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Search of human proteins with 4502043
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
(468 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 940 0.0
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 940 0.0
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 852 0.0
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 647 0.0
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 647 0.0
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 508 e-144
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 508 e-144
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 502 e-142
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 502 e-142
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 502 e-142
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 141 1e-33
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 136 4e-32
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 136 4e-32
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 130 3e-30
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 127 2e-29
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 127 2e-29
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 127 2e-29
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 127 2e-29
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 124 2e-28
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 122 9e-28
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 120 2e-27
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 117 2e-26
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 112 7e-25
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 108 1e-23
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 89 7e-18
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 81 2e-15
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 71 2e-12
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 71 2e-12
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 71 2e-12
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 50 4e-06
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 940 bits (2430), Expect = 0.0
Identities = 468/468 (100%), Positives = 468/468 (100%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
Query: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
Sbjct: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 940 bits (2430), Expect = 0.0
Identities = 468/468 (100%), Positives = 468/468 (100%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
Query: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
Sbjct: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 852 bits (2201), Expect = 0.0
Identities = 431/468 (92%), Positives = 431/468 (92%), Gaps = 37/468 (7%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54
Query: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
ATQLDSAFIRKEPFGLVLIIAPWNYPLNL
Sbjct: 55 -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83
Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
Sbjct: 84 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143
Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
Sbjct: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203
Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
Sbjct: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263
Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
Sbjct: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
Sbjct: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Sbjct: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 431
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 647 bits (1668), Expect = 0.0
Identities = 322/387 (83%), Positives = 347/387 (89%), Gaps = 2/387 (0%)
Query: 82 MKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSE 141
MKDE NL +LDS FI KEPFGLVLIIAPWNYPLNLTLV LVGALAAG+CVVLKPSE
Sbjct: 1 MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSE 60
Query: 142 ISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAA 201
IS+ EK+LAEVLPQY+DQSCFAVVLGGPQETGQLLEH+ DYIFFTGSPRVGKIVMTAA
Sbjct: 61 ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT 120
Query: 202 KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL 261
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWF YFNAGQTCVAPDYVLCSPEMQERLL
Sbjct: 121 KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL 180
Query: 262 PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVL 321
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQS+ESDRYIAPTVL
Sbjct: 181 PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL 240
Query: 322 VDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQT 381
VDVQE EPVMQEEIFGPILPIVNVQS+DEAI+FINR+EKPLALYAFSNSSQVV ++L +T
Sbjct: 241 VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT 300
