Search of human proteins with 4503301

Search of human proteins with 4503301

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
         (335 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]       664   0.0  
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]    157   1e-38
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                154   8e-38
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...   102   5e-22
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    88   9e-18
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           87   2e-17
gi|40254992 carbonic reductase 4 [Homo sapiens]                        85   8e-17
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              79   7e-15
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    67   3e-11
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   65   1e-10
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     63   3e-10
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    63   4e-10
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    62   7e-10
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...    61   1e-09
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            58   1e-08
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo...    58   1e-08
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ...    58   1e-08
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...    56   4e-08
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    54   2e-07
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    54   3e-07
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     52   7e-07
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    52   7e-07
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           51   1e-06
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    50   2e-06
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    50   2e-06
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    49   5e-06
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    49   5e-06
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    49   5e-06
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]     49   6e-06
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ...    49   6e-06

>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score =  664 bits (1713), Expect = 0.0
 Identities = 335/335 (100%), Positives = 335/335 (100%)

Query: 1   MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGK 60
           MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGK
Sbjct: 1   MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGK 60

Query: 61  VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRD 120
           VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRD
Sbjct: 61  VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRD 120

Query: 121 PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIG 180
           PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIG
Sbjct: 121 PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIG 180

Query: 181 KQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQP 240
           KQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQP
Sbjct: 181 KQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQP 240

Query: 241 GPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFD 300
           GPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFD
Sbjct: 241 GPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFD 300

Query: 301 GGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS 335
           GGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
Sbjct: 301 GGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS 335


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score =  157 bits (397), Expect = 1e-38
 Identities = 92/264 (34%), Positives = 142/264 (53%), Gaps = 11/264 (4%)

Query: 49  KAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQ-- 106
           ++ L P   QG+VA +TGG TG+GK +   L  LG+  VIASRK++ LK+ A+++ +   
Sbjct: 8   RSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLP 67

Query: 107 --TGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTI 164
                +V  IQC++R+ + V N V   +   G  N ++NN  G F+SP E +S   W  +
Sbjct: 68  PTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAV 127

Query: 165 TDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGF--VVPSASAKAGVEAMSK 222
            +  L GT ++   +    +K   G    SI  I   T +GF   V S +A+AGV  ++K
Sbjct: 128 LETNLTGTFYMCKAVYSSWMKEHGG----SIVNIIVPTKAGFPLAVHSGAARAGVYNLTK 183

Query: 223 SLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTG-TFEKEMIGRIPCGRLGTVEELANLA 281
           SLA EW   G+R N + PG I ++ A       G +F +    +IP  R+G  EE++++ 
Sbjct: 184 SLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVV 243

Query: 282 AFLCSDYASWINGAVIKFDGGEEV 305
            FL S  AS+I G  +  DGG  +
Sbjct: 244 CFLLSPAASFITGQSVDVDGGRSL 267


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score =  154 bits (390), Expect = 8e-38
 Identities = 91/257 (35%), Positives = 134/257 (52%), Gaps = 1/257 (0%)

Query: 46  PLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISS 105
           P  + +  P+  + KVAFITGGG+G+G  +  +    G   VIASR +  +   A +++ 
Sbjct: 15  PAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG 74

Query: 106 QTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTIT 165
            TG +   +  DVR P  V   V + +K  G  +I+IN AAGNF+ P   LS NA+KT+ 
Sbjct: 75  ATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVM 134

Query: 166 DIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLA 225
           DI  +GT  V+  + ++  +   G   ++IT      G    V + SAKA V+AM++ LA
Sbjct: 135 DIDTSGTFNVSRVLYEKFFR-DHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLA 193

Query: 226 AEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLC 285
            EWG   +R N + PGPI       RL          +   P  RLG   E+A+   +L 
Sbjct: 194 VEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLA 253

Query: 286 SDYASWINGAVIKFDGG 302
           S  AS++ GAV+  DGG
Sbjct: 254 SPLASYVTGAVLVADGG 270


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score =  102 bits (254), Expect = 5e-22
 Identities = 79/255 (30%), Positives = 124/255 (48%), Gaps = 16/255 (6%)

