Guide to the Human Genome
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Search of human proteins with 39752683

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39752683 prestin isoform a [Homo sapiens]
         (744 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39752683 prestin isoform a [Homo sapiens]                         1462   0.0  
gi|45827800 prestin isoform b [Homo sapiens]                         1337   0.0  
gi|45827802 prestin isoform c [Homo sapiens]                          987   0.0  
gi|45827804 prestin isoform d [Homo sapiens]                          642   0.0  
gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo s...   564   e-161
gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo s...   560   e-159
gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo s...   559   e-159
gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo s...   558   e-159
gi|4505697 pendrin [Homo sapiens]                                     538   e-153
gi|4557535 solute carrier family 26, member 3 [Homo sapiens]          513   e-145
gi|16418413 solute carrier family 26, member 9 isoform a [Homo s...   492   e-139
gi|217272867 solute carrier family 26, member 9 isoform b [Homo ...   492   e-139
gi|100913030 solute carrier family 26 member 2 [Homo sapiens]         461   e-130
gi|47131207 solute carrier family 26, member 1 isoform a [Homo s...   414   e-115
gi|20336272 solute carrier family 26, member 1 isoform a [Homo s...   414   e-115
gi|16306483 solute carrier family 26, member 7 isoform a [Homo s...   300   2e-81
gi|20336282 solute carrier family 26, member 7 isoform b [Homo s...   300   2e-81
gi|16418457 solute carrier family 26, member 8 isoform a [Homo s...   282   7e-76
gi|65506789 solute carrier family 26, member 10 [Homo sapiens]        258   1e-68
gi|217272870 solute carrier family 26, member 9 isoform c [Homo ...   256   4e-68
gi|85540447 solute carrier family 26, member 11 [Homo sapiens]        186   5e-47
gi|20336285 solute carrier family 26, member 8 isoform b [Homo s...   171   3e-42
gi|20336274 solute carrier family 26, member 1 isoform b [Homo s...   109   8e-24
gi|32401433 G protein-coupled receptor 142 [Homo sapiens]              31   4.8  
gi|18379366 zinc metallopeptidase STE24 [Homo sapiens]                 30   8.1  
gi|45827778 reticulon 1 isoform B [Homo sapiens]                       30   8.1  
gi|45827776 reticulon 1 isoform C [Homo sapiens]                       30   8.1  
gi|10863935 reticulon 1 isoform A [Homo sapiens]                       30   8.1  

>gi|39752683 prestin isoform a [Homo sapiens]
          Length = 744

 Score = 1462 bits (3784), Expect = 0.0
 Identities = 744/744 (100%), Positives = 744/744 (100%)

Query: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60
           MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
Sbjct: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60

Query: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120
           IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
Sbjct: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120

Query: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180
           IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
Sbjct: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180

Query: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240
           SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
Sbjct: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240

Query: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300
           FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
Sbjct: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300

Query: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360
           TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
Sbjct: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360

Query: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420
           LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
Sbjct: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420

Query: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480
           ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
Sbjct: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480

Query: 481 FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI 540
           FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI
Sbjct: 481 FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI 540

Query: 541 NAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVD 600
           NAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVD
Sbjct: 541 NAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVD 600

Query: 601 GEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTL 660
           GEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTL
Sbjct: 601 GEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTL 660

Query: 661 AGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLREALA 720
           AGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLREALA
Sbjct: 661 AGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLREALA 720

Query: 721 EQEASAPPSQEDLEPNATPATPEA 744
           EQEASAPPSQEDLEPNATPATPEA
Sbjct: 721 EQEASAPPSQEDLEPNATPATPEA 744


>gi|45827800 prestin isoform b [Homo sapiens]
          Length = 685

 Score = 1337 bits (3459), Expect = 0.0
 Identities = 681/681 (100%), Positives = 681/681 (100%)

Query: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60
           MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
Sbjct: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60

Query: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120
           IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
Sbjct: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120

Query: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180
           IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
Sbjct: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180

Query: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240
           SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
Sbjct: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240

Query: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300
           FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
Sbjct: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300

Query: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360
           TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
Sbjct: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360

Query: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420
           LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
Sbjct: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420

Query: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480
           ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
Sbjct: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480

Query: 481 FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI 540
           FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI
Sbjct: 481 FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI 540

Query: 541 NAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVD 600
           NAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVD
Sbjct: 541 NAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVD 600

Query: 601 GEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTL 660
           GEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTL
Sbjct: 601 GEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTL 660

Query: 661 AGIVKEYGDVGIYVYLAGCSA 681
           AGIVKEYGDVGIYVYLAGCSA
Sbjct: 661 AGIVKEYGDVGIYVYLAGCSA 681


>gi|45827802 prestin isoform c [Homo sapiens]
          Length = 516

 Score =  987 bits (2552), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60
           MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
Sbjct: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60

Query: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120
           IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
Sbjct: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120

Query: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180
           IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
Sbjct: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180

Query: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240
           SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
Sbjct: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240

Query: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300
           FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
Sbjct: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300

Query: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360
           TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
Sbjct: 301 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT 360

Query: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420
           LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
Sbjct: 361 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM 420

Query: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480
           ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
Sbjct: 421 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL 480

Query: 481 FLGLDYGLITAVIIALLTVIYRTQS 505
           FLGLDYGLITAVIIALLTVIYRTQS
Sbjct: 481 FLGLDYGLITAVIIALLTVIYRTQS 505


>gi|45827804 prestin isoform d [Homo sapiens]
          Length = 335

 Score =  642 bits (1656), Expect = 0.0
 Identities = 324/324 (100%), Positives = 324/324 (100%)

Query: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60
           MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
Sbjct: 1   MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI 60

Query: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120
           IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
Sbjct: 61  IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV 120

Query: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180
           IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
Sbjct: 121 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM 180

Query: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240
           SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
Sbjct: 181 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI 240

Query: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300
           FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
Sbjct: 241 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG 300

Query: 301 TGISAGFNLKESYNVDVVGTLPLG 324
           TGISAGFNLKESYNVDVVGTLPLG
Sbjct: 301 TGISAGFNLKESYNVDVVGTLPLG 324


>gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo
           sapiens]
          Length = 740

 Score =  564 bits (1454), Expect = e-161
 Identities = 302/723 (41%), Positives = 451/723 (62%), Gaps = 38/723 (5%)

Query: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71

Query: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131

Query: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186

Query: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246

Query: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306

Query: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366

Query: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426

Query: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486

Query: 482 LGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQIN 541
           L LD GL+ AVI +LL V+ RTQ P Y VLG++P+TD+Y D+  Y E KE+ G+K+F+ +
Sbjct: 487 LNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSS 546

