Search of human proteins with 4503233

Search of human proteins with 4503233

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide
7 [Homo sapiens]
         (503 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...  1010   0.0  
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   902   0.0  
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   843   0.0  
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   750   0.0  
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   746   0.0  
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   631   0.0  
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   310   3e-84
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   310   3e-84
gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II [...   246   3e-65
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        171   1e-42
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   158   1e-38
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   157   2e-38
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   156   4e-38
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   155   8e-38
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   154   1e-37
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   154   1e-37
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   153   3e-37
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   153   3e-37
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   150   3e-36
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   147   2e-35
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   146   5e-35
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   145   1e-34
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  140   2e-33
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   140   3e-33
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   130   3e-30
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   125   9e-29
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   125   1e-28
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   121   2e-27
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...   121   2e-27
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  119   5e-27

>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score = 1010 bits (2611), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60
           MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF
Sbjct: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60

Query: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120
           DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI
Sbjct: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180
           AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180

Query: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240
           MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV
Sbjct: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240

Query: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
           FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI
Sbjct: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300

Query: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360
           IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360

Query: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420
           NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS
Sbjct: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480
           KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480

Query: 481 GLLLTEKPIVLKAESRDETVSGA 503
           GLLLTEKPIVLKAESRDETVSGA
Sbjct: 481 GLLLTEKPIVLKAESRDETVSGA 503


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  902 bits (2332), Expect = 0.0
 Identities = 445/503 (88%), Positives = 475/503 (94%)

Query: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60
           M LIP+LA+ETWLLLAVSL+LLYLYGT +HGLFKKLGIPGPTPLPFLGN LS+ KG+  F
Sbjct: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60

Query: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120
           DMEC+KKY KVWG YD QQP+LAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK+AISI
Sbjct: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180
           AEDEEWKR+RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLK VFGAYS
Sbjct: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180

Query: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240
           MDVITSTSFGV+IDSLNNPQDPFVENTKKLLRF+ LDPF LSI VFPFL PILE LNI V
Sbjct: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240

Query: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
           FPR+V +FL KSVK++KE RL++TQKHRVDFLQLMIDSQNSK++E+HKALSDLEL+AQSI
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360
           IFIFAGYETTSSVLSFI+YELATHPDVQQK+Q+EID VLPNKAPPTYDTVLQ+EYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360

Query: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420
           NETLRLFP+AMRLERVCKKDVEINGMFIPKGVVVMIPSY LH DPKYWTEPEKFLPERFS
Sbjct: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480
           KKNKDNIDPYIYTPFGSGPRNCIGMRFAL+NMKLAL+RVLQNFSFKPCKETQIPLKL  G
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 481 GLLLTEKPIVLKAESRDETVSGA 503
           GLL  EKP+VLK ESRD TVSGA
Sbjct: 481 GLLQPEKPVVLKVESRDGTVSGA 503


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  843 bits (2179), Expect = 0.0
 Identities = 411/502 (81%), Positives = 458/502 (91%), Gaps = 1/502 (0%)

Query: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60
           MDLIPNLAVETWLLLAVSL+LLYLYGTRTHGLFK+LGIPGPTPLP LGN LS+R+G W F
Sbjct: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60

Query: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120
           D ECYKKY K+WG Y+ Q P+LAITDPD+I+TVLVKECYSVFTNRR  GPVGFMK+AIS+
Sbjct: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180
           AEDEEWKRIRSLLSPTFTSGKLKEM PIIAQYGDVLVRNLRREAE GKPVTLK +FGAYS
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180

Query: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240
           MDVIT TSFGV+IDSLNNPQDPFVE+TKK L+F  LDP  LSI +FPFLTP+ EALN+++
Sbjct: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240

Query: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
           FP+  I+FL+KSV ++K+ RL + QKHR+DFLQLMIDSQNSK++E+HKALSDLEL AQSI
Sbjct: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300

Query: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360
           IFIFAGYETTSSVLSF +YELATHPDVQQK+QKEID VLPNKAPPTYD V+Q+EYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360

Query: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420
           NETLRLFPVA+RLER CKKDVEING+FIPKG +V+IP+Y LHHDPKYWTEPE+F PERFS
Sbjct: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480
           KK KD+IDPYIYTPFG+GPRNCIGMRFAL+NMKLAL+RVLQNFSFKPCKETQIPLKL   
Sbjct: 421 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ 479

Query: 481 GLLLTEKPIVLKAESRDETVSG 502
           GLL  EKPIVLK +SRD T+SG
Sbjct: 480 GLLQPEKPIVLKVDSRDGTLSG 501


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  750 bits (1937), Expect = 0.0
 Identities = 359/502 (71%), Positives = 424/502 (84%)

Query: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60
           MDLIPN A+ETW+L+A SL+LLY+YGT +H LFKKLGIPGPTPLPFLG  L + +G W F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120
           D EC +KY ++WG+Y+ QQPML I DPDMIKTVLVKECYSVFTN+ P GP+GF+K+A+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180
           AEDEEWKRIR+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE  K + LK  FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240
           MDVIT T FGV++DSLNNPQDPF++N KKLL+ + LDPF+L I +FPFLTP+ EALNI +
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
           FP+ V  FL  S++++KE RLK+ QKHRVDF Q MIDSQNSK++++HKALSDLEL+AQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360
           I IFA Y+TTS+ L FI+YELATHPDVQQK+Q+EID VLPNKAP TYD ++Q+EYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420
           NETLRLFPV  R+ RVCKKD+EING+FIPKG+ VM+P Y LHHDPKYWTEPEKF PERFS
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480
           KKNKD+ID Y Y PFG+GPRNCIGMRFAL N+KLA++R LQNFSFKPCKETQIPLKL   
Sbjct: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480

Query: 481 GLLLTEKPIVLKAESRDETVSG 502
            +L  EKPIVLK   RD   SG
Sbjct: 481 PILQPEKPIVLKVHLRDGITSG 502


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  746 bits (1925), Expect = 0.0
 Identities = 359/503 (71%), Positives = 424/503 (84%), Gaps = 1/503 (0%)

