Search of human proteins with 39725942

Search of human proteins with 39725942

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39725942 twinkle [Homo sapiens]
         (684 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39725942 twinkle [Homo sapiens]                                   1388   0.0  
gi|90421313 cystic fibrosis transmembrane conductance regulator ...    33   0.67 
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso...    33   0.67 
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof...    33   0.67 
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof...    33   0.67 
gi|17149853 WAF-1/CIP1 stabilizing protein 39 [Homo sapiens]           33   1.1  
gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]            32   1.9  
gi|38505213 YTH domain containing 2 [Homo sapiens]                     32   1.9  
gi|119392094 immunoglobulin mu binding protein 2 [Homo sapiens]        32   2.5  
gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens]      31   4.3  
gi|39777586 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [Homo ...    30   5.7  
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member...    30   7.4  
gi|88942880 PREDICTED: hypothetical protein [Homo sapiens]             30   9.7  
gi|4503293 DEAH (Asp-Glu-Ala-His) box polypeptide 16 [Homo sapiens]    30   9.7  
gi|38158022 DEAH (Asp-Glu-Ala-His) box polypeptide 34 [Homo sapi...    30   9.7  

>gi|39725942 twinkle [Homo sapiens]
          Length = 684

 Score = 1388 bits (3593), Expect = 0.0
 Identities = 684/684 (100%), Positives = 684/684 (100%)

Query: 1   MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEI 60
           MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEI
Sbjct: 1   MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEI 60

Query: 61  RQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEG 120
           RQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEG
Sbjct: 61  RQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEG 120

Query: 121 SWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMF 180
           SWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMF
Sbjct: 121 SWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMF 180

Query: 181 GLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPR 240
           GLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPR
Sbjct: 181 GLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPR 240

Query: 241 PSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQ 300
           PSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQ
Sbjct: 241 PSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQ 300

Query: 301 FRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTAL 360
           FRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTAL
Sbjct: 301 FRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTAL 360

Query: 361 PAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSG 420
           PAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSG
Sbjct: 361 PAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSG 420

Query: 421 KTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFED 480
           KTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFED
Sbjct: 421 KTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFED 480

Query: 481 LPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIG 540
           LPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIG
Sbjct: 481 LPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIG 540

Query: 541 VFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGK 600
           VFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGK
Sbjct: 541 VFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGK 600

Query: 601 RYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGAT 660
           RYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGAT
Sbjct: 601 RYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGAT 660

Query: 661 TQNSEICSGQAPTPDQPDTSKRSK 684
           TQNSEICSGQAPTPDQPDTSKRSK
Sbjct: 661 TQNSEICSGQAPTPDQPDTSKRSK 684


>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
            sapiens]
          Length = 1480

 Score = 33.5 bits (75), Expect = 0.67
 Identities = 22/77 (28%), Positives = 34/77 (44%), Gaps = 7/77 (9%)

Query: 408  GELTVFTGPTGSGKTTFISEYALDLCSQGV----NTLWGSFEISNVRLARVMLTQ---FA 460
            G+     G TGSGK+T +S +   L ++G        W S  +   R A  ++ Q     
Sbjct: 1237 GQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIF 1296

Query: 461  EGRLEDQLDKYDHWADR 477
             G     LD Y+ W+D+
Sbjct: 1297 SGTFRKNLDPYEQWSDQ 1313


>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
           isoform 3 [Homo sapiens]
          Length = 1037

 Score = 33.5 bits (75), Expect = 0.67
 Identities = 39/140 (27%), Positives = 55/140 (39%), Gaps = 17/140 (12%)

Query: 379 GELSNVEQAAGLRWSRF-PDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLCSQGV 437
           G++ N      LR  RF P LN            V  GP G GKTT   +  LD     +
Sbjct: 141 GDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL 200

Query: 438 N-TLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLYFMTFHGQQSIRT 496
           + TL  +F +S   L+R+    FAE   +D       W +  +D+P         Q I  
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKD-------WPELQDDIPSILAQ---AQRILF 250

