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Search of human proteins with 39777608
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39777608 semaphorin 4B precursor [Homo sapiens]
(837 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39777610 semaphorin 4B precursor [Homo sapiens] 1714 0.0
gi|39777608 semaphorin 4B precursor [Homo sapiens] 1714 0.0
gi|157388902 semaphorin 4C [Homo sapiens] 480 e-135
gi|21361914 semaphorin B [Homo sapiens] 471 e-133
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 459 e-129
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 456 e-128
gi|28872814 semaphorin 4G [Homo sapiens] 394 e-109
gi|19923279 semaphorin W [Homo sapiens] 391 e-108
gi|5174673 semaphorin 3A precursor [Homo sapiens] 324 2e-88
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 314 2e-85
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 314 2e-85
gi|41406086 semaphorin 3D [Homo sapiens] 313 3e-85
gi|9910362 semaphorin sem2 [Homo sapiens] 313 3e-85
gi|5454048 semaphorin 3C [Homo sapiens] 311 1e-84
gi|188497703 semaphorin 3F [Homo sapiens] 294 3e-79
gi|6912650 semaphorin 3E [Homo sapiens] 290 4e-78
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 265 2e-70
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 263 7e-70
gi|19718780 semaphorin 6B precursor [Homo sapiens] 263 7e-70
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 261 2e-69
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 260 4e-69
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 258 1e-68
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 253 4e-67
gi|16306552 semaphorin Y [Homo sapiens] 246 8e-65
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 243 4e-64
gi|147904700 semaphorin 5A [Homo sapiens] 240 5e-63
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 233 6e-61
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 228 2e-59
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 223 6e-58
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 210 4e-54
>gi|39777610 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 1714 bits (4438), Expect = 0.0
Identities = 837/837 (100%), Positives = 837/837 (100%)
Query: 1 MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL 60
MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL
Sbjct: 1 MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL 60
Query: 61 RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC 120
RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC
Sbjct: 61 RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC 120
Query: 121 SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED 180
SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED
Sbjct: 121 SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED 180
Query: 181 GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240
GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF
Sbjct: 181 GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240
Query: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW 300
VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW
Sbjct: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW 300
Query: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV
Sbjct: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL
Sbjct: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
Query: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480
NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG
Sbjct: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480
Query: 481 PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD 540
PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD
Sbjct: 481 PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD 540
Query: 541 PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ 600
PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ
Sbjct: 541 PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ 600
Query: 601 FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE 660
FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE
Sbjct: 601 FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE 660
Query: 661 EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV 720
EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV
Sbjct: 661 EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV 720
Query: 721 MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST 780
MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST
Sbjct: 721 MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST 780
Query: 781 PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV 837
PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV
Sbjct: 781 PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV 837
>gi|39777608 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 1714 bits (4438), Expect = 0.0
Identities = 837/837 (100%), Positives = 837/837 (100%)
Query: 1 MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL 60
MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL
Sbjct: 1 MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL 60
Query: 61 RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC 120
RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC
Sbjct: 61 RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC 120
Query: 121 SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED 180
SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED
Sbjct: 121 SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED 180
Query: 181 GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240
GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF
Sbjct: 181 GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240
Query: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW 300
VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW
Sbjct: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW 300
Query: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV
Sbjct: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL
Sbjct: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
Query: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480
NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG
Sbjct: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480
Query: 481 PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD 540
PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD
Sbjct: 481 PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD 540
Query: 541 PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ 600
PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ
Sbjct: 541 PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ 600
Query: 601 FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE 660
FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE
Sbjct: 601 FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE 660
Query: 661 EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV 720
EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV
Sbjct: 661 EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV 720
Query: 721 MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST 780
MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST
Sbjct: 721 MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST 780
Query: 781 PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV 837
PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV
Sbjct: 781 PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV 837
>gi|157388902 semaphorin 4C [Homo sapiens]
Length = 833
Score = 480 bits (1236), Expect = e-135
Identities = 300/740 (40%), Positives = 401/740 (54%), Gaps = 63/740 (8%)
Query: 42 WALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLP 101
W L PR ++ G RF I ++ L L+ LYVGAREALFA S L
Sbjct: 25 WNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQ 84
Query: 102 GGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYI 161
G + W A EKK +C KGK+ Q +C N+I+ L P + SHL+ CGT AF P CTY+
Sbjct: 85 GA----ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYV 140
Query: 162 NMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ 221
NM FTL E EDGKG+CP+DP L+VDGELY+ T+++F G +P I R+
Sbjct: 141 NMLTFTLEHGE-----FEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNM 195
Query: 222 SLRPT-KTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVS 280
+ KTE WL +P FV SAY+PES+GS GDDDK+YFFF E E + + +V+
Sbjct: 196 GPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVA 255
Query: 281 RIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLF 340
R+AR+CKGD GG R LQ++WT+FLKA+L CS P+ FN LQ + TL + W +T F
Sbjct: 256 RVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDT--SWHNTTF 313
Query: 341 YGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACI 400