Query: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60
           MDLIPN A+ETW+L+A SL+LLY+YGT +H LFKKLGIPGPTPLPFLG  L + +G W F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120
           D EC +KY ++WG+Y+ QQPML I DPDMIKTVLVKECYSVFTN+ P GP+GF+K+A+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180
           AEDEEWKRIR+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE  K + LK  FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240
           MDVIT T FGV++DSLNNPQDPF++N KKLL+ + LDPF+L I +FPFLTP+ EALNI +
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
           FP+ V  FL  S++++KE RLK+ QKHRVDF Q MIDSQNSK++++HKALSDLEL+AQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360
           I IFA Y+TTS+ L FI+YELATHPDVQQK+Q+EID VLPNKAP TYD ++Q+EYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPE-RF 419
           NETLRLFPV  R+ RVCKKD+EING+FIPKG+ VM+P Y LHHDPKYWTEPEKF PE RF
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 420

Query: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRF 479
           SKKNKD+ID Y Y PFG+GPRNCIGMRFAL N+KLA++R LQNFSFKPCKETQIPLKL  
Sbjct: 421 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 480

Query: 480 GGLLLTEKPIVLKAESRDETVSG 502
             +L  EKPIVLK   RD   SG
Sbjct: 481 LPILQPEKPIVLKVHLRDGITSG 503


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  631 bits (1628), Expect = 0.0
 Identities = 298/418 (71%), Positives = 357/418 (85%)

Query: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60
           MDLIPN A+ETW+L+A SL+LLY+YGT +H LFKKLGIPGPTPLPFLG  L + +G W F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120
           D EC +KY ++WG+Y+ QQPML I DPDMIKTVLVKECYSVFTN+ P GP+GF+K+A+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180
           AEDEEWKRIR+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE  K + LK  FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240
           MDVIT T FGV++DSLNNPQDPF++N KKLL+ + LDPF+L I +FPFLTP+ EALNI +
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
           FP+ V  FL  S++++KE RLK+ QKHRVDF Q MIDSQNSK++++HKALSDLEL+AQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360
           I IFA Y+TTS+ L FI+YELATHPDVQQK+Q+EID VLPNKAP TYD ++Q+EYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPER 418
           NETLRLFPV  R+ RVCKKD+EING+FIPKG+ VM+P Y LHHDPKYWTEPEKF PER
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  310 bits (793), Expect = 3e-84
 Identities = 179/515 (34%), Positives = 284/515 (55%), Gaps = 34/515 (6%)

Query: 15  LAVSLI-LLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG 73
           L+V+L+ LL  Y T      +KLG+  P P PF+GN   FR+G+W   ME  K Y  + G
Sbjct: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCG 80

Query: 74  IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKNAISIAEDEEWKRIRSL 132
            Y  ++  + I++PDMIK VLV E +S FTNR   G     + +++    D+ W+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGA 139

Query: 133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
           L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S +FG  
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTP 199

Query: 193 IDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252
           +DS   P+DPFV++ K+   F    P ++ +  FP +   L  +       ++  F  K 
Sbjct: 200 VDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKL 259

Query: 253 VKQIKEGRLKET-QKHRVDFLQLMIDSQNS-----------------------------K 282
           ++ +   R ++  ++ R DFLQ+++D+++S                             +
Sbjct: 260 IRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQ 319

Query: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342
            S   + L+  E++ Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+K+ +E+D      
Sbjct: 320 PSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKH 379

Query: 343 APPTYDTVLQ-LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
             P + ++ + L YLDMV+ ETLR++P A R  R   +D E+ G  IP G V+ +    L
Sbjct: 380 MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGAL 439

Query: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
           HHDP++W  PE F PERF+ + +    P+ Y PFG+GPR+C+G+R  L+ +KL L+ VL 
Sbjct: 440 HHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLH 499

Query: 462 NFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496
            F F+ C ETQ+PL+L     L  +  + +K  SR
Sbjct: 500 KFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  310 bits (793), Expect = 3e-84
 Identities = 179/515 (34%), Positives = 284/515 (55%), Gaps = 34/515 (6%)

Query: 15  LAVSLI-LLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG 73
           L+V+L+ LL  Y T      +KLG+  P P PF+GN   FR+G+W   ME  K Y  + G
Sbjct: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCG 80

Query: 74  IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKNAISIAEDEEWKRIRSL 132
            Y  ++  + I++PDMIK VLV E +S FTNR   G     + +++    D+ W+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGA 139

Query: 133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
           L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S +FG  
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTP 199

Query: 193 IDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252
           +DS   P+DPFV++ K+   F    P ++ +  FP +   L  +       ++  F  K 
Sbjct: 200 VDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKL 259

Query: 253 VKQIKEGRLKET-QKHRVDFLQLMIDSQNS-----------------------------K 282
           ++ +   R ++  ++ R DFLQ+++D+++S                             +
Sbjct: 260 IRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQ 319

Query: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342
            S   + L+  E++ Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+K+ +E+D      
Sbjct: 320 PSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKH 379

Query: 343 APPTYDTVLQ-LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
             P + ++ + L YLDMV+ ETLR++P A R  R   +D E+ G  IP G V+ +    L
Sbjct: 380 MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGAL 439

Query: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
           HHDP++W  PE F PERF+ + +    P+ Y PFG+GPR+C+G+R  L+ +KL L+ VL 
Sbjct: 440 HHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLH 499

Query: 462 NFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496
            F F+ C ETQ+PL+L     L  +  + +K  SR
Sbjct: 500 KFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534


>gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
           [Homo sapiens]
          Length = 460

 Score =  246 bits (628), Expect = 3e-65
 Identities = 148/438 (33%), Positives = 237/438 (54%), Gaps = 34/438 (7%)

Query: 15  LAVSLI-LLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG 73
           L+V+L+ LL  Y T      +KLG+  P P PF+GN   FR+G+W   ME  K Y  + G
Sbjct: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCG 80

Query: 74  IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKNAISIAEDEEWKRIRSL 132
            Y  ++  + I++PDMIK VLV E +S FTNR   G     + +++    D+ W+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGA 139

Query: 133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192
           L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S +FG  
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTP 199

Query: 193 IDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252
           +DS   P+DPFV++ K+   F    P ++ +  FP +   L  +       ++  F  K 
Sbjct: 200 VDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKL 259

Query: 253 VKQIKEGRLKE-TQKHRVDFLQLMIDSQNS-----------------------------K 282
           ++ +   R ++  ++ R DFLQ+++D+++S                             +
Sbjct: 260 IRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQ 319

Query: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342
            S   + L+  E++ Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+K+ +E+D      
Sbjct: 320 PSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKH 379

Query: 343 APPTYDTVLQ-LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
             P + ++ + L YLDMV+ ETLR++P A R  R   +D E+ G  IP G V+ +    L
Sbjct: 380 MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGAL 439