Query: 57  FQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQC 116
           + GKV  +TGGG G+G G+     + GA+ VI  +     +A  +++          I C
Sbjct: 7   YAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-----FILC 61

Query: 117 DVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPT--ERLSPNAWKTITDIVLNGTAF 174
           DV   D V+  VSE I+  G  + V+NNA G+   P   E  S   ++ + ++ L GT  
Sbjct: 62  DVTQEDDVKTLVSETIRRFGRLDCVVNNA-GHHPPPQRPEETSAQGFRQLLELNLLGTYT 120

Query: 175 VTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMR 234
           +T      L K+Q     ++I+++    G    VP  + K  V AM+K+LA +   YG+R
Sbjct: 121 LTKLALPYLRKSQGNV--INISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVR 178

Query: 235 FNVIQPG----PIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYAS 290
            N I PG    P+  + A    DP  T  + M+ + P GR+G   E+   A FL S+ A+
Sbjct: 179 VNCISPGNIWTPLWEELAALMPDPRATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-AN 236

Query: 291 WINGAVIKFDGGEEV 305
           +  G  +   GG E+
Sbjct: 237 FCTGIELLVTGGAEL 251


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 88.2 bits (217), Expect = 9e-18
 Identities = 70/245 (28%), Positives = 118/245 (48%), Gaps = 6/245 (2%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
           KVA +T    G+G  +   L+  GA  V++SRK   +      +  + G  V    C V 
Sbjct: 33  KVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGE-GLSVTGTVCHVG 91

Query: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGN-FISPTERLSPNAWKTITDIVLNGTAFVTLE 178
             +  +  V+  +K+ G  +I+++NAA N F      ++   W    DI +   A +T  
Sbjct: 92  KAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKA 151

Query: 179 IGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238
           +  ++ K + G + + +++I A + S    P   +K  +  ++K+LA E     +R N +
Sbjct: 152 VVPEMEK-RGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCL 210

Query: 239 QPGPIKTKGAFSR-LDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVI 297
            PG IKT  +FSR L      E+ M   +   RLG  E+ A + +FLCS+ AS+I G  +
Sbjct: 211 APGLIKT--SFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETV 268

Query: 298 KFDGG 302
              GG
Sbjct: 269 VVGGG 273


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 67/258 (25%), Positives = 123/258 (47%), Gaps = 16/258 (6%)

Query: 55  NSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVI-------ASRKMDVLKATAEQISSQT 107
           N  +  +A +TG G+G+G+ ++  L+  GA           A   + +L     +     
Sbjct: 7   NRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPR 66

Query: 108 GNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTE---RLSPNAWKTI 164
           GN   A Q DV +    +  + ++      P  V+ + AG  I+  E    +S + W  +
Sbjct: 67  GNHA-AFQADVSEARAARCLLEQVQACFSRPPSVVVSCAG--ITQDEFLLHMSEDDWDKV 123

Query: 165 TDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSL 224
             + L GT  VT    + L+      + ++I++I  + G+      A++KAGV  ++++ 
Sbjct: 124 IAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTA 183

Query: 225 AAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFL 284
           A E G++G+R N + PG I T    ++  P    +K +   IP G LG  E++A++ AFL
Sbjct: 184 ARELGRHGIRCNSVLPGFIAT--PMTQKVPQKVVDK-ITEMIPMGHLGDPEDVADVVAFL 240

Query: 285 CSDYASWINGAVIKFDGG 302
            S+ + +I G  ++  GG
Sbjct: 241 ASEDSGYITGTSVEVTGG 258


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 85.1 bits (209), Expect = 8e-17
 Identities = 73/250 (29%), Positives = 118/250 (47%), Gaps = 17/250 (6%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
           KV  + GG  G+G+ +  L++  G +  + +R ++  KA A  +    G    A  CDV 
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDL----GGDHLAFSCDVA 58

Query: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEI 179
               VQNT  EL K  G  N ++N A  N      R       +     L G+  +T + 
Sbjct: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGS-MLTCKA 117

