Guide to the Human Genome
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Search of human proteins with 39777610

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39777610 semaphorin 4B precursor [Homo sapiens]
         (837 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39777610 semaphorin 4B precursor [Homo sapiens]                   1714   0.0  
gi|39777608 semaphorin 4B precursor [Homo sapiens]                   1714   0.0  
gi|157388902 semaphorin 4C [Homo sapiens]                             480   e-135
gi|21361914 semaphorin B [Homo sapiens]                               471   e-133
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]                   459   e-129
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]                   456   e-128
gi|28872814 semaphorin 4G [Homo sapiens]                              394   e-109
gi|19923279 semaphorin W [Homo sapiens]                               391   e-108
gi|5174673 semaphorin 3A precursor [Homo sapiens]                     324   2e-88
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]          314   2e-85
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]           314   2e-85
gi|41406086 semaphorin 3D [Homo sapiens]                              313   3e-85
gi|9910362 semaphorin sem2 [Homo sapiens]                             313   3e-85
gi|5454048 semaphorin 3C [Homo sapiens]                               311   1e-84
gi|188497703 semaphorin 3F [Homo sapiens]                             294   3e-79
gi|6912650 semaphorin 3E [Homo sapiens]                               290   4e-78
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]          265   2e-70
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]          263   7e-70
gi|19718780 semaphorin 6B precursor [Homo sapiens]                    263   7e-70
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]          261   2e-69
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]          260   4e-69
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]          258   1e-68
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]                    253   4e-67
gi|16306552 semaphorin Y [Homo sapiens]                               246   8e-65
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas...   243   4e-64
gi|147904700 semaphorin 5A [Homo sapiens]                             240   5e-63
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]       233   6e-61
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]     228   2e-59
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]          223   6e-58
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]                   210   4e-54

>gi|39777610 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score = 1714 bits (4438), Expect = 0.0
 Identities = 837/837 (100%), Positives = 837/837 (100%)

Query: 1   MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL 60
           MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL
Sbjct: 1   MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL 60

Query: 61  RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC 120
           RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC
Sbjct: 61  RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC 120

Query: 121 SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED 180
           SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED
Sbjct: 121 SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED 180

Query: 181 GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240
           GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF
Sbjct: 181 GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240

Query: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW 300
           VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW
Sbjct: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW 300

Query: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
           TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV
Sbjct: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360

Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
           FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL
Sbjct: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420

Query: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480
           NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG
Sbjct: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480

Query: 481 PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD 540
           PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD
Sbjct: 481 PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD 540

Query: 541 PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ 600
           PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ
Sbjct: 541 PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ 600

Query: 601 FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE 660
           FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE
Sbjct: 601 FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE 660

Query: 661 EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV 720
           EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV
Sbjct: 661 EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV 720

Query: 721 MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST 780
           MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST
Sbjct: 721 MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST 780

Query: 781 PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV 837
           PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV
Sbjct: 781 PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV 837


>gi|39777608 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score = 1714 bits (4438), Expect = 0.0
 Identities = 837/837 (100%), Positives = 837/837 (100%)

Query: 1   MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL 60
           MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL
Sbjct: 1   MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL 60

Query: 61  RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC 120
           RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC
Sbjct: 61  RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC 120

Query: 121 SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED 180
           SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED
Sbjct: 121 SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED 180

Query: 181 GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240
           GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF
Sbjct: 181 GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240

Query: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW 300
           VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW
Sbjct: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW 300

Query: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
           TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV
Sbjct: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360

Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
           FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL
Sbjct: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420

Query: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480
           NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG
Sbjct: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480

Query: 481 PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD 540
           PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD
Sbjct: 481 PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD 540

Query: 541 PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ 600
           PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ
Sbjct: 541 PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ 600

Query: 601 FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE 660
           FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE
Sbjct: 601 FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE 660

Query: 661 EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV 720
           EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV
Sbjct: 661 EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV 720

Query: 721 MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST 780
           MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST
Sbjct: 721 MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST 780

Query: 781 PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV 837
           PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV
Sbjct: 781 PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV 837


>gi|157388902 semaphorin 4C [Homo sapiens]
          Length = 833

 Score =  480 bits (1236), Expect = e-135
 Identities = 300/740 (40%), Positives = 401/740 (54%), Gaps = 63/740 (8%)

Query: 42  WALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLP 101
           W L PR ++  G       RF    I ++  L L+     LYVGAREALFA S     L 
Sbjct: 25  WNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQ 84

Query: 102 GGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYI 161
           G     + W A  EKK +C  KGK+ Q +C N+I+ L P + SHL+ CGT AF P CTY+
Sbjct: 85  GA----ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYV 140

Query: 162 NMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ 221
           NM  FTL   E      EDGKG+CP+DP      L+VDGELY+ T+++F G +P I R+ 
Sbjct: 141 NMLTFTLEHGE-----FEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNM 195

Query: 222 SLRPT-KTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVS 280
               + KTE    WL +P FV SAY+PES+GS  GDDDK+YFFF E   E + +   +V+
Sbjct: 196 GPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVA 255

Query: 281 RIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLF 340
           R+AR+CKGD GG R LQ++WT+FLKA+L CS P+    FN LQ + TL  +   W +T F
Sbjct: 256 RVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDT--SWHNTTF 313

Query: 341 YGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACI 400
           +GVF +QW  G    SA+C + ++++QRVF G YKE + E Q+W   T PVP+PRPG+CI
Sbjct: 314 FGVFQAQW--GDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCI 371

Query: 401 TNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---SRMLLLQPQARYQRVAVHRVPGL 457
            N  R     SSL+LPD +LNF+K H LM+ QV    SR LL++    +  +   RV GL
Sbjct: 372 NNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGL 431

Query: 458 H-HTYDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHS 516
              TY VLF+GTGDG L KAVS+GP VH+IEELQ+F   +P+++L+L   + LL+A S S
Sbjct: 432 DGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQ-EPMRSLVLSQSKKLLFAGSRS 490

Query: 517 GVVQVPMANCSLYRSCGDCLLARDPYCAWS--GSSCKHVSLYQPQLATRPWIQDIEGASA 574
            +VQ+P+A+C  YRSC DC+LARDPYCAWS   S C  V  +   L     IQ +  +  
Sbjct: 491 QLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLL----IQHVMTSDT 546

Query: 575 KDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASAS 634
             +C+     S    PT     + +     T   L C L SNLA   W   G  + A   
Sbjct: 547 SGICNLRG--SKKVRPTP----KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP 600

Query: 635 CHVLPTGDL-----LLVGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTDEGGSV 689
              L    L     +    +  G + C+S E+G +     Y   VV          G SV
Sbjct: 601 GSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVV---------AGPSV 651

Query: 690 PVIISTSRVSAPAGGKASWGADRSYWKEFLVMCTLFVL-AVLLPVLFLLYRHRNSMKVFL 748
                T    AP                 LV   +  L AV L +L L+   R  ++  L
Sbjct: 652 -----TLEARAPLENLG------------LVWLAVVALGAVCLVLLLLVLSLRRRLREEL 694

Query: 749 KQGECASVHPKTCPVVLPPE 768
           ++G  A+      P+ LP E
Sbjct: 695 EKGAKATERTLVYPLELPKE 714


>gi|21361914 semaphorin B [Homo sapiens]
          Length = 761

 Score =  471 bits (1213), Expect = e-133
 Identities = 297/760 (39%), Positives = 422/760 (55%), Gaps = 59/760 (7%)

Query: 18  ALPPRPPLLLLLLLLLLLQPPPPTWALS-------PRISLPLGSEERPFLRFEAEHISNY 70
           AL   P  LL L L  LLQ   PT           PR+    G E R    F  + + ++
Sbjct: 5   ALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDF 64

Query: 71  TALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRD 130
             LLLS DG TLYVGAREA+ AL      +P  +   + W A   KK +C+FK K  +  
Sbjct: 65  DTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNM-IPWPASDRKKSECAFKKKSNETQ 123

Query: 131 CQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPN 190
           C N+I++L+  + +HL+TCGT AFSP CT+I +++  L    +  V+  +GKG+ PFDP 
Sbjct: 124 CFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVM--EGKGQSPFDPA 181

Query: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTESSLNWLQ-DPAFVASAYIPE 248
            K TA++VDG LY+GT+++F G++P + R+   +P  KT++ L WL  D +FVA+  IP 
Sbjct: 182 HKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA--IPS 239

Query: 249 SLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQL 308
           +          +YFFF ET  EF+FFE    SR+AR+CK D GGE++LQ++WT+FLKAQL
Sbjct: 240 T--------QVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQL 291

Query: 309 LCSRPDDGFPFNVLQDVFTL---SPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365
           LC++P    PFNV++    L   SP+         Y VFTSQW  G T  SAVC F++ D
Sbjct: 292 LCTQPGQ-LPFNVIRHAVLLPADSPTAPH-----IYAVFTSQWQVGGTRSSAVCAFSLLD 345

Query: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425
           ++RVF G YKE+N+ET +W T   P   PRPG+C    +            D+ L F+KD
Sbjct: 346 IERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPS-----------SDKALTFMKD 394

Query: 426 HFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSVG-PRV 483
           HFLMD QV    LL++    Y R+AV    GL  H++ V++LGT  G LHKAV  G    
Sbjct: 395 HFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSA 454

Query: 484 HIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYC 543
           H++EE+Q+F   +PV+NL L   +G ++     GV +VP ANCS+Y SC DC+LARDP+C
Sbjct: 455 HLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHC 514