Query: 402 HHDPKYWTEPEKFLPERF 419
           HHDP++W  PE F PER+
Sbjct: 440 HHDPEHWPSPETFNPERY 457


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  171 bits (433), Expect = 1e-42
 Identities = 126/476 (26%), Positives = 231/476 (48%), Gaps = 37/476 (7%)

Query: 13  LLLAVSLIL---LYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYR 69
           +LL +SL+L   + LY  R   +      P P    F G+     K +  + ++ ++ Y 
Sbjct: 18  ILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGH-----KEF--YPVKEFEVYH 70

Query: 70  KVWGIYDCQQPM--------LAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIA 121
           K+   Y C  P+         ++ DPD  K +L ++      + +      ++   +   
Sbjct: 71  KLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTL 128

Query: 122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSM 181
           +  +WK+ R ++ P F    LK  + ++++   +++            + L       ++
Sbjct: 129 DGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTL 188

Query: 182 DVITSTSFG----VSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALN 237
           D I   +F     + +DS  +     V N  K+      +    +  VF F +   +   
Sbjct: 189 DSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSS---QGQI 245

Query: 238 ITVFPRKVISFLTKSVKQIKEG---RLKE--TQKHRVDFLQLMIDSQNSKDSETHKALSD 292
            + F +++  F  K ++  KE    +LK+  TQK R DFL +++ ++    SE  K  S+
Sbjct: 246 FSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAK----SENTKDFSE 301

Query: 293 LELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQ 352
            +L A+   F+FAG++TTSS +S+I+Y LA +P+ QQ+ + EI  +L + +  T++ + Q
Sbjct: 302 ADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQ 361

Query: 353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEP 411
           + Y  M + E LRL+   + + R+  K +   +G  +P G+ V I  + LHH+P +W +P
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421

Query: 412 EKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467
           + F P RFS++N + I PY + PF +G RNCIG  FA++  K+A+   L  F   P
Sbjct: 422 QVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP 477


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  158 bits (400), Expect = 1e-38
 Identities = 125/477 (26%), Positives = 232/477 (48%), Gaps = 39/477 (8%)

Query: 14  LLAVSLILLYLYGTRTHGLFKKLGIPGPT---PLPFLGNALSFR---KGYWTFDMECYKK 67
           L   SL+L  L    ++    +   P PT     P +G+AL  +   + ++   +E  ++
Sbjct: 24  LAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEE 83

Query: 68  YRKV--WGIYDCQQPMLAITDPDMIKTVLVK----ECYSVFTNRRPFGPVGFMKNAISIA 121
           YR +    ++    PM+A+ + + ++ +L      +  S++    P+  +G + +     
Sbjct: 84  YRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTST---- 139

Query: 122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSM 181
              +W+  R +L+PTF    L++ + I+ +  ++LV+ L +     +           ++
Sbjct: 140 -GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQ-EAFNCFFYITLCAL 197

Query: 182 DVITSTSFGVSIDSLNNPQDPFVENTKKL---------LRFNPLDPFVLSIKVFPFLTPI 232
           D+I  T+ G +I + +N    +V    ++         + +  LD + L  K        
Sbjct: 198 DIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKS 257

Query: 233 LEALNITVFPRKVISFLTKSVKQIKE----GRLKETQKH-RVDFLQLMIDSQNSKDSETH 287
           L+ L+   F   VI+     +   ++    GR     K+ R  FL L++   + + +   
Sbjct: 258 LQILH--TFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNR-- 313

Query: 288 KALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPT 346
             LS  ++  +   F+F G++TT++ +++ +Y L ++P+VQ+KV  E+D V   +  P T
Sbjct: 314 --LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPAT 371

Query: 347 YDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPK 406
            + + +L YL+ V+ ETLRLFP      R   +D E+ G  + KG   +I  Y LH DP+
Sbjct: 372 VEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPR 431

Query: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
           Y+  PE+F PERF  +N     PY Y PF +GPRNCIG +FA++  K  L  +L++F
Sbjct: 432 YFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  157 bits (397), Expect = 2e-38
 Identities = 115/434 (26%), Positives = 200/434 (46%), Gaps = 35/434 (8%)

Query: 80  PMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----NAISIAEDEEWKRIRSLLSP 135
           P + +  PD I+++      ++      F  + F+K      I ++  ++W R R +L+P
Sbjct: 97  PFIVLCHPDTIRSI-TNASAAIAPKDNLF--IRFLKPWLGEGILLSGGDKWSRHRRMLTP 153

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VTLKHVFGAYSMDVITSTSFGVSID 194
            F    LK  + I  +  ++++   +  A  G   + +       ++D +    F     
Sbjct: 154 AFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSH 213

Query: 195 SLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTP-----------ILEALNITVFPR 243
               P +      +           +L    F +              ++      V   
Sbjct: 214 CQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRE 273

Query: 244 KVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFI 303
           +  +  T+ +    + + K      +D L L      SKD E  KALSD ++ A++  F+
Sbjct: 274 RRRTLPTQGIDDFFKDKAKSKTLDFIDVLLL------SKD-EDGKALSDEDIRAEADTFM 326

Query: 304 FAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLDMVVN 361
           F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + QL +L M V 
Sbjct: 327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVK 386

Query: 362 ETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420
           E+LRL P A  + R C +D+ + +G  IPKG+  +I    +HH+P  W +PE + P RF 
Sbjct: 387 ESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFD 446

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRF- 479
            +N     P  + PF +GPRNCIG  FA+  MK+ L  +L +F F P   T+   KL   
Sbjct: 447 PENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP-DHTEPRRKLELI 505

Query: 480 ----GGLLLTEKPI 489
               GGL L  +P+
Sbjct: 506 MRAEGGLWLRVEPL 519


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  156 bits (395), Expect = 4e-38
 Identities = 117/410 (28%), Positives = 201/410 (49%), Gaps = 35/410 (8%)

Query: 80  PMLAITDPDMIKTVLVKECYSVFTNR-----RPFGPVGFMKNAISIAEDEEWKRIRSLLS 134
           P++ +  PD++++V+        T++     +   P  ++ + + ++  ++W+  R LL+
Sbjct: 97  PIINLCHPDIVRSVI--NTSDAITDKDIVFYKTLKP--WLGDGLLLSVGDKWRHHRRLLT 152

Query: 135 PTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV-SI 193
           P F    LK  + I ++  +++    +R A  G   T   VF   S+  + S    + S 
Sbjct: 153 PAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS--TCLDVFEHISLMTLDSLQKCIFSF 210

