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Search of human proteins with 41406086
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41406086 semaphorin 3D [Homo sapiens]
(777 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41406086 semaphorin 3D [Homo sapiens] 1603 0.0
gi|5174673 semaphorin 3A precursor [Homo sapiens] 862 0.0
gi|6912650 semaphorin 3E [Homo sapiens] 718 0.0
gi|188497703 semaphorin 3F [Homo sapiens] 697 0.0
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 684 0.0
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 679 0.0
gi|5454048 semaphorin 3C [Homo sapiens] 677 0.0
gi|9910362 semaphorin sem2 [Homo sapiens] 653 0.0
gi|157388902 semaphorin 4C [Homo sapiens] 338 9e-93
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 332 8e-91
gi|28872814 semaphorin 4G [Homo sapiens] 327 2e-89
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 322 6e-88
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 315 1e-85
gi|39777610 semaphorin 4B precursor [Homo sapiens] 313 3e-85
gi|39777608 semaphorin 4B precursor [Homo sapiens] 313 3e-85
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 313 4e-85
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 313 4e-85
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 313 5e-85
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 305 8e-83
gi|19923279 semaphorin W [Homo sapiens] 296 4e-80
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 289 8e-78
gi|21361914 semaphorin B [Homo sapiens] 288 1e-77
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 270 3e-72
gi|16306552 semaphorin Y [Homo sapiens] 266 4e-71
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 249 9e-66
gi|147904700 semaphorin 5A [Homo sapiens] 248 2e-65
gi|19718780 semaphorin 6B precursor [Homo sapiens] 246 8e-65
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 194 3e-49
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 190 5e-48
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 180 4e-45
>gi|41406086 semaphorin 3D [Homo sapiens]
Length = 777
Score = 1603 bits (4152), Expect = 0.0
Identities = 777/777 (100%), Positives = 777/777 (100%)
Query: 1 MNANKDERLKARSQDFHLFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIP 60
MNANKDERLKARSQDFHLFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIP
Sbjct: 1 MNANKDERLKARSQDFHLFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIP 60
Query: 61 FLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLA 120
FLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLA
Sbjct: 61 FLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLA 120
Query: 121 GKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGR 180
GKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGR
Sbjct: 121 GKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGR 180
Query: 181 LKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNG 240
LKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNG
Sbjct: 181 LKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNG 240
Query: 241 AKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKW 300
AKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKW
Sbjct: 241 AKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKW 300
Query: 301 TTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVY 360
TTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVY
Sbjct: 301 TTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVY 360
Query: 361 SMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISF 420
SMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISF
Sbjct: 361 SMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISF 420
Query: 421 IKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVV 480
IKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVV
Sbjct: 421 IKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVV 480
Query: 481 SISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKA 540
SISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKA
Sbjct: 481 SISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKA 540
Query: 541 CADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKV 600
CADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKV
Sbjct: 541 CADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKV 600
Query: 601 IFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDS 660
IFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDS
Sbjct: 601 IFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDS 660
Query: 661 GMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEHEEGKVKDLLAESRLRYKDYIQIL 720
GMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEHEEGKVKDLLAESRLRYKDYIQIL
Sbjct: 661 GMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEHEEGKVKDLLAESRLRYKDYIQIL 720
Query: 721 SSPNFSLDQYCEQMWHREKRRQRNKGGPKWKHMQEMKKKRNRRHHRDLDELPRAVAT 777
SSPNFSLDQYCEQMWHREKRRQRNKGGPKWKHMQEMKKKRNRRHHRDLDELPRAVAT
Sbjct: 721 SSPNFSLDQYCEQMWHREKRRQRNKGGPKWKHMQEMKKKRNRRHHRDLDELPRAVAT 777
>gi|5174673 semaphorin 3A precursor [Homo sapiens]
Length = 771
Score = 862 bits (2227), Expect = 0.0
Identities = 414/752 (55%), Positives = 556/752 (73%), Gaps = 21/752 (2%)
Query: 39 KQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDL 98
K N+PRLKL+YK++L SN+ I F G + + T LLDEER RL +GAKDHIF LV++
Sbjct: 26 KNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNI 85
Query: 99 NKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYI 158
K+F+KI WP + R + CK AGKD ECANFI+VL+ YN+TH+Y CGTGAFHPIC YI
Sbjct: 86 -KDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYI 144
Query: 159 DLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRS 218
++G + ED IFKL+ + E+GR K P+DP+ AS++ D LYSGTA+DF+G+D A R+
Sbjct: 145 EIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRT 204
Query: 219 LGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTI 278
LG HH IRT+ + WLN KFI I ++ NP+DDK+YFFFRE++ +G S K
Sbjct: 205 LG---HHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKAT 261
Query: 279 LSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERN 338
+R+G++CKND GG RSL+NKWTTFLKARLICS+PG +G DT+FDELQD++L+ +D +N
Sbjct: 262 HARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKN 321
Query: 339 PVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTC 398
PVVYGVFTT+S+IFKGSAVC+YSM+D+R VF GPYAH++ +++WV Y GR+PYPRPGTC
Sbjct: 322 PVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTC 381
Query: 399 PSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVI 458
PSKT+ ST+D PDDVI+F + H MY V+P+ P + +V+Y+ TQIVVD V
Sbjct: 382 PSKTFGG-FDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVD 440
Query: 459 AEDGQYDVMFLGTDIGTVLKVVSISKEKW-NMEEVVLEELQIFKHSSIILNMELSLKQQQ 517
AEDGQYDVMF+GTD+GTVLKVVSI KE W ++EEV+LEE+ +F+ + I MELS KQQQ
Sbjct: 441 AEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQ 500
Query: 518 LYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKY 577
LYIGS G+ QL LHRCD YGKACA+CCLARDPYCAWDG+ACSRY PT+KRR RRQD++
Sbjct: 501 LYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRN 560
Query: 578 GDPITQCWDIEDSISH-ETADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREE 636
GDP+T C D+ H + +E++I+G+E +STFLEC PKSQ+A + W QR +E +EE
Sbjct: 561 GDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEE 620
Query: 637 LKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAE 696
++ D+ II+T+ GLL+RSLQ+KDSG Y C A EH FI T++K+TL VI+ E +E +
Sbjct: 621 IRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKD 680
Query: 697 H--EEGKVKD----LLAESRLRYKDYIQILSSPNF-SLDQYCEQMWHREKRRQRNKGG-- 747
+ K K+ + ++ Y+D++Q+++ PN ++D++CEQ+W R+++++R + G
Sbjct: 681 DDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHT 740
Query: 748 ----PKWKHMQEMKKKRNRRHHRDLDELPRAV 775
KWKH+QE KK RNRR H + + PR+V
Sbjct: 741 PGNSNKWKHLQENKKGRNRRTH-EFERAPRSV 771
>gi|6912650 semaphorin 3E [Homo sapiens]
Length = 775
Score = 718 bits (1853), Expect = 0.0
Identities = 350/750 (46%), Positives = 505/750 (67%), Gaps = 29/750 (3%)
Query: 43 PRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF 102
PRL+L++K+LL N F LD T+LLDE + RL +G +D ++ LSL ++ +
Sbjct: 31 PRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY 90
Query: 103 KKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGV 162
K+I+WP+ ++E C + GKDA ECAN++RVL YN+TH+ CGTGAF P+C +I +G
Sbjct: 91 KEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGY 149
Query: 163 YKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPT 222
+ ED +F L++ E GR +CPFDP F S + L++G SD+ +D A RS+G
Sbjct: 150 HLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRL 209
Query: 223 HDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRV 282
+IRT+ + L KF+G++ IPD + DD+K+YFFF E + E + I +RV
Sbjct: 210 A---HIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRV 266
Query: 283 GRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVY 342
GR+C NDVGGQR L+NKW+TFLKARL+CS+PG +G DTYFDEL+D++LLPTRD +NPV++
Sbjct: 267 GRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIF 326
Query: 343 GVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKT 402
G+F TTS+IF+G A+CVY M+ IRA FNGPYAHKE ++ W Y+G++PYPRPG+C SK