Query: 180 GKQLIKAQKGAAFLSITTIYAETG-SGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238
             + +  Q+G + +++ +I    G SG  V SAS K G+   S++LA E  +  +R NV+
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSAS-KGGLVGFSRALAKEVARKKIRVNVV 176

Query: 239 QPGPIKTKGAFSRLDPTGTFEKEMIGR-IPCGRLGTVEELANLAAFLCSDYASWINGAVI 297
            PG       F   D T   ++E + + IP GR G   E+A+   FL    + +I G V+
Sbjct: 177 APG-------FVHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLE--SPYITGHVL 227

Query: 298 KFDGGEEVLI 307
             DGG ++++
Sbjct: 228 VVDGGLQLIL 237


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 78.6 bits (192), Expect = 7e-15
 Identities = 57/245 (23%), Positives = 109/245 (44%), Gaps = 12/245 (4%)

Query: 59  GKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDV 118
           G+   +TG G G+G+G    L + GA+ V  SR    L +   +        +  +  D+
Sbjct: 7   GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----IEPVCVDL 61

Query: 119 RDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLE 178
            D +  +  +  +    G  ++++NNAA   + P   ++  A+    ++ L     V+  
Sbjct: 62  GDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117

Query: 179 IGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238
           + + LI      A +++++  ++          S K  ++ ++K +A E G + +R N +
Sbjct: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177

Query: 239 QPGPIKTK-GAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVI 297
            P  + T  G  +  DP     K M+ RIP G+   VE + N   FL SD +    G+ +
Sbjct: 178 NPTVVMTSMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235

Query: 298 KFDGG 302
             +GG
Sbjct: 236 PVEGG 240


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 64/246 (26%), Positives = 111/246 (45%), Gaps = 11/246 (4%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
           +VA +TG  +G+G  +   L+  GA  VI+SRK   +     ++  + G  V  I C V 
Sbjct: 37  RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGE-GLSVAGIVCHVG 95

Query: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGN-FISPTERLSPNAWKTITDIVLNGTAFVTLE 178
             +  +  V++ ++  G  + ++ +A  N  +  T   S   W  I  + +   A +  +
Sbjct: 96  KAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQ 155

Query: 179 IGKQLIKAQKGAAFL--SITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFN 236
           +    ++ ++GA  L  SI         G    S +A  G   ++++LA E     +R N
Sbjct: 156 L-LPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLG---LTRTLALELAPKDIRVN 211

Query: 237 VIQPGPIKTKGAFSRL-DPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGA 295
            + PG IKT   FS++     +  K         R+G  E+ A + +FLCS  AS++NG 
Sbjct: 212 CVVPGIIKTD--FSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGE 269

Query: 296 VIKFDG 301
            I   G
Sbjct: 270 NIAVAG 275


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 16/192 (8%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
           K  FITG  +G GK +   L + G + + A     + +  AEQ+  QT +++  +  DV 
Sbjct: 30  KYVFITGCDSGFGKLLARQLDARGLRVLAAC----LTEKGAEQLRGQTSDRLETVTLDVT 85

Query: 120 DPDMVQNT---VSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVT 176
             + V      V E ++  G   +V N       +P E L+   + TI D+ L G   VT
Sbjct: 86  KTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVT 145

Query: 177 LEIGKQLIKAQKGAAFLSITTIYAET---GSGFVVPSASAKAGVEAMSKSLAAEWGKYGM 233
           L +   L++  +G   ++++++       G G+ +    +K GVEA S SL  E   +G+
Sbjct: 146 LSL-LPLVRRARGRV-VNVSSVMGRVSLFGGGYCI----SKYGVEAFSDSLRRELSYFGV 199

Query: 234 RFNVIQPGPIKT 245
           +  +I+PG  KT
Sbjct: 200 KVAMIEPGYFKT 211


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 61/250 (24%), Positives = 118/250 (47%), Gaps = 19/250 (7%)

Query: 59  GKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDV 118
           GKV  +T    G+G+      +  GA+ VIA+   D+ ++  +++    G +   +  DV
Sbjct: 6   GKVIILTAAAQGIGQAAALAFAREGAK-VIAT---DINESKLQELEKYPGIQTRVL--DV 59