Query: 542 APIYYANSDLYSNALKRKTGVNPAVIMGARRKAMR--------------KYAKEVGNANM 587
           A +Y+AN++ YS+ALK++ GV+   ++  ++K ++              K  K+ G    
Sbjct: 547 ATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAGPLLS 606

Query: 588 ANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFT 647
           A     +  +    EDAT   +ED          K+     ++    P  + H++ILD  
Sbjct: 607 ACLAPQQVSSGDKMEDATANGQEDS---------KAPDGSTLKALGLPQPDFHSLILDLG 657

Query: 648 QVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIH 707
            ++F+D+V +K+L  I  ++ ++ + VY+A C + VV+ L    FF+     + LF S+H
Sbjct: 658 ALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVH 717

Query: 708 DAV 710
           DAV
Sbjct: 718 DAV 720


>gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo
           sapiens]
          Length = 759

 Score =  560 bits (1442), Expect = e-159
 Identities = 300/742 (40%), Positives = 456/742 (61%), Gaps = 57/742 (7%)

Query: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71

Query: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131

Query: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186

Query: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246

Query: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306

Query: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366

Query: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426

Query: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486

Query: 482 LGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQIN 541
           L LD GL+ AVI +LL V+ RTQ P Y VLG++P+TD+Y D+  Y E KE+ G+K+F+ +
Sbjct: 487 LNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSS 546

Query: 542 APIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKY----------------------- 578
           A +Y+AN++ YS+ALK++ GV+   ++  ++K ++K                        
Sbjct: 547 ATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKG 606

Query: 579 ----------AKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEE 628
                      +++ + N+ +  +++  +    EDAT   +ED          K+     
Sbjct: 607 ASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDS---------KAPDGST 657

Query: 629 MQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLT 688
           ++    P  + H++ILD   ++F+D+V +K+L  I  ++ ++ + VY+A C + VV+ L 
Sbjct: 658 LKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLE 717

Query: 689 RNRFFENPALWELLFHSIHDAV 710
              FF+     + LF S+HDAV
Sbjct: 718 AGHFFDASITKKHLFASVHDAV 739


>gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo
           sapiens]
          Length = 738

 Score =  559 bits (1440), Expect = e-159
 Identities = 296/728 (40%), Positives = 450/728 (61%), Gaps = 50/728 (6%)

Query: 16  YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYK 75
           Y++ERP+ +   L+E L      P +   + +    C+  +   ++   LP+  WLP Y 
Sbjct: 8   YHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALLLQHLPVLVWLPRYP 64

Query: 76  FKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIG 135
            ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV +Y   GTSRHIS+G
Sbjct: 65  VRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVG 124

Query: 136 PFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGV 195
            FAV+S+M+G V   L P  +     +N T    ARDA RV+VA ++++L G+ Q  LG+
Sbjct: 125 TFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVASTLSVLVGLFQVGLGL 179

Query: 196 CRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVK 255
             FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  S++Y+ + V   + 
Sbjct: 180 IHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLP 239

Query: 256 NLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNV 315
              V ++    +   +L+  K  N++ +++LP PIP E   ++  TGIS G  LK  + V
Sbjct: 240 QSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEV 299

Query: 316 DVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQEL 375
           DVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  A +HGY+VD NQEL
Sbjct: 300 DVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQEL 359

Query: 376 IALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESL 435
           +ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL ILL+I+  G LF  L
Sbjct: 360 VALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDL 419

Query: 436 PQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIA 495
           P+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ L LD GL+ AVI +
Sbjct: 420 PKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFS 479

Query: 496 LLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNA 555
           LL V+ RTQ P Y VLG++P+TD+Y D+  Y E KE+ G+K+F+ +A +Y+AN++ YS+A
Sbjct: 480 LLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDA 539

Query: 556 LKRKTGVNPAVIMGARRKAMRKY---------------------------------AKEV 582
           LK++ GV+   ++  ++K ++K                                   +++
Sbjct: 540 LKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDM 599

Query: 583 GNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTV 642
            + N+ +  +++  +    EDAT   +ED          K+     ++    P  + H++
Sbjct: 600 RSNNVEDCKMMQVSSGDKMEDATANGQEDS---------KAPDGSTLKALGLPQPDFHSL 650

Query: 643 ILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELL 702
           ILD   ++F+D+V +K+L  I  ++ ++ + VY+A C + VV+ L    FF+     + L
Sbjct: 651 ILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHL 710

Query: 703 FHSIHDAV 710
           F S+HDAV
Sbjct: 711 FASVHDAV 718


>gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo
           sapiens]
          Length = 758

 Score =  558 bits (1437), Expect = e-159
 Identities = 303/741 (40%), Positives = 451/741 (60%), Gaps = 56/741 (7%)

Query: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71

Query: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131

Query: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186

Query: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246

Query: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306

Query: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366

Query: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426

Query: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486

Query: 482 LGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQIN 541
           L LD GL+ AVI +LL V+ RTQ P Y VLG++P+TD+Y D+  Y E KE+ G+K+F+ +
Sbjct: 487 LNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSS 546

Query: 542 APIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKY------------------AKEVG 583
           A +Y+AN++ YS+ALK++ GV+   ++  ++K ++K                   A   G
Sbjct: 547 ATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKG 606

Query: 584 NANMANATVVKADAEVDG--------------EDATKPEEEDGEVKYPPIVIKSTFPEEM 629
            +   N      D   +               EDAT   +ED          K+     +
Sbjct: 607 ASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDS---------KAPDGSTL 657

Query: 630 QRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTR 689
           +    P  + H++ILD   ++F+D+V +K+L  I  ++ ++ + VY+A C + VV+ L  
Sbjct: 658 KALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEA 717

Query: 690 NRFFENPALWELLFHSIHDAV 710
             FF+     + LF S+HDAV
Sbjct: 718 GHFFDASITKKHLFASVHDAV 738


>gi|4505697 pendrin [Homo sapiens]
          Length = 780

 Score =  538 bits (1385), Expect = e-153
 Identities = 277/723 (38%), Positives = 437/723 (60%), Gaps = 14/723 (1%)

Query: 16  YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYK 75
           Y V RP++S    Q++   + +   ++ + L +  +C+ K+   ++   +PI +WLP Y+
Sbjct: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79

Query: 76  FKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIG 135
            KE++L D++SG+STG++   QG+A+A+LAAVP  +GLYS+F+P++ Y   GTSRHIS+G
Sbjct: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139

