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Search of human proteins with 4502523
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
(2339 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 4717 0.0
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 2759 0.0
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 2693 0.0
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 2285 0.0
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 773 0.0
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 773 0.0
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 772 0.0
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 770 0.0
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 769 0.0
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 769 0.0
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 769 0.0
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1... 769 0.0
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 768 0.0
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 768 0.0
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 768 0.0
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1... 768 0.0
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1... 766 0.0
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1... 766 0.0
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 765 0.0
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1... 763 0.0
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 761 0.0
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 761 0.0
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 761 0.0
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1... 761 0.0
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 758 0.0
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 757 0.0
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 750 0.0
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 750 0.0
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1... 735 0.0
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 312 3e-84
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 4717 bits (12235), Expect = 0.0
Identities = 2339/2339 (100%), Positives = 2339/2339 (100%)
Query: 1 MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYN 60
MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYN
Sbjct: 1 MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYN 60
Query: 61 PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD 120
PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD
Sbjct: 61 PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD 120
Query: 121 GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA 180
GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA
Sbjct: 121 GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA 180
Query: 181 TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAII 240
TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAII
Sbjct: 181 TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAII 240
Query: 241 GLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNI 300
GLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNI
Sbjct: 241 GLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNI 300
Query: 301 LFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 360
LFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA
Sbjct: 301 LFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 360
Query: 361 KERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAA 420
KERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAA
Sbjct: 361 KERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAA 420
Query: 421 TKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVK 480
TKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVK
Sbjct: 421 TKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVK 480
Query: 481 AQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRS 540
AQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRS
Sbjct: 481 AQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRS 540
Query: 541 YFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVV 600
YFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVV
Sbjct: 541 YFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVV 600
Query: 601 SLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQIL 660
SLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQIL
Sbjct: 601 SLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQIL 660
Query: 661 TGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 720
TGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK
Sbjct: 661 TGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 720
Query: 721 DEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNL 780
DEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNL
Sbjct: 721 DEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNL 780
Query: 781 RASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAE 840
RASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAE
Sbjct: 781 RASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAE 840
Query: 841 APEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPP 900
APEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPP
Sbjct: 841 APEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPP 900
Query: 901 EARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRG 960
EARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRG
Sbjct: 901 EARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRG 960
Query: 961 GPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNH 1020
GPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNH
Sbjct: 961 GPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNH 1020
Query: 1021 QPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHI 1080
QPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHI
Sbjct: 1021 QPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHI 1080
Query: 1081 PVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLR 1140
PVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLR
Sbjct: 1081 PVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLR 1140
Query: 1141 RFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVI 1200
RFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVI
Sbjct: 1141 RFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVI 1200
Query: 1201 KMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLK 1260
KMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLK
Sbjct: 1201 KMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLK 1260
Query: 1261 TIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELER 1320
TIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELER
Sbjct: 1261 TIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELER 1320
Query: 1321 DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1380
DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE
Sbjct: 1321 DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1380
Query: 1381 EQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACI 1440
EQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACI
Sbjct: 1381 EQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACI 1440
Query: 1441 DFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYE 1500
DFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYE
Sbjct: 1441 DFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYE 1500
Query: 1501 LMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNN 1560
LMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNN
Sbjct: 1501 LMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNN 1560
Query: 1561 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1620
FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV
Sbjct: 1561 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1620
Query: 1621 FGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECG 1680
FGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECG
Sbjct: 1621 FGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECG 1680
Query: 1681 SDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAA 1740
SDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAA
Sbjct: 1681 SDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAA 1740
Query: 1741 CGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIR 1800
CGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIR
Sbjct: 1741 CGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIR 1800
Query: 1801 TALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMI 1860
TALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMI
Sbjct: 1801 TALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMI 1860
Query: 1861 FDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSL 1920
FDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSL
Sbjct: 1861 FDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSL 1920
Query: 1921 SNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSI 1980
SNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSI
Sbjct: 1921 SNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSI 1980
Query: 1981 TRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPD 2040
TRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPD
Sbjct: 1981 TRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPD 2040
Query: 2041 RPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRR 2100
RPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRR
Sbjct: 2041 RPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRR 2100
Query: 2101 ERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGP 2160
ERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGP
Sbjct: 2101 ERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGP 2160
Query: 2161 HPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSL 2220
HPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSL
Sbjct: 2161 HPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSL 2220
Query: 2221 PAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTF 2280
PAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTF
Sbjct: 2221 PAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTF 2280
Query: 2281 EEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDHWC 2339
EEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDHWC
Sbjct: 2281 EEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDHWC 2339
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 2759 bits (7153), Expect = 0.0
Identities = 1535/2548 (60%), Positives = 1765/2548 (69%), Gaps = 251/2548 (9%)
Query: 1 MVRFGDELGGRYGGPGGGERAR----GGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTM 56
M RFGDE+ RYGG G G A GG GAGG GG QPG + +YKQS+AQRARTM
Sbjct: 1 MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGG-QPGAQRMYKQSMAQRARTM 59
Query: 57 ALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQ 116
ALYNPIPV+QNC TVNRSLF+FSEDNVVRKYAK+ITEWPPFEYMILATIIANCIVLALEQ
Sbjct: 60 ALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQ 119
Query: 117 HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLT 176
HLPD DKTPMSERLDDTEPYFIGIFCFEAGIKIIALGF FHKGSYLRNGWNVMDFVVVLT
Sbjct: 120 HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLT 179
Query: 177 GILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236
GILAT GT+FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAM+PLLQIGLLLFFAIL+
Sbjct: 180 GILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILI 239
Query: 237 FAIIGLEFYMGKFHKACFPNSTD-AEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGIT 295
FAIIGLEFYMGKFH CF TD + PCG E PAR C T+C+ YW GPN GIT
Sbjct: 240 FAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGIT 299
Query: 296 NFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVL 355
FDNILFA+LTVFQCITMEGWTD+LYN+NDA+GNTWNWLYFIPLIIIGSFFMLNLVLGVL
Sbjct: 300 QFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVL 359
Query: 356 SGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDV 415
SGEFAKERERVENRRAFLKLRRQQQIERELNGY+EWI KAEEV+LAE++ + E++ P D
Sbjct: 360 SGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDA 419
Query: 416 LKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFI 475
L+R KKS+ DL++ EE ED+ AD+ +VGSPFARAS+KS K E+S++F +KE+ RF+I
Sbjct: 420 LRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYI 479
Query: 476 RRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYG 535
RRMVK Q+FYW VL +VALNTLCVA+VHYNQP L+ LY+AEF+FLGLF++EM +KMYG
Sbjct: 480 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 539
Query: 536 LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSL 595
LG R YF SSFNCFD GVI+GS+FEV+WA IKPG+SFGISVLRALRLLRIFKVTKYW+SL
Sbjct: 540 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 599
Query: 596 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILT 655
RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF + TP TNFDTFPAAI+T
Sbjct: 600 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT 659
Query: 656 VFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
VFQILTGEDWN VMY GI+SQGGV GM S YFIVLTLFGNYTLLNVFLAIAVDNLANA
Sbjct: 660 VFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANA 719
Query: 716 QELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQ--NSAKARSVWEQRAS 773
QELTKDE+E EEAANQKLALQKAKEVAEVSP+SAAN+SIA ++Q N A+SVWEQR S
Sbjct: 720 QELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTS 779
Query: 774 QLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGK 833
++R QNL AS EALY+EMDP+ER + A TRHLRPDMKTHLDRPLVV+ + +
Sbjct: 780 EMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSR 839
Query: 834 ARPEAAEAPEGV----DPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPH 889
A + G D R+ R+ D+ + P+ A P A S E E P
Sbjct: 840 AAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGR 899
Query: 890 RS--HSKEAA----GPPEARSERGRGPGP-------EGGRRHHRRGSPEEAAEREPRRHR 936
S H++E + G E +ERG+ P +GG R R GSP A+ E RRHR
Sbjct: 900 ESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHR 959
Query: 937 AHRHQDPSKECAGAKGERRARHRGGPR---AGPREAESGEEPARRHRARHKAQPAHEA-- 991
AHR P +E K ERRARHR G R G E E + RR R RH A +E
Sbjct: 960 AHRR--PGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDA 1017
Query: 992 --VEKETTEKEATEKE----------------------------AEIVEADKEKELRNHQ 1021
+KE + E + AE ++ K +L +
Sbjct: 1018 RREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAE 1077
Query: 1022 PREPHCDLETSG----------TVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMG--S 1069
PH L +G + GPM +P+ + P++A ++R G S
Sbjct: 1078 SAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPA-----MATNPQNAASRRTPNNPGNPS 1132
Query: 1070 QPPDP---------------------------NTIVHIPVMLTGPLGEATVVPSGNVD-- 1100
P P +T V IP PL V + N +
Sbjct: 1133 NPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPD 1192
Query: 1101 -LESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVV 1159
L + E KKE E DD GP+P+ PYSSMF LS TN LRR CHYI+ +RYFE+ IL+V
Sbjct: 1193 PLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMV 1252
Query: 1160 IALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLW 1219
IA+SSIALAAEDPV+ ++PRNN L+Y DY+FTGVFTFEMVIKMIDLGL+LH GAYFRDLW
Sbjct: 1253 IAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLW 1312
Query: 1220 NILDFIVVSGALVAFAFSG-SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNS 1278
NILDFIVVSGALVAFAF+G SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNS
Sbjct: 1313 NILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNS 1372
Query: 1279 LKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQP 1338
LKNV NILIVYMLFMFIFAV+AVQLFKGKFF+CTDESKE E+DCRG+YL YEK EV+A+
Sbjct: 1373 LKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARD 1432
Query: 1339 RQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVV 1398
R+WKKY+FHYDNVLWALLTLFTVSTGEGWP VLKHSVDAT+E QGPSPGYRME+SIFYVV
Sbjct: 1433 REWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVV 1492
Query: 1399 YFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQ 1458
YFVVFPFFFVNIFVALIIITFQEQGDK+M E SLEKNERACIDFAISAKPLTR+MPQN+Q
Sbjct: 1493 YFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQ 1552
Query: 1459 SFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMEC 1518
SFQY+ W FVVSPPFEY IMAMIALNT+VLMMKFY A YE L+ NIVFTS+FS+EC
Sbjct: 1553 SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLEC 1612
Query: 1519 VLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKL 1578
VLK++AFG+LNYFRDAWN+FDFVTVLGSITDILVTE NNFINLSFLRLFRAARLIKL
Sbjct: 1613 VLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG--NNFINLSFLRLFRAARLIKL 1670
Query: 1579 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD--------DDT 1630
LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI +D D+
Sbjct: 1671 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEF 1730
Query: 1631 SINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQAN--ATECGSDFAYFYF 1688
I HNNFRTF QALMLLFRSATGEAWH IMLSCLS + CD+ + ECG++FAYFYF
Sbjct: 1731 QITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYF 1790
Query: 1689 VSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYND 1748
VSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDE++RVWAEYDPAA GR+ Y D
Sbjct: 1791 VSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLD 1850
Query: 1749 MFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLA 1808
M++ML+HMSPPLGLGKKCPARVAYKRL+RM++P++ +D TVHF STLMALIRTAL+IK+A
Sbjct: 1851 MYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVA-DDNTVHFNSTLMALIRTALDIKIA 1909
Query: 1809 PAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNK 1868
G + Q DAELRKE+ +W NL QKTLDLLV PHK ++TVGK+YAA+MI ++Y+Q+K
Sbjct: 1910 KGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSK 1969
Query: 1869 -----TTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNG 1923
R++ + P +M P P+ + ST L G
Sbjct: 1970 AKKLQAMREEQDRTPLMFQRMEP---------------PSPTQEGGPGQNALPSTQLDPG 2014
Query: 1924 GAIQNQESGIKESVSWGTQRTQDAPHEARP-PLERGHSTEIPVGRSGALAVDVQMQSITR 1982
GA+ ESG+KES SW TQR Q+ + E+G T++P S + V+M+ + R
Sbjct: 2015 GALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMP--NSQPNSQSVEMREMGR 2072
Query: 1983 RG-PDGEPQPGLESQGRAASMPRLAAETQ------------PVTDASPMKRSISTLAQRP 2029
G D E +E QGRAASMPRL AE Q ++D SPMKRS S L P
Sbjct: 2073 DGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLG--P 2130
Query: 2030 RGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGL 2089
+ L + +R PP + HH RRRDR R+ E+ D+D + +
Sbjct: 2131 KARRLDDYSLERVPPEENQRHH-----QRRRDRSHRASERSLGRYTDVDTGLGTDLSMTT 2185
Query: 2090 PPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFY----SCDRFGGREPPKPKPSL 2145
G+ P+ +ER QERGR ++R+ + DR+ P +
Sbjct: 2186 QSGDLPS-----KERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARA 2240
Query: 2146 SSH--PTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITY 2203
SP+ G+E H QGS SV+GSP STSG STP R GRRQLPQTP TPRP ++Y
Sbjct: 2241 RDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTP-RRGRRQLPQTPSTPRPHVSY 2299
Query: 2204 --------------------------------KTANSSPIHF--------AGAQTSLPAF 2223
+ A S P + AG +
Sbjct: 2300 SPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGH 2359
Query: 2224 SPGRLSR--------GLSEHNALLQ----RDPLSQPLA----PGSR-----IGSD----- 2257
S GR R SE + R P S P PG R GSD
Sbjct: 2360 SSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEAD 2419
Query: 2258 -PYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHC 2316
P G ++ A + P S R+ R S + + H RR+PNGY+
Sbjct: 2420 GPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHG-RRLPNGYYP 2478
Query: 2317 TLGLS--SGGRARHSYHHP---DQDHWC 2339
GL+ G +R H P D WC
Sbjct: 2479 AHGLARPRGPGSRKGLHEPYSESDDDWC 2506
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 2693 bits (6980), Expect = 0.0
Identities = 1458/2301 (63%), Positives = 1671/2301 (72%), Gaps = 178/2301 (7%)
Query: 1 MVRFGDELGGRYGGPGGGERAR----GGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTM 56
M RFGDE+ RYGG G G A GG GAGG GG QPG + +YKQS+AQRARTM
Sbjct: 1 MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGG-QPGAQRMYKQSMAQRARTM 59
Query: 57 ALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQ 116
ALYNPIPV+QNC TVNRSLF+FSEDNVVRKYAK+ITEWPPFEYMILATIIANCIVLALEQ
Sbjct: 60 ALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQ 119
Query: 117 HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLT 176
HLPD DKTPMSERLDDTEPYFIGIFCFEAGIKIIALGF FHKGSYLRNGWNVMDFVVVLT
Sbjct: 120 HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLT 179
Query: 177 GILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236
GILAT GT+FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAM+PLLQIGLLLFFAIL+
Sbjct: 180 GILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILI 239
Query: 237 FAIIGLEFYMGKFHKACFPNSTD-AEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGIT 295
FAIIGLEFYMGKFH CF TD + PCG E PAR C T+C+ YW GPN GIT
Sbjct: 240 FAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGIT 299
Query: 296 NFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVL 355
FDNILFA+LTVFQCITMEGWTD+LYN+NDA+GNTWNWLYFIPLIIIGSFFMLNLVLGVL
Sbjct: 300 QFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVL 359
Query: 356 SGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLD- 414
SGEFAKERERVENRRAFLKLRRQQQIERELNGY+EWI KAEEV+LAE++ + E++ P D
Sbjct: 360 SGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDG 419
Query: 415 VLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFF 474
L+R KKS+ DL++ EE ED+ AD+ +VGSPFARAS+KS K E+S++F +KE+ RF+
Sbjct: 420 ALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFY 479
Query: 475 IRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMY 534
IRRMVK Q+FYW VL +VALNTLCVA+VHYNQP L+ LY+AEF+FLGLF++EM +KMY
Sbjct: 480 IRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 539
Query: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
GLG R YF SSFNCFD GVI+GS+FEV+WA IKPG+SFGISVLRALRLLRIFKVTKYW+S
Sbjct: 540 GLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWAS 599
Query: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF + TP TNFDTFPAAI+
Sbjct: 600 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIM 659
Query: 655 TVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLAN 714
TVFQILTGEDWN VMY GI+SQGGV GM S YFIVLTLFGNYTLLNVFLAIAVDNLAN
Sbjct: 660 TVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLAN 719
Query: 715 AQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQ--NSAKARSVWEQRA 772
AQELTKDE+E EEAANQKLALQKAKEVAEVSP+SAAN+SIA ++Q N A+SVWEQR
Sbjct: 720 AQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRT 779
Query: 773 SQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGG 832
S++R QNL AS EALY+EMDP+ER + A TRHLRPDMKTHLDRPLVV+ +
Sbjct: 780 SEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKS 839
Query: 833 KARPEAAEAPEGV----DPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRP 888
+A + G D R+ R+ D+ + P+ A P A S E E P
Sbjct: 840 RAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYG 899
Query: 889 HRS--HSKEAA----GPPEARSERGRGPGP-------EGGRRHHRRGSPEEAAEREPRRH 935
S H++E + G E +ERG+ P +GG R R GSP A+ E RRH
Sbjct: 900 RESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRH 959
Query: 936 RAHRHQDPSKECAGAKGERRARHRGGPR---AGPREAESGEEPARRHRARHKAQPAHEA- 991
RAHR P +E K ERRARHR G R G E E + RR R RH A +E
Sbjct: 960 RAHRR--PGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGD 1017
Query: 992 ---VEKETTEKEATEKE----------------------------AEIVEADKEKELRNH 1020
+KE + E + AE ++ K +L
Sbjct: 1018 ARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATA 1077
Query: 1021 QPREPHCDLETSG----------TVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMG-- 1068
+ PH L +G + GPM +P+ + P++A ++R G
Sbjct: 1078 ESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPA-----MATNPQNAASRRTPNNPGNP 1132
Query: 1069 SQPPDP---------------------------NTIVHIPVMLTGPLGEATVVPSGNVD- 1100
S P P +T V IP PL V + N +
Sbjct: 1133 SNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANP 1192
Query: 1101 --LESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILV 1158
L + E KKE E DD GP+P+ PYSSMF LS TN LRR CHYI+ +RYFE+ IL+
Sbjct: 1193 DPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILM 1252
Query: 1159 VIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDL 1218
VIA+SSIALAAEDPV+ ++PRNN L+Y DY+FTGVFTFEMVIKMIDLGL+LH GAYFRDL
Sbjct: 1253 VIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDL 1312
Query: 1219 WNILDFIVVSGALVAFAFSG-SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVN 1277
WNILDFIVVSGALVAFAF+G SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVN
Sbjct: 1313 WNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVN 1372
Query: 1278 SLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQ 1337
SLKNV NILIVYMLFMFIFAV+AVQLFKGKFF+CTDESKE E+DCRG+YL YEK EV+A+
Sbjct: 1373 SLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKAR 1432
Query: 1338 PRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYV 1397
R+WKKY+FHYDNVLWALLTLFTVSTGEGWP VLKHSVDAT+E QGPSPGYRME+SIFYV
Sbjct: 1433 DREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYV 1492
Query: 1398 VYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNR 1457
VYFVVFPFFFVNIFVALIIITFQEQGDK+M E SLEKNERACIDFAISAKPLTR+MPQN+
Sbjct: 1493 VYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNK 1552
Query: 1458 QSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSME 1517
QSFQY+ W FVVSPPFEY IMAMIALNT+VLMMKFY A YE L+ NIVFTS+FS+E
Sbjct: 1553 QSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLE 1612
Query: 1518 CVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIK 1577
CVLK++AFG+LNYFRDAWN+FDFVTVLGSITDILVTE NNFINLSFLRLFRAARLIK
Sbjct: 1613 CVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG--NNFINLSFLRLFRAARLIK 1670
Query: 1578 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD--------DD 1629
LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI +D D+
Sbjct: 1671 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDE 1730
Query: 1630 TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQAN--ATECGSDFAYFY 1687
I HNNFRTF QALMLLFRSATGEAWH IMLSCLS + CD+ + ECG++FAYFY
Sbjct: 1731 FQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFY 1790
Query: 1688 FVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYN 1747
FVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDE++RVWAEYDPAACGRI Y
Sbjct: 1791 FVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYK 1850
Query: 1748 DMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKL 1807
DM+ +L+ +SPPLGLGKKCP RVA KRL+RM++P++ +D TVHF STLMALIRTAL+IK+
Sbjct: 1851 DMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVA-DDNTVHFNSTLMALIRTALDIKI 1909
Query: 1808 APAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQN 1867
A G + Q DAELRKE+ +W NL QKTLDLLV PHK ++TVGK+YAA+MI ++Y+Q+
Sbjct: 1910 AKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQS 1969
Query: 1868 K-----TTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSN 1922
K R++ + P +M P P+ + ST L
Sbjct: 1970 KAKKLQAMREEQDRTPLMFQRMEP---------------PSPTQEGGPGQNALPSTQLDP 2014
Query: 1923 GGAIQNQESGIKESVSWGTQRTQDAPHEARP-PLERGHSTEIPVGRSGALAVDVQMQSIT 1981
GGA+ ESG+KES SW TQR Q+ + E+G T++P S + V+M+ +
Sbjct: 2015 GGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMP--NSQPNSQSVEMREMG 2072
Query: 1982 RRG-PDGEPQPGLESQGRAASMPRLAAETQ------------PVTDASPMKRSISTLAQR 2028
R G D E +E QGRAASMPRL AE Q ++D SPMKRS S L
Sbjct: 2073 RDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLG-- 2130
Query: 2029 PRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPG 2088
P+ L + +R PP + HH RRRDR R+ E+ D+D + +
Sbjct: 2131 PKARRLDDYSLERVPPEENQRHH-----QRRRDRSHRASERSLGRYTDVDTGLGTDLSMT 2185
Query: 2089 LPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFY----SCDRFGGREPPKPKPS 2144
G+ P+ +ER QERGR ++R+ + DR+ P +
Sbjct: 2186 TQSGDLPS-----KERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRAR 2240
Query: 2145 LSSH--PTSPTAGQEPGPHPQ 2163
SP+ G+E H Q