Query: 497 VIDTMQH-----AVYVYDIC 511
           V+D +          + DIC
Sbjct: 251 VVDGLDELKVPPGALIQDIC 270


>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
           2 [Homo sapiens]
          Length = 980

 Score = 33.5 bits (75), Expect = 0.67
 Identities = 39/140 (27%), Positives = 55/140 (39%), Gaps = 17/140 (12%)

Query: 379 GELSNVEQAAGLRWSRF-PDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLCSQGV 437
           G++ N      LR  RF P LN            V  GP G GKTT   +  LD     +
Sbjct: 141 GDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL 200

Query: 438 N-TLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLYFMTFHGQQSIRT 496
           + TL  +F +S   L+R+    FAE   +D       W +  +D+P         Q I  
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKD-------WPELQDDIPSILAQ---AQRILF 250

Query: 497 VIDTMQH-----AVYVYDIC 511
           V+D +          + DIC
Sbjct: 251 VVDGLDELKVPPGALIQDIC 270


>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
           1 [Homo sapiens]
          Length = 1009

 Score = 33.5 bits (75), Expect = 0.67
 Identities = 39/140 (27%), Positives = 55/140 (39%), Gaps = 17/140 (12%)

Query: 379 GELSNVEQAAGLRWSRF-PDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLCSQGV 437
           G++ N      LR  RF P LN            V  GP G GKTT   +  LD     +
Sbjct: 141 GDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL 200

Query: 438 N-TLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLYFMTFHGQQSIRT 496
           + TL  +F +S   L+R+    FAE   +D       W +  +D+P         Q I  
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKD-------WPELQDDIPSILAQ---AQRILF 250

Query: 497 VIDTMQH-----AVYVYDIC 511
           V+D +          + DIC
Sbjct: 251 VVDGLDELKVPPGALIQDIC 270


>gi|17149853 WAF-1/CIP1 stabilizing protein 39 [Homo sapiens]
          Length = 349

 Score = 32.7 bits (73), Expect = 1.1
 Identities = 26/89 (29%), Positives = 42/89 (47%), Gaps = 6/89 (6%)

Query: 43  ETLQALDMPVLPVTATEIRQYLRGHGIPFQDGHSCLRALS---PFAESSQLKGQTGVTTS 99
           E LQA D+   P  +   +  +RGHG+      SC R L+   PF  S   +G T +T  
Sbjct: 89  EALQASDLWYCPDGSFVKKIVIRGHGLDKPKLGSCCRVLALGFPFG-SGPPEGWTELTMG 147

Query: 100 FSLFIDKTTGHFL--CMTSLAEGSWEDFQ 126
              + ++T G  +  C+ S+ +G   + Q
Sbjct: 148 VGPWREETWGELIEKCLESMCQGEEAELQ 176


>gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]
          Length = 4024

 Score = 32.0 bits (71), Expect = 1.9
 Identities = 14/38 (36%), Positives = 25/38 (65%), Gaps = 2/38 (5%)

Query: 394  RFPDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALD 431
            R+  L  +L  H+K   ++F GPTG+GK+ +I+ + L+
Sbjct: 1957 RYSALMELLTTHQKP--SIFVGPTGTGKSVYITNFLLN 1992


>gi|38505213 YTH domain containing 2 [Homo sapiens]
          Length = 1430

 Score = 32.0 bits (71), Expect = 1.9
 Identities = 15/39 (38%), Positives = 23/39 (58%)

Query: 395 FPDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLC 433
           F     I+K  ++ ++ +  G TGSGKTT I ++ LD C
Sbjct: 196 FEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDC 234


>gi|119392094 immunoglobulin mu binding protein 2 [Homo sapiens]
          Length = 993

 Score = 31.6 bits (70), Expect = 2.5
 Identities = 14/32 (43%), Positives = 18/32 (56%)

Query: 409 ELTVFTGPTGSGKTTFISEYALDLCSQGVNTL 440
           EL +  GP G+GKTT + E  L    QG+  L
Sbjct: 208 ELAIIHGPPGTGKTTTVVEIILQAVKQGLKVL 239


>gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens]
          Length = 1844