Query: 544 AWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGE-KPCEQVQFQ 602
           AW   S     L  P L    W QD+E  + +  C AS  +S S  P    +  ++V   
Sbjct: 515 AWDPESRTCCLLSAPNL--NSWKQDMERGNPEWAC-ASGPMSRSLRPQSRPQIIKEVLAV 571

Query: 603 PNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGE-FQCWSLEE 661
           PN++  L CP LS LA+  W    A V  ++S   +  G LLL+    +G  +QCW+ E 
Sbjct: 572 PNSILELPCPHLSALASYYWSHGPAAVPEASS--TVYNGSLLLIVQDGVGGLYQCWATEN 629

Query: 662 GFQQLVASYCPEVVEDGVADQTDEGGSVP---VIISTSRVSAPAGGKASWGADRSYWKEF 718
           GF   V SY  +  +  +A   +  G +P   V +  +RVS    G A+  A +SYW  F
Sbjct: 630 GFSYPVISYWVDSQDQTLALDPELAG-IPREHVKVPLTRVS----GGAALAAQQSYWPHF 684

Query: 719 LVMCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHP 758
           + +  LF L +   ++ L+     +++   K   C ++ P
Sbjct: 685 VTVTVLFALVLSGALIILVASPLRALRARGKVQGCETLRP 724


>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
          Length = 862

 Score =  459 bits (1182), Expect = e-129
 Identities = 278/669 (41%), Positives = 389/669 (58%), Gaps = 46/669 (6%)

Query: 24  PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLY 83
           P+  LL+ L ++      +A  PRI+      E   ++F    I NY+ALLLS D  TLY
Sbjct: 6   PIRGLLMALAVMFGTAMAFAPIPRITWE--HREVHLVQFHEPDIYNYSALLLSEDKDTLY 63

Query: 84  VGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLS 142
           +GAREA+FA+++ N+S     +  E+ W    +KK +C+ KGK  Q +C NYI++L PLS
Sbjct: 64  IGAREAVFAVNALNIS----EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119

Query: 143 GSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGEL 202
            + L+ CGT AF P C ++N+ +F            EDGKGRCPFDP    T+++VDGEL
Sbjct: 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKN------EDGKGRCPFDPAHSYTSVMVDGEL 173

Query: 203 YTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYF 262
           Y+GT  +F G++P ISR+ S  P +TE ++ WL +P+FV +  I +S  S  G+DD++YF
Sbjct: 174 YSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233

Query: 263 FFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVL 322
           FF+E   E+EF    ++ RIAR+CKGD+GG R LQ++WTSFLKA+L+CSRPD G  FNVL
Sbjct: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVL 293

Query: 323 QDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS-GLYKE---VN 378
           +DVF L  SP   +  +FY +FT Q +      SAVC + +   + VFS G Y +   V 
Sbjct: 294 RDVFVLR-SP-GLKVPVFYALFTPQLN--NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349

Query: 379 RETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---S 435
           +   +W     PVP PRPGACI + AR     SSL LPD+ L F+KDH LMD  V    +
Sbjct: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409

Query: 436 RMLLLQPQARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSS 494
           R  L++    Y ++ V R   L  T YDV+F+ T  G LHKA+S+   VHIIEE Q+F  
Sbjct: 410 RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQD 469

Query: 495 GQPVQNLLLDTHRG--LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKH 552
            +PVQ LLL + +G   +YA S+SGVVQ P+A C  + +C DC+LARDPYCAWS  +   
Sbjct: 470 FEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATC 529

Query: 553 VSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACP 612
           V+L+Q +  +R  IQ++ G ++  +C   S  S            Q  F+      L C 
Sbjct: 530 VALHQTESPSRGLIQEMSGDAS--VCPDKSKGS----------YRQHFFKHGGTAELKCS 577

Query: 613 LLSNLATRLW-LRNGAPVNASASCHVLPTGDLLLVGTQQ--LGEFQCWSLE----EGFQQ 665
             SNLA   W  +NG     S    ++   +LL+    +   G +QC S E    +   Q
Sbjct: 578 QKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQ 637

Query: 666 LVASYCPEV 674
           +VA +  EV
Sbjct: 638 VVAKHVLEV 646


>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
          Length = 738

 Score =  456 bits (1173), Expect = e-128
 Identities = 255/570 (44%), Positives = 355/570 (62%), Gaps = 29/570 (5%)

Query: 24  PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLY 83
           P+  LL+ L ++      +A  PRI+      E   ++F    I NY+ALLLS D  TLY
Sbjct: 6   PIRGLLMALAVMFGTAMAFAPIPRITWE--HREVHLVQFHEPDIYNYSALLLSEDKDTLY 63

Query: 84  VGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLS 142
           +GAREA+FA+++ N+S     +  E+ W    +KK +C+ KGK  Q +C NYI++L PLS
Sbjct: 64  IGAREAVFAVNALNIS----EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119

Query: 143 GSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGEL 202
            + L+ CGT AF P C ++N+ +F            EDGKGRCPFDP    T+++VDGEL
Sbjct: 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKN------EDGKGRCPFDPAHSYTSVMVDGEL 173

Query: 203 YTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYF 262
           Y+GT  +F G++P ISR+ S  P +TE ++ WL +P+FV +  I +S  S  G+DD++YF
Sbjct: 174 YSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233

Query: 263 FFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVL 322
           FF+E   E+EF    ++ RIAR+CKGD+GG R LQ++WTSFLKA+L+CSRPD G  FNVL
Sbjct: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVL 293

Query: 323 QDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS-GLYKE---VN 378
           +DVF L  SP   +  +FY +FT Q +      SAVC + +   + VFS G Y +   V 
Sbjct: 294 RDVFVLR-SP-GLKVPVFYALFTPQLN--NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349

Query: 379 RETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---S 435
           +   +W     PVP PRPGACI + AR     SSL LPD+ L F+KDH LMD  V    +
Sbjct: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409

Query: 436 RMLLLQPQARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSS 494
           R  L++    Y ++ V R   L  T YDV+F+ T  G LHKA+S+   VHIIEE Q+F  
Sbjct: 410 RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQD 469

Query: 495 GQPVQNLLLDTHRG--LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKH 552
            +PVQ LLL + +G   +YA S+SGVVQ P+A C  + +C DC+LARDPYCAWS  +   
Sbjct: 470 FEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATC 529

Query: 553 VSLYQPQLATRPWIQDIEGASAKDLCSASS 582
           V+L+Q +  +R  IQ++ G ++  +C ASS
Sbjct: 530 VALHQTESPSRGLIQEMSGDAS--VCPASS 557


>gi|28872814 semaphorin 4G [Homo sapiens]
          Length = 843

 Score =  394 bits (1013), Expect = e-109
 Identities = 262/681 (38%), Positives = 363/681 (53%), Gaps = 57/681 (8%)

Query: 16  WGALPPRPPLLLLLLLLLLLQPPP----PTWAL--SPRISLPLGSEERPFLRFEAEHISN 69
           WG L P    LLL +L     P P    P+  L  +PR+++P   EE    R       N
Sbjct: 2   WGRLWP----LLLSILTATAVPGPSLRRPSRELDATPRMTIPY--EELSGTRHFKGQAQN 55

Query: 70  YTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQR 129
           Y+ LLL      L VGAR ALF+LS+N   +  G ++E+ W A  E + +C  KGK+ Q 
Sbjct: 56  YSTLLLEEASARLLVGARGALFSLSAN--DIGDGAHKEIHWEASPEMQSKCHQKGKNNQT 113

Query: 130 DCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDP 189
           +C N+++ L  L+ +HL+ CGT AF P+C  I+ E FTL          E+GK +CP+DP
Sbjct: 114 ECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAFTLPTS------FEEGKEKCPYDP 167

Query: 190 NFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESS-LNWLQDPAFVASAYIPE 248
               T L++DG LYT T   F+ + P I RS+     +TE + ++WL D  FV S  + E
Sbjct: 168 ARGFTGLIIDGGLYTATRYEFR-SIPDIRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRE 226

Query: 249 SLGSLQGDDDKIYFFFSE------TGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTS 302
           S  S  GDDDK+Y+FF+E      +G   +   +  V+R+AR+CKGD GG+++LQ++WTS
Sbjct: 227 SKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTS 286

Query: 303 FLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFT 362
           FLKA+L+C  P     +  L+ V +L         T FY  FT      T E SA+C + 
Sbjct: 287 FLKARLICHIP----LYETLRGVCSLDAETSS--RTHFYAAFTLSTQWKTLEASAICRYD 340

Query: 363 MKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNF 422
           + ++Q VF+G Y E    +++W      VP PRPG+CIT+S R +  NSS  LP  VL+F
Sbjct: 341 LAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDF 400

Query: 423 LKDHFLMDGQV---RSRMLLLQPQARYQRVAVHRVPG-LHHTYDVLFLGTGDGRLHKAVS 478
           +K H LM   V   R R LLL+   RY  +    V      TYD+LFLGT DG +HKAV 
Sbjct: 401 VKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVV 460

Query: 479 VGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLA 538
           +G  +HIIEE Q+F   Q V+NL++   +  LY  + SGV+Q+P+++CS YRSC DC+LA
Sbjct: 461 LGSGMHIIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSCSRYRSCYDCILA 520

Query: 539 RDPYCAWSGSSCKHVSLYQPQLATR------PWIQDIEGASAKDLCSASSVVSPSFVPTG 592
           RDPYC W   +  H       +A R        IQDIE  +    C +S    P      
Sbjct: 521 RDPYCGWDPGT--HACAAATTIANRSQGSRTALIQDIERGNRG--CESSRDTGP------ 570