Query: 382 SSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNAL 441
SSG F GN+GF +++L S+PFGGVG SGMGRYHGKF+FDTFSHHR CLL G+EKL +
Sbjct: 301 SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI 360
Query: 442 RYPPQSPRRLRMLLVAMEAQGCSCTLL 468
YPP + ++L M +Q SCTLL
Sbjct: 361 HYPPYTDWNQQLLRWGMGSQ--SCTLL 385
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 647 bits (1668), Expect = 0.0
Identities = 322/387 (83%), Positives = 347/387 (89%), Gaps = 2/387 (0%)
Query: 82 MKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSE 141
MKDE NL +LDS FI KEPFGLVLIIAPWNYPLNLTLV LVGALAAG+CVVLKPSE
Sbjct: 1 MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSE 60
Query: 142 ISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAA 201
IS+ EK+LAEVLPQY+DQSCFAVVLGGPQETGQLLEH+ DYIFFTGSPRVGKIVMTAA
Sbjct: 61 ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT 120
Query: 202 KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL 261
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWF YFNAGQTCVAPDYVLCSPEMQERLL
Sbjct: 121 KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL 180
Query: 262 PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVL 321
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQS+ESDRYIAPTVL
Sbjct: 181 PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL 240
Query: 322 VDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQT 381
VDVQE EPVMQEEIFGPILPIVNVQS+DEAI+FINR+EKPLALYAFSNSSQVV ++L +T
Sbjct: 241 VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT 300
Query: 382 SSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNAL 441
SSG F GN+GF +++L S+PFGGVG SGMGRYHGKF+FDTFSHHR CLL G+EKL +
Sbjct: 301 SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI 360
Query: 442 RYPPQSPRRLRMLLVAMEAQGCSCTLL 468
YPP + ++L M +Q SCTLL
Sbjct: 361 HYPPYTDWNQQLLRWGMGSQ--SCTLL 385
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 508 bits (1308), Expect = e-144
Identities = 245/444 (55%), Positives = 324/444 (72%)
Query: 8 LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAIS 67
+RR+R+AF +GR+RP FR QL+ L R +QE ++ + A+A DL KS F EV
Sbjct: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
Query: 68 QGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 127
GE+ L NL W+ + V KN+ T LD A+I+ +P G+VLII WNYP LT+ PL+G
Sbjct: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
Query: 128 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 187
A+AAGN V++KPSE+S+N KILA++LPQY+DQ + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
Query: 188 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 247
G+ VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD V R+ W +Y N GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
Query: 248 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 307
DY+LC +Q +++ ++ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
Query: 308 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 367
++DE+ RYIAPTVL DV VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
Query: 368 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 427
S++ +++KR++ +TSSGG GND MH TL S PFGGVG+SGMG YHGK SFDTFSH R
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
Query: 428 CLLRSPGMEKLNALRYPPQSPRRL 451
CLL+S E N LRYPP S ++
Sbjct: 425 CLLKSLKREGANKLRYPPNSQSKV 448
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 508 bits (1308), Expect = e-144
Identities = 245/444 (55%), Positives = 324/444 (72%)
Query: 8 LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAIS 67
+RR+R+AF +GR+RP FR QL+ L R +QE ++ + A+A DL KS F EV
Sbjct: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
Query: 68 QGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 127
GE+ L NL W+ + V KN+ T LD A+I+ +P G+VLII WNYP LT+ PL+G
Sbjct: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
Query: 128 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 187
A+AAGN V++KPSE+S+N KILA++LPQY+DQ + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
Query: 188 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 247
G+ VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD V R+ W +Y N GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
Query: 248 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 307
DY+LC +Q +++ ++ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
Query: 308 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 367
++DE+ RYIAPTVL DV VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
Query: 368 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 427
S++ +++KR++ +TSSGG GND MH TL S PFGGVG+SGMG YHGK SFDTFSH R
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
Query: 428 CLLRSPGMEKLNALRYPPQSPRRL 451
CLL+S E N LRYPP S ++
Sbjct: 425 CLLKSLKREGANKLRYPPNSQSKV 448
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 502 bits (1292), Expect = e-142
Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK+ + +
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
EV E+ ++ L W DE V K TQ D +I EP G+VL+I WNYP NL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 502 bits (1292), Expect = e-142
Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK+ + +
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
EV E+ ++ L W DE V K TQ D +I EP G+VL+I WNYP NL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 502 bits (1292), Expect = e-142
Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK+ + +
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
EV E+ ++ L W DE V K TQ D +I EP G+VL+I WNYP NL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 141 bits (356), Expect = 1e-33
Identities = 105/344 (30%), Positives = 166/344 (48%), Gaps = 13/344 (3%)
Query: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
F R EP G+ I PWN+PL + + L AL GN +VLKP+E + L ++ +
Sbjct: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
Query: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
+V G GP + H + + I FTGS VGK+V AA++ +L VTLELGGK
Sbjct: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
Query: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEM-QERLLPALQSTITRFYG 273
NPC V + D +FN GQ C A V ++ E + +++ R G
Sbjct: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
Query: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
D G I+QKQF ++ L+ G ++ GG + ++ +I PTV +V +
Sbjct: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
Query: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
+ +EEIFGP+ PI+ +S++E I+ N + L F+ + ++ + SG
Sbjct: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
Query: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLR 431
N + A PFGG SG GR G+++ ++ + ++
Sbjct: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 136 bits (343), Expect = 4e-32
Identities = 100/341 (29%), Positives = 155/341 (45%), Gaps = 19/341 (5%)
Query: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
+ R+EP G+ + I WNYP + ALA GN +V KPS + +LAE+ +
Sbjct: 165 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 224
Query: 158 VDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELGGKN 215
V F VV GG TGQ L D + FTGS G +M +AK + PVTLELGGK+
Sbjct: 225 VPPGLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 283
Query: 216 PCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YGD 274
P + +CD + GQ C V E+ ++ + R GD
Sbjct: 284 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 343
Query: 275 DPQSSPNLGRIINQKQFQRLRALLGC-----GRVAIGGQ-------SDESDRYIAPTVLV 322
+G +IN+ +R+ + +V GG + Y+ P VL
Sbjct: 344 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 403
Query: 323 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 382
+ ++ ++EEIFGP++ I++ + E +E N LA F+ Q RV+ +
Sbjct: 404 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 463
Query: 383 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 423
+G N+ +++ LPFGG SG GR +G+ + + +S
Sbjct: 464 AGTCFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYS 502
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 136 bits (343), Expect = 4e-32
Identities = 120/450 (26%), Positives = 210/450 (46%), Gaps = 44/450 (9%)
Query: 2 DPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEV 61
D + ++ REAF + +R + R+ L + L+++ + A ++D K+ +
Sbjct: 45 DEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALART 104
Query: 62 SEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSA----FIRKEPFGLVLIIAPWNYP 117
++ S ++N R + + TQ+D + + P G+ +I+PWN P
Sbjct: 105 MDIPRS-------VQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLP 157
Query: 118 LNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQ 175
L L + A+AAGN V+ KPSE++ +L ++L + V +V G GP+
Sbjct: 158 LYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEA 217
Query: 176 LLEH-RFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVD-----DNCDPQTVA 229
L+ H I FTGS + + +A H ++LELGGKNP + D C P TV
Sbjct: 218 LVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVR 277
Query: 230 NRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSP--NLGRIIN 287
+ A N G+ C+ + + L TR + S P ++G +I+
Sbjct: 278 SSFA-----NQGEICLCTSRIFVQKSIYSEFLKRFVEA-TRKWKVGIPSDPLVSIGALIS 331
Query: 288 QKQFQRLR----------ALLGCG----RVAIGGQSDESDRYIAPTVLVDVQEMEPVMQE 333
+ +++R A + CG ++++ + +++ ++ PTV+ D+++ M E
Sbjct: 332 KAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPAR-NQAGYFMLPTVITDIKDESCCMTE 390
Query: 334 EIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFM 393
EIFGP+ +V S +E IE N + LA +S++ V RV + SG N +
Sbjct: 391 EIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLI 450
Query: 394 HMTLASLPFGGVGASGMGRYHGKFSFDTFS 423
+LPFGG+ +SG+GR K S+D F+
Sbjct: 451 RE--LNLPFGGMKSSGIGREGAKDSYDFFT 478