Sbjct: 2241 ARDQRWSRSPSEGREHMAHRQ 2261
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 2285 bits (5921), Expect = 0.0
Identities = 1329/2412 (55%), Positives = 1577/2412 (65%), Gaps = 269/2412 (11%)
Query: 1 MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYN 60
M RFG+ + R PG G+ G P P GQ YKQ+ AQRARTMALYN
Sbjct: 1 MARFGEAVVAR---PGSGDGDSDQSRNRQGTPVPAS---GQAAAYKQTKAQRARTMALYN 54
Query: 61 PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD 120
PIPV+QNCFTVNRSLF+F EDN+VRKYAK++ +WPPFEYMILATIIANCIVLALEQHLP+
Sbjct: 55 PIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPE 114
Query: 121 GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA 180
DKTPMS RL+ TEPYFIGIFCFEAGIKI+ALGF+FHKGSYLRNGWNVMDF+VVL+GILA
Sbjct: 115 DDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILA 174
Query: 181 TAGTDF----DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236
TAGT F DLRTLRAVRVLRPLKLVSGIPSLQ+VLKSIMKAMVPLLQIGLLLFFAILM
Sbjct: 175 TAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILM 234
Query: 237 FAIIGLEFYMGKFHKACFPNSTDAEPVGD--FPCGKEAPARLCEGDTECREYWPGPNFGI 294
FAIIGLEFY GK H+ACF N++ D PCG + C EC++ W GPN GI
Sbjct: 235 FAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPAGYECKD-WIGPNDGI 289
Query: 295 TNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGV 354
T FDNILFA+LTVFQCITMEGWT +LYNTNDA G TWNWLYFIPLIIIGSFF+LNLVLGV
Sbjct: 290 TQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGV 349
Query: 355 LSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLD 414
LSGEFAKERERVENRRAF+KLRRQQQIERELNGY WI KAEEVMLAEE++NA S L+
Sbjct: 350 LSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGT-SALE 408
Query: 415 VLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFF 474
VL+RA K+SR + + + ++ D+ +VG+P ARAS+KS K + SYFR KE++ R
Sbjct: 409 VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
Query: 475 IRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMY 534
IR MVK+Q FYW+VL +VALNT CVA+VH+NQP+ LT LY+AEF+FLGLFL EMSLKMY
Sbjct: 469 IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
Query: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
G+GPR YF SSFNCFDFGV VGS+FEVVWA +PG+SFGISVLRALRLLRIFK+TKYW+S
Sbjct: 529 GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWAS 588
Query: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
LRNLVVSL++SMKSIISLLFLLFLFIVVFALLGMQLFGG+FNF D TP+ NFDTFPAAI+
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 655 TVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLAN 714
TVFQILTGEDWN VMY+GI SQGGVS GM+S+ YFIVLTLFGNYTLLNVFLAIAVDNLAN
Sbjct: 649 TVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLAN 708
Query: 715 AQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQ 774
AQELTKDE+E EEA NQK ALQKAK EVSPMSA N+ R + S+WE R+S
Sbjct: 709 AQELTKDEQEEEEAFNQKHALQKAK---EVSPMSAPNMPSIERDRRRRHHMSMWEPRSSH 765
Query: 775 LRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKA 834
LR + R M E+ +H++ + L+R + P+
Sbjct: 766 LRERRRR-------HHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPL---- 814
Query: 835 RPEAAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSK 894
++P H P+ + RA E G E+ R
Sbjct: 815 --------SSLNPLNAH---------PSLYRRPRA----IEGLALGLALEKFEEERI--- 850
Query: 895 EAAGPPEARSERGRGPGPEGGRRHHRRGSPEEAAEREP--RRHRAHRHQDPSKECAG--- 949
+R +G G + + +P +REP H + DP+++ AG
Sbjct: 851 -------SRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGE 903
Query: 950 --AKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAE 1007
E RARHR R +R R R + + + A + +E + EA
Sbjct: 904 AVVTFEDRARHRQSQRR-----------SRHRRVRTEGKESSSASRSRSASQERSLDEAM 952
Query: 1008 IVEADKEKELR-NHQPREPHC------DLETSGTVTVG--------------PMHTLPST 1046
E +K+ ELR NH +EP DL + ++ V P+ LP
Sbjct: 953 PTEGEKDHELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPL-VLPHP 1011
Query: 1047 CLQ------KVEEQPEDADNQR-------NVTRMGSQ-PPD-------------PNTIVH 1079
L+ E++PE + Q ++ R+ SQ PD +T V
Sbjct: 1012 ELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVT 1071
Query: 1080 IPVMLTGPLGEATVVP-SGNVDLESQAEGKKEVEADD----------VMRSGPRPIVPYS 1128
+ + PL ++TVV S D E+ + E+ D+ R + +VP+S
Sbjct: 1072 VAIPDVDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHS 1131
Query: 1129 SMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDY 1188
SMF S TN +RR CHYIV +RYFE+ IL+VIA SSIALAAEDPV T+S RN L+Y DY
Sbjct: 1132 SMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDY 1191
Query: 1189 IFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSG----SKGKDI 1244
+FTGVFTFEMVIKMID GL+L G+YFRDLWNILDF+VV GALVAFA + +KG+DI
Sbjct: 1192 VFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDI 1251
Query: 1245 NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVV SLKNV NILIVY LFMFIFAVIAVQLF
Sbjct: 1252 KTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLF 1311
Query: 1305 KGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTG 1364
KGKFFYCTD SK+ E++C G Y+D+EK ++E + R+WK+++FHYDN++WALLTLFTVSTG
Sbjct: 1312 KGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTG 1371
Query: 1365 EGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD 1424
EGWP VL+HSVD T E++GPS RME+SIFYVVYFVVFPFFFVNIFVALIIITFQEQGD
Sbjct: 1372 EGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD 1431
Query: 1425 KVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALN 1484
K+M ECSLEKNERACIDFAISAKPLTRYMPQNR +FQY+ W FVVSP FEY IMAMIALN
Sbjct: 1432 KMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALN 1491
Query: 1485 TVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVL 1544
TVVLMMK+Y AP YEL LK LNI FT +FS+ECVLK+IAFG LNYFRD WN+FDF+TV+
Sbjct: 1492 TVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVI 1551
Query: 1545 GSITDILVTE--IAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1602
GSIT+I++T+ + T+ F N+SFL+LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV
Sbjct: 1552 GSITEIILTDSKLVNTSGF-NMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
Query: 1603 CLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIML 1662
CLLIAMLFFIYAIIGMQVFGNI LD+++ INRHNNFR+F +LMLLFRSATGEAW EIML
Sbjct: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
Query: 1663 SCLSNQACDEQANA-------TECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLT 1715
SCL + C+ A CG+D AY YFVSFIF CSFLMLNLFVAVIMDNFEYLT
Sbjct: 1671 SCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLT 1730
Query: 1716 RDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRL 1775
RDSSILGPHHLDEF+RVWAEYD AACGRI Y +M+EML MSPPLGLGK+CP++VAYKRL
Sbjct: 1731 RDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRL 1790
Query: 1776 VRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQK 1835
V MNMP++ EDMTVHFTSTLMALIRTAL+IK+A G + Q D+EL+KE +W +L QK
Sbjct: 1791 VLMNMPVA-EDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQK 1849
Query: 1836 TLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKA 1895
LDLLVP K ++TVGK+YAA+MI D+YKQ+K + + Q L + +F ++
Sbjct: 1850 MLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQ-----LEEQKNAPMFQRMEP 1904
Query: 1896 TLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEA-RPP 1954
+ + A +L+Q + L SG S QD A P
Sbjct: 1905 SSLPQEIIANAKALPYLQQDPVSGL----------SGRSGYPSMSPLSPQDIFQLACMDP 1954
Query: 1955 LERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTD 2014
+ G E QS+ P S R+ S R +
Sbjct: 1955 ADDGQFQE--------------RQSLVVTDP--------SSMRRSFSTIRDKRSNSSWLE 1992
Query: 2015 ASPMKRSI-STLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSL 2073
M+RS +T R R H S + HR R + RS E+ L
Sbjct: 1993 EFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGR--ERGRSKERKHLL 2050
Query: 2074 SADMDGAPSSAVG-------PGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQR 2126
S D+ S G P P+ R + RQ G E PS S + R
Sbjct: 2051 SPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPR 2110
Query: 2127 FYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGG 2186
R PPKP+P LS AG P GS GSPL S + S
Sbjct: 2111 --RSRRQLPPVPPKPRPLLSYSSLIRHAG---SISPPADGSEEGSPLTSQALES-----N 2160
Query: 2187 RRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQ 2246
L ++ +P P ++ ++SP
Sbjct: 2161 NACLTESSNSPHPQ---QSQHASP------------------------------------ 2181
Query: 2247 PLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHP 2306
R S+PYL DS AS E+TLTFE AVAT+ GR S+ + P
Sbjct: 2182 -----QRYISEPYLALHEDSHAS-DCGEEETLTFEAAVATSLGR-------SNTIGSAPP 2228
Query: 2307 LR---RVPNGYH 2315
LR ++PNG++
Sbjct: 2229 LRHSWQMPNGHY 2240
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 773 bits (1997), Expect = 0.0
Identities = 430/936 (45%), Positives = 590/936 (63%), Gaps = 63/936 (6%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L DY+FT +FT E+++KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI--AETNNFINLSFLRLFRAARLIK 1577
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F RLFR RL+K
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVK 1327
Query: 1578 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNN 1637
LL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL+D T INR+NN
Sbjct: 1328 LLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNN 1387
Query: 1638 FRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----CGSDFAYFYFVS 1690
F+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE CGS FA FYF+S
Sbjct: 1388 FQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFIS 1447
Query: 1691 FIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMF 1750
F LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP A GRI + D+
Sbjct: 1448 FYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVV 1507
Query: 1751 EMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPA 1810
+L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RTAL IK
Sbjct: 1508 TLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALVRTALRIK---T 1563
Query: 1811 GTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTT 1870
Q + ELR I +W K LD +VPP DE+TVGK YA +I +++++ K
Sbjct: 1564 EGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKR 1623
Query: 1871 RDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
++ Q G SQ +SL L+ TL P + R
Sbjct: 1624 KE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1656
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 125 bits (315), Expect = 4e-28
Identities = 161/728 (22%), Positives = 302/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L A++VF +F E+ L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIIL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 125 bits (313), Expect = 6e-28
Identities = 75/264 (28%), Positives = 134/264 (50%), Gaps = 24/264 (9%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAI---KPGSSFGISVLRALRLLRIFKVTKYWSS 594
P+ YF ++N FD ++VGS+ ++ + + S I+ R R++R+ K+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPA 651
+R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T NF TFP
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQ 1393
Query: 652 AILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSSFYFIVLTLFGN 697
A+L +F+ TGE W +M + ES+ S F+ FYFI +
Sbjct: 1394 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1453
Query: 698 YTLLNVFLAIAVDNLANAQELTKD 721
+ ++N+F+A+ +DN LT+D
Sbjct: 1454 FLIINLFVAVIMDNF---DYLTRD 1474
Score = 118 bits (296), Expect = 6e-26
Identities = 94/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 68.9 bits (167), Expect = 5e-11
Identities = 64/290 (22%), Positives = 118/290 (40%), Gaps = 69/290 (23%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Y + WN D ++V+ I+ A T+ + + R RV+R +KL+S
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333
Query: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFP 267
++ +L + +K+ L + LL+ ++A+IG++ F K ++T+
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALNDTTEINRNN--- 1386
Query: 268 CGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILY------ 321
NF A+L +F+C T E W DI+
Sbjct: 1387 ----------------------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1418
Query: 322 ---------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
N+ + G+++ YFI ++ +F ++NL + V+ F
Sbjct: 1419 KCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 773 bits (1996), Expect = 0.0
Identities = 433/951 (45%), Positives = 592/951 (62%), Gaps = 76/951 (7%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLL 1579
LK+IAF +YF DAWN FD + V+GSI DI +TE AE N+ I+++F RLFR RL+KLL
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVMRLVKLL 1327
Query: 1580 RQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFR 1639
+G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL+D T INR+NNF+
Sbjct: 1328 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQ 1387
Query: 1640 TFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----CGSDFAYFYFVSFI 1692
TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE CGS FA FYF+SF
Sbjct: 1388 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFY 1447
Query: 1693 FLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEM 1752
LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP A GRI + D+ +
Sbjct: 1448 MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTL 1507
Query: 1753 LKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIK------ 1806
L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RTAL IK
Sbjct: 1508 LRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALVRTALRIKTEEGPS 1566
Query: 1807 -----------LAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVY 1855
PAG + Q + ELR I +W K LD +VPP DE+TVGK Y
Sbjct: 1567 PSEAHQGAEDPFRPAGNLE-QANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFY 1625
Query: 1856 AALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
A +I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1626 ATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1673
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 125 bits (313), Expect = 6e-28
Identities = 75/262 (28%), Positives = 134/262 (51%), Gaps = 22/262 (8%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEV-VWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLR 596
P+ YF ++N FD ++VGS+ ++ + + S I+ R R++R+ K+ +R
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1334
Query: 597 NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPAAI 653
L+ + + S +++ + L+ + ++A++GMQ+F G+ D T NF TFP A+
Sbjct: 1335 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQAV 1393
Query: 654 LTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSSFYFIVLTLFGNYT 699
L +F+ TGE W +M + ES+ S F+ FYFI + +
Sbjct: 1394 LLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFL 1453
Query: 700 LLNVFLAIAVDNLANAQELTKD 721
++N+F+A+ +DN LT+D
Sbjct: 1454 IINLFVAVIMDNF---DYLTRD 1472
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 69.7 bits (169), Expect = 3e-11
Identities = 64/288 (22%), Positives = 117/288 (40%), Gaps = 67/288 (23%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD-------FDLRTLRAVRVLRPLKLVSGIPSL 209
Y + WN D ++V+ I+ A T+ + R RV+R +KL+S +
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVMRLVKLLSRGEGI 1333
Query: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
+ +L + +K+ L + LL+ ++A+IG++ F K ++T+
Sbjct: 1334 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALNDTTEINRNN----- 1384
Query: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILY-------- 321
NF A+L +F+C T E W DI+
Sbjct: 1385 --------------------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKC 1418
Query: 322 -------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
N+ + G+++ YFI ++ +F ++NL + V+ F
Sbjct: 1419 APESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1466
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 772 bits (1993), Expect = 0.0
Identities = 433/953 (45%), Positives = 594/953 (62%), Gaps = 78/953 (8%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L DY+FT +FT E+++KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI--AETNNFINLSFLRLFRAARLIK 1577
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F RLFR RL+K
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVK 1327
Query: 1578 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNN 1637
LL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL+D T INR+NN
Sbjct: 1328 LLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNN 1387
Query: 1638 FRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----CGSDFAYFYFVS 1690
F+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE CGS FA FYF+S
Sbjct: 1388 FQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFIS 1447
Query: 1691 FIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMF 1750
F LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP A GRI + D+
Sbjct: 1448 FYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVV 1507
Query: 1751 EMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIK---- 1806
+L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RTAL IK
Sbjct: 1508 TLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALVRTALRIKTEEG 1566
Query: 1807 -------------LAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGK 1853
PAG + Q + ELR I +W K LD +VPP DE+TVGK
Sbjct: 1567 PSPSEAHQGAEDPFRPAGNLE-QANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGK 1625
Query: 1854 VYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
YA +I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1626 FYATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1675
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 125 bits (315), Expect = 4e-28
Identities = 161/728 (22%), Positives = 302/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L A++VF +F E+ L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIIL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 125 bits (313), Expect = 6e-28
Identities = 75/264 (28%), Positives = 134/264 (50%), Gaps = 24/264 (9%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAI---KPGSSFGISVLRALRLLRIFKVTKYWSS 594
P+ YF ++N FD ++VGS+ ++ + + S I+ R R++R+ K+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPA 651
+R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T NF TFP
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQ 1393
Query: 652 AILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSSFYFIVLTLFGN 697
A+L +F+ TGE W +M + ES+ S F+ FYFI +
Sbjct: 1394 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1453
Query: 698 YTLLNVFLAIAVDNLANAQELTKD 721
+ ++N+F+A+ +DN LT+D
Sbjct: 1454 FLIINLFVAVIMDNF---DYLTRD 1474
Score = 118 bits (296), Expect = 6e-26
Identities = 94/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 68.9 bits (167), Expect = 5e-11
Identities = 64/290 (22%), Positives = 118/290 (40%), Gaps = 69/290 (23%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Y + WN D ++V+ I+ A T+ + + R RV+R +KL+S
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333
Query: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFP 267
++ +L + +K+ L + LL+ ++A+IG++ F K ++T+
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALNDTTEINRNN--- 1386
Query: 268 CGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILY------ 321
NF A+L +F+C T E W DI+
Sbjct: 1387 ----------------------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1418
Query: 322 ---------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
N+ + G+++ YFI ++ +F ++NL + V+ F
Sbjct: 1419 KCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 770 bits (1989), Expect = 0.0
Identities = 433/953 (45%), Positives = 593/953 (62%), Gaps = 78/953 (8%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI--AETNNFINLSFLRLFRAARLIK 1577
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F RLFR RL+K
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVK 1327
Query: 1578 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNN 1637
LL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL+D T INR+NN
Sbjct: 1328 LLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNN 1387
Query: 1638 FRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----CGSDFAYFYFVS 1690
F+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE CGS FA FYF+S
Sbjct: 1388 FQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFIS 1447
Query: 1691 FIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMF 1750
F LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP A GRI + D+
Sbjct: 1448 FYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVV 1507
Query: 1751 EMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIK---- 1806
+L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RTAL IK
Sbjct: 1508 TLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALVRTALRIKTEEG 1566
Query: 1807 -------------LAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGK 1853
PAG + Q + ELR I +W K LD +VPP DE+TVGK
Sbjct: 1567 PSPSEAHQGAEDPFRPAGNLE-QANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGK 1625
Query: 1854 VYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
YA +I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1626 FYATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1675
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 125 bits (313), Expect = 6e-28
Identities = 75/264 (28%), Positives = 134/264 (50%), Gaps = 24/264 (9%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAI---KPGSSFGISVLRALRLLRIFKVTKYWSS 594
P+ YF ++N FD ++VGS+ ++ + + S I+ R R++R+ K+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPA 651
+R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T NF TFP
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQ 1393
Query: 652 AILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSSFYFIVLTLFGN 697
A+L +F+ TGE W +M + ES+ S F+ FYFI +
Sbjct: 1394 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1453
Query: 698 YTLLNVFLAIAVDNLANAQELTKD 721
+ ++N+F+A+ +DN LT+D
Sbjct: 1454 FLIINLFVAVIMDNF---DYLTRD 1474
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 68.9 bits (167), Expect = 5e-11
Identities = 64/290 (22%), Positives = 118/290 (40%), Gaps = 69/290 (23%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Y + WN D ++V+ I+ A T+ + + R RV+R +KL+S
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333
Query: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFP 267
++ +L + +K+ L + LL+ ++A+IG++ F K ++T+
Sbjct: 1334 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALNDTTEINRNN--- 1386
Query: 268 CGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILY------ 321
NF A+L +F+C T E W DI+
Sbjct: 1387 ----------------------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1418
Query: 322 ---------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
N+ + G+++ YFI ++ +F ++NL + V+ F
Sbjct: 1419 KCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 769 bits (1986), Expect = 0.0
Identities = 430/947 (45%), Positives = 590/947 (62%), Gaps = 74/947 (7%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L DY+FT +FT E+++KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALM 1859
RTAL IK Q + ELR I +W K LD +VPP DE+TVGK YA +
Sbjct: 1567 RTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFL 1623
Query: 1860 IFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1624 IQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1667
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 125 bits (315), Expect = 4e-28
Identities = 161/728 (22%), Positives = 302/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L A++VF +F E+ L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIIL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 123 bits (309), Expect = 2e-27
Identities = 76/275 (27%), Positives = 134/275 (48%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF ++N FD ++VGS+ ++ + P S I+ R R++
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 118 bits (296), Expect = 6e-26
Identities = 94/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 64.7 bits (156), Expect = 1e-09
Identities = 64/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD--------------------LRTLRAVRV 196
Y + WN D ++V+ I+ A T+ + + R RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEINRNN-------------------------------NFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 769 bits (1986), Expect = 0.0
Identities = 430/947 (45%), Positives = 590/947 (62%), Gaps = 74/947 (7%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L DY+FT +FT E+++KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALM 1859
RTAL IK Q + ELR I +W K LD +VPP DE+TVGK YA +
Sbjct: 1567 RTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFL 1623
Query: 1860 IFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1624 IQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1667
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 125 bits (315), Expect = 4e-28
Identities = 161/728 (22%), Positives = 302/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L A++VF +F E+ L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIIL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 123 bits (309), Expect = 2e-27
Identities = 76/275 (27%), Positives = 134/275 (48%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF ++N FD ++VGS+ ++ + P S I+ R R++
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 118 bits (296), Expect = 6e-26
Identities = 94/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 64.7 bits (156), Expect = 1e-09
Identities = 64/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD--------------------LRTLRAVRV 196
Y + WN D ++V+ I+ A T+ + + R RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEINRNN-------------------------------NFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 769 bits (1986), Expect = 0.0
Identities = 429/947 (45%), Positives = 590/947 (62%), Gaps = 74/947 (7%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L DY+FT +FT E+++KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF YF D WNVFDF+ V+GSI D++++E AE N+ I+++F
Sbjct: 1268 LKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALM 1859
RTAL IK Q + ELR I +W K LD +VPP DE+TVGK YA +
Sbjct: 1567 RTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFL 1623
Query: 1860 IFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1624 IQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1667
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (320), Expect = 1e-28
Identities = 77/275 (28%), Positives = 135/275 (49%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF +N FDF +++GS+ +V+ + P S I+ R R++
Sbjct: 1275 PKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 125 bits (315), Expect = 4e-28
Identities = 161/728 (22%), Positives = 302/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L A++VF +F E+ L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIIL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 118 bits (296), Expect = 6e-26
Identities = 94/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 69.3 bits (168), Expect = 4e-11
Identities = 65/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGIL--------------------ATAGTDFDLRTLRAVRV 196
Y + WNV DF++V+ I+ A + + R RV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEIN-------------------------------RNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 14 [Homo sapiens]
Length = 2138
Score = 769 bits (1986), Expect = 0.0
Identities = 430/947 (45%), Positives = 590/947 (62%), Gaps = 74/947 (7%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L DY+FT +FT E+++KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALM 1859
RTAL IK Q + ELR I +W K LD +VPP DE+TVGK YA +
Sbjct: 1567 RTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFL 1623
Query: 1860 IFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1624 IQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1667
Score = 637 bits (1642), Expect = 0.0
Identities = 367/803 (45%), Positives = 483/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY DA G W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
+I GSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 VIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 219 bits (558), Expect = 2e-56