Query: 119 RDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLN-GTAFVTL 177
                +    +E+ ++      V+ N AG F+     L          + LN  + ++ +
Sbjct: 60  TKKKQIDQFANEVERLD-----VLFNVAG-FVHHGTVLDCEEKDWDFSMNLNVRSMYLMI 113

Query: 178 EIGKQLIKAQKGAAFLSITTIYAETGSGFV--VPSASAKAGVEAMSKSLAAEWGKYGMRF 235
           +     + AQK    ++++++ A +  G V     ++ KA V  ++KS+AA++ + G+R 
Sbjct: 114 KAFLPKMLAQKSGNIINMSSV-ASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRC 172

Query: 236 NVIQPGPIKTKGAFSRLDPTGTFEK---EMIGRIPCGRLGTVEELANLAAFLCSDYASWI 292
           N + PG + T     R+   G  E+   + + R   GR  T EE+A L  +L SD ++++
Sbjct: 173 NCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYV 232

Query: 293 NGAVIKFDGG 302
            G  +  DGG
Sbjct: 233 TGNPVIIDGG 242


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 53/189 (28%), Positives = 92/189 (48%), Gaps = 16/189 (8%)

Query: 63  FITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPD 122
           FITG  +G G+ +   L   G + V+AS    +  + AE +     +++H    D+ DP 
Sbjct: 32  FITGCDSGFGRLLALQLDQRGFR-VLASC---LTPSGAEDLQRVASSRLHTTLLDITDPQ 87

Query: 123 MVQNT---VSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEI 179
            VQ     V   +K AG   +V N      I PT  L+ + ++ + ++   G   VTL +
Sbjct: 88  SVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLAL 147

Query: 180 GKQLIKAQKGAAFLSITTIY---AETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFN 236
              L +A+     ++IT++    A  G G+ V    +K G+EA S SL  +   +G+R +
Sbjct: 148 LPLLQQAR--GRVINITSVLGRLAANGGGYCV----SKFGLEAFSDSLRRDVAHFGIRVS 201

Query: 237 VIQPGPIKT 245
           +++PG  +T
Sbjct: 202 IVEPGFFRT 210


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 46/202 (22%), Positives = 93/202 (46%), Gaps = 6/202 (2%)

Query: 61  VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKV-----HAIQ 115
           V  ITG  +GLGK    +  + GA+ V+  R    L+    ++++    KV     + + 
Sbjct: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113

Query: 116 CDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFV 175
            D+ D   +    +E+++  G+ +I++NNA  ++       + +  K + +    G   +
Sbjct: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVAL 173

Query: 176 TLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRF 235
           T  +   +IK ++G   ++I++I  +    F    A++K   +A    L AE  +Y +  
Sbjct: 174 TKALLPSMIKRRQG-HIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEV 232

Query: 236 NVIQPGPIKTKGAFSRLDPTGT 257
            VI PG I T  + + +   G+
Sbjct: 233 TVISPGYIHTNLSVNAITADGS 254


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 62/248 (25%), Positives = 104/248 (41%), Gaps = 9/248 (3%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
           KVA +T     +G  +   L+  GA  V++ RK   +      +  + G  +    C V 
Sbjct: 33  KVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGE-GLSMTGTVCHVG 91

Query: 120 DPDMVQNTVSELIKVAGHPNI----VINNAAGNFISPTERLSPNAWKTITDIVLNGTAFV 175
                +  V+  +K+ G  +I    + N+  G F     + +  AW    DI     A +
Sbjct: 92  KMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALALM 151

Query: 176 TLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRF 235
              +  ++ K   G+     +        GF  P   +K  +  ++K+LA E     +R 
Sbjct: 152 IKAVVPEMEKRGGGSVGFLASVAAFRPLPGFS-PYNVSKTALLGLNKTLAIELAPRNIRV 210

Query: 236 NVIQPGPIKTKGAFSR-LDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWING 294
           N + PG IKT  +FSR L      E+ M   +   RLG  E+   + +FLCS+ AS++ G
Sbjct: 211 NCLAPGLIKT--SFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDASYLTG 268

