DITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTP-TNYFIVNLAMADLLLSFTVL 99
Query: 79 PWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137
P+ A E+ G+W G FC+IW A D++C TASIL+LC IS+DRY + +Y +T
Sbjct: 100 PFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTR 159
Query: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197
+ A + + W LS +IS P+ L W K +P+D C + YA+
Sbjct: 160 RKAILALLSVWVLSTVISIGPL-LGW---KEPAPNDDK---------ECGVTEEPFYALF 206
Query: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAA--LERAA--------VHAKNCQTTTGN 247
SS+ SFYIP+A+++V Y R+Y +A++ + + A ++ + +H+KN T +
Sbjct: 207 SSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLS 266
Query: 248 GKPVECSQPESSFKM---SFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGET- 303
+ P SS + F RE K KTL +++G+F+ CWLPFFI LP T
Sbjct: 267 STKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFI---ALPLGSLFSTL 323
Query: 304 QPFCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGC 347
+P F V W G+ NS LNPIIY ++ +F++AF +LGC
Sbjct: 324 KP---PDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 201 bits (510), Expect = 1e-51
Identities = 122/338 (36%), Positives = 186/338 (55%), Gaps = 39/338 (11%)
Query: 29 FLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 88
FL+ IL + GN LV +V RHL++ VTN+F+++LAV+DLL++ V+P+ A E+ G
Sbjct: 102 FLAAFILMAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATVLPFSATMEVLG 160
Query: 89 FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVA 147
FW FG +FC++W A D++C TASIL+LC ISVDRY + +Y MT + A ++++
Sbjct: 161 FWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALL 220
Query: 148 WTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPV 207
W +++++S P+ L W K P D + E YA+ SSV SFY+P+
Sbjct: 221 WVVALVVSVGPL-LGW---KEPVPPDERFCGITE---------EAGYAVFSSVCSFYLPM 267
Query: 208 AIMIVTYTRIYRIAQKQIRRIAA---LERA-------AVHAKNCQTTTGNGKPVECSQPE 257
A+++V Y R+Y +A+ R + A ER +H + T + ++
Sbjct: 268 AVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGH 327
Query: 258 ------SSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDS- 310
S + F RE K KTL++++GVFV CW PFF +LP G P S
Sbjct: 328 TFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFF---VLPL---GSLFPQLKPSE 381
Query: 311 NTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGC 347
F V W G+ NS +NP+IY ++ +F++AF LL C
Sbjct: 382 GVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRC 419
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 195 bits (496), Expect = 6e-50
Identities = 124/359 (34%), Positives = 185/359 (51%), Gaps = 57/359 (15%)
Query: 21 SVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPW 80
+++I A LS++ L+T+L N V ++ R L + N+ + SLA +DLLV++LVMP
Sbjct: 36 ALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPA-NYLIGSLATTDLLVSILVMPI 94
Query: 81 KAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKA 139
I W FG C+IW++ DI C TASIL+LCVI++DRYWAI+ Y ++ T
Sbjct: 95 SIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGH 154
Query: 140 AFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSR-TYAISS 198
A +I++ W +S+ IS P L W +AK E + +C + S+ +Y I S
Sbjct: 155 AATMIAIVWAISICISIPP--LFWRQAK-----------AQEEMSDCLVNTSQISYTIYS 201
Query: 199 SVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTT---TGNGKPVECSQ 255
+ +FYIP ++I+ Y RIYR A+ +I L +++ K T TG+ CS
Sbjct: 202 TCGAFYIPSVLLIILYGRIYRAARNRI-----LNPPSLYGKRFTTAHLITGSAGSSLCSL 256
Query: 256 PESSF----------------------------KMSFKRETKVLKTLSVIMGVFVCCWLP 287
S ++S RE K K L +I+G F+ CWLP
Sbjct: 257 NSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLP 316
Query: 288 FFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIY-AFNADFRKAFSTLL 345
FF+++ +LP C I FD F W G+ NS +NPIIY FN +FR+AF ++
Sbjct: 317 FFVVSLVLPIC----RDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 191 bits (486), Expect = 9e-49
