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Search of human proteins with 123701900
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
(1083 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|123701900 solute carrier family 12 (potassium/chloride transp... 2170 0.0
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 1586 0.0
gi|198041678 solute carrier family 12 (potassium-chloride transp... 1584 0.0
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 1514 0.0
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 1512 0.0
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 1512 0.0
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 1512 0.0
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 1512 0.0
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 1512 0.0
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 1506 0.0
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 1506 0.0
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 1503 0.0
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 1489 0.0
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 1473 0.0
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 238 3e-62
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 234 3e-61
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 234 3e-61
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 221 4e-57
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 208 3e-53
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 197 4e-50
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 102 3e-21
gi|33286430 solute carrier family 7 (cationic amino acid transpo... 45 3e-04
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 45 3e-04
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 40 0.012
gi|110347453 solute carrier family 7 (cationic amino acid transp... 37 0.13
gi|113722133 senataxin [Homo sapiens] 36 0.23
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 36 0.23
gi|114326550 solute carrier family 7 (cationic amino acid transp... 35 0.29
gi|114326544 solute carrier family 7 (cationic amino acid transp... 35 0.29
gi|181337167 solute carrier family 7 (cationic amino acid transp... 35 0.29
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 2170 bits (5622), Expect = 0.0
Identities = 1083/1083 (100%), Positives = 1083/1083 (100%)
Query: 1 MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQ 60
MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQ
Sbjct: 1 MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQ 60
Query: 61 ESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRMGT 120
ESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRMGT
Sbjct: 61 ESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRMGT 120
Query: 121 FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVV 180
FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVV
Sbjct: 121 FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVV 180
Query: 181 PAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAA 240
PAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAA
Sbjct: 181 PAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAA 240
Query: 241 GGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAF 300
GGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAF
Sbjct: 241 GGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAF 300
Query: 301 DPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNN 360
DPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNN
Sbjct: 301 DPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNN 360
Query: 361 VTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASF 420
VTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASF
Sbjct: 361 VTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASF 420
Query: 421 TLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGV 480
TLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGV
Sbjct: 421 TLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGV 480
Query: 481 VLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVP 540
VLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVP
Sbjct: 481 VLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVP 540
Query: 541 FLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQT 600
FLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQT
Sbjct: 541 FLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQT 600
Query: 601 LLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKE 660
LLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKE
Sbjct: 601 LLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKE 660
Query: 661 WGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKA 720
WGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKA
Sbjct: 661 WGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKA 720
Query: 721 GKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQS 780
GKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQS
Sbjct: 721 GKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQS 780
Query: 781 AGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQER 840
AGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQER
Sbjct: 781 AGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQER 840
Query: 841 FGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLY 900
FGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLY
Sbjct: 841 FGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLY 900
Query: 901 HLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTAS 960
HLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTAS
Sbjct: 901 HLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTAS 960
Query: 961 HTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTA 1020
HTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTA
Sbjct: 961 HTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTA 1020
Query: 1021 VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT 1080
VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT
Sbjct: 1021 VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT 1080
Query: 1081 IYS 1083
IYS
Sbjct: 1081 IYS 1083
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 1586 bits (4107), Expect = 0.0
Identities = 792/1101 (71%), Positives = 906/1101 (82%), Gaps = 57/1101 (5%)
Query: 40 SPGDGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGV 99
+PGDGNP+E+SPF+N+ + E+ ++GKNMALFEEEMD++PMVSSLL+ LANYTNL QG
Sbjct: 16 NPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGS 75
Query: 100 VEHEEDEES---RRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLI 156
EHEE E + +++ +APRMGTF+GVYLPCLQNI GVILFLRLTW+VG+AG++ESF +
Sbjct: 76 REHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCM 135
Query: 157 VAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY 216
V +CC+CTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY
Sbjct: 136 VFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY 195
Query: 217 ILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKL 276
ILGTIEI L Y+ P AIF+AE A GEAAAML+NMRVYGTC L MA VVFVGVKYVNK
Sbjct: 196 ILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKF 255
Query: 277 ALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATS 336
ALVFL CV+LSILAIYAGVIKSAFDPP+ P+CLLGNRTLSR FD C K N + T+
Sbjct: 256 ALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTT 315
Query: 337 ALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVP 396
LWGLFC+ +A CDEYF +NNVTEIQGIPGAASG+ ENLWS+Y G VE+ G+
Sbjct: 316 RLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMT 375
Query: 397 SVPVAEESRASA-LPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGT 455
SV +A+ + PYV +D+ + FTLLVGIYFPSVTGIMAGSNRSGDL+DAQKSIPTGT
Sbjct: 376 SVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGT 435
Query: 456 ILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFST 515
ILAI TTS +Y+S +VLFGACIEGVVLRDKFGEA+ GNLV+G LAWPSPWVIVIGSFFST
Sbjct: 436 ILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFST 495
Query: 516 CGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLD 575
CGAGLQSLTGAPRLLQAI+RDGIVPFLQVFGHGKANGEPTWALLLT ICE GILIASLD
Sbjct: 496 CGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLD 555
Query: 576 SVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSW 635
VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF++YHWTLSFLGMSLCLALMFICSW
Sbjct: 556 EVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSW 615
Query: 636 YYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVL 695
YYAL AMLIAG IYKYIEYRGAEKEWGDGIRGLSL+AARYALLR+E GPPHTKNWRPQ+L
Sbjct: 616 YYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 675
Query: 696 VMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMST 755
V++ +D +Q V HP+LLS TSQLKAGKGLTIVGSVLEGT+L+ H +AQRAEE+IR LM
Sbjct: 676 VLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEA 735
Query: 756 EKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTV 815
EK KGFCQ+V+SS+LRDG+SHLIQS GLGGL+HNTVL+ WP +W+Q+++ +W+NF++ V
Sbjct: 736 EKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELV 795
Query: 816 RDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCR 875
R+TTA H ALLV KNV FP N ERF G IDVWWIVHDGGMLMLLPFLLR HKVWRKC+
Sbjct: 796 RETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 855
Query: 876 MRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQM 935
MRIFTVAQ+DDNSIQMKKDL FLYHLRI+AEVEVVEM E+DISA+TYE+TL+MEQRSQ+
Sbjct: 856 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQI 915
Query: 936 LKQMQLSKNEQER-----------------------------------------EAQLIH 954
LKQM L+KNE+ER E QLIH
Sbjct: 916 LKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 975
Query: 955 DRNTASHTAAAARTQAPP------TPDKVQMTWTREKLIAEKYRS-RDTSLSGFKDLFSM 1007
D++ S +++ P P+KV +TWT++K +AEK + S G KD FSM
Sbjct: 976 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSM 1035
Query: 1008 KPD-----QSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLT 1062
KP+ QSNVRRMHTAV+LN V++ KS+DA+LVLLNMPGPP+NR GDENYMEFLEVLT
Sbjct: 1036 KPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLT 1095
Query: 1063 EGLNRVLLVRGGGREVITIYS 1083
E L+RV+LVRGGGREVITIYS
Sbjct: 1096 EHLDRVMLVRGGGREVITIYS 1116
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 1584 bits (4102), Expect = 0.0
Identities = 798/1140 (70%), Positives = 914/1140 (80%), Gaps = 58/1140 (5%)
Query: 1 MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQ 60
M FTV + + R + P P GDGNP+E+SPF+N+ + E+
Sbjct: 1 MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHL-PGEDVKGDGNPKESSPFINSTDTEK 59
Query: 61 ESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEES---RRREAKAPR 117
++GKNMALFEEEMD++PMVSSLL+ LANYTNL QG EHEE E + +++ +APR
Sbjct: 60 GKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPR 119
Query: 118 MGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATN 177