Query: 295 AVIKFDGG 302
             +   GG
Sbjct: 269 ETVMVGGG 276


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 54/197 (27%), Positives = 90/197 (45%), Gaps = 8/197 (4%)

Query: 54  PNSF---QGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNK 110
           P SF    G+ A ITG G G+GK  +  L+  G   V+ SR ++ L+A A +I   TG  
Sbjct: 40  PKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRS 99

Query: 111 VHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAA--GNFISPTERLSPNAWKTITDIV 168
           V  IQ D    D+ ++   +L  +     I++NN     N +      +P+  +++    
Sbjct: 100 VKIIQADFTKDDIYEHIKEKLAGL--EIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCN 157

Query: 169 LNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEW 228
           +     +T  I K +   QKG   L+I++  A          +++KA V A SK+L  E+
Sbjct: 158 ITSVVKMTQLILKHMESRQKG-LILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEY 216

Query: 229 GKYGMRFNVIQPGPIKT 245
               +   V+ P  + T
Sbjct: 217 KAKEVIIQVLTPYAVST 233


>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 46/199 (23%), Positives = 89/199 (44%), Gaps = 17/199 (8%)

Query: 59  GKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDV 118
           G+V  +TG   G+G+G+   L   GA   I  R +D L+  A++  S  G  V  + CD 
Sbjct: 7   GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVV-CDS 65

Query: 119 RDPDMVQNTVSELIK-VAGHPNIVINNAAGNFISPTERLSPNAWKT-------ITDIVLN 170
                V++   ++ +   G  ++++NNA     +     +   W+T       I ++ L 
Sbjct: 66  SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125

Query: 171 GTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGS---GFVVPSASAKAGVEAMSKSLAAE 227
           G  F ++   + ++ A +G     +  + +  GS    F VP    KA  + ++   A E
Sbjct: 126 GHYFCSVYGARLMVPAGQG-----LIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 180

Query: 228 WGKYGMRFNVIQPGPIKTK 246
             ++G+    + PG ++T+
Sbjct: 181 LRRHGVSCVSLWPGIVQTE 199


>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 46/199 (23%), Positives = 89/199 (44%), Gaps = 17/199 (8%)

Query: 59  GKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDV 118
           G+V  +TG   G+G+G+   L   GA   I  R +D L+  A++  S  G  V  + CD 
Sbjct: 7   GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVV-CDS 65

Query: 119 RDPDMVQNTVSELIK-VAGHPNIVINNAAGNFISPTERLSPNAWKT-------ITDIVLN 170
                V++   ++ +   G  ++++NNA     +     +   W+T       I ++ L 
Sbjct: 66  SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125

Query: 171 GTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGS---GFVVPSASAKAGVEAMSKSLAAE 227
           G  F ++   + ++ A +G     +  + +  GS    F VP    KA  + ++   A E
Sbjct: 126 GHYFCSVYGARLMVPAGQG-----LIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 180

Query: 228 WGKYGMRFNVIQPGPIKTK 246
             ++G+    + PG ++T+
Sbjct: 181 LRRHGVSCVSLWPGIVQTE 199


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 70/259 (27%), Positives = 105/259 (40%), Gaps = 23/259 (8%)

Query: 56  SFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 115
           S +G VA ITGG +GLG      L   GA  V+    +D+  +  E  + + GN      
Sbjct: 7   SVKGLVAVITGGASGLGLATAERLVGQGASAVL----LDLPNSGGEAQAKKLGNNCVFAP 62

Query: 116 CDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKT------ITDIVL 169
            DV     VQ  ++      G  ++ +N A     S T  L      T      + D+ L
Sbjct: 63  ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122

Query: 170 NGT----AFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSA--SAKAGVEAMSKS 223
            GT      V  E+G Q    Q G   + I T       G V  +A  ++K G+  M+  
Sbjct: 123 MGTFNVIRLVAGEMG-QNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLP 181

