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Search of human proteins with 4503213
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide
1 [Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 1032 0.0
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ... 365 e-101
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 299 5e-81
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 245 6e-65
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid... 236 5e-62
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide... 212 7e-55
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid... 210 3e-54
gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1... 181 1e-45
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid... 181 1e-45
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide... 146 5e-35
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 145 6e-35
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 140 4e-33
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 125 1e-28
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 115 7e-26
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 114 2e-25
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 112 8e-25
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 111 1e-24
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 110 2e-24
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 110 4e-24
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 107 2e-23
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 106 6e-23
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 105 1e-22
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 105 1e-22
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 103 3e-22
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ... 102 6e-22
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 102 6e-22
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 102 1e-21
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 102 1e-21
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ... 102 1e-21
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ... 102 1e-21
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 1032 bits (2668), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR 60
MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR
Sbjct: 1 MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR 60
Query: 61 LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR 120
LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR
Sbjct: 61 LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR 120
Query: 121 QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP 180
QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP
Sbjct: 121 QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP 180
Query: 181 ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH 240
ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH
Sbjct: 181 ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH 240
Query: 241 WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE 300
WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE
Sbjct: 241 WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE 300
Query: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 361 ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA 420
ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA 420
Query: 421 QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP
Sbjct: 421 QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
Query: 481 EPGAAPVRPKTRTVLVPERSINLQFLDR 508
EPGAAPVRPKTRTVLVPERSINLQFLDR
Sbjct: 481 EPGAAPVRPKTRTVLVPERSINLQFLDR 508
>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
precursor [Homo sapiens]
Length = 531
Score = 365 bits (936), Expect = e-101
Identities = 199/494 (40%), Positives = 285/494 (57%), Gaps = 16/494 (3%)
Query: 22 GASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFG 81
GA G R +RSL +IP F +LF +G +LH+LQV A +GP+W++ G
Sbjct: 45 GAGPGVRR---RQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLG 101
Query: 82 TVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLL 141
V +A+ L+E+++RQEG P R W EHR G T EG W +LR L
Sbjct: 102 PQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQAL 161
Query: 142 APLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAV 201
LL+P AA Y N V+ D + RL + R V D+A FY F LE I +
Sbjct: 162 NQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQ-VSDMAQLFYYFALEAICYI 220
Query: 202 LLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMF 261
L R+GCL+ +P DT TF+R++G +F ++L +P W R ++P W R W+ +F
Sbjct: 221 LFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPF-WKRYLDGWNAIF 279
Query: 262 AFAQRHVERR--EAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGV 319
+F ++ ++ + + EA ++ G ++ +L L +L + +G++ ELL+AGV
Sbjct: 280 SFGKKLIDEKLEDMEAQLQAAGPD--GIQVSGYLHFLLASGQLSPREAMGSLPELLMAGV 337
Query: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379
DT SNTL+WALY LS+ PE+Q ALH E+ + G P + +PLLKAV+KE LR
Sbjct: 338 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQ--VPQHKDFAHMPLLKAVLKETLR 395
Query: 380 LYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWL--GEG 437
LYPVVP NSR+ +K+I V ++ PKNT CHY SRDP F EP SF+P RWL +
Sbjct: 396 LYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQP 455
Query: 438 PTP---HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494
TP HPF S+PFG+G R+C+GRR+AELE+Q+ LA+++ ++V P ++ R V
