Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 4502043

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
         (468 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]      940   0.0  
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]        940   0.0  
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]       852   0.0  
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]                 647   0.0  
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]                 647   0.0  
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]        508   e-144
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]       508   e-144
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]                 502   e-142
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]                502   e-142
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]                502   e-142
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]                141   1e-33
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]                136   4e-32
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]       136   4e-32
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ...   130   3e-30
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]       127   2e-29
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]       127   2e-29
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo...   127   2e-29
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho...   127   2e-29
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]       124   2e-28
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]                 122   9e-28
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa...   120   2e-27
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]       117   2e-26
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap...   112   7e-25
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]       108   1e-23
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]        89   7e-18
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa...    81   2e-15
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...    71   2e-12
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]       71   2e-12
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...    71   2e-12
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform...    50   4e-06

>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score =  940 bits (2430), Expect = 0.0
 Identities = 468/468 (100%), Positives = 468/468 (100%)

Query: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
           MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
Sbjct: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60

Query: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
           VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
Sbjct: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120

Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
           TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180

Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
           FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240

Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
           GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300

Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
           GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360

Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
           PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420

Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
           TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468


>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score =  940 bits (2430), Expect = 0.0
 Identities = 468/468 (100%), Positives = 468/468 (100%)

Query: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
           MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
Sbjct: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60

Query: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
           VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
Sbjct: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120

Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
           TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180

Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
           FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240

Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
           GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300

Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
           GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360

Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
           PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420

Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
           TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468


>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
          Length = 431

 Score =  852 bits (2201), Expect = 0.0
 Identities = 431/468 (92%), Positives = 431/468 (92%), Gaps = 37/468 (7%)

Query: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
           MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK      
Sbjct: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54

Query: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
                                          ATQLDSAFIRKEPFGLVLIIAPWNYPLNL
Sbjct: 55  -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83

Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
           TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
Sbjct: 84  TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143

Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
           FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
Sbjct: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203

Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
           GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
Sbjct: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263

Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
           GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
Sbjct: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323

Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
           PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
Sbjct: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383

Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
           TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Sbjct: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 431


>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score =  647 bits (1668), Expect = 0.0
 Identities = 322/387 (83%), Positives = 347/387 (89%), Gaps = 2/387 (0%)

Query: 82  MKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSE 141
           MKDE    NL  +LDS FI KEPFGLVLIIAPWNYPLNLTLV LVGALAAG+CVVLKPSE
Sbjct: 1   MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSE 60

Query: 142 ISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAA 201
           IS+  EK+LAEVLPQY+DQSCFAVVLGGPQETGQLLEH+ DYIFFTGSPRVGKIVMTAA 
Sbjct: 61  ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT 120

Query: 202 KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL 261
           KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWF YFNAGQTCVAPDYVLCSPEMQERLL
Sbjct: 121 KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL 180

Query: 262 PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVL 321
           PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQS+ESDRYIAPTVL
Sbjct: 181 PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL 240

Query: 322 VDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQT 381
           VDVQE EPVMQEEIFGPILPIVNVQS+DEAI+FINR+EKPLALYAFSNSSQVV ++L +T
Sbjct: 241 VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT 300

Query: 382 SSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNAL 441
           SSG F GN+GF +++L S+PFGGVG SGMGRYHGKF+FDTFSHHR CLL   G+EKL  +
Sbjct: 301 SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI 360

Query: 442 RYPPQSPRRLRMLLVAMEAQGCSCTLL 468
            YPP +    ++L   M +Q  SCTLL
Sbjct: 361 HYPPYTDWNQQLLRWGMGSQ--SCTLL 385


>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score =  647 bits (1668), Expect = 0.0
 Identities = 322/387 (83%), Positives = 347/387 (89%), Gaps = 2/387 (0%)

Query: 82  MKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSE 141
           MKDE    NL  +LDS FI KEPFGLVLIIAPWNYPLNLTLV LVGALAAG+CVVLKPSE
Sbjct: 1   MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSE 60

Query: 142 ISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAA 201
           IS+  EK+LAEVLPQY+DQSCFAVVLGGPQETGQLLEH+ DYIFFTGSPRVGKIVMTAA 
Sbjct: 61  ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT 120

Query: 202 KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL 261
           KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWF YFNAGQTCVAPDYVLCSPEMQERLL
Sbjct: 121 KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL 180

Query: 262 PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVL 321
           PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQS+ESDRYIAPTVL
Sbjct: 181 PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL 240