Query: 224 LAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPC-GRLGTVEELANLAA 282
           +A +    G+R   I PG   T    S  +    F   +  ++P   RLG   E A+L  
Sbjct: 182 IARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNF---LASQVPFPSRLGDPAEYAHLVQ 238

Query: 283 FLCSDYASWINGAVIKFDG 301
            +  +   ++NG VI+ DG
Sbjct: 239 AIIEN--PFLNGEVIRLDG 255


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 59/228 (25%), Positives = 101/228 (44%), Gaps = 18/228 (7%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
           +VA +TG  +G+G  +   L+  GA  VI+SRK   +     ++  + G  V  I C V 
Sbjct: 37  RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGE-GLSVAGIVCHVG 95

Query: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGN-FISPTERLSPNAWKTITDIVLNGTAFVTLE 178
             +  +  V++ ++  G  + ++ +A  N  +  T   S   W  I  + +   A +  +
Sbjct: 96  KAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQ 155

Query: 179 IGKQLIKAQKGAAFL--SITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFN 236
           +    ++ ++GA  L  SI         G    S +A  G   ++++LA E     +R N
Sbjct: 156 L-LPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLG---LTRTLALELAPKDIRVN 211

Query: 237 VIQPGPIKTKGAFSRLDPTGTFEKEMIGR-----IPCGRLG---TVEE 276
            + PG IKT   FS++   G     + GR     I C  LG   TV+E
Sbjct: 212 CVVPGIIKTD--FSKVVRIGFMGMSLSGRTSRNIISCRGLGSQRTVQE 257


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 50/197 (25%), Positives = 85/197 (43%), Gaps = 23/197 (11%)

Query: 59  GKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDV----LKATAEQISSQTGNKVHAI 114
           GKVA +TG   G+G+     L   GA+  +    ++       A  EQ   Q   K   I
Sbjct: 5   GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQ---KTLFI 61

Query: 115 QCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDI----VLN 170
           QCDV D   +++T  +++   G  +I++NNA  N        +   W+    I    V++
Sbjct: 62  QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVSVIS 113

Query: 171 GTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKS--LAAEW 228
           GT      + KQ     +G   ++++++             ++K G+   ++S  LAA  
Sbjct: 114 GTYLGLDYMSKQ--NGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANL 171

Query: 229 GKYGMRFNVIQPGPIKT 245
              G+R N I PG + T
Sbjct: 172 MNSGVRLNAICPGFVNT 188


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 52/198 (26%), Positives = 79/198 (39%), Gaps = 18/198 (9%)

Query: 54  PNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMD---------VLKATAEQIS 104
           P  F G+V  +TG G GLG+      +  GA  V+     D               E+I 
Sbjct: 4   PLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEI- 62

Query: 105 SQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTI 164
            + G K  A    V + + V  T    +   G  ++V+NNA         R+S   W  I
Sbjct: 63  RRRGGKAVANYDSVEEGEKVVKTA---LDAFGRIDVVVNNAGILRDRSFARISDEDWDII 119

Query: 165 TDIVLNGTAFVTLEIGKQLIKAQKGAAFL--SITTIYAETGSGFVVPSASAKAGVEAMSK 222
             + L G+  VT    + + K + G   +  S + IY   G       ++AK G+  ++ 
Sbjct: 120 HRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQ---ANYSAAKLGLLGLAN 176

Query: 223 SLAAEWGKYGMRFNVIQP 240
           SLA E  K  +  N I P
Sbjct: 177 SLAIEGRKSNIHCNTIAP 194


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 54/235 (22%), Positives = 106/235 (45%), Gaps = 24/235 (10%)

Query: 31  ILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIAS 90
           I+Y   E+L  KFF P ++      S  G++  ITG G G+G+  T   +   +  V+  
Sbjct: 14  IIYSYLESLV-KFFIPQRR-----KSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVL-- 65

Query: 91  RKMDVLKATAEQISSQT---GNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAG 147
              D+ K   E+ +++    G   HA   D  + + +  +++++ K  G   IV+NNA  
Sbjct: 66  --WDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNA-- 121