Sbjct: 456 ATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIV 515
Query: 495 LVPERSINLQFLDR 508
LVP + + LQFL R
Sbjct: 516 LVPNKKVGLQFLQR 529
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 299 bits (765), Expect = 5e-81
Identities = 159/379 (41%), Positives = 230/379 (60%), Gaps = 15/379 (3%)
Query: 137 LRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLE 196
+RS+L +L+P+ A Y+G +N V+ DL++R+ R + V +V F+K+ +E
Sbjct: 1 MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGET-VTNVNDLFFKYSME 59
Query: 197 GIAAVLLGSRLGCLEAQVPPDTETFIRAVG---SVFVSTLLTMAMPHWLRHLVPGPWGRL 253
G+A +L SRLGCLE +P T +I A+ S+F +++ A+P WLR +P PW
Sbjct: 60 GVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREF 119
Query: 254 CRDWDQMFAFAQRHVER--REAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNV 311
CR WD +F F+Q HV+ R+ + M G + SG LT+ + L Q I NV
Sbjct: 120 CRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRV-----SGGLLTYLFLSQALTLQEIYANV 174
Query: 312 TELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLK 371
TE+LLAGVDT S TLSW +Y L+RHPEVQ ++ EI L G P+A + ++PL++
Sbjct: 175 TEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNL--GERHVPTAADVPKVPLVR 232
Query: 372 AVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPA 431
A++KE LRL+PV+PGN RV +D+ +G Y+IPK T + LCHYATS FP FRP
Sbjct: 233 ALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPE 292
Query: 432 RWLGEGPTPH--PFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRP 489
RWL +G F S+PFG G RSC+GRR+AELE+ + + Q+L HFE++ V
Sbjct: 293 RWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHA 352
Query: 490 KTRTVLVPERSINLQFLDR 508
KT +L P I+++F++R
Sbjct: 353 KTHGLLTPGGPIHVRFVNR 371
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 245 bits (626), Expect = 6e-65
Identities = 161/481 (33%), Positives = 238/481 (49%), Gaps = 26/481 (5%)
Query: 35 RSLADIPGPSTPSFLAELF---CKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAP 91
++ A +PGP++ L L KGGL + H+ V+ +G ++ G+ +V++ +P
Sbjct: 53 QNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSP 112
Query: 92 ALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAA 151
L+E L R E P+R PW +R R+ GLL EGE+WQR+RS L++P
Sbjct: 113 CLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEV 172
Query: 152 ARYAGTLNNVVCDLVRRLRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208
+ +N V+ D + R+ +RG V D+ E K+ E I VL R G
Sbjct: 173 MKLDNKINEVLADFMGRIDELCDERGH-------VEDLYSELNKWSFESICLVLYEKRFG 225
Query: 209 CLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRH 267
L+ + FI A+ ++ + M P L + L W WD +F +
Sbjct: 226 LLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKAC 285
Query: 268 VERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLS 327
++ R + + QP D + + L ++EL A VTEL LA V+T +N+L
Sbjct: 286 IDNRLEKYSQ----QPSADFLCDIYHQNRLSKKELYAA-----VTELQLAAVETTANSLM 336
Query: 328 WALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGN 387
W LY LSR+P+VQ L EI + L + P A L +P LKA +KE +RL P VP
Sbjct: 337 WILYNLSRNPQVQQKLLKEIQSVLP--ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT 394
Query: 388 SRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLP 447
+R DK +G+Y +PK T++ L F + + FRP RWL E +PFA LP
Sbjct: 395 TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLP 454
Query: 448 FGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLD 507
FG GKR C+GRRLAEL+L +AL I+ +++Q PV LVP R + + F
Sbjct: 455 FGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN-EPVEMLHSGTLVPSRELPIAFCQ 513
Query: 508 R 508
R
Sbjct: 514 R 514
>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform a precursor [Homo sapiens]
Length = 521
Score = 236 bits (601), Expect = 5e-62
Identities = 156/474 (32%), Positives = 237/474 (50%), Gaps = 11/474 (2%)
Query: 35 RSLADIPGPSTPSFLA--ELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPA 92
R +IP P +L + + G ++H VQ +GP++ G V +VYV P
Sbjct: 46 RPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPE 105
Query: 93 LVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAA 152
V L + EGP PER PW + + QR G+L + W++ R L ++ P+A
Sbjct: 106 DVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATK 165
Query: 153 RYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEA 212
+ L+ V D V L R R + G D++ + ++F E I V+ G R G LE
Sbjct: 166 NFLPLLDAVSRDFVSVLHR-RIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEE 224
Query: 213 QVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLV-PGPWGRLCRDWDQMFAFAQRHVERR 271
V P+ + FI A+ +F +++ + +P L L W WD +F+ A + +
Sbjct: 225 VVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNF 284
Query: 272 EAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALY 331
E +R G D L L ++ + I NVTE+L GVDT S TL W LY
Sbjct: 285 YWE--LRQKGSVHHDYRG--ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340
Query: 332 ELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVP 391
E++R+ +VQ L +E+ AA AT+L +PLLKA +KE LRL+P+ R
Sbjct: 341 EMARNLKVQDMLRAEVLAARHQAQG--DMATMLQLVPLLKASIKETLRLHPISVTLQRYL 398
Query: 392 DKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFG 451
D+ + DY+IP TLV + YA R+P F +P +F P RWL + F +L FG+G
Sbjct: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 458
Query: 452 KRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQF 505
R C+GRR+AELE+ + L +L +F V+ + + V +L+PE+ I+ F
Sbjct: 459 VRQCLGRRIAELEMTIFLINMLENFRVEIQ-HLSDVGTTFNLILMPEKPISFTF 511
>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 503
Score = 212 bits (539), Expect = 7e-55