Query: 593 EKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQ-- 650
             P +           L C   SNLA  LWL NG+   +          D LLV   Q  
Sbjct: 571 PPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNGSMGLSDGQGGYRVGVDGLLVTDAQPE 630

Query: 651 -LGEFQCWSLEEGFQQLVASY 670
             G + C++ E G + L+ASY
Sbjct: 631 HSGNYGCYAEENGLRTLLASY 651


>gi|19923279 semaphorin W [Homo sapiens]
          Length = 770

 Score =  391 bits (1004), Expect = e-108
 Identities = 254/670 (37%), Positives = 348/670 (51%), Gaps = 51/670 (7%)

Query: 15  PWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALL 74
           P    P   P  LLLL +L            PR SLP+   +    RF   H  NY+ LL
Sbjct: 10  PGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLL 69

Query: 75  LSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNY 134
           +     TLYVGAR+ +FALS   S   G   + + W      +Q C  KGK  + +C N+
Sbjct: 70  VDPASHTLYVGARDTIFALSLPFS---GERPRRIDWMVPEAHRQNCRKKGKK-EDECHNF 125

Query: 135 IKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKST 194
           ++IL   + SHL TCGT AF P C  I++  F           LE G+G+CPF+P  +S 
Sbjct: 126 VQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVER------LESGRGKCPFEPAQRSA 179

Query: 195 ALVVDGELYTGTVSSFQGNDPAISRSQSLRPT--KTESSLNWLQDPAFVAS-AYIPESLG 251
           A++  G LY  TV ++ G +P I+R+        +T++  +WL  PAFVA+ A  P   G
Sbjct: 180 AVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWG 239

Query: 252 SLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCS 311
              GDD+ IYFFF+ET + F+ +E   V R+AR+C GD GG + LQQRWT+FLKA LLC 
Sbjct: 240 DEDGDDE-IYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCP 298

Query: 312 RPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS 371
            P+ G   +VLQDV  L P        +FYG+F+SQW   T   SAVC F  +D++ V +
Sbjct: 299 GPEHGRASSVLQDVAVLRPE-LGAGTPIFYGIFSSQWEGATI--SAVCAFRPQDIRTVLN 355

Query: 372 GLYKEVNRETQQWY-TVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMD 430
           G ++E+  +  +    V + VP PRPG CITN+ + R   SSL LPDRVL F++DH LMD
Sbjct: 356 GPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMD 415

Query: 431 GQV---RSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSVGPRVHII 486
             V       LL+     Y RV  HRV  L    YDVL+LGT DG LH+AV +G ++ ++
Sbjct: 416 RPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVL 475

Query: 487 EELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWS 546
           E+L +F   QPV+N+ L  +   L   S + V QV   NC   +SC +C+LA+DP CAWS
Sbjct: 476 EDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWS 533

Query: 547 ---GSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCE-QVQFQ 602
                   H   +      R  +QDIE A    LC             GE+P   +V   
Sbjct: 534 FRLDECVAHAGEH------RGLVQDIESADVSSLCPKE---------PGERPVVFEVPVA 578

Query: 603 PNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLL--LVGTQQLGEFQCWSLE 660
                 L C   S  A+ +W +   P   +A   + P  D L  +V    +G + C   E
Sbjct: 579 TAAHVVLPCSPSSAWASCVWHQ---PSGVTA---LTPRRDGLEVVVTPGAMGAYACECQE 632

Query: 661 EGFQQLVASY 670
            G   +VA+Y
Sbjct: 633 GGAAHVVAAY 642


>gi|5174673 semaphorin 3A precursor [Homo sapiens]
          Length = 771

 Score =  324 bits (831), Expect = 2e-88
 Identities = 215/636 (33%), Positives = 324/636 (50%), Gaps = 48/636 (7%)

Query: 68  SNYTALLLSRDGRTLYVGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKD 126
           S+Y   LL  +   LYVGA++ +F+    N+      ++Q+++W     ++ +C + GKD
Sbjct: 55  SSYHTFLLDEERSRLYVGAKDHIFSFDLVNIK-----DFQKIVWPVSYTRRDECKWAGKD 109

Query: 127 PQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEK-GNVLLEDGKGRC 185
             ++C N+IK+L   + +HL+ CGT AF P+CTYI + +       K  N   E+G+G+ 
Sbjct: 110 ILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKS 169

Query: 186 PFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQS-LRPTKTES-SLNWLQDPAFVAS 243
           P+DP   + +L++DGELY+GT + F G D AI R+     P +TE     WL DP F+++
Sbjct: 170 PYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISA 229

Query: 244 AYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSF 303
             I ES      +DDK+YFFF E   + E       +RI +ICK D GG R L  +WT+F
Sbjct: 230 HLISESDNP---EDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTF 286

Query: 304 LKAQLLCSRPDDG---FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
           LKA+L+CS P        F+ LQDVF +  + +D ++ + YGVFT+       +GSAVC+
Sbjct: 287 LKARLICSVPGPNGIDTHFDELQDVFLM--NFKDPKNPVVYGVFTTS--SNIFKGSAVCM 342

Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
           ++M DV+RVF G Y   +    QW      VP PRPG C   S      +S+  LPD V+
Sbjct: 343 YSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTC--PSKTFGGFDSTKDLPDDVI 400

Query: 421 NFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLHK 475
            F + H  M   V    +R ++++    YQ  ++ V RV      YDV+F+GT  G + K
Sbjct: 401 TFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLK 460

Query: 476 AVSVGPRVH------IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY 529
            VS+           ++EE+ +F     +  + L T +  LY  S +GV Q+P+  C +Y
Sbjct: 461 VVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIY 520

Query: 530 -RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSF 588
            ++C +C LARDPYCAW GS+C   S Y P    R   QDI        CS     +   
Sbjct: 521 GKACAECCLARDPYCAWDGSAC---SRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHH- 576

Query: 589 VPTGEKPCEQVQF-QPNTVNTLACPLLSNLATRLW----LRNGAPVNASASCHVLPTGDL 643
              G  P E++ +   N+   L C   S  A   W                 H++ T   
Sbjct: 577 ---GHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQG 633

Query: 644 LLVGTQQ---LGEFQCWSLEEGFQQLVASYCPEVVE 676
           LL+ + Q    G + C ++E GF Q +     EV++
Sbjct: 634 LLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVID 669


>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
          Length = 748

 Score =  314 bits (804), Expect = 2e-85
 Identities = 215/589 (36%), Positives = 303/589 (51%), Gaps = 47/589 (7%)

Query: 17  GALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEE--RPFLRFEAEHISNYTALL 74
           GA    P L LL  + L    P P     PR+ L     +       F  E    Y ALL
Sbjct: 5   GAAAVIPGLALLWAVGLGSAAPSP-----PRLRLSFQELQAWHGLQTFSLERTCCYQALL 59

Query: 75  LSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQN 133
           +  +   L+VGA   + +L+  N+S       ++L W A  E +++C++ GKD   +C N
Sbjct: 60  VDEERGRLFVGAENHVASLNLDNIS----KRAKKLAWPAPVEWREECNWAGKDIGTECMN 115

Query: 134 YIKILLPLSGSHLFTCGTAAFSPMCTYINMENFT---LARDEKGNVLLEDGKGRCPFDPN 190
           ++K+L   + +HL  CGT AF P C ++ + +     + R + G +  EDGKG+ P+DP 
Sbjct: 116 FVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRI--EDGKGKSPYDPR 173

Query: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTE-SSLNWLQDPAFVASAYIPE 248
            ++ +++V  ELY+G  +   G D  I RS   RP+ +TE     WL +P FV   +IPE
Sbjct: 174 HRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPE 233

Query: 249 SLGSLQGDDDKIYFFFSETGQE-FEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQ 307
           S      DDDKIYFFF ET  E         VSR+ +IC+ D GG+R L  +WT+FLKA+
Sbjct: 234 SENP---DDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKAR 290

Query: 308 LLCSRP--DDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365
           L+CS P  +    F+ LQDVF L  S +D R  L Y VF++       +GSAVCV++M D
Sbjct: 291 LVCSVPGVEGDTHFDQLQDVFLL--SSRDHRTPLLYAVFSTS---SIFQGSAVCVYSMND 345

Query: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425
           V+R F G +        QW +    VP PRPG C   S      +S+   PD V+ F ++
Sbjct: 346 VRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARN 403

Query: 426 HFLMDGQV---RSRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSV- 479
           H LM   V     R L LQ  A Y   ++A  RV      YDVLF+GT  G + K +SV 
Sbjct: 404 HPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVP 463

Query: 480 -GPRVH----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCG 533
            G R      ++EEL +F     V ++ + + R  LY AS S V Q+ +  C+ + R C 
Sbjct: 464 KGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCT 523

Query: 534 DCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASS 582
           +C LARDPYCAW G +C   + +QP    R   QD+       LCS  S
Sbjct: 524 ECCLARDPYCAWDGVAC---TRFQPSAKRRFRRQDVRNGDPSTLCSGDS 569


>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
          Length = 749

 Score =  314 bits (804), Expect = 2e-85
 Identities = 215/589 (36%), Positives = 303/589 (51%), Gaps = 46/589 (7%)

Query: 17  GALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEE--RPFLRFEAEHISNYTALL 74
           GA    P L LL  + L    P P     PR+ L     +       F  E    Y ALL
Sbjct: 5   GAAAVIPGLALLWAVGLGSAAPSP-----PRLRLSFQELQAWHGLQTFSLERTCCYQALL 59