Sbjct: 327 GLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKV 386
Query: 403 YDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDG 462
+T+D+PDD I F + H +MY+++ P P + + Y L QI VD V AEDG
Sbjct: 387 NGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDG 446
Query: 463 QYDVMFLGTDIGTVLKVVSI-SKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIG 521
QYDV+F+GTD G VLKV++I ++E +MEEV+LEELQIFK I++ME+S K+QQLYIG
Sbjct: 447 QYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIG 506
Query: 522 SRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPT---SKRRARRQDVKYG 578
S + Q+ H CD YG ACADCCLARDPYCAWDG +CSRY PT +KRR RRQDV++G
Sbjct: 507 SASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHG 566
Query: 579 DPITQCWD---IEDSISHETADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHRE 635
+ QC+ + D++ + +E + +GIE NST LEC P+S QA + W++Q+ + +E
Sbjct: 567 NAAQQCFGQQFVGDAL--DKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGRETRKE 624
Query: 636 ELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRA 695
E+K D+R++K + GLL L K D+G Y+C+ EH+F+HT+ K+TL V+E E++E+
Sbjct: 625 EVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNK 684
Query: 696 EHEEGK--------VKDLLAESRLRYKDYIQILSSPNFS-LDQYCEQMWHREKRRQRNKG 746
+ EE + + ++ YK+++Q++ NF +++YCE++W +++R++ K
Sbjct: 685 DDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYSNFQRVEEYCEKVWCTDRKRKKLKM 744
Query: 747 GP-KWKHM--QEMKKKRNRRHHRDLDELPR 773
P KWK+ QE K + H+R LPR
Sbjct: 745 SPSKWKYANPQEKKLRSKPEHYR----LPR 770
>gi|188497703 semaphorin 3F [Homo sapiens]
Length = 785
Score = 697 bits (1798), Expect = 0.0
Identities = 343/762 (45%), Positives = 490/762 (64%), Gaps = 49/762 (6%)
Query: 43 PRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF 102
PR++L++K+L + + F D++ LL DE+ R+ +G+KD++ L L D+N+
Sbjct: 30 PRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREP 89
Query: 103 KKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLG- 161
I+W A+ +R+E C L+GKD N EC NF+R++QP+N+TH+YVCGTGA++P+C Y++ G
Sbjct: 90 LIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGR 149
Query: 162 ------------------------------VYKEDIIFKLDTHNLESGRLKCPFDPQQPF 191
++D IF L+ LESG+ KCP+DP+
Sbjct: 150 RAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDT 209
Query: 192 ASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPD 251
AS + +E LY+G DF+G D A R+LG +RTD WLN FI IPD
Sbjct: 210 ASALINEELYAGVYIDFMGTDAAIFRTLG---KQTAMRTDQYNSRWLNDPSFIHAELIPD 266
Query: 252 TYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICS 311
+ +DDK+YFFFRE S E S + +R+GR+C ND GG L+NKW+TFLKARL+CS
Sbjct: 267 SAERNDDKLYFFFRERSAEAPQS-PAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCS 325
Query: 312 IPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNG 371
+PG DG +T+FDELQD+++ T+D RNPV+Y VFT++ S+F+GSAVCVYSMADIR VFNG
Sbjct: 326 VPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNG 385
Query: 372 PYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSV 431
P+AHKE +++W+ + G++PYPRPGTCP T+ P +KST+D+PD+VI+F++ H +MY++V
Sbjct: 386 PFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAV 445
Query: 432 YPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVSISKEKWNMEE 491
YP+ P R YRLT I VD V A DG+Y+V+FLGTD GTV KV+ + K+ +EE
Sbjct: 446 YPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEE 505
Query: 492 VVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPY 551
++LEE+++FK + + M +S K+QQLY+ S G+ LSLHRC YG ACADCCLARDPY
Sbjct: 506 LMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPY 565
Query: 552 CAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFL 611
CAWDG ACSRY +SKRR+RRQDV++G+PI QC +S +++ A E V +G+ ++ FL
Sbjct: 566 CAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGF-NSNANKNAVESVQYGVAGSAAFL 624
Query: 612 ECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHT 671
EC P+S QAT+KW QR + R E++ ++R ++TE GLL+R+LQ D G+Y C A E+
Sbjct: 625 ECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENN 684
Query: 672 FIHTIVKLTLNVIENEQMEN------TQRAEHEEGKVKDLLAESRLRYKDYIQILSSPNF 725
F H + ++ L+V+ + + + A G Y++ Q+L+ P
Sbjct: 685 FKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPG-----AGPPTPPYQELAQLLAQPEV 739
Query: 726 SL-DQYCEQMW-HREKRRQRNKGGPKWKHMQEMKKKRNRRHH 765
L QYC+ W H + G P+ Q+ KK RNRRHH
Sbjct: 740 GLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRHH 781
>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
Length = 749
Score = 684 bits (1765), Expect = 0.0
Identities = 345/753 (45%), Positives = 490/753 (65%), Gaps = 25/753 (3%)
Query: 21 ALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERG 80
A ++ + +L+ G+ + PRL+L++++L + F +Q LL+DEERG
Sbjct: 7 AAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTF-SLERTCCYQALLVDEERG 65
Query: 81 RLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNK 140
RL +GA++H+ L+L +++K KK+ WPA E E C AGKD TEC NF+++L YN+
Sbjct: 66 RLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNR 125
Query: 141 THIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYL 200
TH+ CGTGAFHP C ++++G E+ + +LD +E G+ K P+DP+ ASV+ E L
Sbjct: 126 THLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185
Query: 201 YSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKI 260
YSG A+D +G+D RSLG +RT+ + WLN KF+ F+IP++ NPDDDKI
Sbjct: 186 YSGVAADLMGRDFTIFRSLG---QRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKI 242
Query: 261 YFFFRESSQEGSTS-DKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGAD 319
YFFFRE++ E + + + +SRVG++C+NDVGGQRSL+NKWTTFLKARL+CS+PG +G D
Sbjct: 243 YFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-D 301
Query: 320 TYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESA 379
T+FD+LQD++LL +RD R P++Y VF+T+SSIF+GSAVCVYSM D+R F GP+AHKE
Sbjct: 302 THFDQLQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGP 361
Query: 380 DHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPT 439
H+WV Y GR+PYPRPG CPSKT+ ST+DFPDDVI F + H +MY SV P G P
Sbjct: 362 MHQWVSYQGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 420
Query: 440 FKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVSISK-EKWNMEEVVLEELQ 498
F ++ +Y TQI D V A DG YDV+F+GTD+GTVLKV+S+ K + + E ++LEEL
Sbjct: 421 FLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELH 480
Query: 499 IFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNA 558
+F+ S+ + +M++S K+ QLY+ SR + Q++LHRC +G+ C +CCLARDPYCAWDG A
Sbjct: 481 VFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVA 540
Query: 559 CSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFLECIPKSQ 618
C+R+ P++KRR RRQDV+ GDP T C S E +FG+E +S FLEC P+S
Sbjct: 541 CTRFQPSAKRRFRRQDVRNGDPSTLC---SGDSSRPALLEHKVFGVEGSSAFLECEPRSL 597
Query: 619 QATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVK 678
QA ++W QR+G ++ +ER +T GLL+R L+++DSG+Y C A E F + +
Sbjct: 598 QARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRR 657
Query: 679 LTLNVIENEQMENTQRAEHEEGKVKDLLAESRLRYKDYIQIL--------SSPNFSLDQY 730
L+L+V+ Q E RAE +L Y+D++Q++ +S Q
Sbjct: 658 LSLHVLSATQAERLARAEEAAPAAP---PGPKLWYRDFLQLVEPGGGGSANSLRMCRPQP 714
Query: 731 CEQMWHREKRRQRNKGGPKWKHMQEMKKKRNRR 763
Q E RR KG + H E + +R R
Sbjct: 715 ALQSLPLESRR---KGRNRRTHAPEPRAERGPR 744
>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
Length = 748
Score = 679 bits (1752), Expect = 0.0
Identities = 345/753 (45%), Positives = 489/753 (64%), Gaps = 26/753 (3%)
Query: 21 ALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERG 80
A ++ + +L+ G+ + PRL+L++++L + F +Q LL+DEERG
Sbjct: 7 AAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTF-SLERTCCYQALLVDEERG 65
Query: 81 RLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNK 140
RL +GA++H+ L+L +++K KK+ WPA E E C AGKD TEC NF+++L YN+
Sbjct: 66 RLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNR 125
Query: 141 THIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYL 200
TH+ CGTGAFHP C ++++G E+ + +LD +E G+ K P+DP+ ASV+ E L
Sbjct: 126 THLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185
Query: 201 YSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKI 260
YSG A+D +G+D RSLG +RT+ + WLN KF+ F+IP++ NPDDDKI
Sbjct: 186 YSGVAADLMGRDFTIFRSLG---QRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKI 242
Query: 261 YFFFRESSQEGSTS-DKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGAD 319
YFFFRE++ E + + + +SRVG++C+NDVGGQRSL+NKWTTFLKARL+CS+PG +G D
Sbjct: 243 YFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-D 301
Query: 320 TYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESA 379
T+FD+LQD++LL +RD R P++Y VF +TSSIF+GSAVCVYSM D+R F GP+AHKE
Sbjct: 302 THFDQLQDVFLLSSRDHRTPLLYAVF-STSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGP 360
Query: 380 DHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPT 439
H+WV Y GR+PYPRPG CPSKT+ ST+DFPDDVI F + H +MY SV P G P
Sbjct: 361 MHQWVSYQGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 419
Query: 440 FKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVSISK-EKWNMEEVVLEELQ 498
F ++ +Y TQI D V A DG YDV+F+GTD+GTVLKV+S+ K + + E ++LEEL
Sbjct: 420 FLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELH 479
Query: 499 IFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNA 558