Identities = 186/717 (25%), Positives = 324/717 (45%), Gaps = 115/717 (16%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFV-NIFVALIIIT 1418
T EGW VL DA GY EL Y V V+F FFV N+ + ++
Sbjct: 358 QCITMEGWTDVLYWMQDAM--------GY--ELPWVYFVSLVIFGSFFVLNLVLGVLSGE 407
Query: 1419 FQEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP 1454
F ++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 408 FSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMP 467
Query: 1455 -------------------------------QNRQSFQYKTW---------TFVVSPPFE 1474
+++ S ++ W V S F
Sbjct: 468 TSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFY 527
Query: 1475 YFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDA 1534
+ ++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 1535 WNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQ 1594
+N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + +
Sbjct: 588 FNRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLN 646
Query: 1595 SFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATG 1654
S +++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TG
Sbjct: 647 SVRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTG 705
Query: 1655 EAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
E W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 706 EDWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 125 bits (315), Expect = 4e-28
Identities = 161/728 (22%), Positives = 302/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L A++VF +F E+ L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIIL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 123 bits (309), Expect = 2e-27
Identities = 76/275 (27%), Positives = 134/275 (48%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF ++N FD ++VGS+ ++ + P S I+ R R++
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 118 bits (296), Expect = 6e-26
Identities = 94/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 79.7 bits (195), Expect = 3e-14
Identities = 67/295 (22%), Positives = 126/295 (42%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ G + + YFVS + SF +LNL + V+ F
Sbjct: 365 WTDVLYWMQDAM-----------GYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 408
Score = 64.7 bits (156), Expect = 1e-09
Identities = 64/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD--------------------LRTLRAVRV 196
Y + WN D ++V+ I+ A T+ + + R RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEINRNN-------------------------------NFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 768 bits (1982), Expect = 0.0
Identities = 430/947 (45%), Positives = 589/947 (62%), Gaps = 74/947 (7%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALM 1859
RTAL IK Q + ELR I +W K LD +VPP DE+TVGK YA +
Sbjct: 1567 RTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFL 1623
Query: 1860 IFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1624 IQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1667
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 123 bits (309), Expect = 2e-27
Identities = 76/275 (27%), Positives = 134/275 (48%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF ++N FD ++VGS+ ++ + P S I+ R R++
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 64.7 bits (156), Expect = 1e-09
Identities = 64/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD--------------------LRTLRAVRV 196
Y + WN D ++V+ I+ A T+ + + R RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEINRNN-------------------------------NFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 768 bits (1982), Expect = 0.0
Identities = 429/947 (45%), Positives = 589/947 (62%), Gaps = 74/947 (7%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 761 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 816
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 817 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 865
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 866 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 909
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 910 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 969
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 970 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1026
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1027 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1086
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1087 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1146
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1147 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1205
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1206 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1264
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF YF D WNVFDF+ V+GSI D++++E AE N+ I+++F
Sbjct: 1265 LKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITF 1324
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1325 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1384
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1385 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1444
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1445 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1504
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1505 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1563
Query: 1800 RTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALM 1859
RTAL IK Q + ELR I +W K LD +VPP DE+TVGK YA +
Sbjct: 1564 RTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFL 1620
Query: 1860 IFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1621 IQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1664
Score = 650 bits (1676), Expect = 0.0
Identities = 369/800 (46%), Positives = 483/800 (60%), Gaps = 56/800 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAP-ARLCEGDTE 282
L I LL+ F I+++AIIGLE +MGK HK C+ A PC E R C+ T
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAAEDDPSPCALETGHGRQCQNGTV 328
Query: 283 CREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIII 342
C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ LIII
Sbjct: 329 CKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 388
Query: 343 GSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAE 402
GSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 448
Query: 403 EDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGKTES 460
ED +E+ P + + S + ++ E G D + C AR + + K++
Sbjct: 449 EDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISKSKF 499
Query: 461 SSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFV 520
S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA 559
Query: 521 FLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRAL 580
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVLR +
Sbjct: 560 LLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCV 619
Query: 581 RLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD- 639
RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF +
Sbjct: 620 RLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM 679
Query: 640 ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLFGNY 698
+T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L + GNY
Sbjct: 680 QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNY 739
Query: 699 TLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAR 757
LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E +
Sbjct: 740 ILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE----------------K 783
Query: 758 QQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPL 817
+Q + +V E + ++ L+++ A E P ++ + + K+ P
Sbjct: 784 KQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYPNPE 838
Query: 818 VV-ELGRDGARGPVGGKARP 836
E + PVG + RP
Sbjct: 839 TTGEEDEEEPEMPVGPRPRP 858
Score = 217 bits (553), Expect = 9e-56
Identities = 180/713 (25%), Positives = 323/713 (45%), Gaps = 110/713 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERD----C---RGQYLDYEKEEVEAQPRQWKKYDF-HYDNVLWALLTLFTVS 1362
C ++ D C G + V K+ ++DN +A+LT+F
Sbjct: 298 CYNQEGIAAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCI 357
Query: 1363 TGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQ 1422
T EGW VL DA + I++V ++ FF +N+ + ++ F ++
Sbjct: 358 TMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 408
Query: 1423 -------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP---- 1454
GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 REKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSET 468
Query: 1455 ---------------------------QNRQSFQYKTW---------TFVVSPPFEYFIM 1478
+++ S ++ W V S F + ++
Sbjct: 469 ESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVI 528
Query: 1479 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1538
++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +N F
Sbjct: 529 FLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRF 588
Query: 1539 DFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKA 1598
D V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S ++
Sbjct: 589 DCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRS 647
Query: 1599 LPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWH 1658
+ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE W+
Sbjct: 648 IASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 706
Query: 1659 EIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
+M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 SVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 752
Score = 127 bits (320), Expect = 1e-28
Identities = 77/275 (28%), Positives = 135/275 (49%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1212 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1271
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF +N FDF +++GS+ +V+ + P S I+ R R++
Sbjct: 1272 PKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1331
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1332 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1390
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1391 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1450
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1451 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1482
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 523 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 578
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 579 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 635
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 636 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 676
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 677 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 719
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 720 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 779
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 780 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 827
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 828 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 887
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 888 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 947
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 948 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1004
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1005 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1064
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1065 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1124
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1125 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1182
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1183 QRQCVEYA 1190
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 876 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 933
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 934 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 993
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 994 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1053
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1054 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1106
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1107 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1166
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1167 QEQGEQ-EYKNCELDKNQRQCVEYAL 1191
Score = 85.5 bits (210), Expect = 6e-16
Identities = 72/292 (24%), Positives = 130/292 (44%), Gaps = 63/292 (21%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-----------GNI 1624
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F I
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1625 ALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEAWHE 1659
A +DD S +H NF F A++ +F+ T E W +
Sbjct: 305 AAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTD 364
Query: 1660 IMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 VLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 405
Score = 69.3 bits (168), Expect = 4e-11
Identities = 65/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1218 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1270
Query: 157 HKGSYLRNGWNVMDFVVVLTGIL--------------------ATAGTDFDLRTLRAVRV 196
Y + WNV DF++V+ I+ A + + R RV
Sbjct: 1271 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1330
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1331 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1386
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1387 TTEIN-------------------------------RNNNFQTFPQAVLLLFRCATGEAW 1415
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1416 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1475
Query: 359 F 359
F
Sbjct: 1476 F 1476
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 768 bits (1982), Expect = 0.0
Identities = 429/947 (45%), Positives = 589/947 (62%), Gaps = 74/947 (7%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF YF D WNVFDF+ V+GSI D++++E AE N+ I+++F
Sbjct: 1268 LKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALM 1859
RTAL IK Q + ELR I +W K LD +VPP DE+TVGK YA +
Sbjct: 1567 RTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFL 1623
Query: 1860 IFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
I +++++ K ++ Q G SQ +SL L+ TL P + R
Sbjct: 1624 IQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1667
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (320), Expect = 1e-28
Identities = 77/275 (28%), Positives = 135/275 (49%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF +N FDF +++GS+ +V+ + P S I+ R R++
Sbjct: 1275 PKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 69.3 bits (168), Expect = 4e-11
Identities = 65/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGIL--------------------ATAGTDFDLRTLRAVRV 196
Y + WNV DF++V+ I+ A + + R RV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEIN-------------------------------RNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 9 [Homo sapiens]
Length = 2157
Score = 768 bits (1982), Expect = 0.0
Identities = 433/964 (44%), Positives = 594/964 (61%), Gaps = 89/964 (9%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L DY+FT +FT E+++KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIK-----------------LAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVP 1842
RTAL IK PAG + Q + ELR I +W K LD +VP
Sbjct: 1567 RTALRIKTEEGPSPSEAHQGAEDPFRPAGNLE-QANEELRAIIKKIWKRTSMKLLDQVVP 1625
Query: 1843 PHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQP 1902
P DE+TVGK YA +I +++++ K ++ Q G SQ +SL L+ TL P
Sbjct: 1626 PAGDDEVTVGKFYATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGP 1682
Query: 1903 AVLR 1906
+ R
Sbjct: 1683 EIRR 1686
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 125 bits (315), Expect = 4e-28
Identities = 161/728 (22%), Positives = 302/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L A++VF +F E+ L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIIL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 123 bits (309), Expect = 2e-27
Identities = 76/275 (27%), Positives = 134/275 (48%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF ++N FD ++VGS+ ++ + P S I+ R R++
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 118 bits (296), Expect = 6e-26
Identities = 94/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 64.7 bits (156), Expect = 1e-09
Identities = 64/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD--------------------LRTLRAVRV 196
Y + WN D ++V+ I+ A T+ + + R RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEINRNN-------------------------------NFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 8 [Homo sapiens]
Length = 2157
Score = 766 bits (1978), Expect = 0.0
Identities = 433/964 (44%), Positives = 593/964 (61%), Gaps = 89/964 (9%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF +YF DAWN FD + V+GSI DI +TE+ AE N+ I+++F
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIK-----------------LAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVP 1842
RTAL IK PAG + Q + ELR I +W K LD +VP
Sbjct: 1567 RTALRIKTEEGPSPSEAHQGAEDPFRPAGNLE-QANEELRAIIKKIWKRTSMKLLDQVVP 1625
Query: 1843 PHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQP 1902
P DE+TVGK YA +I +++++ K ++ Q G SQ +SL L+ TL P
Sbjct: 1626 PAGDDEVTVGKFYATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGP 1682
Query: 1903 AVLR 1906
+ R
Sbjct: 1683 EIRR 1686
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 123 bits (309), Expect = 2e-27
Identities = 76/275 (27%), Positives = 134/275 (48%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF ++N FD ++VGS+ ++ + P S I+ R R++
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 64.7 bits (156), Expect = 1e-09
Identities = 64/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD--------------------LRTLRAVRV 196
Y + WN D ++V+ I+ A T+ + + R RV
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEINRNN-------------------------------NFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 7 [Homo sapiens]
Length = 2157
Score = 766 bits (1978), Expect = 0.0
Identities = 432/964 (44%), Positives = 593/964 (61%), Gaps = 89/964 (9%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI-------------AETNNFINLSF 1566
LK+IAF YF D WNVFDF+ V+GSI D++++E AE N+ I+++F
Sbjct: 1268 LKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITF 1327
Query: 1567 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 1626
RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL
Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387
Query: 1627 DDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----C 1679
+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE C
Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447
Query: 1680 GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPA 1739
GS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP
Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1507
Query: 1740 ACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALI 1799
A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+
Sbjct: 1508 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALV 1566
Query: 1800 RTALEIK-----------------LAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVP 1842
RTAL IK PAG + Q + ELR I +W K LD +VP
Sbjct: 1567 RTALRIKTEEGPSPSEAHQGAEDPFRPAGNLE-QANEELRAIIKKIWKRTSMKLLDQVVP 1625
Query: 1843 PHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQP 1902
P DE+TVGK YA +I +++++ K ++ Q G SQ +SL L+ TL P
Sbjct: 1626 PAGDDEVTVGKFYATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGP 1682
Query: 1903 AVLR 1906
+ R
Sbjct: 1683 EIRR 1686
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (320), Expect = 1e-28
Identities = 77/275 (28%), Positives = 135/275 (49%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF +N FDF +++GS+ +V+ + P S I+ R R++
Sbjct: 1275 PKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1334
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1335 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1393
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1394 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1453
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 69.3 bits (168), Expect = 4e-11
Identities = 65/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGIL--------------------ATAGTDFDLRTLRAVRV 196
Y + WNV DF++V+ I+ A + + R RV
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1389
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1390 TTEIN-------------------------------RNNNFQTFPQAVLLLFRCATGEAW 1418
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1419 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 359 F 359
F
Sbjct: 1479 F 1479
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 765 bits (1976), Expect = 0.0
Identities = 415/908 (45%), Positives = 572/908 (62%), Gaps = 58/908 (6%)
Query: 1100 DLESQAEGKKEVEADDVMRSGPRP-----------IVPY---SSMFCLSPTNLLRRFCHY 1145
D+ E ++E E + + +GPRP I P S+ F LS TN +R CH
Sbjct: 822 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 881
Query: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDL 1205
++ F +ILV I LSS ALAAEDP+R+ S RN L Y DY FT +FT E+++KM
Sbjct: 882 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 941
Query: 1206 GLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRL 1265
G LH GA+ R+ +N+LD +VV +LV+F S I+ +K LRVLRVLRPL+ I R
Sbjct: 942 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA---ISVVKILRVLRVLRPLRAINRA 998
Query: 1266 PKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQ 1325
LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTDE+K +CRG
Sbjct: 999 KGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGL 1058
Query: 1326 YLDYEKEEVEA---QPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQ 1382
++ Y+ +V++ + R W+ DF++DNVL A++ LFTVST EGWP +L ++D+ E
Sbjct: 1059 FILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENI 1118
Query: 1383 GPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDF 1442
GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K C L+KN+R C+++
Sbjct: 1119 GPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY 1178
Query: 1443 AISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1502
A+ A+PL RY+P+N +QYK W V S PFEY + +I LNT+ L M+ Y+ +
Sbjct: 1179 ALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDA 1236
Query: 1503 LKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI--AETNN 1560
+ LN+VFT +F++E VLK+IAF YF DAWN FD + V+GSI D+ ++E +E +N
Sbjct: 1237 MDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESN 1296
Query: 1561 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1620
I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLIAMLFFIYA+IGMQ+
Sbjct: 1297 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQM 1356
Query: 1621 FGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANAT--- 1677
FG +A+ D+ INR+NNF+TF QA++LLFR ATGEAW EIML+CL + CD +++
Sbjct: 1357 FGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE 1416
Query: 1678 --ECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAE 1735
CGS+FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+W+E
Sbjct: 1417 EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE 1476
Query: 1736 YDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTL 1795
YDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL
Sbjct: 1477 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPL-NSDGTVMFNATL 1535
Query: 1796 MALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVY 1855
AL+RTAL+IK Q + ELR I +W K LD +VPP DE+TVGK Y
Sbjct: 1536 FALVRTALKIK---TEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFY 1592
Query: 1856 AALMIFDFYKQNKTTRDQ--------------MQQAPGGLSQMGPVSLFHPLKATLEQTQ 1901
A +I D++++ K ++Q +Q L +GP + + L+ +
Sbjct: 1593 ATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGP-EIRRAISCDLQDDE 1651
Query: 1902 PAVLRGARVFLRQKSSTSLSNGGAI----QNQESGIKESVSWGTQRTQDAPHEARPPLER 1957
P + R++ GA+ N + + T T H RP +
Sbjct: 1652 PEETK------REEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1705
Query: 1958 GHSTEIPV 1965
TE P+
Sbjct: 1706 ASDTEKPL 1713
Score = 625 bits (1612), Expect = e-178
Identities = 348/692 (50%), Positives = 448/692 (64%), Gaps = 35/692 (5%)
Query: 73 RSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD 132
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+ D + L+
Sbjct: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
Query: 133 TEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---------TAG 183
E F+ IF E +KIIA G + H +Y+RNGWN++DFV+V+ G+ + T G
Sbjct: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
Query: 184 TD--------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIL 235
+ FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPLL I LL+ F I+
Sbjct: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
Query: 236 MFAIIGLEFYMGKFHKACFPNSTDAEPVGD-FPCGKEAPARLCEGD-TECREYWPGPNFG 293
++AIIGLE ++GK HK CF +D D PC R C + TECR W GPN G
Sbjct: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
Query: 294 ITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLG 353
ITNFDN FA+LTVFQCITMEGWTD+LY NDA G W+YF+ L+I GSFF+LNLVLG
Sbjct: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403
Query: 354 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPL 413
VLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++ E+ EE
Sbjct: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRN 463
Query: 414 DVLKRAATKKSRNDLIHAEEGEDR--FADLCAVGSPFARASLKSGKTESSSYFRRKEKMF 471
+ + T+ + + E GE+R LC S K++ S +RR +
Sbjct: 464 TSMPTSETESVNTENVSGE-GENRGCCGSLCQAIS----------KSKLSRRWRRWNRFN 512
Query: 472 RFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSL 531
R R VK+ +FYW+V+ +V LNTL ++ HYNQP LT A V L LF EM +
Sbjct: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLV 572
Query: 532 KMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKY 591
KMY LG ++YF S FN FD V+ G + E + ++ S GISV R +RLLRIFKVT++
Sbjct: 573 KMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRH 632
Query: 592 WSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD-ETPTTNFDTFP 650
W+SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNF + +T + FD FP
Sbjct: 633 WTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFP 692
Query: 651 AAILTVFQILTGEDWNAVMYHGIESQGG-VSKGMFSSFYFIVLTLFGNYTLLNVFLAIAV 709
A+LTVFQILTGEDWNAVMY GI + GG S GM YFI+L + GNY LLNVFLAIAV
Sbjct: 693 QALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAV 752
Query: 710 DNLANAQEL-TKDEEEMEEAANQKLALQKAKE 740
DNLA+A+ L T +EE EE +K+A +++ E
Sbjct: 753 DNLADAESLNTAQKEEAEEKERKKIARKESLE 784
Score = 221 bits (562), Expect = 9e-57
Identities = 180/706 (25%), Positives = 325/706 (46%), Gaps = 106/706 (15%)
Query: 1092 TVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRY 1151
T+ S + S ++ K++ A + P ++FCLS N +RR C IV +
Sbjct: 68 TMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKP 127
Query: 1152 FEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIKMIDLGLLL 1209
F++ IL+ I + +ALA P D N+ L+ ++Y F +FT E +K+I GLLL
Sbjct: 128 FDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLL 187
Query: 1210 HPGAYFRDLWNILDFIVVSGALVAFAF----------SGSKGKDIN-TIKSLRVLRVLRP 1258
HP AY R+ WN+LDF++V L + + S GK +K+LR RVLRP
Sbjct: 188 HPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRP 247
Query: 1259 LKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF---YCTDES 1315
L+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK + D
Sbjct: 248 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSD 307
Query: 1316 KELERDCRGQYLDYEKEEVEAQPRQWKK-------YDFHYDNVLWALLTLFTVSTGEGWP 1368
E D + A + + ++DN +A+LT+F T EGW
Sbjct: 308 IVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWT 367