Query: 136 PFAVISLMIGGVAVRLVPDDIVIPGGVNATN------GTEARDALRVKVAMSVTLLSGII 189
           PF V+SLM+G V + + PD+  +    N T        T ARD  RV +A ++TLL GII
Sbjct: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199

Query: 190 QFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVA 249
           Q   G  + GF+  YL +PLV GFTTAAA  V  S LK +  V TK Y+G+ S++Y+ V 
Sbjct: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259

Query: 250 VLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNL 309
           + QN+ + N+     GL+   + +  KE N+RF+ K+P PIP+E    ++ T IS G NL
Sbjct: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319

Query: 310 KESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQV 369
           +++YN  +V ++P G LPP  P  SLF  +   + +IA+V +++ +S+ K  A K+ Y +
Sbjct: 320 EKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTI 379

Query: 370 DGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATG 429
           DGNQE IA G+ N     F  F  + +LSR+ VQE TGGKTQ+AG +++ ++++ ILA G
Sbjct: 380 DGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439

Query: 430 FLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLI 489
            L E L ++VL+A+VI NLKGMFMQ  D+P  WR +KI+  IW+ T + S+ LGLD GL+
Sbjct: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLL 499

Query: 490 TAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANS 549
             +I  LLTV+ R Q PS+  LG +P TD+Y     Y+ ++E  G+KI + ++PI+Y N 
Sbjct: 500 AGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNV 559

Query: 550 DLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANM-ANATVVKADAEVDGEDATKPE 608
           D +   +K   G +   +   R KA+RK  K + +  + A    + +DA V   +A +P+
Sbjct: 560 DGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDA-VSTNNAFEPD 618

Query: 609 E-----EDGEVKYPPIVIKSTFPEEMQ-RFMPPGDNVHTVILDFTQVNFIDSVGVKTLAG 662
           E     E+ ++    I I+  +  E+  +   P   +H+++LD   ++F+D VGV++L  
Sbjct: 619 EDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRV 678

Query: 663 IVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQ 722
           IVKE+  + + VY A     V+  L +  FF++    +  F ++HDA+L  Q +    E 
Sbjct: 679 IVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEG 738

Query: 723 EAS 725
           + S
Sbjct: 739 QGS 741


>gi|4557535 solute carrier family 26, member 3 [Homo sapiens]
          Length = 764

 Score =  513 bits (1322), Expect = e-145
 Identities = 288/735 (39%), Positives = 432/735 (58%), Gaps = 24/735 (3%)

Query: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74
           +Y V RP++S    +E      +   +  D LK   +C+P+K + I+    PI  WLPAY
Sbjct: 8   QYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAY 67

Query: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134
           + KE++L D+VSGISTG++ + QGLAFA+L  +PP++GLY+SF+P I+Y F GTSRHIS+
Sbjct: 68  RLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISV 127

Query: 135 GPFAVISLMIG----GVAVRLVPDDIVIPGGV-NATNGTEARDALRVKVAM--SVTLLSG 187
           GPF ++S+M+G    G   + VPD      G+ N +N +   D  RV+VA   SVT+LSG
Sbjct: 128 GPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSG 187

Query: 188 IIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYS---GIFSVV 244
           IIQ   G+ R GFV IYL+E L+ GFTTAAAVHV  S LK++F +    ++    IF V+
Sbjct: 188 IIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVL 247

Query: 245 YSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGIS 304
           YS   V   ++  N+  L   L+V  ++   KE N+RFK+KLP PIP+EF   V+  G+S
Sbjct: 248 YS---VFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVS 304

Query: 305 AGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANK 364
            G + K  + V VVG +  G  PP  PD   F     D   IA+V F+V  S+A   + K
Sbjct: 305 YGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLK 364

Query: 365 HGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLV 424
           + Y +DGNQELIALGL N +  +F+ F+ S +LSRS VQE TGGKTQ+AG + ++++L+V
Sbjct: 365 YDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIV 424

Query: 425 ILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGL 484
           +LA GFL   L ++VL+A+ + NLKGM MQF+++   WR  K +  IW+ TF+ ++ LGL
Sbjct: 425 VLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGL 484

Query: 485 DYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPI 544
             GL  +V   LLT+++RTQ P    L  +  T++Y +   Y ++ E  G+KIF+  +PI
Sbjct: 485 GLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPI 544

Query: 545 YYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVDGEDA 604
           Y+AN   +   L    G +P  I+  R KA+RK  K +    +   T       VD    
Sbjct: 545 YFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRK-LQKQGLLQVTPKGFICTVDTIKD 603

Query: 605 TKPEEEDGEVKYPPIVIKST---FPEEMQRFMP-----PGDNVHTVILDFTQVNFIDSVG 656
           +  E ++ +++     I +T   F  +    +P     P  ++H++ILDF+ V+F+D   
Sbjct: 604 SDEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSS 663

Query: 657 VKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLR 716
           V+ L  I++E+  + + VY+ G     +  L R  FF+      + F +IHDAVL   ++
Sbjct: 664 VRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMK 723

Query: 717 EALAEQEASAPPSQE 731
           +  +  + +  PSQE
Sbjct: 724 KDYSTSKFN--PSQE 736


>gi|16418413 solute carrier family 26, member 9 isoform a [Homo
           sapiens]
          Length = 791

 Score =  492 bits (1266), Expect = e-139
 Identities = 273/764 (35%), Positives = 437/764 (57%), Gaps = 47/764 (6%)

Query: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74
           RY V+R  +S  +  +    KD+    + +KL+ AF C+  KI+ +++  LP+  WLP Y
Sbjct: 7   RYVVDRAAYSLTLFDDEFEKKDRTYP-VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65

Query: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134
           K K+Y++ DL+ G+S G +Q+PQG+AFA+LA +P + GLYSSF+P++ Y FLG    +  
Sbjct: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125

Query: 135 GPFAVISLMIGGVAVRLVPDDIVIPGGVNATN----GTEARDALRVKVAMSVTLLSGIIQ 190
           G FAVIS+++G + ++L P+        NATN     T A +A R+ V+ ++  L+ IIQ
Sbjct: 126 GTFAVISILVGNICLQLAPESKFQVFN-NATNESYVDTAAMEAERLHVSATLACLTAIIQ 184

Query: 191 FCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAV 250
             LG  +FGFVAIYL+E  +RGF TAA + +  S+LKY+FG+    Y+G  S+V++ + +
Sbjct: 185 MGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDI 244

Query: 251 LQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLK 310
            +N+ + N+ SL   L+    L+  KE N R+  K+  PIP E   VV+ T IS G  + 
Sbjct: 245 CKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMP 304