+F+ S+ + +M++S K+ QLY+ SR + Q++LHRC +G+ C +CCLARDPYCAWDG A
Sbjct: 480 VFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVA 539
Query: 559 CSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFLECIPKSQ 618
C+R+ P++KRR RRQDV+ GDP T C S E +FG+E +S FLEC P+S
Sbjct: 540 CTRFQPSAKRRFRRQDVRNGDPSTLC---SGDSSRPALLEHKVFGVEGSSAFLECEPRSL 596
Query: 619 QATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVK 678
QA ++W QR+G ++ +ER +T GLL+R L+++DSG+Y C A E F + +
Sbjct: 597 QARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRR 656
Query: 679 LTLNVIENEQMENTQRAEHEEGKVKDLLAESRLRYKDYIQIL--------SSPNFSLDQY 730
L+L+V+ Q E RAE +L Y+D++Q++ +S Q
Sbjct: 657 LSLHVLSATQAERLARAEEAAPAAP---PGPKLWYRDFLQLVEPGGGGSANSLRMCRPQP 713
Query: 731 CEQMWHREKRRQRNKGGPKWKHMQEMKKKRNRR 763
Q E RR KG + H E + +R R
Sbjct: 714 ALQSLPLESRR---KGRNRRTHAPEPRAERGPR 743
>gi|5454048 semaphorin 3C [Homo sapiens]
Length = 751
Score = 677 bits (1746), Expect = 0.0
Identities = 337/726 (46%), Positives = 483/726 (66%), Gaps = 12/726 (1%)
Query: 44 RLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFK 103
R+ LT+ +L + + F S LD++ LL+DE++ R+ +G+KDHI L++ ++++
Sbjct: 28 RVYLTFDELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEAL 87
Query: 104 KIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVY 163
++WPA+ +VE CK+AGKD C NF+RV+Q +N+TH+YVCG+GAF P+C Y++ G
Sbjct: 88 SVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRR 147
Query: 164 KEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTH 223
ED +F +D+ ESG+ +C F+P SVM +E L+SG DF+G D A RSL
Sbjct: 148 SEDQVFMIDS-KCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTK-- 204
Query: 224 DHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVG 283
+ +RTD WL+ F+ IPD +P+D K+YFFF+E + + S K I S +
Sbjct: 205 -RNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIA 263
Query: 284 RVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYG 343
R+C ND GG RSL+NKWTTFLKARL+CS+ DG +T+FDEL+D++LL T + R +VYG
Sbjct: 264 RICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYG 323
Query: 344 VFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTY 403
+FTT+SS+FKGSAVCVY ++DI+ VFNGP+AHKE +H+ + Y GRIPYPRPGTCP +
Sbjct: 324 IFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAF 383
Query: 404 DPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQ 463
P +++T++FPDDV++FI+ H +MY S+YP+ P RI DY+ T+I VD V A DG+
Sbjct: 384 TPNMRTTKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGR 443
Query: 464 YDVMFLGTDIGTVLKVVSISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSR 523
Y V+FLGTD GTV KVV + E++LEEL++FK+ + I M++S K+QQLY+ S
Sbjct: 444 YHVLFLGTDRGTVQKVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSKKQQLYVSSN 503
Query: 524 DGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKYGDPITQ 583
+G+ Q+SLHRC YG ACADCCLARDPYCAWDG++CSR+ PT KRR+RRQDV++G+P+TQ
Sbjct: 504 EGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQ 563
Query: 584 CWDIEDSISHETADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERI 643
C + ++ A E V +G++ N+TFLEC PKS QA+IKW +Q+ D R+E+K +ERI
Sbjct: 564 CRGF-NLKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQKDKD-RRKEVKLNERI 621
Query: 644 IKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEHEEGKVK 703
I T GLLIRS+Q D G+Y+C A E++F TI K+ V+++E M +
Sbjct: 622 IATSQGLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDSE-MVAVVTDKWSPWTWA 680
Query: 704 DLLAESRLRYKDYIQILSSPNFS-LDQYCE---QMWHREKRRQRNKGG-PKWKHMQEMKK 758
+ KD + S ++QYC+ Q + Q+ +G K K + +K
Sbjct: 681 SSVRALPFHPKDIMGAFSHSEMQMINQYCKDTRQQHQQGDESQKMRGDYGKLKALINSRK 740
Query: 759 KRNRRH 764
RNRR+
Sbjct: 741 SRNRRN 746
>gi|9910362 semaphorin sem2 [Homo sapiens]
Length = 782
Score = 653 bits (1685), Expect = 0.0
Identities = 344/760 (45%), Positives = 491/760 (64%), Gaps = 34/760 (4%)
Query: 41 NIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNK 100
++PRL+L+Y+DLL +N FLG L+ Q + LDE R RL LG D ++ L L
Sbjct: 29 SVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWP 88
Query: 101 NFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDL 160
+ +++ WP + E C G+D TECANF+RVLQP+N+TH+ CGTGAF P C I +
Sbjct: 89 DPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALITV 148
Query: 161 GVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLG 220
G ++ + + L+ ++ESGR +CP +P +PFAS D LY+G +DFLG++ RS G
Sbjct: 149 G-HRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGG 207
Query: 221 PTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRES--SQEGSTSDKTI 278
P +R+D S+ L+ +F+ IP+ + D+DK+YFFF E+ S +G ++ T+
Sbjct: 208 P---RPALRSD-SDQSLLHDPRFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTV 263
Query: 279 LSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERN 338
SRVGRVC ND GGQR L+NKW+TFLKARL+CS+PG GA+T+FD+L+D++LL + ++
Sbjct: 264 -SRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKS 322
Query: 339 PVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTC 398
VY +F+T S++F+G AVCVY MADI VFNGP+AH++ H+W Y G++P+PRPG C
Sbjct: 323 LEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVC 382
Query: 399 PSK-TYDP--LIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVD 455
PSK T P ST+D+PD+V+ F + H +M+ V P G P + ++ +L QIVVD
Sbjct: 383 PSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVD 442
Query: 456 HVIAEDGQYDVMFLGTDIGTVLKVVSI-SKEKWNMEEVVLEELQIFKHSSIILNMELSLK 514
V AEDG YDV+FLGTD G+VLKV+++ + EEVVLEELQ+FK + I ME+S+K
Sbjct: 443 RVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVK 502
Query: 515 QQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPT-SKRRARRQ 573
+Q LY+GSR G+ QL LH+C+TYG ACA+CCLARDPYCAWDG +C+ Y P+ KRR RRQ
Sbjct: 503 RQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQ 562
Query: 574 DVKYGDPITQCW---DIEDSISHETADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSG 630
D+++G+P QC E+++ A +++G E NSTFLEC+PKS QA ++W +QR G
Sbjct: 563 DIRHGNPALQCLGQSQEEEAVGLVAA--TMVYGTEHNSTFLECLPKSPQAAVRWLLQRPG 620
Query: 631 DEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQME 690
DE +++K DER++ TE GLL R L + D+G Y C EH F T+V+L L VI Q++
Sbjct: 621 DEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLD 680
Query: 691 N--TQRAEHEEGKVKDLLAES--RLRYKDYIQILSSPNF-SLDQYCEQMW---------- 735
N + EE + LA + + YKD +Q++ N +D+YCE++W
Sbjct: 681 NLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLPRVDEYCERVWCRGTTECSGC 740
Query: 736 HREKRRQRNKGGPKWKHMQEMKKKRNRRHHRDLDELPRAV 775
R + R + G W + E+ KK R H + + PR V
Sbjct: 741 FRSRSRGKQARGKSWAGL-ELGKKMKSRVHAEHNRTPREV 779
>gi|157388902 semaphorin 4C [Homo sapiens]
Length = 833
Score = 338 bits (868), Expect = 9e-93
Identities = 193/494 (39%), Positives = 281/494 (56%), Gaps = 28/494 (5%)
Query: 69 DFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTEC 128
DF TL L E G L +GA++ +F S+ L I W A E+ C GK+ TEC
Sbjct: 52 DFLTLTLTEPTGLLYVGAREALFAFSMEALELQ-GAISWEAPVEKKTECIQKGKNNQTEC 110
Query: 129 ANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQ 188
NFIR LQPYN +H+YVCGT AF P C Y+++ + F L+ E G+ KCP+DP
Sbjct: 111 FNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPA 164
Query: 189 QPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFF 248
+ A ++ D LYS T ++FLG + R++GP HH ++T+ +WLN F+G+ +
Sbjct: 165 KGHAGLLVDGELYSATLNNFLGTEPIILRNMGP---HHSMKTEYLA-FWLNEPHFVGSAY 220
Query: 249 IPDT---YNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLK 305
+P++ + DDDK+YFFFRE + E + +++RV RVCK D+GG R+L KWTTFLK
Sbjct: 221 VPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLK 280
Query: 306 ARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADI 365
ARL CS P YF++LQ ++ L N +GVF SA+C Y + +I
Sbjct: 281 ARLACSAP---NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEI 337
Query: 366 RAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPL-IKSTRDFPDDVISFIKRH 424
+ VF GPY +W +Y +P PRPG+C + + S+ + PD++++F+K+H
Sbjct: 338 QRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKH 397
Query: 425 SVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDG-QYDVMFLGTDIGTVLKVVSIS 483
+M + V P P + ++ T +V D V DG Y V+F+GT G +LK VS+
Sbjct: 398 PLMEEQVGPRWSRPLLVKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLG 455
Query: 484 KEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACAD 543
W ++EELQ+F + ++ LS ++ L+ GSR LVQL + C Y ++CAD
Sbjct: 456 --PW---VHLIEELQLFDQEP-MRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCAD 508
Query: 544 CCLARDPYCAWDGN 557
C LARDPYCAW N
Sbjct: 509 CVLARDPYCAWSVN 522
>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
Length = 862
Score = 332 bits (851), Expect = 8e-91
Identities = 228/675 (33%), Positives = 348/675 (51%), Gaps = 60/675 (8%)
Query: 18 LFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDE 77
L +M M F P IPR+ ++++ L P + ++ LLL E
Sbjct: 11 LMALAVMFGTAMAFAP--------IPRITWEHREVHLVQFHEPDI-----YNYSALLLSE 57
Query: 78 ERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQP 137
++ L +GA++ +F ++ +++++ ++YW ++++ C GK TEC N+IRVLQP
Sbjct: 58 DKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQP 117
Query: 138 YNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTD 197
+ T +YVCGT AF P C +++L FK N E G+ +CPFDP + SVM D
Sbjct: 118 LSATSLYVCGTNAFQPACDHLNL------TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVD 170