Query: 148 NFISPTERLSPNAWKTITDIVLN--GTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSG 205
             + P + LS    +      +N  G  ++T  +   +++   G   +++ ++    G  
Sbjct: 122 GTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHG-HIVTVASVCGHEGIP 180

Query: 206 FVVPSASAKAGVEAMSKSLAAE---WGKYGMRFNVIQPGPIK---TKGAFSRLDP 254
           +++P  S+K       + L +E    GK G++ + + P  +    TK   +RL P
Sbjct: 181 YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWP 235


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 6/124 (4%)

Query: 22  RRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSS 81
           ++ F +  K L+   EA+    F+ L K   P  +  G++  ITG G+GLG+ +    + 
Sbjct: 9   KKLFIFLGKSLFSLLEAM---IFALLPK---PRKNVAGEIVLITGAGSGLGRLLALQFAR 62

Query: 82  LGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIV 141
           LG+  V+     +  + T +        +VHA  CD    + V     ++ K  G  +I+
Sbjct: 63  LGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSIL 122

Query: 142 INNA 145
           INNA
Sbjct: 123 INNA 126


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 53/222 (23%), Positives = 90/222 (40%), Gaps = 17/222 (7%)

Query: 28  GTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCV 87
           G   +YQ    L SK            ++ Q KV  IT   +GLGK    +  + GA+ V
Sbjct: 18  GLLFIYQEVSRLWSK------------SAVQNKVVVITDAISGLGKECARVFHTGGARLV 65

Query: 88  IASRKMDVLKATAEQ-ISSQTGNKVHA---IQCDVRDPDMVQNTVSELIKVAGHPNIVIN 143
           +  +  + L+   +  IS    +K      +  D+ D   V +   E++   G  +I+IN
Sbjct: 66  LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDILIN 125

Query: 144 NAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETG 203
           NA+     P  ++S    K I D    G   +T  +   +I  + G   L +  I  + G
Sbjct: 126 NASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVL-VNNIQGKFG 184

Query: 204 SGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKT 245
             F    A++K         L AE  +Y +  + + P  I++
Sbjct: 185 IPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 42/180 (23%), Positives = 81/180 (45%), Gaps = 3/180 (1%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
           KVA +T    G+G  +   L+   A  V++SRK   +      +  + G  V    C V 
Sbjct: 33  KVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGE-GLSVTGTVCHVG 91

Query: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGN-FISPTERLSPNAWKTITDIVLNGTAFVTLE 178
             +  +  V+  +K+ G  +I+++NAA N F      ++   W    DI +   A +T  
Sbjct: 92  KAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKA 151

Query: 179 IGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238
           +  ++ K + G + + +++I A + S    P   +K  +  ++ +LA E     +R N +
Sbjct: 152 VVPEMEK-RGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNCL 210


>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 46/190 (24%), Positives = 83/190 (43%), Gaps = 14/190 (7%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLG----AQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 115
           K   +TG  +G G  +   L S G    A C++  +  D +K    ++ S   +++  +Q
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVK----ELDSLNSDRLRTVQ 111

Query: 116 CDVRDPDMVQNTVSELIKVAGHPNI----VINNAAGNFISPTERLSPNAWKTITDIVLNG 171
            +V   + V+  V  +      P      ++NNA  +     E  S   +K + ++ L G
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWG 171

Query: 172 TAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKY 231
           T  +T      LI+  KG   ++I+++     +    P    K GVEA S  L  E    
Sbjct: 172 TVRMTKSF-LPLIRRAKGRV-VNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229

Query: 232 GMRFNVIQPG 241
           G++ +V++PG
Sbjct: 230 GVKVSVVEPG 239


>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 46/190 (24%), Positives = 83/190 (43%), Gaps = 14/190 (7%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLG----AQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 115
           K   +TG  +G G  +   L S G    A C++  +  D +K    ++ S   +++  +Q
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVK----ELDSLNSDRLRTVQ 111

Query: 116 CDVRDPDMVQNTVSELIKVAGHPNI----VINNAAGNFISPTERLSPNAWKTITDIVLNG 171
            +V   + V+  V  +      P      ++NNA  +     E  S   +K + ++ L G
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWG 171