Identities = 146/435 (33%), Positives = 208/435 (47%), Gaps = 16/435 (3%)
Query: 49 LAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERC 108
L +++ + G LH Q GP++ G V V P VE+L + + P R
Sbjct: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111
Query: 109 SFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRR 168
S PW +R+ R CG+ G EW+ R L P +L P A R+ ++ V D +
Sbjct: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
Query: 169 LRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAV 225
L++ Q RG+ L DV + + +E L G RLG + + F+ A+
Sbjct: 172 LKKKVLQNARGS----LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227
Query: 226 GSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPE 284
+F ST+ M MP L R P W WD +F + +++ E A +P+
Sbjct: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF---SRPQ 284
Query: 285 KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALH 344
+ A L L EL +I N EL VDT L L+EL+R+P VQ AL
Sbjct: 285 QYTSIVAEL---LLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALR 341
Query: 345 SEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPK 404
E AA + S AT ++LPLL+A +KE LRLYPV RV D+ + +Y IP
Sbjct: 342 QESLAAAASISEHPQKAT--TELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPA 399
Query: 405 NTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELE 464
TLV + Y+ R+PA FP P + P RWL + F +PFGFG R C+GRRLAE E
Sbjct: 400 GTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE 459
Query: 465 LQMALAQILTHFEVQ 479
+ + L +L H +V+
Sbjct: 460 MLLLLHHVLKHLQVE 474
>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
precursor [Homo sapiens]
Length = 503
Score = 210 bits (534), Expect = 3e-54
Identities = 145/435 (33%), Positives = 212/435 (48%), Gaps = 16/435 (3%)
Query: 49 LAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERC 108
L +++ + G LH Q GP++ + G R V V P VE+L + + P R
Sbjct: 52 LLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRM 111
Query: 109 SFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRR 168
PW +R+ R CG+ G EW+ R L P +L P+A R+ ++ V D +
Sbjct: 112 ILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQA 171
Query: 169 LRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAV 225
L++ Q RG+ L DV + + +E L G RLG + + F+ A+
Sbjct: 172 LKKKVLQNARGS----LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227
Query: 226 GSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPE 284
+F ST+ M MP L R + P W WD +F + +++ E A +P+
Sbjct: 228 EVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFN---RPQ 284
Query: 285 KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALH 344
A L L + EL ++I N EL VDT + L L+EL+R+P+VQ L
Sbjct: 285 HYTGIVAEL---LLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILR 341
Query: 345 SEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPK 404
E AA + S AT ++LPLL+A +KE LRLYPV RV D+ + +Y IP
Sbjct: 342 QESLAAAASISEHPQKAT--TELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPA 399
Query: 405 NTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELE 464
TLV + Y+ R+ A FP P + P RWL + F +PFGFG R C+GRRLAE E
Sbjct: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459
Query: 465 LQMALAQILTHFEVQ 479
+ + L +L HF V+
Sbjct: 460 MLLLLHHVLKHFLVE 474
>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 448
Score = 181 bits (459), Expect = 1e-45
Identities = 126/407 (30%), Positives = 194/407 (47%), Gaps = 25/407 (6%)
Query: 35 RSLADIPGPSTPSFLAELF---CKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAP 91
++ A +PGP++ L L KGGL + H+ V+ +G ++ G+ +V++ +P
Sbjct: 53 QNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSP 112
Query: 92 ALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAA 151
L+E L R E P+R PW +R R+ GLL EGE+WQR+RS L++P
Sbjct: 113 CLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEV 172
Query: 152 ARYAGTLNNVVCDLVRRLRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208
+ +N V+ D + R+ +RG V D+ E K+ E I VL R G
Sbjct: 173 MKLDNKINEVLADFMGRIDELCDERGH-------VEDLYSELNKWSFESICLVLYEKRFG 225
Query: 209 CLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRH 267
L+ + FI A+ ++ + M P L + L W WD +F +
Sbjct: 226 LLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKAC 285
Query: 268 VERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLS 327
++ R + + QP D + + L ++EL A VTEL LA V+T +N+L
Sbjct: 286 IDNRLEKYSQ----QPSADFLCDIYHQNRLSKKELYAA-----VTELQLAAVETTANSLM 336
Query: 328 WALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGN 387
W LY LSR+P+VQ L EI + L + P A L +P LKA +KE +RL P VP
Sbjct: 337 WILYNLSRNPQVQQKLLKEIQSVLP--ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT 394
Query: 388 SRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWL 434
+R DK +G+Y +PK + AT +P + + P+R L
Sbjct: 395 TRTLDKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSREL 441
>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform b [Homo sapiens]
Length = 363
Score = 181 bits (459), Expect = 1e-45
Identities = 122/361 (33%), Positives = 185/361 (51%), Gaps = 9/361 (2%)
Query: 146 LRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGS 205
+ P+A + L+ V D V L R R + G D++ + ++F E I V+ G
Sbjct: 1 MAPEATKNFLPLLDAVSRDFVSVLHR-RIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 59
Query: 206 RLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLV-PGPWGRLCRDWDQMFAFA 264
R G LE V P+ + FI A+ +F +++ + +P L L W WD +F+ A
Sbjct: 60 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA 119
Query: 265 QRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSN 324
