Search of human proteins with 32483397

Search of human proteins with 32483397

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32483397 dopamine receptor D4 [Homo sapiens]
         (419 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32483397 dopamine receptor D4 [Homo sapiens]                       863   0.0  
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             256   3e-68
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]             256   4e-68
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         243   2e-64
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]           234   8e-62
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]              208   6e-54
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]               206   3e-53
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]               199   4e-51
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   194   1e-49
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  169   4e-42
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               166   3e-41
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s...   156   4e-38
gi|194018562 histamine receptor H3 [Homo sapiens]                     152   5e-37
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   145   9e-35
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]         144   1e-34
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]         143   3e-34
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                135   5e-32
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   129   4e-30
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   129   4e-30
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    129   4e-30
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa...   129   6e-30
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]          127   2e-29
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]         127   2e-29
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]         127   2e-29
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]         127   2e-29
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]         127   2e-29
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]         127   2e-29
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]         127   2e-29
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]         127   2e-29
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                126   4e-29

>gi|32483397 dopamine receptor D4 [Homo sapiens]
          Length = 419

 Score =  863 bits (2229), Expect = 0.0
 Identities = 419/419 (100%), Positives = 419/419 (100%)

Query: 1   MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA 60
           MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
Sbjct: 1   MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA 60

Query: 61  TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT 120
           TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
Sbjct: 61  TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT 120

Query: 121 ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR 180
           ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
Sbjct: 121 ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR 180

Query: 181 DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG 240
           DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
Sbjct: 181 DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG 240

Query: 241 PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG 300
           PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
Sbjct: 241 PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG 300

Query: 301 LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT 360
           LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
Sbjct: 301 LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT 360

Query: 361 PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC 419
           PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Sbjct: 361 PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC 419


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  256 bits (654), Expect = 3e-68
 Identities = 158/398 (39%), Positives = 205/398 (51%), Gaps = 51/398 (12%)

Query: 21  GASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAAD 80
           GA     A  A   A   +    LI A++ GN LVC++V  ERALQT TN  +VSLA AD
Sbjct: 16  GAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVAD 75

Query: 81  LLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVP 140
           LL+A LV+P  VY EV GG W  S   CD  + +DVM+CTASI NLCAIS+DR+ AV +P
Sbjct: 76  LLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMP 135

Query: 141 LRYNR---QGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSS 197
           + Y     Q   RR  L+I A W+L+ AV+ P+L G N     DP VC + + D+V+YSS
Sbjct: 136 VHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT--GDPTVCSISNPDFVIYSS 193

Query: 198 VCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDP 257
           V SF+LP  + +L+Y   +  L++    RR ++  R                        
Sbjct: 194 VVSFYLPFGVTVLVYARIYVVLKQ---RRRKRILTRQ----------------------- 227

Query: 258 CGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVR 317
               C    PG P+    PD A          C  D A   PG      G      +  R
Sbjct: 228 -NSQCNSVRPGFPQQTLSPDPAHLELKRYYSIC-QDTALGGPGF--QERGGELKREEKTR 283

Query: 318 AAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSV 377
            + +P                 RE+KA +++ +V+GAF++CW PFF+ H+    C  C V
Sbjct: 284 NSLMPL----------------REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 327

Query: 378 PPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
            P L SA TWLGYVNSALNPVIYT FN EFR  F K L
Sbjct: 328 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365


>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
          Length = 400

 Score =  256 bits (653), Expect = 4e-68
 Identities = 160/415 (38%), Positives = 212/415 (51%), Gaps = 52/415 (12%)

Query: 21  GASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAAD 80
           GA     A  A   A   +    LI A++ GN LVC++V  ERALQT TN  +VSLA AD
Sbjct: 16  GAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVAD 75

Query: 81  LLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVP 140
           LL+A LV+P  VY EV GG W  S   CD  + +DVM+CTASI NLCAIS+DR+ AV +P
Sbjct: 76  LLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMP 135

Query: 141 LRYNR---QGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSS 197
           + Y     Q   RR  L+I A W+L+ AV+ P+L G N     DP VC + + D+V+YSS
Sbjct: 136 VHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT--GDPTVCSISNPDFVIYSS 193

Query: 198 VCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDP 257
           V SF+LP  + +L+Y   +  L++    RR ++  R                        
Sbjct: 194 VVSFYLPFGVTVLVYARIYVVLKQ---RRRKRILTRQ----------------------- 227