MGTF+GVYLPCLQNI GVILFLRLTW+VG+AG++ESF +V +CC+CTMLTAISMSAIATN
Sbjct: 120 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 179
Query: 178 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQA 237
GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEI L Y+ P AIF+A
Sbjct: 180 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 239
Query: 238 EAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIK 297
E A GEAAAML+NMRVYGTC L MA VVFVGVKYVNK ALVFL CV+LSILAIYAGVIK
Sbjct: 240 EDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIK 299
Query: 298 SAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFI 357
SAFDPP+ P+CLLGNRTLSR FD C K N + T+ LWGLFC+ +A CDEYF
Sbjct: 300 SAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFT 359
Query: 358 QNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASA-LPYVLTDI 416
+NNVTEIQGIPGAASG+ ENLWS+Y G VE+ G+ SV +A+ + PYV +D+
Sbjct: 360 RNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDM 419
Query: 417 AASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGAC 476
+ FTLLVGIYFPSVTGIMAGSNRSGDL+DAQKSIPTGTILAI TTS +Y+S +VLFGAC
Sbjct: 420 TSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGAC 479
Query: 477 IEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARD 536
IEGVVLRDKFGEA+ GNLV+G LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI+RD
Sbjct: 480 IEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRD 539
Query: 537 GIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLAC 596
GIVPFLQVFGHGKANGEPTWALLLT ICE GILIASLD VAPILSMFFLMCY+FVNLAC
Sbjct: 540 GIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLAC 599
Query: 597 AVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRG 656
AVQTLLRTPNWRPRF++YHWTLSFLGMSLCLALMFICSWYYAL AMLIAG IYKYIEYRG
Sbjct: 600 AVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRG 659
Query: 657 AEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTS 716
AEKEWGDGIRGLSL+AARYALLR+E GPPHTKNWRPQ+LV++ +D +Q V HP+LLS TS
Sbjct: 660 AEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTS 719
Query: 717 QLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSH 776
QLKAGKGLTIVGSVLEGT+L+ H +AQRAEE+IR LM EK KGFCQ+V+SS+LRDG+SH
Sbjct: 720 QLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSH 779
Query: 777 LIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQ 836
LIQS GLGGL+HNTVL+ WP +W+Q+++ +W+NF++ VR+TTA H ALLV KNV FP
Sbjct: 780 LIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPG 839
Query: 837 NQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQ 896
N ERF G IDVWWIVHDGGMLMLLPFLLR HKVWRKC+MRIFTVAQ+DDNSIQMKKDL
Sbjct: 840 NPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLT 899
Query: 897 MFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQER-------- 948
FLYHLRI+AEVEVVEM E+DISA+TYE+TL+MEQRSQ+LKQM L+KNE+ER
Sbjct: 900 TFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDE 959
Query: 949 ---------------------------------EAQLIHDRNTASHTAAAARTQAPP--- 972
E QLIHD++ S +++ P
Sbjct: 960 SRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGE 1019
Query: 973 ---TPDKVQMTWTREKLIAEKYRS-RDTSLSGFKDLFSMKPD-----QSNVRRMHTAVKL 1023
P+KV +TWT++K +AEK + S G KD FSMKP+ QSNVRRMHTAV+L
Sbjct: 1020 GETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRL 1079
Query: 1024 NGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1083
N V++ KS+DA+LVLLNMPGPP+NR GDENYMEFLEVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1080 NEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 1514 bits (3919), Expect = 0.0
Identities = 756/1082 (69%), Positives = 881/1082 (81%), Gaps = 13/1082 (1%)
Query: 11 EAHADGGGDETAERTEA--PGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQESFFEGKN 68
E ++ G T+ T A P + P+ DG+ + + +LNN E+ + KN
Sbjct: 58 EPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDDGHKKARNAYLNNSNYEEGDEYFDKN 117
Query: 69 MALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDE---ESRRREAKAPRMGTFIGVY 125
+ALFEEEMD+ P VSSLLN++ANYTNL+QG EHEE E E +++ K P+MGTF+GVY
Sbjct: 118 LALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVY 177
Query: 126 LPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGS 185
LPCLQNI GVILFLRLTW+VG AGVL++F IV +CC CTMLTAISMSAIATNGVVPAGGS
Sbjct: 178 LPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGS 237
Query: 186 YYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAA 245
Y+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG IEIFL YI P AAIF ++ A E+A
Sbjct: 238 YFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESA 297
Query: 246 AMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDI 305
AML+NMRVYGT LVLM LVVF+GV+YVNK A +FLACV++SILAIYAG IKS+F PP
Sbjct: 298 AMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHF 357
Query: 306 PVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQP-SAACDEYFIQNNVTEI 364
PVC+LGNRTLS R D C K I+N + S LWG FCN SQ +A CDEYF+ NNVT I
Sbjct: 358 PVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSI 417
Query: 365 QGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASFTLLV 424
QGIPG ASG+ ENLWS Y G +EK PS ++ + YVL DI SFTLLV
Sbjct: 418 QGIPGLASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLV 474
Query: 425 GIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRD 484
GI+FPSVTGIMAGSNRSGDLKDAQKSIP GTILAI+TTSF+YLS +VLFGACIEGVVLRD
Sbjct: 475 GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 534
Query: 485 KFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQV 544
KFG+A++GNLV+G L+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA+D I+PFL+V
Sbjct: 535 KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 594
Query: 545 FGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRT 604
FGH KANGEPTWALLLT I E GILIASLD VAPILSMFFLMCYLFVNLACA+QTLLRT
Sbjct: 595 FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 654
Query: 605 PNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDG 664
PNWRPRF++YHW LSF+GMS+CLALMFI SWYYA+ AM+IAG IYKYIEY+GAEKEWGDG
Sbjct: 655 PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 714
Query: 665 IRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGL 724
IRGLSL+AAR+ALLR+E GPPHTKNWRPQ+LV+L LD + VKHPRLL+F SQLKAGKGL
Sbjct: 715 IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 774
Query: 725 TIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLG 784
TIVGSV+ G +L+ + EA AE+ I+ LM EK KGFCQLVV++ LR+G+SHLIQS GLG
Sbjct: 775 TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 834
Query: 785 GLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGG 844
G+KHNTV+M WP W+Q ++ +WK F+ TVR TTAAH ALLVAKN+ FP N E+F G
Sbjct: 835 GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 894
Query: 845 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRI 904
+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDL FLYHLRI
Sbjct: 895 NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 954
Query: 905 SAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAA 964
AEVEVVEM ++DISA+TYERTLMMEQRSQML+ M+LSK E++REAQL+ DRN+ +
Sbjct: 955 EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1014
Query: 965 AARTQAPPT---PDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAV 1021
+ T +KV MTWT++K +A + + S+ GF+DL +M+PDQSNVRRMHTAV
Sbjct: 1015 IGSDEDEETETYQEKVHMTWTKDKYMASR-GQKAKSMEGFQDLLNMRPDQSNVRRMHTAV 1073
Query: 1022 KLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITI 1081
KLN V++NKS +A+LVLLNMPGPP+N +GDENYMEFLEVLTEGL RVLLVRGGG EVITI
Sbjct: 1074 KLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITI 1133
Query: 1082 YS 1083
YS
Sbjct: 1134 YS 1135
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 1512 bits (3915), Expect = 0.0
Identities = 749/1048 (71%), Positives = 869/1048 (82%), Gaps = 11/1048 (1%)
Query: 43 DGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH 102
DG+ + + +LNN E+ + KN+ALFEEEMD+ P VSSLLN++ANYTNL+QG EH
Sbjct: 98 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 157
Query: 103 EEDE---ESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAM 159
EE E E +++ K P+MGTF+GVYLPCLQNI GVILFLRLTW+VG AGVL++F IV +
Sbjct: 158 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 217
Query: 160 CCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 219
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 218 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 277
Query: 220 TIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALV 279
IEIFL YI P AAIF ++ A E+AAML+NMRVYGT LVLM LVVF+GV+YVNK A +
Sbjct: 278 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 337
Query: 280 FLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALW 339
FLACV++SILAIYAG IKS+F PP PVC+LGNRTLS R D C K I+N + S LW
Sbjct: 338 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 397
Query: 340 GLFCNGSQP-SAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV 398
G FCN SQ +A CDEYF+ NNVT IQGIPG ASG+ ENLWS Y G +EK PS
Sbjct: 398 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSA 454
Query: 399 PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILA 458
++ + YVL DI SFTLLVGI+FPSVTGIMAGSNRSGDLKDAQKSIP GTILA
Sbjct: 455 KSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILA 514
Query: 459 IVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGA 518
I+TTSF+YLS +VLFGACIEGVVLRDKFG+A++GNLV+G L+WPSPWVIVIGSFFSTCGA
Sbjct: 515 ILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGA 574
Query: 519 GLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA 578
GLQSLTGAPRLLQAIA+D I+PFL+VFGH KANGEPTWALLLT I E GILIASLD VA
Sbjct: 575 GLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVA 634
Query: 579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYA 638
PILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF++YHW LSF+GMS+CLALMFI SWYYA
Sbjct: 635 PILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYA 694
Query: 639 LSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVML 698
+ AM+IAG IYKYIEY+GAEKEWGDGIRGLSL+AAR+ALLR+E GPPHTKNWRPQ+LV+L
Sbjct: 695 IVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLL 754
Query: 699 NLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT 758
LD + VKHPRLL+F SQLKAGKGLTIVGSV+ G +L+ + EA AE+ I+ LM EK
Sbjct: 755 KLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKV 814
Query: 759 KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDT 818
KGFCQLVV++ LR+G+SHLIQS GLGG+KHNTV+M WP W+Q ++ +WK F+ TVR T
Sbjct: 815 KGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 874
Query: 819 TAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
TAAH ALLVAKN+ FP N E+F G+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RI
Sbjct: 875 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 934
Query: 879 FTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ 938
FTVAQ++DNSIQMKKDL FLYHLRI AEVEVVEM ++DISA+TYERTLMMEQRSQML+
Sbjct: 935 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 994