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 130 bits (327), Expect = 3e-30
Identities = 100/340 (29%), Positives = 162/340 (47%), Gaps = 18/340 (5%)
Query: 98 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
A + K+P G+ +I PWN+P + + ALAAG VV+KP+E + LAE+ Q
Sbjct: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247
Query: 158 -VDQSCFAVV---LGGPQETGQLL--EHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLEL 211
+ + V+ +E G+ + + I FTGS GKI++ AA + V++EL
Sbjct: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307
Query: 212 GGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITR 270
GG P V D+ + Q VA +A ++ N GQTCV + L + + + A + +
Sbjct: 308 GGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKK 366
Query: 271 --FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSDE-SDRYIAPTVLV 322
G+ + G +IN+K +++ A+ V GG+ + + PT+L
Sbjct: 367 NLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLC 426
Query: 323 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 382
+V + EE FGP+ P++ + +EAI N + LA Y +S + RV Q
Sbjct: 427 NVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLE 486
Query: 383 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
G N+G ++ PFGGV SG+GR K+ D +
Sbjct: 487 VGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 524
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 127 bits (320), Expect = 2e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
Query: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
Query: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 273
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
Query: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
Query: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374
Query: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 375 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 418
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 127 bits (320), Expect = 2e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
Query: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
Query: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 273
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
Query: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
Query: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470
Query: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 471 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 514
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 127 bits (320), Expect = 2e-29
Identities = 103/353 (29%), Positives = 163/353 (46%), Gaps = 31/353 (8%)
Query: 98 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
A + K+P G+ +I PWN+P + + ALAAG VV+KP+E + LAEV +
Sbjct: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGF 247
Query: 158 ---VDQSCFAVVLGGP--------------QETGQLL--EHRFDYIFFTGSPRVGKIVMT 198
+D A G P +E G+ + + I FTGS GKI++
Sbjct: 248 LLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 307
Query: 199 AAAKHLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQ 257
AA + V++ELGG P V D+ + Q VA +A ++ N GQTCV + L +
Sbjct: 308 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIH 366
Query: 258 ERLLPALQSTITR--FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSD 310
+ + A + + G+ + G +IN+K +++ A+ V GG+
Sbjct: 367 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 426
Query: 311 E-SDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSN 369
+ + PT+L +V + EE FGP+ P++ + +EAI N + LA Y +S
Sbjct: 427 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 486
Query: 370 SSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
+ RV Q G N+G ++ PFGGV SG+GR K+ D +
Sbjct: 487 DPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 537
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 127 bits (319), Expect = 2e-29
Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 13/347 (3%)
Query: 98 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
++ R EP G+ I PWN+PL + L ALA GN VV+K +E + +A ++ +
Sbjct: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228
Query: 158 -VDQSCFAVVLG-GPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAA-AKHLTPVTLELGG 213
+V G GP + H D + FTGS +G+++ AA + +L VTLELGG
Sbjct: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288
Query: 214 KNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFY 272
K+P + + D + + +FN GQ C A ++ + + ++ +R
Sbjct: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348
Query: 273 GDDPQSSPNLGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQE 326
G+ S G +++ QF+++ + G+ + GG + + +I PTV DVQ+
Sbjct: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408
Query: 327 MEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGF 386
+ +EEIFGP++ I+ ++++E + N LA F+ + +G
Sbjct: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