Query: 75  LSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQN 133
           +  +   L+VGA   + +L+  N+S       ++L W A  E +++C++ GKD   +C N
Sbjct: 60  VDEERGRLFVGAENHVASLNLDNIS----KRAKKLAWPAPVEWREECNWAGKDIGTECMN 115

Query: 134 YIKILLPLSGSHLFTCGTAAFSPMCTYINMENFT---LARDEKGNVLLEDGKGRCPFDPN 190
           ++K+L   + +HL  CGT AF P C ++ + +     + R + G +  EDGKG+ P+DP 
Sbjct: 116 FVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRI--EDGKGKSPYDPR 173

Query: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTE-SSLNWLQDPAFVASAYIPE 248
            ++ +++V  ELY+G  +   G D  I RS   RP+ +TE     WL +P FV   +IPE
Sbjct: 174 HRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPE 233

Query: 249 SLGSLQGDDDKIYFFFSETGQE-FEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQ 307
           S      DDDKIYFFF ET  E         VSR+ +IC+ D GG+R L  +WT+FLKA+
Sbjct: 234 SENP---DDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKAR 290

Query: 308 LLCSRP--DDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365
           L+CS P  +    F+ LQDVF L  S +D R  L Y VF++       +GSAVCV++M D
Sbjct: 291 LVCSVPGVEGDTHFDQLQDVFLL--SSRDHRTPLLYAVFSTS--SSIFQGSAVCVYSMND 346

Query: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425
           V+R F G +        QW +    VP PRPG C   S      +S+   PD V+ F ++
Sbjct: 347 VRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARN 404

Query: 426 HFLMDGQV---RSRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSV- 479
           H LM   V     R L LQ  A Y   ++A  RV      YDVLF+GT  G + K +SV 
Sbjct: 405 HPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVP 464

Query: 480 -GPRVH----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCG 533
            G R      ++EEL +F     V ++ + + R  LY AS S V Q+ +  C+ + R C 
Sbjct: 465 KGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCT 524

Query: 534 DCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASS 582
           +C LARDPYCAW G +C   + +QP    R   QD+       LCS  S
Sbjct: 525 ECCLARDPYCAWDGVAC---TRFQPSAKRRFRRQDVRNGDPSTLCSGDS 570


>gi|41406086 semaphorin 3D [Homo sapiens]
          Length = 777

 Score =  313 bits (803), Expect = 3e-85
 Identities = 238/717 (33%), Positives = 353/717 (49%), Gaps = 67/717 (9%)

Query: 24  PLLLLLLLLLLLQPPPPTWALS-PRISLP-----LGSEERPFLRFEAEHISNYTALLLSR 77
           P L++L + +L  P   T   + PR+ L      L +   PFL   +E +   T LL   
Sbjct: 20  PALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLG-SSEGLDFQTLLLDEE 78

Query: 78  DGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKI 137
            GR L +GA++ +F LS  L  L    ++++ W A  E+ + C   GKD   +C N+I++
Sbjct: 79  RGRLL-LGAKDHIFLLS--LVDL-NKNFKKIYWPAAKERVELCKLAGKDANTECANFIRV 134

Query: 138 LLPLSGSHLFTCGTAAFSPMCTYINM----ENFTLARDEKGNVLLEDGKGRCPFDPNFKS 193
           L P + +H++ CGT AF P+C YI++    E+     D      LE G+ +CPFDP    
Sbjct: 135 LQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHN---LESGRLKCPFDPQQPF 191

Query: 194 TALVVDGELYTGTVSSFQGNDPAISRSQSLRPT------KTESSLN-WLQDPAFVASAYI 246
            +++ D  LY+GT S F G D A +RS  L PT      +T+ S + WL    F+ + +I
Sbjct: 192 ASVMTDEYLYSGTASDFLGKDTAFTRS--LGPTHDHHYIRTDISEHYWLNGAKFIGTFFI 249

Query: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKA 306
           P++      DDDKIYFFF E+ QE    + TI+SR+ R+CK D GG+R L  +WT+FLKA
Sbjct: 250 PDTYNP---DDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKA 306

Query: 307 QLLCSRP-DDGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
           +L+CS P  DG    F+ LQD++ L    +D R+ + YGVFT+       +GSAVCV++M
Sbjct: 307 RLICSIPGSDGADTYFDELQDIYLL--PTRDERNPVVYGVFTTT--SSIFKGSAVCVYSM 362

Query: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
            D++ VF+G Y        +W      +P PRPG C  +   +  I S+   PD V++F+
Sbjct: 363 ADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTC-PSKTYDPLIKSTRDFPDDVISFI 421

Query: 424 KDHFLMDGQV-----RSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS 478
           K H +M   V           +    R  ++ V  V      YDV+FLGT  G + K VS
Sbjct: 422 KRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVS 481

Query: 479 VGPRVH-----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSC 532
           +          ++EELQIF     + N+ L   +  LY  S  G+VQ+ +  C  Y ++C
Sbjct: 482 ISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKAC 541

Query: 533 GDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTG 592
            DC LARDPYCAW G++C   S Y P    R   QD++       C      S S     
Sbjct: 542 ADCCLARDPYCAWDGNAC---SRYAPTSKRRARRQDVKYGDPITQC-WDIEDSISHETAD 597

Query: 593 EKPCEQVQFQPNTVNTLACPLLSNLATRLWL--RNGAP--VNASASCHVLPTGDLLLVGT 648
           EK    ++F       L C   S  AT  W   R+G            ++ T   LL+ +
Sbjct: 598 EKVIFGIEFNS---TFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRS 654

Query: 649 QQ---LGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTD----EGGSVPVIISTSRV 698
            Q    G + C + E  F   +      V+E+   + T     E G V  +++ SR+
Sbjct: 655 LQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEHEEGKVKDLLAESRL 711


>gi|9910362 semaphorin sem2 [Homo sapiens]
          Length = 782

 Score =  313 bits (803), Expect = 3e-85
 Identities = 222/645 (34%), Positives = 320/645 (49%), Gaps = 50/645 (7%)

Query: 69  NYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQ 128
           N  A+ L      L++G  +AL++L  + ++    + +E+LW     ++++C  KG+DP 
Sbjct: 57  NLQAMYLDEYRDRLFLGGLDALYSLRLDQAW---PDPREVLWPPQPGQREECVRKGRDPL 113

Query: 129 RDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINM--ENFTLARDEKGNVLLEDGKGRCP 186
            +C N++++L P + +HL  CGT AF P C  I +      +   E G+V  E G+GRCP
Sbjct: 114 TECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSV--ESGRGRCP 171

Query: 187 FDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTESSLNWLQDPAFVASAY 245
            +P+    +  +DGELYTG  + F G +  I RS   RP  +++S  + L DP FV +A 
Sbjct: 172 HEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAAR 231

Query: 246 IPESLGSLQGDDDKIYFFFSETGQEFEFFENTI-VSRIARICKGDEGGERVLQQRWTSFL 304
           IPE+      D+DK+YFFFSET    +   N + VSR+ R+C  D GG+RVL  +W++FL
Sbjct: 232 IPENSDQ---DNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFL 288

Query: 305 KAQLLCSRPDDG---FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVF 361
           KA+L+CS P  G     F+ L+DVF L   P+  +    Y +F++       +G AVCV+
Sbjct: 289 KARLVCSVPGPGGAETHFDQLEDVFLL--WPKAGKSLEVYALFSTV--SAVFQGFAVCVY 344

Query: 362 TMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARE--RKINSSLQLPDRV 419
            M D+  VF+G +   +    QW      VP PRPG C +    +  R   S+   PD V
Sbjct: 345 HMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEV 404

Query: 420 LNFLKDHFLMDGQVR---SRMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLH 474
           L F + H LM   VR    R +L++     Q  ++ V RV     TYDV+FLGT  G + 
Sbjct: 405 LQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVL 464

Query: 475 KAV------SVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSL 528
           K +      S  P   ++EELQ+F    P+  + +   R +LY  S  GV Q+ +  C  
Sbjct: 465 KVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCET 524

Query: 529 Y-RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPW-IQDIEGASAKDLCSASSVVSP 586
           Y  +C +C LARDPYCAW G+SC H   Y+P L  R +  QDI   +    C   S    
Sbjct: 525 YGTACAECCLARDPYCAWDGASCTH---YRPSLGKRRFRRQDIRHGNPALQCLGQSQEEE 581

Query: 587 SFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWL--RNG--APVNASASCHVLPTGD 642
           +    G      V    +    L C   S  A   WL  R G   P        VL T  
Sbjct: 582 A---VGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTER 638

Query: 643 LLL---VGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTD 684
            LL   +     G + C +LE GF Q V      V+   VA Q D
Sbjct: 639 GLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVI---VASQLD 680


>gi|5454048 semaphorin 3C [Homo sapiens]
          Length = 751

 Score =  311 bits (798), Expect = 1e-84
 Identities = 215/656 (32%), Positives = 328/656 (50%), Gaps = 64/656 (9%)

Query: 64  AEHISNYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSF 122
           + H  +Y  LL+  D   +YVG+++ + +L+ +N+S     E   + W A   K ++C  
Sbjct: 48  SHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNIS----QEALSVFWPASTIKVEECKM 103

Query: 123 KGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYIN----MENFTLARDEKGNVLL 178
            GKDP   C N+++++   + +HL+ CG+ AFSP+CTY+N     E+     D K     
Sbjct: 104 AGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSK----C 159