Query: 939 MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPT---PDKVQMTWTREKLIAEKYRSRD 995
M+LSK E++REAQL+ DRN+ + + T +KV MTWT++K +A + +
Sbjct: 995 MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR-GQKA 1053
Query: 996 TSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYM 1055
S+ GF+DL +M+PDQSNVRRMHTAVKLN V++NKS +A+LVLLNMPGPP+N +GDENYM
Sbjct: 1054 KSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYM 1113
Query: 1056 EFLEVLTEGLNRVLLVRGGGREVITIYS 1083
EFLEVLTEGL RVLLVRGGG EVITIYS
Sbjct: 1114 EFLEVLTEGLERVLLVRGGGSEVITIYS 1141
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1512 bits (3915), Expect = 0.0
Identities = 749/1048 (71%), Positives = 869/1048 (82%), Gaps = 11/1048 (1%)
Query: 43 DGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH 102
DG+ + + +LNN E+ + KN+ALFEEEMD+ P VSSLLN++ANYTNL+QG EH
Sbjct: 48 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 107
Query: 103 EEDE---ESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAM 159
EE E E +++ K P+MGTF+GVYLPCLQNI GVILFLRLTW+VG AGVL++F IV +
Sbjct: 108 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 167
Query: 160 CCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 219
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 168 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 227
Query: 220 TIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALV 279
IEIFL YI P AAIF ++ A E+AAML+NMRVYGT LVLM LVVF+GV+YVNK A +
Sbjct: 228 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 287
Query: 280 FLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALW 339
FLACV++SILAIYAG IKS+F PP PVC+LGNRTLS R D C K I+N + S LW
Sbjct: 288 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 347
Query: 340 GLFCNGSQP-SAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV 398
G FCN SQ +A CDEYF+ NNVT IQGIPG ASG+ ENLWS Y G +EK PS
Sbjct: 348 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSA 404
Query: 399 PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILA 458
++ + YVL DI SFTLLVGI+FPSVTGIMAGSNRSGDLKDAQKSIP GTILA
Sbjct: 405 KSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILA 464
Query: 459 IVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGA 518
I+TTSF+YLS +VLFGACIEGVVLRDKFG+A++GNLV+G L+WPSPWVIVIGSFFSTCGA
Sbjct: 465 ILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGA 524
Query: 519 GLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA 578
GLQSLTGAPRLLQAIA+D I+PFL+VFGH KANGEPTWALLLT I E GILIASLD VA
Sbjct: 525 GLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVA 584
Query: 579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYA 638
PILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF++YHW LSF+GMS+CLALMFI SWYYA
Sbjct: 585 PILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYA 644
Query: 639 LSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVML 698
+ AM+IAG IYKYIEY+GAEKEWGDGIRGLSL+AAR+ALLR+E GPPHTKNWRPQ+LV+L
Sbjct: 645 IVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLL 704
Query: 699 NLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT 758
LD + VKHPRLL+F SQLKAGKGLTIVGSV+ G +L+ + EA AE+ I+ LM EK
Sbjct: 705 KLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKV 764
Query: 759 KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDT 818
KGFCQLVV++ LR+G+SHLIQS GLGG+KHNTV+M WP W+Q ++ +WK F+ TVR T
Sbjct: 765 KGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 824
Query: 819 TAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
TAAH ALLVAKN+ FP N E+F G+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RI
Sbjct: 825 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 884
Query: 879 FTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ 938
FTVAQ++DNSIQMKKDL FLYHLRI AEVEVVEM ++DISA+TYERTLMMEQRSQML+
Sbjct: 885 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 944
Query: 939 MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPT---PDKVQMTWTREKLIAEKYRSRD 995
M+LSK E++REAQL+ DRN+ + + T +KV MTWT++K +A + +
Sbjct: 945 MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR-GQKA 1003
Query: 996 TSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYM 1055
S+ GF+DL +M+PDQSNVRRMHTAVKLN V++NKS +A+LVLLNMPGPP+N +GDENYM
Sbjct: 1004 KSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYM 1063
Query: 1056 EFLEVLTEGLNRVLLVRGGGREVITIYS 1083
EFLEVLTEGL RVLLVRGGG EVITIYS
Sbjct: 1064 EFLEVLTEGLERVLLVRGGGSEVITIYS 1091
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1512 bits (3915), Expect = 0.0
Identities = 749/1048 (71%), Positives = 869/1048 (82%), Gaps = 11/1048 (1%)
Query: 43 DGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH 102
DG+ + + +LNN E+ + KN+ALFEEEMD+ P VSSLLN++ANYTNL+QG EH
Sbjct: 48 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 107
Query: 103 EEDE---ESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAM 159
EE E E +++ K P+MGTF+GVYLPCLQNI GVILFLRLTW+VG AGVL++F IV +
Sbjct: 108 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 167
Query: 160 CCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 219
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 168 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 227
Query: 220 TIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALV 279
IEIFL YI P AAIF ++ A E+AAML+NMRVYGT LVLM LVVF+GV+YVNK A +
Sbjct: 228 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 287
Query: 280 FLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALW 339
FLACV++SILAIYAG IKS+F PP PVC+LGNRTLS R D C K I+N + S LW
Sbjct: 288 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 347
Query: 340 GLFCNGSQP-SAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV 398
G FCN SQ +A CDEYF+ NNVT IQGIPG ASG+ ENLWS Y G +EK PS
Sbjct: 348 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSA 404
Query: 399 PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILA 458
++ + YVL DI SFTLLVGI+FPSVTGIMAGSNRSGDLKDAQKSIP GTILA
Sbjct: 405 KSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILA 464
Query: 459 IVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGA 518
I+TTSF+YLS +VLFGACIEGVVLRDKFG+A++GNLV+G L+WPSPWVIVIGSFFSTCGA
Sbjct: 465 ILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGA 524
Query: 519 GLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA 578
GLQSLTGAPRLLQAIA+D I+PFL+VFGH KANGEPTWALLLT I E GILIASLD VA
Sbjct: 525 GLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVA 584
Query: 579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYA 638
PILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF++YHW LSF+GMS+CLALMFI SWYYA
Sbjct: 585 PILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYA 644
Query: 639 LSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVML 698
+ AM+IAG IYKYIEY+GAEKEWGDGIRGLSL+AAR+ALLR+E GPPHTKNWRPQ+LV+L
Sbjct: 645 IVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLL 704
Query: 699 NLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT 758
LD + VKHPRLL+F SQLKAGKGLTIVGSV+ G +L+ + EA AE+ I+ LM EK
Sbjct: 705 KLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKV 764
Query: 759 KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDT 818
KGFCQLVV++ LR+G+SHLIQS GLGG+KHNTV+M WP W+Q ++ +WK F+ TVR T
Sbjct: 765 KGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 824
Query: 819 TAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
TAAH ALLVAKN+ FP N E+F G+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RI
Sbjct: 825 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 884
Query: 879 FTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ 938
FTVAQ++DNSIQMKKDL FLYHLRI AEVEVVEM ++DISA+TYERTLMMEQRSQML+
Sbjct: 885 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 944
Query: 939 MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPT---PDKVQMTWTREKLIAEKYRSRD 995
M+LSK E++REAQL+ DRN+ + + T +KV MTWT++K +A + +
Sbjct: 945 MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR-GQKA 1003
Query: 996 TSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYM 1055
S+ GF+DL +M+PDQSNVRRMHTAVKLN V++NKS +A+LVLLNMPGPP+N +GDENYM
Sbjct: 1004 KSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYM 1063
Query: 1056 EFLEVLTEGLNRVLLVRGGGREVITIYS 1083
EFLEVLTEGL RVLLVRGGG EVITIYS
Sbjct: 1064 EFLEVLTEGLERVLLVRGGGSEVITIYS 1091
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 1512 bits (3915), Expect = 0.0
Identities = 749/1048 (71%), Positives = 869/1048 (82%), Gaps = 11/1048 (1%)
Query: 43 DGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH 102
DG+ + + +LNN E+ + KN+ALFEEEMD+ P VSSLLN++ANYTNL+QG EH
Sbjct: 56 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 115
Query: 103 EEDE---ESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAM 159
EE E E +++ K P+MGTF+GVYLPCLQNI GVILFLRLTW+VG AGVL++F IV +
Sbjct: 116 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 175
Query: 160 CCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 219
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 176 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 235
Query: 220 TIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALV 279
IEIFL YI P AAIF ++ A E+AAML+NMRVYGT LVLM LVVF+GV+YVNK A +
Sbjct: 236 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 295
Query: 280 FLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALW 339
FLACV++SILAIYAG IKS+F PP PVC+LGNRTLS R D C K I+N + S LW
Sbjct: 296 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 355
Query: 340 GLFCNGSQP-SAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV 398
G FCN SQ +A CDEYF+ NNVT IQGIPG ASG+ ENLWS Y G +EK PS
Sbjct: 356 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSA 412
Query: 399 PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILA 458
++ + YVL DI SFTLLVGI+FPSVTGIMAGSNRSGDLKDAQKSIP GTILA
Sbjct: 413 KSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILA 472
Query: 459 IVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGA 518
I+TTSF+YLS +VLFGACIEGVVLRDKFG+A++GNLV+G L+WPSPWVIVIGSFFSTCGA
Sbjct: 473 ILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGA 532
Query: 519 GLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA 578
GLQSLTGAPRLLQAIA+D I+PFL+VFGH KANGEPTWALLLT I E GILIASLD VA
Sbjct: 533 GLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVA 592
Query: 579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYA 638
PILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF++YHW LSF+GMS+CLALMFI SWYYA
Sbjct: 593 PILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYA 652
Query: 639 LSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVML 698
+ AM+IAG IYKYIEY+GAEKEWGDGIRGLSL+AAR+ALLR+E GPPHTKNWRPQ+LV+L
Sbjct: 653 IVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLL 712
Query: 699 NLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT 758
LD + VKHPRLL+F SQLKAGKGLTIVGSV+ G +L+ + EA AE+ I+ LM EK