Query: 311 ESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVD 370
           + Y++ +VG +  G   P +P  S +  +   A ++AIV + + ++M +TLANKHGY VD
Sbjct: 305 KKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVD 364

Query: 371 GNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGF 430
            NQE+IALG  N  GS F+   I C+LS +L  +G GGK+Q+A    SL++++ +L  G 
Sbjct: 365 SNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGI 424

Query: 431 LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLIT 490
               LP++VL A++ VNLK    Q +D  + WR SK++  IW+ +F+SS FL L YG+  
Sbjct: 425 YLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAV 484

Query: 491 AVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSD 550
            V  ++L V+++TQ  +   L ++ +TD+Y++   Y   ++I GIKI    +P+Y+ANS+
Sbjct: 485 GVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSE 544

Query: 551 LYSNALKRKTGVNPAVIMGARRKAMRKYAK-------EVGNANMANATVVKADAEVDGED 603
           ++   +  KTG++P  ++ A++K ++K  K       +  +  M   TV   + + D E+
Sbjct: 545 IFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFEN 604

Query: 604 AT---------------------KPEEEDGEVKYPPIVIKST-FPEEMQRFMPPGDNVHT 641
           A                       P+        PP   ++   P +M   +PP    HT
Sbjct: 605 APPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHT 664

Query: 642 VILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPAL-WE 700
           +ILD + V+F+D +G+K LA +   YG +G+ V+L    AQV ND++    FE+ +L  +
Sbjct: 665 LILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECK 724

Query: 701 LLFHSIHDAVL-----------GSQLREALAEQEASAPPSQEDL 733
            +F SIHDAVL           G   + A  + E S   S+ED+
Sbjct: 725 HVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDI 768


>gi|217272867 solute carrier family 26, member 9 isoform b [Homo
           sapiens]
          Length = 887

 Score =  492 bits (1266), Expect = e-139
 Identities = 273/764 (35%), Positives = 437/764 (57%), Gaps = 47/764 (6%)

Query: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74
           RY V+R  +S  +  +    KD+    + +KL+ AF C+  KI+ +++  LP+  WLP Y
Sbjct: 7   RYVVDRAAYSLTLFDDEFEKKDRTYP-VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65

Query: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134
           K K+Y++ DL+ G+S G +Q+PQG+AFA+LA +P + GLYSSF+P++ Y FLG    +  
Sbjct: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125

Query: 135 GPFAVISLMIGGVAVRLVPDDIVIPGGVNATN----GTEARDALRVKVAMSVTLLSGIIQ 190
           G FAVIS+++G + ++L P+        NATN     T A +A R+ V+ ++  L+ IIQ
Sbjct: 126 GTFAVISILVGNICLQLAPESKFQVFN-NATNESYVDTAAMEAERLHVSATLACLTAIIQ 184

Query: 191 FCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAV 250
             LG  +FGFVAIYL+E  +RGF TAA + +  S+LKY+FG+    Y+G  S+V++ + +
Sbjct: 185 MGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDI 244

Query: 251 LQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLK 310
            +N+ + N+ SL   L+    L+  KE N R+  K+  PIP E   VV+ T IS G  + 
Sbjct: 245 CKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMP 304

Query: 311 ESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVD 370
           + Y++ +VG +  G   P +P  S +  +   A ++AIV + + ++M +TLANKHGY VD
Sbjct: 305 KKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVD 364

Query: 371 GNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGF 430
            NQE+IALG  N  GS F+   I C+LS +L  +G GGK+Q+A    SL++++ +L  G 
Sbjct: 365 SNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGI 424

Query: 431 LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLIT 490
               LP++VL A++ VNLK    Q +D  + WR SK++  IW+ +F+SS FL L YG+  
Sbjct: 425 YLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAV 484

Query: 491 AVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSD 550
            V  ++L V+++TQ  +   L ++ +TD+Y++   Y   ++I GIKI    +P+Y+ANS+
Sbjct: 485 GVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSE 544

Query: 551 LYSNALKRKTGVNPAVIMGARRKAMRKYAK-------EVGNANMANATVVKADAEVDGED 603
           ++   +  KTG++P  ++ A++K ++K  K       +  +  M   TV   + + D E+
Sbjct: 545 IFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFEN 604

Query: 604 AT---------------------KPEEEDGEVKYPPIVIKST-FPEEMQRFMPPGDNVHT 641
           A                       P+        PP   ++   P +M   +PP    HT
Sbjct: 605 APPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHT 664

Query: 642 VILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPAL-WE 700
           +ILD + V+F+D +G+K LA +   YG +G+ V+L    AQV ND++    FE+ +L  +
Sbjct: 665 LILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECK 724

Query: 701 LLFHSIHDAVL-----------GSQLREALAEQEASAPPSQEDL 733
            +F SIHDAVL           G   + A  + E S   S+ED+
Sbjct: 725 HVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDI 768


>gi|100913030 solute carrier family 26 member 2 [Homo sapiens]
          Length = 739

 Score =  461 bits (1187), Expect = e-130
 Identities = 257/702 (36%), Positives = 401/702 (57%), Gaps = 53/702 (7%)

Query: 25  HPVLQERLHTKD-KVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGD 83
           H +L ER    D    + +  KL++   C+P K +N+I  FLP+ +WLP Y  K+ +LGD
Sbjct: 52  HRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGD 111

Query: 84  LVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLM 143
           ++SG+  G+L +PQ +A+++LA   P++GLY+SF+  I+Y  LGTSRHIS+G F V+ LM
Sbjct: 112 VMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCLM 171

Query: 144 IGGVAVRLV-----------PDDIVIPGGVNATNGTEAR----DALRVKVAMSVTLLSGI 188
           IG    R +           P   ++  G    N T  R        + V  +VT ++G+
Sbjct: 172 IGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGV 231

Query: 189 IQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTV 248
            Q  +G  + GFV++YL++ L+ GF T A+  + TS  KYL G+   R +G+ S++ + +
Sbjct: 232 YQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWI 291

Query: 249 AVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFN 308
            V +N+   N+C L   L+   +LL  KE NE FK KL APIP+E   VV  T  S    
Sbjct: 292 HVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFGK 351

Query: 309 LKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQ 368
           L E+YN  + G +P G +PP  P+ +L   V VDAIAI+I+GF++T+S+++  A KHGY 
Sbjct: 352 LHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYT 411

Query: 369 VDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILAT 428
           V  NQE+ A+G CN I S F  F+ S +L+++LV+E TG  TQL+G + +L++LLV+L  
Sbjct: 412 VKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVI 471

Query: 429 GFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGL 488
             LF SL ++VL  I IVNL+G   +F DLP  W  S+++  IW  T +SS  L  + GL
Sbjct: 472 APLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGL 531