Query: 194 DSLNNPQDPFVENTKKLLRFNPL-----DPFVLSIKVFPFLTPILEALNITVFPRKVISF 248
           DS  N Q+   E    ++  + L     + F        FLTP     +      +++  
Sbjct: 211 DS--NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRAC---RLVHD 265

Query: 249 LTKSVKQIKEGRLKETQKHRVDFLQL--------MIDSQNSKDSETHKALSDLELMAQSI 300
            T +V  I+E R   T +   DFLQ          ID     + +  K LSD ++ A++ 
Sbjct: 266 FTDAV--IQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEAD 323

Query: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLDM 358
            F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + QL +L M
Sbjct: 324 TFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTM 383

Query: 359 VVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPE 417
            + E+LRL P      R C +DV + +   IPKG V  I  + +HH+P  W +PE + P 
Sbjct: 384 CLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPF 443

Query: 418 RFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467
           RF  +N     P  + PF +GPRNCIG +FA+  MK+ L   L  F   P
Sbjct: 444 RFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP 493


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  155 bits (392), Expect = 8e-38
 Identities = 116/400 (29%), Positives = 199/400 (49%), Gaps = 34/400 (8%)

Query: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VT 171
           ++ + + ++  E+W R R +L+P F    LK  + I  +  +++    +  A  G   + 
Sbjct: 131 WLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLD 190

Query: 172 LKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPL-----DPFVLSIKVF 226
           +       ++D +    F  S DS  + Q+   E    +L  + L        +L I   
Sbjct: 191 MFEHISLMTLDSLQKCVF--SFDS--HCQEKPSEYIAAILELSALVTKRHQQILLYIDFL 246

Query: 227 PFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQN------ 280
            +LTP  +         +++   T +V  I+E R     +   DFLQ    S+       
Sbjct: 247 YYLTPDGQRFRRAC---RLVHDFTDAV--IQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301

Query: 281 ---SKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDT 337
              SKD E  K LSD ++ A++  F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  
Sbjct: 302 LLLSKD-EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 360

Query: 338 VLPNKAPPT--YDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVV 394
           +L ++ P    +D + QL +L M + E+LRL P    + R C +D+ + +G  IPKG++ 
Sbjct: 361 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC 420

Query: 395 MIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKL 454
           +I  +  HH+P  W +PE + P RF  KN     P  + PF +GPRNCIG  FA+  MK+
Sbjct: 421 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480

Query: 455 ALVRVLQNFSF-----KPCKETQIPLKLRFGGLLLTEKPI 489
            L   L  F       +P ++ ++ L+   GGL L  +P+
Sbjct: 481 VLGLTLLRFRVLPDHTEPRRKPELVLRAE-GGLWLRVEPL 519


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  154 bits (390), Expect = 1e-37
 Identities = 116/435 (26%), Positives = 209/435 (48%), Gaps = 37/435 (8%)

Query: 80  PMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----NAISIAEDEEWKRIRSLLSP 135
           P+L +  PD+I+ +      +V      F   GF+K    + + ++  ++W R R +L+P
Sbjct: 97  PLLILCHPDIIRPITSASA-AVAPKDMIF--YGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VTLKHVFGAYSMDVITSTSFGVSID 194
            F    LK  + I  +  +++    +R A  G   + +       ++D +    F    +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213

Query: 195 SLNNPQDPFVENTKKLLRF--NPLDPFVLSIKVFPFLTP----------ILEALNITVFP 242
               P + ++    +L  F        +L      +LTP          ++      V  
Sbjct: 214 CQEKPSE-YIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQ 272

Query: 243 RKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIF 302
            +  +  T+ +    + + K      +D L L      SKD E  K LSD ++ A++  F
Sbjct: 273 ERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLL------SKD-EDGKELSDEDIRAEADTF 325

Query: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLDMVV 360
           +F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + QL +L M +
Sbjct: 326 MFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCI 385

Query: 361 NETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF 419
            E+LRL P    + R C +D  + +G  IPKG+V +I    +H++P  W +PE + P RF
Sbjct: 386 KESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRF 445

Query: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF-----KPCKETQIP 474
            ++N     P  + PF +GPRNCIG  FA+  MK+ L   L +F       +P ++ ++ 
Sbjct: 446 DQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELI 505

Query: 475 LKLRFGGLLLTEKPI 489
           L+   GGL L  +P+
Sbjct: 506 LRAE-GGLWLRVEPL 519


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  154 bits (390), Expect = 1e-37
 Identities = 116/435 (26%), Positives = 209/435 (48%), Gaps = 37/435 (8%)

Query: 80  PMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----NAISIAEDEEWKRIRSLLSP 135
           P+L +  PD+I+ +      +V      F   GF+K    + + ++  ++W R R +L+P
Sbjct: 97  PLLILCHPDIIRPITSASA-AVAPKDMIF--YGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VTLKHVFGAYSMDVITSTSFGVSID 194
            F    LK  + I  +  +++    +R A  G   + +       ++D +    F    +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213

Query: 195 SLNNPQDPFVENTKKLLRF--NPLDPFVLSIKVFPFLTP----------ILEALNITVFP 242
               P + ++    +L  F        +L      +LTP          ++      V  
Sbjct: 214 CQEKPSE-YIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQ 272

Query: 243 RKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIF 302
            +  +  T+ +    + + K      +D L L      SKD E  K LSD ++ A++  F
Sbjct: 273 ERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLL------SKD-EDGKELSDEDIRAEADTF 325

Query: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLDMVV 360
           +F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + QL +L M +
Sbjct: 326 MFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCI 385

Query: 361 NETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF 419
            E+LRL P    + R C +D  + +G  IPKG+V +I    +H++P  W +PE + P RF
Sbjct: 386 KESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRF 445

Query: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF-----KPCKETQIP 474
            ++N     P  + PF +GPRNCIG  FA+  MK+ L   L +F       +P ++ ++ 
Sbjct: 446 DQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELI 505

Query: 475 LKLRFGGLLLTEKPI 489
           L+   GGL L  +P+
Sbjct: 506 LRAE-GGLWLRVEPL 519


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  153 bits (387), Expect = 3e-37
 Identities = 123/471 (26%), Positives = 226/471 (47%), Gaps = 31/471 (6%)