Query: 172 TAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKY 231
           T  +T      LI+  KG   ++I+++     +    P    K GVEA S  L  E    
Sbjct: 172 TVRMTKSF-LPLIRRAKGRV-VNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229

Query: 232 GMRFNVIQPG 241
           G++ +V++PG
Sbjct: 230 GVKVSVVEPG 239


>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 46/190 (24%), Positives = 83/190 (43%), Gaps = 14/190 (7%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLG----AQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 115
           K   +TG  +G G  +   L S G    A C++  +  D +K    ++ S   +++  +Q
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVK----ELDSLNSDRLRTVQ 111

Query: 116 CDVRDPDMVQNTVSELIKVAGHPNI----VINNAAGNFISPTERLSPNAWKTITDIVLNG 171
            +V   + V+  V  +      P      ++NNA  +     E  S   +K + ++ L G
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWG 171

Query: 172 TAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKY 231
           T  +T      LI+  KG   ++I+++     +    P    K GVEA S  L  E    
Sbjct: 172 TVRMTKSF-LPLIRRAKGRV-VNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229

Query: 232 GMRFNVIQPG 241
           G++ +V++PG
Sbjct: 230 GVKVSVVEPG 239


>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
          Length = 387

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 50/211 (23%), Positives = 90/211 (42%), Gaps = 8/211 (3%)

Query: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
           K   +TGG  GLG  +   L  LG    + +  ++     AE++      ++  +Q D+ 
Sbjct: 83  KAVLVTGGDCGLGHALCKYLDELGF--TVFAGVLNENGPGAEELRRTCSPRLSVLQMDIT 140

Query: 120 DPDMVQNTVSELIKVAGHPNI--VINNAAG-NFISPTERLSPNAWKTITDIVLNGTAFVT 176
            P  +++  S++  +     +  VINNA    F +  E L    +K    +   GT  VT
Sbjct: 141 KPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVT 200

Query: 177 LEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFN 236
                 L++  KG   ++++++        +    S+KA V   S  +  E  K+G++  
Sbjct: 201 KTF-LPLLRKSKGR-LVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVA 258

Query: 237 VIQPGPIKTKGAFSRLDPTGTFEKEMIGRIP 267
            IQPG   T  A    D     EK+++  +P
Sbjct: 259 SIQPGGFLTNIA-GTSDKWEKLEKDILDHLP 288


>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
           [Homo sapiens]
          Length = 252

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 64/261 (24%), Positives = 96/261 (36%), Gaps = 36/261 (13%)

Query: 56  SFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 115
           S +G VA ITGG +GLG      L   GA  V+    +D+  +  E  + + GN      
Sbjct: 7   SVKGLVAVITGGASGLGLATAERLVGQGASAVL----LDLPNSGGEAQAKKLGNNCVFAP 62

Query: 116 CDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFV 175
            DV     VQ  ++      G  ++ +N A     S T  L      T+ D         
Sbjct: 63  ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDF-------- 114

Query: 176 TLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRF 235
                ++++       F  I  +  E G     P    + GV   + S+AA  G+ G   
Sbjct: 115 -----QRVLDVNLMGTFNVIRLVAGEMGQN--EPDQGGQRGVIINTASVAAFEGQVGQAA 167

Query: 236 NVIQPGPI--KTKGAFSRLDPTGTFEKEMIGRIP---C----------GRLGTVEELANL 280
                G I   T      L P G F   ++  +P   C           RLG   E A+L
Sbjct: 168 YSASKGGIVGMTLPIARDLAPIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHL 227

Query: 281 AAFLCSDYASWINGAVIKFDG 301
              +  +   ++NG VI+ DG
Sbjct: 228 VQAIIEN--PFLNGEVIRLDG 246


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,175,337
Number of Sequences: 37866
Number of extensions: 509534
Number of successful extensions: 1236
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 1142
Number of HSP's gapped (non-prelim): 68
length of query: 335
length of database: 18,247,518
effective HSP length: 103
effective length of query: 232
effective length of database: 14,347,320
effective search space: 3328578240
effective search space used: 3328578240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.