Query: 489 ITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYAN 548
           +  V  ++  VI RTQ P   +LG + E++V+  + AY+ ++  PGIKIF+  AP+YY N
Sbjct: 532 LVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYIN 591

Query: 549 SDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVDGEDATKPE 608
            + + +AL ++T VNP +I  A +KA ++  KE          VV      D        
Sbjct: 592 KECFKSALYKQT-VNPILIKVAWKKAAKRKIKE---------KVVTLGGIQD-------- 633

Query: 609 EEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYG 668
           E   ++ + P+                   +HT+++D + + F+D+ G+ TL  + ++Y 
Sbjct: 634 EMSVQLSHDPL------------------ELHTIVIDCSAIQFLDTAGIHTLKEVRRDYE 675

Query: 669 DVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAV 710
            +GI V LA C+  V + LT   + +      LLF+S+++A+
Sbjct: 676 AIGIQVLLAQCNPTVRDSLTNGEYCKKEE-ENLLFYSVYEAM 716


>gi|47131207 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  414 bits (1064), Expect = e-115
 Identities = 233/683 (34%), Positives = 389/683 (56%), Gaps = 49/683 (7%)

Query: 51  TCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPI 110
           +C+   +R ++   LP T+WL  Y+ +EY+ GD++SG+  G++ +PQ +A+++LA + PI
Sbjct: 40  SCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPI 99

Query: 111 FGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVP-------DDIVIPGGVN 163
           + LY+SF+  ++Y  +GTSRH+S+G F+++ LM+G V  R +         D + PG  +
Sbjct: 100 YSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANS 159

Query: 164 AT-NGTEA-----RDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAA 217
           +T NG+ A     RD   ++VA ++TL++G+ Q  +GV R GFV+ YL++PL+ GF   A
Sbjct: 160 STLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGA 219

Query: 218 AVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKE 277
           +V + TS LK+L GV+  R+ G   VV + +++L+     NVC +    +   +LL  KE
Sbjct: 220 SVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKE 279

Query: 278 FNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFH 337
            ++R++ +L  P+P E   +V+ T +S    L + +   V G +P G +PP  P+  L  
Sbjct: 280 LSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQ 339

Query: 338 LVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSL 397
            V +DA+A+A+V  + +IS+A+  A  HGY V  NQEL+A+G CN + +    F+ S +L
Sbjct: 340 RVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAAL 399

Query: 398 SRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSD 457
           ++SLV+  TG +TQL+  +++ ++LLV+LA   LF  L ++VL+ +++V+L+G   +  D
Sbjct: 400 AKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWD 459

Query: 458 LPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPET 517
           LP  WR S  +  +W  T  + + +  + GL+  VI++LL++  RTQ P   +L ++ +T
Sbjct: 460 LPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDT 519

Query: 518 DVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRK 577
             Y D   +E +   PG+++F+   P+YYAN D +  +L   TG++ A  M ARRK    
Sbjct: 520 AFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLD-AGCMAARRK---- 574

Query: 578 YAKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGD 637
                      + T V       GED              P+  ++         +P   
Sbjct: 575 --------EGGSETGVGEGGPAQGEDLG------------PVSTRAAL-------VPAAA 607

Query: 638 NVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFF-ENP 696
             HTV++D   + F+D+ GV TL  + ++YG +GI + LA CS  V + L+R  F  E P
Sbjct: 608 GFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEGP 667

Query: 697 ---ALWELLFHSIHDAVLGSQLR 716
              A  E LF S+HDAV  ++ R
Sbjct: 668 GDTAEEEQLFLSVHDAVQTARAR 690


>gi|20336272 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  414 bits (1064), Expect = e-115
 Identities = 233/683 (34%), Positives = 389/683 (56%), Gaps = 49/683 (7%)

Query: 51  TCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPI 110
           +C+   +R ++   LP T+WL  Y+ +EY+ GD++SG+  G++ +PQ +A+++LA + PI
Sbjct: 40  SCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPI 99

Query: 111 FGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVP-------DDIVIPGGVN 163
           + LY+SF+  ++Y  +GTSRH+S+G F+++ LM+G V  R +         D + PG  +
Sbjct: 100 YSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANS 159

Query: 164 AT-NGTEA-----RDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAA 217
           +T NG+ A     RD   ++VA ++TL++G+ Q  +GV R GFV+ YL++PL+ GF   A
Sbjct: 160 STLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGA 219

Query: 218 AVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKE 277
           +V + TS LK+L GV+  R+ G   VV + +++L+     NVC +    +   +LL  KE
Sbjct: 220 SVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKE 279

Query: 278 FNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFH 337
            ++R++ +L  P+P E   +V+ T +S    L + +   V G +P G +PP  P+  L  
Sbjct: 280 LSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQ 339

Query: 338 LVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSL 397
            V +DA+A+A+V  + +IS+A+  A  HGY V  NQEL+A+G CN + +    F+ S +L
Sbjct: 340 RVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAAL 399

Query: 398 SRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSD 457
           ++SLV+  TG +TQL+  +++ ++LLV+LA   LF  L ++VL+ +++V+L+G   +  D
Sbjct: 400 AKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWD 459

Query: 458 LPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPET 517
           LP  WR S  +  +W  T  + + +  + GL+  VI++LL++  RTQ P   +L ++ +T
Sbjct: 460 LPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDT 519

Query: 518 DVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRK 577
             Y D   +E +   PG+++F+   P+YYAN D +  +L   TG++ A  M ARRK    
Sbjct: 520 AFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLD-AGCMAARRK---- 574

Query: 578 YAKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGD 637
                      + T V       GED              P+  ++         +P   
Sbjct: 575 --------EGGSETGVGEGGPAQGEDLG------------PVSTRAAL-------VPAAA 607

Query: 638 NVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFF-ENP 696
             HTV++D   + F+D+ GV TL  + ++YG +GI + LA CS  V + L+R  F  E P
Sbjct: 608 GFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEGP 667

Query: 697 ---ALWELLFHSIHDAVLGSQLR 716
              A  E LF S+HDAV  ++ R
Sbjct: 668 GDTAEEEQLFLSVHDAVQTARAR 690


>gi|16306483 solute carrier family 26, member 7 isoform a [Homo
           sapiens]
          Length = 656

 Score =  300 bits (769), Expect = 2e-81
 Identities = 163/487 (33%), Positives = 267/487 (54%), Gaps = 4/487 (0%)

Query: 65  LPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYC 124
           LPI  W P Y  KE +L D VSGI   V Q+ QGLAFA+L++V P+FGLY S +P I+Y 
Sbjct: 32  LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91