Sbjct: 713 KLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKV 772
Query: 759 KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDT 818
KGFCQLVV++ LR+G+SHLIQS GLGG+KHNTV+M WP W+Q ++ +WK F+ TVR T
Sbjct: 773 KGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 832
Query: 819 TAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
TAAH ALLVAKN+ FP N E+F G+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RI
Sbjct: 833 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 892
Query: 879 FTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ 938
FTVAQ++DNSIQMKKDL FLYHLRI AEVEVVEM ++DISA+TYERTLMMEQRSQML+
Sbjct: 893 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 952
Query: 939 MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPT---PDKVQMTWTREKLIAEKYRSRD 995
M+LSK E++REAQL+ DRN+ + + T +KV MTWT++K +A + +
Sbjct: 953 MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR-GQKA 1011
Query: 996 TSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYM 1055
S+ GF+DL +M+PDQSNVRRMHTAVKLN V++NKS +A+LVLLNMPGPP+N +GDENYM
Sbjct: 1012 KSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYM 1071
Query: 1056 EFLEVLTEGLNRVLLVRGGGREVITIYS 1083
EFLEVLTEGL RVLLVRGGG EVITIYS
Sbjct: 1072 EFLEVLTEGLERVLLVRGGGSEVITIYS 1099
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 1512 bits (3915), Expect = 0.0
Identities = 749/1048 (71%), Positives = 869/1048 (82%), Gaps = 11/1048 (1%)
Query: 43 DGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH 102
DG+ + + +LNN E+ + KN+ALFEEEMD+ P VSSLLN++ANYTNL+QG EH
Sbjct: 107 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 166
Query: 103 EEDE---ESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAM 159
EE E E +++ K P+MGTF+GVYLPCLQNI GVILFLRLTW+VG AGVL++F IV +
Sbjct: 167 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 226
Query: 160 CCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 219
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 227 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 286
Query: 220 TIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALV 279
IEIFL YI P AAIF ++ A E+AAML+NMRVYGT LVLM LVVF+GV+YVNK A +
Sbjct: 287 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 346
Query: 280 FLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALW 339
FLACV++SILAIYAG IKS+F PP PVC+LGNRTLS R D C K I+N + S LW
Sbjct: 347 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 406
Query: 340 GLFCNGSQP-SAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV 398
G FCN SQ +A CDEYF+ NNVT IQGIPG ASG+ ENLWS Y G +EK PS
Sbjct: 407 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSA 463
Query: 399 PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILA 458
++ + YVL DI SFTLLVGI+FPSVTGIMAGSNRSGDLKDAQKSIP GTILA
Sbjct: 464 KSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILA 523
Query: 459 IVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGA 518
I+TTSF+YLS +VLFGACIEGVVLRDKFG+A++GNLV+G L+WPSPWVIVIGSFFSTCGA
Sbjct: 524 ILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGA 583
Query: 519 GLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA 578
GLQSLTGAPRLLQAIA+D I+PFL+VFGH KANGEPTWALLLT I E GILIASLD VA
Sbjct: 584 GLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVA 643
Query: 579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYA 638
PILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF++YHW LSF+GMS+CLALMFI SWYYA
Sbjct: 644 PILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYA 703
Query: 639 LSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVML 698
+ AM+IAG IYKYIEY+GAEKEWGDGIRGLSL+AAR+ALLR+E GPPHTKNWRPQ+LV+L
Sbjct: 704 IVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLL 763
Query: 699 NLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT 758
LD + VKHPRLL+F SQLKAGKGLTIVGSV+ G +L+ + EA AE+ I+ LM EK
Sbjct: 764 KLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKV 823
Query: 759 KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDT 818
KGFCQLVV++ LR+G+SHLIQS GLGG+KHNTV+M WP W+Q ++ +WK F+ TVR T
Sbjct: 824 KGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 883
Query: 819 TAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
TAAH ALLVAKN+ FP N E+F G+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RI
Sbjct: 884 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 943
Query: 879 FTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ 938
FTVAQ++DNSIQMKKDL FLYHLRI AEVEVVEM ++DISA+TYERTLMMEQRSQML+
Sbjct: 944 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 1003
Query: 939 MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPT---PDKVQMTWTREKLIAEKYRSRD 995
M+LSK E++REAQL+ DRN+ + + T +KV MTWT++K +A + +
Sbjct: 1004 MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR-GQKA 1062
Query: 996 TSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYM 1055
S+ GF+DL +M+PDQSNVRRMHTAVKLN V++NKS +A+LVLLNMPGPP+N +GDENYM
Sbjct: 1063 KSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYM 1122
Query: 1056 EFLEVLTEGLNRVLLVRGGGREVITIYS 1083
EFLEVLTEGL RVLLVRGGG EVITIYS
Sbjct: 1123 EFLEVLTEGLERVLLVRGGGSEVITIYS 1150
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 1506 bits (3900), Expect = 0.0
Identities = 748/1052 (71%), Positives = 867/1052 (82%), Gaps = 11/1052 (1%)
Query: 40 SPGDGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGV 99
SPG GN RE+SPFL+ +E + + +N+ALFEEE+D P VSSLL KL +YTNL+QG
Sbjct: 6 SPGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGA 65
Query: 100 VEHEEDEE---SRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLI 156
EHEE E +RRR A+AP MGT +GVYLPCLQNI GVILFLRLTW+VG AGVL++ LI
Sbjct: 66 KEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLI 125
Query: 157 VAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY 216
V +CC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMY
Sbjct: 126 VLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMY 185
Query: 217 ILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKL 276
ILG IEI LTYI+P AAIF A + A L+NMRVYGT L M LVVFVGVKYVNK
Sbjct: 186 ILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 245
Query: 277 ALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATS 336
A +FLACV++SIL+IYAG IKS FDPP PVC+LGNRTLSR FD C K + N + +
Sbjct: 246 ASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVAT 305
Query: 337 ALWGLFCNGSQPSA-ACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGV 395
LW FC+ + +CD YF+ NNVTEI GIPGAA+GV ENLWS Y G VEK G+
Sbjct: 306 QLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGL 365
Query: 396 PSVPVAEESRASALP-YVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTG 454
PS S +LP YV+ DIA SFT+LVGI+FPSVTGIMAGSNRSGDL+DAQKSIP G
Sbjct: 366 PSADAP--SLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVG 423
Query: 455 TILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFS 514
TILAI+TTS +Y S +VLFGACIEGVVLRDK+G+ + NLV+G LAWPSPWVIVIGSFFS
Sbjct: 424 TILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFS 483
Query: 515 TCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASL 574
TCGAGLQSLTGAPRLLQAIA+D I+PFL+VFGHGK NGEPTWALLLT LI E GILIASL
Sbjct: 484 TCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASL 543
Query: 575 DSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICS 634
D VAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFK+YHW LSFLGMSLCLALMF+ S
Sbjct: 544 DMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSS 603
Query: 635 WYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQV 694
WYYAL AMLIAG IYKYIEY+GAEKEWGDGIRGLSL+AARYALLR+E GPPHTKNWRPQ+
Sbjct: 604 WYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQL 663
Query: 695 LVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMS 754
LV+L LD + VK+PRLL+F SQLKAGKGLTIVGSV++G++L+ + EAQ AE+ I+++M
Sbjct: 664 LVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMME 723
Query: 755 TEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDT 814
EK KGFCQ+VV+S +R+G++HLIQS GLGG++HN+V++ WP W+Q ++P +WK F+DT
Sbjct: 724 IEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDT 783
Query: 815 VRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKC 874
VR TTAAH ALLV KN+ +P N ER+ GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKC
Sbjct: 784 VRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKC 843
Query: 875 RMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQ 934
RMRIFTVAQ+DDNSIQMKKDL +FLYHLR+ AEVEVVEM +DISA+TYERTLMMEQRSQ
Sbjct: 844 RMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQ 903
Query: 935 MLKQMQLSKNEQEREAQLIHDRNTASHTAAA---ARTQAPPTPDKVQMTWTREKLIAEKY 991
ML+QM+L+K E+EREAQL+ DR++A + ++ DK+QMTWTR+K + E +
Sbjct: 904 MLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETW 963
Query: 992 RSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGD 1051
+ F++L +KPDQSNVRRMHTAVKLN V++ +S DA+LVLLNMPGPP+N +GD
Sbjct: 964 -DPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGD 1022
Query: 1052 ENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1083
ENYMEFLEVLTEGL RVLLVRGGGREVITIYS
Sbjct: 1023 ENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1054
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 1506 bits (3900), Expect = 0.0
Identities = 758/1088 (69%), Positives = 880/1088 (80%), Gaps = 13/1088 (1%)
Query: 4 NFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQESF 63
+FTVVPV+ G D E E E + S G GN RE+SPFL+ +E +
Sbjct: 3 HFTVVPVDGPRRGDYDNL-EGLSWVDYGERAELD-DSDGHGNHRESSPFLSPLEASRGID 60
Query: 64 FEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEE---SRRREAKAPRMGT 120
+ +N+ALFEEE+D P VSSLL KL +YTNL+QG EHEE E +RRR A+AP MGT
Sbjct: 61 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 120
Query: 121 FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVV 180
+GVYLPCLQNI GVILFLRLTW+VG AGVL++ LIV +CC CT+LTAISMSAIATNGVV
Sbjct: 121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 180
Query: 181 PAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAA 240
PAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYILG IEI LTYI+P AAIF A
Sbjct: 181 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 240
Query: 241 GGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAF 300
+ A L+NMRVYGT L M LVVFVGVKYVNK A +FLACV++SIL+IYAG IKS F
Sbjct: 241 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 300
Query: 301 DPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSA-ACDEYFIQN 359
DPP PVC+LGNRTLSR FD C K + N + + LW FC+ + +CD YF+ N
Sbjct: 301 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 360
Query: 360 NVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALP-YVLTDIAA 418
NVTEI GIPGAA+GV ENLWS Y G VEK G+PS S +LP YV+ DIA
Sbjct: 361 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAP--SLKESLPLYVVADIAT 418
Query: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