+ + E +R G D L L ++ + I NVTE+L GVDT S
Sbjct: 120 DIYTQNFYWE--LRQKGSVHHDYRG--ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSM 175
Query: 325 TLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVV 384
TL W LYE++R+ +VQ L +E+ AA AT+L +PLLKA +KE LRL+P+
Sbjct: 176 TLQWHLYEMARNLKVQDMLRAEVLAARHQAQG--DMATMLQLVPLLKASIKETLRLHPIS 233
Query: 385 PGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFA 444
R D+ + DY+IP TLV + YA R+P F +P +F P RWL + F
Sbjct: 234 VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFR 293
Query: 445 SLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQ 504
+L FG+G R C+GRR+AELE+ + L +L +F V+ + + V +L+PE+ I+
Sbjct: 294 NLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ-HLSDVGTTFNLILMPEKPISFT 352
Query: 505 F 505
F
Sbjct: 353 F 353
>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 437
Score = 146 bits (368), Expect = 5e-35
Identities = 114/363 (31%), Positives = 164/363 (45%), Gaps = 16/363 (4%)
Query: 49 LAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERC 108
L +++ + G LH Q GP++ G V V P VE+L + + P R
Sbjct: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111
Query: 109 SFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRR 168
S PW +R+ R CG+ G EW+ R L P +L P A R+ ++ V D +
Sbjct: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
Query: 169 LRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAV 225
L++ Q RG +L DV + + +E L G RLG + + F+ A+
Sbjct: 172 LKKKVLQNARG----SLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227
Query: 226 GSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPE 284
+F ST+ M MP L R P W WD +F + +++ E A +P+
Sbjct: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF---SRPQ 284
Query: 285 KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALH 344
+ A L L EL +I N EL VDT L L+EL+R+P VQ AL
Sbjct: 285 QYTSIVAEL---LLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALR 341
Query: 345 SEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPK 404
E AA + S AT ++LPLL+A +KE LRLYPV RV D+ + +Y IP
Sbjct: 342 QESLAAAASISEHPQKAT--TELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPA 399
Query: 405 NTL 407
L
Sbjct: 400 GVL 402
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 145 bits (367), Expect = 6e-35
Identities = 129/480 (26%), Positives = 218/480 (45%), Gaps = 41/480 (8%)
Query: 40 IPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLR 99
IPGP+ L + L + + +G +W G + + + P ++ +L
Sbjct: 38 IPGPTPLPLLGNVLSYR--QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLV 95
Query: 100 QEGPRPERCSFSPWTEHRRCRQ---RACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAG 156
+E +S +T R + AE EEW+R+RSLL+P + +
Sbjct: 96 KE-------CYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFP- 147
Query: 157 TLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPP 216
+ LVR LRR+ +G P ++D+ G + ++ I G + L P
Sbjct: 148 IIAQYGDVLVRNLRREAEKGK--PVTLKDIFGAY---SMDVITGTSFGVNIDSLNNPQDP 202
Query: 217 ---DTETFIRA--VGSVFVSTLLTMAMPHWLRHLVPGPWGR-----LCRDWDQMFAFAQR 266
T+ F++ + +F+S +L + L + + L + ++M
Sbjct: 203 FVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN 262
Query: 267 HVERREAE-AAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325
++ + + Q K+ ES L+ EL AQSI+ + AG +T S+
Sbjct: 263 DKQKHRLDFLQLMIDSQNSKETESHKALSDL----ELAAQSII-----FIFAGYETTSSV 313
Query: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385
LS+ LYEL+ HP+VQ L EI A L + A P+ + Q+ L VV E LRL+PV
Sbjct: 314 LSFTLYELATHPDVQQKLQKEIDAVLP--NKAPPTYDAVVQMEYLDMVVNETLRLFPVAI 371
Query: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFAS 445
R KD+ + IPK ++V + YA DP + EP FRP R+ + + P+
Sbjct: 372 RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY 431
Query: 446 LPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP-EPGAAPVRPKTRTVLVPERSINLQ 504
PFG G R+C+G R A + +++AL ++L +F +P + P++ T+ +L PE+ I L+
Sbjct: 432 TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLK 491
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 140 bits (352), Expect = 4e-33
Identities = 133/493 (26%), Positives = 220/493 (44%), Gaps = 58/493 (11%)
Query: 40 IPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLR 99
IPGP+ FL + + +++ +G VW G + + P +++ +L
Sbjct: 38 IPGPTPLPFLGNILSYHKGFCMFDMECH--KKYGKVWGFYDGQQPVLAITDPDMIKTVLV 95
Query: 100 QEGPRPERCSFSPWTEHRRCRQ---RACGLLTAEGEEWQRLRSLLAPLLLRPQAA----- 151
+E +S +T R + AE EEW+RLRSLL+P +
Sbjct: 96 KE-------CYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPI 148
Query: 152 -ARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCL 210
A+Y L VR LRR+ TG P ++DV G + ++ I + G + L
Sbjct: 149 IAQYGDVL-------VRNLRREAE--TGKPVTLKDVFGAY---SMDVITSTSFGVNIDSL 196
Query: 211 EAQVPPDTETFIRAVGSVFVSTL-LTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVE 269
P E + + F+ L++ + +L ++ +C ++ F ++ V+
Sbjct: 197 NNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVL--NICVFPREVTNFLRKSVK 254
Query: 270 RREAEAA------------MRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLA 317
R + + Q K+ ES L+ EL AQSI+ + A
Sbjct: 255 RMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDL----ELVAQSII-----FIFA 305
Query: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377
G +T S+ LS+ +YEL+ HP+VQ L EI A L + A P+ + Q+ L VV E
Sbjct: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP--NKAPPTYDTVLQMEYLDMVVNET 363
Query: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437
LRL+P+ RV KD+ + IPK +V + YA RDP + EP F P R+ +