Query: 125 FLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATNGTEARDALRVKVAMSV 182
             G   H++ G FA+ SL+      R+VP ++  +      +  G    +  R+ VA +V
Sbjct: 92  IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAV 151

Query: 183 TLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFS 242
           + L G+IQ  + V + G     +TEP++   TT AA HV TS +KYL G+K    SG   
Sbjct: 152 SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLG 211

Query: 243 VVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTG 302
             Y    V +N+K++ + +L + L+   +L+  KE NE+FK K+   +P++   ++  + 
Sbjct: 212 FFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271

Query: 303 ISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLA 362
                N++ +Y ++VVG +P G+  P  P  ++   V  +A  +A+VG+  ++++A+  A
Sbjct: 272 ACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSA 331

Query: 363 NKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMIL 422
            K  Y +D NQE +A GL N + S F     + ++ R+     TG KTQ+A  ++ + +L
Sbjct: 332 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL 391

Query: 423 LVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFL 482
           +VI A G L   LP  VL++I++V LKGM +QF DL  +W   KI+  IW++T+V ++  
Sbjct: 392 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF 451

Query: 483 GLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINA 542
             + GL+  V+  +  VI R        +  + E +  +  +   E   +  +KI  IN 
Sbjct: 452 AANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSET--LQQVKIISINN 509

Query: 543 PIYYANS 549
           P+ + N+
Sbjct: 510 PLVFLNA 516


>gi|20336282 solute carrier family 26, member 7 isoform b [Homo
           sapiens]
          Length = 663

 Score =  300 bits (769), Expect = 2e-81
 Identities = 163/487 (33%), Positives = 267/487 (54%), Gaps = 4/487 (0%)

Query: 65  LPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYC 124
           LPI  W P Y  KE +L D VSGI   V Q+ QGLAFA+L++V P+FGLY S +P I+Y 
Sbjct: 32  LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91

Query: 125 FLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATNGTEARDALRVKVAMSV 182
             G   H++ G FA+ SL+      R+VP ++  +      +  G    +  R+ VA +V
Sbjct: 92  IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAV 151

Query: 183 TLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFS 242
           + L G+IQ  + V + G     +TEP++   TT AA HV TS +KYL G+K    SG   
Sbjct: 152 SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLG 211

Query: 243 VVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTG 302
             Y    V +N+K++ + +L + L+   +L+  KE NE+FK K+   +P++   ++  + 
Sbjct: 212 FFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271

Query: 303 ISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLA 362
                N++ +Y ++VVG +P G+  P  P  ++   V  +A  +A+VG+  ++++A+  A
Sbjct: 272 ACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSA 331

Query: 363 NKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMIL 422
            K  Y +D NQE +A GL N + S F     + ++ R+     TG KTQ+A  ++ + +L
Sbjct: 332 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL 391

Query: 423 LVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFL 482
           +VI A G L   LP  VL++I++V LKGM +QF DL  +W   KI+  IW++T+V ++  
Sbjct: 392 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF 451

Query: 483 GLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINA 542
             + GL+  V+  +  VI R        +  + E +  +  +   E   +  +KI  IN 
Sbjct: 452 AANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSET--LQQVKIISINN 509

Query: 543 PIYYANS 549
           P+ + N+
Sbjct: 510 PLVFLNA 516


>gi|16418457 solute carrier family 26, member 8 isoform a [Homo
           sapiens]
          Length = 970

 Score =  282 bits (722), Expect = 7e-76
 Identities = 158/505 (31%), Positives = 274/505 (54%), Gaps = 10/505 (1%)

Query: 52  CTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAA--VPP 109
           C+  +    +    P  +W+  Y+ K+++LGDL++GIS G++Q+PQGL  ++LA   +PP
Sbjct: 64  CSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPP 123

Query: 110 IFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIGGVAVRLVPDDIVIPGGVNATNGT 168
           +   Y++F   ++Y   G+   +SIG F ++S L+I  + V    +  ++ G     N  
Sbjct: 124 LNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSF-VKNEF 182

Query: 169 EARDALR-----VKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFT 223
            A   L      + V  + T L+GIIQ  +GV   GF+A YL E  +  +  A A+H+  
Sbjct: 183 SAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIML 242

Query: 224 SMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFK 283
           S L ++FG+    ++G  S  Y  +     +   N  S+ V L V   L   K     F 
Sbjct: 243 SQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFN 302

Query: 284 EKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDA 343
           +  P   P+E F ++  T I+   ++    +  ++  +P   L P  PD SL   + + A
Sbjct: 303 Q-YPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQA 361

Query: 344 IAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQ 403
            ++++V   + I + K +A+ H Y V+ NQ+LIA+GLCN + S F++   + +++R+++Q
Sbjct: 362 FSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQ 421

Query: 404 EGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWR 463
           + +GG+ Q A  + + ++LL+++  G  F +LP AVL+ I++ N+       S+LP  WR
Sbjct: 422 DKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWR 481

Query: 464 TSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDI 523
             + +  +W+ TF SS+FLGLD GLI +V+ A      R+      +LG++P T++Y  I
Sbjct: 482 QDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSI 541

Query: 524 DAYEEVKEIPGIKIFQINAPIYYAN 548
           + Y E+  IPG+KIFQ  + I + N
Sbjct: 542 NDYREIITIPGVKIFQCCSSITFVN 566



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 34/93 (36%), Positives = 53/93 (56%)

Query: 638 NVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPA 697
           +VHT+ILDF+ V+++DS G+  L  I   + +  I + +AGC + +V    RN FF+   
Sbjct: 720 SVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGI 779

Query: 698 LWELLFHSIHDAVLGSQLREALAEQEASAPPSQ 730
               LF S+HDAVL +  R+ +   E S   S+
Sbjct: 780 TKTQLFLSVHDAVLFALSRKVIGSSELSIDESE 812


>gi|65506789 solute carrier family 26, member 10 [Homo sapiens]
          Length = 563

 Score =  258 bits (659), Expect = 1e-68
 Identities = 142/374 (37%), Positives = 221/374 (59%), Gaps = 3/374 (0%)

Query: 98  GLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIV 157
           G+AFA+LA+VPP+FGLY+SF+PV++Y  LGT RH+S G FA++SLM G    RLVP+ +V
Sbjct: 41  GMAFALLASVPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILSLMTGSAVERLVPEPLV 100

Query: 158 IPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAA 217
             G ++     E  DA RV VA +V   SG +   + V + G ++ +L+EP+V+  T+ A
Sbjct: 101 --GNLSGIE-KEQLDAQRVGVAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVVKALTSGA 157