Query: 15  LAVSLI-LLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG 73
           LA+ L+  + LY  R   L      P P    FLG+    +        E  +KY + + 
Sbjct: 22  LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFP 81

Query: 74  IYDCQ-QPMLAITDPDMIKTVLVK-ECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRS 131
            +    Q    I DPD  KT+L + +  S +  +  F P   +   ++  +  +W + R 
Sbjct: 82  FWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQK--FSPP-LLGKGLAALDGPKWFQHRR 138

Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAET-GKPVTLKHVFGAYSMDVITSTSFG 190
           LL+P F    LK  + ++A    +++    +   T    V +     + S+D+I   +F 
Sbjct: 139 LLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFS 198

Query: 191 VSID-SLNNPQDPFVENTKKL----------LRFNPLDPFVLSIKVFPF--LTPILEALN 237
              +   N+  DP+ +   +L          L ++    F LS + + F  L+ +L    
Sbjct: 199 KETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYT 258

Query: 238 ITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMA 297
            T+   +  S L   VKQ    + K       DFL +++ +++    E+  + SD+++ +
Sbjct: 259 DTIIQERKKS-LQAGVKQDNTPKRKYQ-----DFLDIVLSAKD----ESGSSFSDIDVHS 308

Query: 298 QSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLD 357
           +   F+ AG++T ++ +S+I+Y LA +P+ Q++ ++E+  +L + +  T+D + ++ Y  
Sbjct: 309 EVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTT 368

Query: 358 MVVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLP 416
           M + ET RL P    + R   K +   +G  +P G+ V++  + LHH+P  W  P+ F P
Sbjct: 369 MCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDP 428

Query: 417 ERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467
            RFS++N D   PY Y PF +G RNCIG  FA++ +K+ +  +L +F   P
Sbjct: 429 LRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP 479


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  153 bits (387), Expect = 3e-37
 Identities = 120/435 (27%), Positives = 216/435 (49%), Gaps = 34/435 (7%)

Query: 80  PMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----NAISIAEDEEWKRIRSLLSP 135
           P+L +  PD IK +L     ++      F   GF+K    + + +++ ++W R R LL+P
Sbjct: 105 PLLVLVHPDYIKPLLGASA-AIAPKDDLF--YGFLKPWLGDGLLLSKGDKWSRHRRLLTP 161

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS 195
            F    LK  + I  Q  D++    R  AE G  V+L  +F   S+  +T  S    + S
Sbjct: 162 AFHFDILKPYMKIFNQSADIMHAKWRHLAE-GSAVSLD-MFEHISL--MTLDSLQKCVFS 217

Query: 196 LN-NPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPIL----------EALNITV-FPR 243
            N N Q+   +    ++  + L       ++  +L  I           +A ++   F  
Sbjct: 218 YNSNCQEKMSDYISAIIELSALS-VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT 276

Query: 244 KVISFLTKSVKQI-KEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIF 302
           +VI    ++++Q   E  LK  Q   +DF+ +++ +++    E  K LSD ++ A++  F
Sbjct: 277 EVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTF 332

Query: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLDMVV 360
           +F G++TTSS +S++++ LA +P+ Q+K ++EI  V+  +      +D + QL +  M +
Sbjct: 333 MFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCI 392

Query: 361 NETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF 419
            E+LR +P    + R C +D+++ +G  IPKG++ ++  Y  HH+P  W + + + P RF
Sbjct: 393 KESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRF 452

Query: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRF 479
              N     P  Y PF +GPRNCIG  FA+  +++ +   L  F     +  ++  K   
Sbjct: 453 DPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPEL 512

Query: 480 GGLLLTEKPIVLKAE 494
             +L TE  + LK E
Sbjct: 513 --ILRTENGLWLKVE 525


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  150 bits (379), Expect = 3e-36
 Identities = 119/435 (27%), Positives = 215/435 (49%), Gaps = 37/435 (8%)

Query: 80  PMLAITDPDMIKTVLVKECYSVFTNRRPFGPVG-FMKNAISIAEDEEWKRIRSLLSPTFT 138
           P+L++  PD+I++V+         ++  +  +  ++ + + ++  ++W R R +L+P F 
Sbjct: 97  PLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFH 156

Query: 139 SGKLKEMVPIIAQYGDVLVRNLRREAETGKPVT--LKHVFGAYSMDVITSTSFGVSIDSL 196
              LK  + I  +  +++    +  A  G       +H+    ++D +    F  S DS 
Sbjct: 157 FNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHI-SLMTLDSLQKCVF--SFDS- 212

Query: 197 NNPQDPFVENTKKLLRFNPL-----DPFVLSIKVFPFLTPILEALNITVFPRKVISFLTK 251
            + Q+   E    +L  + L        +L I    +LTP  +         +++   T 
Sbjct: 213 -HCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRAC---RLVHDFTD 268

Query: 252 SVKQIKEGRLKETQKHRVDFLQLMIDSQN---------SKDSETHKALSDLELMAQSIIF 302
           +V  I+E R     +   DFLQ    S+          SKD E  K LSD ++ A++  F
Sbjct: 269 AV--IQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD-EDGKKLSDEDIRAEADTF 325

Query: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLDMVV 360
           +F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D +  L +L M +
Sbjct: 326 MFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCM 385

Query: 361 NETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF 419
            E+LRL P    + R   +D+ + +G  IPKG++ +I  +  HH+P  W +PE + P RF
Sbjct: 386 KESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 445

Query: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF-----KPCKETQIP 474
             +N     P  + PF +GPRNCIG  FA+  MK+ L   L  F       +P ++ ++ 
Sbjct: 446 DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELV 505

Query: 475 LKLRFGGLLLTEKPI 489
           L+   GGL L  +P+
Sbjct: 506 LRAE-GGLWLRVEPL 519


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  147 bits (372), Expect = 2e-35
 Identities = 111/428 (25%), Positives = 198/428 (46%), Gaps = 33/428 (7%)

Query: 82  LAITDPDMIKTVLVK------ECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSP 135
           L I +PD  K V  +      + Y  F          ++   + + E  +W + R LL+P
Sbjct: 92  LNIYEPDYAKAVYSRGDPKAPDVYDFFLQ--------WIGRGLLVLEGPKWLQHRKLLTP 143

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS 195
            F    LK  V +  +   +++     +A  GK   +    G  +++ +   +FG     
Sbjct: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203

Query: 196 LNNPQDP---FVENTKKLLRFNPLDPFVLSIKVFPFLTP----ILEALNITVFPRKVISF 248
           L + +D       +   LL    L  F        +LTP     L A  +       +  
Sbjct: 204 LGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIR 263