Query: 322 VDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQT 381
           VDVQE EPVMQEEIFGPILPIVNVQS+DEAI+FINR+EKPLALYAFSNSSQVV ++L +T
Sbjct: 241 VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT 300

Query: 382 SSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNAL 441
           SSG F GN+GF +++L S+PFGGVG SGMGRYHGKF+FDTFSHHR CLL   G+EKL  +
Sbjct: 301 SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI 360

Query: 442 RYPPQSPRRLRMLLVAMEAQGCSCTLL 468
            YPP +    ++L   M +Q  SCTLL
Sbjct: 361 HYPPYTDWNQQLLRWGMGSQ--SCTLL 385


>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
          Length = 485

 Score =  508 bits (1308), Expect = e-144
 Identities = 245/444 (55%), Positives = 324/444 (72%)

Query: 8   LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAIS 67
           +RR+R+AF +GR+RP  FR  QL+ L R +QE ++ +  A+A DL KS F     EV   
Sbjct: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64

Query: 68  QGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 127
            GE+   L NL  W+  + V KN+ T LD A+I+ +P G+VLII  WNYP  LT+ PL+G
Sbjct: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124

Query: 128 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 187
           A+AAGN V++KPSE+S+N  KILA++LPQY+DQ  + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184

Query: 188 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 247
           G+  VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD   V  R+ W +Y N GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244

Query: 248 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 307
           DY+LC   +Q +++  ++ T+  FYG++ + SP+  RIIN + F+R+ +LL   ++A GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304

Query: 308 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 367
           ++DE+ RYIAPTVL DV     VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364

Query: 368 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 427
           S++ +++KR++ +TSSGG  GND  MH TL S PFGGVG+SGMG YHGK SFDTFSH R 
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424

Query: 428 CLLRSPGMEKLNALRYPPQSPRRL 451
           CLL+S   E  N LRYPP S  ++
Sbjct: 425 CLLKSLKREGANKLRYPPNSQSKV 448


>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  508 bits (1308), Expect = e-144
 Identities = 245/444 (55%), Positives = 324/444 (72%)

Query: 8   LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAIS 67
           +RR+R+AF +GR+RP  FR  QL+ L R +QE ++ +  A+A DL KS F     EV   
Sbjct: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64

Query: 68  QGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 127
            GE+   L NL  W+  + V KN+ T LD A+I+ +P G+VLII  WNYP  LT+ PL+G
Sbjct: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124

Query: 128 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 187
           A+AAGN V++KPSE+S+N  KILA++LPQY+DQ  + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184

Query: 188 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 247
           G+  VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD   V  R+ W +Y N GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244

Query: 248 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 307
           DY+LC   +Q +++  ++ T+  FYG++ + SP+  RIIN + F+R+ +LL   ++A GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304

Query: 308 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 367
           ++DE+ RYIAPTVL DV     VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364

Query: 368 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 427
           S++ +++KR++ +TSSGG  GND  MH TL S PFGGVG+SGMG YHGK SFDTFSH R 
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424

Query: 428 CLLRSPGMEKLNALRYPPQSPRRL 451
           CLL+S   E  N LRYPP S  ++
Sbjct: 425 CLLKSLKREGANKLRYPPNSQSKV 448


>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  502 bits (1292), Expect = e-142
 Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)

Query: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
           M  + + ++R R AF +GRTRP +FR  QL+ L R +QE +Q L  ALA DLHK+ + + 
Sbjct: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
             EV     E+   ++ L  W  DE V K   TQ D  +I  EP G+VL+I  WNYP NL
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
           T+ P+VGA+AAGN VVLKPSE+S+N+  +LA ++PQY+D+  + V+ GG  ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180

Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
           FD+I +TGS  VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD      R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
           GQTCVAPDY+LC P +Q +++  L+ ++  FYG+D + S + GRII+ + FQR+  L+  
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300

Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
            +VA GG  D + RYIAPT+L DV    PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360

Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
           PLALY FS++ +V+K+++ +TSSGG   ND  +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420

Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451
           TFSH R+CL+R    ++   +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450


>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  502 bits (1292), Expect = e-142
 Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)

Query: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
           M  + + ++R R AF +GRTRP +FR  QL+ L R +QE +Q L  ALA DLHK+ + + 
Sbjct: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
             EV     E+   ++ L  W  DE V K   TQ D  +I  EP G+VL+I  WNYP NL
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
           T+ P+VGA+AAGN VVLKPSE+S+N+  +LA ++PQY+D+  + V+ GG  ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180

Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
           FD+I +TGS  VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD      R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
           GQTCVAPDY+LC P +Q +++  L+ ++  FYG+D + S + GRII+ + FQR+  L+  
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300

Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
            +VA GG  D + RYIAPT+L DV    PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360

Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
           PLALY FS++ +V+K+++ +TSSGG   ND  +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420

Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451
           TFSH R+CL+R    ++   +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450


>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  502 bits (1292), Expect = e-142
 Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)

Query: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
           M  + + ++R R AF +GRTRP +FR  QL+ L R +QE +Q L  ALA DLHK+ + + 
Sbjct: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
             EV     E+   ++ L  W  DE V K   TQ D  +I  EP G+VL+I  WNYP NL
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
           T+ P+VGA+AAGN VVLKPSE+S+N+  +LA ++PQY+D+  + V+ GG  ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180

Query: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
           FD+I +TGS  VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD      R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
           GQTCVAPDY+LC P +Q +++  L+ ++  FYG+D + S + GRII+ + FQR+  L+  
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300

Query: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
            +VA GG  D + RYIAPT+L DV    PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360

Query: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
           PLALY FS++ +V+K+++ +TSSGG   ND  +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420

Query: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451
           TFSH R+CL+R    ++   +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450


>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
          Length = 512

 Score =  141 bits (356), Expect = 1e-33
 Identities = 105/344 (30%), Positives = 166/344 (48%), Gaps = 13/344 (3%)

Query: 99  FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
           F R EP G+   I PWN+PL + +  L  AL  GN +VLKP+E +      L  ++ +  
Sbjct: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224

Query: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
                  +V G GP     +  H + + I FTGS  VGK+V  AA++ +L  VTLELGGK
Sbjct: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284

Query: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEM-QERLLPALQSTITRFYG 273
           NPC V  + D            +FN GQ C A   V    ++  E +  +++    R  G
Sbjct: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344

Query: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
           D        G  I+QKQF ++  L+  G     ++  GG + ++   +I PTV  +V + 
Sbjct: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404

Query: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
             + +EEIFGP+ PI+  +S++E I+  N  +  L    F+ +     ++ +   SG   
Sbjct: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464

Query: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLR 431
            N    +   A  PFGG   SG GR  G+++   ++  +   ++
Sbjct: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506


>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
          Length = 518

 Score =  136 bits (343), Expect = 4e-32
 Identities = 100/341 (29%), Positives = 155/341 (45%), Gaps = 19/341 (5%)

Query: 99  FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
           + R+EP G+ + I  WNYP  +       ALA GN +V KPS  +     +LAE+  +  
Sbjct: 165 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 224

Query: 158 VDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELGGKN 215
           V    F VV GG   TGQ L    D   + FTGS   G  +M  +AK + PVTLELGGK+
Sbjct: 225 VPPGLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 283

Query: 216 PCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YGD 274
           P  +  +CD            +   GQ C     V    E+ ++    +     R   GD
Sbjct: 284 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 343

Query: 275 DPQSSPNLGRIINQKQFQRLRALLGC-----GRVAIGGQ-------SDESDRYIAPTVLV 322
                  +G +IN+   +R+   +        +V  GG          +   Y+ P VL 
Sbjct: 344 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 403

Query: 323 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 382
           + ++    ++EEIFGP++ I++  +  E +E  N     LA   F+   Q   RV+ +  
Sbjct: 404 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 463

Query: 383 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 423
           +G    N+   +++   LPFGG   SG GR +G+ + + +S
Sbjct: 464 AGTCFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYS 502


>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
          Length = 487

 Score =  136 bits (343), Expect = 4e-32
 Identities = 120/450 (26%), Positives = 210/450 (46%), Gaps = 44/450 (9%)

Query: 2   DPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEV 61
           D +   ++  REAF +  +R  + R+  L  +   L+++ +    A ++D  K+   +  
Sbjct: 45  DEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALART 104

Query: 62  SEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSA----FIRKEPFGLVLIIAPWNYP 117
            ++  S       ++N R +        +  TQ+D      +  + P G+  +I+PWN P
Sbjct: 105 MDIPRS-------VQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLP 157

Query: 118 LNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQ 175
           L L    +  A+AAGN V+ KPSE++     +L ++L +  V      +V G GP+    
Sbjct: 158 LYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEA 217

Query: 176 LLEH-RFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVD-----DNCDPQTVA 229
           L+ H     I FTGS    + +   +A H   ++LELGGKNP  +      D C P TV 
Sbjct: 218 LVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVR 277