 Score = 30.8 bits (68), Expect = 4.3
 Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 5/59 (8%)

Query: 412  VFTGPTGSGKTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDK 470
            + TGPTG GKT      A+  C+Q +         S+ R  R +L+Q  E     Q+DK
Sbjct: 1129 LITGPTGVGKTA-----AVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDK 1182


>gi|39777586 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [Homo
           sapiens]
          Length = 1386

 Score = 30.4 bits (67), Expect = 5.7
 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 15/80 (18%)

Query: 401 ILKGHRKGELTVFTGPTGSGKTTFISEYALD-------------LCSQ--GVNTLWGSFE 445
           IL   RK ++ V +G TG GKTT I ++ LD             +C+Q   ++ +  +  
Sbjct: 553 ILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAER 612

Query: 446 ISNVRLARVMLTQFAEGRLE 465
           ++  R  RV LT   + RLE
Sbjct: 613 VAKERAERVGLTVGYQIRLE 632


>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
           [Homo sapiens]
          Length = 1321

 Score = 30.0 bits (66), Expect = 7.4
 Identities = 13/27 (48%), Positives = 19/27 (70%), Gaps = 3/27 (11%)

Query: 397 DLNRILKGHRKGELTVFTGPTGSGKTT 423
           DLN ++K    GE+T   GP+G+GK+T
Sbjct: 440 DLNMVIK---PGEMTALVGPSGAGKST 463


>gi|88942880 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 120

 Score = 29.6 bits (65), Expect = 9.7
 Identities = 32/95 (33%), Positives = 41/95 (43%), Gaps = 15/95 (15%)

Query: 160 RAIPLWEL-----PDQEEVQLADTMFGLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGS 214
           R+ PL E      P  E  +LA+    L +  D + +   V    P RSL       GGS
Sbjct: 34  RSFPLVEAQAQAPPHGEARRLAEPALSLRQPIDASPRADPVP--APDRSL------SGGS 85

Query: 215 GLRGLKLLEAKCQGDGVSYEETTIPRPSAYHNLFG 249
              G  L     +  G + EETTIPRP  Y N +G
Sbjct: 86  AHSGRFLKPRLRRSSGETDEETTIPRP--YFNYYG 118


>gi|4503293 DEAH (Asp-Glu-Ala-His) box polypeptide 16 [Homo sapiens]
          Length = 1041

 Score = 29.6 bits (65), Expect = 9.7
 Identities = 29/124 (23%), Positives = 49/124 (39%), Gaps = 9/124 (7%)

Query: 309 GDDLRSWEAAKLFARKLNPKRCFLVRPG-DQQPRPLEALNGGFNLSRILRTALPAWHKSI 367
           G++ R WE A+L A  L     F  R    Q+P+    L     +  +  T L    +  
Sbjct: 323 GEEQRRWEEARLGAASLK----FGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPS 378

Query: 368 VSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSGKTTFISE 427
                 + +    +  V ++  +    FP    +L      ++ +  G TGSGKTT I +
Sbjct: 379 APPTSTQAQQKESIQAVRRSLPV----FPFREELLAAIANHQVLIIEGETGSGKTTQIPQ 434

Query: 428 YALD 431
           Y  +
Sbjct: 435 YLFE 438


>gi|38158022 DEAH (Asp-Glu-Ala-His) box polypeptide 34 [Homo
           sapiens]
          Length = 1143

 Score = 29.6 bits (65), Expect = 9.7
 Identities = 13/32 (40%), Positives = 21/32 (65%)

Query: 399 NRILKGHRKGELTVFTGPTGSGKTTFISEYAL 430
           NRIL+  ++ ++ V  G TG GK+T + +Y L
Sbjct: 169 NRILQTLKEHQVVVVAGDTGCGKSTQVPQYLL 200


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,384,652
Number of Sequences: 37866
Number of extensions: 1270501
Number of successful extensions: 3395
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3385
Number of HSP's gapped (non-prelim): 18
length of query: 684
length of database: 18,247,518
effective HSP length: 109
effective length of query: 575
effective length of database: 14,120,124
effective search space: 8119071300
effective search space used: 8119071300
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.