Query: 198 EYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFI---PDTYN 254
LYSGT+ +FLG + +R+ H +RT+ + WLN F+ I PD+ +
Sbjct: 171 GELYSGTSYNFLGSEPIISRN----SSHSPLRTEYAIP-WLNEPSFVFADVIRKSPDSPD 225
Query: 255 PDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPG 314
+DD++YFFF E S E + ++ R+ RVCK D GG R+L KWT+FLKARLICS P
Sbjct: 226 GEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPD 285
Query: 315 SDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVF-NGPY 373
S F+ L+D+++L + + PV Y +FT + SAVC Y+++ VF +G Y
Sbjct: 286 S---GLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKY 342
Query: 374 AHK---ESADHRWVQYDGRIPYPRPGTC-PSKTYDPLIKSTRDFPDDVISFIKRHSVMYK 429
E + +WV+Y+G +P PRPG C S+ S+ + PD + F+K H +M
Sbjct: 343 MQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDD 402
Query: 430 SVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQ-YDVMFLGTDIGTVLKVVSISKEKWN 488
SV P+ P + +V+Y TQIVVD A DG YDVMF+ TD G + K +S+
Sbjct: 403 SVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH- 459
Query: 489 MEEVVLEELQIFKHSSIILNMELSLKQ--QQLYIGSRDGLVQLSLHRCDTYGKACADCCL 546
++EE Q+F+ + + LS K+ + +Y GS G+VQ L C +G C DC L
Sbjct: 460 ----IIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVL 514
Query: 547 ARDPYCAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETA--DEKVIFGI 604
ARDPYCAW PT+ A Q + Q + S+ + + + F
Sbjct: 515 ARDPYCAWS-------PPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFK 567
Query: 605 EFNSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYY 664
+ L+C KS A + W Q +G E K + LLI +L + DSG+Y
Sbjct: 568 HGGTAELKCSQKSNLARVFWKFQ-NGVLKAESPKYG---LMGRKNLLIFNLSEGDSGVYQ 623
Query: 665 CKAQEHTFIHTIVKL 679
C ++E T+ ++
Sbjct: 624 CLSEERVKNKTVFQV 638
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 327 bits (839), Expect = 2e-89
Identities = 222/662 (33%), Positives = 335/662 (50%), Gaps = 61/662 (9%)
Query: 43 PRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKN- 101
PR+ + Y++L + F G ++ ++ TLLL+E RLL+GA+ +F LS D+
Sbjct: 34 PRMTIPYEEL---SGTRHFKGQAQ--NYSTLLLEEASARLLVGARGALFSLSANDIGDGA 88
Query: 102 FKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLG 161
K+I+W A+ E C GK+ TEC N +R LQ N TH+Y CGT AF P+C ID
Sbjct: 89 HKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAE 148
Query: 162 VYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGP 221
F L T + E G+ KCP+DP + F ++ D LY+ T +F RS P
Sbjct: 149 A------FTLPT-SFEEGKEKCPYDPARGFTGLIIDGGLYTATRYEFRSIPD-IRRSRHP 200
Query: 222 THDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNP---DDDKIYFFFRE-SSQEGSTS--- 274
H +RT+ + +WLN A+F+ + + ++ DDDK+Y+FF E +++EGS S
Sbjct: 201 ----HSLRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQ 256
Query: 275 --DKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLP 332
++RV RVCK D+GG++ L KWT+FLKARLIC IP ++ L+ + L
Sbjct: 257 SRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-------LYETLRGVCSLD 309
Query: 333 TRDERNPVVYGVFT--TTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRI 390
Y FT T + SA+C Y +A+I+AVF GPY + RW +Y+G +
Sbjct: 310 AETSSRTHFYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGV 369
Query: 391 PYPRPGTCPSKTY-DPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRL 449
P PRPG+C + + S++D P V+ F+K H +M + V P G P + N+ Y
Sbjct: 370 PEPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRY-- 427
Query: 450 TQIVVDHVIAEDG-QYDVMFLGTDIGTVLKVVSISKEKWNMEEVVLEELQIFKHSSIILN 508
T + V G YD++FLGT G + K V + ++EE Q+F+ S + N
Sbjct: 428 THLTGTPVTTPAGPTYDLLFLGTADGWIHKAVVLGSGMH-----IIEETQVFRESQSVEN 482
Query: 509 MELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPTS-- 566
+ +SL Q LY+G+ G++QL L C Y ++C DC LARDPYC WD + A T+
Sbjct: 483 LVISLLQHSLYVGAPSGVIQLPLSSCSRY-RSCYDCILARDPYCGWDPGTHACAAATTIA 541
Query: 567 -----KRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFLECIPKSQQAT 621
R A QD++ G+ C D+ + + + + L C S A
Sbjct: 542 NRSQGSRTALIQDIERGN--RGCESSRDTGPPPPLKTRSV--LRGDDVLLPCDQPSNLAR 597
Query: 622 IKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTL 681
W + +G + + R+ GLL+ Q + SG Y C A+E+ + +L
Sbjct: 598 ALWLL--NGSMGLSDGQGGYRV--GVDGLLVTDAQPEHSGNYGCYAEENGLRTLLASYSL 653
Query: 682 NV 683
V
Sbjct: 654 TV 655
>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
Length = 738
Score = 322 bits (826), Expect = 6e-88
Identities = 200/548 (36%), Positives = 300/548 (54%), Gaps = 47/548 (8%)
Query: 18 LFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDE 77
L +M M F P IPR+ ++++ L P + ++ LLL E
Sbjct: 11 LMALAVMFGTAMAFAP--------IPRITWEHREVHLVQFHEPDI-----YNYSALLLSE 57
Query: 78 ERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQP 137
++ L +GA++ +F ++ +++++ ++YW ++++ C GK TEC N+IRVLQP
Sbjct: 58 DKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQP 117
Query: 138 YNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTD 197
+ T +YVCGT AF P C +++L FK N E G+ +CPFDP + SVM D
Sbjct: 118 LSATSLYVCGTNAFQPACDHLNL------TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVD 170
Query: 198 EYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFI---PDTYN 254
LYSGT+ +FLG + +R+ H +RT+ + WLN F+ I PD+ +
Sbjct: 171 GELYSGTSYNFLGSEPIISRN----SSHSPLRTEYAIP-WLNEPSFVFADVIRKSPDSPD 225
Query: 255 PDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPG 314
+DD++YFFF E S E + ++ R+ RVCK D GG R+L KWT+FLKARLICS P
Sbjct: 226 GEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPD 285
Query: 315 SDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVF-NGPY 373
S F+ L+D+++L + + PV Y +FT + SAVC Y+++ VF +G Y
Sbjct: 286 S---GLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKY 342
Query: 374 AHK---ESADHRWVQYDGRIPYPRPGTC-PSKTYDPLIKSTRDFPDDVISFIKRHSVMYK 429
E + +WV+Y+G +P PRPG C S+ S+ + PD + F+K H +M
Sbjct: 343 MQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDD 402
Query: 430 SVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQ-YDVMFLGTDIGTVLKVVSISKEKWN 488
SV P+ P + +V+Y TQIVVD A DG YDVMF+ TD G + K +S+
Sbjct: 403 SVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH- 459
Query: 489 MEEVVLEELQIFKHSSIILNMELSLKQ--QQLYIGSRDGLVQLSLHRCDTYGKACADCCL 546
++EE Q+F+ + + LS K+ + +Y GS G+VQ L C +G C DC L
Sbjct: 460 ----IIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVL 514
Query: 547 ARDPYCAW 554
ARDPYCAW
Sbjct: 515 ARDPYCAW 522
>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
Length = 597
Score = 315 bits (806), Expect = 1e-85
Identities = 191/550 (34%), Positives = 286/550 (52%), Gaps = 41/550 (7%)
Query: 64 SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKL 119
S LDFQ +L + R L + +D ++ ++L ++ K KK+ W + ++ E C +
Sbjct: 53 SQHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAM 110
Query: 120 AGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESG 179
GK + EC NFI+V P N ++VCGT AF+P+C Y L + D SG
Sbjct: 111 KGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYD-------GEEISG 162
Query: 180 RLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLN 239
+CPFD +Q ++ D LYS T +DFL D RS+G D +RT + W+
Sbjct: 163 LARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMG---DGSALRTIKYDSKWIK 219
Query: 240 GAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINK 299
F+ + +YFFFRE + E + K + SRV R+CKND+GG + ++ K
Sbjct: 220 EPHFLHAIEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEK 272
Query: 300 -WTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVC 358
WT+FLKARL CS+PG + YFD LQ I + + P V GVFTT + GSAVC
Sbjct: 273 HWTSFLKARLNCSVPGD--SFFYFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVC 329
Query: 359 VYSMADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTYDPLIKSTRDFPDDV 417
+SM DI VF G + +++ D W + ++P PRPG C K++ DFPD+
Sbjct: 330 AFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDET 389
Query: 418 ISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVL 477
+SFIK H +M +V P+A P F + V YRLT I VDH Y V+F+G++ G VL
Sbjct: 390 LSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVL 449
Query: 478 KVVSISKEKWNMEEVVLEELQIFKHSSI---------ILNMELSLKQQQLYIGSRDGLVQ 528
KV++ + + V+LEE++ + H+ +++++L LY+ +++
Sbjct: 450 KVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIR 509
Query: 529 LSLHRCDTYGKACADCCLARDPYCAW-DGNACSRYAPTSKRRARRQDVKYGDP--ITQCW 585
+ L RC+ YG C +RDPYC W +C R P QD ++G+ + C
Sbjct: 510 IPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCH 569
Query: 586 DIEDSISHET 595
D+E S S T
Sbjct: 570 DMEVSSSSVT 579
>gi|39777610 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 313 bits (803), Expect = 3e-85
Identities = 238/717 (33%), Positives = 353/717 (49%), Gaps = 67/717 (9%)
Query: 20 PALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLG-SSEGLDFQTLLLDEE 78
P L++L + +L P T + PR+ L L + PFL +E + T LL
Sbjct: 24 PLLLLLLLLLLLQPPPPTWALS-PRISLP-----LGSEERPFLRFEAEHISNYTALLLSR 77
Query: 79 RGRLL-LGAKDHIFLLS--LVDL-NKNFKKIYWPAAKERVELCKLAGKDANTECANFIRV 134
GR L +GA++ +F LS L L ++++ W A E+ + C GKD +C N+I++
Sbjct: 78 DGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKI 137
Query: 135 LQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHN---LESGRLKCPFDPQQPF 191
L P + +H++ CGT AF P+C YI++ E+ D LE G+ +CPFDP