Query: 179 EDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN--WLQ 236
           E GKGRC F+PN  + +++++ EL++G    F G D AI RS + R        N  WL 
Sbjct: 160 ESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLS 219

Query: 237 DPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVL 296
           +P FV +  IP+       +D K+YFFF E   +       I S IARIC  D GG R L
Sbjct: 220 EPMFVDAHVIPD---GTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSL 276

Query: 297 QQRWTSFLKAQLLCSRPDDGFP---FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTT 353
             +WT+FLKA+L+CS  D+  P   F+ L+DVF L     + R TL YG+FT+       
Sbjct: 277 VNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLL--ETDNPRTTLVYGIFTTS--SSVF 332

Query: 354 EGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSL 413
           +GSAVCV+ + D+Q VF+G +        Q  +    +P PRPG C    A    + ++ 
Sbjct: 333 KGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTC-PGGAFTPNMRTTK 391

Query: 414 QLPDRVLNFLKDHFLMDGQV-----RSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGT 468
           + PD V+ F+++H LM   +     R  ++ +    +Y ++AV RV      Y VLFLGT
Sbjct: 392 EFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGT 451

Query: 469 GDGRLHKAV------SVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVP 522
             G + K V      SV   + I+EEL++F +  P+  + + + +  LY +S+ GV QV 
Sbjct: 452 DRGTVQKVVVLPTNNSVSGEL-ILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVS 510

Query: 523 MANCSLY-RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSAS 581
           +  C +Y  +C DC LARDPYCAW G SC   S + P    R   QD+   +    C   
Sbjct: 511 LHRCHIYGTACADCCLARDPYCAWDGHSC---SRFYPTGKRRSRRQDVRHGNPLTQCRGF 567

Query: 582 SVVSPSFVPTGEKPCEQVQF-QPNTVNTLACPLLSNLATRLWL-------RNGAPVNASA 633
           +      +       E VQ+   N    L C   S  A+  WL       R    +N   
Sbjct: 568 N------LKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQKDKDRRKEVKLNE-- 619

Query: 634 SCHVLPTGDLLLVGTQQ---LGEFQCWSLEEGFQQLVASYCPEVVE-DGVADQTDE 685
              ++ T   LL+ + Q    G + C + E  F+Q +A    +V++ + VA  TD+
Sbjct: 620 --RIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDK 673


>gi|188497703 semaphorin 3F [Homo sapiens]
          Length = 785

 Score =  294 bits (752), Expect = 3e-79
 Identities = 209/657 (31%), Positives = 315/657 (47%), Gaps = 79/657 (12%)

Query: 68  SNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDP 127
           ++Y  LL   D   +YVG+++  + LS +L  +   E   + W A  ++ ++C   GKD 
Sbjct: 55  TDYRILLKDEDHDRMYVGSKD--YVLSLDLHDI-NREPLIIHWAASPQRIEECVLSGKDV 111

Query: 128 QRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMEN------FTLARDEKGN------ 175
             +C N+++++ P + +HL+ CGT A++PMCTY+N         +T  +  +G       
Sbjct: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171

Query: 176 --------------------VLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDP 215
                                 LE GKG+CP+DP   + + +++ ELY G    F G D 
Sbjct: 172 GALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDA 231

Query: 216 AISRSQSLRPTKTESSLN--WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEF 273
           AI R+   +        N  WL DP+F+ +  IP+   S + +DDK+YFFF E   E   
Sbjct: 232 AIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPD---SAERNDDKLYFFFRERSAEAP- 287

Query: 274 FENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRP-DDGFP--FNVLQDVFTLSP 330
               + +RI RIC  D+GG   L  +W++FLKA+L+CS P +DG    F+ LQDVF    
Sbjct: 288 QSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFV--Q 345

Query: 331 SPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHP 390
             QD R+ + Y VFTS        GSAVCV++M D++ VF+G +        QW   +  
Sbjct: 346 QTQDVRNPVIYAVFTSS--GSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGK 403

Query: 391 VPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ 447
           +P PRPG C         + S+   PD V+NF++ H LM   V   + R L+++  A Y+
Sbjct: 404 MPYPRPGTC-PGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYR 462

Query: 448 --RVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVGPRVH------IIEELQIFSSGQPVQ 499
              +AV +V      Y+VLFLGT  G + K + V P+        ++EE+++F    PV+
Sbjct: 463 LTTIAVDQVDAADGRYEVLFLGTDRGTVQKVI-VLPKDDQELEELMLEEVEVFKDPAPVK 521

Query: 500 NLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCGDCLLARDPYCAWSGSSCKHVSLYQP 558
            + + + R  LY AS  GV  + +  C  Y  +C DC LARDPYCAW G +C   S Y  
Sbjct: 522 TMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQAC---SRYTA 578

Query: 559 QLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQF-QPNTVNTLACPLLSNL 617
               R   QD+   +    C   +          +   E VQ+    +   L C   S  
Sbjct: 579 SSKRRSRRQDVRHGNPIRQCRGFN------SNANKNAVESVQYGVAGSAAFLECQPRSPQ 632

Query: 618 ATRLWLRNGAPVN----ASASCHVLPTGDLLLVGTQQL---GEFQCWSLEEGFQQLV 667
           AT  WL    P +      A    L T   LL+   QL   G + C + E  F+ +V
Sbjct: 633 ATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVV 689


>gi|6912650 semaphorin 3E [Homo sapiens]
          Length = 775

 Score =  290 bits (742), Expect = 4e-78
 Identities = 212/676 (31%), Positives = 327/676 (48%), Gaps = 51/676 (7%)

Query: 73  LLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQ 132
           +LL      L+VG R+ +++LS  L  +  G Y+E+ W + A K ++C  KGKD   +C 
Sbjct: 61  MLLDEYQERLFVGGRDLVYSLS--LERISDG-YKEIHWPSTALKMEECIMKGKDAG-ECA 116

Query: 133 NYIKILLPLSGSHLFTCGTAAFSPMCTYI----NMENFTLARDEKGNVLLEDGKGRCPFD 188
           NY+++L   + +HL TCGT AF P+C +I    ++E+     +   +   E G+GRCPFD
Sbjct: 117 NYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRS---ERGRGRCPFD 173

Query: 189 PNFKSTALVVDGELYTGTVSSFQGNDPAISRSQS-LRPTKTE-SSLNWLQDPAFVASAYI 246
           P+    + ++  EL+ G  S +   D AI RS   L   +TE      L++P FV S  I
Sbjct: 174 PSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMI 233

Query: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKA 306
           P++      DD+K+YFFF+E   E E   + I +R+ R+C  D GG+R+L  +W++FLKA
Sbjct: 234 PDNEDR---DDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKA 290

Query: 307 QLLCSRPD-DGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
           +L+CS P  +G    F+ L+DVF L    +D ++ + +G+F +        G A+CV+ M
Sbjct: 291 RLVCSVPGMNGIDTYFDELEDVFLL--PTRDHKNPVIFGLFNTT--SNIFRGHAICVYHM 346

Query: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
             ++  F+G Y         W      VP PRPG+C  +     +  ++   PD  + F 
Sbjct: 347 SSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSC-ASKVNGGRYGTTKDYPDDAIRFA 405

Query: 424 KDHFLMDGQVR---SRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS 478
           + H LM   ++    + +L++   +Y  +++AV RV      YDVLF+GT +G + K ++
Sbjct: 406 RSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVIT 465

Query: 479 V------GPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRS- 531
           +           I+EELQIF    P+ ++ + + R  LY  S S V QV   +C +Y S 
Sbjct: 466 IYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSA 525

Query: 532 CGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPT 591
           C DC LARDPYCAW G SC            R   QD+   +A   C     V  +   T
Sbjct: 526 CADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKT 585

Query: 592 GEKPCEQVQFQPNTVNTLACPLLSNLATRLWL------RNGAPVNASASCHVLPTGDLLL 645
            E     ++   N    L C   S  A  +W            V        +  G L L
Sbjct: 586 EEHLAYGIE---NNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFL 642

Query: 646 -VGTQQLGEFQCWSLEEGFQQLVASYCPEVV-EDGVADQTDEGGSVPVIISTSRVSAPAG 703
            +     G + C ++E  F   V     EVV E+ V D  ++           R+  PA 
Sbjct: 643 RLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEED---RHHRMPCPAQ 699

Query: 704 GKASWGADRSYWKEFL 719
              S GA + ++KEFL
Sbjct: 700 SSISQGA-KPWYKEFL 714


>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
          Length = 1073

 Score =  265 bits (676), Expect = 2e-70
 Identities = 187/586 (31%), Positives = 292/586 (49%), Gaps = 74/586 (12%)

Query: 63  EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
           E++H  ++  +L  RD  TLY+  R+ ++ +  NL+ +P  E    ++L W +  + ++ 
Sbjct: 52  ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107

Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
           C+ KGK    +C N+IK+ +P +   +F CGT AF+PMC Y  +       +E       
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161

Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
            G  RCPFD    + AL  DG+LY+ TV+ F  +D  I RS     +LR  K +S   W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218

Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
           ++P F+ +              + +YFFF E   E       + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268

Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
           VL++ WTSFLKA+L CS P D F  F+VLQ   D+  ++  P         GVFT+Q + 
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321

Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
            +  GSAVC F+M D+++VF G +KE       W  V    VP PRPG C  +   E   
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379

Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
            +S+  PD  L+F+K H LMD  V          + + RY+   ++V    G +  Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439

Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
           F+G+  G + K +      S+   V ++EE++ ++           + V +L LD     
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498

Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVSLYQPQLATRPWIQ 567
           LY A  S ++++P++ C  Y SC   C+ +RDPYC W S  SC  V+   P +    + Q
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT---PGMLAEGYEQ 555

Query: 568 DIEGASAKDLCSASSVVSPSFVPTGE---KPCEQVQFQPNTVNTLA 610
           D E  +   L     ++  S  P  +    P   ++   ++V T+A
Sbjct: 556 DTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMA 601


>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
          Length = 1017

 Score =  263 bits (671), Expect = 7e-70
 Identities = 183/563 (32%), Positives = 282/563 (50%), Gaps = 71/563 (12%)

Query: 63  EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
           E++H  ++  +L  RD  TLY+  R+ ++ +  NL+ +P  E    ++L W +  + ++ 
Sbjct: 52  ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107

Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
           C+ KGK    +C N+IK+ +P +   +F CGT AF+PMC Y  +       +E       
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161

Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
            G  RCPFD    + AL  DG+LY+ TV+ F  +D  I RS     +LR  K +S   W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218

Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
           ++P F+ +              + +YFFF E   E       + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268

Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
           VL++ WTSFLKA+L CS P D F  F+VLQ   D+  ++  P         GVFT+Q + 
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321

Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
            +  GSAVC F+M D+++VF G +KE       W  V    VP PRPG C  +   E   
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379

Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
            +S+  PD  L+F+K H LMD  V          + + RY+   ++V    G +  Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439

Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
           F+G+  G + K +      S+   V ++EE++ ++           + V +L LD     
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498

Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVSLYQPQLATRPWIQ 567
           LY A  S ++++P++ C  Y SC   C+ +RDPYC W S  SC  V+   P +    + Q
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT---PGMLAEGYEQ 555

Query: 568 DIEGASAKDLCSASSVVSPSFVP 590
           D E  +   L     ++  S  P
Sbjct: 556 DTEFGNTAHLGDCHEILPTSTTP 578


>gi|19718780 semaphorin 6B precursor [Homo sapiens]
          Length = 888

 Score =  263 bits (671), Expect = 7e-70
 Identities = 213/614 (34%), Positives = 298/614 (48%), Gaps = 78/614 (12%)

Query: 18  ALPPRPPLLLLLLLL-----LLLQPPPPTWALSPRISL---PLGSEERPFLRFEAEHISN 69
           A PPRP LLLLLLLL     L  + PPP  +++PR  L   P+     P     AE   +
Sbjct: 6   ASPPRPALLLLLLLLGGAHGLFPEEPPPL-SVAPRDYLNHYPVFVGSGPGRLTPAEGADD 64

Query: 70  YTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQ-ELLWGADAEKKQQCSFKGKDPQ 128
                + R  RTL++G R+ L+ +           YQ +L W ++      C  KGK  +
Sbjct: 65  LNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQ-E 123

Query: 129 RDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFD 188
            +C+N++K+LL    S LF CG+ AF+P+C   +++      D   N+    G  RCP+D
Sbjct: 124 GECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQPVGD---NI---SGMARCPYD 177

Query: 189 PNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT--KTESSLNWLQDPAFVASAYI 246
           P   + AL  DG L+T TV+ F   D  I RS   RPT    +    W ++P FV +   
Sbjct: 178 PKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAV-- 235

Query: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGE-RVLQQRWTSFLK 305
               GS       +YFFF E   EF + E  +VSR+AR+CK D GG  RVL+++WTSFLK
Sbjct: 236 --EWGS------HVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLK 287

Query: 306 AQLLCSRPDDG-FPFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVF 361
           A+L CS P D  F FNVLQ    V +L   P      +   VF++     +  GSAVC F
Sbjct: 288 ARLNCSVPGDSHFYFNVLQAVTGVVSLGGRP------VVLAVFSTP--SNSIPGSAVCAF 339

Query: 362 TMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKINSSLQLPDRVL 420
            +  V  VF G ++E       W  V    VP PRPG C   +A   + N+S  LPD +L
Sbjct: 340 DLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCC---AAPGMQYNASSALPDDIL 396

Query: 421 NFLKDHFLMDGQVRS---RMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLHK 475
           NF+K H LMD  V S      +L+   R+Q  RVAV    G      V+FLG+  G + K
Sbjct: 397 NFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLK 456

Query: 476 AVSVGPRVH---------IIEELQIF-----------SSGQPVQNLLLDTHRGLLYAASH 515
            + V P             +EE + +            +GQ + +L LD   G L AA  
Sbjct: 457 FL-VRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFP 515

Query: 516 SGVVQVPMANCSLYRSC-GDCLLARDPYCAWS-GSSCKHVSLYQPQLATRPWIQDIEGAS 573
             VV+VP+A C  Y  C  +C+ ++DPYC W+   SC    ++        + QD+ GAS
Sbjct: 516 RCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSC----IFLSPGTRAAFEQDVSGAS 571

Query: 574 AKDLCSASSVVSPS 587
              L   + ++  S
Sbjct: 572 TSGLGDCTGLLRAS 585


>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
          Length = 597

 Score =  261 bits (666), Expect = 2e-69
 Identities = 186/565 (32%), Positives = 284/565 (50%), Gaps = 72/565 (12%)

Query: 63  EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
           E++H  ++  +L  RD  TLY+  R+ ++ +  NL+ +P  E    ++L W +  + ++ 
Sbjct: 52  ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107

Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
           C+ KGK    +C N+IK+ +P +   +F CGT AF+PMC Y  +       +E       
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161

Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
            G  RCPFD    + AL  DG+LY+ TV+ F  +D  I RS     +LR  K +S   W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218

Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
           ++P F+ +              + +YFFF E   E       + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268

Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
           VL++ WTSFLKA+L CS P D F  F+VLQ   D+  ++  P         GVFT+Q + 
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321

Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
            +  GSAVC F+M D+++VF G +KE       W  V    VP PRPG C  +   E   
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379

Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
            +S+  PD  L+F+K H LMD  V          + + RY+   ++V    G +  Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439

Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
           F+G+  G + K +      S+   V ++EE++ ++           + V +L LD     
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498

Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVSLYQPQLATRPWIQ 567
           LY A  S ++++P++ C  Y SC   C+ +RDPYC W S  SC  V+   P +    + Q
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT---PGMLAEGYEQ 555

Query: 568 DIEGASAKDLCSASSV-VSPSFVPT 591
           D E  +   L     + VS S V T
Sbjct: 556 DTEFGNTAHLGDCHDMEVSSSSVTT 580


>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
          Length = 998

 Score =  260 bits (664), Expect = 4e-69
 Identities = 180/543 (33%), Positives = 276/543 (50%), Gaps = 71/543 (13%)

Query: 63  EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
           E++H  ++  +L  RD  TLY+  R+ ++ +  NL+ +P  E    ++L W +  + ++ 
Sbjct: 52  ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107

Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
           C+ KGK    +C N+IK+ +P +   +F CGT AF+PMC Y  +       +E       
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161

Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
            G  RCPFD    + AL  DG+LY+ TV+ F  +D  I RS     +LR  K +S   W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218

Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
           ++P F+ +              + +YFFF E   E       + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268

Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
           VL++ WTSFLKA+L CS P D F  F+VLQ   D+  ++  P         GVFT+Q + 
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321

Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
            +  GSAVC F+M D+++VF G +KE       W  V    VP PRPG C  +   E   
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379

Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
            +S+  PD  L+F+K H LMD  V          + + RY+   ++V    G +  Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439

Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
           F+G+  G + K +      S+   V ++EE++ ++           + V +L LD     
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498

Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVSLYQPQLATRPWIQ 567
           LY A  S ++++P++ C  Y SC   C+ +RDPYC W S  SC  V+   P +    + Q
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT---PGMLAEGYEQ 555

Query: 568 DIE 570
           D E
Sbjct: 556 DTE 558


>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
          Length = 1011

 Score =  258 bits (660), Expect = 1e-68
 Identities = 176/527 (33%), Positives = 270/527 (51%), Gaps = 68/527 (12%)

Query: 63  EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
           E++H  ++  +L  RD  TLY+  R+ ++ +  NL+ +P  E    ++L W +  + ++ 
Sbjct: 52  ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107

Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
           C+ KGK    +C N+IK+ +P +   +F CGT AF+PMC Y  +       +E       
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161

Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
            G  RCPFD    + AL  DG+LY+ TV+ F  +D  I RS     +LR  K +S   W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218

Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
           ++P F+ +              + +YFFF E   E       + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268

Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
           VL++ WTSFLKA+L CS P D F  F+VLQ   D+  ++  P         GVFT+Q + 
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321

Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
            +  GSAVC F+M D+++VF G +KE       W  V    VP PRPG C  +   E   
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379

Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
            +S+  PD  L+F+K H LMD  V          + + RY+   ++V    G +  Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439

Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
           F+G+  G + K +      S+   V ++EE++ ++           + V +L LD     
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498

Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVS 554
           LY A  S ++++P++ C  Y SC   C+ +RDPYC W S  SC  V+
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT 545


>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
          Length = 1151

 Score =  253 bits (647), Expect = 4e-67
 Identities = 176/522 (33%), Positives = 257/522 (49%), Gaps = 53/522 (10%)

Query: 69  NYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDP 127
           +++ L L   G  L VGAR  LF LS +N+S L   E     W +  + ++ C  KGK  
Sbjct: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATE-----WASSEDTRRSCQSKGKT- 178