Identities = 126/392 (32%), Positives = 190/392 (48%), Gaps = 36/392 (9%)
Query: 3 TLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFF 62
T NTS + G L L+L +L+T+ GN LV A+ L++ +TN F
Sbjct: 24 TANTSGLPGVPWEAA-------LAGALLALAVLATVGGNLLVIVAIAWTPRLQT-MTNVF 75
Query: 63 VISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDR 121
V SLA +DL++ +LV+P A + G WP G+ C +W + D++C TASI LC ++VDR
Sbjct: 76 VTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDR 135
Query: 122 YWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAE 181
Y A+++P RY +T + A + + W +S +SF P+ W + +D A
Sbjct: 136 YLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV----GADAEAQRCHS 191
Query: 182 TIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI------------- 228
C + + Y + SS +SFY+P+ +M+ Y R++ +A +Q+R +
Sbjct: 192 NPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESP 251
Query: 229 AALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPF 288
A R+ A G P +P + RE + L TL +IMG F CWLPF
Sbjct: 252 PAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPL---REHRALCTLGLIMGTFTLCWLPF 308
Query: 289 FILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLL-GC 347
F+ N + G P + F W G+ANS+ NP+IY + DFR AF LL C
Sbjct: 309 FLANVLRALGG-----PSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRC 363
Query: 348 YRLCPATNNAIETVSINNNGA-AMFSSHHEPR 378
R P A ++ +G A SS +PR
Sbjct: 364 GRRLPPEPCAAARPALFPSGVPAARSSPAQPR 395
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 187 bits (474), Expect = 2e-47
Identities = 121/345 (35%), Positives = 179/345 (51%), Gaps = 44/345 (12%)
Query: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
+++ L+L+ L T+ GN LV +V + LR +N+ ++SLA++DL VAV VMP+ +
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQP-SNYLIVSLALADLSVAVAVMPFVS 139
Query: 83 VAE-IAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAA 140
V + I G W FG F CN+++A D+MC TASI+ LCVIS+DRY I+ P Y + K
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 141 FILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDN---CDSSLSRTYAIS 197
+I W LS I+ +P W A+ +++ C S Y I
Sbjct: 200 AKMILSVWLLSASIT-LPPLFGW----------------AQNVNDDKVCLISQDFGYTIY 242
Query: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRR-------------IAALERAAVHAKNCQTT 244
S+ ++FYIP+++M+ Y +IY+ A+K + + AL K +
Sbjct: 243 STAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEEC 302
Query: 245 TGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPF-CGSGET 303
+ ++ + S FKRE K TL +I+G F CWLPFF+L+ PF CG T
Sbjct: 303 ANLSRLLKHERKNISI---FKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG---T 356
Query: 304 QPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGC 347
CI F+W G+ANS +NP IYA FN D R + +LL C
Sbjct: 357 SCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 187 bits (474), Expect = 2e-47
Identities = 121/345 (35%), Positives = 179/345 (51%), Gaps = 44/345 (12%)
Query: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
+++ L+L+ L T+ GN LV +V + LR +N+ ++SLA++DL VAV VMP+ +
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQP-SNYLIVSLALADLSVAVAVMPFVS 139
Query: 83 VAE-IAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAA 140
V + I G W FG F CN+++A D+MC TASI+ LCVIS+DRY I+ P Y + K
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 141 FILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDN---CDSSLSRTYAIS 197
+I W LS I+ +P W A+ +++ C S Y I
Sbjct: 200 AKMILSVWLLSASIT-LPPLFGW----------------AQNVNDDKVCLISQDFGYTIY 242
Query: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRR-------------IAALERAAVHAKNCQTT 244
S+ ++FYIP+++M+ Y +IY+ A+K + + AL K +
Sbjct: 243 STAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEEC 302
Query: 245 TGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPF-CGSGET 303
+ ++ + S FKRE K TL +I+G F CWLPFF+L+ PF CG T
Sbjct: 303 ANLSRLLKHERKNISI---FKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG---T 356