+GVF +QW G SA+C + ++++QRVF G YKE + E Q+W T PVP+PRPG+CI
Sbjct: 314 FGVFQAQW--GDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCI 371
Query: 401 TNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---SRMLLLQPQARYQRVAVHRVPGL 457
N R SSL+LPD +LNF+K H LM+ QV SR LL++ + + RV GL
Sbjct: 372 NNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGL 431
Query: 458 H-HTYDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHS 516
TY VLF+GTGDG L KAVS+GP VH+IEELQ+F +P+++L+L + LL+A S S
Sbjct: 432 DGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQ-EPMRSLVLSQSKKLLFAGSRS 490
Query: 517 GVVQVPMANCSLYRSCGDCLLARDPYCAWS--GSSCKHVSLYQPQLATRPWIQDIEGASA 574
+VQ+P+A+C YRSC DC+LARDPYCAWS S C V + L IQ + +
Sbjct: 491 QLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLL----IQHVMTSDT 546
Query: 575 KDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASAS 634
+C+ S PT + + T L C L SNLA W G + A
Sbjct: 547 SGICNLRG--SKKVRPTP----KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP 600
Query: 635 CHVLPTGDL-----LLVGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTDEGGSV 689
L L + + G + C+S E+G + Y VV G SV
Sbjct: 601 GSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVV---------AGPSV 651
Query: 690 PVIISTSRVSAPAGGKASWGADRSYWKEFLVMCTLFVL-AVLLPVLFLLYRHRNSMKVFL 748
T AP LV + L AV L +L L+ R ++ L
Sbjct: 652 -----TLEARAPLENLG------------LVWLAVVALGAVCLVLLLLVLSLRRRLREEL 694
Query: 749 KQGECASVHPKTCPVVLPPE 768
++G A+ P+ LP E
Sbjct: 695 EKGAKATERTLVYPLELPKE 714
>gi|21361914 semaphorin B [Homo sapiens]
Length = 761
Score = 471 bits (1213), Expect = e-133
Identities = 297/760 (39%), Positives = 422/760 (55%), Gaps = 59/760 (7%)
Query: 18 ALPPRPPLLLLLLLLLLLQPPPPTWALS-------PRISLPLGSEERPFLRFEAEHISNY 70
AL P LL L L LLQ PT PR+ G E R F + + ++
Sbjct: 5 ALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDF 64
Query: 71 TALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRD 130
LLLS DG TLYVGAREA+ AL +P + + W A KK +C+FK K +
Sbjct: 65 DTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNM-IPWPASDRKKSECAFKKKSNETQ 123
Query: 131 CQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPN 190
C N+I++L+ + +HL+TCGT AFSP CT+I +++ L + V+ +GKG+ PFDP
Sbjct: 124 CFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVM--EGKGQSPFDPA 181
Query: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTESSLNWLQ-DPAFVASAYIPE 248
K TA++VDG LY+GT+++F G++P + R+ +P KT++ L WL D +FVA+ IP
Sbjct: 182 HKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA--IPS 239
Query: 249 SLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQL 308
+ +YFFF ET EF+FFE SR+AR+CK D GGE++LQ++WT+FLKAQL
Sbjct: 240 T--------QVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQL 291
Query: 309 LCSRPDDGFPFNVLQDVFTL---SPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365
LC++P PFNV++ L SP+ Y VFTSQW G T SAVC F++ D
Sbjct: 292 LCTQPGQ-LPFNVIRHAVLLPADSPTAPH-----IYAVFTSQWQVGGTRSSAVCAFSLLD 345
Query: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425
++RVF G YKE+N+ET +W T P PRPG+C + D+ L F+KD
Sbjct: 346 IERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPS-----------SDKALTFMKD 394
Query: 426 HFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSVG-PRV 483
HFLMD QV LL++ Y R+AV GL H++ V++LGT G LHKAV G
Sbjct: 395 HFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSA 454
Query: 484 HIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYC 543
H++EE+Q+F +PV+NL L +G ++ GV +VP ANCS+Y SC DC+LARDP+C
Sbjct: 455 HLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHC 514
Query: 544 AWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGE-KPCEQVQFQ 602
AW S L P L W QD+E + + C AS +S S P + ++V
Sbjct: 515 AWDPESRTCCLLSAPNL--NSWKQDMERGNPEWAC-ASGPMSRSLRPQSRPQIIKEVLAV 571
Query: 603 PNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGE-FQCWSLEE 661
PN++ L CP LS LA+ W A V ++S + G LLL+ +G +QCW+ E
Sbjct: 572 PNSILELPCPHLSALASYYWSHGPAAVPEASS--TVYNGSLLLIVQDGVGGLYQCWATEN 629
Query: 662 GFQQLVASYCPEVVEDGVADQTDEGGSVP---VIISTSRVSAPAGGKASWGADRSYWKEF 718
GF V SY + + +A + G +P V + +RVS G A+ A +SYW F
Sbjct: 630 GFSYPVISYWVDSQDQTLALDPELAG-IPREHVKVPLTRVS----GGAALAAQQSYWPHF 684
Query: 719 LVMCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHP 758
+ + LF L + ++ L+ +++ K C ++ P
Sbjct: 685 VTVTVLFALVLSGALIILVASPLRALRARGKVQGCETLRP 724
>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
Length = 862
Score = 459 bits (1182), Expect = e-129
Identities = 278/669 (41%), Positives = 389/669 (58%), Gaps = 46/669 (6%)
Query: 24 PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLY 83
P+ LL+ L ++ +A PRI+ E ++F I NY+ALLLS D TLY
Sbjct: 6 PIRGLLMALAVMFGTAMAFAPIPRITWE--HREVHLVQFHEPDIYNYSALLLSEDKDTLY 63
Query: 84 VGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLS 142
+GAREA+FA+++ N+S + E+ W +KK +C+ KGK Q +C NYI++L PLS
Sbjct: 64 IGAREAVFAVNALNIS----EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119
Query: 143 GSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGEL 202
+ L+ CGT AF P C ++N+ +F EDGKGRCPFDP T+++VDGEL
Sbjct: 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKN------EDGKGRCPFDPAHSYTSVMVDGEL 173
Query: 203 YTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYF 262
Y+GT +F G++P ISR+ S P +TE ++ WL +P+FV + I +S S G+DD++YF
Sbjct: 174 YSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233
Query: 263 FFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVL 322
FF+E E+EF ++ RIAR+CKGD+GG R LQ++WTSFLKA+L+CSRPD G FNVL
Sbjct: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVL 293
Query: 323 QDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS-GLYKE---VN 378
+DVF L SP + +FY +FT Q + SAVC + + + VFS G Y + V
Sbjct: 294 RDVFVLR-SP-GLKVPVFYALFTPQLN--NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349
Query: 379 RETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---S 435
+ +W PVP PRPGACI + AR SSL LPD+ L F+KDH LMD V +
Sbjct: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409
Query: 436 RMLLLQPQARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSS 494
R L++ Y ++ V R L T YDV+F+ T G LHKA+S+ VHIIEE Q+F
Sbjct: 410 RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQD 469
Query: 495 GQPVQNLLLDTHRG--LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKH 552
+PVQ LLL + +G +YA S+SGVVQ P+A C + +C DC+LARDPYCAWS +
Sbjct: 470 FEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATC 529
Query: 553 VSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACP 612
V+L+Q + +R IQ++ G ++ +C S S Q F+ L C
Sbjct: 530 VALHQTESPSRGLIQEMSGDAS--VCPDKSKGS----------YRQHFFKHGGTAELKCS 577
Query: 613 LLSNLATRLW-LRNGAPVNASASCHVLPTGDLLLVGTQQ--LGEFQCWSLE----EGFQQ 665
SNLA W +NG S ++ +LL+ + G +QC S E + Q
Sbjct: 578 QKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQ 637
Query: 666 LVASYCPEV 674
+VA + EV
Sbjct: 638 VVAKHVLEV 646
>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
Length = 738
Score = 456 bits (1173), Expect = e-128
Identities = 255/570 (44%), Positives = 355/570 (62%), Gaps = 29/570 (5%)
Query: 24 PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLY 83
P+ LL+ L ++ +A PRI+ E ++F I NY+ALLLS D TLY
Sbjct: 6 PIRGLLMALAVMFGTAMAFAPIPRITWE--HREVHLVQFHEPDIYNYSALLLSEDKDTLY 63
Query: 84 VGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLS 142
+GAREA+FA+++ N+S + E+ W +KK +C+ KGK Q +C NYI++L PLS
Sbjct: 64 IGAREAVFAVNALNIS----EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119
Query: 143 GSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGEL 202
+ L+ CGT AF P C ++N+ +F EDGKGRCPFDP T+++VDGEL
Sbjct: 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKN------EDGKGRCPFDPAHSYTSVMVDGEL 173
Query: 203 YTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYF 262
Y+GT +F G++P ISR+ S P +TE ++ WL +P+FV + I +S S G+DD++YF
Sbjct: 174 YSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233
Query: 263 FFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVL 322
FF+E E+EF ++ RIAR+CKGD+GG R LQ++WTSFLKA+L+CSRPD G FNVL
Sbjct: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVL 293
Query: 323 QDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS-GLYKE---VN 378
+DVF L SP + +FY +FT Q + SAVC + + + VFS G Y + V
Sbjct: 294 RDVFVLR-SP-GLKVPVFYALFTPQLN--NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349
Query: 379 RETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---S 435
+ +W PVP PRPGACI + AR SSL LPD+ L F+KDH LMD V +
Sbjct: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409
Query: 436 RMLLLQPQARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSS 494
R L++ Y ++ V R L T YDV+F+ T G LHKA+S+ VHIIEE Q+F
Sbjct: 410 RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQD 469
Query: 495 GQPVQNLLLDTHRG--LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKH 552
+PVQ LLL + +G +YA S+SGVVQ P+A C + +C DC+LARDPYCAWS +