Query: 128 QRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPF 187
           + +CQNY+++L+ ++G  +F CGT AFSPMCT   + N +   ++       +G  RCP+
Sbjct: 179 EEECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKI------NGVARCPY 231

Query: 188 DPNFKSTALVVD-GELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN--WLQDPAFVASA 244
           DP   STA++   GELY  TV  F G DPAI RS    P    +  N  WL +P FVA A
Sbjct: 232 DPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVA-A 290

Query: 245 YIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFL 304
           Y    +G         YFF  E   E +    T+ SR+AR+CK D GG  +L+  WT+F+
Sbjct: 291 Y---DIGLFA------YFFLRENAVEHDC-GRTVYSRVARVCKNDVGGRFLLEDTWTTFM 340

Query: 305 KAQLLCSRPDD-GFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
           KA+L CSRP +  F +N LQ  F L          L YGVFT+  +  +   SAVC F +
Sbjct: 341 KARLNCSRPGEVPFYYNELQSAFHLP------EQDLIYGVFTT--NVNSIAASAVCAFNL 392

Query: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
             + + F+G ++        W  + +P+P  + G        E     SLQ   R+    
Sbjct: 393 SAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRL---- 448

Query: 424 KDHFLMDGQVR---SRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480
              FLM   V+       + Q   R+  + V  V      Y VL++GT  G + KA+S  
Sbjct: 449 ---FLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTA 505

Query: 481 PR-VH--IIEELQIFSSG--QPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDC 535
            R +H   +EEL +   G  +P+++L +      L+     GV++VP+  C+ YRS G C
Sbjct: 506 SRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGAC 565

Query: 536 LLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDL 577
           L ARDPYC W G   +  S  +       W Q+I     +++
Sbjct: 566 LGARDPYCGWDGKQ-QRCSTLEDSSNMSLWTQNITACPVRNV 606


>gi|16306552 semaphorin Y [Homo sapiens]
          Length = 930

 Score =  246 bits (627), Expect = 8e-65
 Identities = 194/570 (34%), Positives = 277/570 (48%), Gaps = 71/570 (12%)

Query: 21  PRPPLLLLLLLLLLLQPPPPTWALSPRISLPL------GSEERPFLR-FEAEHISNYTAL 73
           PR P  + LLLLLLL   P T A  P+  LPL      G+    + R  E + ++    L
Sbjct: 2   PRAPHFMPLLLLLLLLSLPHTQAAFPQDPLPLLISDLQGTSPLSWFRGLEDDAVAAELGL 61

Query: 74  LLSRD---GRTLYVGAREALFALSSNLSFLPGGE----YQELLWGADAEKKQQCSFKGKD 126
              R     RTL V AR+ +F  S +L     GE     + L W +  +  + C+ +GK 
Sbjct: 62  DFQRFLTLNRTLLVAARDHVF--SFDLQAEEEGEGLVPNKYLTWRS--QDVENCAVRGKL 117

Query: 127 PQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCP 186
              +C NYI++L+P     L  CGT +FSP+C    + +      ++G  L   G+ RCP
Sbjct: 118 TD-ECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSL----QQEGEEL--SGQARCP 170

Query: 187 FDPNFKSTALVVDGELYTGTVSSFQGNDPAISRS----QSLRPTKTESSLNWLQDPAFVA 242
           FD    + A+  +G LY+ T + FQ +D  + RS      LR  K +S   WL++P FV 
Sbjct: 171 FDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDS--KWLREPHFVQ 228

Query: 243 SAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGE-RVLQQRWT 301
           +              D +YFFF E   E         SR+AR+CK D GG  R L + WT
Sbjct: 229 AL----------EHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWT 278

Query: 302 SFLKAQLLCSRPDDG-FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
           SFLK +L CS P D  F F+VLQ +    P     R  LF GVFT+Q    +  GSAVC 
Sbjct: 279 SFLKLRLNCSVPGDSTFYFDVLQAL--TGPVNLHGRSALF-GVFTTQ--TNSIPGSAVCA 333

Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHP-VPTPRPGACITNSARERKINSSLQLPDRV 419
           F + +++R F G +KE       W  V+   VP+PRPG+C          +SS  LPD V
Sbjct: 334 FYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSC-AGVGGAALFSSSRDLPDDV 392

Query: 420 LNFLKDHFLMDGQV----RSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHK 475
           L F+K H L+D  V       +L L  +A   +VAV  + G H    V+FLG+ DG + K
Sbjct: 393 LTFIKAHPLLDPAVPPVTHQPLLTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLK 452

Query: 476 AV-----SVGPRVHIIEELQIFS-----------SGQPVQNLLLDTHRGLLYAASHSGVV 519
            +     S GP   ++EE+  +S           + + +  L LDT    L+ A    +V
Sbjct: 453 VLTPGGRSGGPEPILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIV 512

Query: 520 QVPMANCSLYRSC-GDCLLARDPYCAWSGS 548
            +P++ C+ + +C   CL ++DPYC W  S
Sbjct: 513 YLPLSRCARHGACQRSCLASQDPYCGWHSS 542


>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
           domain, (semaphorin) 6A [Homo sapiens]
          Length = 1030

 Score =  243 bits (621), Expect = 4e-64
 Identities = 170/506 (33%), Positives = 252/506 (49%), Gaps = 58/506 (11%)

Query: 81  TLYVGAREALFALSSNLSFLPGGEY-QELLWGADAEKKQQCSFKGKDPQRDCQNYIKILL 139
           TLY+ AR+ ++ +  + S        ++L W +       C  KGK    +C N+IK+LL
Sbjct: 67  TLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKVLL 125

Query: 140 PLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVD 199
             +   LF CGT AF+P C    M+      DE        G  RCP+D    + AL  D
Sbjct: 126 KKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFS------GMARCPYDAKHANVALFAD 179

Query: 200 GELYTGTVSSFQGNDPAISRSQSLRPT--KTESSLNWLQDPAFVASAYIPESLGSLQGDD 257
           G+LY+ TV+ F   D  I RS    PT    +    WL++P FV +              
Sbjct: 180 GKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAV----------DYG 229

Query: 258 DKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ERVLQQRWTSFLKAQLLCSRPDDG 316
           D IYFFF E   E+      +  R+A++CK D GG +RVL+++WTSFLKA+L CS P D 
Sbjct: 230 DYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDS 289

Query: 317 -FPFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSG 372
            F FN+LQ   DV  +     + RD +    F++ ++  +  GSAVC + M D+  VF+G
Sbjct: 290 HFYFNILQAVTDVIRI-----NGRDVVL-ATFSTPYN--SIPGSAVCAYDMLDIASVFTG 341

Query: 373 LYKEVNRETQQWYTV-THPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDG 431
            +KE       W  V    VP PRPG C  +S+ ER   S+ + PD  LNF+K H LMD 
Sbjct: 342 RFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSN-EFPDDTLNFIKTHPLMDE 400

Query: 432 QVRS---RMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS-VGPRVHI 485
            V S   R   L+   RY+  ++AV    G +  + V+FLG+  G + K ++ +G    +
Sbjct: 401 AVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFL 460

Query: 486 -----IEELQIFSS---------GQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRS 531
                +EE+ +++S          + +  + LD     LY A  + V++VP+  C  +  
Sbjct: 461 NDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGK 520

Query: 532 C-GDCLLARDPYCAW--SGSSCKHVS 554
           C   C+ +RDPYC W   G +C H+S
Sbjct: 521 CKKTCIASRDPYCGWIKEGGACSHLS 546


>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score =  240 bits (612), Expect = 5e-63
 Identities = 171/531 (32%), Positives = 259/531 (48%), Gaps = 49/531 (9%)

Query: 58  PFLR-FEAEHISNYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAE 115
           P+LR F A++  +++ L      + L VGAR  LF L   +LS +     Q + W  D  
Sbjct: 45  PWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLI-----QAVEWECDEA 99

Query: 116 KKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGN 175
            K+ C  KGK  + +CQNYI++LL + G  LFTCGT AF+P+CT  ++ N T   D+   
Sbjct: 100 TKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQIS- 156

Query: 176 VLLEDGKGRCPFDPNFKSTALVV-DGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN- 233
                G  RCP+ P   STAL+   GELY  T   F G DPAI RS  + P    +  N 
Sbjct: 157 -----GMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNS 211

Query: 234 -WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG 292
            WL +P FV+S  I           +  YFFF E   E +  + T+ SR AR+CK D GG
Sbjct: 212 KWLNEPNFVSSYDI----------GNFTYFFFRENAVEHDCGK-TVFSRAARVCKNDIGG 260

Query: 293 ERVLQQRWTSFLKAQLLCSRPDD-GFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRG 351
             +L+  WT+F+KA+L CSRP +  F +N LQ  F L          L YG+FT+  +  
Sbjct: 261 RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL------DLIYGIFTT--NVN 312

Query: 352 TTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINS 411
           +   SAVCVF +  + + FSG +K        W     P P P P        +   +N 
Sbjct: 313 SIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWL----PYPNPNPHFQCGTVDQGLYVNL 368

Query: 412 SLQLPDRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDG 471
           + +       F+  H ++   V +    ++  +R+  VAV  V G      +++L T  G
Sbjct: 369 TERNLQDAQKFILMHEVVQ-PVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYG 427

Query: 472 RLHKA---VSVGPRVHIIEELQIFSS--GQPVQNLLLDTHRGLLYAASHSGVVQVPMANC 526
            + K    ++      ++EE+++F     +P+++L +   + +L+      VV++P+  C
Sbjct: 428 TIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487