Query: 258 CGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVR 317
               C    PG P+    PD A          C  D A   PG      G      +  R
Sbjct: 228 -NSQCNSVRPGFPQQTLSPDPAHLELKRYYSIC-QDTALGGPGF--QERGGELKREEKTR 283

Query: 318 AAALP---PQTPPQTRRRRRAKITG--------------RERKAMRVLPVVVGAFLLCWT 360
            +  P   P+   + R+    +++               RE+KA +++ +V+GAF++CW 
Sbjct: 284 NSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWL 343

Query: 361 PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
           PFF+ H+    C  C V P L SA TWLGYVNSALNPVIYT FN EFR  F K L
Sbjct: 344 PFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  243 bits (621), Expect = 2e-64
 Identities = 157/387 (40%), Positives = 213/387 (55%), Gaps = 31/387 (8%)

Query: 43  LLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL 102
           LLI  ++ GN LVC++V+ E+ALQT TN  IVSLA ADLL+A LV+P  VY EV G  W 
Sbjct: 43  LLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG-EWK 101

Query: 103 LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYN-RQGGSRRQLLLIGATWL 161
            S   CD  + +DVM+CTASI NLCAIS+DR+ AVA+P+ YN R    RR  ++I   W+
Sbjct: 102 FSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWV 161

Query: 162 LSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQR 221
           LS  ++ P+L GLN+    D   C + +  +VVYSS+ SF++P  + LL+Y   +  L+R
Sbjct: 162 LSFTISCPLLFGLNNA---DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR 218

Query: 222 WEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPA 281
               RR +++ +   R       +P   A R  Q+      +  +P     P     +P 
Sbjct: 219 ----RRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSP-----PERTRYSPI 269

Query: 282 APSLPQ----DPC--GPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRA 335
            PS  Q    DP   G    P +P  P     +  A      A     QT P  + R   
Sbjct: 270 PPSHHQLTLPDPSHHGLHSTPDSPAKPEK---NGHAKDHPKIAKIFEIQTMPNGKTRTSL 326

Query: 336 KITGR-------ERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWL 388
           K   R       E+KA ++L +V+G F++CW PFF+ HI    C  C++PP L SA TWL
Sbjct: 327 KTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWL 385

Query: 389 GYVNSALNPVIYTVFNAEFRNVFRKAL 415
           GYVNSA+NP+IYT FN EFR  F K L
Sbjct: 386 GYVNSAVNPIIYTTFNIEFRKAFLKIL 412


>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
          Length = 443

 Score =  234 bits (598), Expect = 8e-62
 Identities = 159/407 (39%), Positives = 214/407 (52%), Gaps = 42/407 (10%)

Query: 43  LLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL 102
           LLI  ++ GN LVC++V+ E+ALQT TN  IVSLA ADLL+A LV+P  VY EV G  W 
Sbjct: 43  LLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG-EWK 101

Query: 103 LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYN-RQGGSRRQLLLIGATWL 161
            S   CD  + +DVM+CTASI NLCAIS+DR+ AVA+P+ YN R    RR  ++I   W+
Sbjct: 102 FSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWV 161

Query: 162 LSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQR 221
           LS  ++ P+L GLN+    D   C + +  +VVYSS+ SF++P  + LL+Y   +  L+R
Sbjct: 162 LSFTISCPLLFGLNNA---DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR 218

Query: 222 -------WEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGP------DCAPPAPG 268
                     +R  + H RAP + +   P         +  +   P      + A  A  
Sbjct: 219 RRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQE 278

Query: 269 L-------PRGPCGPDCAPAAPSLPQ----DPC--GPDCAPPAPGLPPDPCGSNCAPPDA 315
           L          P     +P  PS  Q    DP   G    P +P  P     +  A    
Sbjct: 279 LEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEK---NGHAKDHP 335

Query: 316 VRAAALPPQTPPQTRRRRRAKITGR-------ERKAMRVLPVVVGAFLLCWTPFFVVHIT 368
             A     QT P  + R   K   R       E+KA ++L +V+G F++CW PFF+ HI 
Sbjct: 336 KIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHIL 395

Query: 369 QALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
              C  C++PP L SA TWLGYVNSA+NP+IYT FN EFR  F K L
Sbjct: 396 NIHCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441


>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
          Length = 465

 Score =  208 bits (530), Expect = 6e-54
 Identities = 164/472 (34%), Positives = 227/472 (48%), Gaps = 89/472 (18%)