SFT+LVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTILAI+TTS +Y S +VLFGACIE
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 479 GVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGI 538
GVVLRDK+G+ + NLV+G LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA+D I
Sbjct: 479 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 538
Query: 539 VPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAV 598
+PFL+VFGHGK NGEPTWALLLT LI E GILIASLD VAPILSMFFLMCYLFVNLACAV
Sbjct: 539 IPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAV 598
Query: 599 QTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAE 658
QTLLRTPNWRPRFK+YHW LSFLGMSLCLALMF+ SWYYAL AMLIAG IYKYIEY+GAE
Sbjct: 599 QTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 658
Query: 659 KEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQL 718
KEWGDGIRGLSL+AARYALLR+E GPPHTKNWRPQ+LV+L LD + VK+PRLL+F SQL
Sbjct: 659 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQL 718
Query: 719 KAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLI 778
KAGKGLTIVGSV++G++L+ + EAQ AE+ I+++M EK KGFCQ+VV+S +R+G++HLI
Sbjct: 719 KAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLI 778
Query: 779 QSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQ 838
QS GLGG++HN+V++ WP W+Q ++P +WK F+DTVR TTAAH ALLV KN+ +P N
Sbjct: 779 QSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH 838
Query: 839 ERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMF 898
ER+ GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ+DDNSIQMKKDL +F
Sbjct: 839 ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVF 898
Query: 899 LYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNT 958
LYHLR+ AEVEVVEM +DISA+TYERTLMMEQRSQML+QM+L+K E+EREAQL+ DR++
Sbjct: 899 LYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHS 958
Query: 959 ASHTAAA---ARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVR 1015
A + ++ DK+QMTWTR+K + E + + F++L +KPDQSNVR
Sbjct: 959 ALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETW-DPSHAPDNFRELVHIKPDQSNVR 1017
Query: 1016 RMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGG 1075
RMHTAVKLN V++ +S DA+LVLLNMPGPP+N +GDENYMEFLEVLTEGL RVLLVRGGG
Sbjct: 1018 RMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGG 1077
Query: 1076 REVITIYS 1083
REVITIYS
Sbjct: 1078 REVITIYS 1085
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 1503 bits (3892), Expect = 0.0
Identities = 750/1062 (70%), Positives = 869/1062 (81%), Gaps = 12/1062 (1%)
Query: 31 PEGPEPERPSP-GDGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKL 89
PE EP G GN RE+SPFL+ +E + + +N+ALFEEE+D P VSSLL KL
Sbjct: 21 PEDTEPLASCTLGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKL 80
Query: 90 ANYTNLSQGVVEHEEDEE---SRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVG 146
+YTNL+QG EHEE E +RRR A+AP MGT +GVYLPCLQNI GVILFLRLTW+VG
Sbjct: 81 VSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVG 140
Query: 147 VAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFY 206
AGVL++ LIV +CC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFY
Sbjct: 141 TAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFY 200
Query: 207 LGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVV 266
LGTTFA AMYILG IEI LTYI+P AAIF A + A L+NMRVYGT L M LVV
Sbjct: 201 LGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVV 260
Query: 267 FVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKA 326
FVGVKYVNK A +FLACV++SIL+IYAG IKS FDPP PVC+LGNRTLSR FD C K
Sbjct: 261 FVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKT 320
Query: 327 YGIHNNSATSALWGLFCNGSQPSA-ACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAH 385
+ N + + LW FC+ + +CD YF+ NNVTEI GIPGAA+GV ENLWS Y
Sbjct: 321 AVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLE 380
Query: 386 AGAFVEKKGVPSVPVAEESRASALP-YVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDL 444
G VEK G+PS S +LP YV+ DIA SFT+LVGI+FPSVTGIMAGSNRSGDL
Sbjct: 381 KGDIVEKHGLPSADAP--SLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDL 438
Query: 445 KDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSP 504
+DAQKSIP GTILAI+TTS +Y S +VLFGACIEGVVLRDK+G+ + NLV+G LAWPSP
Sbjct: 439 RDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSP 498
Query: 505 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLI 564
WVIVIGSFFSTCGAGLQSLTGAPRLLQAIA+D I+PFL+VFGHGK NGEPTWALLLT LI
Sbjct: 499 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALI 558
Query: 565 CETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMS 624
E GILIASLD VAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFK+YHW LSFLGMS
Sbjct: 559 AELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS 618
Query: 625 LCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGP 684
LCLALMF+ SWYYAL AMLIAG IYKYIEY+GAEKEWGDGIRGLSL+AARYALLR+E GP
Sbjct: 619 LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 678
Query: 685 PHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQR 744
PHTKNWRPQ+LV+L LD + VK+PRLL+F SQLKAGKGLTIVGSV++G++L+ + EAQ
Sbjct: 679 PHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 738
Query: 745 AEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDN 804
AE+ I+++M EK KGFCQ+VV+S +R+G++HLIQS GLGG++HN+V++ WP W+Q ++
Sbjct: 739 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSED 798
Query: 805 PFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFL 864
P +WK F+DTVR TTAAH ALLV KN+ +P N ER+ GHIDVWWIVHDGGMLMLLPFL
Sbjct: 799 PRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFL 858
Query: 865 LRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYE 924
LRQHKVWRKCRMRIFTVAQ+DDNSIQMKKDL +FLYHLR+ AEVEVVEM +DISA+TYE
Sbjct: 859 LRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYE 918
Query: 925 RTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAA---ARTQAPPTPDKVQMTW 981
RTLMMEQRSQML+QM+L+K E+EREAQL+ DR++A + ++ DK+QMTW
Sbjct: 919 RTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW 978
Query: 982 TREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNM 1041
TR+K + E + + F++L +KPDQSNVRRMHTAVKLN V++ +S DA+LVLLNM
Sbjct: 979 TRDKYMTETW-DPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNM 1037
Query: 1042 PGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1083
PGPP+N +GDENYMEFLEVLTEGL RVLLVRGGGREVITIYS
Sbjct: 1038 PGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 1489 bits (3856), Expect = 0.0
Identities = 752/1088 (69%), Positives = 874/1088 (80%), Gaps = 19/1088 (1%)
Query: 4 NFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQESF 63
+FTVVPV+ G D E E E + S G GN RE+SPFL+ +E +
Sbjct: 3 HFTVVPVDGPRRGDYDNL-EGLSWVDYGERAELD-DSDGHGNHRESSPFLSPLEASRGID 60
Query: 64 FEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEE---SRRREAKAPRMGT 120
+ +N+ALFEEE+D P VSSLL KL +YTNL+QG EHEE E +RRR A+AP MGT
Sbjct: 61 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 120
Query: 121 FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVV 180
+GVYLPCLQNI GVILFLRLTW+VG AGVL++ LIV +CC CT+LTAISMSAIATNGVV
Sbjct: 121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 180
Query: 181 PAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAA 240
PAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYILG IEI LTYI+P AAIF A
Sbjct: 181 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 240
Query: 241 GGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAF 300
+ A L+NMRVYGT L M LVVFVGVKYVNK A +FLACV++SIL+IYAG IKS F
Sbjct: 241 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 300
Query: 301 DPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSA-ACDEYFIQN 359
DPP PVC+LGNRTLSR FD C K + N + + LW FC+ + +CD YF+ N
Sbjct: 301 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 360
Query: 360 NVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALP-YVLTDIAA 418
NVTEI GIPGAA+GV ENLWS Y G VEK G+PS S +LP YV+ DIA
Sbjct: 361 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAP--SLKESLPLYVVADIAT 418
Query: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
SFT+LVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTILAI+TTS +Y S +VLFGACIE
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 479 GVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGI 538
GVVLRDK+G+ + NLV+G LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA+D I
Sbjct: 479 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 538
Query: 539 VPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAV 598
+PFL+VFGHGK NGEPTWALLLT LI E GILIASLD VAPILSMFFLMCYLFVNLACAV
Sbjct: 539 IPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAV 598
Query: 599 QTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAE 658
QTLLRTPNWRPRFK+YHW LSFLGMSLCLALMF+ SWYYAL AMLIAG IYKYIEY+GAE
Sbjct: 599 QTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 658
Query: 659 KEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQL 718
KEWGDGIRGLSL+AARYALLR+E GPPHTKNWRPQ+LV+L LD + VK+PRLL+F SQL
Sbjct: 659 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQL 718
Query: 719 KAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLI 778
KAGKGLTIVGSV++G++L+ + EAQ AE+ I+++M EK KGFCQ+VV+S +R+G++HLI
Sbjct: 719 KAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLI 778
Query: 779 QSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQ 838
QS GLGG++HN+V++ WP W+Q ++P +WK F+DTVR TTAAH ALLV KN+ +P N
Sbjct: 779 QSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH 838
Query: 839 ERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMF 898
ER+ GHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ+DDNSIQMKKDL +F
Sbjct: 839 ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVF 898
Query: 899 LYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNT 958
LYHLR+ AE +DISA+TYERTLMMEQRSQML+QM+L+K E+EREAQL+ DR++
Sbjct: 899 LYHLRLEAE------HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHS 952
Query: 959 ASHTAAA---ARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVR 1015
A + ++ DK+QMTWTR+K + E + + F++L +KPDQSNVR
Sbjct: 953 ALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETW-DPSHAPDNFRELVHIKPDQSNVR 1011
Query: 1016 RMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGG 1075
RMHTAVKLN V++ +S DA+LVLLNMPGPP+N +GDENYMEFLEVLTEGL RVLLVRGGG
Sbjct: 1012 RMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGG 1071
Query: 1076 REVITIYS 1083
REVITIYS
Sbjct: 1072 REVITIYS 1079
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 1473 bits (3814), Expect = 0.0
Identities = 731/1018 (71%), Positives = 843/1018 (82%), Gaps = 11/1018 (1%)
Query: 74 EEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEE---SRRREAKAPRMGTFIGVYLPCLQ 130
EE+D P VSSLL KL +YTNL+QG EHEE E +RRR A+AP MGT +GVYLPCLQ
Sbjct: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
Query: 131 NILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMIS 190