Query: 249 LTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYE 308
             K+  Q ++ R K   +  +DFL +++ +++  D +    LSD +L A+   F+F G++
Sbjct: 264 ERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVDTFMFEGHD 319

Query: 309 TTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFP 368
           TT+S +S+ +Y +A +P+ Q + ++E+  +L ++    +D + ++ YL M + E+ RL+P
Sbjct: 320 TTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYP 379

Query: 369 VAMRLERVCKKDVE-INGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNI 427
              ++ R   K V  ++G  +P G ++ +  Y LH +   W +PE F   RFS +N    
Sbjct: 380 PVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKR 439

Query: 428 DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK------PCKETQIPLKLRFGG 481
            P+ + PF +GPRNCIG +FA+  MK+     L  F F       P K  Q+ L+ +  G
Sbjct: 440 HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSK-NG 498

Query: 482 LLLTEKPI 489
             L  KP+
Sbjct: 499 FHLHLKPL 506


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  146 bits (368), Expect = 5e-35
 Identities = 110/427 (25%), Positives = 197/427 (46%), Gaps = 32/427 (7%)

Query: 82  LAITDPDMIKTVLVK------ECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSP 135
           L I +PD  K V  +      + Y  F          ++   + + E  +W + R LL+P
Sbjct: 92  LNIYEPDYAKAVYSRGDPKAPDVYDFFLQ--------WIGRGLLVLEGPKWLQHRKLLTP 143

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS 195
            F    LK  V +  +   +++     +A  GK   +    G  +++ +   +FG     
Sbjct: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203

Query: 196 LNNPQDPF--VENTKKLLRFNPLDPFVLSIKVFPFLTP----ILEALNITVFPRKVISFL 249
           L +    +    +   LL    L  F        +LTP     L A  +       +   
Sbjct: 204 LGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRE 263

Query: 250 TKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYET 309
            K+  Q ++ R K   +  +DFL +++ +++  D +    LSD +L A+   F+F G++T
Sbjct: 264 RKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVDTFMFEGHDT 319

Query: 310 TSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPV 369
           T+S +S+ +Y +A +P+ Q + ++E+  +L ++    +D + ++ YL M + E+ RL+P 
Sbjct: 320 TTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPP 379

Query: 370 AMRLERVCKKDVE-INGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNID 428
             ++ R   K V  ++G  +P G ++ +  Y LH +   W +PE F   RFS +N     
Sbjct: 380 VPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRH 439

Query: 429 PYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK------PCKETQIPLKLRFGGL 482
           P+ + PF +GPRNCIG +FA+  MK+     L  F F       P K  Q+ L+ +  G 
Sbjct: 440 PFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSK-NGF 498

Query: 483 LLTEKPI 489
            L  KP+
Sbjct: 499 HLHLKPL 505


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  145 bits (365), Expect = 1e-34
 Identities = 109/402 (27%), Positives = 196/402 (48%), Gaps = 21/402 (5%)

Query: 86  DPDMIKTVLVKECYSVFTNRRPFGP-VGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKE 144
           DPD +K +L +       + R   P +G+    + +   + W + R +L+P F    LK 
Sbjct: 101 DPDYMKVILGRSDPKSHGSYRFLAPWIGY---GLLLLNGQTWFQHRRMLTPAFHYDILKP 157

Query: 145 MVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFG----VSIDSLNNPQ 200
            V ++A    V++           P+ +       ++D I   +F     + +D  +   
Sbjct: 158 YVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSY 217

Query: 201 DPFVENTKKLLRFNPLDPFVLSIKVFPFLTP---ILEALNITVFPRKVISFLTKSVKQIK 257
              + +   L+     + F  +  ++   +       A  +       +  L K+  Q K
Sbjct: 218 IQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQ-K 276

Query: 258 EGRLKETQKHR-VDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSF 316
           EG L++ ++ R +DFL +++ ++     E    LSD +L A+   F+F G++TT+S +S+
Sbjct: 277 EGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTFMFEGHDTTASGISW 332

Query: 317 IIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERV 376
           I+Y LATHP  Q++ ++EI ++L + A  T++ + Q+ Y  M + E LRL+P    + R 
Sbjct: 333 ILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRE 392

Query: 377 CKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435
               V   +G  +PKG++V++  Y LHH+PK W  PE F P RF+  +  +   + + PF
Sbjct: 393 LSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQH--SHAFLPF 450

Query: 436 GSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477
             G RNCIG +FA+  +K+A    L  F   P   T+IP+ +
Sbjct: 451 SGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIPIPI 491


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  140 bits (354), Expect = 2e-33
 Identities = 114/473 (24%), Positives = 216/473 (45%), Gaps = 42/473 (8%)

Query: 13  LLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFD----------- 61
           +LLA  L   +++  R+    +   IPGP    FL   L     +W  D           
Sbjct: 12  VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFL---LGHLPCFWKKDEVGGRVLQDVF 64

Query: 62  MECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTN-----RRPFGPVGFMKN 116
           ++  KKY  V  +    +  + +T P+ +K  L+   Y+  +      +  FG   F + 
Sbjct: 65  LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124

Query: 117 AISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVF 176
            +S    E W + R ++   F+   L  ++    +  + LV  L  +A+   PV+++ + 
Sbjct: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184

Query: 177 GAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEAL 236
              +MD++   +FG+    L   Q P  +  K +L         L+ K  P     L  +
Sbjct: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA-KFLPGKRKQLREV 243

Query: 237 NITVFPRKVISFLTKSVK---QIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDL 293
                 R+ I FL +  +   Q +   LK  ++   D L  ++ ++         A  D 
Sbjct: 244 ------RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEG-------AQDDE 290

Query: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQL 353
            L+   + F  AG+ET+++ L+F + EL+  P++  ++Q E+D V+ +K    ++ + +L
Sbjct: 291 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 350

Query: 354 EYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEK 413
           +YL  V+ E+LRL+P A    R+ +++  I+G+ +P    ++  +YV+     Y+ +P  
Sbjct: 351 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 410

Query: 414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466
           F P+RF          + Y PF  G R+CIG +FA + +K+ + ++LQ   F+
Sbjct: 411 FNPDRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  140 bits (353), Expect = 3e-33
 Identities = 109/417 (26%), Positives = 202/417 (48%), Gaps = 25/417 (5%)