Query: 218 AVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKE 277
           A+HV  S L  L G+   R  G FS+  +  ++L  +   +   L +  +   LL+  KE
Sbjct: 158 ALHVLLSQLPSLLGLSLPRQIGCFSLFKTLASLLTALPRSSPAELTISALSLALLVPVKE 217

Query: 278 FNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFH 337
            N RF+++LP PIP E   V++ + +    ++   Y V +VG LP G   P  P+ +   
Sbjct: 218 LNVRFRDRLPTPIPGEVVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQPLLPNLAELP 277

Query: 338 LVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSL 397
            +  D++ IA+V F+V+ S+A   A+K+ Y +D NQE +A G  N I SLF  F  S +L
Sbjct: 278 RILADSLPIALVSFAVSASLASIHADKYSYTIDSNQEFLAHGASNLISSLFSCFPNSATL 337

Query: 398 SRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSD 457
           + + +    GGKTQLAG  +  ++L V+L  G  F  LP+AVL+ I I +++ +F Q  +
Sbjct: 338 ATTNLLVDAGGKTQLAGLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSMRQVFCQMQE 397

Query: 458 LPFFWRTSKIELTI 471
           LP  W  S+++  +
Sbjct: 398 LPQLWHISRVDFLL 411



 Score = 36.6 bits (83), Expect = 0.087
 Identities = 29/85 (34%), Positives = 41/85 (48%), Gaps = 8/85 (9%)

Query: 639 VHTVILDFTQVNFIDSVGVKTLAGIVKEYG----DVGIYVYLAGCSAQVVNDLTRNRFFE 694
           V  V+LDF+ V F D+ G + +  + +       D  I + LA C+A V   LTR    +
Sbjct: 464 VRVVVLDFSGVTFADAAGAREVVQVRERLASRCRDARIRLLLAQCNALVQGTLTRVGLLD 523

Query: 695 NPALWELLFHSIHDA---VLGSQLR 716
                + LF S+ DA    LGS LR
Sbjct: 524 R-VTPDQLFVSVQDAAAYALGSLLR 547


>gi|217272870 solute carrier family 26, member 9 isoform c [Homo
           sapiens]
          Length = 459

 Score =  256 bits (655), Expect = 4e-68
 Identities = 147/432 (34%), Positives = 237/432 (54%), Gaps = 41/432 (9%)

Query: 343 AIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLV 402
           A ++AIV + + ++M +TLANKHGY VD NQE+IALG  N  GS F+   I C+LS +L 
Sbjct: 5   AFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLA 64

Query: 403 QEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFW 462
            +G GGK+Q+A    SL++++ +L  G     LP++VL A++ VNLK    Q +D  + W
Sbjct: 65  VDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLW 124

Query: 463 RTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYID 522
           R SK++  IW+ +F+SS FL L YG+   V  ++L V+++TQ  +   L ++ +TD+Y++
Sbjct: 125 RKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVN 184

Query: 523 IDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAK-- 580
              Y   ++I GIKI    +P+Y+ANS+++   +  KTG++P  ++ A++K ++K  K  
Sbjct: 185 PKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRR 244

Query: 581 -----EVGNANMANATVVKADAEVDGEDAT---------------------KPEEEDGEV 614
                +  +  M   TV   + + D E+A                       P+      
Sbjct: 245 MRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQ 304

Query: 615 KYPPIVIKST-FPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIY 673
             PP   ++   P +M   +PP    HT+ILD + V+F+D +G+K LA +   YG +G+ 
Sbjct: 305 SEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVK 364

Query: 674 VYLAGCSAQVVNDLTRNRFFENPAL-WELLFHSIHDAVL-----------GSQLREALAE 721
           V+L    AQV ND++    FE+ +L  + +F SIHDAVL           G   + A  +
Sbjct: 365 VFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGD 424

Query: 722 QEASAPPSQEDL 733
            E S   S+ED+
Sbjct: 425 AELSLYDSEEDI 436


>gi|85540447 solute carrier family 26, member 11 [Homo sapiens]
          Length = 606

 Score =  186 bits (473), Expect = 5e-47
 Identities = 140/492 (28%), Positives = 235/492 (47%), Gaps = 68/492 (13%)

Query: 49  AFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVP 108
           A  C+P  ++      LPI  WLP+Y   +++  D V+G+S G+  +PQ LA+A +A +P
Sbjct: 22  ACCCSPAALQRR----LPILAWLPSYSL-QWLKMDFVAGLSVGLTAIPQALAYAEVAGLP 76

Query: 109 PIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGT 168
           P +GLYS+F    +Y FLGTSR +++GP A++SL++                        
Sbjct: 77  PQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVSFYTFH------------------ 118

Query: 169 EARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKY 228
                     A+ +  LSG IQ  +GV R GF+  +++ P+++GFT+AAAV +    +K 
Sbjct: 119 ------EPAYAVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKN 172

Query: 229 LFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPA 288
           L G++       F  VY T      +    V    +GL+   LLL  K   +      P 
Sbjct: 173 LLGLQNIP-RPFFLQVYHT---FLRIAETRVGDAVLGLVCMLLLLVLKLMRDHVPPVHPE 228

Query: 289 PIP-------LEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGL-------LPP------ 328
             P       L + A      +   F    +Y+ +V G  P  L       LPP      
Sbjct: 229 MPPGVRLSRGLVWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPVRIPPF 288

Query: 329 ----ANPDTSLFHLVYVDAIAIAIV---GFSVTISMAKTLANKHGYQVDGNQELIALGLC 381
               AN   S   +V      +A+V   G   +I++AK  A+++ Y++D NQEL+A+GL 
Sbjct: 289 SVTTANGTISFTEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLT 348

Query: 382 NSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLS 441
           N +GSL  ++ ++ S  R+ V   +G  T   G +  +++LL +     LF  +P++ L+
Sbjct: 349 NMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALA 408

Query: 442 AIVIVNLKGMFMQFSDLPFF---WRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLT 498
           A++I+ +  +F    D   F   WR  +++L     TF+   F  + YG++   +++LL 
Sbjct: 409 AVIIMAVAPLF----DTKIFRTLWRVKRLDLLPLCVTFL-LCFWEVQYGILAGALVSLLM 463

Query: 499 VIYRTQSPSYKV 510
           +++    P  KV
Sbjct: 464 LLHSAARPETKV 475


>gi|20336285 solute carrier family 26, member 8 isoform b [Homo
           sapiens]
          Length = 865

 Score =  171 bits (432), Expect = 3e-42
 Identities = 81/232 (34%), Positives = 141/232 (60%)