Query: 230 NRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSP--NLGRIIN 287
           +  A     N G+ C+    +     +    L       TR +     S P  ++G +I+
Sbjct: 278 SSFA-----NQGEICLCTSRIFVQKSIYSEFLKRFVEA-TRKWKVGIPSDPLVSIGALIS 331

Query: 288 QKQFQRLR----------ALLGCG----RVAIGGQSDESDRYIAPTVLVDVQEMEPVMQE 333
           +   +++R          A + CG    ++++  + +++  ++ PTV+ D+++    M E
Sbjct: 332 KAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPAR-NQAGYFMLPTVITDIKDESCCMTE 390

Query: 334 EIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFM 393
           EIFGP+  +V   S +E IE  N  +  LA   +S++   V RV  +  SG    N   +
Sbjct: 391 EIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLI 450

Query: 394 HMTLASLPFGGVGASGMGRYHGKFSFDTFS 423
                +LPFGG+ +SG+GR   K S+D F+
Sbjct: 451 RE--LNLPFGGMKSSGIGREGAKDSYDFFT 478


>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
           sapiens]
          Length = 535

 Score =  130 bits (327), Expect = 3e-30
 Identities = 100/340 (29%), Positives = 162/340 (47%), Gaps = 18/340 (5%)

Query: 98  AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
           A + K+P G+  +I PWN+P  +    +  ALAAG  VV+KP+E +      LAE+  Q 
Sbjct: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247

Query: 158 -VDQSCFAVV---LGGPQETGQLL--EHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLEL 211
            +    + V+       +E G+ +  +     I FTGS   GKI++  AA  +  V++EL
Sbjct: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307

Query: 212 GGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITR 270
           GG  P  V D+ +  Q VA  +A  ++ N GQTCV  +  L    + +  + A    + +
Sbjct: 308 GGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKK 366

Query: 271 --FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSDE-SDRYIAPTVLV 322
               G+  +     G +IN+K  +++      A+     V  GG+  +    +  PT+L 
Sbjct: 367 NLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLC 426

Query: 323 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 382
           +V +      EE FGP+ P++   + +EAI   N  +  LA Y +S     + RV  Q  
Sbjct: 427 NVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLE 486

Query: 383 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
            G    N+G   ++    PFGGV  SG+GR   K+  D +
Sbjct: 487 VGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 524


>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
          Length = 422

 Score =  127 bits (320), Expect = 2e-29
 Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)

Query: 99  FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
           F R EP G+   I PWN+PL +    +  AL  GN VV+KP+E +      +  ++ +  
Sbjct: 75  FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134

Query: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
                  ++ G GP     +  H   D I FTGS  VGK++  AA + +L  VTLELGGK
Sbjct: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194

Query: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 273
           +P  +  + D      +     +FN GQ C A   +     + E  +  +++    R  G
Sbjct: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254

Query: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
                +   G  I++KQ+ ++  L+  G     ++  GG+       +I PTV  +V + 
Sbjct: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314

Query: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
             + +EEIFGP+  I+  +++DE IE  N  +  L    F+N       V +   +G   
Sbjct: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374

Query: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
            N    +   A  PFGG   SG GR  G+F    +S  +   ++ P
Sbjct: 375 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 418


>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
          Length = 518

 Score =  127 bits (320), Expect = 2e-29
 Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)

Query: 99  FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
           F R EP G+   I PWN+PL +    +  AL  GN VV+KP+E +      +  ++ +  
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230

Query: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
                  ++ G GP     +  H   D I FTGS  VGK++  AA + +L  VTLELGGK
Sbjct: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290

Query: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 273
           +P  +  + D      +     +FN GQ C A   +     + E  +  +++    R  G
Sbjct: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350

Query: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
                +   G  I++KQ+ ++  L+  G     ++  GG+       +I PTV  +V + 
Sbjct: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410

Query: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
             + +EEIFGP+  I+  +++DE IE  N  +  L    F+N       V +   +G   
Sbjct: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470

Query: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
            N    +   A  PFGG   SG GR  G+F    +S  +   ++ P
Sbjct: 471 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 514


>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
           sapiens]
          Length = 548

 Score =  127 bits (320), Expect = 2e-29
 Identities = 103/353 (29%), Positives = 163/353 (46%), Gaps = 31/353 (8%)

Query: 98  AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
           A + K+P G+  +I PWN+P  +    +  ALAAG  VV+KP+E +      LAEV   +
Sbjct: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGF 247

Query: 158 ---VDQSCFAVVLGGP--------------QETGQLL--EHRFDYIFFTGSPRVGKIVMT 198
              +D    A   G P              +E G+ +  +     I FTGS   GKI++ 
Sbjct: 248 LLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 307