Query: 71  VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGP-VGFMKNAISIAEDEEWKRI 129
           +WG     +  + + DPD +K +L +       + +   P +G+    + +   + W + 
Sbjct: 90  IWG----GKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGY---GLLLLNGQTWFQH 142

Query: 130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSF 189
           R +L+P F +  LK  V ++A    V++           P+ +       ++D I  ++F
Sbjct: 143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202

Query: 190 G----VSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTP---ILEALNITVFP 242
                + +D  +      + +   L+     + F  +  ++   +       A  +    
Sbjct: 203 SHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262

Query: 243 RKVISFLTKSVKQIKEGRLKETQKHR-VDFLQLMIDSQNSKDSETHKALSDLELMAQSII 301
              +  L K+  Q KEG L++ ++ R +DFL +++ ++     E    LSD +L A+   
Sbjct: 263 TDQVIQLRKAQLQ-KEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDT 317

Query: 302 FIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVN 361
           F+F G++TT+S +S+I+Y LATHP  Q++ ++EI  +L + A  T++ + Q+ Y  M + 
Sbjct: 318 FMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIK 377

Query: 362 ETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420
           E LRL+P    + R     V   +G  +PKG++V++  Y LHH+PK W   E F P RF+
Sbjct: 378 EALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFA 437

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477
             +  +   + + PF  G RNCIG +FA+  +K+A    L  F   P   T+IP+ +
Sbjct: 438 PGSAQH--SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIPIPM 491


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  130 bits (327), Expect = 3e-30
 Identities = 115/459 (25%), Positives = 200/459 (43%), Gaps = 34/459 (7%)

Query: 39  PGPTPLPFLGN--ALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVK 96
           PGP  LPFLGN   + F + +    +   KKY  ++ +       + IT   +IK  L+ 
Sbjct: 45  PGPWRLPFLGNFFLVDFEQSHLEVQL-FVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 97  ECYSVFTNRRPFGPVG---FMKNAISIAEDEEWKRIRSLLSPT---FTSGK--LKEMVPI 148
              +     RP  P+    F KN + ++  + WK  R         F  GK  L+E +  
Sbjct: 104 MDQNF--GNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQE 161

Query: 149 IAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTK 208
            AQ+    ++      E G+P            ++I S +FG   +     QD + +   
Sbjct: 162 EAQHLTEAIKE-----ENGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLL 212

Query: 209 KLL---RFNPLDPFVLSIKVFPFLTPILEALNITVFP--RKVISFLTKSV-KQIKEGRLK 262
           KLL    +           VFP++   L   + T+F   +K+  F++  + K  K+    
Sbjct: 213 KLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPA 272

Query: 263 ETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELA 322
           ET+    DF+   +   +        +  +  L+  ++   FAG ETTS+ L + +  +A
Sbjct: 273 ETR----DFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMA 328

Query: 323 THPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFP-VAMRLERVCKKDV 381
            +P++Q+KVQ EID V+     P+      + Y + V++E  R+   + + + R    D 
Sbjct: 329 LYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDT 388

Query: 382 EINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
            + G  +PKG +++     LH DP  W  P+ F P+ F  +N        + PF  G R 
Sbjct: 389 TLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKKREAFMPFSIGKRA 447

Query: 442 CIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480
           C+G + A   + +    ++Q F+F+P    ++ LK R G
Sbjct: 448 CLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMG 486


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  125 bits (314), Expect = 9e-29
 Identities = 124/482 (25%), Positives = 218/482 (45%), Gaps = 62/482 (12%)

Query: 38  IPGPTPLPFLGNALSF------RKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIK 91
           +PGPT  P LG+ L        +K + T  +E +KKY K++ +       + +  P +++
Sbjct: 58  LPGPTSWPLLGSLLQILWKGGLKKQHDTL-VEYHKKYGKIFRMKLGSFESVHLGSPCLLE 116

Query: 92  TVLVKECYSVFTNRRPFGPVGFMKN------AISIAEDEEWKRIRSLLSPTFTSGKLKEM 145
            +   E  S +  R    P    ++       + I E E+W+R+RS         K  E+
Sbjct: 117 ALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPGEV 172

Query: 146 VPIIAQYGDVLVRNLRREAET----GKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQD 201
           + +  +  +VL   + R  E     G    L      +S + I    +            
Sbjct: 173 MKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLY------------ 220

Query: 202 PFVENTKKLLRFNPLDP---FVLSIKVFP------FLTPIL--EALNITVFPRKVISFLT 250
              E    LL+ N  D    F+++IK          +TP+   ++LN  V+    +++ T
Sbjct: 221 ---EKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDT 277

Query: 251 --KSVKQIKEGRL-KETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGY 307
             KSVK   + RL K +Q+   DFL  +         E + A+++L+L         A  
Sbjct: 278 IFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQL---------AAV 328

Query: 308 ETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLF 367
           ETT++ L +I+Y L+ +P VQQK+ KEI +VLP    P  + +  + YL   + E++RL 
Sbjct: 329 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLT 388

Query: 368 PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNI 427
           P      R   K   +    +PKG V+M+ + VL      + +  +F PER+ ++ K+ I
Sbjct: 389 PSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE-KEKI 447

Query: 428 DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEK 487
           +P+ + PFG G R CIG R A + + LAL  +++ +  +       P+++   G L+  +
Sbjct: 448 NPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE--PVEMLHSGTLVPSR 505

Query: 488 PI 489
            +
Sbjct: 506 EL 507


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  125 bits (313), Expect = 1e-28
 Identities = 114/395 (28%), Positives = 181/395 (45%), Gaps = 42/395 (10%)

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVL-------VRNLRREAE--TGKPVT 171
           AE EEW+R+RSLL+P     +        A+Y   L       VR LRR+    TG P  
Sbjct: 129 AEGEEWQRLRSLLAPLLLRPQAA------ARYAGTLNNVVCDLVRRLRRQRGRGTGPPAL 182

Query: 172 LKHVFGAY---SMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPF 228
           ++ V G +    ++ I +   G  +  L     P   +T+  +R       V S+ V   
Sbjct: 183 VRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPP---DTETFIRA------VGSVFVSTL 233

Query: 229 LTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHK 288
           LT  +      + P      L +   Q+     +  ++   +   +    Q  KD E+  
Sbjct: 234 LTMAMPHWLRHLVPGPW-GRLCRDWDQMFAFAQRHVERREAE-AAMRNGGQPEKDLESGA 291