Query: 317 VVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELI 376
           ++  +P   L P  PD SL   + + A ++++V   + I + K +A+ H Y V+ NQ+LI
Sbjct: 230 LIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLI 289

Query: 377 ALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLP 436
           A+GLCN + S F++   + +++R+++Q+ +GG+ Q A  + + ++LL+++  G  F +LP
Sbjct: 290 AIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLP 349

Query: 437 QAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIAL 496
            AVL+ I++ N+       S+LP  WR  + +  +W+ TF SS+FLGLD GLI +V+ A 
Sbjct: 350 NAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAF 409

Query: 497 LTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYAN 548
                R+      +LG++P T++Y  I+ Y E+  IPG+KIFQ  + I + N
Sbjct: 410 FITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVN 461



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 45/147 (30%), Positives = 79/147 (53%), Gaps = 9/147 (6%)

Query: 52  CTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLA--AVPP 109
           C+  +    +    P  +W+  Y+ K+++LGDL++GIS G++Q+PQGL  ++LA   +PP
Sbjct: 64  CSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPP 123

Query: 110 IFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIGGVAVRLVPDDIVIPGGVNATNGT 168
           +   Y++F   ++Y   G+   +SIG F ++S L+I  + V    +  ++ G     N  
Sbjct: 124 LNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSF-VKNEF 182

Query: 169 EARDAL-----RVKVAMSVTLLSGIIQ 190
            A   L      + V  + T L+GIIQ
Sbjct: 183 SAPSYLMGYNKSLSVVATTTFLTGIIQ 209



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 34/93 (36%), Positives = 53/93 (56%)

Query: 638 NVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPA 697
           +VHT+ILDF+ V+++DS G+  L  I   + +  I + +AGC + +V    RN FF+   
Sbjct: 615 SVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGI 674

Query: 698 LWELLFHSIHDAVLGSQLREALAEQEASAPPSQ 730
               LF S+HDAVL +  R+ +   E S   S+
Sbjct: 675 TKTQLFLSVHDAVLFALSRKVIGSSELSIDESE 707


>gi|20336274 solute carrier family 26, member 1 isoform b [Homo
           sapiens]
          Length = 224

 Score =  109 bits (273), Expect = 8e-24
 Identities = 56/157 (35%), Positives = 100/157 (63%), Gaps = 13/157 (8%)

Query: 51  TCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPI 110
           +C+   +R ++   LP T+WL  Y+ +EY+ GD++SG+  G++ +PQ +A+++LA + PI
Sbjct: 40  SCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPI 99

Query: 111 FGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLV-------PDDIVIPGGVN 163
           + LY+SF+  ++Y  +GTSRH+S+G F+++ LM+G V  R +         D + PG  +
Sbjct: 100 YSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANS 159

Query: 164 AT-NGTEA-----RDALRVKVAMSVTLLSGIIQFCLG 194
           +T NG+ A     RD   ++VA ++TL++G+ Q   G
Sbjct: 160 STLNGSAAMLDCGRDCYAIRVATALTLMTGLYQTSWG 196


>gi|32401433 G protein-coupled receptor 142 [Homo sapiens]
          Length = 462

 Score = 30.8 bits (68), Expect = 4.8
 Identities = 19/44 (43%), Positives = 25/44 (56%), Gaps = 2/44 (4%)

Query: 480 LFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDI 523
           L LGL   L+TAV +A L    RT+ PSY  L  L  +D+ I +
Sbjct: 167 LGLGLPVSLLTAVALARLAT--RTRRPSYYYLLALTASDIIIQV 208


>gi|18379366 zinc metallopeptidase STE24 [Homo sapiens]
          Length = 475

 Score = 30.0 bits (66), Expect = 8.1
 Identities = 38/146 (26%), Positives = 64/146 (43%), Gaps = 16/146 (10%)

Query: 421 ILLVILATGF-LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTS--KIELTIWLTTFV 477
           ++ ++LAT F     LP ++ +  VI    G   Q   L FF + +  K  +T  +   V
Sbjct: 124 LVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQ--TLGFFMKDAIKKFVVTQCILLPV 181

Query: 478 SSLFL-----GLDY-----GLITAVIIALLTVIYRTQ-SPSYKVLGKLPETDVYIDIDAY 526
           SSL L     G DY      L T V+  +L  IY    +P +     LPE  +  +I+  
Sbjct: 182 SSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKEEIEVM 241

Query: 527 EEVKEIPGIKIFQINAPIYYANSDLY 552
            +  + P  K++ +      ++S+ Y
Sbjct: 242 AKSIDFPLTKVYVVEGSKRSSHSNAY 267


>gi|45827778 reticulon 1 isoform B [Homo sapiens]
          Length = 356

 Score = 30.0 bits (66), Expect = 8.1
 Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 8/74 (10%)

Query: 466 KIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIY---RTQSPSYKVLGKLPETDVYID 522
           K  + +WL T+V +LF GL   L+  V +  L V+Y   + Q   Y  L +     V   
Sbjct: 284 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAK 343

Query: 523 IDAYEEVKEIPGIK 536
           I A     +IPG K
Sbjct: 344 IQA-----KIPGAK 352


>gi|45827776 reticulon 1 isoform C [Homo sapiens]
          Length = 208

 Score = 30.0 bits (66), Expect = 8.1
 Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 8/74 (10%)

Query: 466 KIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIY---RTQSPSYKVLGKLPETDVYID 522
           K  + +WL T+V +LF GL   L+  V +  L V+Y   + Q   Y  L +     V   
Sbjct: 136 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAK 195

Query: 523 IDAYEEVKEIPGIK 536
           I A     +IPG K
Sbjct: 196 IQA-----KIPGAK 204


>gi|10863935 reticulon 1 isoform A [Homo sapiens]
          Length = 776

 Score = 30.0 bits (66), Expect = 8.1
 Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 8/74 (10%)

Query: 466 KIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIY---RTQSPSYKVLGKLPETDVYID 522
           K  + +WL T+V +LF GL   L+  V +  L V+Y   + Q   Y  L +     V   
Sbjct: 704 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAK 763

Query: 523 IDAYEEVKEIPGIK 536
           I A     +IPG K
Sbjct: 764 IQA-----KIPGAK 772


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.139    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,366,401
Number of Sequences: 37866
Number of extensions: 1128533
Number of successful extensions: 2834
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2760
Number of HSP's gapped (non-prelim): 43
length of query: 744
length of database: 18,247,518
effective HSP length: 110
effective length of query: 634
effective length of database: 14,082,258
effective search space: 8928151572
effective search space used: 8928151572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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