Sbjct: 138 LLPLSGSHLFTCGTAAFSPMCTYINM----ENFTLARDEKGNVLLEDGKGRCPFDPNFKS 193
Query: 192 ASVMTDEYLYSGTASDFLGKDTAFTRS--LGPTHDHHYIRTDISEHYWLNGAKFIGTFFI 249
+++ D LY+GT S F G D A +RS L PT +T+ S + WL F+ + +I
Sbjct: 194 TALVVDGELYTGTVSSFQGNDPAISRSQSLRPT------KTESSLN-WLQDPAFVASAYI 246
Query: 250 PDTYNP---DDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKA 306
P++ DDDKIYFFF E+ QE + TI+SR+ R+CK D GG+R L +WT+FLKA
Sbjct: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKA 306
Query: 307 RLICSIPGSDGADTYFDELQDIYLL--PTRDERNPVVYGVFTTT--SSIFKGSAVCVYSM 362
+L+CS P DG F+ LQD++ L +D R+ + YGVFT+ +GSAVCV++M
Sbjct: 307 QLLCSRP-DDGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
Query: 363 ADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTC-PSKTYDPLIKSTRDFPDDVISFI 421
D++ VF+G Y +W +P PRPG C + + I S+ PD V++F+
Sbjct: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
Query: 422 KRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVS 481
K H +M V + R ++ V V YDV+FLGT G + K VS
Sbjct: 424 KDHFLMDGQV-----RSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS 478
Query: 482 ISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKAC 541
+ ++EELQIF + N+ L + LY S G+VQ+ + C Y ++C
Sbjct: 479 VGPRVH-----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSC 532
Query: 542 ADCCLARDPYCAWDGNAC---SRYAPTSKRRARRQDVKYGDPITQC-WDIEDSISHETAD 597
DC LARDPYCAW G++C S Y P R QD++ C S S
Sbjct: 533 GDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTG 592
Query: 598 EKVIFGIEFNS---TFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRS 654
EK ++F L C S AT W R+G ++ T LL+ +
Sbjct: 593 EKPCEQVQFQPNTVNTLACPLLSNLATRLWL--RNGAP--VNASASCHVLPTGDLLLVGT 648
Query: 655 LQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEHEEGKVKDLLAESRL 711
Q G + C + E F + V+E+ + T E G V +++ SR+
Sbjct: 649 QQ---LGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTD----EGGSVPVIISTSRV 698
>gi|39777608 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 313 bits (803), Expect = 3e-85
Identities = 238/717 (33%), Positives = 353/717 (49%), Gaps = 67/717 (9%)
Query: 20 PALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLG-SSEGLDFQTLLLDEE 78
P L++L + +L P T + PR+ L L + PFL +E + T LL
Sbjct: 24 PLLLLLLLLLLLQPPPPTWALS-PRISLP-----LGSEERPFLRFEAEHISNYTALLLSR 77
Query: 79 RGRLL-LGAKDHIFLLS--LVDL-NKNFKKIYWPAAKERVELCKLAGKDANTECANFIRV 134
GR L +GA++ +F LS L L ++++ W A E+ + C GKD +C N+I++
Sbjct: 78 DGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKI 137
Query: 135 LQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHN---LESGRLKCPFDPQQPF 191
L P + +H++ CGT AF P+C YI++ E+ D LE G+ +CPFDP
Sbjct: 138 LLPLSGSHLFTCGTAAFSPMCTYINM----ENFTLARDEKGNVLLEDGKGRCPFDPNFKS 193
Query: 192 ASVMTDEYLYSGTASDFLGKDTAFTRS--LGPTHDHHYIRTDISEHYWLNGAKFIGTFFI 249
+++ D LY+GT S F G D A +RS L PT +T+ S + WL F+ + +I
Sbjct: 194 TALVVDGELYTGTVSSFQGNDPAISRSQSLRPT------KTESSLN-WLQDPAFVASAYI 246
Query: 250 PDTYNP---DDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKA 306
P++ DDDKIYFFF E+ QE + TI+SR+ R+CK D GG+R L +WT+FLKA
Sbjct: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKA 306
Query: 307 RLICSIPGSDGADTYFDELQDIYLL--PTRDERNPVVYGVFTTT--SSIFKGSAVCVYSM 362
+L+CS P DG F+ LQD++ L +D R+ + YGVFT+ +GSAVCV++M
Sbjct: 307 QLLCSRP-DDGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
Query: 363 ADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTC-PSKTYDPLIKSTRDFPDDVISFI 421
D++ VF+G Y +W +P PRPG C + + I S+ PD V++F+
Sbjct: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
Query: 422 KRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVS 481
K H +M V + R ++ V V YDV+FLGT G + K VS
Sbjct: 424 KDHFLMDGQV-----RSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS 478
Query: 482 ISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKAC 541
+ ++EELQIF + N+ L + LY S G+VQ+ + C Y ++C
Sbjct: 479 VGPRVH-----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSC 532
Query: 542 ADCCLARDPYCAWDGNAC---SRYAPTSKRRARRQDVKYGDPITQC-WDIEDSISHETAD 597
DC LARDPYCAW G++C S Y P R QD++ C S S
Sbjct: 533 GDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTG 592
Query: 598 EKVIFGIEFNS---TFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRS 654
EK ++F L C S AT W R+G ++ T LL+ +
Sbjct: 593 EKPCEQVQFQPNTVNTLACPLLSNLATRLWL--RNGAP--VNASASCHVLPTGDLLLVGT 648
Query: 655 LQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEHEEGKVKDLLAESRL 711
Q G + C + E F + V+E+ + T E G V +++ SR+
Sbjct: 649 QQ---LGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTD----EGGSVPVIISTSRV 698
>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
Length = 1073
Score = 313 bits (802), Expect = 4e-85
Identities = 190/556 (34%), Positives = 286/556 (51%), Gaps = 40/556 (7%)
Query: 64 SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKL 119
S LDFQ +L + R L + +D ++ ++L ++ K KK+ W + ++ E C +
Sbjct: 53 SQHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAM 110
Query: 120 AGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESG 179
GK + EC NFI+V P N ++VCGT AF+P+C Y L + D SG
Sbjct: 111 KGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYD-------GEEISG 162
Query: 180 RLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLN 239
+CPFD +Q ++ D LYS T +DFL D RS+G D +RT + W+
Sbjct: 163 LARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMG---DGSALRTIKYDSKWIK 219
Query: 240 GAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINK 299
F+ + +YFFFRE + E + K + SRV R+CKND+GG + ++ K
Sbjct: 220 EPHFLHAIEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEK 272
Query: 300 -WTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVC 358
WT+FLKARL CS+PG + YFD LQ I + + P V GVFTT + GSAVC
Sbjct: 273 HWTSFLKARLNCSVPGD--SFFYFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVC 329
Query: 359 VYSMADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTYDPLIKSTRDFPDDV 417
+SM DI VF G + +++ D W + ++P PRPG C K++ DFPD+
Sbjct: 330 AFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDET 389
Query: 418 ISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVL 477
+SFIK H +M +V P+A P F + V YRLT I VDH Y V+F+G++ G VL
Sbjct: 390 LSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVL 449
Query: 478 KVVSISKEKWNMEEVVLEELQIFKHSSI---------ILNMELSLKQQQLYIGSRDGLVQ 528
KV++ + + V+LEE++ + H+ +++++L LY+ +++
Sbjct: 450 KVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIR 509
Query: 529 LSLHRCDTYGKACADCCLARDPYCAW-DGNACSRYAPTSKRRARRQDVKYGDPITQCWDI 587
+ L RC+ YG C +RDPYC W +C R P QD ++G+ D
Sbjct: 510 IPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGN-TAHLGDC 568
Query: 588 EDSISHETADEKVIFG 603
+ + T + IFG
Sbjct: 569 HEILPTSTTPDYKIFG 584
>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
Length = 1017
Score = 313 bits (802), Expect = 4e-85
Identities = 190/556 (34%), Positives = 286/556 (51%), Gaps = 40/556 (7%)
Query: 64 SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKL 119
S LDFQ +L + R L + +D ++ ++L ++ K KK+ W + ++ E C +
Sbjct: 53 SQHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAM 110
Query: 120 AGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESG 179
GK + EC NFI+V P N ++VCGT AF+P+C Y L + D SG
Sbjct: 111 KGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYD-------GEEISG 162
Query: 180 RLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLN 239
+CPFD +Q ++ D LYS T +DFL D RS+G D +RT + W+
Sbjct: 163 LARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMG---DGSALRTIKYDSKWIK 219
Query: 240 GAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINK 299
F+ + +YFFFRE + E + K + SRV R+CKND+GG + ++ K
Sbjct: 220 EPHFLHAIEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEK 272
Query: 300 -WTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVC 358
WT+FLKARL CS+PG + YFD LQ I + + P V GVFTT + GSAVC
Sbjct: 273 HWTSFLKARLNCSVPGD--SFFYFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVC 329
Query: 359 VYSMADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTYDPLIKSTRDFPDDV 417
+SM DI VF G + +++ D W + ++P PRPG C K++ DFPD+
Sbjct: 330 AFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDET 389
Query: 418 ISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVL 477
+SFIK H +M +V P+A P F + V YRLT I VDH Y V+F+G++ G VL
Sbjct: 390 LSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVL 449
Query: 478 KVVSISKEKWNMEEVVLEELQIFKHSSI---------ILNMELSLKQQQLYIGSRDGLVQ 528
KV++ + + V+LEE++ + H+ +++++L LY+ +++
Sbjct: 450 KVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIR 509
Query: 529 LSLHRCDTYGKACADCCLARDPYCAW-DGNACSRYAPTSKRRARRQDVKYGDPITQCWDI 587
+ L RC+ YG C +RDPYC W +C R P QD ++G+ D
Sbjct: 510 IPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGN-TAHLGDC 568
Query: 588 EDSISHETADEKVIFG 603
+ + T + IFG
Sbjct: 569 HEILPTSTTPDYKIFG 584
>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
Length = 998
Score = 313 bits (801), Expect = 5e-85
Identities = 190/565 (33%), Positives = 290/565 (51%), Gaps = 45/565 (7%)
Query: 64 SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKL 119
S LDFQ +L + R L + +D ++ ++L ++ K KK+ W + ++ E C +
Sbjct: 53 SQHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAM 110