Query: 1369 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ----- 1422
VL DA EL Y V V+F FFV N+ + ++ F ++
Sbjct: 368 DVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 417
Query: 1423 --GD--KVMSECSLEKNERACIDFAISAK------------------------------- 1447
GD K+ + LE++ + +D+ A+
Sbjct: 418 ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTE 477
Query: 1448 -------------PLTRYMPQNRQSFQYKTW---------TFVVSPPFEYFIMAMIALNT 1485
L + + +++ S +++ W V S F + ++ ++ LNT
Sbjct: 478 NVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNT 537
Query: 1486 VVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLG 1545
+ + + Y+ P + N V ++F+ E ++K+ + G+ YF +N FD V G
Sbjct: 538 LTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCG 597
Query: 1546 SITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1605
IT+ ++ E+ E + + +S R R R+ K+ R ++ L+ + + S K++ + LL
Sbjct: 598 GITETILVEL-EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLL 656
Query: 1606 IAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
+ + I++++GMQ+FG D+T R + F F QAL+ +F+ TGE W+ +M +
Sbjct: 657 LFLFIIIFSLLGMQLFGGKFNFDETQTKR-STFDNFPQALLTVFQILTGEDWNAVMYDGI 715
Query: 1666 SNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
+ C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 716 MAYGGPSSSGMIVC------IYFI-ILFICGNYILLNVFLAIAVDN 754
Score = 132 bits (333), Expect = 3e-30
Identities = 151/709 (21%), Positives = 299/709 (42%), Gaps = 121/709 (17%)
Query: 97 FEYMILATIIANCIVLALEQH-LPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
F ++++ + N + ++ E + PD +++ D + +F E +K+ +LG
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDW----LTQIQDIANKVLLALFTCEMLVKMYSLGLQ 580
Query: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT------LRAVRVLRPLKLVSGIPSL 209
+Y + +N D VV GI T + ++ + R VR+LR K+ SL
Sbjct: 581 ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 636
Query: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
++ S++ +M + + LLLF I++F+++G++ + GKF+
Sbjct: 637 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------ 678
Query: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
+T+ + + FDN A+LTVFQ +T E W ++Y+ A G
Sbjct: 679 ---------DETQTKR---------STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
Query: 330 TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK-------ERERVENRRAFLKLRR 377
+ +YFI L I G++ +LN+ L + A ++E E + K+ R
Sbjct: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKER-KKIAR 779
Query: 378 QQQIERELNGYLE--WIFKAEEVMLA----EEDRNAEEKSPLDVLKRAATKKSRNDLIHA 431
++ +E + N E I ++ + EED + + P DV ++ D
Sbjct: 780 KESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEV 839
Query: 432 EEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCV 491
G R + + A + G S+ + K R +++ F ++L
Sbjct: 840 PAGP-RPRRISELNMKEKIAPIPEG---SAFFILSKTNPIRVGCHKLINHHIFTNLILVF 895
Query: 492 VALNTLCVAMVHYNQPRRLTTTLY-FAEFVFLGLFLTEMSLKMYGLGP----RSYFRSSF 546
+ L++ +A + T+ + ++ F +F E+ LKM G ++ R+ F
Sbjct: 896 IMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF 955
Query: 547 NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSM 606
N D ++VG +V I+ + + +LR LR+LR + L+++V + ++
Sbjct: 956 NLLDM-LVVG--VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1012
Query: 607 KSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDETPTT--------------------- 644
++I +++ + L +FA +G+QLF G+F DE +
Sbjct: 1013 RTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVV 1072
Query: 645 ----------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS-----SFYF 689
NFD +A++ +F + T E W A++Y I+S G +++ S +F
Sbjct: 1073 RERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFF 1132
Query: 690 IVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKA 738
I+ + + ++N+F+ + E K+ + E NQ+ ++ A
Sbjct: 1133 IIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELDKNQRQCVEYA 1179
Score = 125 bits (313), Expect = 6e-28
Identities = 73/277 (26%), Positives = 140/277 (50%), Gaps = 24/277 (8%)
Query: 463 YFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFL 522
Y + ++F+ +V + F +++ ++ LNTLC+AM HY Q + + VF
Sbjct: 1188 YIPKNPYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1245
Query: 523 GLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAI---KPGSSFGISVLRA 579
G+F EM LK+ P+ YF ++N FD +++GS+ +V + + + I+ R
Sbjct: 1246 GVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRL 1305
Query: 580 LRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD 639
R++R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ +D
Sbjct: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAMRD 1364
Query: 640 ETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-----ESQGGVSKG-------MF 684
NF TFP A+L +F+ TGE W +M + + + + G F
Sbjct: 1365 NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNF 1424
Query: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
+ YFI + + ++N+F+A+ +DN LT+D
Sbjct: 1425 AIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1458
Score = 108 bits (271), Expect = 5e-23
Identities = 87/325 (26%), Positives = 154/325 (47%), Gaps = 22/325 (6%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+ S+ N +R ++ F +IL I+ + LA E P + + L
Sbjct: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ G HKG++ RN +N++D +VV +++ + ++
Sbjct: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 982
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GKF+
Sbjct: 983 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1042
Query: 251 KACFPNSTDAEPV-GDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQ 309
+ ++ E G F K+ + W +F NFDN+L A++ +F
Sbjct: 1043 RCTDEAKSNPEECRGLFILYKDGDV---DSPVVRERIWQNSDF---NFDNVLSAMMALFT 1096
Query: 310 CITMEGWTDILYNTNDAAGNTWNWLY---------FIPLIIIGSFFMLNLVLGVLSGEFA 360
T EGW +LY D+ G +Y FI III +FFM+N+ +G + F
Sbjct: 1097 VSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ 1156
Query: 361 KERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1157 EQGEK-EYKNCELDKNQRQCVEYAL 1180
Score = 82.0 bits (201), Expect = 6e-15
Identities = 71/294 (24%), Positives = 128/294 (43%), Gaps = 65/294 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PF+ FI+ I N V L + D L+ + F +F++E LKIIA+G+L
Sbjct: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF----------LRLFRAAR 1574
Y R+ WN+ DFV V+ + +++ ++ + N S LR FR R
Sbjct: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Query: 1575 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------G 1622
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
Query: 1623 NIALDDDTSINRHN-------------------------NFRTFLQALMLLFRSATGEAW 1657
+I ++D + + NF F A++ +F+ T E W
Sbjct: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
Query: 1658 HEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
+++ N A G + + YFVS + SF +LNL + V+ F
Sbjct: 367 TDVLY--WMNDAM---------GFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
Score = 76.6 bits (187), Expect = 3e-13
Identities = 66/289 (22%), Positives = 122/289 (42%), Gaps = 67/289 (23%)
Query: 96 PFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
PFEYM+ I+ N + LA++ + ++ +D F G+F E +K+IA
Sbjct: 1206 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1258
Query: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGI 206
F Y + WN D ++V+ I+ A ++ D + R RV+R +KL+S
Sbjct: 1259 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRG 1318
Query: 207 PSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDF 266
++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 1319 EGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF--------------------- 1357
Query: 267 PCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL------ 320
GK A + + + R NF A+L +F+C T E W +I+
Sbjct: 1358 --GKVA---MRDNNQINRN---------NNFQTFPQAVLLLFRCATGEAWQEIMLACLPG 1403
Query: 321 --------YNTND--AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
YN + G+ + +YFI ++ +F ++NL + V+ F
Sbjct: 1404 KLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 10 [Homo sapiens]
Length = 2155
Score = 763 bits (1969), Expect = 0.0
Identities = 429/964 (44%), Positives = 590/964 (61%), Gaps = 91/964 (9%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L DY+FT +FT E+++KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI------------------------ 1555
LK+IAF YF D WNVFDF+ V+GSI D++++E
Sbjct: 1268 LKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIA 1327
Query: 1556 ------AETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1609
AE N+ I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI ML
Sbjct: 1328 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1387
Query: 1610 FFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQA 1669
FFIYA+IGMQVFG IAL+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+ +
Sbjct: 1388 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1447
Query: 1670 C---DEQANATE----CGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILG 1722
C E +N+TE CGS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD SILG
Sbjct: 1448 CAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG 1507
Query: 1723 PHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPI 1782
PHHLDEF R+WAEYDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNMP+
Sbjct: 1508 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1567
Query: 1783 SNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVP 1842
N D TV F +TL AL+RTAL IK Q + ELR I +W K LD +VP
Sbjct: 1568 -NSDGTVMFNATLFALVRTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVP 1623
Query: 1843 PHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQP 1902
P DE+TVGK YA +I +++++ K ++ Q G SQ +SL L+ TL P
Sbjct: 1624 PAGDDEVTVGKFYATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHDIGP 1680
Query: 1903 AVLR 1906
+ R
Sbjct: 1681 EIRR 1684
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 125 bits (315), Expect = 4e-28
Identities = 161/728 (22%), Positives = 302/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L A++VF +F E+ L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIIL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 119 bits (298), Expect = 3e-26
Identities = 80/292 (27%), Positives = 138/292 (47%), Gaps = 52/292 (17%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVV-----------W----AAIKPGSSFGISV------ 576
P+ YF +N FDF +++GS+ +V+ W A I GS I++
Sbjct: 1275 PKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNA 1334
Query: 577 ----------LRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALL 626
R R++R+ K+ +R L+ + + S +++ + L+ + ++A++
Sbjct: 1335 EENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI 1394
Query: 627 GMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQ 676
GMQ+F G+ D T NF TFP A+L +F+ TGE W +M + ES+
Sbjct: 1395 GMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1453
Query: 677 GGVSK-------GMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
S F+ FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1502
Score = 118 bits (296), Expect = 6e-26
Identities = 94/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 62.8 bits (151), Expect = 4e-09
Identities = 65/318 (20%), Positives = 118/318 (37%), Gaps = 97/318 (30%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGIL------------------------------------- 179
Y + WNV DF++V+ I+
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNN 1333
Query: 180 ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAI 239
A + + R RV+R +KL+S ++ +L + +K+ L + LL+ ++A+
Sbjct: 1334 AEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAV 1393
Query: 240 IGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDN 299
IG++ F K ++T+ NF
Sbjct: 1394 IGMQV----FGKIALNDTTEIN-------------------------------RNNNFQT 1418
Query: 300 ILFAILTVFQCITMEGWTDILY---------------NTNDA---AGNTWNWLYFIPLII 341
A+L +F+C T E W DI+ N+ + G+++ YFI +
Sbjct: 1419 FPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYM 1478
Query: 342 IGSFFMLNLVLGVLSGEF 359
+ +F ++NL + V+ F
Sbjct: 1479 LCAFLIINLFVAVIMDNF 1496
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 761 bits (1965), Expect = 0.0
Identities = 466/1171 (39%), Positives = 646/1171 (55%), Gaps = 141/1171 (12%)
Query: 1100 DLESQAEGKKEVEADDVMRSGPRP-----------IVPY---SSMFCLSPTNLLRRFCHY 1145
D+ E ++E E + + +GPRP I P S+ F LS TN +R CH
Sbjct: 822 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 881
Query: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDL 1205
++ F +ILV I LSS ALAAEDP+R+ S RN L Y DY FT +FT E+++KM
Sbjct: 882 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 941
Query: 1206 GLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRL 1265
G LH GA+ R+ +N+LD +VV +LV+F S I+ +K LRVLRVLRPL+ I R
Sbjct: 942 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA---ISVVKILRVLRVLRPLRAINRA 998
Query: 1266 PKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQ 1325
LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTDE+K +CRG
Sbjct: 999 KGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGL 1058
Query: 1326 YLDYEKEEVEA---QPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQ 1382
++ Y+ +V++ + R W+ DF++DNVL A++ LFTVST EGWP +L ++D+ E
Sbjct: 1059 FILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENI 1118
Query: 1383 GPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDF 1442
GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K C L+KN+R C+++
Sbjct: 1119 GPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY 1178
Query: 1443 AISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1502
A+ A+PL RY+P+N +QYK W V S PFEY + +I LNT+ L M+ Y+ +
Sbjct: 1179 ALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDA 1236
Query: 1503 LKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI------- 1555
+ LN+VFT +F++E VLK+IAF YF DAWN FD + V+GSI D+ ++E
Sbjct: 1237 MDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESEN 1296
Query: 1556 ----------AETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1605
+E +N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LL
Sbjct: 1297 VPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1356
Query: 1606 IAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
IAMLFFIYA+IGMQ+FG +A+ D+ INR+NNF+TF QA++LLFR ATGEAW EIML+CL
Sbjct: 1357 IAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL 1416
Query: 1666 SNQACDEQANAT-----ECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI 1720
+ CD +++ CGS+FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SI
Sbjct: 1417 PGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI 1476
Query: 1721 LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNM 1780
LGPHHLDEF R+W+EYDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNM
Sbjct: 1477 LGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNM 1536
Query: 1781 PISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLL 1840
P+ N D TV F +TL AL+RTAL+IK Q + ELR I +W K LD +
Sbjct: 1537 PL-NSDGTVMFNATLFALVRTALKIK---TEGNLEQANEELRAVIKKIWKKTSMKLLDQV 1592
Query: 1841 VPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQ--------------MQQAPGGLSQMGP 1886
VPP DE+TVGK YA +I D++++ K ++Q +Q L +GP
Sbjct: 1593 VPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGP 1652
Query: 1887 VSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAI----QNQESGIKESVSWGTQ 1942
+ + L+ +P + R++ GA+ N + + T
Sbjct: 1653 -EIRRAISCDLQDDEPEETK------REEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTN 1705
Query: 1943 RTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASM 2002
T H RP + TE P+ +V + G + + A+M
Sbjct: 1706 TTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGK--QVPTSTNANLNNANM 1763
Query: 2003 PRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQAS-SHHHHHRCHRRRD 2061
+ A +P SI L H S DR P ++S ++ + R D
Sbjct: 1764 SKAAHGKRP---------SIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSD 1814
Query: 2062 RKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERE-----------RRQERGR 2110
L PT CR + E QE
Sbjct: 1815 SGDEQL---------------------------PTICREDPEIHGYFRDPHCLGEQEYFS 1847
Query: 2111 SQERRQPSSSSS-EKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVN 2169
S+E + SS + +Q + R+ GR +P H HPQG +
Sbjct: 1848 SEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPR-GYH------------HPQGFLEDD 1894
Query: 2170 GSPLLSTSGASTPGRGGRRQLPQTPLTPRPS 2200
SP+ S S RR LP TP + R S
Sbjct: 1895 DSPVCYDSRRSP----RRRLLPPTPASHRRS 1921
Score = 625 bits (1612), Expect = e-178
Identities = 348/692 (50%), Positives = 448/692 (64%), Gaps = 35/692 (5%)
Query: 73 RSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD 132
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+ D + L+
Sbjct: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
Query: 133 TEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---------TAG 183
E F+ IF E +KIIA G + H +Y+RNGWN++DFV+V+ G+ + T G
Sbjct: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
Query: 184 TD--------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIL 235
+ FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPLL I LL+ F I+
Sbjct: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
Query: 236 MFAIIGLEFYMGKFHKACFPNSTDAEPVGD-FPCGKEAPARLCEGD-TECREYWPGPNFG 293
++AIIGLE ++GK HK CF +D D PC R C + TECR W GPN G
Sbjct: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
Query: 294 ITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLG 353
ITNFDN FA+LTVFQCITMEGWTD+LY NDA G W+YF+ L+I GSFF+LNLVLG
Sbjct: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLG 403
Query: 354 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPL 413
VLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++ E+ EE
Sbjct: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRN 463
Query: 414 DVLKRAATKKSRNDLIHAEEGEDR--FADLCAVGSPFARASLKSGKTESSSYFRRKEKMF 471
+ + T+ + + E GE+R LC S K++ S +RR +
Sbjct: 464 TSMPTSETESVNTENVSGE-GENRGCCGSLCQAIS----------KSKLSRRWRRWNRFN 512
Query: 472 RFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSL 531
R R VK+ +FYW+V+ +V LNTL ++ HYNQP LT A V L LF EM +
Sbjct: 513 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLV 572
Query: 532 KMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKY 591
KMY LG ++YF S FN FD V+ G + E + ++ S GISV R +RLLRIFKVT++
Sbjct: 573 KMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRH 632
Query: 592 WSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD-ETPTTNFDTFP 650
W+SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNF + +T + FD FP
Sbjct: 633 WTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFP 692
Query: 651 AAILTVFQILTGEDWNAVMYHGIESQGG-VSKGMFSSFYFIVLTLFGNYTLLNVFLAIAV 709
A+LTVFQILTGEDWNAVMY GI + GG S GM YFI+L + GNY LLNVFLAIAV
Sbjct: 693 QALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAV 752
Query: 710 DNLANAQEL-TKDEEEMEEAANQKLALQKAKE 740
DNLA+A+ L T +EE EE +K+A +++ E
Sbjct: 753 DNLADAESLNTAQKEEAEEKERKKIARKESLE 784
Score = 221 bits (562), Expect = 9e-57
Identities = 180/706 (25%), Positives = 325/706 (46%), Gaps = 106/706 (15%)
Query: 1092 TVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRY 1151
T+ S + S ++ K++ A + P ++FCLS N +RR C IV +
Sbjct: 68 TMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKP 127
Query: 1152 FEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIKMIDLGLLL 1209
F++ IL+ I + +ALA P D N+ L+ ++Y F +FT E +K+I GLLL
Sbjct: 128 FDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLL 187
Query: 1210 HPGAYFRDLWNILDFIVVSGALVAFAF----------SGSKGKDIN-TIKSLRVLRVLRP 1258
HP AY R+ WN+LDF++V L + + S GK +K+LR RVLRP
Sbjct: 188 HPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRP 247
Query: 1259 LKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF---YCTDES 1315
L+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK + D
Sbjct: 248 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSD 307
Query: 1316 KELERDCRGQYLDYEKEEVEAQPRQWKK-------YDFHYDNVLWALLTLFTVSTGEGWP 1368
E D + A + + ++DN +A+LT+F T EGW
Sbjct: 308 IVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWT 367
Query: 1369 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ----- 1422
VL DA EL Y V V+F FFV N+ + ++ F ++
Sbjct: 368 DVLYWMNDA----------MGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 417
Query: 1423 --GD--KVMSECSLEKNERACIDFAISAK------------------------------- 1447
GD K+ + LE++ + +D+ A+
Sbjct: 418 ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTE 477
Query: 1448 -------------PLTRYMPQNRQSFQYKTW---------TFVVSPPFEYFIMAMIALNT 1485
L + + +++ S +++ W V S F + ++ ++ LNT
Sbjct: 478 NVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNT 537
Query: 1486 VVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLG 1545
+ + + Y+ P + N V ++F+ E ++K+ + G+ YF +N FD V G
Sbjct: 538 LTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCG 597
Query: 1546 SITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1605
IT+ ++ E+ E + + +S R R R+ K+ R ++ L+ + + S K++ + LL
Sbjct: 598 GITETILVEL-EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLL 656
Query: 1606 IAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
+ + I++++GMQ+FG D+T R + F F QAL+ +F+ TGE W+ +M +
Sbjct: 657 LFLFIIIFSLLGMQLFGGKFNFDETQTKR-STFDNFPQALLTVFQILTGEDWNAVMYDGI 715
Query: 1666 SNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
+ C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 716 MAYGGPSSSGMIVC------IYFI-ILFICGNYILLNVFLAIAVDN 754
Score = 132 bits (333), Expect = 3e-30
Identities = 151/709 (21%), Positives = 299/709 (42%), Gaps = 121/709 (17%)
Query: 97 FEYMILATIIANCIVLALEQH-LPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
F ++++ + N + ++ E + PD +++ D + +F E +K+ +LG
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDW----LTQIQDIANKVLLALFTCEMLVKMYSLGLQ 580
Query: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT------LRAVRVLRPLKLVSGIPSL 209
+Y + +N D VV GI T + ++ + R VR+LR K+ SL
Sbjct: 581 ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 636
Query: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
++ S++ +M + + LLLF I++F+++G++ + GKF+
Sbjct: 637 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------ 678
Query: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
+T+ + + FDN A+LTVFQ +T E W ++Y+ A G
Sbjct: 679 ---------DETQTKR---------STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG 720
Query: 330 TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK-------ERERVENRRAFLKLRR 377
+ +YFI L I G++ +LN+ L + A ++E E + K+ R
Sbjct: 721 PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKER-KKIAR 779
Query: 378 QQQIERELNGYLE--WIFKAEEVMLA----EEDRNAEEKSPLDVLKRAATKKSRNDLIHA 431
++ +E + N E I ++ + EED + + P DV ++ D
Sbjct: 780 KESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEV 839
Query: 432 EEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCV 491
G R + + A + G S+ + K R +++ F ++L
Sbjct: 840 PAGP-RPRRISELNMKEKIAPIPEG---SAFFILSKTNPIRVGCHKLINHHIFTNLILVF 895
Query: 492 VALNTLCVAMVHYNQPRRLTTTLY-FAEFVFLGLFLTEMSLKMYGLGP----RSYFRSSF 546
+ L++ +A + T+ + ++ F +F E+ LKM G ++ R+ F
Sbjct: 896 IMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF 955
Query: 547 NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSM 606
N D ++VG +V I+ + + +LR LR+LR + L+++V + ++
Sbjct: 956 NLLDM-LVVG--VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1012
Query: 607 KSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDETPTT--------------------- 644
++I +++ + L +FA +G+QLF G+F DE +
Sbjct: 1013 RTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVV 1072
Query: 645 ----------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS-----SFYF 689
NFD +A++ +F + T E W A++Y I+S G +++ S +F
Sbjct: 1073 RERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFF 1132
Query: 690 IVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKA 738
I+ + + ++N+F+ + E K+ + E NQ+ ++ A
Sbjct: 1133 IIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELDKNQRQCVEYA 1179
Score = 122 bits (306), Expect = 4e-27
Identities = 75/292 (25%), Positives = 140/292 (47%), Gaps = 39/292 (13%)
Query: 463 YFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFL 522
Y + ++F+ +V + F +++ ++ LNTLC+AM HY Q + + VF
Sbjct: 1188 YIPKNPYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1245
Query: 523 GLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSS----------- 571
G+F EM LK+ P+ YF ++N FD +++GS+ +V + P S
Sbjct: 1246 GVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1305
Query: 572 -------FGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFA 624
I+ R R++R+ K+ +R L+ + + S +++ + L+ + ++A
Sbjct: 1306 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1365
Query: 625 LLGMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-----ESQ 676
++GMQ+F G+ +D NF TFP A+L +F+ TGE W +M + + +
Sbjct: 1366 VIGMQMF-GKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPE 1424
Query: 677 GGVSKG-------MFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
+ G F+ YFI + + ++N+F+A+ +DN LT+D
Sbjct: 1425 SDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1473
Score = 108 bits (271), Expect = 5e-23
Identities = 87/325 (26%), Positives = 154/325 (47%), Gaps = 22/325 (6%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+ S+ N +R ++ F +IL I+ + LA E P + + L
Sbjct: 865 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ G HKG++ RN +N++D +VV +++ + ++
Sbjct: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 982
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GKF+
Sbjct: 983 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1042
Query: 251 KACFPNSTDAEPV-GDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQ 309
+ ++ E G F K+ + W +F NFDN+L A++ +F
Sbjct: 1043 RCTDEAKSNPEECRGLFILYKDGDV---DSPVVRERIWQNSDF---NFDNVLSAMMALFT 1096
Query: 310 CITMEGWTDILYNTNDAAGNTWNWLY---------FIPLIIIGSFFMLNLVLGVLSGEFA 360
T EGW +LY D+ G +Y FI III +FFM+N+ +G + F
Sbjct: 1097 VSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ 1156
Query: 361 KERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1157 EQGEK-EYKNCELDKNQRQCVEYAL 1180
Score = 82.0 bits (201), Expect = 6e-15
Identities = 71/294 (24%), Positives = 128/294 (43%), Gaps = 65/294 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PF+ FI+ I N V L + D L+ + F +F++E LKIIA+G+L
Sbjct: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF----------LRLFRAAR 1574
Y R+ WN+ DFV V+ + +++ ++ + N S LR FR R
Sbjct: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Query: 1575 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------G 1622
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
Query: 1623 NIALDDDTSINRHN-------------------------NFRTFLQALMLLFRSATGEAW 1657
+I ++D + + NF F A++ +F+ T E W
Sbjct: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
Query: 1658 HEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
+++ N A G + + YFVS + SF +LNL + V+ F
Sbjct: 367 TDVLY--WMNDAM---------GFELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 409
Score = 70.9 bits (172), Expect = 1e-11
Identities = 66/304 (21%), Positives = 122/304 (40%), Gaps = 82/304 (26%)
Query: 96 PFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
PFEYM+ I+ N + LA++ + ++ +D F G+F E +K+IA
Sbjct: 1206 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1258
Query: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFD------------------------LRTL 191
F Y + WN D ++V+ I+ A ++ D +
Sbjct: 1259 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFF 1318
Query: 192 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHK 251
R RV+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 1319 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------ 1372
Query: 252 ACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCI 311
GK A + + + R NF A+L +F+C
Sbjct: 1373 -----------------GKVA---MRDNNQINRN---------NNFQTFPQAVLLLFRCA 1403
Query: 312 TMEGWTDIL--------------YNTND--AAGNTWNWLYFIPLIIIGSFFMLNLVLGVL 355
T E W +I+ YN + G+ + +YFI ++ +F ++NL + V+
Sbjct: 1404 TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1463
Query: 356 SGEF 359
F
Sbjct: 1464 MDNF 1467