Sbjct: 470 FEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATC 529
Query: 553 VSLYQPQLATRPWIQDIEGASAKDLCSASS 582
V+L+Q + +R IQ++ G ++ +C ASS
Sbjct: 530 VALHQTESPSRGLIQEMSGDAS--VCPASS 557
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 394 bits (1013), Expect = e-109
Identities = 262/681 (38%), Positives = 363/681 (53%), Gaps = 57/681 (8%)
Query: 16 WGALPPRPPLLLLLLLLLLLQPPP----PTWAL--SPRISLPLGSEERPFLRFEAEHISN 69
WG L P LLL +L P P P+ L +PR+++P EE R N
Sbjct: 2 WGRLWP----LLLSILTATAVPGPSLRRPSRELDATPRMTIPY--EELSGTRHFKGQAQN 55
Query: 70 YTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQR 129
Y+ LLL L VGAR ALF+LS+N + G ++E+ W A E + +C KGK+ Q
Sbjct: 56 YSTLLLEEASARLLVGARGALFSLSAN--DIGDGAHKEIHWEASPEMQSKCHQKGKNNQT 113
Query: 130 DCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDP 189
+C N+++ L L+ +HL+ CGT AF P+C I+ E FTL E+GK +CP+DP
Sbjct: 114 ECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAFTLPTS------FEEGKEKCPYDP 167
Query: 190 NFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESS-LNWLQDPAFVASAYIPE 248
T L++DG LYT T F+ + P I RS+ +TE + ++WL D FV S + E
Sbjct: 168 ARGFTGLIIDGGLYTATRYEFR-SIPDIRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRE 226
Query: 249 SLGSLQGDDDKIYFFFSE------TGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTS 302
S S GDDDK+Y+FF+E +G + + V+R+AR+CKGD GG+++LQ++WTS
Sbjct: 227 SKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTS 286
Query: 303 FLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFT 362
FLKA+L+C P + L+ V +L T FY FT T E SA+C +
Sbjct: 287 FLKARLICHIP----LYETLRGVCSLDAETSS--RTHFYAAFTLSTQWKTLEASAICRYD 340
Query: 363 MKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNF 422
+ ++Q VF+G Y E +++W VP PRPG+CIT+S R + NSS LP VL+F
Sbjct: 341 LAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDF 400
Query: 423 LKDHFLMDGQV---RSRMLLLQPQARYQRVAVHRVPG-LHHTYDVLFLGTGDGRLHKAVS 478
+K H LM V R R LLL+ RY + V TYD+LFLGT DG +HKAV
Sbjct: 401 VKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVV 460
Query: 479 VGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLA 538
+G +HIIEE Q+F Q V+NL++ + LY + SGV+Q+P+++CS YRSC DC+LA
Sbjct: 461 LGSGMHIIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSCSRYRSCYDCILA 520
Query: 539 RDPYCAWSGSSCKHVSLYQPQLATR------PWIQDIEGASAKDLCSASSVVSPSFVPTG 592
RDPYC W + H +A R IQDIE + C +S P
Sbjct: 521 RDPYCGWDPGT--HACAAATTIANRSQGSRTALIQDIERGNRG--CESSRDTGP------ 570
Query: 593 EKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQ-- 650
P + L C SNLA LWL NG+ + D LLV Q
Sbjct: 571 PPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNGSMGLSDGQGGYRVGVDGLLVTDAQPE 630
Query: 651 -LGEFQCWSLEEGFQQLVASY 670
G + C++ E G + L+ASY
Sbjct: 631 HSGNYGCYAEENGLRTLLASY 651
>gi|19923279 semaphorin W [Homo sapiens]
Length = 770
Score = 391 bits (1004), Expect = e-108
Identities = 254/670 (37%), Positives = 348/670 (51%), Gaps = 51/670 (7%)
Query: 15 PWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALL 74
P P P LLLL +L PR SLP+ + RF H NY+ LL
Sbjct: 10 PGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLL 69
Query: 75 LSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNY 134
+ TLYVGAR+ +FALS S G + + W +Q C KGK + +C N+
Sbjct: 70 VDPASHTLYVGARDTIFALSLPFS---GERPRRIDWMVPEAHRQNCRKKGKK-EDECHNF 125
Query: 135 IKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKST 194
++IL + SHL TCGT AF P C I++ F LE G+G+CPF+P +S
Sbjct: 126 VQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVER------LESGRGKCPFEPAQRSA 179
Query: 195 ALVVDGELYTGTVSSFQGNDPAISRSQSLRPT--KTESSLNWLQDPAFVAS-AYIPESLG 251
A++ G LY TV ++ G +P I+R+ +T++ +WL PAFVA+ A P G
Sbjct: 180 AVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWG 239
Query: 252 SLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCS 311
GDD+ IYFFF+ET + F+ +E V R+AR+C GD GG + LQQRWT+FLKA LLC
Sbjct: 240 DEDGDDE-IYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCP 298
Query: 312 RPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS 371
P+ G +VLQDV L P +FYG+F+SQW T SAVC F +D++ V +
Sbjct: 299 GPEHGRASSVLQDVAVLRPE-LGAGTPIFYGIFSSQWEGATI--SAVCAFRPQDIRTVLN 355
Query: 372 GLYKEVNRETQQWY-TVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMD 430
G ++E+ + + V + VP PRPG CITN+ + R SSL LPDRVL F++DH LMD
Sbjct: 356 GPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMD 415
Query: 431 GQV---RSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSVGPRVHII 486
V LL+ Y RV HRV L YDVL+LGT DG LH+AV +G ++ ++
Sbjct: 416 RPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVL 475
Query: 487 EELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWS 546
E+L +F QPV+N+ L + L S + V QV NC +SC +C+LA+DP CAWS
Sbjct: 476 EDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWS 533
Query: 547 ---GSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCE-QVQFQ 602
H + R +QDIE A LC GE+P +V
Sbjct: 534 FRLDECVAHAGEH------RGLVQDIESADVSSLCPKE---------PGERPVVFEVPVA 578
Query: 603 PNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLL--LVGTQQLGEFQCWSLE 660
L C S A+ +W + P +A + P D L +V +G + C E
Sbjct: 579 TAAHVVLPCSPSSAWASCVWHQ---PSGVTA---LTPRRDGLEVVVTPGAMGAYACECQE 632
Query: 661 EGFQQLVASY 670
G +VA+Y
Sbjct: 633 GGAAHVVAAY 642
>gi|5174673 semaphorin 3A precursor [Homo sapiens]
Length = 771
Score = 324 bits (831), Expect = 2e-88
Identities = 215/636 (33%), Positives = 324/636 (50%), Gaps = 48/636 (7%)
Query: 68 SNYTALLLSRDGRTLYVGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKD 126
S+Y LL + LYVGA++ +F+ N+ ++Q+++W ++ +C + GKD
Sbjct: 55 SSYHTFLLDEERSRLYVGAKDHIFSFDLVNIK-----DFQKIVWPVSYTRRDECKWAGKD 109
Query: 127 PQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEK-GNVLLEDGKGRC 185
++C N+IK+L + +HL+ CGT AF P+CTYI + + K N E+G+G+
Sbjct: 110 ILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKS 169
Query: 186 PFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQS-LRPTKTES-SLNWLQDPAFVAS 243
P+DP + +L++DGELY+GT + F G D AI R+ P +TE WL DP F+++
Sbjct: 170 PYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISA 229
Query: 244 AYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSF 303
I ES +DDK+YFFF E + E +RI +ICK D GG R L +WT+F
Sbjct: 230 HLISESDNP---EDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTF 286
Query: 304 LKAQLLCSRPDDG---FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
LKA+L+CS P F+ LQDVF + + +D ++ + YGVFT+ +GSAVC+
Sbjct: 287 LKARLICSVPGPNGIDTHFDELQDVFLM--NFKDPKNPVVYGVFTTS--SNIFKGSAVCM 342
Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
++M DV+RVF G Y + QW VP PRPG C S +S+ LPD V+
Sbjct: 343 YSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTC--PSKTFGGFDSTKDLPDDVI 400
Query: 421 NFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLHK 475
F + H M V +R ++++ YQ ++ V RV YDV+F+GT G + K
Sbjct: 401 TFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLK 460
Query: 476 AVSVGPRVH------IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY 529
VS+ ++EE+ +F + + L T + LY S +GV Q+P+ C +Y
Sbjct: 461 VVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIY 520
Query: 530 -RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSF 588
++C +C LARDPYCAW GS+C S Y P R QDI CS +
Sbjct: 521 GKACAECCLARDPYCAWDGSAC---SRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHH- 576
Query: 589 VPTGEKPCEQVQF-QPNTVNTLACPLLSNLATRLW----LRNGAPVNASASCHVLPTGDL 643
G P E++ + N+ L C S A W H++ T
Sbjct: 577 ---GHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQG 633
Query: 644 LLVGTQQ---LGEFQCWSLEEGFQQLVASYCPEVVE 676
LL+ + Q G + C ++E GF Q + EV++
Sbjct: 634 LLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVID 669
>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
Length = 748
Score = 314 bits (804), Expect = 2e-85
Identities = 215/589 (36%), Positives = 303/589 (51%), Gaps = 47/589 (7%)
Query: 17 GALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEE--RPFLRFEAEHISNYTALL 74
GA P L LL + L P P PR+ L + F E Y ALL
Sbjct: 5 GAAAVIPGLALLWAVGLGSAAPSP-----PRLRLSFQELQAWHGLQTFSLERTCCYQALL 59
Query: 75 LSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQN 133
+ + L+VGA + +L+ N+S ++L W A E +++C++ GKD +C N
Sbjct: 60 VDEERGRLFVGAENHVASLNLDNIS----KRAKKLAWPAPVEWREECNWAGKDIGTECMN 115
Query: 134 YIKILLPLSGSHLFTCGTAAFSPMCTYINMENFT---LARDEKGNVLLEDGKGRCPFDPN 190
++K+L + +HL CGT AF P C ++ + + + R + G + EDGKG+ P+DP
Sbjct: 116 FVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRI--EDGKGKSPYDPR 173
Query: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTE-SSLNWLQDPAFVASAYIPE 248
++ +++V ELY+G + G D I RS RP+ +TE WL +P FV +IPE
Sbjct: 174 HRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPE 233
Query: 249 SLGSLQGDDDKIYFFFSETGQE-FEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQ 307
S DDDKIYFFF ET E VSR+ +IC+ D GG+R L +WT+FLKA+