NI GVILFLRLTW+VG AGVL++ LIV +CC CT+LTAISMSAIATNGVVPAGGSY+MIS
Sbjct: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
Query: 191 RSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHN 250
RSLGPEFGGAVGLCFYLGTTFA AMYILG IEI LTYI+P AAIF A + A L+N
Sbjct: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
Query: 251 MRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLL 310
MRVYGT L M LVVFVGVKYVNK A +FLACV++SIL+IYAG IKS FDPP PVC+L
Sbjct: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
Query: 311 GNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSA-ACDEYFIQNNVTEIQGIPG 369
GNRTLSR FD C K + N + + LW FC+ + +CD YF+ NNVTEI GIPG
Sbjct: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
Query: 370 AASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALP-YVLTDIAASFTLLVGIYF 428
AA+GV ENLWS Y G VEK G+PS S +LP YV+ DIA SFT+LVGI+F
Sbjct: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAP--SLKESLPLYVVADIATSFTVLVGIFF 430
Query: 429 PSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE 488
PSVTGIMAGSNRSGDL+DAQKSIP GTILAI+TTS +Y S +VLFGACIEGVVLRDK+G+
Sbjct: 431 PSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGD 490
Query: 489 ALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHG 548
+ NLV+G LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA+D I+PFL+VFGHG
Sbjct: 491 GVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHG 550
Query: 549 KANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWR 608
K NGEPTWALLLT LI E GILIASLD VAPILSMFFLMCYLFVNLACAVQTLLRTPNWR
Sbjct: 551 KVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWR 610
Query: 609 PRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGL 668
PRFK+YHW LSFLGMSLCLALMF+ SWYYAL AMLIAG IYKYIEY+GAEKEWGDGIRGL
Sbjct: 611 PRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGL 670
Query: 669 SLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVG 728
SL+AARYALLR+E GPPHTKNWRPQ+LV+L LD + VK+PRLL+F SQLKAGKGLTIVG
Sbjct: 671 SLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVG 730
Query: 729 SVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKH 788
SV++G++L+ + EAQ AE+ I+++M EK KGFCQ+VV+S +R+G++HLIQS GLGG++H
Sbjct: 731 SVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRH 790
Query: 789 NTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDV 848
N+V++ WP W+Q ++P +WK F+DTVR TTAAH ALLV KN+ +P N ER+ GHIDV
Sbjct: 791 NSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDV 850
Query: 849 WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEV 908
WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ+DDNSIQMKKDL +FLYHLR+ AEV
Sbjct: 851 WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEV 910
Query: 909 EVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAA--- 965
EVVEM +DISA+TYERTLMMEQRSQML+QM+L+K E+EREAQL+ DR++A +
Sbjct: 911 EVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSD 970
Query: 966 ARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNG 1025
++ DK+QMTWTR+K + E + + F++L +KPDQSNVRRMHTAVKLN
Sbjct: 971 EEDESAVGADKIQMTWTRDKYMTETW-DPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNE 1029
Query: 1026 VVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1083
V++ +S DA+LVLLNMPGPP+N +GDENYMEFLEVLTEGL RVLLVRGGGREVITIYS
Sbjct: 1030 VIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 238 bits (606), Expect = 3e-62
Identities = 192/737 (26%), Positives = 319/737 (43%), Gaps = 129/737 (17%)
Query: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACI- 477
+F + I+FPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C+
Sbjct: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
Query: 478 --EGVVLRD------------------KFGEALQGNL----------VIGMLAWPSPWVI 507
VL D F E Q + + M++ +P +I
Sbjct: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAP-LI 457
Query: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKA-NGEPTWALLLTVLICE 566
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
Query: 567 TGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLC 626
I+IA L+++API+S FFL Y +N +C ++ +P WRP F++Y+ + G +
Sbjct: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
Query: 627 LALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPH 686
+ +MF+ +W+ AL A+ + + Y+ Y+ E WG ++ S N A + + H
Sbjct: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
Query: 687 TKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAE 746
KN+RPQ LV+ P L+ F L I G VL G + + E Q
Sbjct: 638 IKNYRPQCLVLTG----PPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
Query: 747 ENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPF 806
++ K K F V++ LR G+ L+Q+AGLG +K N +++ + +W Q +P
Sbjct: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
Query: 807 SWKNFVDTVRDTTAAHQALLVAK-----NVDSFPQN------------------------ 837
+ ++++ + D + + V + NV Q
Sbjct: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVDPKAL 812
Query: 838 ----------QERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDN 887
Q G ID++W+ DGG+ +L+P+LL + + W KC++R+F Q+ +
Sbjct: 813 VKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQI-NR 871
Query: 888 SIQMKKDLQMFLYHLRIS-AEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQ 946
Q +K + L R+ EV ++ + + A E T E M+ +L+ +
Sbjct: 872 MDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE---DMIAPFRLNDGFK 925
Query: 947 EREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFS 1006
+ T R P ++T R K + +
Sbjct: 926 DEA------------TVNEMRRDCPWKISDEEITKNRVKSLRQ----------------- 956
Query: 1007 MKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLN 1066
V+LN +VL+ S+DA L+++ +P K + YM +LE L++ L
Sbjct: 957 --------------VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1002
Query: 1067 -RVLLVRGGGREVITIY 1082
V+L+RG V+T Y
Sbjct: 1003 PPVILIRGNQENVLTFY 1019
Score = 125 bits (313), Expect = 3e-28
Identities = 74/253 (29%), Positives = 128/253 (50%), Gaps = 24/253 (9%)
Query: 44 GNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHE 103
G PR+ P L ++ SF + + L DS P ++ G+VE E
Sbjct: 77 GEPRKVRPTLADLH----SFLKQEGRHLHALAFDSRPS-----------HEMTDGLVEGE 121
Query: 104 EDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTC 163
S + + R G GV + C+ NI GVIL+LRL WI AG++ +++I+ + T
Sbjct: 122 AGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTV 181
Query: 164 TMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEI 223
T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G E
Sbjct: 182 TSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAET 241
Query: 224 FLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLAC 283
+ + G ++++R+ G ++ ++ + G+++ +K ++F
Sbjct: 242 VRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLV 292
Query: 284 VVLSILAIYAGVI 296
+++S G +
Sbjct: 293 IMVSFANYLVGTL 305
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 234 bits (597), Expect = 3e-61
Identities = 192/746 (25%), Positives = 319/746 (42%), Gaps = 138/746 (18%)
Query: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACI- 477
+F + I+FPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C+
Sbjct: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
Query: 478 --EGVVLRD------------------KFGEALQGNL----------VIGMLAWPSPWVI 507
VL D F E Q + + M++ +P +I
Sbjct: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAP-LI 456
Query: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKA-NGEPTWALLLTVLICE 566
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 516
Query: 567 TGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLC 626
I+IA L+++API+S FFL Y +N +C ++ +P WRP F++Y+ + G +
Sbjct: 517 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 576
Query: 627 LALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPH 686
+ +MF+ +W+ AL A+ + + Y+ Y+ E WG ++ S N A + + H
Sbjct: 577 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 636
Query: 687 TKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAE 746
KN+RPQ LV+ P L+ F L I G VL G + + E Q
Sbjct: 637 IKNYRPQCLVLTG----PPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 692
Query: 747 ENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPF 806
++ K K F V++ LR G+ L+Q+AGLG +K N +++ + +W Q +P
Sbjct: 693 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 751
Query: 807 SWKNFVDTVRDTTAAHQALLVAK-----NVDSFPQN------------------------ 837
+ ++++ + D + + V + NV Q
Sbjct: 752 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 811
Query: 838 -------------------QERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
Q G ID++W+ DGG+ +L+P+LL + + W KC++R+
Sbjct: 812 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 871
Query: 879 FTVAQVDDNSIQMKKDLQMFLYHLRIS-AEVEVVEMVENDISAFTYERTLMMEQRSQMLK 937
F Q+ + Q +K + L R+ EV ++ + + A E T E M+
Sbjct: 872 FVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE---DMIA 924
Query: 938 QMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTS 997
+L+ ++ T R P ++T R K + +
Sbjct: 925 PFRLNDGFKDEA------------TVNEMRRDCPWKISDEEITKNRVKSLRQ-------- 964
Query: 998 LSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEF 1057
V+LN +VL+ S+DA L+++ +P K + YM +
Sbjct: 965 -----------------------VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAW 1001
Query: 1058 LEVLTEGLN-RVLLVRGGGREVITIY 1082
LE L++ L V+L+RG V+T Y
Sbjct: 1002 LETLSQDLRPPVILIRGNQENVLTFY 1027
Score = 122 bits (307), Expect = 1e-27
Identities = 63/202 (31%), Positives = 112/202 (55%), Gaps = 9/202 (4%)
Query: 95 LSQGVVEHEEDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESF 154
++ G+VE E S + + R G GV + C+ NI GVIL+LRL WI AG++ ++
Sbjct: 112 MTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTW 171
Query: 155 LIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGA 214
+I+ + T T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F A
Sbjct: 172 IIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVA 231
Query: 215 MYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVN 274
M+ +G E + + G ++++R+ G ++ ++ + G+++ +
Sbjct: 232 MHTVGFAETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWES 282
Query: 275 KLALVFLACVVLSILAIYAGVI 296
K ++F +++S G +
Sbjct: 283 KAQVLFFLVIMVSFANYLVGTL 304
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 234 bits (597), Expect = 3e-61
Identities = 192/746 (25%), Positives = 319/746 (42%), Gaps = 138/746 (18%)
Query: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACI- 477
+F + I+FPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C+
Sbjct: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
Query: 478 --EGVVLRD------------------KFGEALQGNL----------VIGMLAWPSPWVI 507
VL D F E Q + + M++ +P +I
Sbjct: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAP-LI 457
Query: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKA-NGEPTWALLLTVLICE 566
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
Query: 567 TGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLC 626