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 761 bits (1965), Expect = 0.0
Identities = 466/1171 (39%), Positives = 646/1171 (55%), Gaps = 141/1171 (12%)
Query: 1100 DLESQAEGKKEVEADDVMRSGPRP-----------IVPY---SSMFCLSPTNLLRRFCHY 1145
D+ E ++E E + + +GPRP I P S+ F LS TN +R CH
Sbjct: 842 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 901
Query: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDL 1205
++ F +ILV I LSS ALAAEDP+R+ S RN L Y DY FT +FT E+++KM
Sbjct: 902 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 961
Query: 1206 GLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRL 1265
G LH GA+ R+ +N+LD +VV +LV+F S I+ +K LRVLRVLRPL+ I R
Sbjct: 962 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA---ISVVKILRVLRVLRPLRAINRA 1018
Query: 1266 PKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQ 1325
LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTDE+K +CRG
Sbjct: 1019 KGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGL 1078
Query: 1326 YLDYEKEEVEA---QPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQ 1382
++ Y+ +V++ + R W+ DF++DNVL A++ LFTVST EGWP +L ++D+ E
Sbjct: 1079 FILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENI 1138
Query: 1383 GPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDF 1442
GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K C L+KN+R C+++
Sbjct: 1139 GPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY 1198
Query: 1443 AISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1502
A+ A+PL RY+P+N +QYK W V S PFEY + +I LNT+ L M+ Y+ +
Sbjct: 1199 ALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDA 1256
Query: 1503 LKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI------- 1555
+ LN+VFT +F++E VLK+IAF YF DAWN FD + V+GSI D+ ++E
Sbjct: 1257 MDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESEN 1316
Query: 1556 ----------AETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1605
+E +N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LL
Sbjct: 1317 VPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1376
Query: 1606 IAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
IAMLFFIYA+IGMQ+FG +A+ D+ INR+NNF+TF QA++LLFR ATGEAW EIML+CL
Sbjct: 1377 IAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL 1436
Query: 1666 SNQACDEQANAT-----ECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI 1720
+ CD +++ CGS+FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SI
Sbjct: 1437 PGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI 1496
Query: 1721 LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNM 1780
LGPHHLDEF R+W+EYDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNM
Sbjct: 1497 LGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNM 1556
Query: 1781 PISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLL 1840
P+ N D TV F +TL AL+RTAL+IK Q + ELR I +W K LD +
Sbjct: 1557 PL-NSDGTVMFNATLFALVRTALKIK---TEGNLEQANEELRAVIKKIWKKTSMKLLDQV 1612
Query: 1841 VPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQ--------------MQQAPGGLSQMGP 1886
VPP DE+TVGK YA +I D++++ K ++Q +Q L +GP
Sbjct: 1613 VPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGP 1672
Query: 1887 VSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAI----QNQESGIKESVSWGTQ 1942
+ + L+ +P + R++ GA+ N + + T
Sbjct: 1673 -EIRRAISCDLQDDEPEETK------REEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTN 1725
Query: 1943 RTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASM 2002
T H RP + TE P+ +V + G + + A+M
Sbjct: 1726 TTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGK--QVPTSTNANLNNANM 1783
Query: 2003 PRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQAS-SHHHHHRCHRRRD 2061
+ A +P SI L H S DR P ++S ++ + R D
Sbjct: 1784 SKAAHGKRP---------SIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSD 1834
Query: 2062 RKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERE-----------RRQERGR 2110
L PT CR + E QE
Sbjct: 1835 SGDEQL---------------------------PTICREDPEIHGYFRDPHCLGEQEYFS 1867
Query: 2111 SQERRQPSSSSS-EKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVN 2169
S+E + SS + +Q + R+ GR +P H HPQG +
Sbjct: 1868 SEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPR-GYH------------HPQGFLEDD 1914
Query: 2170 GSPLLSTSGASTPGRGGRRQLPQTPLTPRPS 2200
SP+ S S RR LP TP + R S
Sbjct: 1915 DSPVCYDSRRSP----RRRLLPPTPASHRRS 1941
Score = 628 bits (1620), Expect = e-179
Identities = 352/706 (49%), Positives = 455/706 (64%), Gaps = 43/706 (6%)
Query: 73 RSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD 132
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+ D + L+
Sbjct: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
Query: 133 TEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---------TAG 183
E F+ IF E +KIIA G + H +Y+RNGWN++DFV+V+ G+ + T G
Sbjct: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
Query: 184 TD--------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIL 235
+ FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPLL I LL+ F I+
Sbjct: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
Query: 236 MFAIIGLEFYMGKFHKACFPNSTDAEPVGD-FPCGKEAPARLCEGD-TECREYWPGPNFG 293
++AIIGLE ++GK HK CF +D D PC R C + TECR W GPN G
Sbjct: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
Query: 294 ITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLG 353
ITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ LII+GSFF+LNLVLG
Sbjct: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLG 403
Query: 354 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPL 413
VLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++ E+ EE
Sbjct: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRN 463
Query: 414 DVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFA----RASLKSG------------K 457
+ + T+ + + E GE+R GS + R + K+G K
Sbjct: 464 TSMPTSETESVNTENVSGE-GENRGC----CGSLWCWWRRRGAAKAGPSGCRRWGQAISK 518
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S +RR + R R VK+ +FYW+V+ +V LNTL ++ HYNQP LT A
Sbjct: 519 SKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIA 578
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
V L LF EM +KMY LG ++YF S FN FD V+ G + E + ++ S GISV
Sbjct: 579 NKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVF 638
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFKVT++W+SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 639 RCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 698
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGG-VSKGMFSSFYFIVLTLF 695
+ +T + FD FP A+LTVFQILTGEDWNAVMY GI + GG S GM YFI+L +
Sbjct: 699 DETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFIC 758
Query: 696 GNYTLLNVFLAIAVDNLANAQEL-TKDEEEMEEAANQKLALQKAKE 740
GNY LLNVFLAIAVDNLA+A+ L T +EE EE +K+A +++ E
Sbjct: 759 GNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLE 804
Score = 136 bits (342), Expect = 3e-31
Identities = 164/778 (21%), Positives = 322/778 (41%), Gaps = 145/778 (18%)
Query: 28 GAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKY 87
GA GP G + + + K +++R R +N ++ C R
Sbjct: 500 GAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFN----RRRC----------------RAA 539
Query: 88 AKRITEWPPFEYMILATIIANCIVLALEQH-LPDGDKTPMSERLDDTEPYFIGIFCFEAG 146
K +T F ++++ + N + ++ E + PD +++ D + +F E
Sbjct: 540 VKSVT----FYWLVIVLVFLNTLTISSEHYNQPDW----LTQIQDIANKVLLALFTCEML 591
Query: 147 IKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT------LRAVRVLRPL 200
+K+ +LG +Y + +N D VV GI T + ++ + R VR+LR
Sbjct: 592 VKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIF 647
Query: 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDA 260
K+ SL ++ S++ +M + + LLLF I++F+++G++ + GKF+
Sbjct: 648 KVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF--------- 698
Query: 261 EPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL 320
+T+ + + FDN A+LTVFQ +T E W ++
Sbjct: 699 ------------------DETQTKR---------STFDNFPQALLTVFQILTGEDWNAVM 731
Query: 321 YNTNDAAGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK-------ERERVEN 368
Y+ A G + +YFI L I G++ +LN+ L + A ++E E
Sbjct: 732 YDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 791
Query: 369 RRAFLKLRRQQQIERELNGYLE--WIFKAEEVMLA----EEDRNAEEKSPLDVLKRAATK 422
+ K+ R++ +E + N E I ++ + EED + + P DV +
Sbjct: 792 KER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEE 850
Query: 423 KSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQ 482
+ D G R + + A + G S+ + K R +++
Sbjct: 851 EEEEDEPEVPAGP-RPRRISELNMKEKIAPIPEG---SAFFILSKTNPIRVGCHKLINHH 906
Query: 483 SFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLY-FAEFVFLGLFLTEMSLKMYGLGP--- 538
F ++L + L++ +A + T+ + ++ F +F E+ LKM G
Sbjct: 907 IFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLH 966
Query: 539 -RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRN 597
++ R+ FN D ++VG +V I+ + + +LR LR+LR + L++
Sbjct: 967 KGAFCRNYFNLLDM-LVVG--VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKH 1023
Query: 598 LVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDETPTT------------ 644
+V + ++++I +++ + L +FA +G+QLF G+F DE +
Sbjct: 1024 VVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYK 1083
Query: 645 -------------------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS 685
NFD +A++ +F + T E W A++Y I+S G +++
Sbjct: 1084 DGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYN 1143
Query: 686 -----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKA 738
S +FI+ + + ++N+F+ + E K+ + E NQ+ ++ A
Sbjct: 1144 HRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELDKNQRQCVEYA 1199
Score = 135 bits (339), Expect = 6e-31
Identities = 100/366 (27%), Positives = 175/366 (47%), Gaps = 32/366 (8%)
Query: 1092 TVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRY 1151
T+ S + S ++ K++ A + P ++FCLS N +RR C IV +
Sbjct: 68 TMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKP 127
Query: 1152 FEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIKMIDLGLLL 1209
F++ IL+ I + +ALA P D N+ L+ ++Y F +FT E +K+I GLLL
Sbjct: 128 FDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLL 187
Query: 1210 HPGAYFRDLWNILDFIVVSGALVAFAF----------SGSKGKDIN-TIKSLRVLRVLRP 1258
HP AY R+ WN+LDF++V L + + S GK +K+LR RVLRP
Sbjct: 188 HPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRP 247
Query: 1259 LKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF---YCTDES 1315
L+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK + D
Sbjct: 248 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSD 307
Query: 1316 KELERDCRGQYLDYEKEEVEAQPRQWKK-------YDFHYDNVLWALLTLFTVSTGEGWP 1368
E D + A + + ++DN +A+LT+F T EGW
Sbjct: 308 IVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWT 367
Query: 1369 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMS 1428
VL DA G+ +++V ++ FF +N+ + ++ F ++ +K +
Sbjct: 368 DVLYWVNDAI--------GWEWPW-VYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKA 418
Query: 1429 ECSLEK 1434
+K
Sbjct: 419 RGDFQK 424
Score = 122 bits (306), Expect = 4e-27
Identities = 75/292 (25%), Positives = 140/292 (47%), Gaps = 39/292 (13%)
Query: 463 YFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFL 522
Y + ++F+ +V + F +++ ++ LNTLC+AM HY Q + + VF
Sbjct: 1208 YIPKNPYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1265
Query: 523 GLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSS----------- 571
G+F EM LK+ P+ YF ++N FD +++GS+ +V + P S
Sbjct: 1266 GVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1325
Query: 572 -------FGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFA 624
I+ R R++R+ K+ +R L+ + + S +++ + L+ + ++A
Sbjct: 1326 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1385
Query: 625 LLGMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-----ESQ 676
++GMQ+F G+ +D NF TFP A+L +F+ TGE W +M + + +
Sbjct: 1386 VIGMQMF-GKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPE 1444
Query: 677 GGVSKG-------MFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
+ G F+ YFI + + ++N+F+A+ +DN LT+D
Sbjct: 1445 SDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1493
Score = 112 bits (281), Expect = 3e-24
Identities = 72/269 (26%), Positives = 140/269 (52%), Gaps = 10/269 (3%)
Query: 1443 AISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1502
AIS L+R + + + + V S F + ++ ++ LNT+ + + Y+ P +
Sbjct: 515 AISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574
Query: 1503 LKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFI 1562
N V ++F+ E ++K+ + G+ YF +N FD V G IT+ ++ E+ E + +
Sbjct: 575 QDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVEL-EIMSPL 633
Query: 1563 NLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1622
+S R R R+ K+ R ++ L+ + + S K++ + LL+ + I++++GMQ+FG
Sbjct: 634 GISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFG 693
Query: 1623 NIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSD 1682
D+T R + F F QAL+ +F+ TGE W+ +M + + C
Sbjct: 694 GKFNFDETQTKR-STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVC--- 749
Query: 1683 FAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 750 ---IYFI-ILFICGNYILLNVFLAIAVDN 774
Score = 108 bits (271), Expect = 5e-23
Identities = 87/325 (26%), Positives = 154/325 (47%), Gaps = 22/325 (6%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+ S+ N +R ++ F +IL I+ + LA E P + + L
Sbjct: 885 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 942
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ G HKG++ RN +N++D +VV +++ + ++
Sbjct: 943 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 1002
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GKF+
Sbjct: 1003 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1062
Query: 251 KACFPNSTDAEPV-GDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQ 309
+ ++ E G F K+ + W +F NFDN+L A++ +F
Sbjct: 1063 RCTDEAKSNPEECRGLFILYKDGDV---DSPVVRERIWQNSDF---NFDNVLSAMMALFT 1116
Query: 310 CITMEGWTDILYNTNDAAGNTWNWLY---------FIPLIIIGSFFMLNLVLGVLSGEFA 360
T EGW +LY D+ G +Y FI III +FFM+N+ +G + F
Sbjct: 1117 VSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ 1176
Query: 361 KERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1177 EQGEK-EYKNCELDKNQRQCVEYAL 1200
Score = 93.6 bits (231), Expect = 2e-18
Identities = 71/277 (25%), Positives = 128/277 (46%), Gaps = 37/277 (13%)
Query: 1140 RRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMV 1199
RR C V F +++V++ L+++ +++E + D + + +FT EM+
Sbjct: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEML 591
Query: 1200 IKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPL 1259
+KM LGL AYF L+N D VV G + + I R +R+LR
Sbjct: 592 VKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIF 647
Query: 1260 KTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELE 1319
K + L + ++NS+K++ ++L++ LF+ IF+++ +QLF GKF + ++K
Sbjct: 648 KVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRST 707
Query: 1320 RDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATY 1379
+DN ALLT+F + TGE W V+ D
Sbjct: 708 ----------------------------FDNFPQALLTVFQILTGEDWNAVM---YDGIM 736
Query: 1380 EEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALII 1416
GPS M + I++++ F+ + +N+F+A+ +
Sbjct: 737 AYGGPSSS-GMIVCIYFIILFICGNYILLNVFLAIAV 772
Score = 83.6 bits (205), Expect = 2e-15
Identities = 73/294 (24%), Positives = 130/294 (44%), Gaps = 65/294 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PF+ FI+ I N V L + D L+ + F +F++E LKIIA+G+L
Sbjct: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF----------LRLFRAAR 1574
Y R+ WN+ DFV V+ + +++ ++ + N S LR FR R
Sbjct: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Query: 1575 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------G 1622
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
Query: 1623 NIALDDDTSINRHN-------------------------NFRTFLQALMLLFRSATGEAW 1657
+I ++D + + NF F A++ +F+ T E W
Sbjct: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
Query: 1658 HEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
+++ N A G ++ + YFVS I L SF +LNL + V+ F
Sbjct: 367 TDVLY--WVNDA---------IGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEF 409
Score = 70.9 bits (172), Expect = 1e-11
Identities = 66/304 (21%), Positives = 122/304 (40%), Gaps = 82/304 (26%)
Query: 96 PFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
PFEYM+ I+ N + LA++ + ++ +D F G+F E +K+IA
Sbjct: 1226 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1278
Query: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFD------------------------LRTL 191
F Y + WN D ++V+ I+ A ++ D +
Sbjct: 1279 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFF 1338
Query: 192 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHK 251
R RV+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 1339 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------ 1392
Query: 252 ACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCI 311
GK A + + + R NF A+L +F+C
Sbjct: 1393 -----------------GKVA---MRDNNQINRN---------NNFQTFPQAVLLLFRCA 1423
Query: 312 TMEGWTDIL--------------YNTND--AAGNTWNWLYFIPLIIIGSFFMLNLVLGVL 355
T E W +I+ YN + G+ + +YFI ++ +F ++NL + V+
Sbjct: 1424 TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1483
Query: 356 SGEF 359
F
Sbjct: 1484 MDNF 1487
>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
subunit [Homo sapiens]
Length = 1977
Score = 761 bits (1965), Expect = 0.0
Identities = 391/789 (49%), Positives = 534/789 (67%), Gaps = 26/789 (3%)
Query: 1102 ESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIA 1161
E + G E+ + V + PI S+ FCLS TN LR+ CH ++ F +ILV I
Sbjct: 823 EEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFII 882
Query: 1162 LSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNI 1221
LSS++LAAEDP+R S RN+ L Y DY FT +FT E+++KM G LH G++ R +N+
Sbjct: 883 LSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNM 942
Query: 1222 LDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKN 1281
LD +VVS +L++F S I+ +K LRVLRVLRPL+ I R LK V CV +++
Sbjct: 943 LDLLVVSVSLISFGIHSSA---ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 999
Query: 1282 VLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQP 1338
+ NI+IV L F+FA I VQLFKGKF+ CTDE+K ++C+G +L Y +V +
Sbjct: 1000 IGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRE 1059
Query: 1339 RQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVV 1398
R W DF++DNVL A++ LFTVST EGWP +L ++DA E+ GP YR+E+S+F++V
Sbjct: 1060 RLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIV 1119
Query: 1399 YFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQ 1458
Y ++ FF +NIFV +IITF+ QG++ C L+KN+R C+++A+ A+PL RY+P+N
Sbjct: 1120 YIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPH 1179
Query: 1459 SFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMEC 1518
QY+ W V S FEY + +I LNTV L M+ Y+ + + LN+VFT +F++E
Sbjct: 1180 --QYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEM 1237
Query: 1519 VLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI---------AETNNFINLSFLRL 1569
VLKIIAF +YF DAWN FD + V+GSI DI VTE+ +E ++ I+++F RL
Sbjct: 1238 VLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRL 1297
Query: 1570 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDD 1629
FR RL+KLL +G IR LLWTF++SF+ALPYV LLIAM+FFIYA+IGMQ+FG +AL D
Sbjct: 1298 FRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDG 1357
Query: 1630 TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQAN-----ATECGSDFA 1684
T INR+NNF+TF QA++LLFR ATGEAW EIML+ L CD +++ CGS+FA
Sbjct: 1358 TQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFA 1417
Query: 1685 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRI 1744
YF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+W+EYDP A GRI
Sbjct: 1418 IAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRI 1477
Query: 1745 SYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALE 1804
+ D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RT+L+
Sbjct: 1478 KHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPL-NSDGTVTFNATLFALVRTSLK 1536
Query: 1805 IKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFY 1864
IK Q + ELR I +W + QK LD ++PP +E+TVGK YA +I D++
Sbjct: 1537 IK---TEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYF 1593
Query: 1865 KQNKTTRDQ 1873
++ + +++
Sbjct: 1594 RKFRRRKEK 1602
Score = 603 bits (1554), Expect = e-172
Identities = 362/843 (42%), Positives = 476/843 (56%), Gaps = 67/843 (7%)
Query: 16 GGGERARGGGAGGAGGPGPG-GLQPGQRVLYKQSIA-------QRARTMALYNPIPVKQN 67
GG + GPGP GL PG + +S +R + + + V +
Sbjct: 6 GGKDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTVAVA-S 64
Query: 68 CFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMS 127
R+LF + N +R+ I EW PF+ +IL TI ANC+ L + P+ D +
Sbjct: 65 AQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTAN 124
Query: 128 ERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA------- 180
L+ E F+ IF E +KI+A G V H +Y+RNGWN++DF++V+ G+ +
Sbjct: 125 HNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGP 184
Query: 181 --------TAGTD--FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLL 230
T G FD++ LRA RVLRPL+LVSG+PSL +VL SIMKA+VPLL I LL+
Sbjct: 185 GRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLV 244
Query: 231 FFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGD-FPCGKEAPARLCE-GDTECREYWP 288
F I+++AIIGLE ++G+ HK C+ +D E D PC R C TECR WP
Sbjct: 245 LFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWP 304
Query: 289 GPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFML 348
GPN GITNFDN FA+LTVFQC+TMEGWTD+LY DA G W+YF+ L+I GSFF+L
Sbjct: 305 GPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVL 364
Query: 349 NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEV---------- 398
NLVLGVLSGEF+KERE+ + R F K R +QQ+E +L GYL+WI +AEE+
Sbjct: 365 NLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDN 424
Query: 399 --MLAEEDRNAEEKSPLDVLKRA---------ATKKSRNDLIHA-----------EEGED 436
+AEE R ++ R +T+ + + HA E D
Sbjct: 425 LGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGD 484
Query: 437 RFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNT 496
+ A+ S R K KT RR ++ R RR VK+ + YW VL +V LNT
Sbjct: 485 EDEEEGALAS-CTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNT 543
Query: 497 LCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVG 556
L +A H+ QP LT +A V L LF EM LK+YGLGP +Y S FN FD V+ G
Sbjct: 544 LTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCG 603
Query: 557 SVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLL 616
+ E + GISVLR +RLLRIFKVT++W+SL NLV SLLNSMKSI SLL LL
Sbjct: 604 GILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLL 663
Query: 617 FLFIVVFALLGMQLFGGQFNF-QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
FLFI++F+LLGMQLFGG+FNF Q T + FDTFP A+LTVFQILTGEDWN VMY GI +
Sbjct: 664 FLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMA 723
Query: 676 QGG-VSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLA 734
GG GM YFI+L + GNY LLNVFLAIAVDNLA+ T ++ E++ + L
Sbjct: 724 YGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEKDLP 783
Query: 735 LQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPE 794
+ V V AR++ + E+ + + A L E+ P+
Sbjct: 784 QENEGLVPGVEKEEEE----GARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPK 839
Query: 795 ERL 797
E++
Sbjct: 840 EKV 842
Score = 144 bits (362), Expect = 1e-33
Identities = 101/330 (30%), Positives = 169/330 (51%), Gaps = 34/330 (10%)
Query: 1129 SMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYL 1186
++FCL+ N LRR C IV + F+++IL+ I + +AL P D N+ L+ +
Sbjct: 71 ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130
Query: 1187 DYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINT 1246
+Y+F +FT E V+K++ GL+LHP AY R+ WN+LDFI+V L + G+ +
Sbjct: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
Query: 1247 -----------IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFI 1295
+K+LR RVLRPL+ + +P L V + ++ +L +L+I ++ + + I
Sbjct: 191 PHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIII 250
Query: 1296 FAVIAVQLFKGK-----FFYCTD-ESKELERDC----RGQYLDYEKEEVEAQPRQWKKYD 1345
+A+I ++LF G+ +F +D E++E C G+ + E +
Sbjct: 251 YAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGI 310
Query: 1346 FHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPF 1405
++DN +A+LT+F T EGW VL DA GY EL Y V V+F
Sbjct: 311 TNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAM--------GY--ELPWVYFVSLVIFGS 360
Query: 1406 FFV-NIFVALIIITFQEQGDKVMSECSLEK 1434
FFV N+ + ++ F ++ +K + +K
Sbjct: 361 FFVLNLVLGVLSGEFSKEREKAKARGDFQK 390
Score = 124 bits (312), Expect = 8e-28
Identities = 150/690 (21%), Positives = 280/690 (40%), Gaps = 128/690 (18%)
Query: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
+ V+R +R + + +L + N + +A E H G +++ + + +
Sbjct: 515 NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHH---GQPVWLTQIQEYANKVLLCL 571
Query: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILAT------AGTDFDLRTLRAV 194
F E +K+ LG +Y+ + +N D VV GIL T A + LR V
Sbjct: 572 FTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCV 627
Query: 195 RVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACF 254
R+LR K+ SL ++ S++ +M + + LLLF I++F+++G++ + GKF+
Sbjct: 628 RLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF--- 684
Query: 255 PNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITME 314
T + + FD A+LTVFQ +T E
Sbjct: 685 ------------------------DQTHTKR---------STFDTFPQALLTVFQILTGE 711
Query: 315 GWTDILYNTNDAAGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENR 369
W ++Y+ A G + +YFI L I G++ +LN+ L + A
Sbjct: 712 DWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKD 771
Query: 370 RAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLI 429
+ K ++ + +E G + + K EE E + EE+ +
Sbjct: 772 KGGEK-SNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEE--------------- 815
Query: 430 HAEEGEDRFADLCAVGSPFARASLKSGKT----ESSSYFRRKE-KMFRFFIRRMVKAQSF 484
EE E+ + A G + + K E S++F + R ++ F
Sbjct: 816 --EEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVF 873
Query: 485 YWVVLCVVALNTLCVAMVHYNQPRRLTT----TLYFAEFVFLGLFLTEMSLKMYGLGP-- 538
++L + L+++ +A P R + L + ++ F +F E+ LKM G
Sbjct: 874 TNLILVFIILSSVSLAA---EDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFL 930
Query: 539 --RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLR 596
S+ RS FN D V+ S+ I + + +LR LR+LR + L+
Sbjct: 931 HRGSFCRSWFNMLDLLVVSVSLISF---GIHSSAISVVKILRVLRVLRPLRAINRAKGLK 987
Query: 597 NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDETPTT----------- 644
++V + ++++I +++ + L +FA +G+QLF G+F DE T
Sbjct: 988 HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVY 1047
Query: 645 --------------------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMF 684
NFD +A++ +F + T E W A++Y I++ ++
Sbjct: 1048 PDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIY 1107
Query: 685 S-----SFYFIVLTLFGNYTLLNVFLAIAV 709
+ S +FIV + + ++N+F+ +
Sbjct: 1108 NYRVEISVFFIVYIIIIAFFMMNIFVGFVI 1137
Score = 124 bits (311), Expect = 1e-27
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 29/268 (10%)
Query: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGP 538
V + +F +++ ++ LNT+ +AM HY Q + VF GLF EM LK+ P
Sbjct: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246
Query: 539 RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFG----------ISVLRALRLLRIFKV 588
+ YF ++N FD ++VGS+ ++ + G G I+ R R++R+ K+
Sbjct: 1247 KHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKL 1306
Query: 589 TKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTN 645
+R L+ + + S +++ + L+ + ++A++GMQ+F G+ QD T N
Sbjct: 1307 LSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINRNNN 1365
Query: 646 FDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-----GMFSSFYFIVLT 693
F TFP A+L +F+ TGE W +M + ES G + F+ YFI
Sbjct: 1366 FQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFF 1425
Query: 694 LFGNYTLLNVFLAIAVDNLANAQELTKD 721
+ + ++N+F+A+ +DN LT+D
Sbjct: 1426 MLCAFLIINLFVAVIMDNF---DYLTRD 1450