Query: 9   ADGLLAGRG---PAAGASAGASAGLAGQGAAAL------------VGGVLLIGAVLAGNS 53
           A+G  A  G   P AG ++       G GA A             + G+L++  V  GN 
Sbjct: 9   AEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVF-GNV 67

Query: 54  LVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMA 113
           LV ++V T RAL+ P N F+VSLA+AD+L+A LV+P  + +EV G  W      C+  +A
Sbjct: 68  LVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLA 126

Query: 114 MDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCG 173
           +DV+ CT+SI +LCAIS+DR+ ++   + YN +   RR   +I   W++SA ++ P L  
Sbjct: 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLIS 186

Query: 174 LNDV---RGRDPAVCRLEDRD---YVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARR 227
           +       G  PA  R E  D   YV+ S + SFF PC +M+L+Y      ++ +++A+R
Sbjct: 187 IEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVY------VRIYQIAKR 240

Query: 228 --------------AKLHGRAPRRPSGPGP------------PSPT-------PPAPRLP 254
                         A   G   RRP+G GP            P PT        PAP  P
Sbjct: 241 RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP 300

Query: 255 QDPCGPDC----------APPAPGLP-RGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPP 303
           +D    D            PP P  P RGP G   A A+   P D   P   P A G+  
Sbjct: 301 RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSL-PRRGPGATGI-- 357

Query: 304 DPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFF 363
              G+  A P   R  A        +R R R     RE++   VL VV+G F++CW PFF
Sbjct: 358 ---GTPAAGPGEERVGA-----AKASRWRGR---QNREKRFTFVLAVVIGVFVVCWFPFF 406

Query: 364 VVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
             +   A+   CSVP  L     W GY NS+LNPVIYT+FN +FR  F+K L
Sbjct: 407 FTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456


>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
          Length = 450

 Score =  206 bits (524), Expect = 3e-53
 Identities = 153/449 (34%), Positives = 222/449 (49%), Gaps = 83/449 (18%)

Query: 33  QGAAALVGGV-LLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLF 91
           Q  AA+   +  LI   + GN+LV ++V T R+L+ P N F+VSLAAAD+L+A L++P  
Sbjct: 10  QATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFS 69

Query: 92  VYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRR 151
           + +E+ G  W      C+  +A+DV+ CT+SI +LCAIS+DR+ AV+  L YN +   RR
Sbjct: 70  LANELLG-YWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRR 128

Query: 152 QLLLIGATWLLSAAVAAPVLCGLND----VRGRDPAVCRL-EDRDYVVYSSVCSFFLPCP 206
              +I   WL++A ++ P L    D     RGR    C+L ++  Y++ SS+ SFF PC 
Sbjct: 129 IKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQ--CKLNQEAWYILASSIGSFFAPCL 186

Query: 207 LMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPA 266
           +M+L+Y      L+ + +A+R+  + R PR   GPG      P P    D  G   +   
Sbjct: 187 IMILVY------LRIYLIAKRS--NRRGPRAKGGPGQGESKQPRP----DHGGALASAKL 234

Query: 267 PGLPRGPCGPDCAPAAPS--------LPQDPCGPDCAPPAPGLPPDP--------CGSN- 309
           P L       +    + S         P+D  G    PP+    P+         CG++ 
Sbjct: 235 PALASVASAREVNGHSKSTGEKEEGETPED-TGTRALPPSWAALPNSGQGQKEGVCGASP 293

Query: 310 ----------------CAP---PDAVRAAALPPQTPPQTRR------------------- 331
                           C P   P +  +A  PP   PQ  R                   
Sbjct: 294 EDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIG 353

Query: 332 ----RRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPA-CSVPPRLVSAVT 386
               RRRA++T RE++   VL VV+G F+LCW PFF  +   A+CP  C VP  L     
Sbjct: 354 GQWWRRRAQLT-REKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFF 412

Query: 387 WLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
           W+GY NS+LNPVIYT+FN +FR  FR+ L
Sbjct: 413 WIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441


>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
          Length = 462

 Score =  199 bits (506), Expect = 4e-51
 Identities = 158/445 (35%), Positives = 213/445 (47%), Gaps = 50/445 (11%)

Query: 2   GNRSTADADGLLAGRGPAAGA-SAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA 60
           G+   A+A G  A  GP  G  SAGA AGLA     A+VG   LI   + GN LV ++V 
Sbjct: 27  GSGGVANASG--ASWGPPRGQYSAGAVAGLA-----AVVG--FLIVFTVVGNVLVVIAVL 77