Query: 199 AAAKHLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQ 257
            AA  +  V++ELGG  P  V D+ +  Q VA  +A  ++ N GQTCV  +  L    + 
Sbjct: 308 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIH 366

Query: 258 ERLLPALQSTITR--FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSD 310
           +  + A    + +    G+  +     G +IN+K  +++      A+     V  GG+  
Sbjct: 367 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 426

Query: 311 E-SDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSN 369
           +    +  PT+L +V +      EE FGP+ P++   + +EAI   N  +  LA Y +S 
Sbjct: 427 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 486

Query: 370 SSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
               + RV  Q   G    N+G   ++    PFGGV  SG+GR   K+  D +
Sbjct: 487 DPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 537


>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
           sapiens]
          Length = 517

 Score =  127 bits (319), Expect = 2e-29
 Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 13/347 (3%)

Query: 98  AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
           ++ R EP G+   I PWN+PL +    L  ALA GN VV+K +E +      +A ++ + 
Sbjct: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228

Query: 158 -VDQSCFAVVLG-GPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAA-AKHLTPVTLELGG 213
                   +V G GP     +  H   D + FTGS  +G+++  AA + +L  VTLELGG
Sbjct: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288

Query: 214 KNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFY 272
           K+P  +  + D      +  +  +FN GQ C A        ++ +  +  ++    +R  
Sbjct: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348

Query: 273 GDDPQSSPNLGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQE 326
           G+   S    G  +++ QF+++   +  G+      +  GG + +   +I PTV  DVQ+
Sbjct: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408

Query: 327 MEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGF 386
              + +EEIFGP++ I+  ++++E +   N     LA   F+        +     +G  
Sbjct: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468

Query: 387 CGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
             N     +  A  PFGG   SG GR  G++    ++  +   ++ P
Sbjct: 469 WVN--CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVP 513


>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
          Length = 517

 Score =  124 bits (310), Expect = 2e-28
 Identities = 116/440 (26%), Positives = 180/440 (40%), Gaps = 20/440 (4%)

Query: 8   LRRLREAFHAG---RTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEV 64
           ++  REAF  G   R   A  R   L  L   ++ ++  L      D  K   ES     
Sbjct: 80  VKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQES----Y 135

Query: 65  AISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVP 124
           A+   EV    R    W                 F R EP G+   I PWN+PL +    
Sbjct: 136 ALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWK 195

Query: 125 LVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQLLEH-RF 181
           L  ALA GN VV+K +E +      LA ++ +         ++ G GP     + +H   
Sbjct: 196 LAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDV 255

Query: 182 DYIFFTGSPRVGKIVMTAAA-KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
           D + FTGS  VG ++  AA   +L  VTLELGGK+P  V  + D +    +     +FN 
Sbjct: 256 DKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNM 315

Query: 241 GQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLG 299
           GQ C A         +    L   ++    R  G+  +     G  ++++QF+R+   + 
Sbjct: 316 GQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQ 375

Query: 300 CG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIE 353
            G     ++  GG+   E   +I PTV   VQ+   + +EEIFGP+ P+   + ++E +E
Sbjct: 376 LGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVE 435

Query: 354 FINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRY 413
             N     LA   F+              +G    N    ++     PFGG   SG GR 
Sbjct: 436 RANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNT--YNIVTCHTPFGGFKESGNGRE 493

Query: 414 HGKFSFDTFSHHRACLLRSP 433
            G+     ++  +   ++ P
Sbjct: 494 LGEDGLKAYTEVKTVTIKVP 513


>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
          Length = 501

 Score =  122 bits (305), Expect = 9e-28
 Identities = 112/436 (25%), Positives = 192/436 (44%), Gaps = 32/436 (7%)

Query: 8   LRRLREAFHAG---RTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEV 64
           ++  R+AF  G   RT  A  R   L  L   ++ ++ LL    + +  K    + ++++
Sbjct: 64  VKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDL 123

Query: 65  AISQGEVTLALRNLRAW---MKDERVPKNLATQLDSAFI---RKEPFGLVLIIAPWNYPL 118
           A         LR    W   ++   +P      +D  F    R EP G+   I PWN+PL
Sbjct: 124 A----GCIKTLRYCAGWADKIQGRTIP------IDGNFFTYTRHEPIGVCGQIIPWNFPL 173