Score = 108 bits (270), Expect = 6e-23
Identities = 102/370 (27%), Positives = 172/370 (46%), Gaps = 47/370 (12%)
Query: 33 GPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRIT 92
G GG++ Q V+ K+ + PIP + F S+ N +RK +
Sbjct: 826 GAGGVELLQEVVPKEKVV----------PIPE-------GSAFFCLSQTNPLRKGCHTLI 868
Query: 93 EWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIAL 152
F +IL II + + LA E P + + L + F IF E +K+
Sbjct: 869 HHHVFTNLILVFIILSSVSLAAED--PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926
Query: 153 GFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
G H+GS+ R+ +N++D +VV +++ + ++ LR +RVLRPL+ ++ L
Sbjct: 927 GAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGL 986
Query: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNS--TDAEPVGDF- 266
+ V++ + A+ + I ++ MFA IG++ + GKF+ C + T E G F
Sbjct: 987 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-TCTDEAKHTPQECKGSFL 1045
Query: 267 --PCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTN 324
P G + + E W +F NFDN+L A++ +F T EGW +LY
Sbjct: 1046 VYPDGDVSRPLVRE------RLWVNSDF---NFDNVLSAMMALFTVSTFEGWPALLYKAI 1096
Query: 325 DA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKL 375
DA G +N+ ++FI III +FFM+N+ +G + F + E+ E + L
Sbjct: 1097 DAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ-EYQNCELDK 1155
Query: 376 RRQQQIEREL 385
++Q +E L
Sbjct: 1156 NQRQCVEYAL 1165
Score = 101 bits (251), Expect = 1e-20
Identities = 75/292 (25%), Positives = 141/292 (48%), Gaps = 12/292 (4%)
Query: 1420 QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMA 1479
+ QGD+ E +L R C++ + + R NR + + V S + ++
Sbjct: 480 ETQGDEDEEEGALASCTR-CLNKIMKTRVCRRLRRANRV-LRARCRRAVKSNACYWAVLL 537
Query: 1480 MIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFD 1539
++ LNT+ + + + P + + N V +F++E +LK+ G Y +N FD
Sbjct: 538 LVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFD 597
Query: 1540 FVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKAL 1599
V G I + + E+ + +S LR R R+ K+ R ++ L+ + + S K++
Sbjct: 598 CFVVCGGILETTLVEVGAMQP-LGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSI 656
Query: 1600 PYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHE 1659
+ LL+ + I++++GMQ+FG D T R + F TF QAL+ +F+ TGE W+
Sbjct: 657 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNV 715
Query: 1660 IMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
+M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 716 VMYDGIMAYGGPFFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 760
Score = 89.0 bits (219), Expect = 5e-17
Identities = 71/283 (25%), Positives = 129/283 (45%), Gaps = 45/283 (15%)
Query: 1138 LLRRFCHYIVTMRYFEVVILVVIALSSIALAAE---DPVRTDSPRNNALKYLDYIFTGVF 1194
+LR C V +L+++ L+++ +A+E PV + +Y + + +F
Sbjct: 517 VLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQ----EYANKVLLCLF 572
Query: 1195 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1254
T EM++K+ LG P AY +N D VV G ++ I LR +R
Sbjct: 573 TVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVR 628
Query: 1255 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDE 1314
+LR K + L + ++NS+K++ ++L++ LF+ IF+++ +QLF GKF +
Sbjct: 629 LLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTH 688
Query: 1315 SKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHS 1374
+K +D ALLT+F + TGE W +V+
Sbjct: 689 TKRST----------------------------FDTFPQALLTVFQILTGEDWNVVM--- 717
Query: 1375 VDATYEEQGP-SPGYRMELSIFYVVYFVVFPFFFVNIFVALII 1416
D GP PG M + I++++ F+ + +N+F+A+ +
Sbjct: 718 YDGIMAYGGPFFPG--MLVCIYFIILFICGNYILLNVFLAIAV 758
Score = 78.2 bits (191), Expect = 9e-14
Identities = 78/346 (22%), Positives = 141/346 (40%), Gaps = 77/346 (22%)
Query: 1420 QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMA 1479
Q K ++ S +++ RA LT P R W PF+ I+
Sbjct: 53 QHSKHKTVAVASAQRSPRALFC-------LTLANPLRRSCISIVEWK-----PFDILILL 100
Query: 1480 MIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL----NYFR 1532
I N V L + D L+ + VF +F++E VLKI+A+G++ Y R
Sbjct: 101 TIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIR 160
Query: 1533 DAWNVFDFVTVLGSITDILVTE----------IAETNNFINLSFLRLFRAARLIKLLRQG 1582
+ WN+ DF+ V+ + +L+ + ++ LR FR R ++L+
Sbjct: 161 NGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGV 220
Query: 1583 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------GNIALDDDT 1630
++ I+L + +++ L ++ LL+ + IYAIIG+++F ++ ++D
Sbjct: 221 PSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDP 280
Query: 1631 S------------INRH-------------NNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
S +N+ NF F A++ +F+ T E W +++
Sbjct: 281 SPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWM- 339
Query: 1666 SNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
G + + YFVS + SF +LNL + V+ F
Sbjct: 340 ----------QDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 375
Score = 71.2 bits (173), Expect = 1e-11
Identities = 68/295 (23%), Positives = 118/295 (40%), Gaps = 74/295 (25%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N + LA++ + P + +D F G+F E +KIIA F
Sbjct: 1192 FEYLMFLLILLNTVALAMQHY---EQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----F 1244
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD----------------FDLRTLRAVRVLRPL 200
Y + WN D ++V+ I+ A T+ + R RV+R +
Sbjct: 1245 KPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLV 1304
Query: 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDA 260
KL+S ++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 1305 KLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF--------------- 1349
Query: 261 EPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL 320
GK A L +G R NF A+L +F+C T E W +I+
Sbjct: 1350 --------GKVA---LQDGTQINRN---------NNFQTFPQAVLLLFRCATGEAWQEIM 1389
Query: 321 Y-----NTND-----------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
N D G+ + YFI ++ +F ++NL + V+ F
Sbjct: 1390 LASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 6 [Homo sapiens]
Length = 2158
Score = 761 bits (1964), Expect = 0.0
Identities = 431/967 (44%), Positives = 591/967 (61%), Gaps = 94/967 (9%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLD--------------------YIFTGVFTFEMVIKM 1202
SSI+LAAEDPV+ S RN+ L Y D Y+FT +FT E+++KM
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM 972
Query: 1203 IDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTI 1262
G LH G++ R+ +NILD +VVS +L++F S IN +K LRVLRVLRPL+ I
Sbjct: 973 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAI 1029
Query: 1263 KRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDC 1322
R LK V CV +++ + NI+IV L F+FA I VQLFKGK + C+D SK+ E +C
Sbjct: 1030 NRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAEC 1089
Query: 1323 RGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATY 1379
+G Y+ Y+ EV+ QPR W+ F +DNVL A++ LFTVST EGWP +L S+D+
Sbjct: 1090 KGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1149
Query: 1380 EEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERAC 1439
E++GP YR+E+SIF+++Y ++ FF +NIFV +I+TFQEQG++ C L+KN+R C
Sbjct: 1150 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1209
Query: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
+++A+ A+PL RY+P+N+ QYK W V S FEY + +I LNT+ L M+ Y +
Sbjct: 1210 VEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLF 1267
Query: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI---- 1555
++ + LN++FT +F++E +LK+IAF +YF DAWN FD + V+GSI DI +TE+
Sbjct: 1268 KIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAE 1327
Query: 1556 ---------AETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLI 1606
AE N+ I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLI
Sbjct: 1328 HTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1387
Query: 1607 AMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLS 1666
MLFFIYA+IGMQVFG IAL+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C+
Sbjct: 1388 VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1447
Query: 1667 NQAC---DEQANATE----CGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSS 1719
+ C E +N+TE CGS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD S
Sbjct: 1448 GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1507
Query: 1720 ILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMN 1779
ILGPHHLDEF R+WAEYDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV MN
Sbjct: 1508 ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMN 1567
Query: 1780 MPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDL 1839
MP+ N D TV F +TL AL+RTAL IK Q + ELR I +W K LD
Sbjct: 1568 MPL-NSDGTVMFNATLFALVRTALRIK---TEGNLEQANEELRAIIKKIWKRTSMKLLDQ 1623
Query: 1840 LVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQ 1899
+VPP DE+TVGK YA +I +++++ K ++ Q G SQ +SL L+ TL
Sbjct: 1624 VVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQAGLR-TLHD 1680
Query: 1900 TQPAVLR 1906
P + R
Sbjct: 1681 IGPEIRR 1687
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 123 bits (309), Expect = 2e-27
Identities = 76/275 (27%), Positives = 134/275 (48%), Gaps = 35/275 (12%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1235 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1294
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP--------------GSSFGISVLRALRLL 583
P+ YF ++N FD ++VGS+ ++ + P S I+ R R++
Sbjct: 1295 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1354
Query: 584 RIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP- 642
R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+ D T
Sbjct: 1355 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEI 1413
Query: 643 --TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-------GMFSS 686
NF TFP A+L +F+ TGE W +M + ES+ S F+
Sbjct: 1414 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1473
Query: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1474 FYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1505
Score = 121 bits (304), Expect = 7e-27
Identities = 163/748 (21%), Positives = 308/748 (41%), Gaps = 166/748 (22%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAM---VHYNQPRR--------LTTTLYF----- 516
R+V F ++L + L+++ +A V + R + TT++
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 517 -----AEFVFLGLFLTEMSLKM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIK 567
A++VF +F E+ LKM YG L S+ R+ FN D V+ S+ I+
Sbjct: 951 KILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQ 1007
Query: 568 PGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLG 627
+ + +LR LR+LR + L+++V + ++++I +++ + L +FA +G
Sbjct: 1008 SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1067
Query: 628 MQLFGGQF-------------------NFQD-------------ETPTTNFDTFPAAILT 655
+QLF G+ ++D E +FD AA++
Sbjct: 1068 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1127
Query: 656 VFQILTGEDWNAVMYHGIESQGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVD 710
+F + T E W ++Y I+S +++ S +FI+ + + ++N+F+ +
Sbjct: 1128 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1187
Query: 711 NLANAQELTKDEEEMEEAANQKLALQKA 738
E ++ + E NQ+ ++ A
Sbjct: 1188 TFQEQGE--QEYKNCELDKNQRQCVEYA 1213
Score = 109 bits (273), Expect = 3e-23
Identities = 95/344 (27%), Positives = 165/344 (47%), Gaps = 40/344 (11%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALE---QHLPDGDKTPMS--- 127
+ F+FS +N R RI F +IL I+ + I LA E QH +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938
Query: 128 ------------ERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVL 175
+ L + + F IF E +K+ A G HKGS+ RN +N++D +VV
Sbjct: 939 VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVS 998
Query: 176 TGILA---TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFF 232
+++ + ++ LR +RVLRPL+ ++ L+ V++ + A+ + I ++
Sbjct: 999 VSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTL 1058
Query: 233 AILMFAIIGLEFYMGKFHKACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGP 290
MFA IG++ + GK + C +S T+AE G++ K+ + W
Sbjct: 1059 LQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENS 1114
Query: 291 NFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLII 341
F +FDN+L A++ +F T EGW ++LY + D+ G +N+ ++FI II
Sbjct: 1115 KF---DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYII 1171
Query: 342 IGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 385
I +FFM+N+ +G + F ++ E+ E + L ++Q +E L
Sbjct: 1172 IIAFFMMNIFVGFVIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1214
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 64.7 bits (156), Expect = 1e-09
Identities = 64/301 (21%), Positives = 118/301 (39%), Gaps = 80/301 (26%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1241 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1293
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD--------------------LRTLRAVRV 196
Y + WN D ++V+ I+ A T+ + + R RV
Sbjct: 1294 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1353
Query: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256
+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ F K +
Sbjct: 1354 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV----FGKIALND 1409
Query: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
+T+ NF A+L +F+C T E W
Sbjct: 1410 TTEINRNN-------------------------------NFQTFPQAVLLLFRCATGEAW 1438
Query: 317 TDILY---------------NTNDA---AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGE 358
DI+ N+ + G+++ YFI ++ +F ++NL + V+
Sbjct: 1439 QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1498
Query: 359 F 359
F
Sbjct: 1499 F 1499
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 758 bits (1956), Expect = 0.0
Identities = 433/986 (43%), Positives = 593/986 (60%), Gaps = 111/986 (11%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI------------------------ 1555
LK+IAF +YF DAWN FD + V+GSI DI +TE+
Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVL 1327
Query: 1556 -----------AETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCL 1604
AE N+ I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV L
Sbjct: 1328 TAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1387
Query: 1605 LIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSC 1664
LI MLFFIYA+IGMQVFG IAL+D T INR+NNF+TF QA++LLFR ATGEAW +IML+C
Sbjct: 1388 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1447
Query: 1665 LSNQAC---DEQANATE----CGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD 1717
+ + C E +N+TE CGS FA FYF+SF LC+FL++NLFVAVIMDNF+YLTRD
Sbjct: 1448 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1507
Query: 1718 SSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVR 1777
SILGPHHLDEF R+WAEYDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV
Sbjct: 1508 WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVS 1567
Query: 1778 MNMPISNEDMTVHFTSTLMALIRTALEIK-----------------LAPAGTKQHQCDAE 1820
MNMP+ N D TV F +TL AL+RTAL IK PAG + Q + E
Sbjct: 1568 MNMPL-NSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLE-QANEE 1625
Query: 1821 LRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGG 1880
LR I +W K LD +VPP DE+TVGK YA +I +++++ K ++ Q G
Sbjct: 1626 LRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE--QGLVGK 1683
Query: 1881 LSQMGPVSLFHPLKATLEQTQPAVLR 1906
SQ +SL L+ TL P + R
Sbjct: 1684 PSQRNALSLQAGLR-TLHDIGPEIRR 1708
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 115 bits (287), Expect = 7e-25
Identities = 76/297 (25%), Positives = 134/297 (45%), Gaps = 57/297 (19%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKP----------------------------- 568
P+ YF ++N FD ++VGS+ ++ + P
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVAD 1334
Query: 569 -------GSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIV 621
S I+ R R++R+ K+ +R L+ + + S +++ + L+ +
Sbjct: 1335 GFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFF 1394
Query: 622 VFALLGMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHGI----- 673
++A++GMQ+F G+ D T NF TFP A+L +F+ TGE W +M +
Sbjct: 1395 IYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKC 1453
Query: 674 --ESQGGVSK-------GMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
ES+ S F+ FYFI + + ++N+F+A+ +DN LT+D
Sbjct: 1454 APESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1507
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 56.2 bits (134), Expect = 4e-07
Identities = 64/323 (19%), Positives = 118/323 (36%), Gaps = 102/323 (31%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD----------------------------- 187
Y + WN D ++V+ I+ A T+ +
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVA 1333
Query: 188 -------------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAI 234
+ R RV+R +KL+S ++ +L + +K+ L + LL+
Sbjct: 1334 DGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF 1393
Query: 235 LMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGI 294
++A+IG++ F K ++T+
Sbjct: 1394 FIYAVIGMQV----FGKIALNDTTEINRNN------------------------------ 1419
Query: 295 TNFDNILFAILTVFQCITMEGWTDILY---------------NTNDA---AGNTWNWLYF 336
NF A+L +F+C T E W DI+ N+ + G+++ YF
Sbjct: 1420 -NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYF 1478
Query: 337 IPLIIIGSFFMLNLVLGVLSGEF 359
I ++ +F ++NL + V+ F
Sbjct: 1479 ISFYMLCAFLIINLFVAVIMDNF 1501
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 757 bits (1954), Expect = 0.0
Identities = 429/975 (44%), Positives = 589/975 (60%), Gaps = 102/975 (10%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222
SSI+LAAEDPV+ S RN+ L Y D +FT +FT E+ +KM G LH G++ R+ +NIL
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1282
D +VVS +L++F S IN +K LRVLRVLRPL+ I R LK V CV +++ +
Sbjct: 973 DLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1029
Query: 1283 LNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQPR 1339
NI+IV L F+FA I VQLFKGK + C+D SK+ E +C+G Y+ Y+ EV+ QPR
Sbjct: 1030 GNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR 1089
Query: 1340 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVY 1399
W+ F +DNVL A++ LFTVST EGWP +L S+D+ E++GP YR+E+SIF+++Y
Sbjct: 1090 SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1149
Query: 1400 FVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQS 1459
++ FF +NIFV +I+TFQEQG++ C L+KN+R C+++A+ A+PL RY+P+N+
Sbjct: 1150 IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH- 1208
Query: 1460 FQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECV 1519
QYK W V S FEY + +I LNT+ L M+ Y +++ + LN++FT +F++E +
Sbjct: 1209 -QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMI 1267
Query: 1520 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI------------------------ 1555
LK+IAF YF D WNVFDF+ V+GSI D++++E
Sbjct: 1268 LKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIA 1327
Query: 1556 -----------------AETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKA 1598
AE N+ I+++F RLFR RL+KLL +G IR LLWTF++SF+A
Sbjct: 1328 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1387
Query: 1599 LPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWH 1658
LPYV LLI MLFFIYA+IGMQVFG IAL+D T INR+NNF+TF QA++LLFR ATGEAW
Sbjct: 1388 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1447
Query: 1659 EIMLSCLSNQAC---DEQANATE----CGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
+IML+C+ + C E +N+TE CGS FA FYF+SF LC+FL++NLFVAVIMDNF
Sbjct: 1448 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1507
Query: 1712 EYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVA 1771
+YLTRD SILGPHHLDEF R+WAEYDP A GRI + D+ +L+ + PPLG GK CP RVA
Sbjct: 1508 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1567
Query: 1772 YKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWAN 1831
KRLV MNMP+ N D TV F +TL AL+RTAL IK Q + ELR I +W
Sbjct: 1568 CKRLVSMNMPL-NSDGTVMFNATLFALVRTALRIK---TEGNLEQANEELRAIIKKIWKR 1623
Query: 1832 LPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFH 1891
K LD +VPP DE+TVGK YA +I +++++ K ++ Q G SQ +SL
Sbjct: 1624 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE--QGLVGKPSQRNALSLQA 1681
Query: 1892 PLKATLEQTQPAVLR 1906
L+ TL P + R
Sbjct: 1682 GLR-TLHDIGPEIRR 1695
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 127 bits (319), Expect = 1e-28
Identities = 160/728 (21%), Positives = 303/728 (41%), Gaps = 146/728 (20%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTT-TLYFAEFVFLGLFLTEMSL 531
R+V F ++L + L+++ +A Q L++ + VF +F E++L
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 532 KM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK 587
KM YG L S+ R+ FN D V+ S+ I+ + + +LR LR+LR +
Sbjct: 951 KMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLR 1007
Query: 588 VTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------ 635
L+++V + ++++I +++ + L +FA +G+QLF G+
Sbjct: 1008 AINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEA 1067
Query: 636 -------NFQD-------------ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
++D E +FD AA++ +F + T E W ++Y I+S
Sbjct: 1068 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDS 1127
Query: 676 QGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAAN 730
+++ S +FI+ + + ++N+F+ + E ++ + E N
Sbjct: 1128 HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE--QEYKNCELDKN 1185
Query: 731 QKLALQKA 738
Q+ ++ A
Sbjct: 1186 QRQCVEYA 1193
Score = 116 bits (290), Expect = 3e-25
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 24/326 (7%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
+ F+FS +N R RI F +IL I+ + I LA E P + + L
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F IF E +K+ A G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK +
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Query: 251 KACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
C +S T+AE G++ K+ + W F +FDN+L A++ +F
Sbjct: 1057 -TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENSKF---DFDNVLAAMMALF 1109
Query: 309 QCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEF 359
T EGW ++LY + D+ G +N+ ++FI III +FFM+N+ +G + F
Sbjct: 1110 TVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169
Query: 360 AKERERVENRRAFLKLRRQQQIEREL 385
++ E+ E + L ++Q +E L
Sbjct: 1170 QEQGEQ-EYKNCELDKNQRQCVEYAL 1194
Score = 115 bits (287), Expect = 7e-25
Identities = 80/303 (26%), Positives = 138/303 (45%), Gaps = 63/303 (20%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVV-----------W----AAIKPGSSFGISV------ 576
P+ YF +N FDF +++GS+ +V+ W A I GS I++
Sbjct: 1275 PKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPA 1334
Query: 577 ---------------------LRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFL 615
R R++R+ K+ +R L+ + + S +++ + L
Sbjct: 1335 EHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1394
Query: 616 LFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHG 672
+ + ++A++GMQ+F G+ D T NF TFP A+L +F+ TGE W +M
Sbjct: 1395 IVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1453
Query: 673 I-------ESQGGVSK-------GMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 718
+ ES+ S F+ FYFI + + ++N+F+A+ +DN L
Sbjct: 1454 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYL 1510
Query: 719 TKD 721
T+D
Sbjct: 1511 TRD 1513
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 58.5 bits (140), Expect = 7e-08
Identities = 65/329 (19%), Positives = 118/329 (35%), Gaps = 108/329 (32%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1221 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1273
Query: 157 HKGSYLRNGWNVMDFVVVLTGIL------------------------------------- 179
Y + WNV DF++V+ I+
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1333
Query: 180 -----------ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGL 228
A + + R RV+R +KL+S ++ +L + +K+ L + L
Sbjct: 1334 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1393
Query: 229 LLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWP 288
L+ ++A+IG++ F K ++T+
Sbjct: 1394 LIVMLFFIYAVIGMQV----FGKIALNDTTEIN--------------------------- 1422
Query: 289 GPNFGITNFDNILFAILTVFQCITMEGWTDILY---------------NTNDA---AGNT 330
NF A+L +F+C T E W DI+ N+ + G++
Sbjct: 1423 ----RNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1478
Query: 331 WNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
+ YFI ++ +F ++NL + V+ F
Sbjct: 1479 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1507
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 750 bits (1936), Expect = 0.0
Identities = 430/995 (43%), Positives = 591/995 (59%), Gaps = 122/995 (12%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLD--------------------YIFTGVFTFEMVIKM 1202
SSI+LAAEDPV+ S RN+ L Y D Y+FT +FT E+++KM
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM 972
Query: 1203 IDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTI 1262
G LH G++ R+ +NILD +VVS +L++F S IN +K LRVLRVLRPL+ I
Sbjct: 973 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAI 1029
Query: 1263 KRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDC 1322
R LK V CV +++ + NI+IV L F+FA I VQLFKGK + C+D SK+ E +C
Sbjct: 1030 NRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAEC 1089
Query: 1323 RGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATY 1379
+G Y+ Y+ EV+ QPR W+ F +DNVL A++ LFTVST EGWP +L S+D+
Sbjct: 1090 KGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1149
Query: 1380 EEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERAC 1439
E++GP YR+E+SIF+++Y ++ FF +NIFV +I+TFQEQG++ C L+KN+R C
Sbjct: 1150 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1209
Query: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
+++A+ A+PL RY+P+N+ QYK W V S FEY + +I LNT+ L M+ Y +
Sbjct: 1210 VEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLF 1267
Query: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI---- 1555
++ + LN++FT +F++E +LK+IAF YF D WNVFDF+ V+GSI D++++E
Sbjct: 1268 KIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYF 1327
Query: 1556 -------------------------------------AETNNFINLSFLRLFRAARLIKL 1578
AE N+ I+++F RLFR RL+KL
Sbjct: 1328 CDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKL 1387
Query: 1579 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNF 1638
L +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL+D T INR+NNF
Sbjct: 1388 LSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNF 1447
Query: 1639 RTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----CGSDFAYFYFVSF 1691
+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE CGS FA FYF+SF
Sbjct: 1448 QTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISF 1507
Query: 1692 IFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFE 1751
LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP A GRI + D+
Sbjct: 1508 YMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVT 1567
Query: 1752 MLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAG 1811
+L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RTAL IK
Sbjct: 1568 LLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALVRTALRIK---TE 1623
Query: 1812 TKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTR 1871
Q + ELR I +W K LD +VPP DE+TVGK YA +I +++++ K +
Sbjct: 1624 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1683
Query: 1872 DQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
+ Q G SQ +SL L+ TL P + R
Sbjct: 1684 E--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1715
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 121 bits (304), Expect = 7e-27
Identities = 163/748 (21%), Positives = 308/748 (41%), Gaps = 166/748 (22%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAM---VHYNQPRR--------LTTTLYF----- 516
R+V F ++L + L+++ +A V + R + TT++
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 517 -----AEFVFLGLFLTEMSLKM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIK 567
A++VF +F E+ LKM YG L S+ R+ FN D V+ S+ I+
Sbjct: 951 KILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQ 1007
Query: 568 PGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLG 627
+ + +LR LR+LR + L+++V + ++++I +++ + L +FA +G