Query: 387 CGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
N + A PFGG SG GR G++ ++ + ++ P
Sbjct: 469 WVN--CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVP 513
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 124 bits (310), Expect = 2e-28
Identities = 116/440 (26%), Positives = 180/440 (40%), Gaps = 20/440 (4%)
Query: 8 LRRLREAFHAG---RTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEV 64
++ REAF G R A R L L ++ ++ L D K ES
Sbjct: 80 VKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQES----Y 135
Query: 65 AISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVP 124
A+ EV R W F R EP G+ I PWN+PL +
Sbjct: 136 ALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWK 195
Query: 125 LVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQLLEH-RF 181
L ALA GN VV+K +E + LA ++ + ++ G GP + +H
Sbjct: 196 LAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDV 255
Query: 182 DYIFFTGSPRVGKIVMTAAA-KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
D + FTGS VG ++ AA +L VTLELGGK+P V + D + + +FN
Sbjct: 256 DKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNM 315
Query: 241 GQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLG 299
GQ C A + L ++ R G+ + G ++++QF+R+ +
Sbjct: 316 GQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQ 375
Query: 300 CG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIE 353
G ++ GG+ E +I PTV VQ+ + +EEIFGP+ P+ + ++E +E
Sbjct: 376 LGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVE 435
Query: 354 FINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRY 413
N LA F+ +G N ++ PFGG SG GR
Sbjct: 436 RANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNT--YNIVTCHTPFGGFKESGNGRE 493
Query: 414 HGKFSFDTFSHHRACLLRSP 433
G+ ++ + ++ P
Sbjct: 494 LGEDGLKAYTEVKTVTIKVP 513
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 122 bits (305), Expect = 9e-28
Identities = 112/436 (25%), Positives = 192/436 (44%), Gaps = 32/436 (7%)
Query: 8 LRRLREAFHAG---RTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEV 64
++ R+AF G RT A R L L ++ ++ LL + + K + ++++
Sbjct: 64 VKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDL 123
Query: 65 AISQGEVTLALRNLRAW---MKDERVPKNLATQLDSAFI---RKEPFGLVLIIAPWNYPL 118
A LR W ++ +P +D F R EP G+ I PWN+PL
Sbjct: 124 A----GCIKTLRYCAGWADKIQGRTIP------IDGNFFTYTRHEPIGVCGQIIPWNFPL 173
Query: 119 NLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQL 176
+ + + AL+ GN VV+KP+E + +A ++ + +V G GP +
Sbjct: 174 VMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAI 233
Query: 177 LEHR-FDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPCYVDDNCDPQTVANRVAW 234
H D + FTGS VGK++ AA K +L VTLELGGK+PC V + D
Sbjct: 234 SSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHH 293
Query: 235 FRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQS-SPNLGRIINQKQFQR 293
+++ GQ C+A + + + + ++ +P + G I+++Q+ +
Sbjct: 294 GVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDK 353
Query: 294 LRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS 347
+ L+ G+ GG ++ PTV +V + + +EEIFGP+ I+ +S
Sbjct: 354 ILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKS 413
Query: 348 LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGA 407
LD+ I+ N L+ F+ + + +G N + A PFGG
Sbjct: 414 LDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKM 471
Query: 408 SGMGRYHGKFSFDTFS 423
SG GR G++ F ++
Sbjct: 472 SGNGRELGEYGFHEYT 487
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 120 bits (302), Expect = 2e-27
Identities = 114/430 (26%), Positives = 186/430 (43%), Gaps = 25/430 (5%)
Query: 12 REAFHAGR--TRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQG 69
++AF G A R + L L+EN++ L A + L A + + I
Sbjct: 490 KDAFENGEWGRMNARERGRLMYRLADLLEENQEEL--ATIEALDSGAVYTLALKTHIGMS 547
Query: 70 EVTLALRNLRAW---MKDERVPKNLAT-QLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPL 125
T R W ++ +P N A + F +KEP G+ II PWNYPL +
Sbjct: 548 VQTF--RYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKS 605
Query: 126 VGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVDQSCFAVVLGGPQETGQLLEHRFDY- 183
LAAGN +VLKP++++ AE+ + + ++ G GQ L D
Sbjct: 606 AACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIR 665
Query: 184 -IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAG 241
+ FTGS +GK +M + A +L V+LELGGK+P + ++C+ +FN G
Sbjct: 666 KLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKG 725
Query: 242 QTCVAPDYVLCSPEMQERLLPALQSTITRF-YGDDPQSSPNLGRIINQKQFQRLRALL-- 298
+ C+A + + + + + I + GD S + G ++ ++L
Sbjct: 726 ENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCET 785
Query: 299 ----GCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS--LDEAI 352
G V G Q ++ PTV DV++ + +EE FGPI+ I Q+ +D +
Sbjct: 786 GVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVL 845
Query: 353 EFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGR 412