Sbjct: 364 LRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423
Query: 438 -PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP-EPGAAPVRPKTRTVL 495
P+ PFG G R+C+G R A + +++AL ++L +F +P + P++ +L
Sbjct: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483
Query: 496 VPERSINLQFLDR 508
PE+ + L+ R
Sbjct: 484 QPEKPVVLKVESR 496
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 125 bits (313), Expect = 1e-28
Identities = 114/395 (28%), Positives = 181/395 (45%), Gaps = 42/395 (10%)
Query: 129 AEGEEWQRLRSLLAPLLLRPQAA------ARYAGTLNNVVCDLVRRLRRQRGRGTGPPAL 182
AE EEW+R+RSLL+P + A+Y L VR LRR+ TG P
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVL-------VRNLRREAE--TGKPVT 171
Query: 183 VRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPP---DTETFIRA------VGSVFVSTL 233
++ V G + ++ I + G + L P +T+ +R V S+ V
Sbjct: 172 LKHVFGAY---SMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPF 228
Query: 234 LTMAMPHWLRHLVPGPW-GRLCRDWDQMFAFAQRHVERREAE-AAMRNGGQPEKDLESGA 291
LT + + P L + Q+ + ++ + + Q KD E+
Sbjct: 229 LTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHK 288
Query: 292 HLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAAL 351
L+ EL AQSI+ + AG +T S+ LS+ +YEL+ HP+VQ + EI L
Sbjct: 289 ALSDL----ELMAQSII-----FIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL 339
Query: 352 SPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLC 411
+ A P+ + QL L VV E LRL+PV RV KD+ + IPK +V +
Sbjct: 340 P--NKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIP 397
Query: 412 HYATSRDPAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALA 470
Y DP + EP F P R+ + P+ PFG G R+C+G R A + +++AL
Sbjct: 398 SYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALV 457
Query: 471 QILTHFEVQP-EPGAAPVRPKTRTVLVPERSINLQ 504
++L +F +P + P++ + +L+ E+ I L+
Sbjct: 458 RVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLK 492
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 115 bits (289), Expect = 7e-26
Identities = 127/485 (26%), Positives = 206/485 (42%), Gaps = 50/485 (10%)
Query: 40 IPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLR 99
IPGP+ FL + L L + +G +W G + + P +++ +L
Sbjct: 38 IPGPTPLPFLGTILFY--LRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLV 95
Query: 100 QEGPRPERCSFSPWTEHRRCRQRA---CGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAG 156
+E +S +T L AE EEW+R+R+LL+P +
Sbjct: 96 KE-------CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFK-EMVP 147
Query: 157 TLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPP 216
++ LVR LR++ ++ F + ++ I L G L L P
Sbjct: 148 IISQCGDMLVRSLRQEAENSKSI-----NLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 217 DTETFIRAVGSVFVST--LLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAE 274
+ + + F+ LL P G +D + F + +ER + E
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD---VTHFLKNSIERMK-E 258
Query: 275 AAMRN-------------GGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDT 321
+ +++ Q K+ +S L+ EL AQSI+ ++ A DT
Sbjct: 259 SRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL----ELVAQSII-----IIFAAYDT 309
Query: 322 VSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLY 381
S TL + +YEL+ HP+VQ L EI A L + A + L Q+ L VV E LRL+
Sbjct: 310 TSTTLPFIMYELATHPDVQQKLQEEIDAVLP--NKAPVTYDALVQMEYLDMVVNETLRLF 367
Query: 382 PVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG-PTP 440
PVV +RV KDI + IPK V + YA DP + EP F P R+ + +
Sbjct: 368 PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSI 427
Query: 441 HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP-EPGAAPVRPKTRTVLVPER 499
+ +PFG G R+C+G R A +++A+ + L +F +P + P++ +L PE+
Sbjct: 428 DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEK 487
Query: 500 SINLQ 504
I L+
Sbjct: 488 PIVLK 492
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 114 bits (285), Expect = 2e-25
Identities = 111/411 (27%), Positives = 173/411 (42%), Gaps = 65/411 (15%)
Query: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
GLLT+ G +W+ R +L P + +N LV++L + + +
Sbjct: 134 GLLTSTGNKWRSRRKMLTPTF-HFTILEDFLDIMNEQANILVKKLEKH---------INQ 183
Query: 185 DVAGEFYKF---GLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH- 240
+ F+ L+ I +G +G AQ D+E ++RAV + + MP
Sbjct: 184 EAFNCFFYITLCALDIICETAMGKNIG---AQSNDDSE-YVRAVYRMSEMIFRRIKMPWL 239
Query: 241 WLRHLVPGPWGRLCRD-WDQMFAFAQRHVERREAEAAMRN-------------GGQPEKD 286
WL W + ++ W+ + H A N G P K+
Sbjct: 240 WL-----DLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKN 294
Query: 287 L-------------ESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYEL 333
+ G L+H REE V + G DT + ++W+LY L
Sbjct: 295 KRRAFLDLLLSVTDDEGNRLSHEDIREE---------VDTFMFEGHDTTAAAINWSLYLL 345
Query: 334 SRHPEVQTALHSEITAALSPGSSAYPSATV--LSQLPLLKAVVKEVLRLYPVVPGNSRVP 391
+PEVQ + E+ G S P ATV L +L L+ V+KE LRL+P VP +R
Sbjct: 346 GSNPEVQKKVDHELDDVF--GKSDRP-ATVEDLKKLRYLECVIKETLRLFPSVPLFARSV 402
Query: 392 DKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPT-PHPFASLPFGF 450
+D V Y + K T + YA RDP FP P F+P R+ E HP+A +PF
Sbjct: 403 SEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSA 462
Query: 451 GKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSI 501
G R+C+G++ A +E + L+ IL HF ++ + + + +L P I
Sbjct: 463 GPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGI 513
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 112 bits (280), Expect = 8e-25
Identities = 126/486 (25%), Positives = 204/486 (41%), Gaps = 51/486 (10%)