Query: 120 AGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESG 179
GK + EC NFI+V P N ++VCGT AF+P+C Y L + D SG
Sbjct: 111 KGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYD-------GEEISG 162
Query: 180 RLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLN 239
+CPFD +Q ++ D LYS T +DFL D RS+G D +RT + W+
Sbjct: 163 LARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMG---DGSALRTIKYDSKWIK 219
Query: 240 GAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINK 299
F+ + +YFFFRE + E + K + SRV R+CKND+GG + ++ K
Sbjct: 220 EPHFLHAIEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEK 272
Query: 300 -WTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVC 358
WT+FLKARL CS+PG + YFD LQ I + + P V GVFTT + GSAVC
Sbjct: 273 HWTSFLKARLNCSVPGD--SFFYFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVC 329
Query: 359 VYSMADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTYDPLIKSTRDFPDDV 417
+SM DI VF G + +++ D W + ++P PRPG C K++ DFPD+
Sbjct: 330 AFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDET 389
Query: 418 ISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVL 477
+SFIK H +M +V P+A P F + V YRLT I VDH Y V+F+G++ G VL
Sbjct: 390 LSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVL 449
Query: 478 KVVSISKEKWNMEEVVLEELQIFKHSSI---------ILNMELSLKQQQLYIGSRDGLVQ 528
KV++ + + V+LEE++ + H+ +++++L LY+ +++
Sbjct: 450 KVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIR 509
Query: 529 LSLHRCDTYGKACADCCLARDPYCAW-DGNACSRYAPTSKRRARRQDVKYGDP--ITQC- 584
+ L RC+ YG C +RDPYC W +C R P QD ++G+ + C
Sbjct: 510 IPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCH 569
Query: 585 ---WDIEDSISHETADEKVIFGIEF 606
W+++ S++ V+ F
Sbjct: 570 GVRWEVQSGESNQMVHMNVLITCVF 594
>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
Length = 1011
Score = 305 bits (782), Expect = 8e-83
Identities = 182/517 (35%), Positives = 272/517 (52%), Gaps = 39/517 (7%)
Query: 64 SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKL 119
S LDFQ +L + R L + +D ++ ++L ++ K KK+ W + ++ E C +
Sbjct: 53 SQHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAM 110
Query: 120 AGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESG 179
GK + EC NFI+V P N ++VCGT AF+P+C Y L + D SG
Sbjct: 111 KGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYD-------GEEISG 162
Query: 180 RLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLN 239
+CPFD +Q ++ D LYS T +DFL D RS+G D +RT + W+
Sbjct: 163 LARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMG---DGSALRTIKYDSKWIK 219
Query: 240 GAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINK 299
F+ + +YFFFRE + E + K + SRV R+CKND+GG + ++ K
Sbjct: 220 EPHFLHAIEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEK 272
Query: 300 -WTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVC 358
WT+FLKARL CS+PG + YFD LQ I + + P V GVFTT + GSAVC
Sbjct: 273 HWTSFLKARLNCSVPGD--SFFYFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVC 329
Query: 359 VYSMADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTYDPLIKSTRDFPDDV 417
+SM DI VF G + +++ D W + ++P PRPG C K++ DFPD+
Sbjct: 330 AFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDET 389
Query: 418 ISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVL 477
+SFIK H +M +V P+A P F + V YRLT I VDH Y V+F+G++ G VL
Sbjct: 390 LSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVL 449
Query: 478 KVVSISKEKWNMEEVVLEELQIFKHSSI---------ILNMELSLKQQQLYIGSRDGLVQ 528
KV++ + + V+LEE++ + H+ +++++L LY+ +++
Sbjct: 450 KVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIR 509
Query: 529 LSLHRCDTYGKACADCCLARDPYCAW-DGNACSRYAP 564
+ L RC+ YG C +RDPYC W +C R P
Sbjct: 510 IPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTP 546
>gi|19923279 semaphorin W [Homo sapiens]
Length = 770
Score = 296 bits (759), Expect = 4e-80
Identities = 207/668 (30%), Positives = 324/668 (48%), Gaps = 55/668 (8%)
Query: 24 MLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLL 83
+L + +L PV+G + +++PR L + ++SC+ ++ LL+D L
Sbjct: 22 LLLLAVLSGPVSGRVPRSVPRTSLPISE---ADSCLTRFAVPHTYNYSVLLVDPASHTLY 78
Query: 84 LGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHI 143
+GA+D IF LSL + ++I W + + C+ GK + EC NF+++L N +H+
Sbjct: 79 VGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED-ECHNFVQILAIANASHL 137
Query: 144 YVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSG 203
CGT AF P CG ID+ +++ LESGR KCPF+P Q A+VM LY+
Sbjct: 138 LTCGTFAFDPKCGVIDVSRFQQ-------VERLESGRGKCPFEPAQRSAAVMAGGVLYAA 190
Query: 204 TASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPD---DDKI 260
T ++LG + TR++G D +IRTD WLN F+ + D DD+I
Sbjct: 191 TVKNYLGTEPIITRAVGRAED--WIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEI 247
Query: 261 YFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADT 320
YFFF E+S+ + ++ + RV RVC D+GG+++L +WTTFLKA L+C P A +
Sbjct: 248 YFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASS 307
Query: 321 YFDELQDIYLL-PTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAH-KES 378
LQD+ +L P P+ YG+F++ SAVC + DIR V NGP+ K
Sbjct: 308 V---LQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHD 364
Query: 379 ADHRWVQYDGRIPYPRPGTCPSKTYD-PLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGG 437
+ D +P PRPG C + S+ PD V++FI+ H +M + V+P G
Sbjct: 365 CNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGH 424
Query: 438 PTFKRINVDYRLTQIVVDHVIAEDG-QYDVMFLGTDIGTVLKVVSISKEKWNMEEVVLEE 496
P + D ++V V + G +YDV++LGT+ G + + V I + VLE+
Sbjct: 425 PLL--VTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQL-----SVLED 477
Query: 497 LQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDG 556
L +F + NM+ L L +GSR + Q++ C ++C++C LA+DP CAW
Sbjct: 478 LALFPEPQPVENMK--LYHSWLLVGSRTEVTQVNTTNCGRL-QSCSECILAQDPVCAWSF 534
Query: 557 NACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNS---TFLEC 613
A + R QD++ D + C E + V+F + + L C
Sbjct: 535 RLDECVAHAGEHRGLVQDIESADVSSLC-------PKEPGERPVVFEVPVATAAHVVLPC 587
Query: 614 IPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFI 673
P S A+ W+ Q SG + ++ T + G Y C+ QE
Sbjct: 588 SPSSAWASCVWH-QPSGVTALTPRRDGLEVVVTPGAM----------GAYACECQEGGAA 636
Query: 674 HTIVKLTL 681
H + +L
Sbjct: 637 HVVAAYSL 644
>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
domain, (semaphorin) 6A [Homo sapiens]
Length = 1030
Score = 289 bits (739), Expect = 8e-78
Identities = 186/533 (34%), Positives = 275/533 (51%), Gaps = 48/533 (9%)
Query: 68 LDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKN----FKKIYWPAAKERVELCKLAGKD 123
LD Q +++ G L + A+DHI+ + + + KK+ W + + V+ C++ GK
Sbjct: 56 LDIQMIMI--MNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKH 113
Query: 124 ANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKC 183
+ EC NFI+VL N ++VCGT AF+P C YK D + SG +C
Sbjct: 114 KD-ECHNFIKVLLKKNDDALFVCGTNAFNPSCRN-----YKMDTLEPFGDEF--SGMARC 165
Query: 184 PFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKF 243
P+D + ++ D LYS T +DFL D RSLG + +RT + WL F
Sbjct: 166 PYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPT---LRTVKHDSKWLKEPYF 222
Query: 244 IGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGG-QRSLINKWTT 302
+ D IYFFFRE + E +T K + RV +VCKND+GG QR L +WT+
Sbjct: 223 VQAVDY-------GDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTS 275
Query: 303 FLKARLICSIPGSDGADTYFDELQ---DIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCV 359
FLKARL CS+PG + YF+ LQ D+ + RD VV F+T + GSAVC
Sbjct: 276 FLKARLNCSVPGD--SHFYFNILQAVTDVIRINGRD----VVLATFSTPYNSIPGSAVCA 329
Query: 360 YSMADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVI 418
Y M DI +VF G + ++S D W D R+P PRPG C + ++ +FPDD +
Sbjct: 330 YDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTL 389
Query: 419 SFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLK 478
+FIK H +M ++V + P F R V YRLT+I VD + V+FLG++ G +LK
Sbjct: 390 NFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILK 449
Query: 479 VVS-ISKEKWNMEEVVLEELQIFKHSSI---------ILNMELSLKQQQLYIGSRDGLVQ 528
++ I + + + LEE+ ++ I+ M+L LY+ +++
Sbjct: 450 FLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIK 509
Query: 529 LSLHRCDTYGKACADCCLARDPYCAW--DGNACSRYAPTSKRRARRQDVKYGD 579
+ L RC+ +GK C +RDPYC W +G ACS +P S R QD++ G+
Sbjct: 510 VPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNS-RLTFEQDIERGN 561
>gi|21361914 semaphorin B [Homo sapiens]
Length = 761
Score = 288 bits (737), Expect = 1e-77
Identities = 207/672 (30%), Positives = 320/672 (47%), Gaps = 67/672 (9%)
Query: 22 LMMLSMTMLFLPVT---GTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEE 78
L + + L LP T G + +PR++ D + F DF TLLL +
Sbjct: 16 LFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGD---ERRALSFFHQKGLQDFDTLLLSGD 72
Query: 79 RGRLLLGAKDHIFLLSLVD--LNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQ 136
L +GA++ I L + D + + I WPA+ + C K T+C NFIRVL
Sbjct: 73 GNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLV 132
Query: 137 PYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMT 196
YN TH+Y CGT AF P C +I+L ++ + + + G+ + PFDP +V+
Sbjct: 133 SYNVTHLYTCGTFAFSPACTFIEL---QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLV 189