Sbjct: 234 SENP---DDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKAR 290
Query: 308 LLCSRP--DDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365
L+CS P + F+ LQDVF L S +D R L Y VF++ +GSAVCV++M D
Sbjct: 291 LVCSVPGVEGDTHFDQLQDVFLL--SSRDHRTPLLYAVFSTS---SIFQGSAVCVYSMND 345
Query: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425
V+R F G + QW + VP PRPG C S +S+ PD V+ F ++
Sbjct: 346 VRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARN 403
Query: 426 HFLMDGQV---RSRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSV- 479
H LM V R L LQ A Y ++A RV YDVLF+GT G + K +SV
Sbjct: 404 HPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVP 463
Query: 480 -GPRVH----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCG 533
G R ++EEL +F V ++ + + R LY AS S V Q+ + C+ + R C
Sbjct: 464 KGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCT 523
Query: 534 DCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASS 582
+C LARDPYCAW G +C + +QP R QD+ LCS S
Sbjct: 524 ECCLARDPYCAWDGVAC---TRFQPSAKRRFRRQDVRNGDPSTLCSGDS 569
>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
Length = 749
Score = 314 bits (804), Expect = 2e-85
Identities = 215/589 (36%), Positives = 303/589 (51%), Gaps = 46/589 (7%)
Query: 17 GALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEE--RPFLRFEAEHISNYTALL 74
GA P L LL + L P P PR+ L + F E Y ALL
Sbjct: 5 GAAAVIPGLALLWAVGLGSAAPSP-----PRLRLSFQELQAWHGLQTFSLERTCCYQALL 59
Query: 75 LSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQN 133
+ + L+VGA + +L+ N+S ++L W A E +++C++ GKD +C N
Sbjct: 60 VDEERGRLFVGAENHVASLNLDNIS----KRAKKLAWPAPVEWREECNWAGKDIGTECMN 115
Query: 134 YIKILLPLSGSHLFTCGTAAFSPMCTYINMENFT---LARDEKGNVLLEDGKGRCPFDPN 190
++K+L + +HL CGT AF P C ++ + + + R + G + EDGKG+ P+DP
Sbjct: 116 FVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRI--EDGKGKSPYDPR 173
Query: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTE-SSLNWLQDPAFVASAYIPE 248
++ +++V ELY+G + G D I RS RP+ +TE WL +P FV +IPE
Sbjct: 174 HRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPE 233
Query: 249 SLGSLQGDDDKIYFFFSETGQE-FEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQ 307
S DDDKIYFFF ET E VSR+ +IC+ D GG+R L +WT+FLKA+
Sbjct: 234 SENP---DDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKAR 290
Query: 308 LLCSRP--DDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365
L+CS P + F+ LQDVF L S +D R L Y VF++ +GSAVCV++M D
Sbjct: 291 LVCSVPGVEGDTHFDQLQDVFLL--SSRDHRTPLLYAVFSTS--SSIFQGSAVCVYSMND 346
Query: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425
V+R F G + QW + VP PRPG C S +S+ PD V+ F ++
Sbjct: 347 VRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARN 404
Query: 426 HFLMDGQV---RSRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSV- 479
H LM V R L LQ A Y ++A RV YDVLF+GT G + K +SV
Sbjct: 405 HPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVP 464
Query: 480 -GPRVH----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCG 533
G R ++EEL +F V ++ + + R LY AS S V Q+ + C+ + R C
Sbjct: 465 KGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCT 524
Query: 534 DCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASS 582
+C LARDPYCAW G +C + +QP R QD+ LCS S
Sbjct: 525 ECCLARDPYCAWDGVAC---TRFQPSAKRRFRRQDVRNGDPSTLCSGDS 570
>gi|41406086 semaphorin 3D [Homo sapiens]
Length = 777
Score = 313 bits (803), Expect = 3e-85
Identities = 238/717 (33%), Positives = 353/717 (49%), Gaps = 67/717 (9%)
Query: 24 PLLLLLLLLLLLQPPPPTWALS-PRISLP-----LGSEERPFLRFEAEHISNYTALLLSR 77
P L++L + +L P T + PR+ L L + PFL +E + T LL
Sbjct: 20 PALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLG-SSEGLDFQTLLLDEE 78
Query: 78 DGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKI 137
GR L +GA++ +F LS L L ++++ W A E+ + C GKD +C N+I++
Sbjct: 79 RGRLL-LGAKDHIFLLS--LVDL-NKNFKKIYWPAAKERVELCKLAGKDANTECANFIRV 134
Query: 138 LLPLSGSHLFTCGTAAFSPMCTYINM----ENFTLARDEKGNVLLEDGKGRCPFDPNFKS 193
L P + +H++ CGT AF P+C YI++ E+ D LE G+ +CPFDP
Sbjct: 135 LQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHN---LESGRLKCPFDPQQPF 191
Query: 194 TALVVDGELYTGTVSSFQGNDPAISRSQSLRPT------KTESSLN-WLQDPAFVASAYI 246
+++ D LY+GT S F G D A +RS L PT +T+ S + WL F+ + +I
Sbjct: 192 ASVMTDEYLYSGTASDFLGKDTAFTRS--LGPTHDHHYIRTDISEHYWLNGAKFIGTFFI 249
Query: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKA 306
P++ DDDKIYFFF E+ QE + TI+SR+ R+CK D GG+R L +WT+FLKA
Sbjct: 250 PDTYNP---DDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKA 306
Query: 307 QLLCSRP-DDGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
+L+CS P DG F+ LQD++ L +D R+ + YGVFT+ +GSAVCV++M
Sbjct: 307 RLICSIPGSDGADTYFDELQDIYLL--PTRDERNPVVYGVFTTT--SSIFKGSAVCVYSM 362
Query: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
D++ VF+G Y +W +P PRPG C + + I S+ PD V++F+
Sbjct: 363 ADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTC-PSKTYDPLIKSTRDFPDDVISFI 421
Query: 424 KDHFLMDGQV-----RSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS 478
K H +M V + R ++ V V YDV+FLGT G + K VS
Sbjct: 422 KRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVS 481
Query: 479 VGPRVH-----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSC 532
+ ++EELQIF + N+ L + LY S G+VQ+ + C Y ++C
Sbjct: 482 ISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKAC 541
Query: 533 GDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTG 592
DC LARDPYCAW G++C S Y P R QD++ C S S
Sbjct: 542 ADCCLARDPYCAWDGNAC---SRYAPTSKRRARRQDVKYGDPITQC-WDIEDSISHETAD 597
Query: 593 EKPCEQVQFQPNTVNTLACPLLSNLATRLWL--RNGAP--VNASASCHVLPTGDLLLVGT 648
EK ++F L C S AT W R+G ++ T LL+ +
Sbjct: 598 EKVIFGIEFNS---TFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRS 654
Query: 649 QQ---LGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTD----EGGSVPVIISTSRV 698
Q G + C + E F + V+E+ + T E G V +++ SR+
Sbjct: 655 LQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEHEEGKVKDLLAESRL 711
>gi|9910362 semaphorin sem2 [Homo sapiens]
Length = 782
Score = 313 bits (803), Expect = 3e-85
Identities = 222/645 (34%), Positives = 320/645 (49%), Gaps = 50/645 (7%)
Query: 69 NYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQ 128
N A+ L L++G +AL++L + ++ + +E+LW ++++C KG+DP
Sbjct: 57 NLQAMYLDEYRDRLFLGGLDALYSLRLDQAW---PDPREVLWPPQPGQREECVRKGRDPL 113
Query: 129 RDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINM--ENFTLARDEKGNVLLEDGKGRCP 186
+C N++++L P + +HL CGT AF P C I + + E G+V E G+GRCP
Sbjct: 114 TECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSV--ESGRGRCP 171
Query: 187 FDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTESSLNWLQDPAFVASAY 245
+P+ + +DGELYTG + F G + I RS RP +++S + L DP FV +A
Sbjct: 172 HEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAAR 231
Query: 246 IPESLGSLQGDDDKIYFFFSETGQEFEFFENTI-VSRIARICKGDEGGERVLQQRWTSFL 304
IPE+ D+DK+YFFFSET + N + VSR+ R+C D GG+RVL +W++FL
Sbjct: 232 IPENSDQ---DNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFL 288
Query: 305 KAQLLCSRPDDG---FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVF 361
KA+L+CS P G F+ L+DVF L P+ + Y +F++ +G AVCV+
Sbjct: 289 KARLVCSVPGPGGAETHFDQLEDVFLL--WPKAGKSLEVYALFSTV--SAVFQGFAVCVY 344
Query: 362 TMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARE--RKINSSLQLPDRV 419
M D+ VF+G + + QW VP PRPG C + + R S+ PD V
Sbjct: 345 HMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEV 404
Query: 420 LNFLKDHFLMDGQVR---SRMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLH 474
L F + H LM VR R +L++ Q ++ V RV TYDV+FLGT G +
Sbjct: 405 LQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVL 464
Query: 475 KAV------SVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSL 528
K + S P ++EELQ+F P+ + + R +LY S GV Q+ + C
Sbjct: 465 KVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCET 524
Query: 529 Y-RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPW-IQDIEGASAKDLCSASSVVSP 586
Y +C +C LARDPYCAW G+SC H Y+P L R + QDI + C S
Sbjct: 525 YGTACAECCLARDPYCAWDGASCTH---YRPSLGKRRFRRQDIRHGNPALQCLGQSQEEE 581
Query: 587 SFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWL--RNG--APVNASASCHVLPTGD 642
+ G V + L C S A WL R G P VL T
Sbjct: 582 A---VGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTER 638
Query: 643 LLL---VGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTD 684
LL + G + C +LE GF Q V V+ VA Q D
Sbjct: 639 GLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVI---VASQLD 680
>gi|5454048 semaphorin 3C [Homo sapiens]
Length = 751
Score = 311 bits (798), Expect = 1e-84
Identities = 215/656 (32%), Positives = 328/656 (50%), Gaps = 64/656 (9%)
Query: 64 AEHISNYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSF 122
+ H +Y LL+ D +YVG+++ + +L+ +N+S E + W A K ++C
Sbjct: 48 SHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNIS----QEALSVFWPASTIKVEECKM 103