Sbjct: 1008 SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1067
Query: 628 MQLFGGQF-------------------NFQD-------------ETPTTNFDTFPAAILT 655
+QLF G+ ++D E +FD AA++
Sbjct: 1068 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1127
Query: 656 VFQILTGEDWNAVMYHGIESQGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVD 710
+F + T E W ++Y I+S +++ S +FI+ + + ++N+F+ +
Sbjct: 1128 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1187
Query: 711 NLANAQELTKDEEEMEEAANQKLALQKA 738
E ++ + E NQ+ ++ A
Sbjct: 1188 TFQEQGE--QEYKNCELDKNQRQCVEYA 1213
Score = 115 bits (287), Expect = 7e-25
Identities = 80/303 (26%), Positives = 138/303 (45%), Gaps = 63/303 (20%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1235 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1294
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVV-----------W----AAIKPGSSFGISV------ 576
P+ YF +N FDF +++GS+ +V+ W A I GS I++
Sbjct: 1295 PKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPA 1354
Query: 577 ---------------------LRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFL 615
R R++R+ K+ +R L+ + + S +++ + L
Sbjct: 1355 EHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1414
Query: 616 LFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHG 672
+ + ++A++GMQ+F G+ D T NF TFP A+L +F+ TGE W +M
Sbjct: 1415 IVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1473
Query: 673 I-------ESQGGVSK-------GMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 718
+ ES+ S F+ FYFI + + ++N+F+A+ +DN L
Sbjct: 1474 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYL 1530
Query: 719 TKD 721
T+D
Sbjct: 1531 TRD 1533
Score = 109 bits (273), Expect = 3e-23
Identities = 95/344 (27%), Positives = 165/344 (47%), Gaps = 40/344 (11%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALE---QHLPDGDKTPMS--- 127
+ F+FS +N R RI F +IL I+ + I LA E QH +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938
Query: 128 ------------ERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVL 175
+ L + + F IF E +K+ A G HKGS+ RN +N++D +VV
Sbjct: 939 VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVS 998
Query: 176 TGILA---TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFF 232
+++ + ++ LR +RVLRPL+ ++ L+ V++ + A+ + I ++
Sbjct: 999 VSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTL 1058
Query: 233 AILMFAIIGLEFYMGKFHKACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGP 290
MFA IG++ + GK + C +S T+AE G++ K+ + W
Sbjct: 1059 LQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENS 1114
Query: 291 NFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLII 341
F +FDN+L A++ +F T EGW ++LY + D+ G +N+ ++FI II
Sbjct: 1115 KF---DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYII 1171
Query: 342 IGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 385
I +FFM+N+ +G + F ++ E+ E + L ++Q +E L
Sbjct: 1172 IIAFFMMNIFVGFVIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1214
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 58.5 bits (140), Expect = 7e-08
Identities = 65/329 (19%), Positives = 118/329 (35%), Gaps = 108/329 (32%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1241 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1293
Query: 157 HKGSYLRNGWNVMDFVVVLTGIL------------------------------------- 179
Y + WNV DF++V+ I+
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 180 -----------ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGL 228
A + + R RV+R +KL+S ++ +L + +K+ L + L
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 229 LLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWP 288
L+ ++A+IG++ F K ++T+
Sbjct: 1414 LIVMLFFIYAVIGMQV----FGKIALNDTTEIN--------------------------- 1442
Query: 289 GPNFGITNFDNILFAILTVFQCITMEGWTDILY---------------NTNDA---AGNT 330
NF A+L +F+C T E W DI+ N+ + G++
Sbjct: 1443 ----RNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1498
Query: 331 WNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
+ YFI ++ +F ++NL + V+ F
Sbjct: 1499 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 750 bits (1936), Expect = 0.0
Identities = 430/995 (43%), Positives = 591/995 (59%), Gaps = 122/995 (12%)
Query: 991 AVEKETTEKEATEKEAEIVEADKEKELRNH----QPREPHCDLETSGTVTVGPMHTLPST 1046
+ +KE E++ +K A +K++EL + +E +L++ P P+T
Sbjct: 764 SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESP----PAT 819
Query: 1047 CLQKVEEQPEDADNQRNVTRMGSQPPDPNTI----VHIPVMLTGPLGEATVVPSGNVDLE 1102
+ + QP + +++ S P+P T P M GP P + L+
Sbjct: 820 KINMDDLQPNENEDK-------SPYPNPETTGEEDEEEPEMPVGPRPR----PLSELHLK 868
Query: 1103 SQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIAL 1162
+A P+ S+ F S N R CH IV F +IL I L
Sbjct: 869 EKAV----------------PMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 1163 SSIALAAEDPVRTDSPRNNALKYLD--------------------YIFTGVFTFEMVIKM 1202
SSI+LAAEDPV+ S RN+ L Y D Y+FT +FT E+++KM
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM 972
Query: 1203 IDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTI 1262
G LH G++ R+ +NILD +VVS +L++F S IN +K LRVLRVLRPL+ I
Sbjct: 973 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA---INVVKILRVLRVLRPLRAI 1029
Query: 1263 KRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDC 1322
R LK V CV +++ + NI+IV L F+FA I VQLFKGK + C+D SK+ E +C
Sbjct: 1030 NRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAEC 1089
Query: 1323 RGQYLDYEKEEVE---AQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATY 1379
+G Y+ Y+ EV+ QPR W+ F +DNVL A++ LFTVST EGWP +L S+D+
Sbjct: 1090 KGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1149
Query: 1380 EEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERAC 1439
E++GP YR+E+SIF+++Y ++ FF +NIFV +I+TFQEQG++ C L+KN+R C
Sbjct: 1150 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1209
Query: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
+++A+ A+PL RY+P+N+ QYK W V S FEY + +I LNT+ L M+ Y +
Sbjct: 1210 VEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLF 1267
Query: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI---- 1555
++ + LN++FT +F++E +LK+IAF YF D WNVFDF+ V+GSI D++++E
Sbjct: 1268 KIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYF 1327
Query: 1556 -------------------------------------AETNNFINLSFLRLFRAARLIKL 1578
AE N+ I+++F RLFR RL+KL
Sbjct: 1328 CDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKL 1387
Query: 1579 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNF 1638
L +G IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG IAL+D T INR+NNF
Sbjct: 1388 LSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNF 1447
Query: 1639 RTFLQALMLLFRSATGEAWHEIMLSCLSNQAC---DEQANATE----CGSDFAYFYFVSF 1691
+TF QA++LLFR ATGEAW +IML+C+ + C E +N+TE CGS FA FYF+SF
Sbjct: 1448 QTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISF 1507
Query: 1692 IFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFE 1751
LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYDP A GRI + D+
Sbjct: 1508 YMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVT 1567
Query: 1752 MLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAG 1811
+L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RTAL IK
Sbjct: 1568 LLRRIQPPLGFGKLCPHRVACKRLVSMNMPL-NSDGTVMFNATLFALVRTALRIK---TE 1623
Query: 1812 TKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTR 1871
Q + ELR I +W K LD +VPP DE+TVGK YA +I +++++ K +
Sbjct: 1624 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1683
Query: 1872 DQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR 1906
+ Q G SQ +SL L+ TL P + R
Sbjct: 1684 E--QGLVGKPSQRNALSLQAGLR-TLHDIGPEIRR 1715
Score = 648 bits (1671), Expect = 0.0
Identities = 371/803 (46%), Positives = 486/803 (60%), Gaps = 59/803 (7%)
Query: 63 PVKQNCFTVNR---SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLP 119
P KQ T R +L + N +R+ I EW PFE +IL TI ANC+ LA+ P
Sbjct: 89 PKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFP 148
Query: 120 DGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI- 178
+ D + L+ E F+ IF EA +K+IA G +FH +YLRNGWN++DF++V+ G+
Sbjct: 149 EDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 208
Query: 179 ---------------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 223
L G FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPL
Sbjct: 209 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPL 268
Query: 224 LQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE-PVGD--FPCGKEAP-ARLCEG 279
L I LL+ F I+++AIIGLE +MGK HK C+ A+ P D PC E R C+
Sbjct: 269 LHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQN 328
Query: 280 DTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL 339
T C+ W GP GITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ L
Sbjct: 329 GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTL 388
Query: 340 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399
IIIGSFF+LNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++
Sbjct: 389 IIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID 448
Query: 400 LAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE--GEDRFADLCAVGSPFARASLKSGK 457
ED +E+ P + + S + ++ E G D + C AR + + K
Sbjct: 449 PENEDEGMDEEKP----RNMSMPTSETESVNTENVAGGDIEGENCG-----ARLAHRISK 499
Query: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
++ S Y+RR + R R VK+ FYW+V+ +V LNTL +A HYNQP LT A
Sbjct: 500 SKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
L LF EM LKMY LG ++YF S FN FD V+ G + E + K S GISVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
R +RLLRIFK+T+YW+SL NLV SLLNS++SI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLF 695
+ +T + FD FP ++LTVFQILTGEDWN+VMY GI + GG S GM YFI+L +
Sbjct: 680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFIC 739
Query: 696 GNYTLLNVFLAIAVDNLANAQELTK-DEEEMEEAANQKLALQKAKEVAEVSPMSAANISI 754
GNY LLNVFLAIAVDNLA+A+ LT +EE EE +KLA + E
Sbjct: 740 GNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE-------------- 785
Query: 755 AARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLD 814
++Q + +V E + ++ L+++ A E P ++ + + K+
Sbjct: 786 --KKQELVEKPAVGESKEEKIELKSITAD-----GESPPATKINMDDLQPNENEDKSPYP 838
Query: 815 RPLVV-ELGRDGARGPVGGKARP 836
P E + PVG + RP
Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRP 861
Score = 216 bits (550), Expect = 2e-55
Identities = 179/716 (25%), Positives = 322/716 (44%), Gaps = 113/716 (15%)
Query: 1084 LTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFC 1143
L G G AT+ + + Q GK + + PR ++ CL+ N +RR C
Sbjct: 64 LMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR------ALLCLTLKNPIRRAC 117
Query: 1144 HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIK 1201
IV + FE++IL+ I + +ALA P D N+ L+ ++Y+F +FT E +K
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 1202 MIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAFAFSGSKGKDINT---------IKSLR 1251
+I GLL HP AY R+ WN+LDF IVV G A +K N +K+LR
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALR 237
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-Y 1310
RVLRPL+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK
Sbjct: 238 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
Query: 1311 CTDESKELERDCRGQYLDYEKEEVEAQPRQ--------W---KKYDFHYDNVLWALLTLF 1359
C ++ + E + Q W K ++DN +A+LT+F
Sbjct: 298 CYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 357
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
T EGW VL DA + I++V ++ FF +N+ + ++ F
Sbjct: 358 QCITMEGWTDVLYWVNDAVGRDWP---------WIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query: 1420 QEQ-------GD--KVMSECSLEKNERACIDFAISA---------------KPLTRYMP- 1454
++ GD K+ + LE++ + +D+ A KP MP
Sbjct: 409 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query: 1455 ------------------------------QNRQSFQYKTW---------TFVVSPPFEY 1475
+++ S ++ W V S F +
Sbjct: 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYW 528
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ LNT+ + + Y+ P + N ++F+ E +LK+ + G+ YF +
Sbjct: 529 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V G I + ++ E + + + +S LR R R+ K+ R ++ L+ + + S
Sbjct: 589 NRFDCFVVCGGILETILVE-TKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I++++GMQ+FG + D R + F F Q+L+ +F+ TGE
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGE 706
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W+ +M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 707 DWNSVMYDGIMAYGGPSFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 755
Score = 121 bits (304), Expect = 7e-27
Identities = 163/748 (21%), Positives = 308/748 (41%), Gaps = 166/748 (22%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
F ++++ + N + +A E + ++E D + +F E +K+ +LG
Sbjct: 526 FYWLVIFLVFLNTLTIASEHY---NQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQ- 581
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD------FDLRTLRAVRVLRPLKLVSGIPSLQ 210
+Y + +N D VV GIL T + + LR VR+LR K+ SL
Sbjct: 582 ---AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGK 270
++ S++ ++ + + LLLF I++F+++G++ + GKF+
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF------------------- 679
Query: 271 EAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNT 330
+ + R + FDN ++LTVFQ +T E W ++Y+ A G
Sbjct: 680 --------DEMQTRR---------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722
Query: 331 -----WNWLYFIPLIIIGSFFMLNLVLGVLSGEFA-------------KERERVENRRAF 372
+YFI L I G++ +LN+ L + A +E+ER + R
Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782
Query: 373 LKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAE 432
++Q+ +E+ G +++E + + A+ +SP ATK + +DL E
Sbjct: 783 SPEKKQELVEKPAVG------ESKEEKIELKSITADGESP------PATKINMDDLQPNE 830
Query: 433 EG-------------EDRFADLCAVGS---PFARASLKSGKT---ESSSYFR-RKEKMFR 472
ED VG P + LK E+S++F FR
Sbjct: 831 NEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFR 890
Query: 473 FFIRRMVKAQSFYWVVLCVVALNTLCVAM---VHYNQPRR--------LTTTLYF----- 516
R+V F ++L + L+++ +A V + R + TT++
Sbjct: 891 LQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIAL 950
Query: 517 -----AEFVFLGLFLTEMSLKM--YG--LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIK 567
A++VF +F E+ LKM YG L S+ R+ FN D V+ S+ I+
Sbjct: 951 KILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF---GIQ 1007
Query: 568 PGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLG 627
+ + +LR LR+LR + L+++V + ++++I +++ + L +FA +G
Sbjct: 1008 SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1067
Query: 628 MQLFGGQF-------------------NFQD-------------ETPTTNFDTFPAAILT 655
+QLF G+ ++D E +FD AA++
Sbjct: 1068 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1127
Query: 656 VFQILTGEDWNAVMYHGIESQGGVSKGMFS-----SFYFIVLTLFGNYTLLNVFLAIAVD 710
+F + T E W ++Y I+S +++ S +FI+ + + ++N+F+ +
Sbjct: 1128 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1187
Query: 711 NLANAQELTKDEEEMEEAANQKLALQKA 738
E ++ + E NQ+ ++ A
Sbjct: 1188 TFQEQGE--QEYKNCELDKNQRQCVEYA 1213
Score = 115 bits (287), Expect = 7e-25
Identities = 80/303 (26%), Positives = 138/303 (45%), Gaps = 63/303 (20%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
+V + F +++ ++ LNT+C+AM HY Q + +F GLF EM LK+
Sbjct: 1235 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1294
Query: 538 PRSYFRSSFNCFDFGVIVGSVFEVV-----------W----AAIKPGSSFGISV------ 576
P+ YF +N FDF +++GS+ +V+ W A I GS I++
Sbjct: 1295 PKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPA 1354
Query: 577 ---------------------LRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFL 615
R R++R+ K+ +R L+ + + S +++ + L
Sbjct: 1355 EHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1414
Query: 616 LFLFIVVFALLGMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHG 672
+ + ++A++GMQ+F G+ D T NF TFP A+L +F+ TGE W +M
Sbjct: 1415 IVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1473
Query: 673 I-------ESQGGVSK-------GMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 718
+ ES+ S F+ FYFI + + ++N+F+A+ +DN L
Sbjct: 1474 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYL 1530
Query: 719 TKD 721
T+D
Sbjct: 1531 TRD 1533
Score = 109 bits (273), Expect = 3e-23
Identities = 95/344 (27%), Positives = 165/344 (47%), Gaps = 40/344 (11%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALE---QHLPDGDKTPMS--- 127
+ F+FS +N R RI F +IL I+ + I LA E QH +
Sbjct: 879 AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938
Query: 128 ------------ERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVL 175
+ L + + F IF E +K+ A G HKGS+ RN +N++D +VV
Sbjct: 939 VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVS 998
Query: 176 TGILA---TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFF 232
+++ + ++ LR +RVLRPL+ ++ L+ V++ + A+ + I ++
Sbjct: 999 VSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTL 1058
Query: 233 AILMFAIIGLEFYMGKFHKACFPNS--TDAEPVGDFPCGKEAPARLCEGDTECREYWPGP 290
MFA IG++ + GK + C +S T+AE G++ K+ + W
Sbjct: 1059 LQFMFACIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEV---DHPIIQPRSWENS 1114
Query: 291 NFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA----AGNTWNW-----LYFIPLII 341
F +FDN+L A++ +F T EGW ++LY + D+ G +N+ ++FI II
Sbjct: 1115 KF---DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYII 1171
Query: 342 IGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 385
I +FFM+N+ +G + F ++ E+ E + L ++Q +E L
Sbjct: 1172 IIAFFMMNIFVGFVIVTFQEQGEQ-EYKNCELDKNQRQCVEYAL 1214
Score = 83.2 bits (204), Expect = 3e-15
Identities = 70/295 (23%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L+ + +F +F++E LK+IA+G+L
Sbjct: 125 PFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184
Query: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---------INLSFLRLFRAARL 1575
Y R+ WN+ DF+ V+ + ++ + + + ++ LR FR R
Sbjct: 185 FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244
Query: 1576 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1621
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 245 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304
Query: 1622 GNIALDDDTSI-----------------------NRHN--NFRTFLQALMLLFRSATGEA 1656
++ +DD S +H NF F A++ +F+ T E
Sbjct: 305 ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364
Query: 1657 WHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
W +++ N A G D+ + YFV+ I + SF +LNL + V+ F
Sbjct: 365 WTDVLYWV--NDAV---------GRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Score = 58.5 bits (140), Expect = 7e-08
Identities = 65/329 (19%), Positives = 118/329 (35%), Gaps = 108/329 (32%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ I+ N I LA++ + G ++ F G+F E +K+IA F
Sbjct: 1241 FEYLMFVLILLNTICLAMQHY---GQSCLFKIAMNILNMLFTGLFTVEMILKLIA----F 1293
Query: 157 HKGSYLRNGWNVMDFVVVLTGIL------------------------------------- 179
Y + WNV DF++V+ I+
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 180 -----------ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGL 228
A + + R RV+R +KL+S ++ +L + +K+ L + L
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 229 LLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWP 288
L+ ++A+IG++ F K ++T+
Sbjct: 1414 LIVMLFFIYAVIGMQV----FGKIALNDTTEIN--------------------------- 1442
Query: 289 GPNFGITNFDNILFAILTVFQCITMEGWTDILY---------------NTNDA---AGNT 330
NF A+L +F+C T E W DI+ N+ + G++
Sbjct: 1443 ----RNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1498
Query: 331 WNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
+ YFI ++ +F ++NL + V+ F
Sbjct: 1499 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
subunit [Homo sapiens]
Length = 1873
Score = 735 bits (1898), Expect = 0.0
Identities = 380/773 (49%), Positives = 513/773 (66%), Gaps = 38/773 (4%)
Query: 1123 PIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNA 1182
PI SS F SPTN +R CH IV +F IL+ I LSS ALAAEDP+R DS RN
Sbjct: 772 PIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQI 831
Query: 1183 LKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGK 1242
LK+ D FT VFT E+V+KM G LH G++ R+ +N+LD +VV+ +L++ S
Sbjct: 832 LKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSA-- 889
Query: 1243 DINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQ 1302
I+ +K LRVLRVLRPL+ I R LK V C+ ++ + NI++V L F+FA I VQ
Sbjct: 890 -ISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQ 948
Query: 1303 LFKGKFFYCTDESKELERDCRGQYLDY---EKEEVEAQPRQWKKYDFHYDNVLWALLTLF 1359
LFKGKFF CTD SK E +CRG Y Y + ++E + R+W DFH+DNVL A+++LF
Sbjct: 949 LFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLF 1008
Query: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
TVST EGWP +L ++D+ E+ GP R+E++IF+++Y ++ FF +NIFV +I+TF
Sbjct: 1009 TVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTF 1068
Query: 1420 QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMA 1479
QEQG+ C L+KN+R C+ +A+ A+PL Y+P+N +QY+ W V S FEY + A
Sbjct: 1069 QEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKN--PYQYQVWYIVTSSYFEYLMFA 1126
Query: 1480 MIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFD 1539
+I LNT+ L M+ Y+ + + LN+ FT +F++E +LK++AF YF D WNVFD
Sbjct: 1127 LIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFD 1186
Query: 1540 FVTVLGSITDILVTEI---------------------AETNNFINLSFLRLFRAARLIKL 1578
F+ V+GSI D++++EI + + I+ +F RLFR RLIKL
Sbjct: 1187 FLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKL 1246
Query: 1579 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNF 1638
L + +R LLWTF++SF+ALPYV LLI MLFFIYA+IGMQ+FG IAL D T INR+NNF
Sbjct: 1247 LSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNF 1306
Query: 1639 RTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATE-----CGSDFAYFYFVSFIF 1693
+TF QA++LLFR ATGEAW EI+L+C + CD +++ CG++FAY+YF+SF
Sbjct: 1307 QTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYM 1366
Query: 1694 LCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEML 1753
LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF +WAEYDP A GRI + D+ +L
Sbjct: 1367 LCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLL 1426
Query: 1754 KHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTK 1813
+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RTAL+IK
Sbjct: 1427 RRIQPPLGFGKFCPHRVACKRLVGMNMPL-NSDGTVTFNATLFALVRTALKIK---TEGN 1482
Query: 1814 QHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQ 1866
Q + ELR I +W K LD ++PP DE+TVGK YA +I + +++
Sbjct: 1483 FEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRK 1535
Score = 617 bits (1591), Expect = e-176
Identities = 337/687 (49%), Positives = 447/687 (65%), Gaps = 53/687 (7%)
Query: 73 RSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD 132
R+LF + +N +RK I EW PFE +IL TI ANC+ LA+ +P+ D ++ L+
Sbjct: 29 RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88
Query: 133 TEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI-------------- 178
E +F+ +F EA +KIIA GF+FH+ +YLR+GWNV+DF +V G+
Sbjct: 89 LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148
Query: 179 ---LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIL 235
+++ G D++ LRA RVLRPL+LVSG+PSLQVVL SI KAM+PL I LL+ F ++
Sbjct: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208
Query: 236 MFAIIGLEFYMGKFHKACFPNSTD----AEPVGDFPCGKEAPARLCE-GDTECREYWPGP 290
++AIIGLE + GK HK C+ TD E PC + R C +ECR WPGP
Sbjct: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268
Query: 291 NFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNL 350
N GIT+FDN F++LTV+QCITMEGWTD+LY NDA GN W W+YF+ LI++GSFF+LNL
Sbjct: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 328
Query: 351 VLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEK 410
VLGVLSGEF KERE+ ++R F KLR +QQ++ +L GY+ WI + EVM E+ R E K
Sbjct: 329 VLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQG-EVMDVEDFR--EGK 385
Query: 411 SPLDVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKM 470
LD E G D S + A L + ++R+ ++
Sbjct: 386 LSLD-----------------EGGSD-------TESLYEIAGLNK-IIQFIRHWRQWNRI 420
Query: 471 FRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMS 530
FR+ +VK++ FYW+V+ +VALNTL +A H+NQP LT A V L LF TEM
Sbjct: 421 FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEML 480
Query: 531 LKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTK 590
+KMYGLG R YF S FN FD V+ + E++ + GISVLR +RLLRIFK+TK
Sbjct: 481 MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK 540
Query: 591 YWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD-ETPTTNFDTF 649
YW+SL NLV SLLNS++SI SLL LLFLFIV+FALLGMQLFGG+++F+D E +NFD F
Sbjct: 541 YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNF 600
Query: 650 PAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLFGNYTLLNVFLAIA 708
P A+++VFQ+LTGEDW ++MY+GI + GG S GM YFI+L + GNY LLNVFLAIA
Sbjct: 601 PQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA 660
Query: 709 VDNLANAQELTKDEE-EMEEAANQKLA 734
VDNLA A+ LT ++ + EE +K++
Sbjct: 661 VDNLAEAESLTSAQKAKAEEKKRRKMS 687
Score = 218 bits (555), Expect = 6e-56
Identities = 173/656 (26%), Positives = 300/656 (45%), Gaps = 90/656 (13%)
Query: 1126 PYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNAL 1183
P ++FCL+ N LR+ C IV + FE +IL+ I + +ALA P+ D N L
Sbjct: 27 PPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGL 86
Query: 1184 KYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAF-------- 1234
+ L+Y F VF+ E +K+I G L H AY R WN+LDF IV G
Sbjct: 87 EKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQ 146
Query: 1235 ---AFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYML 1291
A SKG ++ +K+LR RVLRPL+ + +P L+ V + + ++ + +I ++ +
Sbjct: 147 SHTAPMSSKGAGLD-VKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLF 205
Query: 1292 FMFIFAVIAVQLFKGK-----FFYCTD--------ESKELERDCRGQYLDYEKEEVEAQP 1338
+ I+A+I ++LFKGK +F TD E R G+ E
Sbjct: 206 MVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGW 265
Query: 1339 RQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVV 1398
H+DN +++LT++ T EGW VL DA E I++V
Sbjct: 266 PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWP---------WIYFVT 316
Query: 1399 YFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEK-NERACIDFAISAK---------- 1447
++ FF +N+ + ++ F ++ +K S + +K E+ +D +
Sbjct: 317 LILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVM 376
Query: 1448 --------------------------------PLTRYMPQNRQSFQYKTWTFVVSPPFEY 1475
R+ Q + F++K V S F +
Sbjct: 377 DVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYW 436
Query: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
++ ++ALNT+ + + ++ P + N V S+F+ E ++K+ G+ YF +
Sbjct: 437 LVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIF 496
Query: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
N FD V I +IL+ E + +S LR R R+ K+ + ++ L+ + + S
Sbjct: 497 NRFDCFVVCSGILEILLVESGAMTP-LGISVLRCIRLLRIFKITKYWTSLSNLVASLLNS 555
Query: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
+++ + LL+ + I+A++GMQ+FG +DT + R +NF F QAL+ +F+ TGE
Sbjct: 556 IRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEV-RRSNFDNFPQALISVFQVLTGE 614
Query: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
W +M + + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 615 DWTSMMYNGIMAYGGPSYPGMLVC------IYFI-ILFVCGNYILLNVFLAIAVDN 663
Score = 130 bits (326), Expect = 2e-29
Identities = 159/714 (22%), Positives = 301/714 (42%), Gaps = 127/714 (17%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD-TEPYFIGIFCFEAGIKIIALGFV 155
F ++++ + N + +A E H ++ RL D + +F E +K+ LG
Sbjct: 434 FYWLVILIVALNTLSIASEHH----NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGL- 488
Query: 156 FHKGSYLRNGWNVMDFVVVLTGIL------ATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Y + +N D VV +GIL + A T + LR +R+LR K+ SL
Sbjct: 489 ---RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSL 545
Query: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
++ S++ ++ + + LLLF I++FA++G++ + G++ DF
Sbjct: 546 SNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY---------------DFE-- 588
Query: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