Query: 197 DEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPD 256
D LYSGT ++FLG + R+LG ++TD + + A F+ P
Sbjct: 190 DGMLYSGTMNNFLGSEPILMRTLG---SQPVLKTDNFLRWLHHDASFVAAI-------PS 239
Query: 257 DDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSD 316
+YFFF E++ E ++ SRV RVCKNDVGG++ L KWTTFLKA+L+C+ PG
Sbjct: 240 TQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPG-- 297
Query: 317 GADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSI--FKGSAVCVYSMADIRAVFNGPYA 374
F+ ++ LLP P +Y VFT+ + + SAVC +S+ DI VF G Y
Sbjct: 298 --QLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYK 355
Query: 375 HKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPV 434
RW Y G PRPG+C S D ++F+K H +M + V
Sbjct: 356 ELNKETSRWTTYRGPETNPRPGSC----------SVGPSSDKALTFMKDHFLMDEQ---V 402
Query: 435 AGGPTFKRINVDYRLTQIVVDHVIAEDG-QYDVMFLGTDIGTVLKVVSISKEKWNMEEVV 493
G P + V+Y T++ V+ DG + VM+LGT G++ K V ++
Sbjct: 403 VGTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHL---- 456
Query: 494 LEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCA 553
+EE+Q+F + N++L+ Q +++G G+ ++ C Y ++C DC LARDP+CA
Sbjct: 457 VEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCA 515
Query: 554 WDGNA---CSRYAPTSKRRARRQDVKYGDPITQC--WDIEDSISHETADE--KVIFGIEF 606
WD + C AP + +QD++ G+P C + S+ ++ + K + +
Sbjct: 516 WDPESRTCCLLSAP--NLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPN 573
Query: 607 NSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEY-GLLIRSLQKKDSGMYYC 665
+ L C S A+ W H P+ T Y G L+ +Q G+Y C
Sbjct: 574 SILELPCPHLSALASYYW-------SHGPAAVPEAS--STVYNGSLLLIVQDGVGGLYQC 624
Query: 666 KAQEHTFIHTIV 677
A E+ F + ++
Sbjct: 625 WATENGFSYPVI 636
>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
Length = 476
Score = 270 bits (691), Expect = 3e-72
Identities = 164/446 (36%), Positives = 241/446 (54%), Gaps = 29/446 (6%)
Query: 64 SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKL 119
S LDFQ +L + R L + +D ++ ++L ++ K KK+ W + ++ E C +
Sbjct: 53 SQHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAM 110
Query: 120 AGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESG 179
GK + EC NFI+V P N ++VCGT AF+P+C Y L + D SG
Sbjct: 111 KGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYD-------GEEISG 162
Query: 180 RLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLN 239
+CPFD +Q ++ D LYS T +DFL D RS+G D +RT + W+
Sbjct: 163 LARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMG---DGSALRTIKYDSKWIK 219
Query: 240 GAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINK 299
F+ + +YFFFRE + E + K + SRV R+CKND+GG + ++ K
Sbjct: 220 EPHFLHAIEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEK 272
Query: 300 -WTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVC 358
WT+FLKARL CS+PG + YFD LQ I + + P V GVFTT + GSAVC
Sbjct: 273 HWTSFLKARLNCSVPGD--SFFYFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVC 329
Query: 359 VYSMADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTYDPLIKSTRDFPDDV 417
+SM DI VF G + +++ D W + ++P PRPG C K++ DFPD+
Sbjct: 330 AFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDET 389
Query: 418 ISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVL 477
+SFIK H +M +V P+A P F + V YRLT I VDH Y V+F+G++ G VL
Sbjct: 390 LSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVL 449
Query: 478 KVVSISKEKWNMEEVVLEELQIFKHS 503
KV++ + + V+LEE++ + H+
Sbjct: 450 KVLAKTSPFSLNDSVLLEEIEAYNHA 475
>gi|16306552 semaphorin Y [Homo sapiens]
Length = 930
Score = 266 bits (681), Expect = 4e-71
Identities = 188/564 (33%), Positives = 268/564 (47%), Gaps = 56/564 (9%)
Query: 17 HLFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSE-------GLD 69
H P L++L +L LP T P L L DL ++ F G + GLD
Sbjct: 6 HFMPLLLLL--LLLSLPHTQAAFPQDP-LPLLISDLQGTSPLSWFRGLEDDAVAAELGLD 62
Query: 70 FQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKI---YWPAAKERVELCKLAGKDANT 126
FQ L LL+ A+DH+F L + + Y + VE C + GK
Sbjct: 63 FQRFLTLNRT--LLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRSQDVENCAVRGK-LTD 119
Query: 127 ECANFIRVLQPYNKTHIYVCGTGAFHPIC---GYIDLGVYKEDIIFKLDTHNLESGRLKC 183
EC N+IRVL P++ + CGT +F P+C G L E++ SG+ +C
Sbjct: 120 ECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEEL----------SGQARC 169
Query: 184 PFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKF 243
PFD Q ++ + LYS TA+DF D RSLGP +R+ + WL F
Sbjct: 170 PFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPP---LRSAKYDSKWLREPHF 226
Query: 244 IGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQ-RSLINKWTT 302
+ D +YFFFRE S E + + SRV RVCK D+GG R+L WT+
Sbjct: 227 VQAL-------EHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTS 279
Query: 303 FLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSM 362
FLK RL CS+PG + YFD LQ + P ++GVFTT ++ GSAVC + +
Sbjct: 280 FLKLRLNCSVPGD--STFYFDVLQAL-TGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYL 336
Query: 363 ADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFI 421
+I F G + + S D W + R+P PRPG+C L S+RD PDDV++FI
Sbjct: 337 DEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFI 396
Query: 422 KRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVS 481
K H ++ +V PV P + LTQ+ VD + VMFLG++ GTVLKV++
Sbjct: 397 KAHPLLDPAVPPVTHQPLL-TLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLT 455
Query: 482 ISKEKWNMEEVVLEELQIFKHSSI-----------ILNMELSLKQQQLYIGSRDGLVQLS 530
E ++LEE+ + + I+ +EL + +L++ +V L
Sbjct: 456 PGGRSGGPEPILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLP 515
Query: 531 LHRCDTYGKACADCCLARDPYCAW 554
L RC +G C ++DPYC W
Sbjct: 516 LSRCARHGACQRSCLASQDPYCGW 539
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 249 bits (635), Expect = 9e-66
Identities = 167/512 (32%), Positives = 266/512 (51%), Gaps = 43/512 (8%)
Query: 69 DFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTEC 128
DF L LD +L++GA++++F LSL +++ + W ++++ C+ GK EC
Sbjct: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSL-LQATEWASSEDTRRSCQSKGK-TEEEC 182
Query: 129 ANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQ 188
N++RVL + +++CGT AF P+C +G I +G +CP+DP+
Sbjct: 183 QNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTI-------EKINGVARCPYDPR 234
Query: 189 QPFASVMTDE-YLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTF 247
+V++ + LY+ T DF G+D A RSLG +RT WLN F+ +
Sbjct: 235 HNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPP---LRTAQYNSKWLNEPNFVAAY 291
Query: 248 FIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKAR 307
I YFF RE++ E +T+ SRV RVCKNDVGG+ L + WTTF+KAR
Sbjct: 292 DIGLF-------AYFFLRENAVEHDCG-RTVYSRVARVCKNDVGGRFLLEDTWTTFMKAR 343
Query: 308 LICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRA 367
L CS PG Y++ELQ + LP +D ++YGVFTT + SAVC ++++ I
Sbjct: 344 LNCSRPGE--VPFYYNELQSAFHLPEQD----LIYGVFTTNVNSIAASAVCAFNLSAISQ 397
Query: 368 VFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVM 427
FNGP+ ++E+ W+ IP + GT P + + + +R +M
Sbjct: 398 AFNGPFRYQENPRAAWLPIANPIPNFQCGTLPE------TGPNENLTERSLQDAQRLFLM 451
Query: 428 YKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVSISKEKW 487
++V PV P + +V R + +VVD V A+D Y V+++GT+ GT+LK +S +
Sbjct: 452 SEAVQPVTPEPCVTQDSV--RFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASR-- 507
Query: 488 NMEEVVLEELQIFK--HSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCC 545
++ LEEL + + ++ + + L++G RDG++++ L RC Y ++ C
Sbjct: 508 SLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAY-RSQGACL 566
Query: 546 LARDPYCAWDG--NACSRYAPTSKRRARRQDV 575
ARDPYC WDG CS +S Q++
Sbjct: 567 GARDPYCGWDGKQQRCSTLEDSSNMSLWTQNI 598
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 248 bits (632), Expect = 2e-65
Identities = 166/496 (33%), Positives = 255/496 (51%), Gaps = 44/496 (8%)
Query: 64 SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKD 123
+ +DF L D + L++GA++++F L L DL+ + + W + + C GK
Sbjct: 52 AKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGK- 109
Query: 124 ANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKC 183
+ EC N+IRVL ++ CGT AF P+C L E H+ SG +C
Sbjct: 110 SKEECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTE-------IHDQISGMARC 161
Query: 184 PFDPQQPFASVMT-DEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAK 242
P+ PQ +++T LY+ TA DF G+D A RSLG +RT WLN
Sbjct: 162 PYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPP---LRTAQYNSKWLNEPN 218
Query: 243 FIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTT 302
F+ ++ I + YFFFRE++ E KT+ SR RVCKND+GG+ L + WTT
Sbjct: 219 FVSSYDIGNF-------TYFFFRENAVEHDCG-KTVFSRAARVCKNDIGGRFLLEDTWTT 270
Query: 303 FLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSM 362
F+KARL CS PG Y++ELQ + LP D ++YG+FTT + SAVCV+++
Sbjct: 271 FMKARLNCSRPGE--VPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNL 324
Query: 363 ADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIK 422
+ I F+GP+ ++E++ W+ Y P+ + GT Y + T D FI
Sbjct: 325 SAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLY---VNLTERNLQDAQKFIL 381
Query: 423 RHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKV-VS 481
H V V PV P+F N R + + VD V + +++L TD GT+ KV V
Sbjct: 382 MHEV----VQPVTTVPSFMEDN--SRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVP 435