Query: 119 NLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQL 176
            + +  +  AL+ GN VV+KP+E +      +A ++ +         +V G GP     +
Sbjct: 174 VMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAI 233

Query: 177 LEHR-FDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPCYVDDNCDPQTVANRVAW 234
             H   D + FTGS  VGK++  AA K +L  VTLELGGK+PC V  + D          
Sbjct: 234 SSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHH 293

Query: 235 FRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQS-SPNLGRIINQKQFQR 293
             +++ GQ C+A   +     + +  +        ++   +P +     G  I+++Q+ +
Sbjct: 294 GVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDK 353

Query: 294 LRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS 347
           +  L+  G+         GG       ++ PTV  +V +   + +EEIFGP+  I+  +S
Sbjct: 354 ILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKS 413

Query: 348 LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGA 407
           LD+ I+  N     L+   F+        + +   +G    N     +  A  PFGG   
Sbjct: 414 LDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKM 471

Query: 408 SGMGRYHGKFSFDTFS 423
           SG GR  G++ F  ++
Sbjct: 472 SGNGRELGEYGFHEYT 487


>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
           sapiens]
          Length = 923

 Score =  120 bits (302), Expect = 2e-27
 Identities = 114/430 (26%), Positives = 186/430 (43%), Gaps = 25/430 (5%)

Query: 12  REAFHAGR--TRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQG 69
           ++AF  G      A  R   +  L   L+EN++ L  A  + L   A  +   +  I   
Sbjct: 490 KDAFENGEWGRMNARERGRLMYRLADLLEENQEEL--ATIEALDSGAVYTLALKTHIGMS 547

Query: 70  EVTLALRNLRAW---MKDERVPKNLAT-QLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPL 125
             T   R    W   ++   +P N A    +  F +KEP G+  II PWNYPL +     
Sbjct: 548 VQTF--RYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKS 605

Query: 126 VGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVDQSCFAVVLGGPQETGQLLEHRFDY- 183
              LAAGN +VLKP++++       AE+ +     +    ++ G     GQ L    D  
Sbjct: 606 AACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIR 665

Query: 184 -IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAG 241
            + FTGS  +GK +M + A  +L  V+LELGGK+P  + ++C+            +FN G
Sbjct: 666 KLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKG 725

Query: 242 QTCVAPDYVLCSPEMQERLLPALQSTITRF-YGDDPQSSPNLGRIINQKQFQRLRALL-- 298
           + C+A   +     + +  +  +   I +   GD    S + G   ++   ++L      
Sbjct: 726 ENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCET 785

Query: 299 ----GCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS--LDEAI 352
               G   V  G Q      ++ PTV  DV++   + +EE FGPI+ I   Q+  +D  +
Sbjct: 786 GVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVL 845

Query: 353 EFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGR 412
           +  N  E  LA   F+        V  +  +G    N    + T  + PFGGV  SG G+
Sbjct: 846 QRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINT--YNKTDVAAPFGGVKQSGFGK 903

Query: 413 YHGKFSFDTF 422
             G+ + + +
Sbjct: 904 DLGEEALNEY 913


>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
          Length = 433

 Score =  117 bits (294), Expect = 2e-26
 Identities = 110/434 (25%), Positives = 185/434 (42%), Gaps = 66/434 (15%)

Query: 2   DPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEV 61
           D +   ++  REAF +  +R  + R+  L  +   L+++ +    A ++D  K+   +  
Sbjct: 45  DEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALART 104

Query: 62  SEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSA----FIRKEPFGLVLIIAPWNYP 117
            ++  S       ++N R +        +  TQ+D      +  + P G+  +I+PWN P
Sbjct: 105 MDIPRS-------VQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLP 157

Query: 118 LNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQ 175
           L L    +  A+AAGN V+ KPSE++     +L ++L +  V      +V G GP+    
Sbjct: 158 LYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEA 217

Query: 176 LLEH-RFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVD-----DNCDPQTVA 229
           L+ H     I FTGS    + +   +A H   ++LELGGKNP  +      D C P TV 
Sbjct: 218 LVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVR 277

Query: 230 NRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQK 289
           +  A        +       + C   + +  LPA                          
Sbjct: 278 SSFANQVRSYVKRALAEGAQIWCGEGVDKLSLPA-------------------------- 311

Query: 290 QFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLD 349
                               +++  ++ PTV+ D+++    M EEIFGP+  +V   S +
Sbjct: 312 -------------------RNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEE 352

Query: 350 EAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
           E IE  N  +  LA   +S++   V RV  +  SG    N   +     +LPFGG+ +SG
Sbjct: 353 EVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRE--LNLPFGGMKSSG 410