+ N E LA F+ V + +G N + T + PFGGV SG G+
Sbjct: 846 QRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINT--YNKTDVAAPFGGVKQSGFGK 903
Query: 413 YHGKFSFDTF 422
G+ + + +
Sbjct: 904 DLGEEALNEY 913
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 117 bits (294), Expect = 2e-26
Identities = 110/434 (25%), Positives = 185/434 (42%), Gaps = 66/434 (15%)
Query: 2 DPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEV 61
D + ++ REAF + +R + R+ L + L+++ + A ++D K+ +
Sbjct: 45 DEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALART 104
Query: 62 SEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSA----FIRKEPFGLVLIIAPWNYP 117
++ S ++N R + + TQ+D + + P G+ +I+PWN P
Sbjct: 105 MDIPRS-------VQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLP 157
Query: 118 LNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQ 175
L L + A+AAGN V+ KPSE++ +L ++L + V +V G GP+
Sbjct: 158 LYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEA 217
Query: 176 LLEH-RFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVD-----DNCDPQTVA 229
L+ H I FTGS + + +A H ++LELGGKNP + D C P TV
Sbjct: 218 LVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVR 277
Query: 230 NRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQK 289
+ A + + C + + LPA
Sbjct: 278 SSFANQVRSYVKRALAEGAQIWCGEGVDKLSLPA-------------------------- 311
Query: 290 QFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLD 349
+++ ++ PTV+ D+++ M EEIFGP+ +V S +
Sbjct: 312 -------------------RNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEE 352
Query: 350 EAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
E IE N + LA +S++ V RV + SG N + +LPFGG+ +SG
Sbjct: 353 EVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRE--LNLPFGGMKSSG 410
Query: 410 MGRYHGKFSFDTFS 423
+GR K S+D F+
Sbjct: 411 IGREGAKDSYDFFT 424
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 112 bits (280), Expect = 7e-25
Identities = 91/335 (27%), Positives = 145/335 (43%), Gaps = 15/335 (4%)
Query: 101 RKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVD 159
RKEP G+ II PWNYPL + LAAGN VV+KP++++ AE+ L +
Sbjct: 560 RKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP 619
Query: 160 QSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNP 216
+ V+ G GQ L D I FTGS VGK +M + A ++ V+LELGGK+P
Sbjct: 620 KGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSP 679
Query: 217 CYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDP 276
+ +CD +FN G+ C+A + + + + + + + +P
Sbjct: 680 LIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNP 739
Query: 277 QS-------SPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEP 329
+ ++ ++ + G V G Q + PTV DV++
Sbjct: 740 LDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMF 799
Query: 330 VMQEEIFGPILPIVNVQ--SLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
+ +EE FGP++ I LD + N E LA F+ V + +G
Sbjct: 800 IAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVF 859
Query: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
N + T + PFGG SG G+ G+ + + +
Sbjct: 860 VNT--YNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 108 bits (270), Expect = 1e-23
Identities = 89/343 (25%), Positives = 145/343 (42%), Gaps = 45/343 (13%)
Query: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYV 158
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
Query: 159 DQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPC 217
VGK++ AA + +L VTLELGGK+P
Sbjct: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
Query: 218 YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDP 276
+ + D + +FN GQ C A + + E + +++ R G
Sbjct: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
Query: 277 QSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPV 330
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V + +
Sbjct: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
Query: 331 MQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND 390
+EEIFGP+ I+ +++DE IE N + L F+N V + +G N
Sbjct: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434
Query: 391 GFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
+ A PFGG SG GR G+F +S + ++ P
Sbjct: 435 -CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 476
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 89.4 bits (220), Expect = 7e-18
Identities = 64/265 (24%), Positives = 121/265 (45%), Gaps = 12/265 (4%)
Query: 104 PFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSC 162
P G+ IAP+N+P + L A+ GN ++KPSE +LA++L
Sbjct: 175 PLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGT 234
Query: 163 FAVVLGGPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDD 221
++ G + + +H I F GS + G+ + ++H V +G KN V
Sbjct: 235 LNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMP 294