Query: 123 KGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYIN----MENFTLARDEKGNVLL 178
GKDP C N+++++ + +HL+ CG+ AFSP+CTY+N E+ D K
Sbjct: 104 AGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSK----C 159
Query: 179 EDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN--WLQ 236
E GKGRC F+PN + +++++ EL++G F G D AI RS + R N WL
Sbjct: 160 ESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLS 219
Query: 237 DPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVL 296
+P FV + IP+ +D K+YFFF E + I S IARIC D GG R L
Sbjct: 220 EPMFVDAHVIPD---GTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSL 276
Query: 297 QQRWTSFLKAQLLCSRPDDGFP---FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTT 353
+WT+FLKA+L+CS D+ P F+ L+DVF L + R TL YG+FT+
Sbjct: 277 VNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLL--ETDNPRTTLVYGIFTTS--SSVF 332
Query: 354 EGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSL 413
+GSAVCV+ + D+Q VF+G + Q + +P PRPG C A + ++
Sbjct: 333 KGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTC-PGGAFTPNMRTTK 391
Query: 414 QLPDRVLNFLKDHFLMDGQV-----RSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGT 468
+ PD V+ F+++H LM + R ++ + +Y ++AV RV Y VLFLGT
Sbjct: 392 EFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGT 451
Query: 469 GDGRLHKAV------SVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVP 522
G + K V SV + I+EEL++F + P+ + + + + LY +S+ GV QV
Sbjct: 452 DRGTVQKVVVLPTNNSVSGEL-ILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVS 510
Query: 523 MANCSLY-RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSAS 581
+ C +Y +C DC LARDPYCAW G SC S + P R QD+ + C
Sbjct: 511 LHRCHIYGTACADCCLARDPYCAWDGHSC---SRFYPTGKRRSRRQDVRHGNPLTQCRGF 567
Query: 582 SVVSPSFVPTGEKPCEQVQF-QPNTVNTLACPLLSNLATRLWL-------RNGAPVNASA 633
+ + E VQ+ N L C S A+ WL R +N
Sbjct: 568 N------LKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQKDKDRRKEVKLNE-- 619
Query: 634 SCHVLPTGDLLLVGTQQ---LGEFQCWSLEEGFQQLVASYCPEVVE-DGVADQTDE 685
++ T LL+ + Q G + C + E F+Q +A +V++ + VA TD+
Sbjct: 620 --RIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDK 673
>gi|188497703 semaphorin 3F [Homo sapiens]
Length = 785
Score = 294 bits (752), Expect = 3e-79
Identities = 209/657 (31%), Positives = 315/657 (47%), Gaps = 79/657 (12%)
Query: 68 SNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDP 127
++Y LL D +YVG+++ + LS +L + E + W A ++ ++C GKD
Sbjct: 55 TDYRILLKDEDHDRMYVGSKD--YVLSLDLHDI-NREPLIIHWAASPQRIEECVLSGKDV 111
Query: 128 QRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMEN------FTLARDEKGN------ 175
+C N+++++ P + +HL+ CGT A++PMCTY+N +T + +G
Sbjct: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
Query: 176 --------------------VLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDP 215
LE GKG+CP+DP + + +++ ELY G F G D
Sbjct: 172 GALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDA 231
Query: 216 AISRSQSLRPTKTESSLN--WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEF 273
AI R+ + N WL DP+F+ + IP+ S + +DDK+YFFF E E
Sbjct: 232 AIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPD---SAERNDDKLYFFFRERSAEAP- 287
Query: 274 FENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRP-DDGFP--FNVLQDVFTLSP 330
+ +RI RIC D+GG L +W++FLKA+L+CS P +DG F+ LQDVF
Sbjct: 288 QSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFV--Q 345
Query: 331 SPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHP 390
QD R+ + Y VFTS GSAVCV++M D++ VF+G + QW +
Sbjct: 346 QTQDVRNPVIYAVFTSS--GSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGK 403
Query: 391 VPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ 447
+P PRPG C + S+ PD V+NF++ H LM V + R L+++ A Y+
Sbjct: 404 MPYPRPGTC-PGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYR 462
Query: 448 --RVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVGPRVH------IIEELQIFSSGQPVQ 499
+AV +V Y+VLFLGT G + K + V P+ ++EE+++F PV+
Sbjct: 463 LTTIAVDQVDAADGRYEVLFLGTDRGTVQKVI-VLPKDDQELEELMLEEVEVFKDPAPVK 521
Query: 500 NLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCGDCLLARDPYCAWSGSSCKHVSLYQP 558
+ + + R LY AS GV + + C Y +C DC LARDPYCAW G +C S Y
Sbjct: 522 TMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQAC---SRYTA 578
Query: 559 QLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQF-QPNTVNTLACPLLSNL 617
R QD+ + C + + E VQ+ + L C S
Sbjct: 579 SSKRRSRRQDVRHGNPIRQCRGFN------SNANKNAVESVQYGVAGSAAFLECQPRSPQ 632
Query: 618 ATRLWLRNGAPVN----ASASCHVLPTGDLLLVGTQQL---GEFQCWSLEEGFQQLV 667
AT WL P + A L T LL+ QL G + C + E F+ +V
Sbjct: 633 ATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVV 689
>gi|6912650 semaphorin 3E [Homo sapiens]
Length = 775
Score = 290 bits (742), Expect = 4e-78
Identities = 212/676 (31%), Positives = 327/676 (48%), Gaps = 51/676 (7%)
Query: 73 LLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQ 132
+LL L+VG R+ +++LS L + G Y+E+ W + A K ++C KGKD +C
Sbjct: 61 MLLDEYQERLFVGGRDLVYSLS--LERISDG-YKEIHWPSTALKMEECIMKGKDAG-ECA 116
Query: 133 NYIKILLPLSGSHLFTCGTAAFSPMCTYI----NMENFTLARDEKGNVLLEDGKGRCPFD 188
NY+++L + +HL TCGT AF P+C +I ++E+ + + E G+GRCPFD
Sbjct: 117 NYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRS---ERGRGRCPFD 173
Query: 189 PNFKSTALVVDGELYTGTVSSFQGNDPAISRSQS-LRPTKTE-SSLNWLQDPAFVASAYI 246
P+ + ++ EL+ G S + D AI RS L +TE L++P FV S I
Sbjct: 174 PSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMI 233
Query: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKA 306
P++ DD+K+YFFF+E E E + I +R+ R+C D GG+R+L +W++FLKA
Sbjct: 234 PDNEDR---DDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKA 290
Query: 307 QLLCSRPD-DGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
+L+CS P +G F+ L+DVF L +D ++ + +G+F + G A+CV+ M
Sbjct: 291 RLVCSVPGMNGIDTYFDELEDVFLL--PTRDHKNPVIFGLFNTT--SNIFRGHAICVYHM 346
Query: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
++ F+G Y W VP PRPG+C + + ++ PD + F
Sbjct: 347 SSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSC-ASKVNGGRYGTTKDYPDDAIRFA 405
Query: 424 KDHFLMDGQVR---SRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS 478
+ H LM ++ + +L++ +Y +++AV RV YDVLF+GT +G + K ++
Sbjct: 406 RSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVIT 465
Query: 479 V------GPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRS- 531
+ I+EELQIF P+ ++ + + R LY S S V QV +C +Y S
Sbjct: 466 IYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSA 525
Query: 532 CGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPT 591
C DC LARDPYCAW G SC R QD+ +A C V + T
Sbjct: 526 CADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKT 585
Query: 592 GEKPCEQVQFQPNTVNTLACPLLSNLATRLWL------RNGAPVNASASCHVLPTGDLLL 645
E ++ N L C S A +W V + G L L
Sbjct: 586 EEHLAYGIE---NNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFL 642
Query: 646 -VGTQQLGEFQCWSLEEGFQQLVASYCPEVV-EDGVADQTDEGGSVPVIISTSRVSAPAG 703
+ G + C ++E F V EVV E+ V D ++ R+ PA
Sbjct: 643 RLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEED---RHHRMPCPAQ 699
Query: 704 GKASWGADRSYWKEFL 719
S GA + ++KEFL
Sbjct: 700 SSISQGA-KPWYKEFL 714
>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
Length = 1073
Score = 265 bits (676), Expect = 2e-70
Identities = 187/586 (31%), Positives = 292/586 (49%), Gaps = 74/586 (12%)
Query: 63 EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
E++H ++ +L RD TLY+ R+ ++ + NL+ +P E ++L W + + ++
Sbjct: 52 ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107
Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
C+ KGK +C N+IK+ +P + +F CGT AF+PMC Y + +E
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161
Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
G RCPFD + AL DG+LY+ TV+ F +D I RS +LR K +S W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218
Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
++P F+ + + +YFFF E E + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268
Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
VL++ WTSFLKA+L CS P D F F+VLQ D+ ++ P GVFT+Q +
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321
Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
+ GSAVC F+M D+++VF G +KE W V VP PRPG C + E
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379
Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
+S+ PD L+F+K H LMD V + + RY+ ++V G + Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439
Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
F+G+ G + K + S+ V ++EE++ ++ + V +L LD
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498
Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVSLYQPQLATRPWIQ 567
LY A S ++++P++ C Y SC C+ +RDPYC W S SC V+ P + + Q
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT---PGMLAEGYEQ 555
Query: 568 DIEGASAKDLCSASSVVSPSFVPTGE---KPCEQVQFQPNTVNTLA 610