Query: 304 QPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGC 347
CI F+W G+ANS +NP IYA FN D R + +LL C
Sbjct: 357 SCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 187 bits (474), Expect = 2e-47
Identities = 121/345 (35%), Positives = 179/345 (51%), Gaps = 44/345 (12%)
Query: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82
+++ L+L+ L T+ GN LV +V + LR +N+ ++SLA++DL VAV VMP+ +
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQP-SNYLIVSLALADLSVAVAVMPFVS 139
Query: 83 VAE-IAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAA 140
V + I G W FG F CN+++A D+MC TASI+ LCVIS+DRY I+ P Y + K
Sbjct: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Query: 141 FILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDN---CDSSLSRTYAIS 197
+I W LS I+ +P W A+ +++ C S Y I
Sbjct: 200 AKMILSVWLLSASIT-LPPLFGW----------------AQNVNDDKVCLISQDFGYTIY 242
Query: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRR-------------IAALERAAVHAKNCQTT 244
S+ ++FYIP+++M+ Y +IY+ A+K + + AL K +
Sbjct: 243 STAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEEC 302
Query: 245 TGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPF-CGSGET 303
+ ++ + S FKRE K TL +I+G F CWLPFF+L+ PF CG T
Sbjct: 303 ANLSRLLKHERKNISI---FKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG---T 356
Query: 304 QPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGC 347
CI F+W G+ANS +NP IYA FN D R + +LL C
Sbjct: 357 SCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 182 bits (463), Expect = 4e-46
Identities = 138/385 (35%), Positives = 191/385 (49%), Gaps = 59/385 (15%)
Query: 1 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN 60
M LN+S + T + +IL + LS L L T N+LV AA+I R L N
Sbjct: 1 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPA-N 59
Query: 61 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISV 119
+ + SLAV+D LVAVLVMP+ V + W G C+IW++ DI C T SIL+L I++
Sbjct: 60 YLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIAL 119
Query: 120 DRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSL 179
DRY AI+ Y RK TPK A I+I++ W +SV IS P L W + + TS D
Sbjct: 120 DRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPP--LFW-RHQGTSRDD------ 170
Query: 180 AETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIA-----QKQIRRIA----- 229
E I D +S Y S+ +FYIP+A++++ Y +IYR A ++Q RIA
Sbjct: 171 -ECIIKHDHIVSTIY---STFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVN 226
Query: 230 ---ALERAAVHAKNCQTTTGNGKPVECSQPESSF-----------------------KMS 263
LE K+ T+ K + S P + F K+S
Sbjct: 227 GQVLLESGEKSTKSVSTSYVLEKSL--SDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKIS 284
Query: 264 FKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWAN 323
RE K TL +I+G FV CWLPFF+ ++ C + I + W G+ N
Sbjct: 285 GTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCK-----ISEEMSNFLAWLGYLN 339
Query: 324 SSLNPIIYA-FNADFRKAFSTLLGC 347
S +NP+IY FN DF+KAF L+ C
Sbjct: 340 SLINPLIYTIFNEDFKKAFQKLVRC 364
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 177 bits (448), Expect = 2e-44
Identities = 125/377 (33%), Positives = 187/377 (49%), Gaps = 63/377 (16%)
Query: 8 AMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLA 67
A + TG R + L+ C LIL+ + GN LVC AV++ R L++ TN+ V+SLA
Sbjct: 17 AENSTGASQARPHAYYALSYC---ALILAIVFGNGLVCMAVLKERALQT-TTNYLVVSLA 72
Query: 68 VSDLLVAVLVMPWKAVAEIAG-FWPFGSFC-NIWVAFDIMCSTASILNLCVISVDRYWAI 125
V+DLLVA LVMPW E+ G W F C +++V D+M TASILNLC IS+DRY A+
Sbjct: 73 VADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV 132
Query: 126 SSPFRYER---KMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182
P Y+ + + + ++I+ W L+ +S P+ ++ + G+ T +
Sbjct: 133 VMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS-CPLLFGFN-------TTGDPTVC--S 182
Query: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN-- 240
I N D + I SSV+SFY+P + ++ Y RIY + KQ RR L R +