Query: 527 SLYRSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDL 577
             YR+   C+ A+DPYC W     K  SL +  L+   W Q I     ++L
Sbjct: 488 QFYRTRSTCIGAQDPYCGWDVVMKKCTSL-EESLSMTQWEQSISACPTRNL 537


>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
          Length = 666

 Score =  233 bits (594), Expect = 6e-61
 Identities = 211/694 (30%), Positives = 302/694 (43%), Gaps = 97/694 (13%)

Query: 13  AAPWGALPPRP-----PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL------- 60
           +AP   +P  P     PL L LLLLL        WA +      L S  R F        
Sbjct: 12  SAPRARVPGPPARLGLPLRLRLLLLL--------WAAAASAQGHLRSGPRIFAVWKGHVG 63

Query: 61  --RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQ 118
             R +      +T L       +++VG R  ++         P G+   +        K 
Sbjct: 64  QDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFD-----FPEGKNASVRTVNIGSTKG 118

Query: 119 QCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLL 178
            C  K     RDC+NYI  LL      L  CGT A  P C   N+ N T+       V L
Sbjct: 119 SCLDK-----RDCENYIT-LLERRSEGLLACGTNARHPSCW--NLVNGTV-------VPL 163

Query: 179 EDGKGRCPFDPNFKSTALVVDGELY-TGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQD 237
            + +G  PF P+  S  L    E+Y T     + G  P   R +      T  ++  +Q+
Sbjct: 164 GEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQN 221

Query: 238 PAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQ 297
           P F+ +  + +     Q  DDKIY+FF E   +        VSR+A++C+GD+GGE  L 
Sbjct: 222 PQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLS 277

Query: 298 -QRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGS 356
             +W +FLKA L+CS       FN LQDVF L      WRDT  YGVF++ W+      S
Sbjct: 278 VSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----S 332

Query: 357 AVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLP 416
           AVCV+++ D+ +VF          T         +P PRPG C+ +  ++     + Q+ 
Sbjct: 333 AVCVYSLGDIDKVF---------RTSSLKGYHSSLPNPRPGKCLPD--QQPIPTETFQVA 381

Query: 417 DRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHK 475
           DR     +    ++     +  L   +  YQ+VAVHR+   H  T+ VL+L T  G +HK
Sbjct: 382 DRHPEVAQ---RVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHK 438

Query: 476 AVSVGPRVHI----IEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-R 530
            V  G + H     I E+Q F     +Q + LD  R  LY +S   V QVP+  C +Y  
Sbjct: 439 VVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGG 498

Query: 531 SCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVP 590
            C  CL++RDPYC W    C  +S+Y  +   R  +Q I  A     C       P+  P
Sbjct: 499 GCHGCLMSRDPYCGWDQGRC--ISIYSSE---RSVLQSINPAEPHKEC-------PNPKP 546

Query: 591 TGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASC---HVLPTGDLLL-- 645
             + P ++V   PN+   L+CP+ S  AT  W       N   SC   H  P   L +  
Sbjct: 547 -DKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHK---ENVEQSCEPGHQSPNCILFIEN 602

Query: 646 VGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGV 679
           +  QQ G + C   +EG     A +   + EDG+
Sbjct: 603 LTAQQYGHYFC-EAQEGSYFREAQHWQLLPEDGI 635


>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
          Length = 652

 Score =  228 bits (581), Expect = 2e-59
 Identities = 182/570 (31%), Positives = 262/570 (45%), Gaps = 65/570 (11%)

Query: 123 KGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGK 182
           K    + DC+NYI  LL      L  CGT A  P C   N+ N T+       V L + +
Sbjct: 104 KNASVRTDCENYIT-LLERRSEGLLACGTNARHPSCW--NLVNGTV-------VPLGEMR 153

Query: 183 GRCPFDPNFKSTALVVDGELY-TGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFV 241
           G  PF P+  S  L    E+Y T     + G  P   R +      T  ++  +Q+P F+
Sbjct: 154 GYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQNPQFI 211

Query: 242 ASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQ-QRW 300
            +  + +     Q  DDKIY+FF E   +        VSR+A++C+GD+GGE  L   +W
Sbjct: 212 KATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKW 267

Query: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
            +FLKA L+CS       FN LQDVF L      WRDT  YGVF++ W+      SAVCV
Sbjct: 268 NTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----SAVCV 322

Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
           +++ D+ +VF          T         +P PRPG C+ +  ++     + Q+ DR  
Sbjct: 323 YSLGDIDKVF---------RTSSLKGYHSSLPNPRPGKCLPD--QQPIPTETFQVADRHP 371

Query: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSV 479
              +    ++     +  L   +  YQ+VAVHR+   H  T+ VL+L T  G +HK V  
Sbjct: 372 EVAQ---RVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEP 428

Query: 480 GPRVHI----IEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCGD 534
           G + H     I E+Q F     +Q + LD  R  LY +S   V QVP+  C +Y   C  
Sbjct: 429 GEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHG 488

Query: 535 CLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEK 594
           CL++RDPYC W    C  +S+Y  +   R  +Q I  A     C       P+  P  + 
Sbjct: 489 CLMSRDPYCGWDQGRC--ISIYSSE---RSVLQSINPAEPHKEC-------PNPKP-DKA 535

Query: 595 PCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASC---HVLPTGDLLL--VGTQ 649
           P ++V   PN+   L+CP+ S  AT  W       N   SC   H  P   L +  +  Q
Sbjct: 536 PLQKVSLAPNSRYYLSCPMESRHATYSWRHK---ENVEQSCEPGHQSPNCILFIENLTAQ 592

Query: 650 QLGEFQCWSLEEGFQQLVASYCPEVVEDGV 679
           Q G + C   +EG     A +   + EDG+
Sbjct: 593 QYGHYFC-EAQEGSYFREAQHWQLLPEDGI 621


>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
          Length = 476

 Score =  223 bits (568), Expect = 6e-58
 Identities = 148/434 (34%), Positives = 225/434 (51%), Gaps = 50/434 (11%)

Query: 63  EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
           E++H  ++  +L  RD  TLY+  R+ ++ +  NL+ +P  E    ++L W +  + ++ 
Sbjct: 52  ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107

Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
           C+ KGK    +C N+IK+ +P +   +F CGT AF+PMC Y  +       +E       
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161

Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
            G  RCPFD    + AL  DG+LY+ TV+ F  +D  I RS     +LR  K +S   W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218

Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
           ++P F+ +              + +YFFF E   E       + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268

Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
           VL++ WTSFLKA+L CS P D F  F+VLQ   D+  ++  P         GVFT+Q + 
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321

Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
            +  GSAVC F+M D+++VF G +KE       W  V    VP PRPG C  +   E   
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379

Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
            +S+  PD  L+F+K H LMD  V          + + RY+   ++V    G +  Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439

Query: 465 FLGTGDGRLHKAVS 478
           F+G+  G + K ++
Sbjct: 440 FVGSEAGMVLKVLA 453


>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
          Length = 501

 Score =  210 bits (535), Expect = 4e-54
 Identities = 162/511 (31%), Positives = 237/511 (46%), Gaps = 55/511 (10%)

Query: 182 KGRCPFDPNFKSTALVVDGELY-TGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240
           +G  PF P+  S  L    E+Y T     + G  P   R +      T  ++  +Q+P F
Sbjct: 2   RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQNPQF 59

Query: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQ-QR 299
           + +  + +     Q  DDKIY+FF E   +        VSR+A++C+GD+GGE  L   +
Sbjct: 60  IKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSK 115

Query: 300 WTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVC 359
           W +FLKA L+CS       FN LQDVF L      WRDT  YGVF++ W+      SAVC
Sbjct: 116 WNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----SAVC 170

Query: 360 VFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRV 419
           V+++ D+ +VF          T         +P PRPG C+ +  ++     + Q+ DR 
Sbjct: 171 VYSLGDIDKVF---------RTSSLKGYHSSLPNPRPGKCLPD--QQPIPTETFQVADRH 219

Query: 420 LNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVS 478
               +    ++     +  L   +  YQ+VAVHR+   H  T+ VL+L T  G +HK V 
Sbjct: 220 PEVAQ---RVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE 276

Query: 479 VGPRVHI----IEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCG 533
            G + H     I E+Q F     +Q + LD  R  LY +S   V QVP+  C +Y   C 
Sbjct: 277 PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCH 336

Query: 534 DCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGE 593
            CL++RDPYC W    C  +S+Y  +   R  +Q I  A     C       P+  P  +
Sbjct: 337 GCLMSRDPYCGWDQGRC--ISIYSSE---RSVLQSINPAEPHKEC-------PNPKP-DK 383

Query: 594 KPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASC---HVLPTGDLLL--VGT 648
            P ++V   PN+   L+CP+ S  AT  W       N   SC   H  P   L +  +  
Sbjct: 384 APLQKVSLAPNSRYYLSCPMESRHATYSWRHK---ENVEQSCEPGHQSPNCILFIENLTA 440

Query: 649 QQLGEFQCWSLEEGFQQLVASYCPEVVEDGV 679
           QQ G + C   +EG     A +   + EDG+
Sbjct: 441 QQYGHYFC-EAQEGSYFREAQHWQLLPEDGI 470


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,056,066
Number of Sequences: 37866
Number of extensions: 1911176
Number of successful extensions: 5977
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 5518
Number of HSP's gapped (non-prelim): 179
length of query: 837
length of database: 18,247,518
effective HSP length: 111
effective length of query: 726
effective length of database: 14,044,392
effective search space: 10196228592
effective search space used: 10196228592
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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