Query: 410 MGRYHGKFSFDTFS 423
           +GR   K S+D F+
Sbjct: 411 IGREGAKDSYDFFT 424


>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
           sapiens]
          Length = 902

 Score =  112 bits (280), Expect = 7e-25
 Identities = 91/335 (27%), Positives = 145/335 (43%), Gaps = 15/335 (4%)

Query: 101 RKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVD 159
           RKEP G+  II PWNYPL +        LAAGN VV+KP++++       AE+ L   + 
Sbjct: 560 RKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP 619

Query: 160 QSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNP 216
           +    V+ G     GQ L    D   I FTGS  VGK +M + A  ++  V+LELGGK+P
Sbjct: 620 KGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSP 679

Query: 217 CYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDP 276
             +  +CD            +FN G+ C+A   +     + +  +  +   + +    +P
Sbjct: 680 LIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNP 739

Query: 277 QS-------SPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEP 329
                      +   ++   ++ +     G   V  G Q      +  PTV  DV++   
Sbjct: 740 LDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMF 799

Query: 330 VMQEEIFGPILPIVNVQ--SLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
           + +EE FGP++ I       LD  +   N  E  LA   F+        V  +  +G   
Sbjct: 800 IAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVF 859

Query: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
            N    + T  + PFGG   SG G+  G+ + + +
Sbjct: 860 VNT--YNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892


>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
          Length = 480

 Score =  108 bits (270), Expect = 1e-23
 Identities = 89/343 (25%), Positives = 145/343 (42%), Gaps = 45/343 (13%)

Query: 99  FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYV 158
           F R EP G+   I PWN+PL +    +  AL  GN VV+KP+E +      +  ++ +  
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228

Query: 159 DQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPC 217
                                            VGK++  AA + +L  VTLELGGK+P 
Sbjct: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255

Query: 218 YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDP 276
            +  + D      +     +FN GQ C A   +     + E  +  +++    R  G   
Sbjct: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315

Query: 277 QSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPV 330
             +   G  I++KQ+ ++  L+  G     ++  GG+       +I PTV  +V +   +
Sbjct: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375

Query: 331 MQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND 390
            +EEIFGP+  I+  +++DE IE  N  +  L    F+N       V +   +G    N 
Sbjct: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434

Query: 391 GFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
              +   A  PFGG   SG GR  G+F    +S  +   ++ P
Sbjct: 435 -CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 476


>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
          Length = 535

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 64/265 (24%), Positives = 121/265 (45%), Gaps = 12/265 (4%)

Query: 104 PFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSC 162
           P G+   IAP+N+P  + L     A+  GN  ++KPSE       +LA++L         
Sbjct: 175 PLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGT 234

Query: 163 FAVVLGGPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDD 221
             ++ G  +    + +H     I F GS + G+ +    ++H   V   +G KN   V  
Sbjct: 235 LNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMP 294

Query: 222 NCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPN 281
           + + +   N++    +  AGQ C+A    +   E ++ L   ++           Q   +
Sbjct: 295 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGAD 354

Query: 282 LGRIINQKQFQRLRALLGCGR-----VAIGGQSD-----ESDRYIAPTVLVDVQEMEPVM 331
           LG +I  +  +R+  L+  G      + + G+       E+  ++ PT++ +V+      
Sbjct: 355 LGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCY 414

Query: 332 QEEIFGPILPIVNVQSLDEAIEFIN 356
           +EEIFGP+L ++  ++LDEAI+ +N
Sbjct: 415 KEEIFGPVLVVLETETLDEAIQIVN 439


>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
           sapiens]
          Length = 539

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 108/450 (24%), Positives = 180/450 (40%), Gaps = 40/450 (8%)

Query: 6   DTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFES--EVSE 63
           +T+++ REA+      PA  R   ++ +G  L+E  Q+L   ++ ++ K   E   EV E
Sbjct: 90  ETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQE 149

Query: 64  -VAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTL 122
            V I    V L+       +  ER    L  Q +       P GLV II  +N+P+ +  
Sbjct: 150 YVDICDYAVGLSRMIGGPILPSERSGHALIEQWN-------PVGLVGIITAFNFPVAVYG 202

Query: 123 VPLVGALAAGNCVVLK----PSEISKNVEKILAEVLP--QYVDQSCFAVVLGGPQETGQL 176
                A+  GN  + K     S IS  V KI+A+VL   +     C     G    T   
Sbjct: 203 WNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMA 262