I+IA L+++API+S FFL Y +N +C ++ +P WRP F++Y+ + G +
Sbjct: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
Query: 627 LALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPH 686
+ +MF+ +W+ AL A+ + + Y+ Y+ E WG ++ S N A + + H
Sbjct: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
Query: 687 TKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAE 746
KN+RPQ LV+ P L+ F L I G VL G + + E Q
Sbjct: 638 IKNYRPQCLVLTG----PPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
Query: 747 ENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPF 806
++ K K F V++ LR G+ L+Q+AGLG +K N +++ + +W Q +P
Sbjct: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
Query: 807 SWKNFVDTVRDTTAAHQALLVAK-----NVDSFPQN------------------------ 837
+ ++++ + D + + V + NV Q
Sbjct: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 812
Query: 838 -------------------QERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
Q G ID++W+ DGG+ +L+P+LL + + W KC++R+
Sbjct: 813 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 872
Query: 879 FTVAQVDDNSIQMKKDLQMFLYHLRIS-AEVEVVEMVENDISAFTYERTLMMEQRSQMLK 937
F Q+ + Q +K + L R+ EV ++ + + A E T E M+
Sbjct: 873 FVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE---DMIA 925
Query: 938 QMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTS 997
+L+ ++ T R P ++T R K + +
Sbjct: 926 PFRLNDGFKDEA------------TVNEMRRDCPWKISDEEITKNRVKSLRQ-------- 965
Query: 998 LSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEF 1057
V+LN +VL+ S+DA L+++ +P K + YM +
Sbjct: 966 -----------------------VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAW 1002
Query: 1058 LEVLTEGLN-RVLLVRGGGREVITIY 1082
LE L++ L V+L+RG V+T Y
Sbjct: 1003 LETLSQDLRPPVILIRGNQENVLTFY 1028
Score = 125 bits (313), Expect = 3e-28
Identities = 74/253 (29%), Positives = 128/253 (50%), Gaps = 24/253 (9%)
Query: 44 GNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHE 103
G PR+ P L ++ SF + + L DS P ++ G+VE E
Sbjct: 77 GEPRKVRPTLADLH----SFLKQEGRHLHALAFDSRPS-----------HEMTDGLVEGE 121
Query: 104 EDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTC 163
S + + R G GV + C+ NI GVIL+LRL WI AG++ +++I+ + T
Sbjct: 122 AGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTV 181
Query: 164 TMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEI 223
T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G E
Sbjct: 182 TSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAET 241
Query: 224 FLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLAC 283
+ + G ++++R+ G ++ ++ + G+++ +K ++F
Sbjct: 242 VRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLV 292
Query: 284 VVLSILAIYAGVI 296
+++S G +
Sbjct: 293 IMVSFANYLVGTL 305
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 221 bits (562), Expect = 4e-57
Identities = 144/422 (34%), Positives = 214/422 (50%), Gaps = 48/422 (11%)
Query: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
+F + I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+ +Y+ V G+C
Sbjct: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
Query: 479 GVVLRDKFGEA---------------------------------LQGNL-VIGMLAWPSP 504
V+RD G L N V+ M++ +P
Sbjct: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
Query: 505 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVF--GHGKANGEPTWALLLTV 562
+I G F +T + L SL AP++ QA+ +D I P Q+F G+GK N EP +LT
Sbjct: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
Query: 563 LICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLG 622
LI ILIA L+ +API+S FFL Y +N + +L ++P WRP FK+Y+ +S LG
Sbjct: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
Query: 623 MSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLS-LNAARYALLRVE 681
LC +MF+ +W+ AL +I +Y Y+ Y+ + WG + L+ LNA +++ +R+
Sbjct: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHS-IRLS 778
Query: 682 HGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHME 741
H KN+RPQ LVM + P LL GL I G V G E
Sbjct: 779 GVEDHVKNFRPQCLVMTGAPNSR----PALLHLVHDFTKNVGLMICGHVHMGPRRQAMKE 834
Query: 742 AQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQ 801
+ + + K K F V + LR+G +L+Q+AGLG +K NT+++ + W Q
Sbjct: 835 MSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQ 894
Query: 802 ED 803
D
Sbjct: 895 AD 896
Score = 131 bits (330), Expect = 3e-30
Identities = 82/232 (35%), Positives = 126/232 (54%), Gaps = 34/232 (14%)
Query: 57 EVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAP 116
E+E+E F +G F +S P +++ YT S+GVV
Sbjct: 249 ELEKEPFEDG-----FANGEESTPTRDAVVT----YTAESKGVV---------------- 283
Query: 117 RMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIAT 176
+ G GV + C+ NI GV+LF+RL+WIVG AG+ S L++ M T +T +S SAIAT
Sbjct: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
Query: 177 NGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQ 236
NG V GG+YY+ISRSLGPEFGGA+GL F A AMY++G E + + + +
Sbjct: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMI 403
Query: 237 AEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSI 288
E ++++R+ G T+V++ + G+++ K +V L ++L+I
Sbjct: 404 DE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
Score = 74.3 bits (181), Expect = 6e-13
Identities = 60/257 (23%), Positives = 120/257 (46%), Gaps = 53/257 (20%)
Query: 829 KNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNS 888
K +++ Q Q++ G IDVWW+ DGG+ +L+P+LL K W+ C++R+F ++ N
Sbjct: 1007 KLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NR 1064
Query: 889 IQM-KKDLQMFLYHLRIS-AEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQ 946
I ++ + L RI +++ MV DI+ + ++ + ++++ +L ++++
Sbjct: 1065 IDHDRRAMATLLSKFRIDFSDI----MVLGDINTKPKKENIIAFE--EIIEPYRLHEDDK 1118
Query: 947 EREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFS 1006
E++ DK++ E +R D L +K
Sbjct: 1119 EQD-----------------------IADKMKED--------EPWRITDNELELYK---- 1143
Query: 1007 MKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLN 1066
+ + ++LN ++ S A ++++++P K YM +LE L++ L
Sbjct: 1144 --------TKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLP 1195
Query: 1067 RVLLVRGGGREVITIYS 1083
+LLVRG + V+T YS
Sbjct: 1196 PILLVRGNHQSVLTFYS 1212
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 208 bits (529), Expect = 3e-53
Identities = 142/457 (31%), Positives = 221/457 (48%), Gaps = 51/457 (11%)
Query: 420 FTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEG 479
F + I+FP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
Query: 480 VVLRDKFGE---------------------------------ALQGNL-VIGMLAWPSPW 505
V+RD G L N V+ M++ P
Sbjct: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGP- 494
Query: 506 VIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVF--GHGKANGEPTWALLLTVL 563
+I G F +T + L SL AP++ QA+ +D I LQ F G+GK N EP +LT L
Sbjct: 495 LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFL 553
Query: 564 ICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGM 623
I ILIA L+++API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 554 IAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGA 613
Query: 624 SLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHG 683
LC A+MF+ +W+ A+ +I +Y Y+ + + WG + LS +A L +
Sbjct: 614 VLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTV 673
Query: 684 PPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEG--TYLDKHME 741
H KN+RPQ +V+ + P LL T GL I V G K M
Sbjct: 674 EDHVKNFRPQCIVLTG----GPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMN 729
Query: 742 AQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQ 801
+ A++ ++ + K K F V + RDG+ L+Q++GLG +K NT+++ + +W++
Sbjct: 730 SGMAKK--QAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
Query: 802 EDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQ 838
+N+V + D +++ + F +Q
Sbjct: 788 APLT-EIENYVGIIHDAFDFEIGVVIVRISQGFDISQ 823
Score = 129 bits (324), Expect = 1e-29
Identities = 78/249 (31%), Positives = 133/249 (53%), Gaps = 20/249 (8%)
Query: 49 NSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVS-SLLNKLANYTNLSQGVVEHEEDEE 107
N+ ++ +V + S E E++ N V+ S +++AN G+ E+ E
Sbjct: 117 NTGSISGPKVNRPSLLE------IHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAEN 166
Query: 108 SRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLT 167
+A + G GV + C+ NI GV+LF+RL+WIVG AG+ LI+ + T +T
Sbjct: 167 KEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
Query: 168 AISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTY 227
+S SAIATNG V GG+YY+ISRSLGPEFGG++GL F A AMY++G E +
Sbjct: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDL 286
Query: 228 ISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLS 287
+ ++ +++R+ G+ T+V++ + G+++ K ++ L ++++
Sbjct: 287 LKESDSMM---------VDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIA 337
Query: 288 ILAIYAGVI 296
I + G +
Sbjct: 338 IANFFIGTV 346
Score = 80.5 bits (197), Expect = 8e-15
Identities = 65/273 (23%), Positives = 119/273 (43%), Gaps = 55/273 (20%)
Query: 814 TVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRK 873
++ + + H K V++ Q +++ G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 879 SINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKD 938
Query: 874 CRMRIFT---VAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMME 930
C++RI+ + ++++ I M L F A++ ++ DI+ +
Sbjct: 939 CKLRIYVGGKINRIEEEKIVMASLLSKFRIKF---ADIHII----GDIN---------IR 982
Query: 931 QRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEK 990
+ K E+ E +H+ TA + + P
Sbjct: 983 PNKESWKVF-----EEMIEPYRLHESCKDLTTAEKLKRETP------------------- 1018
Query: 991 YRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQG 1050
++ D L K+ + + V+LN ++ S+ A L++L++P K
Sbjct: 1019 WKITDAELEAVKE------------KSYRQVRLNELLQEHSRAANLIVLSLPVARKGSIS 1066
Query: 1051 DENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1083
D YM +LE+LT+ L VLLVRG + V+T YS
Sbjct: 1067 DLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 197 bits (501), Expect = 4e-50
Identities = 151/558 (27%), Positives = 256/558 (45%), Gaps = 77/558 (13%)
Query: 414 TDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLF 473
T +F + + F TGIMAG+N SG+LKD ++IP GTI+A+ T F+Y+ L
Sbjct: 261 TGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLS 320
Query: 474 GACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI 533
+ +L++ +G + WP +++IG + + A + SL GA R+L A+
Sbjct: 321 SFTCDRTLLQEDYG------FFRAISLWPP--LVLIGIYATALSASMSSLIGASRILHAL 372
Query: 534 ARDGIVPFLQVFGHGKANGEPTWALLLTVL-ICETGILIASLDSVAPILSMFFLMCYLFV 592
ARD + + + G WA +L + + +L L+++A ++++F+L+ Y V
Sbjct: 373 ARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAV 432
Query: 593 NLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYI 652
+L+C PN+RP F + W LG++ CL +MF+ S A ++L+ G + +
Sbjct: 433 DLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALL 492
Query: 653 EYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPR-- 710
RG WG + L + R LLR++ H K WRPQ+L++ V +PR