Query: 482 ISKEKWNMEEVVLEELQIF--KHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGK 539
+++ +LEE+++F + I ++++ Q L++G R+ +V++ L RC Y +
Sbjct: 436 LNQ---TSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFY-R 491
Query: 540 ACADCCLARDPYCAWD 555
+ C A+DPYC WD
Sbjct: 492 TRSTCIGAQDPYCGWD 507
>gi|19718780 semaphorin 6B precursor [Homo sapiens]
Length = 888
Score = 246 bits (627), Expect = 8e-65
Identities = 177/588 (30%), Positives = 287/588 (48%), Gaps = 63/588 (10%)
Query: 20 PALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEG----------LD 69
PAL++L +L G + P L + +D L N F+GS G L+
Sbjct: 11 PALLLL--LLLLGGAHGLFPEEPPPLSVAPRDYL--NHYPVFVGSGPGRLTPAEGADDLN 66
Query: 70 FQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKLAGKDAN 125
Q +L L +G +D+++ + L +K+ W + + +C++ GK
Sbjct: 67 IQRVL--RVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEG 124
Query: 126 TECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPF 185
EC NF++VL +++ ++VCG+ AF+P+C Y D + + + SG +CP+
Sbjct: 125 -ECRNFVKVLLLRDESTLFVCGSNAFNPVCAN-----YSIDTLQPVGDNI--SGMARCPY 176
Query: 186 DPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIG 245
DP+ ++ +D L++ T +DFL D RSLG D +RT + W F+
Sbjct: 177 DPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLG---DRPTLRTVKHDSKWFKEPYFVH 233
Query: 246 TFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQ-RSLINKWTTFL 304
+YFFFRE + E + +K ++SRV RVCKNDVGG R L +WT+FL
Sbjct: 234 AV-------EWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFL 286
Query: 305 KARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMAD 364
KARL CS+PG + YF+ LQ + + + R PVV VF+T S+ GSAVC + +
Sbjct: 287 KARLNCSVPGD--SHFYFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQ 343
Query: 365 IRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTC--PSKTYDPLIKSTRDFPDDVISFI 421
+ AVF G + ++S + W + ++P PRPG C P Y+ ++ PDD+++F+
Sbjct: 344 VAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYN----ASSALPDDILNFV 399
Query: 422 KRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVV- 480
K H +M ++V + P R + ++LT++ VD G V+FLG++ GTVLK +
Sbjct: 400 KTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLV 459
Query: 481 --SISKEKWNMEEVVLEELQIFKHSSI-----------ILNMELSLKQQQLYIGSRDGLV 527
+ S + V LEE + ++ +L++EL L +V
Sbjct: 460 RPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVV 519
Query: 528 QLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPTSKRRARRQDV 575
++ + RC Y +C ++DPYC W + + R A QDV
Sbjct: 520 RVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRAAFEQDV 567
>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
Length = 652
Score = 194 bits (492), Expect = 3e-49
Identities = 159/574 (27%), Positives = 264/574 (45%), Gaps = 63/574 (10%)
Query: 107 WPAAKERVELCKLA-GKDAN--TECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVY 163
W + +V L GK+A+ T+C N+I +L+ ++ + CGT A HP C + G
Sbjct: 88 WVGGRGKVYLFDFPEGKNASVRTDCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTV 146
Query: 164 KEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTAS-DFLGKDTAFTRSLGPT 222
L R PF P + + + +YS ++ GK F R G +
Sbjct: 147 VP----------LGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGES 196
Query: 223 HDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRV 282
+ + + +FI + DDKIY+FFRE + + + +SRV
Sbjct: 197 ELY-------TSDTVMQNPQFIKATIVHQD-QAYDDKIYYFFREDNPDKNPEAPLNVSRV 248
Query: 283 GRVCKNDVGGQRSL-INKWTTFLKARLICSIPGSDGADTYFDELQDIYLLP--TRDERNP 339
++C+ D GG+ SL ++KW TFLKA L+CS + F+ LQD++LLP + R+
Sbjct: 249 AQLCRGDQGGESSLSVSKWNTFLKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDT 305
Query: 340 VVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCP 399
VYGVF S+ + SAVCVYS+ DI VF Y +P PRPG C
Sbjct: 306 RVYGVF---SNPWNYSAVCVYSLGDIDKVFRTSSLKG---------YHSSLPNPRPGKC- 352
Query: 400 SKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIA 459
+ + P + RH + + V P+ T + Y ++ V + A
Sbjct: 353 -------LPDQQPIPTETFQVADRHPEVAQRVEPMGPLKT-PLFHSKYHYQKVAVHRMQA 404
Query: 460 EDGQ-YDVMFLGTDIGTVLKVVSISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQL 518
G+ + V++L TD GT+ KVV +++ + ++E +Q F+ ++ I M L ++++L
Sbjct: 405 SHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIME-IQPFRRAAAIQTMSLDAERRKL 463
Query: 519 YIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKYG 578
Y+ S+ + Q+ L C+ YG C C ++RDPYC WD C + S R+ Q +
Sbjct: 464 YVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRC--ISIYSSERSVLQSINPA 521
Query: 579 DPITQCWDIEDSISHETADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREELK 638
+P +C + + A + + + +L C +S+ AT W + + ++ E
Sbjct: 522 EPHKEC----PNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGH 577
Query: 639 PDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTF 672
I L I +L + G Y+C+AQE ++
Sbjct: 578 QSPNCI-----LFIENLTAQQYGHYFCEAQEGSY 606
>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
Length = 666
Score = 190 bits (482), Expect = 5e-48
Identities = 152/551 (27%), Positives = 253/551 (45%), Gaps = 60/551 (10%)
Query: 127 ECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFD 186
+C N+I +L+ ++ + CGT A HP C + G L R PF
Sbjct: 125 DCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVP----------LGEMRGYAPFS 173
Query: 187 PQQPFASVMTDEYLYSGTAS-DFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIG 245
P + + + +YS ++ GK F R G + + + + +FI
Sbjct: 174 PDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELY-------TSDTVMQNPQFIK 226
Query: 246 TFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSL-INKWTTFL 304
+ DDKIY+FFRE + + + +SRV ++C+ D GG+ SL ++KW TFL
Sbjct: 227 ATIVHQD-QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFL 285
Query: 305 KARLICSIPGSDGADTYFDELQDIYLLP--TRDERNPVVYGVFTTTSSIFKGSAVCVYSM 362
KA L+CS + F+ LQD++LLP + R+ VYGVF S+ + SAVCVYS+
Sbjct: 286 KAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVF---SNPWNYSAVCVYSL 339
Query: 363 ADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIK 422
DI VF Y +P PRPG C + + P +
Sbjct: 340 GDIDKVFRTSSLKG---------YHSSLPNPRPGKC--------LPDQQPIPTETFQVAD 382
Query: 423 RHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQ-YDVMFLGTDIGTVLKVVS 481
RH + + V P+ T + Y ++ V + A G+ + V++L TD GT+ KVV
Sbjct: 383 RHPEVAQRVEPMGPLKT-PLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE 441
Query: 482 ISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKAC 541
+++ + ++E +Q F+ ++ I M L ++++LY+ S+ + Q+ L C+ YG C
Sbjct: 442 PGEQEHSFAFNIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGC 500
Query: 542 ADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVI 601
C ++RDPYC WD C + S R+ Q + +P +C + + A + +
Sbjct: 501 HGCLMSRDPYCGWDQGRC--ISIYSSERSVLQSINPAEPHKEC----PNPKPDKAPLQKV 554
Query: 602 FGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSG 661
+ +L C +S+ AT W + + ++ E I L I +L + G
Sbjct: 555 SLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYG 609
Query: 662 MYYCKAQEHTF 672
Y+C+AQE ++
Sbjct: 610 HYFCEAQEGSY 620
>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
Length = 501
Score = 180 bits (457), Expect = 4e-45
Identities = 126/420 (30%), Positives = 207/420 (49%), Gaps = 40/420 (9%)
Query: 257 DDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSL-INKWTTFLKARLICSIPGS 315
DDKIY+FFRE + + + +SRV ++C+ D GG+ SL ++KW TFLKA L+CS
Sbjct: 72 DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCS---D 128
Query: 316 DGADTYFDELQDIYLLP--TRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPY 373
+ F+ LQD++LLP + R+ VYGVF S+ + SAVCVYS+ DI VF
Sbjct: 129 AATNKNFNRLQDVFLLPDPSGQWRDTRVYGVF---SNPWNYSAVCVYSLGDIDKVFRTSS 185
Query: 374 AHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYP 433
Y +P PRPG C + + P + RH + + V P
Sbjct: 186 LKG---------YHSSLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEP 228
Query: 434 VAGGPTFKRINVDYRLTQIVVDHVIAEDGQ-YDVMFLGTDIGTVLKVVSISKEKWNMEEV 492
+ T + Y ++ V + A G+ + V++L TD GT+ KVV +++ +
Sbjct: 229 MGPLKT-PLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFN 287
Query: 493 VLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYC 552
++E +Q F+ ++ I M L ++++LY+ S+ + Q+ L C+ YG C C ++RDPYC
Sbjct: 288 IME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYC 346
Query: 553 AWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFLE 612
WD C + S R+ Q + +P +C + + A + + + +L
Sbjct: 347 GWDQGRC--ISIYSSERSVLQSINPAEPHKEC----PNPKPDKAPLQKVSLAPNSRYYLS 400
Query: 613 CIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTF 672
C +S+ AT W + + ++ E I L I +L + G Y+C+AQE ++
Sbjct: 401 CPMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYGHYFCEAQEGSY 455
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,100,612
Number of Sequences: 37866
Number of extensions: 1379349
Number of successful extensions: 4273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 3883
Number of HSP's gapped (non-prelim): 226
length of query: 777
length of database: 18,247,518
effective HSP length: 110
effective length of query: 667
effective length of database: 14,082,258
effective search space: 9392866086
effective search space used: 9392866086
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.