D E + L ++ S P + P ++ ++V T+A
Sbjct: 556 DTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMA 601
>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
Length = 1017
Score = 263 bits (671), Expect = 7e-70
Identities = 183/563 (32%), Positives = 282/563 (50%), Gaps = 71/563 (12%)
Query: 63 EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
E++H ++ +L RD TLY+ R+ ++ + NL+ +P E ++L W + + ++
Sbjct: 52 ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107
Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
C+ KGK +C N+IK+ +P + +F CGT AF+PMC Y + +E
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161
Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
G RCPFD + AL DG+LY+ TV+ F +D I RS +LR K +S W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218
Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
++P F+ + + +YFFF E E + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268
Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
VL++ WTSFLKA+L CS P D F F+VLQ D+ ++ P GVFT+Q +
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321
Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
+ GSAVC F+M D+++VF G +KE W V VP PRPG C + E
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379
Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
+S+ PD L+F+K H LMD V + + RY+ ++V G + Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439
Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
F+G+ G + K + S+ V ++EE++ ++ + V +L LD
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498
Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVSLYQPQLATRPWIQ 567
LY A S ++++P++ C Y SC C+ +RDPYC W S SC V+ P + + Q
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT---PGMLAEGYEQ 555
Query: 568 DIEGASAKDLCSASSVVSPSFVP 590
D E + L ++ S P
Sbjct: 556 DTEFGNTAHLGDCHEILPTSTTP 578
>gi|19718780 semaphorin 6B precursor [Homo sapiens]
Length = 888
Score = 263 bits (671), Expect = 7e-70
Identities = 213/614 (34%), Positives = 298/614 (48%), Gaps = 78/614 (12%)
Query: 18 ALPPRPPLLLLLLLL-----LLLQPPPPTWALSPRISL---PLGSEERPFLRFEAEHISN 69
A PPRP LLLLLLLL L + PPP +++PR L P+ P AE +
Sbjct: 6 ASPPRPALLLLLLLLGGAHGLFPEEPPPL-SVAPRDYLNHYPVFVGSGPGRLTPAEGADD 64
Query: 70 YTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQ-ELLWGADAEKKQQCSFKGKDPQ 128
+ R RTL++G R+ L+ + YQ +L W ++ C KGK +
Sbjct: 65 LNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQ-E 123
Query: 129 RDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFD 188
+C+N++K+LL S LF CG+ AF+P+C +++ D N+ G RCP+D
Sbjct: 124 GECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQPVGD---NI---SGMARCPYD 177
Query: 189 PNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT--KTESSLNWLQDPAFVASAYI 246
P + AL DG L+T TV+ F D I RS RPT + W ++P FV +
Sbjct: 178 PKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAV-- 235
Query: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGE-RVLQQRWTSFLK 305
GS +YFFF E EF + E +VSR+AR+CK D GG RVL+++WTSFLK
Sbjct: 236 --EWGS------HVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLK 287
Query: 306 AQLLCSRPDDG-FPFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVF 361
A+L CS P D F FNVLQ V +L P + VF++ + GSAVC F
Sbjct: 288 ARLNCSVPGDSHFYFNVLQAVTGVVSLGGRP------VVLAVFSTP--SNSIPGSAVCAF 339
Query: 362 TMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKINSSLQLPDRVL 420
+ V VF G ++E W V VP PRPG C +A + N+S LPD +L
Sbjct: 340 DLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCC---AAPGMQYNASSALPDDIL 396
Query: 421 NFLKDHFLMDGQVRS---RMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLHK 475
NF+K H LMD V S +L+ R+Q RVAV G V+FLG+ G + K
Sbjct: 397 NFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLK 456
Query: 476 AVSVGPRVH---------IIEELQIF-----------SSGQPVQNLLLDTHRGLLYAASH 515
+ V P +EE + + +GQ + +L LD G L AA
Sbjct: 457 FL-VRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFP 515
Query: 516 SGVVQVPMANCSLYRSC-GDCLLARDPYCAWS-GSSCKHVSLYQPQLATRPWIQDIEGAS 573
VV+VP+A C Y C +C+ ++DPYC W+ SC ++ + QD+ GAS
Sbjct: 516 RCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSC----IFLSPGTRAAFEQDVSGAS 571
Query: 574 AKDLCSASSVVSPS 587
L + ++ S
Sbjct: 572 TSGLGDCTGLLRAS 585
>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
Length = 597
Score = 261 bits (666), Expect = 2e-69
Identities = 186/565 (32%), Positives = 284/565 (50%), Gaps = 72/565 (12%)
Query: 63 EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
E++H ++ +L RD TLY+ R+ ++ + NL+ +P E ++L W + + ++
Sbjct: 52 ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107
Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
C+ KGK +C N+IK+ +P + +F CGT AF+PMC Y + +E
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161
Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
G RCPFD + AL DG+LY+ TV+ F +D I RS +LR K +S W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218
Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
++P F+ + + +YFFF E E + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268
Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
VL++ WTSFLKA+L CS P D F F+VLQ D+ ++ P GVFT+Q +
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321
Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
+ GSAVC F+M D+++VF G +KE W V VP PRPG C + E
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379
Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
+S+ PD L+F+K H LMD V + + RY+ ++V G + Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439
Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
F+G+ G + K + S+ V ++EE++ ++ + V +L LD
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498
Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVSLYQPQLATRPWIQ 567
LY A S ++++P++ C Y SC C+ +RDPYC W S SC V+ P + + Q
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT---PGMLAEGYEQ 555
Query: 568 DIEGASAKDLCSASSV-VSPSFVPT 591
D E + L + VS S V T
Sbjct: 556 DTEFGNTAHLGDCHDMEVSSSSVTT 580
>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
Length = 998
Score = 260 bits (664), Expect = 4e-69
Identities = 180/543 (33%), Positives = 276/543 (50%), Gaps = 71/543 (13%)
Query: 63 EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
E++H ++ +L RD TLY+ R+ ++ + NL+ +P E ++L W + + ++
Sbjct: 52 ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107
Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
C+ KGK +C N+IK+ +P + +F CGT AF+PMC Y + +E
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161
Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
G RCPFD + AL DG+LY+ TV+ F +D I RS +LR K +S W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218
Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
++P F+ + + +YFFF E E + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268
Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
VL++ WTSFLKA+L CS P D F F+VLQ D+ ++ P GVFT+Q +
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321
Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
+ GSAVC F+M D+++VF G +KE W V VP PRPG C + E
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379
Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
+S+ PD L+F+K H LMD V + + RY+ ++V G + Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439
Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
F+G+ G + K + S+ V ++EE++ ++ + V +L LD
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498
Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVSLYQPQLATRPWIQ 567
LY A S ++++P++ C Y SC C+ +RDPYC W S SC V+ P + + Q
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT---PGMLAEGYEQ 555
Query: 568 DIE 570
D E
Sbjct: 556 DTE 558
>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
Length = 1011
Score = 258 bits (660), Expect = 1e-68
Identities = 176/527 (33%), Positives = 270/527 (51%), Gaps = 68/527 (12%)
Query: 63 EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
E++H ++ +L RD TLY+ R+ ++ + NL+ +P E ++L W + + ++
Sbjct: 52 ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107
Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
C+ KGK +C N+IK+ +P + +F CGT AF+PMC Y + +E
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161
Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
G RCPFD + AL DG+LY+ TV+ F +D I RS +LR K +S W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218
Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
++P F+ + + +YFFF E E + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268
Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
VL++ WTSFLKA+L CS P D F F+VLQ D+ ++ P GVFT+Q +
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321
Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
+ GSAVC F+M D+++VF G +KE W V VP PRPG C + E
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379
Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
+S+ PD L+F+K H LMD V + + RY+ ++V G + Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439
Query: 465 FLGTGDGRLHKAV------SVGPRVHIIEELQIFS---------SGQPVQNLLLDTHRGL 509
F+G+ G + K + S+ V ++EE++ ++ + V +L LD
Sbjct: 440 FVGSEAGMVLKVLAKTSPFSLNDSV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHA 498
Query: 510 LYAASHSGVVQVPMANCSLYRSC-GDCLLARDPYCAW-SGSSCKHVS 554
LY A S ++++P++ C Y SC C+ +RDPYC W S SC V+
Sbjct: 499 LYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVT 545
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 253 bits (647), Expect = 4e-67
Identities = 176/522 (33%), Positives = 257/522 (49%), Gaps = 53/522 (10%)
Query: 69 NYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDP 127
+++ L L G L VGAR LF LS +N+S L E W + + ++ C KGK
Sbjct: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATE-----WASSEDTRRSCQSKGKT- 178
Query: 128 QRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPF 187
+ +CQNY+++L+ ++G +F CGT AFSPMCT + N + ++ +G RCP+
Sbjct: 179 EEECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKI------NGVARCPY 231
Query: 188 DPNFKSTALVVD-GELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN--WLQDPAFVASA 244
DP STA++ GELY TV F G DPAI RS P + N WL +P FVA A
Sbjct: 232 DPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVA-A 290
Query: 245 YIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFL 304
Y +G YFF E E + T+ SR+AR+CK D GG +L+ WT+F+
Sbjct: 291 Y---DIGLFA------YFFLRENAVEHDC-GRTVYSRVARVCKNDVGGRFLLEDTWTTFM 340
Query: 305 KAQLLCSRPDD-GFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
KA+L CSRP + F +N LQ F L L YGVFT+ + + SAVC F +
Sbjct: 341 KARLNCSRPGEVPFYYNELQSAFHLP------EQDLIYGVFTT--NVNSIAASAVCAFNL 392
Query: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
+ + F+G ++ W + +P+P + G E SLQ R+
Sbjct: 393 SAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRL---- 448
Query: 424 KDHFLMDGQVR---SRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480
FLM V+ + Q R+ + V V Y VL++GT G + KA+S
Sbjct: 449 ---FLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTA 505
Query: 481 PR-VH--IIEELQIFSSG--QPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDC 535
R +H +EEL + G +P+++L + L+ GV++VP+ C+ YRS G C
Sbjct: 506 SRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGAC 565
Query: 536 LLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDL 577
L ARDPYC W G + S + W Q+I +++
Sbjct: 566 LGARDPYCGWDGKQ-QRCSTLEDSSNMSLWTQNITACPVRNV 606
>gi|16306552 semaphorin Y [Homo sapiens]
Length = 930
Score = 246 bits (627), Expect = 8e-65
Identities = 194/570 (34%), Positives = 277/570 (48%), Gaps = 71/570 (12%)
Query: 21 PRPPLLLLLLLLLLLQPPPPTWALSPRISLPL------GSEERPFLR-FEAEHISNYTAL 73
PR P + LLLLLLL P T A P+ LPL G+ + R E + ++ L
Sbjct: 2 PRAPHFMPLLLLLLLLSLPHTQAAFPQDPLPLLISDLQGTSPLSWFRGLEDDAVAAELGL 61
Query: 74 LLSRD---GRTLYVGAREALFALSSNLSFLPGGE----YQELLWGADAEKKQQCSFKGKD 126
R RTL V AR+ +F S +L GE + L W + + + C+ +GK
Sbjct: 62 DFQRFLTLNRTLLVAARDHVF--SFDLQAEEEGEGLVPNKYLTWRS--QDVENCAVRGKL 117
Query: 127 PQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCP 186
+C NYI++L+P L CGT +FSP+C + + ++G L G+ RCP
Sbjct: 118 TD-ECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSL----QQEGEEL--SGQARCP 170
Query: 187 FDPNFKSTALVVDGELYTGTVSSFQGNDPAISRS----QSLRPTKTESSLNWLQDPAFVA 242
FD + A+ +G LY+ T + FQ +D + RS LR K +S WL++P FV
Sbjct: 171 FDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDS--KWLREPHFVQ 228
Query: 243 SAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGE-RVLQQRWT 301
+ D +YFFF E E SR+AR+CK D GG R L + WT
Sbjct: 229 AL----------EHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWT 278
Query: 302 SFLKAQLLCSRPDDG-FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
SFLK +L CS P D F F+VLQ + P R LF GVFT+Q + GSAVC
Sbjct: 279 SFLKLRLNCSVPGDSTFYFDVLQAL--TGPVNLHGRSALF-GVFTTQ--TNSIPGSAVCA 333
Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHP-VPTPRPGACITNSARERKINSSLQLPDRV 419
F + +++R F G +KE W V+ VP+PRPG+C +SS LPD V
Sbjct: 334 FYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSC-AGVGGAALFSSSRDLPDDV 392
Query: 420 LNFLKDHFLMDGQV----RSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHK 475
L F+K H L+D V +L L +A +VAV + G H V+FLG+ DG + K
Sbjct: 393 LTFIKAHPLLDPAVPPVTHQPLLTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLK 452
Query: 476 AV-----SVGPRVHIIEELQIFS-----------SGQPVQNLLLDTHRGLLYAASHSGVV 519
+ S GP ++EE+ +S + + + L LDT L+ A +V
Sbjct: 453 VLTPGGRSGGPEPILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIV 512
Query: 520 QVPMANCSLYRSC-GDCLLARDPYCAWSGS 548
+P++ C+ + +C CL ++DPYC W S
Sbjct: 513 YLPLSRCARHGACQRSCLASQDPYCGWHSS 542
>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
domain, (semaphorin) 6A [Homo sapiens]
Length = 1030
Score = 243 bits (621), Expect = 4e-64
Identities = 170/506 (33%), Positives = 252/506 (49%), Gaps = 58/506 (11%)
Query: 81 TLYVGAREALFALSSNLSFLPGGEY-QELLWGADAEKKQQCSFKGKDPQRDCQNYIKILL 139
TLY+ AR+ ++ + + S ++L W + C KGK +C N+IK+LL
Sbjct: 67 TLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKVLL 125
Query: 140 PLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVD 199
+ LF CGT AF+P C M+ DE G RCP+D + AL D
Sbjct: 126 KKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFS------GMARCPYDAKHANVALFAD 179
Query: 200 GELYTGTVSSFQGNDPAISRSQSLRPT--KTESSLNWLQDPAFVASAYIPESLGSLQGDD 257
G+LY+ TV+ F D I RS PT + WL++P FV +
Sbjct: 180 GKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAV----------DYG 229
Query: 258 DKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ERVLQQRWTSFLKAQLLCSRPDDG 316
D IYFFF E E+ + R+A++CK D GG +RVL+++WTSFLKA+L CS P D
Sbjct: 230 DYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDS 289
Query: 317 -FPFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSG 372
F FN+LQ DV + + RD + F++ ++ + GSAVC + M D+ VF+G
Sbjct: 290 HFYFNILQAVTDVIRI-----NGRDVVL-ATFSTPYN--SIPGSAVCAYDMLDIASVFTG 341
Query: 373 LYKEVNRETQQWYTV-THPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDG 431
+KE W V VP PRPG C +S+ ER S+ + PD LNF+K H LMD
Sbjct: 342 RFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSN-EFPDDTLNFIKTHPLMDE 400
Query: 432 QVRS---RMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS-VGPRVHI 485
V S R L+ RY+ ++AV G + + V+FLG+ G + K ++ +G +
Sbjct: 401 AVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFL 460
Query: 486 -----IEELQIFSS---------GQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRS 531
+EE+ +++S + + + LD LY A + V++VP+ C +
Sbjct: 461 NDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGK 520
Query: 532 C-GDCLLARDPYCAW--SGSSCKHVS 554
C C+ +RDPYC W G +C H+S
Sbjct: 521 CKKTCIASRDPYCGWIKEGGACSHLS 546
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 240 bits (612), Expect = 5e-63
Identities = 171/531 (32%), Positives = 259/531 (48%), Gaps = 49/531 (9%)
Query: 58 PFLR-FEAEHISNYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAE 115
P+LR F A++ +++ L + L VGAR LF L +LS + Q + W D
Sbjct: 45 PWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLI-----QAVEWECDEA 99
Query: 116 KKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGN 175
K+ C KGK + +CQNYI++LL + G LFTCGT AF+P+CT ++ N T D+
Sbjct: 100 TKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQIS- 156
Query: 176 VLLEDGKGRCPFDPNFKSTALVV-DGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN- 233
G RCP+ P STAL+ GELY T F G DPAI RS + P + N
Sbjct: 157 -----GMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNS 211
Query: 234 -WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG 292
WL +P FV+S I + YFFF E E + + T+ SR AR+CK D GG
Sbjct: 212 KWLNEPNFVSSYDI----------GNFTYFFFRENAVEHDCGK-TVFSRAARVCKNDIGG 260
Query: 293 ERVLQQRWTSFLKAQLLCSRPDD-GFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRG 351
+L+ WT+F+KA+L CSRP + F +N LQ F L L YG+FT+ +
Sbjct: 261 RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL------DLIYGIFTT--NVN 312
Query: 352 TTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINS 411
+ SAVCVF + + + FSG +K W P P P P + +N
Sbjct: 313 SIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWL----PYPNPNPHFQCGTVDQGLYVNL 368
Query: 412 SLQLPDRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDG 471
+ + F+ H ++ V + ++ +R+ VAV V G +++L T G
Sbjct: 369 TERNLQDAQKFILMHEVVQ-PVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYG 427
Query: 472 RLHKA---VSVGPRVHIIEELQIFSS--GQPVQNLLLDTHRGLLYAASHSGVVQVPMANC 526
+ K ++ ++EE+++F +P+++L + + +L+ VV++P+ C
Sbjct: 428 TIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
Query: 527 SLYRSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDL 577
YR+ C+ A+DPYC W K SL + L+ W Q I ++L
Sbjct: 488 QFYRTRSTCIGAQDPYCGWDVVMKKCTSL-EESLSMTQWEQSISACPTRNL 537