Query: 61  TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT 120
           T RAL+ P N F+VSLA+AD+L+A LV+P  + +E+    W      C   +A+DV+ CT
Sbjct: 78  TSRALRAPQNLFLVSLASADILVATLVMPFSLANELMA-YWYFGQVWCGVYLALDVLFCT 136

Query: 121 ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGL-NDVRG 179
           +SI +LCAIS+DR+ +V   + YN +   RR    I A WL+SA ++ P L  L     G
Sbjct: 137 SSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDG 196

Query: 180 RDPAVCRLEDRD-YVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRP 238
                C L D   Y++ S + SFF PC +M L+Y   +R     ++  R     RAP  P
Sbjct: 197 AAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVA---KLRTRTLSEKRAPVGP 253

Query: 239 SGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCG------- 291
            G  P +             G  CAPP   +      PD + AA    +           
Sbjct: 254 DGASPTTENGLGAAAGAGENG-HCAPPPADVE-----PDESSAAAERRRRRGALRRGGRR 307

Query: 292 -PDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTR-----------RRRRAKIT- 338
                  A G      G   A   A+ A+  P      +R           RRRRA+ + 
Sbjct: 308 RAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSV 367

Query: 339 -------GRERKAMRVLPVVVGAFLLCWTPFFVVHITQALC-PACSVPPRLVSAVTWLGY 390
                   RE++   VL VV+G F+LCW PFF  +    +C  AC VP  L     W+GY
Sbjct: 368 CRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGY 427

Query: 391 VNSALNPVIYTVFNAEFRNVFRKAL 415
            NS+LNPVIYTVFN +FR  F+  L
Sbjct: 428 CNSSLNPVIYTVFNQDFRRSFKHIL 452


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  194 bits (494), Expect = 1e-49
 Identities = 133/416 (31%), Positives = 204/416 (49%), Gaps = 32/416 (7%)

Query: 18  PAAGASAGASAGLAG-----QGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSF 72
           PA   + G + G++      Q   +L+ G L+  AVL GN+ V  ++A ER+LQ   N  
Sbjct: 16  PAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVL-GNACVVAAIALERSLQNVANYL 74

Query: 73  IVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVD 132
           I SLA  DL++++LVLP+    +V    W L    CD  +A+DV+ CT+SI +LCAI++D
Sbjct: 75  IGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTSSILHLCAIALD 133

Query: 133 RFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR-DPAVCRL-EDR 190
           R+ A+  P+ Y  +   RR   LI  TWL+   ++ P + G      R DP  C + +D 
Sbjct: 134 RYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH 193

Query: 191 DYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPA 250
            Y +YS+  +F++P  LML+LY   FR   R+ + +  K         +G        PA
Sbjct: 194 GYTIYSTFGAFYIPLLLMLVLYGRIFRA-ARFRIRKTVK-----KVEKTGADTRHGASPA 247

Query: 251 PRLPQDPCGPDCAPP-APGLPRGPCGPDCAPAAPSLPQDPCGPDC--------APPAPGL 301
           P+  +   G   +     G+     G  CA  A     D    +         +     L
Sbjct: 248 PQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPL 307

Query: 302 PPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTP 361
           P +   + CAP    R          +    +R     RERK ++ L +++G F+LCW P
Sbjct: 308 PSEAGPTPCAPASFER-------KNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP 360

Query: 362 FFVVHITQALC-PACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALR 416
           FF+V +    C  +C +P  L + + WLGY NS LNPVIY  FN +F+N F+K ++
Sbjct: 361 FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIK 416


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  169 bits (428), Expect = 4e-42
 Identities = 133/388 (34%), Positives = 190/388 (48%), Gaps = 72/388 (18%)

Query: 43  LLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL 102
           L++  ++AGN LV V++A    LQT TN FI+SLA+ADL++ LLV+P F  + V  G W 
Sbjct: 67  LIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVP-FGATIVVWGRWE 125

Query: 103 LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLL 162
                C+   ++DV+  TASI  LC I++DR++A+  P RY       R   L+   W +
Sbjct: 126 YGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAI 185

Query: 163 SAAVA-APVLC----GLNDVRGR---DPAVCR-LEDRDYVVYSSVCSFFLPCPLMLLLYW 213
           SA V+  P+L       +D   R   DP  C  + +R Y + SSV SF++P  +M  +Y 
Sbjct: 186 SALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYL 245