Query: 40 IPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLR 99
IPGP+ FL + L L + +G +W G + + P +++ +L
Sbjct: 38 IPGPTPLPFLGTILFY--LRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLV 95
Query: 100 QEGPRPERCSFSPWTEHRRCRQRA---CGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAG 156
+E +S +T L AE EEW+R+R+LL+P +
Sbjct: 96 KE-------CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFK-EMVP 147
Query: 157 TLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPP 216
++ LVR LR++ ++ F + ++ I L G L L P
Sbjct: 148 IISQCGDMLVRSLRQEAENSKSI-----NLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 217 DTETFIRAVGSVFVST--LLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAE 274
+ + + F+ LL P G +D + F + +ER + E
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD---VTHFLKNSIERMK-E 258
Query: 275 AAMRN-------------GGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDT 321
+ +++ Q K+ +S L+ EL AQSI+ ++ A DT
Sbjct: 259 SRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL----ELVAQSII-----IIFAAYDT 309
Query: 322 VSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLY 381
S TL + +YEL+ HP+VQ L EI A L + A + L Q+ L VV E LRL+
Sbjct: 310 TSTTLPFIMYELATHPDVQQKLQEEIDAVLP--NKAPVTYDALVQMEYLDMVVNETLRLF 367
Query: 382 PVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGE--GPT 439
PVV +RV KDI + IPK V + YA DP + EP F P + +
Sbjct: 368 PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDS 427
Query: 440 PHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP-EPGAAPVRPKTRTVLVPE 498
+ +PFG G R+C+G R A +++A+ + L +F +P + P++ +L PE
Sbjct: 428 IDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPE 487
Query: 499 RSINLQ 504
+ I L+
Sbjct: 488 KPIVLK 493
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 111 bits (278), Expect = 1e-24
Identities = 71/204 (34%), Positives = 102/204 (50%), Gaps = 5/204 (2%)
Query: 302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSA 361
L + + V + G DT ++ +SW LY L+ HP+ Q EI + L G+S +
Sbjct: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASI--TW 363
Query: 362 TVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRDPA 420
L Q+P +KE LRLYP VPG R + D +PK +V L Y +P
Sbjct: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423
Query: 421 QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
+P P F P R+ G H A LPF G R+C+G++ A EL++A A L FE+ P
Sbjct: 424 VWPNPEVFDPFRF-APGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
Query: 481 EPGAAPVRPKTRTVLVPERSINLQ 504
+P P+ P R VL + I+L+
Sbjct: 483 DPTRIPI-PIARLVLKSKNGIHLR 505
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 110 bits (276), Expect = 2e-24
Identities = 103/455 (22%), Positives = 183/455 (40%), Gaps = 41/455 (9%)
Query: 41 PGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELL-- 98
PGP FL F E+Q+ +G ++ G + V + L++E L
Sbjct: 45 PGPWRLPFLGNFFLVDFEQSHLEVQLF-VKKYGNLFSLELGDISAVLITGLPLIKEALIH 103
Query: 99 --RQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAAR-YA 155
+ G RP +P EH + GL+ + G+ W+ R L +
Sbjct: 104 MDQNFGNRP----VTPMREHIFKKN---GLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156
Query: 156 GTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVP 215
+ L ++ + G+ P + + I ++ G R ++
Sbjct: 157 ERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNI-------ICSITFGERFEYQDSWFQ 209
Query: 216 P-----DTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVER 270
D T++ A + + + W+ +PGP L +W ++ F +++
Sbjct: 210 QLLKLLDEVTYLEASKTCQLYNVFP-----WIMKFLPGPHQTLFSNWKKLKLFVSHMIDK 264
Query: 271 REAE---AAMRNGGQPE-KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTL 326
+ A R+ K++ F EE +++ + +L AG +T S TL
Sbjct: 265 HRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEE----NLICSTLDLFFAGTETTSTTL 320
Query: 327 SWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPG 386
WAL ++ +PE+Q + +EI + G PS +P AV+ EV R+ ++P
Sbjct: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQ--PSTAARESMPYTNAVIHEVQRMGNIIPL 378
Query: 387 N-SRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFAS 445
N R D + Y +PK T++ A RDP ++ P++F P +L G A
Sbjct: 379 NVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAF 438
Query: 446 LPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
+PF GKR+C+G +LA EL + ++ F +P
Sbjct: 439 MPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP 473
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 110 bits (274), Expect = 4e-24
Identities = 120/463 (25%), Positives = 191/463 (41%), Gaps = 31/463 (6%)
Query: 31 HSARRSLADIPGPSTPSFL-AELFC-----KGGLSRLHELQVQGAAHFGPVWLASFGTVR 84
H AR IPGP PSFL L C + G L ++ + A +GPV +
Sbjct: 24 HRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKT 83
Query: 85 TVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLT-AEGEEWQRLRSLLAP 143
+V V +P V++ L + + R GL++ E W + R ++
Sbjct: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVI-D 142
Query: 144 LLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLL 203
L + T N LV L + T P ++D+ ++ +A
Sbjct: 143 LAFSRSSLVSLMETFNEKAEQLVEILEAKADGQT--PVSMQDM---LTYTAMDILAKAAF 197
Query: 204 GSRLGCL-EAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFA 262
G L AQ P + G L +P + L R R+ +
Sbjct: 198 GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL------REVRESIRFLR 251
Query: 263 FAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREE--LPAQSILGNVTELLLAGVD 320
R +R EA ++ G + D+ LT L EE + +L N +AG +
Sbjct: 252 QVGRDWVQRRREA-LKRGEEVPADI-----LTQILKAEEGAQDDEGLLDNFVTFFIAGHE 305