>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
Length = 666
Score = 233 bits (594), Expect = 6e-61
Identities = 211/694 (30%), Positives = 302/694 (43%), Gaps = 97/694 (13%)
Query: 13 AAPWGALPPRP-----PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL------- 60
+AP +P P PL L LLLLL WA + L S R F
Sbjct: 12 SAPRARVPGPPARLGLPLRLRLLLLL--------WAAAASAQGHLRSGPRIFAVWKGHVG 63
Query: 61 --RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQ 118
R + +T L +++VG R ++ P G+ + K
Sbjct: 64 QDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFD-----FPEGKNASVRTVNIGSTKG 118
Query: 119 QCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLL 178
C K RDC+NYI LL L CGT A P C N+ N T+ V L
Sbjct: 119 SCLDK-----RDCENYIT-LLERRSEGLLACGTNARHPSCW--NLVNGTV-------VPL 163
Query: 179 EDGKGRCPFDPNFKSTALVVDGELY-TGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQD 237
+ +G PF P+ S L E+Y T + G P R + T ++ +Q+
Sbjct: 164 GEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQN 221
Query: 238 PAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQ 297
P F+ + + + Q DDKIY+FF E + VSR+A++C+GD+GGE L
Sbjct: 222 PQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLS 277
Query: 298 -QRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGS 356
+W +FLKA L+CS FN LQDVF L WRDT YGVF++ W+ S
Sbjct: 278 VSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----S 332
Query: 357 AVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLP 416
AVCV+++ D+ +VF T +P PRPG C+ + ++ + Q+
Sbjct: 333 AVCVYSLGDIDKVF---------RTSSLKGYHSSLPNPRPGKCLPD--QQPIPTETFQVA 381
Query: 417 DRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHK 475
DR + ++ + L + YQ+VAVHR+ H T+ VL+L T G +HK
Sbjct: 382 DRHPEVAQ---RVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHK 438
Query: 476 AVSVGPRVHI----IEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-R 530
V G + H I E+Q F +Q + LD R LY +S V QVP+ C +Y
Sbjct: 439 VVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGG 498
Query: 531 SCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVP 590
C CL++RDPYC W C +S+Y + R +Q I A C P+ P
Sbjct: 499 GCHGCLMSRDPYCGWDQGRC--ISIYSSE---RSVLQSINPAEPHKEC-------PNPKP 546
Query: 591 TGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASC---HVLPTGDLLL-- 645
+ P ++V PN+ L+CP+ S AT W N SC H P L +
Sbjct: 547 -DKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHK---ENVEQSCEPGHQSPNCILFIEN 602
Query: 646 VGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGV 679
+ QQ G + C +EG A + + EDG+
Sbjct: 603 LTAQQYGHYFC-EAQEGSYFREAQHWQLLPEDGI 635
>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
Length = 652
Score = 228 bits (581), Expect = 2e-59
Identities = 182/570 (31%), Positives = 262/570 (45%), Gaps = 65/570 (11%)
Query: 123 KGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGK 182
K + DC+NYI LL L CGT A P C N+ N T+ V L + +
Sbjct: 104 KNASVRTDCENYIT-LLERRSEGLLACGTNARHPSCW--NLVNGTV-------VPLGEMR 153
Query: 183 GRCPFDPNFKSTALVVDGELY-TGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFV 241
G PF P+ S L E+Y T + G P R + T ++ +Q+P F+
Sbjct: 154 GYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQNPQFI 211
Query: 242 ASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQ-QRW 300
+ + + Q DDKIY+FF E + VSR+A++C+GD+GGE L +W
Sbjct: 212 KATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKW 267
Query: 301 TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
+FLKA L+CS FN LQDVF L WRDT YGVF++ W+ SAVCV
Sbjct: 268 NTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----SAVCV 322
Query: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
+++ D+ +VF T +P PRPG C+ + ++ + Q+ DR
Sbjct: 323 YSLGDIDKVF---------RTSSLKGYHSSLPNPRPGKCLPD--QQPIPTETFQVADRHP 371
Query: 421 NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSV 479
+ ++ + L + YQ+VAVHR+ H T+ VL+L T G +HK V
Sbjct: 372 EVAQ---RVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEP 428
Query: 480 GPRVHI----IEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCGD 534
G + H I E+Q F +Q + LD R LY +S V QVP+ C +Y C
Sbjct: 429 GEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHG 488
Query: 535 CLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEK 594
CL++RDPYC W C +S+Y + R +Q I A C P+ P +
Sbjct: 489 CLMSRDPYCGWDQGRC--ISIYSSE---RSVLQSINPAEPHKEC-------PNPKP-DKA 535
Query: 595 PCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASC---HVLPTGDLLL--VGTQ 649
P ++V PN+ L+CP+ S AT W N SC H P L + + Q
Sbjct: 536 PLQKVSLAPNSRYYLSCPMESRHATYSWRHK---ENVEQSCEPGHQSPNCILFIENLTAQ 592
Query: 650 QLGEFQCWSLEEGFQQLVASYCPEVVEDGV 679
Q G + C +EG A + + EDG+
Sbjct: 593 QYGHYFC-EAQEGSYFREAQHWQLLPEDGI 621
>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
Length = 476
Score = 223 bits (568), Expect = 6e-58
Identities = 148/434 (34%), Positives = 225/434 (51%), Gaps = 50/434 (11%)
Query: 63 EAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEY---QELLWGADAEKKQQ 119
E++H ++ +L RD TLY+ R+ ++ + NL+ +P E ++L W + + ++
Sbjct: 52 ESQHRLDFQLMLKIRD--TLYIAGRDQVYTV--NLNEMPKTEVIPNKKLTWRSRQQDREN 107
Query: 120 CSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLE 179
C+ KGK +C N+IK+ +P + +F CGT AF+PMC Y + +E
Sbjct: 108 CAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEIS----- 161
Query: 180 DGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ----SLRPTKTESSLNWL 235
G RCPFD + AL DG+LY+ TV+ F +D I RS +LR K +S W+
Sbjct: 162 -GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSK--WI 218
Query: 236 QDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG-ER 294
++P F+ + + +YFFF E E + SR+ARICK D GG +R
Sbjct: 219 KEPHFLHAIEY----------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQR 268
Query: 295 VLQQRWTSFLKAQLLCSRPDDGF-PFNVLQ---DVFTLSPSPQDWRDTLFYGVFTSQWHR 350
VL++ WTSFLKA+L CS P D F F+VLQ D+ ++ P GVFT+Q +
Sbjct: 269 VLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPT------VVGVFTTQLN- 321
Query: 351 GTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNSARERKI 409
+ GSAVC F+M D+++VF G +KE W V VP PRPG C + E
Sbjct: 322 -SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAE-AY 379
Query: 410 NSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVL 464
+S+ PD L+F+K H LMD V + + RY+ ++V G + Y V+
Sbjct: 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439
Query: 465 FLGTGDGRLHKAVS 478
F+G+ G + K ++
Sbjct: 440 FVGSEAGMVLKVLA 453
>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
Length = 501
Score = 210 bits (535), Expect = 4e-54
Identities = 162/511 (31%), Positives = 237/511 (46%), Gaps = 55/511 (10%)
Query: 182 KGRCPFDPNFKSTALVVDGELY-TGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF 240
+G PF P+ S L E+Y T + G P R + T ++ +Q+P F
Sbjct: 2 RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQNPQF 59
Query: 241 VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQ-QR 299
+ + + + Q DDKIY+FF E + VSR+A++C+GD+GGE L +
Sbjct: 60 IKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSK 115
Query: 300 WTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVC 359
W +FLKA L+CS FN LQDVF L WRDT YGVF++ W+ SAVC
Sbjct: 116 WNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----SAVC 170
Query: 360 VFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRV 419
V+++ D+ +VF T +P PRPG C+ + ++ + Q+ DR
Sbjct: 171 VYSLGDIDKVF---------RTSSLKGYHSSLPNPRPGKCLPD--QQPIPTETFQVADRH 219
Query: 420 LNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVS 478
+ ++ + L + YQ+VAVHR+ H T+ VL+L T G +HK V
Sbjct: 220 PEVAQ---RVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE 276
Query: 479 VGPRVHI----IEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCG 533
G + H I E+Q F +Q + LD R LY +S V QVP+ C +Y C
Sbjct: 277 PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCH 336
Query: 534 DCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGE 593
CL++RDPYC W C +S+Y + R +Q I A C P+ P +
Sbjct: 337 GCLMSRDPYCGWDQGRC--ISIYSSE---RSVLQSINPAEPHKEC-------PNPKP-DK 383
Query: 594 KPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASC---HVLPTGDLLL--VGT 648
P ++V PN+ L+CP+ S AT W N SC H P L + +
Sbjct: 384 APLQKVSLAPNSRYYLSCPMESRHATYSWRHK---ENVEQSCEPGHQSPNCILFIENLTA 440
Query: 649 QQLGEFQCWSLEEGFQQLVASYCPEVVEDGV 679
QQ G + C +EG A + + EDG+
Sbjct: 441 QQYGHYFC-EAQEGSYFREAQHWQLLPEDGI 470
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,056,066
Number of Sequences: 37866
Number of extensions: 1911176
Number of successful extensions: 5977
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 5518
Number of HSP's gapped (non-prelim): 179
length of query: 837
length of database: 18,247,518
effective HSP length: 111
effective length of query: 726
effective length of database: 14,044,392
effective search space: 10196228592
effective search space used: 10196228592
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.