Query: 289 ALSDL----ELMAQSII-----FIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL 339
            L+      EL AQSI+      + AG +T S+ LS+ +YEL+ HP+VQ  +  EI   L
Sbjct: 292 HLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAAL 351

Query: 340 P--NKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIP 397
              + A P+   + QL  L  VV E LRL+PV     RV  KD+ +    IPK  +V + 
Sbjct: 352 SPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLC 411

Query: 398 SYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALV 457
            Y    DP  + EP  F P R+  +      P+   PFG G R+C+G R A + +++AL 
Sbjct: 412 HYATSRDPAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALA 470

Query: 458 RVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLK 492
           ++L +F  +P +    P++ +   +L+ E+ I L+
Sbjct: 471 QILTHFEVQP-EPGAAPVRPKTRTVLVPERSINLQ 504


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  121 bits (303), Expect = 2e-27
 Identities = 120/498 (24%), Positives = 212/498 (42%), Gaps = 54/498 (10%)

Query: 39  PGPTPLPFLGNA--------------LSFRKGYWTFDMECY----------KKYRKVWGI 74
           PGPTP P +GN               LS R      D              + Y  ++  
Sbjct: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120

Query: 75  YDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFM---KNAISIAEDEEWKRIRS 131
           +     ++ ++D   ++  LV++   VF++R     +  +   K  +       W++ R 
Sbjct: 121 FIGHYLVVVLSDFHSVREALVQQA-EVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRK 179

Query: 132 LLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTS 188
               T   F  GKL     II ++  V     +   +   P ++  +  A S ++I S  
Sbjct: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSI--ISNAVS-NIICSLC 236

Query: 189 FGVSIDSLNNPQDPFVENTKKLLRFNP------LDPFVLSIKVFPFL--TPILEALNITV 240
           FG   D  N+         KK+L F        L+  VL + + P+L   P      +  
Sbjct: 237 FGQRFDYTNS-------EFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQ 289

Query: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
             + + SFL K +K  +E   +E  +  +D   L ++ +   +S +     D E +   I
Sbjct: 290 IEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS---FDEEYLFYII 346

Query: 301 IFIF-AGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMV 359
             +F AG +TT++ L + +  ++ +PDVQ+KV +EI+ V+     P+     Q+ Y +  
Sbjct: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEAT 406

Query: 360 VNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPER 418
           + E  RL  V  + +  +  ++  + G  IPKG +++   + +H DP  W +PE F P R
Sbjct: 407 IMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNR 466

Query: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLR 478
           F       I    + PFG G R C+G + A + + L  V ++Q+F+F   ++++ PL   
Sbjct: 467 FLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTG 526

Query: 479 FGGLLLTEKPIVLKAESR 496
             GL L   P  +    R
Sbjct: 527 RFGLTLAPHPFNITISRR 544


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score =  121 bits (303), Expect = 2e-27
 Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 29/351 (8%)

Query: 160 LRREAETGKPVT-LKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP 218
           LR +AE G+ VT +  +F  YSM+ + +  +   +  L        EN+   L    ++ 
Sbjct: 36  LRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCL--------ENSIPQLTVEYIEA 87

Query: 219 FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIK---EGRLKETQKH---RVDFL 272
             L   +F        ++     PR +  F+ K  ++     +G  K +Q H   ++  +
Sbjct: 88  LELMFSMFK------TSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDI 141

Query: 273 QLMIDSQNSKDSET------HKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPD 326
           Q  +D                +AL+  E+ A     + AG +TTS  LS+ +Y LA HP+
Sbjct: 142 QYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPE 201

Query: 327 VQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGM 386
           VQQ V +EI   L  +  PT   V ++  +  ++ ETLRLFPV     RV ++D+ I G 
Sbjct: 202 VQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGY 261

Query: 387 FIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK-NKDNIDPYIYTPFGSGPRNCIGM 445
            IPKG  + +  Y   +  + +   ++F PER+ +K + D +D +   PFG G R+CIG 
Sbjct: 262 LIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGR 321

Query: 446 RFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496
           R A + + L ++++LQ+F  K   +T   +  +  GLL    PI ++  +R
Sbjct: 322 RIAELEIHLVVIQLLQHFEIKTSSQTN-AVHAKTHGLLTPGGPIHVRFVNR 371


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  119 bits (299), Expect = 5e-27
 Identities = 129/488 (26%), Positives = 214/488 (43%), Gaps = 40/488 (8%)

Query: 12  WLLLAVSLILL-YLYGTRTHGLFKK-----LGIPGPTPLPFLGNALSFRKGYWTFDMECY 65
           W L+A+ L+ L YL+  +      K     L +P    LPFL         ++       
Sbjct: 2   WELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQ---- 57

Query: 66  KKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKN---AISIAE 122
           KKY  ++ +    +  + +    + K VL+K+    F+ R     +    N    I+ A+
Sbjct: 58  KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKD-FSGRPQMATLDIASNNRKGIAFAD 116

Query: 123 D-EEWKRIRSLLSPTFTSGKL--KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAY 179
               W+  R L   TF   K   +++  II Q    L   L      G+ + +       
Sbjct: 117 SGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLA--THNGQSIDISFPVFVA 174

Query: 180 SMDVITSTSFGVS-------IDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPI 232
             +VI+   F  S       ++ + N  +  ++N  K    + L   V  +K+FP  T  
Sbjct: 175 VTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK----DSLVDLVPWLKIFPNKT-- 228

Query: 233 LEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFL---QLMIDSQNSKDSETHKA 289
           LE L   V  R     L K ++  KE    ++  + +D L   ++  D+ N+   +  + 
Sbjct: 229 LEKLKSHVKIRN--DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286

Query: 290 LSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDT 349
           LSD  ++        AG ETT+SV+ + +  L  +P V++K+ +EID  +     PT   
Sbjct: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346

Query: 350 VLQLEYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYW 408
             +L  L+  + E LRL PVA M +      D  I    + KG  V+I  + LHH+ K W
Sbjct: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406

Query: 409 TEPEKFLPERF-SKKNKDNIDPYI-YTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466
            +P++F+PERF +      I P + Y PFG+GPR+CIG   A   + L +  +LQ F  +
Sbjct: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466

Query: 467 PCKETQIP 474
              + Q+P
Sbjct: 467 VPDDGQLP 474


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.139    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,489,486
Number of Sequences: 37866
Number of extensions: 813300
Number of successful extensions: 1919
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1693
Number of HSP's gapped (non-prelim): 117
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.