Query: 321 TVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRL 380
T +N L++ + ELSR PE+ L +E+ + GS Y L +L L V+KE LRL
Sbjct: 306 TSANHLAFTVMELSRQPEIVARLQAEVDEVI--GSKRYLDFEDLGRLQYLSQVLKESLRL 363
Query: 381 YPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP 440
YP G R+ +++ + +P NT + Y R F +P +F P R+ P P
Sbjct: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP 423
Query: 441 HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPG 483
F PF G RSC+G++ A++E+++ +A++L E + PG
Sbjct: 424 R-FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPG 465
>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
[Homo sapiens]
Length = 519
Score = 107 bits (268), Expect = 2e-23
Identities = 69/204 (33%), Positives = 101/204 (49%), Gaps = 5/204 (2%)
Query: 302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSA 361
L + + V + G DT ++ +SW LY L+ HP+ Q EI L G+S +
Sbjct: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASI--TW 363
Query: 362 TVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRDPA 420
L Q+P +KE LRLYP VPG R + D +PK +V L Y +P
Sbjct: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423
Query: 421 QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
+P F P+R+ G H A LPF G R+C+G++ A +L++A A L FE+ P
Sbjct: 424 VWPNLEVFDPSRF-APGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP 482
Query: 481 EPGAAPVRPKTRTVLVPERSINLQ 504
+P P+ P R VL + I+L+
Sbjct: 483 DPTRIPI-PMARLVLKSKNGIHLR 505
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 106 bits (264), Expect = 6e-23
Identities = 80/266 (30%), Positives = 134/266 (50%), Gaps = 16/266 (6%)
Query: 231 STLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDL--- 287
S +L + + WL +L GP+ L + + +F ++ ++ + E+ R Q D+
Sbjct: 265 SQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQ-ESLDRENPQDFIDMYLL 323
Query: 288 ---ESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALH 344
E + ++ F EE + + +L +AG DT +N+L W L +S +P+VQ +H
Sbjct: 324 HMEEERKNNSNSSFDEEY----LFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVH 379
Query: 345 SEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP-GNSRVPDKDIHVGDYIIP 403
EI + G++ PS T +Q+P +A + EV RL VVP + ++ + Y IP
Sbjct: 380 EEIERVI--GANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIP 437
Query: 404 KNTLVTLCHYATSRDPAQFPEPNSFRPARWL-GEGPTPHPFASLPFGFGKRSCMGRRLAE 462
K TL+ ++ RDPA + +P F P R+L +G +PFG GKR CMG +LA+
Sbjct: 438 KGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAK 497
Query: 463 LELQMALAQILTHFE-VQPEPGAAPV 487
+EL + ++ F PE P+
Sbjct: 498 MELFLMFVSLMQSFAFALPEDSKKPL 523
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 105 bits (261), Expect = 1e-22
Identities = 66/209 (31%), Positives = 104/209 (49%), Gaps = 3/209 (1%)
Query: 302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSA 361
L I+G L+AG + ++NTLS+A Y L+ +P+ Q L E+ A
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDV-FKEKHMAPEFC 385
Query: 362 TVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQ 421
++ LP L V+ E LR+YP +R +D V IP ++ + A DP
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445
Query: 422 FPEPNSFRPARWLGEGPTPH-PFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
+P P +F P R+ E H PF LPFG G RSC+G RL LE+++ L +L F Q
Sbjct: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
Query: 481 EPGA-APVRPKTRTVLVPERSINLQFLDR 508
P P++ ++++ L P+ + ++ + R
Sbjct: 506 CPETQVPLQLESKSALGPKNGVYIKIVSR 534
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 105 bits (261), Expect = 1e-22
Identities = 66/209 (31%), Positives = 104/209 (49%), Gaps = 3/209 (1%)
Query: 302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSA 361
L I+G L+AG + ++NTLS+A Y L+ +P+ Q L E+ A
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDV-FKEKHMAPEFC 385
Query: 362 TVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQ 421
++ LP L V+ E LR+YP +R +D V IP ++ + A DP
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445
Query: 422 FPEPNSFRPARWLGEGPTPH-PFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
+P P +F P R+ E H PF LPFG G RSC+G RL LE+++ L +L F Q
Sbjct: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
Query: 481 EPGA-APVRPKTRTVLVPERSINLQFLDR 508
P P++ ++++ L P+ + ++ + R
Sbjct: 506 CPETQVPLQLESKSALGPKNGVYIKIVSR 534
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 103 bits (258), Expect = 3e-22
Identities = 67/195 (34%), Positives = 98/195 (50%), Gaps = 5/195 (2%)
Query: 311 VTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLL 370
V+ LLAG DT++ ++SW LY L+ +PE Q E+ L GSS + L ++
Sbjct: 310 VSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSI--TWDQLGEMSYT 367
Query: 371 KAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRDPAQFPEPNSFR 429
+KE RL P VP SR K + D +P V L + +PA + P F
Sbjct: 368 TMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFD 427
Query: 430 PARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVR 488
P R+ E HP+A LPF G R+C+G+ A +EL++ +A IL HF V P+P P+
Sbjct: 428 PLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDP-TRPLT 486
Query: 489 PKTRTVLVPERSINL 503
+L P+ + L
Sbjct: 487 FPNHFILKPKNGMYL 501
>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
[Homo sapiens]
Length = 493
Score = 102 bits (255), Expect = 6e-22
Identities = 61/172 (35%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 311 VTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLL 370
V +L AG +T S TL + L L ++PE++ LH EI + P S P+ ++P +
Sbjct: 293 VADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGP--SRIPAIKDRQEMPYM 350