Query: 177 LEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFR 236
            + R + + FTGS +VGK V     +      LELGG N     ++ D   V     +  
Sbjct: 263 KDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAA 322

Query: 237 YFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRA 296
              AGQ C     +     + + ++  L+    +    +P     L   ++ K  Q +  
Sbjct: 323 VGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTK--QAVSM 380

Query: 297 LLGC--------GRVAIGGQ-SDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS 347
            LG         G V  GG+  D    Y+ PT++  +     +   E F PIL +   ++
Sbjct: 381 FLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKN 440

Query: 348 LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND-GFMHMTLASL------ 400
            +E   + N  ++ L+   F+     + R L      G  G+D G +++ + +       
Sbjct: 441 EEEVFAWNNEVKQGLSSSIFTKDLGRIFRWL------GPKGSDCGIVNVNIPTSGAEIGG 494

Query: 401 PFGGVGASGMGRYHGKFSFDTFSHHRACLL 430
            FGG   +G GR  G  ++  +     C +
Sbjct: 495 AFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524


>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)

Query: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157
           G V  I+P+N+     NL   P +     GN V+ KPS+     S  V +IL E  LP  
Sbjct: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257

Query: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209
           + Q    V   GP   +T    EH    I FTGS    K +    A++L        +  
Sbjct: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313

Query: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269
           E GGKN  +V  + D ++V +      +   GQ C A   +     +  ++   L    +
Sbjct: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373

Query: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320
           R    DP          +I+ K F R++  L   R      +  GG+ D+S  Y + P +
Sbjct: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433

Query: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377
           +      EP+M+EEIFGP+L +         E ++ ++      L    FS    VV+  
Sbjct: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493

Query: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
             + + ++G F  ND      +   PFGG  ASG
Sbjct: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527


>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
          Length = 503

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)

Query: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157
           G V  I+P+N+     NL   P +     GN V+ KPS+     S  V +IL E  LP  
Sbjct: 142 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 197

Query: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209
           + Q    V   GP   +T    EH    I FTGS    K +    A++L        +  
Sbjct: 198 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 253

Query: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269
           E GGKN  +V  + D ++V +      +   GQ C A   +     +  ++   L    +
Sbjct: 254 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 313

Query: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320
           R    DP          +I+ K F R++  L   R      +  GG+ D+S  Y + P +
Sbjct: 314 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 373

Query: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377
           +      EP+M+EEIFGP+L +         E ++ ++      L    FS    VV+  
Sbjct: 374 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 433

Query: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
             + + ++G F  ND      +   PFGG  ASG
Sbjct: 434 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 467


>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)

Query: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157
           G V  I+P+N+     NL   P +     GN V+ KPS+     S  V +IL E  LP  
Sbjct: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257

Query: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209
           + Q    V   GP   +T    EH    I FTGS    K +    A++L        +  
Sbjct: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313

Query: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269
           E GGKN  +V  + D ++V +      +   GQ C A   +     +  ++   L    +
Sbjct: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373

Query: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320
           R    DP          +I+ K F R++  L   R      +  GG+ D+S  Y + P +
Sbjct: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433

Query: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377
           +      EP+M+EEIFGP+L +         E ++ ++      L    FS    VV+  
Sbjct: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493

Query: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
             + + ++G F  ND      +   PFGG  ASG
Sbjct: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527


>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
           [Homo sapiens]
          Length = 751

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 55/195 (28%), Positives = 83/195 (42%), Gaps = 20/195 (10%)

Query: 26  RAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAWMKDE 85
           RAA L  L   L+  K  L          S  E + +E+  ++ EV L+ R LRAW    
Sbjct: 537 RAALLWALAAALERRKSTL---------ASRLERQGAELKAAEAEVELSARRLRAW--GA 585

Query: 86  RVPKNLATQLDSAFIR------KEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKP 139
           RV     T L  A +R      +EP G++ ++ P  +PL   +  L  ALA GN VV+ P
Sbjct: 586 RVQAQGHT-LQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVP 644

Query: 140 SEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM 197
           S     +   + + +          VV G      + L    D   +++ GS +  + V 
Sbjct: 645 SAACPLLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVE 704

Query: 198 TAAAKHLTPVTLELG 212
            A+A +L PV    G
Sbjct: 705 WASAGNLKPVWASRG 719


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,783,283
Number of Sequences: 37866
Number of extensions: 788514
Number of successful extensions: 1720
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1625
Number of HSP's gapped (non-prelim): 40
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press