Sbjct: 183 ISNPD------FVIYSSVVSFYLPFGVTVLVYARIY-VVLKQRRRKRILTRQNSQCNSVR 235
Query: 241 -----------------------CQTTTGNG-----KPVECSQPESSFKMSFK-RETKVL 271
CQ T G + E + E + RE K
Sbjct: 236 PGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKAT 295
Query: 272 KTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIY 331
+ +++++G F+ CWLPFF+ + + C + P + T W G+ NS+LNP+IY
Sbjct: 296 QMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATT-----WLGYVNSALNPVIY 350
Query: 332 -AFNADFRKAFSTLLGC 347
FN +FRKAF +L C
Sbjct: 351 TTFNIEFRKAFLKILSC 367
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 176 bits (446), Expect = 4e-44
Identities = 112/354 (31%), Positives = 176/354 (49%), Gaps = 55/354 (15%)
Query: 30 LSLLILSTLLGNTLVCAAVIRFRHLRSKV---TNFFVISLAVSDLLVAVLVMPWKAVAEI 86
++L++++TL TL+ AVI K+ N+ + SLAV+DLLVAVLVMP + +
Sbjct: 27 MTLVVITTL--TTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIV 84
Query: 87 AGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILIS 145
W G F C +W++ D+ C T SIL+LCVI++DRYWAI++ Y RK T K A ++I
Sbjct: 85 MDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMIL 144
Query: 146 VAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYI 205
WT+S+ IS P L W + SP T + + Y I S++ +FYI
Sbjct: 145 TVWTISIFISMPP--LFWRSHRRLSPPPSQCTIQHDHV---------IYTIYSTLGAFYI 193
Query: 206 PVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVE--------CSQPE 257
P+ ++++ Y RIY A+ ++ + + + + Q + + K + S P
Sbjct: 194 PLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT 253
Query: 258 SSF-----------------------KMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCI 294
+ F ++S RE K + L +I+G F+ WLPFFI I
Sbjct: 254 TEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELI 313
Query: 295 LPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIY-AFNADFRKAFSTLLGC 347
+ + + S D W G+ NS +NP++Y +FN DF+ AF L+ C
Sbjct: 314 VGL------SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 172 bits (437), Expect = 4e-43
Identities = 107/333 (32%), Positives = 170/333 (51%), Gaps = 33/333 (9%)
Query: 20 FSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMP 79
F V ILT L L+ +T N LV A ++R R +V + V S+AVSD+LVA LVMP
Sbjct: 39 FGVLILT--LLGFLVAATFAWNLLVLATILRVRTFH-RVPHNLVASMAVSDVLVAALVMP 95
Query: 80 WKAVAEIAGF-WPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137
V E++G W G C +W+A D++C TASI N+ I++DRYW+I+ Y +
Sbjct: 96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRK 155
Query: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197
+ ++I++ W LS +IS P+ W + +E + C S +YA+
Sbjct: 156 CVSNVMIALTWALSAVISLAPLLFGW------------GETYSEGSEECQVSREPSYAVF 203
Query: 198 SSVISFYIPVAIMIVTYTRIY-----RIAQKQIRRIAALERAAV---HAKNCQTTTGNGK 249
S+V +FY+P+ +++ Y +IY R+ ++ ++ + A AK Q
Sbjct: 204 STVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRH 263
Query: 250 PVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCID 309
QPE ++E + + +++GVFV CW+PFF+ I P C I
Sbjct: 264 ATVTFQPEGD-TWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD------IP 316
Query: 310 SNTFDVFVWFGWANSSLNPIIY-AFNADFRKAF 341
+ +F+W G++NS NP+IY AFN ++ AF
Sbjct: 317 AIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.135 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,613,481
Number of Sequences: 37866
Number of extensions: 638906
Number of successful extensions: 3726
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 415
Number of HSP's successfully gapped in prelim test: 245
Number of HSP's that attempted gapping in prelim test: 2276
Number of HSP's gapped (non-prelim): 935
length of query: 446
length of database: 18,247,518
effective HSP length: 105
effective length of query: 341
effective length of database: 14,271,588
effective search space: 4866611508
effective search space used: 4866611508
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.