Query: 222 NCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPN 281
+ + + N++ + AGQ C+A + E ++ L ++ Q +
Sbjct: 295 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGAD 354
Query: 282 LGRIINQKQFQRLRALLGCGR-----VAIGGQSD-----ESDRYIAPTVLVDVQEMEPVM 331
LG +I + +R+ L+ G + + G+ E+ ++ PT++ +V+
Sbjct: 355 LGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCY 414
Query: 332 QEEIFGPILPIVNVQSLDEAIEFIN 356
+EEIFGP+L ++ ++LDEAI+ +N
Sbjct: 415 KEEIFGPVLVVLETETLDEAIQIVN 439
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 80.9 bits (198), Expect = 2e-15
Identities = 108/450 (24%), Positives = 180/450 (40%), Gaps = 40/450 (8%)
Query: 6 DTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFES--EVSE 63
+T+++ REA+ PA R ++ +G L+E Q+L ++ ++ K E EV E
Sbjct: 90 ETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQE 149
Query: 64 -VAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTL 122
V I V L+ + ER L Q + P GLV II +N+P+ +
Sbjct: 150 YVDICDYAVGLSRMIGGPILPSERSGHALIEQWN-------PVGLVGIITAFNFPVAVYG 202
Query: 123 VPLVGALAAGNCVVLK----PSEISKNVEKILAEVLP--QYVDQSCFAVVLGGPQETGQL 176
A+ GN + K S IS V KI+A+VL + C G T
Sbjct: 203 WNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMA 262
Query: 177 LEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFR 236
+ R + + FTGS +VGK V + LELGG N ++ D V +
Sbjct: 263 KDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAA 322
Query: 237 YFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRA 296
AGQ C + + + ++ L+ + +P L ++ K Q +
Sbjct: 323 VGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTK--QAVSM 380
Query: 297 LLGC--------GRVAIGGQ-SDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS 347
LG G V GG+ D Y+ PT++ + + E F PIL + ++
Sbjct: 381 FLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKN 440
Query: 348 LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND-GFMHMTLASL------ 400
+E + N ++ L+ F+ + R L G G+D G +++ + +
Sbjct: 441 EEEVFAWNNEVKQGLSSSIFTKDLGRIFRWL------GPKGSDCGIVNVNIPTSGAEIGG 494
Query: 401 PFGGVGASGMGRYHGKFSFDTFSHHRACLL 430
FGG +G GR G ++ + C +
Sbjct: 495 AFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
Query: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
Query: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
Query: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
Query: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493
Query: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
+ + ++G F ND + PFGG ASG
Sbjct: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 142 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 197
Query: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 198 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 253
Query: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 254 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 313
Query: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 314 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 373
Query: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 374 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 433
Query: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
+ + ++G F ND + PFGG ASG
Sbjct: 434 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 467
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
Query: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
Query: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
Query: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
Query: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493
Query: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
+ + ++G F ND + PFGG ASG
Sbjct: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 50.1 bits (118), Expect = 4e-06
Identities = 55/195 (28%), Positives = 83/195 (42%), Gaps = 20/195 (10%)
Query: 26 RAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAWMKDE 85
RAA L L L+ K L S E + +E+ ++ EV L+ R LRAW
Sbjct: 537 RAALLWALAAALERRKSTL---------ASRLERQGAELKAAEAEVELSARRLRAW--GA 585
Query: 86 RVPKNLATQLDSAFIR------KEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKP 139
RV T L A +R +EP G++ ++ P +PL + L ALA GN VV+ P
Sbjct: 586 RVQAQGHT-LQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVP 644
Query: 140 SEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM 197
S + + + + VV G + L D +++ GS + + V
Sbjct: 645 SAACPLLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVE 704
Query: 198 TAAAKHLTPVTLELG 212
A+A +L PV G
Sbjct: 705 WASAGNLKPVWASRG 719
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,783,283
Number of Sequences: 37866
Number of extensions: 788514
Number of successful extensions: 1720
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1625
Number of HSP's gapped (non-prelim): 40
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.