Sbjct: 493 TARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL--------VGNPRGA 544
Query: 711 --LLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENI-RSLMSTEKTKGFCQLVVS 767
LL +QLK G GL ++G V G + + + SL+ + K F L +S
Sbjct: 545 LPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLS 603
Query: 768 SSLRDGMSHLIQSAGLGGLKHNTVLMAW------------------PASWKQEDN----- 804
S+R G HL++ +GLGG+K NT+++ + PA +E +
Sbjct: 604 PSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSPALS 663
Query: 805 -------------PFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGG------H 845
+ +++V TV D ++ +++A+ + P + G G H
Sbjct: 664 TLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQLHH 723
Query: 846 IDVW------------WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKK 893
+DVW ++ G L+ + +L W R+RIF + +
Sbjct: 724 VDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGAAEG 783
Query: 894 DLQMFLYHLRISAEVEVV 911
L+ L LRI AEV+ V
Sbjct: 784 RLRALLSQLRIRAEVQEV 801
Score = 108 bits (269), Expect = 4e-23
Identities = 67/190 (35%), Positives = 107/190 (56%), Gaps = 18/190 (9%)
Query: 113 AKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMS 172
A A ++ TF+GV +P + ++ +++FLR+ ++VG AG+L++ ++ + LT +S+
Sbjct: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
Query: 173 AIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGA 232
AIATNG V GG+Y+MISR+LGPE GG++GL FYL A+ +LG +E L
Sbjct: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLD------ 145
Query: 233 AIFQAEAAGGEAAAMLHN----MRVYGTCTLVLMALVVFVGV-KYVNKLALVF------L 281
+F A+A G +L +YG+ L L+ V +G Y L F L
Sbjct: 146 -VFGADATGPSGLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSL 204
Query: 282 ACVVLSILAI 291
A V++S +A+
Sbjct: 205 ASVLISFVAV 214
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 102 bits (253), Expect = 3e-21
Identities = 57/176 (32%), Positives = 101/176 (57%), Gaps = 9/176 (5%)
Query: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
SF + G++FP+ TG+MAG N GDL++ SIP G++ A+ + F+Y+ + L GA
Sbjct: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
Query: 479 GVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGI 538
LR F A + +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
Query: 539 VPFLQVFGHGKA-NGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVN 593
+P L G GK N P A+ LT L+ + + ++ +API+++ F++ Y+ V+
Sbjct: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
Score = 93.2 bits (230), Expect = 1e-18
Identities = 71/242 (29%), Positives = 107/242 (44%), Gaps = 27/242 (11%)
Query: 119 GTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNG 178
GT+ GV+ C+ NI GV+LFLR W+VG GVL +V+ ++T +S +
Sbjct: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
Query: 179 VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAE 238
+ +GG Y MIS LG + GG +GL + G AGAMYI G E + G
Sbjct: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLG------- 152
Query: 239 AAGGEAAAMLHNMRVYGTCTLVLMAL--VVFVGVKYVNKLALVFLACVVLSILAIYAGVI 296
+ V G VL+AL + GVK++ +L L+ L + +S L G
Sbjct: 153 ----------NIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF 202
Query: 297 KSAFDPPD-----IPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGS--QPS 349
+ DP P L N ++ +G+ +AT + G G +P+
Sbjct: 203 -THLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPA 261
Query: 350 AA 351
A+
Sbjct: 262 AS 263
Score = 32.3 bits (72), Expect = 2.5
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 6/51 (11%)
Query: 607 WRPRFKFYH-----WTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYI 652
WR FY W +S LG L +MF+ W Y L M +A +Y YI
Sbjct: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
>gi|33286430 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform b [Homo
sapiens]
Length = 332
Score = 45.4 bits (106), Expect = 3e-04
Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 9/162 (5%)
Query: 443 DLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQ-GNLVIGMLAW 501
+L D K++P ++I +F+Y+ V + + L A+ G ++G++AW
Sbjct: 54 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 113
Query: 502 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLT 561
P I ST G SL + RL A AR+G +P + H K P ALL T
Sbjct: 114 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 168
Query: 562 VLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLR 603
C + +L+ + +++ + YLF + A Q +LR
Sbjct: 169 ---CISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLR 207
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 45.4 bits (106), Expect = 3e-04
Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 9/162 (5%)
Query: 443 DLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQ-GNLVIGMLAW 501
+L D K++P ++I +F+Y+ V + + L A+ G ++G++AW
Sbjct: 257 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 316
Query: 502 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLT 561
P I ST G SL + RL A AR+G +P + H K P ALL T
Sbjct: 317 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 371
Query: 562 VLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLR 603
C + +L+ + +++ + YLF + A Q +LR
Sbjct: 372 ---CISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLR 410
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 40.0 bits (92), Expect = 0.012
Identities = 45/195 (23%), Positives = 79/195 (40%), Gaps = 20/195 (10%)
Query: 409 LPY----VLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSF 464
+PY L A F VG + TG ++++ QK+IP G + +++
Sbjct: 290 MPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFM 341
Query: 465 IYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAW-PSPWVIVIGSFFSTCGAGLQSL 523
Y + +L +K + V W P+ +V+ GS + + L S+
Sbjct: 342 AYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSM 397
Query: 524 TGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSM 583
PR+L A+ARDG++ + P A L +I + L ++ ++S+
Sbjct: 398 FPLPRILFAMARDGLL--FRFLARVSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSI 455
Query: 584 FFLMCYLFVNLACAV 598
LM Y V AC +
Sbjct: 456 GTLMAYSLV-AACVL 469
>gi|110347453 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 4 [Homo sapiens]
Length = 635
Score = 36.6 bits (83), Expect = 0.13
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 3/89 (3%)
Query: 505 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGE-PTWALLLTVL 563
+++ GS + L L PR++ A+A DG+ F QVF H + P L L
Sbjct: 319 FIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGL--FFQVFAHVHPRTQVPVAGTLAFGL 376
Query: 564 ICETGILIASLDSVAPILSMFFLMCYLFV 592
+ L+ L+S+ LS+ L+ Y FV
Sbjct: 377 LTAFLALLLDLESLVQFLSLGTLLAYTFV 405
>gi|113722133 senataxin [Homo sapiens]
Length = 2677
Score = 35.8 bits (81), Expect = 0.23
Identities = 29/102 (28%), Positives = 40/102 (39%), Gaps = 11/102 (10%)
Query: 1 MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGD-------GNPRENSPFL 53
+PTN +V GGGD TA E EG EP+ S + N E+
Sbjct: 1451 VPTNEVIVSTSEDPLGGGDPTARHIEMAALKEG-EPDSSSDAEEDNLFLTQNDPEDMDLC 1509
Query: 54 NNVEVEQESFFE---GKNMALFEEEMDSNPMVSSLLNKLANY 92
+ +E + E GK+ EE+ S P + SL Y
Sbjct: 1510 SQMENDNYKLIELIHGKDTVEVEEDSVSRPQLESLSGTKCKY 1551
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 35.8 bits (81), Expect = 0.23
Identities = 43/195 (22%), Positives = 79/195 (40%), Gaps = 19/195 (9%)
Query: 409 LPY----VLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSF 464
+PY L A F VG + TG ++++ QK+IP G + +++
Sbjct: 250 MPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFM 301
Query: 465 IYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAW-PSPWVIVIGSFFSTCGAGLQSL 523
Y + +L +K + V W P+ +V+ GS + + L S+
Sbjct: 302 AYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSI 357
Query: 524 TGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSM 583
PR++ A+A DG++ F + P A L + + + L ++ ++S+
Sbjct: 358 FPMPRVIYAMAEDGLL-FKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSI 416
Query: 584 FFLMCYLFVNLACAV 598
LM Y V AC +
Sbjct: 417 GTLMAYSLV-AACVL 430
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 35.4 bits (80), Expect = 0.29
Identities = 39/187 (20%), Positives = 79/187 (42%), Gaps = 12/187 (6%)
Query: 412 VLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIV 471
+L A F VG + TG A ++ Q+SIP G ++++ Y +
Sbjct: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
Query: 472 LFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 531
+ L+ + + L IG P+ +V+ +GS + + L S+ PR++
Sbjct: 305 ALTLMMPYYQLQPE-SPLPEAFLYIGWA--PARYVVAVGSLCALSTSLLGSMFPMPRVIY 361
Query: 532 AIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLF 591
A+A DG++ F + P A +++ +I + L + ++S+ L+ Y
Sbjct: 362 AMAEDGLL-FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420
Query: 592 VNLACAV 598
V++ +
Sbjct: 421 VSICVLI 427
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 35.4 bits (80), Expect = 0.29
Identities = 39/187 (20%), Positives = 79/187 (42%), Gaps = 12/187 (6%)
Query: 412 VLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIV 471
+L A F VG + TG A ++ Q+SIP G ++++ Y +
Sbjct: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
Query: 472 LFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 531
+ L+ + + L IG P+ +V+ +GS + + L S+ PR++
Sbjct: 305 ALTLMMPYYQLQPE-SPLPEAFLYIGWA--PARYVVAVGSLCALSTSLLGSMFPMPRVIY 361
Query: 532 AIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLF 591
A+A DG++ F + P A +++ +I + L + ++S+ L+ Y
Sbjct: 362 AMAEDGLL-FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420
Query: 592 VNLACAV 598
V++ +
Sbjct: 421 VSICVLI 427
>gi|181337167 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 14 [Homo sapiens]
Length = 771
Score = 35.4 bits (80), Expect = 0.29
Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 14/184 (7%)
Query: 412 VLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIV 471
VL A F +G + TG A K+ SIP ++V Y+S V
Sbjct: 254 VLQGAATCFYAFIGFDIIATTGEEA--------KNPNTSIPYAITASLVICLTAYVSVSV 305
Query: 472 LFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 531
+ + + D ++ + G A + +V+ IGS + L SL PR++
Sbjct: 306 ILTLMVPYYTI-DTESPLMEMFVAHGFYA--AKFVVAIGSVAGLTVSLLGSLFPMPRVIY 362
Query: 532 AIARDGIVPFLQVFGHGKANGE-PTWALLLTVLICETGILIASLDSVAPILSMFFLMCYL 590
A+A DG++ + H + E P A +++ + L+ SL + ++S+ L+ Y
Sbjct: 363 AMAGDGLL--FRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYT 420
Query: 591 FVNL 594
V++
Sbjct: 421 LVSV 424
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,498,216
Number of Sequences: 37866
Number of extensions: 1819445
Number of successful extensions: 7161
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 6999
Number of HSP's gapped (non-prelim): 122
length of query: 1083
length of database: 18,247,518
effective HSP length: 113
effective length of query: 970
effective length of database: 13,968,660
effective search space: 13549600200
effective search space used: 13549600200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.