Query: 371 KAVVKEVLRLYPVVPGN-SRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFR 429
AVV E+ R +VP N +D Y+IPK T+V + D +FP+P F+
Sbjct: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410
Query: 430 PARWLGE-GPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
P +L E G + PF GKR C G LA +EL + L IL HF ++P
Sbjct: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 102 bits (255), Expect = 6e-22
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 2/184 (1%)
Query: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
+EL + I + G DT ++ LSW LY L+RHPE Q E+ L
Sbjct: 311 KELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEI 370
Query: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRD 418
L+QLP L +KE LRL+P +P +R +D+ + D +IPK + + +A +
Sbjct: 371 EWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHN 430
Query: 419 PAQFPEPNSFRPARWLGEGPTPH-PFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
P+ +P+P + P R+ E P A +PF G R+C+G++ A E+++ LA L F
Sbjct: 431 PSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFR 490
Query: 478 VQPE 481
+ P+
Sbjct: 491 ILPD 494
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 102 bits (253), Expect = 1e-21
Identities = 70/193 (36%), Positives = 97/193 (50%), Gaps = 9/193 (4%)
Query: 300 EELPAQSILGNV----TELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPG- 354
EE Q + G+V +LL+ G +T +NTLSWA+ L HPE+Q L E+ L PG
Sbjct: 241 EEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGA 300
Query: 355 SSAYPSATVLSQLPLLKAVVKEVLRLYPVVP-GNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
SS+ ++LPLL A + EVLRL PVVP + + Y IP+ T++
Sbjct: 301 SSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQ 360
Query: 414 ATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQIL 473
D + P+ F P R+L G +L FG G R C+G LA LEL + L ++L
Sbjct: 361 GAHLDETVWERPHEFWPDRFLEPGKNSR---ALAFGCGARVCLGEPLARLELFVVLTRLL 417
Query: 474 THFEVQPEPGAAP 486
F + P A P
Sbjct: 418 QAFTLLPSGDALP 430
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 102 bits (253), Expect = 1e-21
Identities = 70/193 (36%), Positives = 97/193 (50%), Gaps = 9/193 (4%)
Query: 300 EELPAQSILGNV----TELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPG- 354
EE Q + G+V +LL+ G +T +NTLSWA+ L HPE+Q L E+ L PG
Sbjct: 271 EEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGA 330
Query: 355 SSAYPSATVLSQLPLLKAVVKEVLRLYPVVP-GNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
SS+ ++LPLL A + EVLRL PVVP + + Y IP+ T++
Sbjct: 331 SSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQ 390
Query: 414 ATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQIL 473
D + P+ F P R+L G +L FG G R C+G LA LEL + L ++L
Sbjct: 391 GAHLDETVWERPHEFWPDRFLEPGKNSR---ALAFGCGARVCLGEPLARLELFVVLTRLL 447
Query: 474 THFEVQPEPGAAP 486
F + P A P
Sbjct: 448 QAFTLLPSGDALP 460
>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 2 [Homo sapiens]
Length = 443
Score = 102 bits (253), Expect = 1e-21
Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 17/276 (6%)
Query: 242 LRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREE 301
++HL PGP + + + F + VE + + P+ ++S L H E+
Sbjct: 176 MKHL-PGPQQQAFKLLQGLEDFIAKKVEHNQRTL---DPNSPQDFIDS--FLIHMQEEEK 229
Query: 302 LP-----AQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSS 356
P ++++ + L +AG +TVS TL + L +HPEV+ +H EI + G +
Sbjct: 230 NPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVI--GKN 287
Query: 357 AYPSATVLSQLPLLKAVVKEVLRLYPVVPGN-SRVPDKDIHVGDYIIPKNTLVTLCHYAT 415
P +++P ++AV+ E+ R V+P + +R KD D+ +PK T V +
Sbjct: 288 RQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSV 347
Query: 416 SRDPAQFPEPNSFRPARWLGE-GPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILT 474
RDP+ F P F P +L + G A +PF GKR+C G LA +EL + ++
Sbjct: 348 LRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ 407
Query: 475 HFEVQ--PEPGAAPVRPKTRTVLVPERSINLQFLDR 508
+F ++ P V PK R+ + FL R
Sbjct: 408 NFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR 443
>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 1 [Homo sapiens]
Length = 494
Score = 102 bits (253), Expect = 1e-21
Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 17/276 (6%)
Query: 242 LRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREE 301
++HL PGP + + + F + VE + + P+ ++S L H E+
Sbjct: 227 MKHL-PGPQQQAFKLLQGLEDFIAKKVEHNQRTL---DPNSPQDFIDS--FLIHMQEEEK 280
Query: 302 LP-----AQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSS 356
P ++++ + L +AG +TVS TL + L +HPEV+ +H EI + G +
Sbjct: 281 NPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVI--GKN 338
Query: 357 AYPSATVLSQLPLLKAVVKEVLRLYPVVPGN-SRVPDKDIHVGDYIIPKNTLVTLCHYAT 415
P +++P ++AV+ E+ R V+P + +R KD D+ +PK T V +
Sbjct: 339 RQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSV 398
Query: 416 SRDPAQFPEPNSFRPARWLGE-GPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILT 474
RDP+ F P F P +L + G A +PF GKR+C G LA +EL + ++
Sbjct: 399 LRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ 458
Query: 475 HFEVQ--PEPGAAPVRPKTRTVLVPERSINLQFLDR 508
+F ++ P V PK R+ + FL R
Sbjct: 459 NFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR 494
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,789,398
Number of Sequences: 37866
Number of extensions: 1065057
Number of successful extensions: 2988
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2717
Number of HSP's gapped (non-prelim): 111
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.