DTE R +NFDN A+++VFQ +T E WT ++YN A G
Sbjct: 589 ----------DTEVRR---------SNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGG 629
Query: 330 TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 384
+YFI L + G++ +LN+ L + A+ ++A + ++++++ +
Sbjct: 630 PSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKG 689
Query: 385 LNGY-----------LEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE 433
L LE K E + + + E +S ++ +K D +E
Sbjct: 690 LPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSA---DFPGDDE 746
Query: 434 GEDRFADLCAVGSPFARASLKSGKT---ESSSYFR-RKEKMFRFFIRRMVKAQSFYWVVL 489
++ L P A LK E+SS+F R R+V A F +L
Sbjct: 747 EDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFIL 806
Query: 490 CVVALNTLCVAMVHYNQPRRLTTT----LYFAEFVFLGLFLTEMSLKM--YG--LGPRSY 541
+ L++ +A P R + L + F +F E+ LKM YG L S+
Sbjct: 807 LFILLSSAALAA---EDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSF 863
Query: 542 FRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVS 601
R+ FN D V+ S+ + ++ + + +LR LR+LR + L+++V
Sbjct: 864 CRNYFNMLDLLVVAVSLISM---GLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQC 920
Query: 602 LLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN-------------------FQDETP 642
+ ++ +I +++ + L +FA +G+QLF G+F ++D P
Sbjct: 921 MFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDP 980
Query: 643 TT-------------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS---- 685
+FD +A++++F + T E W ++Y I+S +++
Sbjct: 981 MQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVE 1040
Query: 686 -SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKA 738
+ +FI+ + + ++N+F+ + E E+++ NQ+ +Q A
Sbjct: 1041 MAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK--NQRQCVQYA 1092
Score = 112 bits (280), Expect = 4e-24
Identities = 74/288 (25%), Positives = 139/288 (48%), Gaps = 41/288 (14%)
Query: 471 FRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMS 530
+++ + +V + F +++ ++ LNT+C+ M HYNQ ++ F +F EM
Sbjct: 1107 YQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMI 1166
Query: 531 LKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAI--------------------KPGS 570
LK+ R YF +N FDF +++GS+ +V+ + I P
Sbjct: 1167 LKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDE 1226
Query: 571 SFGIS--VLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 628
S IS R R++R+ K+ +R L+ + + S +++ + L+ + ++A++GM
Sbjct: 1227 SARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1286
Query: 629 QLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMY---HG--IESQGGVS 680
Q+F G+ D T NF TFP A+L +F+ TGE W ++ +G + + +
Sbjct: 1287 QMF-GKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYA 1345
Query: 681 KG-------MFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
G F+ +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 1346 PGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF---DYLTRD 1390
Score = 111 bits (277), Expect = 9e-24
Identities = 92/325 (28%), Positives = 157/325 (48%), Gaps = 22/325 (6%)
Query: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
S F+FS N +R RI F IL I+ + LA E P + ++ L
Sbjct: 778 SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAED--PIRADSMRNQILKHF 835
Query: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
+ F +F E +K+ G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 836 DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKI 895
Query: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
LR +RVLRPL+ ++ L+ V++ + A+ + I L+ MFA IG++ + GKF
Sbjct: 896 LRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFF 955
Query: 251 KAC-FPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQ 309
+ T+ E G + K+ E RE W +F +FDN+L A++++F
Sbjct: 956 RCTDLSKMTEEECRGYYYVYKDGDPMQIE--LRHRE-WVHSDF---HFDNVLSAMMSLFT 1009
Query: 310 CITMEGWTDILYNTNDA----AGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFA 360
T EGW +LY D+ G +N ++FI II+ +FFM+N+ +G + F
Sbjct: 1010 VSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTF- 1068
Query: 361 KERERVENRRAFLKLRRQQQIEREL 385
+E+ E + L ++Q ++ L
Sbjct: 1069 QEQGETEYKNCELDKNQRQCVQYAL 1093
Score = 101 bits (251), Expect = 1e-20
Identities = 78/288 (27%), Positives = 143/288 (49%), Gaps = 45/288 (15%)
Query: 1138 LLRRFCHYIVTMRYFEVVILVVIALSSIALAAE---DPVRTDSPRNNALKYLDYIFTGVF 1194
+ R CH IV + F ++++++AL+++++A+E P+ ++ A + L +F
Sbjct: 420 IFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVL----LSLF 475
Query: 1195 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1254
T EM++KM LGL YF ++N D VV ++ S I LR +R
Sbjct: 476 TTEMLMKMYGLGLR----QYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIR 531
Query: 1255 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDE 1314
+LR K K L + ++NS++++ ++L++ LF+ IFA++ +QLF G++
Sbjct: 532 LLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY------ 585
Query: 1315 SKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHS 1374
D+E EV ++DN AL+++F V TGE W ++ +
Sbjct: 586 -------------DFEDTEVRRS---------NFDNFPQALISVFQVLTGEDWTSMMYNG 623
Query: 1375 VDATYEEQGPS-PGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQE 1421
+ A GPS PG M + I++++ FV + +N+F+A+ + E
Sbjct: 624 IMA---YGGPSYPG--MLVCIYFIILFVCGNYILLNVFLAIAVDNLAE 666
Score = 85.1 bits (209), Expect = 7e-16
Identities = 87/391 (22%), Positives = 164/391 (41%), Gaps = 84/391 (21%)
Query: 478 MVKAQSFYWVVLCVVALNTLCVAMVHY-----NQPRRLTTTLYFAEFVFLGLFLTEMSLK 532
+V+ + F ++L + N CVA+ Y + L L E+ FL +F E ++K
Sbjct: 47 IVEWKPFETIILLTIFAN--CVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMK 104
Query: 533 MYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAIK-----------PGSSFGISVL 577
+ G +Y RS +N DF ++ VF V+ + G+ + L
Sbjct: 105 IIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKAL 164
Query: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN- 636
RA R+LR ++ SL+ ++ S+ +M + + L+ ++++A++G++LF G+ +
Sbjct: 165 RAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHK 224
Query: 637 ------------FQDETPT-----------------------------TNFDTFPAAILT 655
++E P+ T+FD F ++LT
Sbjct: 225 TCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLT 284
Query: 656 VFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
V+Q +T E W V+Y ++ G + YF+ L L G++ +LN+ L + +
Sbjct: 285 VYQCITMEGWTDVLYWVNDAIG----NEWPWIYFVTLILLGSFFILNLVLGVL------S 334
Query: 716 QELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQL 775
E TK+ E+ A + QK +E ++ +S + + V + R +L
Sbjct: 335 GEFTKEREK----AKSRGTFQKLREKQQLDEDLRGYMSWITQ----GEVMDVEDFREGKL 386
Query: 776 RLQNLRASCEALYSEMDPEERLRFATTRHLR 806
L + E+LY + ++F RH R
Sbjct: 387 SLDEGGSDTESLYEIAGLNKIIQF--IRHWR 415
Score = 82.8 bits (203), Expect = 4e-15
Identities = 79/354 (22%), Positives = 152/354 (42%), Gaps = 68/354 (19%)
Query: 1099 VDLESQAEGK-KEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVIL 1157
V + Q E + K E D R + + + C P N + YIVT YFE ++
Sbjct: 1066 VTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMF 1125
Query: 1158 VVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRD 1217
+I L++I L + +++ N+ L+ FT +FT EM++K+ + YF D
Sbjct: 1126 ALIMLNTICLGMQHYNQSEQ-MNHISDILNVAFTIIFTLEMILKL----MAFKARGYFGD 1180
Query: 1218 LWNILDFIVVSGALVAFAFS---------------GSKGKDINTIKSLRV-------LRV 1255
WN+ DF++V G+++ S G +++ +S R+ RV
Sbjct: 1181 PWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRV 1240
Query: 1256 LRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDES 1315
+R +K + R ++ + + S + + + ++ ++ FI+AVI +Q+F GK +
Sbjct: 1241 MRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKI--ALVDG 1297
Query: 1316 KELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSV 1375
++ R + ++ A+L LF +TGE W +L +
Sbjct: 1298 TQINR------------------------NNNFQTFPQAVLLLFRCATGEAWQEIL---L 1330
Query: 1376 DATY-----EEQGPSPGYRMELS-----IFYVVYFVVFPFFFVNIFVALIIITF 1419
+Y E +PG +++ ++++ F +N+FVA+I+ F
Sbjct: 1331 ACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1384
Score = 75.9 bits (185), Expect = 4e-13
Identities = 74/297 (24%), Positives = 124/297 (41%), Gaps = 68/297 (22%)
Query: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
PFE I+ I N V L + D L L+ L F +FS+E +KIIA+G L
Sbjct: 52 PFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFL 111
Query: 1529 ----NYFRDAWNVFDFVTV-LGSITDIL---------VTEIAETNNFINLSFLRLFRAAR 1574
Y R WNV DF V LG T IL ++ +++ LR FR R
Sbjct: 112 FHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLR 171
Query: 1575 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN--------IAL 1626
++L+ +++++L + ++ L ++ LL+ + IYAIIG+++F I
Sbjct: 172 PLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGT 231
Query: 1627 DDDTSINRHN--------------------------------NFRTFLQALMLLFRSATG 1654
D ++ +F F +++ +++ T
Sbjct: 232 DIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITM 291
Query: 1655 EAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
E W +++ N A G+++ + YFV+ I L SF +LNL + V+ F
Sbjct: 292 EGWTDVLYWV--NDAI---------GNEWPWIYFVTLILLGSFFILNLVLGVLSGEF 337
Score = 64.7 bits (156), Expect = 1e-09
Identities = 67/307 (21%), Positives = 117/307 (38%), Gaps = 86/307 (28%)
Query: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
FEY++ A I+ N I L ++ + +S+ L+ F IF E +K++A F
Sbjct: 1120 FEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVA---FTIIFTLEMILKLMA----F 1172
Query: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFDL---------------------------- 188
Y + WNV DF++V+ I+ ++ D
Sbjct: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232
Query: 189 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGK 248
R RV+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF--- 1289
Query: 249 FHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
GK A L +G R NF A+L +F
Sbjct: 1290 --------------------GKIA---LVDGTQINRN---------NNFQTFPQAVLLLF 1317
Query: 309 QCITMEGWTDILY----------------NTNDAAGNTWNWLYFIPLIIIGSFFMLNLVL 352
+C T E W +IL G + + YFI ++ +F ++NL +
Sbjct: 1318 RCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFV 1377
Query: 353 GVLSGEF 359
V+ F
Sbjct: 1378 AVIMDNF 1384
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 312 bits (799), Expect = 3e-84
Identities = 209/685 (30%), Positives = 363/685 (52%), Gaps = 35/685 (5%)
Query: 1139 LRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP-VRTDSPRNNALKYLDYIFTGVFTFE 1197
+R+ C+ IV +FE I+++I LSS ALA ED + L+Y D IFT +F E
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
Query: 1198 MVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLR 1257
M++K I G YF + W LDF++V +LV + D+ IKSLR LR LR
Sbjct: 1230 MLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285
Query: 1258 PLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYC---TDE 1314
PL+ + R ++ V + ++ ++ +++N+L+V ++F IF+++ V LF GKF+ C TD
Sbjct: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDG 1345
Query: 1315 SKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHS 1374
S+ + + V +Q +WK ++DNV L+L V+T +GW +++ +
Sbjct: 1346 SRFPASQVPNRSECFALMNV-SQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAA 1404
Query: 1375 VDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEK 1434
VD+ ++ P Y + + I++VV+ + FF +N+F+ +II F +Q K+ +
Sbjct: 1405 VDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1464
Query: 1435 NERACIDFA---ISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMK 1491
E+ A + +K + +P+ Q + V + F+ IM +I LN V +M++
Sbjct: 1465 EEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVE 1524
Query: 1492 FYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDIL 1551
+L +N+VF +F+ ECVLK+I+ YF WN+FDFV V+ SI +
Sbjct: 1525 KEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHY-YFTVGWNIFDFVVVIISIVGMF 1583
Query: 1552 VTEIAETNNFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1608
+ ++ ET F++ + R+ R A R+++L++ IR LL+ + S AL + LL+ +
Sbjct: 1584 LADLIET-YFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFL 1642
Query: 1609 LFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQ 1668
+ FIYAI GM F + +D IN NF TF +++ LF+ T W ++ L+++
Sbjct: 1643 VMFIYAIFGMSNFAYVKKED--GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSK 1700
Query: 1669 A--CDEQ------ANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSS 1719
CD + + +CG+ FYFVS+I + +++N+++AVI++NF T +S+
Sbjct: 1701 PPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEEST 1760
Query: 1720 -ILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRM 1778
L + F VW ++DP A I ++ + + + PPL + K P +V +L+ M
Sbjct: 1761 EPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAK--PNKV---QLIAM 1815
Query: 1779 NMPISNEDMTVHFTSTLMALIRTAL 1803
++P+ + D +H L A + L
Sbjct: 1816 DLPMVSGD-RIHCLDILFAFTKRVL 1839
Score = 177 bits (449), Expect = 1e-43
Identities = 160/681 (23%), Positives = 296/681 (43%), Gaps = 119/681 (17%)
Query: 84 VRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCF 143
+RK +I E FE I+ I+ + LA E + KT + L+ + F IF
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKT-IKIILEYADKIFTYIFIL 1228
Query: 144 EAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFD------LRTLRAVRVL 197
E +K IA G+ +Y N W +DF++V ++ +++LR +R L
Sbjct: 1229 EMLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1284
Query: 198 RPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNS 257
RPL+ +S ++VV+ +++ A+ ++ + L+ L+F+I+G+ + GKF++ N+
Sbjct: 1285 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECI--NT 1342
Query: 258 TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWT 317
TD FP + C + N + NFDN+ L++ Q T +GWT
Sbjct: 1343 TDGSR---FPASQVPNRSECFALMNVSQNVRWKNLKV-NFDNVGLGYLSLLQVATFKGWT 1398
Query: 318 DILYNTNDAAG---------NTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVEN 368
I+Y D+ + + ++YF+ II GSFF LNL +GV+ F +++
Sbjct: 1399 IIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQK----- 1453
Query: 369 RRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDL 428
++L G +++ + EE +K + +K+ +KK +
Sbjct: 1454 --------------KKLGG--------QDIFMTEE-----QKKYYNAMKKLGSKKPQK-- 1484
Query: 429 IHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVV 488
P R K + I +V Q+F +
Sbjct: 1485 ------------------PIPRPGNK----------------IQGCIFDLVTNQAFDISI 1510
Query: 489 LCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNC 548
+ ++ LN + + + Q + +T LY+ VF+ LF E LK+ L YF +N
Sbjct: 1511 MVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNI 1569
Query: 549 FDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRI---FKVTKYWSSLRNLVVSLLNS 605
FDF V++ S+ + A + ++ R +RL RI ++ K +R L+ +L+ S
Sbjct: 1570 FDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMS 1629
Query: 606 MKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDW 665
+ ++ ++ LLFL + ++A+ GM F NF+TF +++ +FQI T W
Sbjct: 1630 LPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGW 1689
Query: 666 NAVM----------------YHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAV 709
+ ++ + G +G FYF+ + ++N+++A+ +
Sbjct: 1690 DGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVIL 1749
Query: 710 DNLANAQE-----LTKDEEEM 725
+N + A E L++D+ EM
Sbjct: 1750 ENFSVATEESTEPLSEDDFEM 1770
Score = 155 bits (393), Expect = 3e-37
Identities = 106/394 (26%), Positives = 194/394 (49%), Gaps = 39/394 (9%)
Query: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
F +L++ S + +R+ + +I F +I+ TI+ NCI + + PD K
Sbjct: 100 FNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-PDWTK----- 153
Query: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDL 188
+ E F GI+ FE+ +KI+A GF + ++LR+ WN +DFVV++ L ++
Sbjct: 154 ---NVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNV 210
Query: 189 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGK 248
LR RVLR LK +S IP L+ ++ ++++++ L + +L F + +FA+IGL+ +MG
Sbjct: 211 SALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGN 270
Query: 249 FHKACFPNSTD-----------AEPVGDFP--------------CGKEAPARLCEGDTEC 283
CF NS + E DF CG + C C
Sbjct: 271 LKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTC 330
Query: 284 REYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
+ P++G T+FD +A L +F+ +T + W ++ T AAG T+ ++F+ +I +G
Sbjct: 331 VKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTY-MIFFVVVIFLG 389
Query: 344 SFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEE 403
SF+++NL+L V++ + ++ + +L QQ ++R E AE + A
Sbjct: 390 SFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEE----AEAIAAAAA 445
Query: 404 DRNAEEKSPLDVLKRAATKKSRNDLIHAEEGEDR 437
+ + +S + L ++++ S+ A+E +R
Sbjct: 446 EYTSIRRSRIMGLSESSSETSKLSSKSAKERRNR 479
Score = 129 bits (323), Expect = 4e-29
Identities = 85/261 (32%), Positives = 144/261 (55%), Gaps = 20/261 (7%)
Query: 487 VVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSF 546
+ +C+V LNTL +AM H+ L VF G+F EM LK+ + P YF+ +
Sbjct: 739 ITICIV-LNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGW 797
Query: 547 NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSM 606
N FD ++ S+ E+ A ++ G+SVLR+ RLLR+FK+ K W +L L+ + NS+
Sbjct: 798 NIFDSLIVTLSLVELFLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 852
Query: 607 KSIISLLFLLFLFIVVFALLGMQLFGGQF-------NFQDETPTTNFDTFPAAILTVFQI 659
++ +L +L + + +FA++GMQLFG + N P + + F + L VF++
Sbjct: 853 GALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRV 912
Query: 660 LTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 719
L GE W M+ +E G + M Y +V+ + GN +LN+FLA+ + + ++ LT
Sbjct: 913 LCGE-WIETMWDCMEVAG---QAMCLIVYMMVMVI-GNLVVLNLFLALLLSSF-SSDNLT 966
Query: 720 KDEEEMEEAANQKLALQKAKE 740
EE+ +A N ++A+ + K+
Sbjct: 967 AIEED-PDANNLQIAVTRIKK 986
Score = 116 bits (291), Expect = 2e-25
Identities = 74/252 (29%), Positives = 132/252 (52%), Gaps = 26/252 (10%)
Query: 1467 FVVSPPF-EYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAF 1525
F+V PF + I I LNT+ + M+ + E++ +L N+VFT +F+ E VLK+IA
Sbjct: 728 FIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAM 787
Query: 1526 GVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTI 1585
YF+ WN+FD + V S+ ++ + ++ LS LR FR R+ KL + T+
Sbjct: 788 DPYEYFQVGWNIFDSLIVTLSLVELFLADVE------GLSVLRSFRLLRVFKLAKSWPTL 841
Query: 1586 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN------IALDDDTSINRHNNFR 1639
+L+ S AL + L++A++ FI+A++GMQ+FG ++DD ++ R +
Sbjct: 842 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRW-HMN 900
Query: 1640 TFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLM 1699
F + +++FR GE W E M C+ G ++ + + + ++
Sbjct: 901 DFFHSFLIVFRVLCGE-WIETMWDCME-----------VAGQAMCLIVYMMVMVIGNLVV 948
Query: 1700 LNLFVAVIMDNF 1711
LNLF+A+++ +F
Sbjct: 949 LNLFLALLLSSF 960
Score = 113 bits (282), Expect = 2e-24
Identities = 88/341 (25%), Positives = 162/341 (47%), Gaps = 56/341 (16%)
Query: 1129 SMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDY 1188
+++ LSP + LRR I+ F ++I+ I + I + +P + K ++Y
Sbjct: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPP-------DWTKNVEY 157
Query: 1189 IFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIK 1248
FTG++TFE ++K++ G + + RD WN LDF+V+ FA+ ++ ++ +
Sbjct: 158 TFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVI-----VFAYL-TEFVNLGNVS 211
Query: 1249 SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG-- 1306
+LR RVLR LKTI +P LK + ++ S+K + +++I+ + + +FA+I +QLF G
Sbjct: 212 ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNL 271
Query: 1307 --KFFYCTDESKEL----------ERDCRG--QYLDYEKE--------------EVEAQP 1338
K F + E+ E E D R YL+ K+ E
Sbjct: 272 KHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCV 331
Query: 1339 RQWKKYDFHY---DNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIF 1395
+ + D+ Y D WA L LF + T + W + + ++ A + IF
Sbjct: 332 KIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK----------TYMIF 381
Query: 1396 YVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNE 1436
+VV + F+ +N+ +A++ + ++EQ + E ++ E
Sbjct: 382 FVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELE 422
Score = 101 bits (251), Expect = 1e-20
Identities = 80/383 (20%), Positives = 168/383 (43%), Gaps = 54/383 (14%)
Query: 406 NAEEKSPLDVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTE------ 459
++ E S +D +++ + ++++E E F D C + +++SGK +
Sbjct: 1112 SSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIR 1171
Query: 460 SSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEF 519
+ Y + F FI V++ +++ L ++ + + + L +A+
Sbjct: 1172 KTCYKIVEHSWFESFI-----------VLMILLSSGALAFEDIYIERKKTIKIILEYADK 1220
Query: 520 VFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRA 579
+F +F+ EM LK G ++YF +++ DF ++ S+ +V + I LR
Sbjct: 1221 IFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRT 1280
Query: 580 LRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF---- 635
LR LR + + +R +V +L+ ++ SI+++L + +F ++F+++G+ LF G+F
Sbjct: 1281 LRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECI 1340
Query: 636 ---------------------------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAV 668
N + + NFD L++ Q+ T + W +
Sbjct: 1341 NTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTII 1400
Query: 669 MYHGIES-----QGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEE 723
MY ++S Q ++ YF+V +FG++ LN+F+ + +DN N Q+ +
Sbjct: 1401 MYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNF-NQQKKKLGGQ 1459
Query: 724 EMEEAANQKLALQKAKEVAEVSP 746
++ QK K++ P
Sbjct: 1460 DIFMTEEQKKYYNAMKKLGSKKP 1482
Score = 89.7 bits (221), Expect = 3e-17
Identities = 81/297 (27%), Positives = 137/297 (46%), Gaps = 43/297 (14%)
Query: 1134 SPTNLLRRFCHYIVTMRYF-EVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTG 1192
SP + + C Y + M F ++ I + I L+++ +A E T+ +N L + +FTG
Sbjct: 716 SPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN-VLAIGNLVFTG 774
Query: 1193 VFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRV 1252
+F EMV+K+I + P YF+ WNI D ++V+ +LV + D+ + LR
Sbjct: 775 IFAAEMVLKLI----AMDPYEYFQVGWNIFDSLIVTLSLVELFLA-----DVEGLSVLRS 825
Query: 1253 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCT 1312
R+LR K K P L + + NS+ + N+ +V + +FIFAV+ +QLF + C
Sbjct: 826 FRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 885
Query: 1313 DESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLK 1372
++ DC PR W DF + + L +F V GE W +
Sbjct: 886 ---CKINDDC-------------TLPR-WHMNDFFH-----SFLIVFRVLCGE-WIETMW 922
Query: 1373 HSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSE 1429
++ G M L I Y++ V+ +N+F+AL++ +F + E
Sbjct: 923 DCMEVA--------GQAMCL-IVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEE 970
Score = 84.0 bits (206), Expect = 2e-15
Identities = 79/328 (24%), Positives = 147/328 (44%), Gaps = 55/328 (16%)
Query: 95 PPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT----EPYFIGIFCFEAGIKII 150
P + I I+ N + +A+E H PM+E + F GIF E +K+I
Sbjct: 733 PFVDLAITICIVLNTLFMAMEHH-------PMTEEFKNVLAIGNLVFTGIFAAEMVLKLI 785
Query: 151 ALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFD-LRTLRAVRVLRPLKLVSGIPSL 209
A+ Y + GWN+ D ++V ++ D + L LR+ R+LR KL P+L
Sbjct: 786 AMD----PYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTL 841
Query: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
+++K I ++ L + L+L + +FA++G++ + GK +K C
Sbjct: 842 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKEC---------------- 884
Query: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
+C+ + +C P + + +F + L VF+ + E W + +++ + AG
Sbjct: 885 ------VCKINDDCTL----PRWHMNDF---FHSFLIVFRVLCGE-WIETMWDCMEVAGQ 930
Query: 330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEF------AKERERVENRRAFLKLRRQQQIER 383
+ ++ +++IG+ +LNL L +L F A E + N R ++ I
Sbjct: 931 AMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINY 990
Query: 384 ELNGYLEWIFKA--EEVMLAEEDRNAEE 409
E+I KA ++ ++ E R AE+
Sbjct: 991 VKQTLREFILKAFSKKPKISREIRQAED 1018
Score = 73.9 bits (180), Expect = 2e-12
Identities = 72/316 (22%), Positives = 141/316 (44%), Gaps = 52/316 (16%)
Query: 1135 PTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVF 1194
P N ++ +VT + F++ I+V+I L+ + + E ++ L +++ +F +F
Sbjct: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQH-MTEVLYWINVVFIILF 1547
Query: 1195 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSG---SKGKDINTIKSLR 1251
T E V+K+I L YF WNI DF+VV ++V + + + +R
Sbjct: 1548 TGECVLKLISL-----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIR 1602
Query: 1252 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYC 1311
+ R+ R L+ +K ++ + ++ SL + NI ++ L MFI+A+ + F
Sbjct: 1603 LARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA------ 1656
Query: 1312 TDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVL 1371
Y K+E F+++ +++ LF ++T GW +L
Sbjct: 1657 -----------------YVKKEDGINDM------FNFETFGNSMICLFQITTSAGWDGLL 1693
Query: 1372 KHSVDATYEEQGPS---PGYRME-------LSIFYVVYFVVFPFF-FVNIFVALIIITFQ 1420
+++ + P PG +E + IFY V +++ F VN+++A+I+ F
Sbjct: 1694 APILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFS 1753
Query: 1421 ---EQGDKVMSECSLE 1433
E+ + +SE E
Sbjct: 1754 VATEESTEPLSEDDFE 1769
Score = 67.4 bits (163), Expect = 2e-10
Identities = 81/328 (24%), Positives = 136/328 (41%), Gaps = 76/328 (23%)
Query: 1442 FAISAKP----LTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPY 1497
F +A P L+ + P R S + +V F IM I N + + M + P
Sbjct: 98 FRFNATPALYMLSPFSPLRRISIK-----ILVHSLFSMLIMCTILTNCIFMTM---NNPP 149
Query: 1498 EYELMLKCLNIVFTSMFSMECVLKIIA----FGVLNYFRDAWNVFDFVTVLGSITDILVT 1553
++ K + FT +++ E ++KI+A G + RD WN DFV I+
Sbjct: 150 DWT---KNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVV-------IVFA 199
Query: 1554 EIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1613
+ E N N+S LR FR R +K + ++ ++ +QS K L V +L ++
Sbjct: 200 YLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 259
Query: 1614 AIIGMQVF-GNI-------ALDDD-------TSINRHNNFRTFL-------QALMLLFRS 1651
A+IG+Q+F GN+ +L+++ ++ +FR + AL+ F +
Sbjct: 260 ALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFST 319
Query: 1652 ATGE------------------------AWHEIMLSCLSNQACDE---QANATECGSDFA 1684
+G+ +W + L L Q E Q G +
Sbjct: 320 DSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM 379
Query: 1685 YFYFVSFIFLCSFLMLNLFVAVIMDNFE 1712
F FV IFL SF ++NL +AV+ +E
Sbjct: 380 IF-FVVVIFLGSFYLINLILAVVAMAYE 406
Score = 62.0 bits (149), Expect = 7e-09
Identities = 44/154 (28%), Positives = 77/154 (50%), Gaps = 16/154 (10%)
Query: 484 FYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKM----YGLGPR 539
F +++C + N + + M N P T + E+ F G++ E +K+ + +G
Sbjct: 128 FSMLIMCTILTNCIFMTM---NNPPDWTKNV---EYTFTGIYTFESLVKILARGFCVGEF 181
Query: 540 SYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLV 599
++ R +N DF VIV F + + G+ +S LR R+LR K L+ +V
Sbjct: 182 TFLRDPWNWLDFVVIV---FAYLTEFVNLGN---VSALRTFRVLRALKTISVIPGLKTIV 235
Query: 600 VSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG 633
+L+ S+K + ++ L + VFAL+G+QLF G
Sbjct: 236 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269
Score = 49.3 bits (116), Expect = 4e-05
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 13/121 (10%)
Query: 644 TNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNV 703
T+FDTF A L +F+++T + W + + + G +F+V+ G++ L+N+
Sbjct: 342 TSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKT-----YMIFFVVVIFLGSFYLINL 396
Query: 704 FLAIAV-----DNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQ 758
LA+ N AN +E + E E ++ ++ L+K +E AE +AA + R
Sbjct: 397 ILAVVAMAYEEQNQANIEEAKQKELEFQQMLDR---LKKEQEEAEAIAAAAAEYTSIRRS 453
Query: 759 Q 759
+
Sbjct: 454 R 454
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,715,803
Number of Sequences: 37866
Number of extensions: 5019587
Number of successful extensions: 48586
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 301
Number of HSP's successfully gapped in prelim test: 1237
Number of HSP's that attempted gapping in prelim test: 29817
Number of HSP's gapped (non-prelim): 14163
length of query: 2339
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2220
effective length of database: 13,741,464
effective search space: 30506050080
effective search space used: 30506050080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.