Query: 214 ATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTP-PAPRLPQDPCGPDCAPPAPGLPRG 272
             FR  Q+ +V +      R    P+ P  PSP+P PAP           APP PG PR 
Sbjct: 246 RVFREAQK-QVKKIDSCERRFLGGPARPPSPSPSPVPAP-----------APP-PGPPR- 291

Query: 273 PCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRR 332
                  PAA                                   AAA  P    +  +R
Sbjct: 292 -------PAA-----------------------------------AAATAPLANGRAGKR 309

Query: 333 RRAKITG-RERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYV 391
           R +++   RE+KA++ L +++G F LCW PFF+ ++ +A      VP RL     WLGY 
Sbjct: 310 RPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-VPDRLFVFFNWLGYA 368

Query: 392 NSALNPVIYTVFNAEFRNVFRKALRACC 419
           NSA NP+IY   + +FR  F+  L  CC
Sbjct: 369 NSAFNPIIY-CRSPDFRKAFQGLL--CC 393


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  166 bits (421), Expect = 3e-41
 Identities = 141/414 (34%), Positives = 192/414 (46%), Gaps = 81/414 (19%)

Query: 18  PAAGASAGASAGLAGQGAAALVGGVLLIGAVLA---GNSLVCVSVATERALQTPTNSFIV 74
           P    +   ++GL G    A + G LL  AVLA   GN LV V++A    LQT TN F+ 
Sbjct: 18  PTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVT 77

Query: 75  SLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRF 134
           SLAAADL++ LLV+P      + G  W L    C+   ++DV+  TASI  LCA++VDR+
Sbjct: 78  SLAAADLVMGLLVVPPAATLALTGH-WPLGATGCELWTSVDVLCVTASIETLCALAVDRY 136

Query: 135 VAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVA-APVL-----CGLNDVRGR---DPAVC 185
           +AV  PLRY      R     +   W++SAAV+ AP++      G +    R   +P  C
Sbjct: 137 LAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCC 196

Query: 186 RL-EDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPP 244
               +  YV+ SS  SF+LP  +ML +Y   F       VA R     R  R   G  PP
Sbjct: 197 AFASNMPYVLLSSSVSFYLPLLVMLFVYARVF------VVATRQL---RLLRGELGRFPP 247

Query: 245 SPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPD 304
             +PPAP                              + SL   P G  CAPP  G+P  
Sbjct: 248 EESPPAP------------------------------SRSLAPAPVG-TCAPP-EGVP-- 273

Query: 305 PCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFV 364
            CG                       RR    +  RE +A+  L +++G F LCW PFF+
Sbjct: 274 ACG-----------------------RRPARLLPLREHRALCTLGLIMGTFTLCWLPFFL 310

Query: 365 VHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRAC 418
            ++ +AL     VP     A+ WLGY NSA NP+IY   + +FR+ FR+ L  C
Sbjct: 311 ANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY-CRSPDFRSAFRRLLCRC 363


>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
           sapiens]
          Length = 481

 Score =  156 bits (394), Expect = 4e-38
 Identities = 111/386 (28%), Positives = 183/386 (47%), Gaps = 60/386 (15%)

Query: 35  AAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYS 94
           AA L+  +++I   + GN+LV ++V+ E+ LQ  TN F++SLA ADLL+ L V+P+ + +
Sbjct: 57  AALLI--LMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLT 114

Query: 95  EVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLL 154
            +    W L   LC A + +DV+  TASI +LCAISVDR++A+  P++ N+        +
Sbjct: 115 IMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFI 174

Query: 155 LIGATWLLSAAVAAPV-LCGL-NDVRGRDPAVCRLEDR---DYVVYSSVCSFFLPCPLML 209
            I   WL+S  +A PV + G+  DV   +   C L      D++++ S+ +FF P  +M+
Sbjct: 175 KITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMI 234

Query: 210 LLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGL 269
           + Y+ T   LQ+    +   +  + P+R +            +  + PC           
Sbjct: 235 VTYFLTIHALQK----KAYLVKNKPPQRLTW----LTVSTVFQRDETPCS---------- 276

Query: 270 PRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQT 329
                                 P+      G   D    N      +R  +   +   QT
Sbjct: 277 ---------------------SPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQT 315

Query: 330 --RRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPAC--SVPPRLVSAV 385
               +R +K+ G          +V   FLL W PFF+ +IT  LC +C  +    L+   
Sbjct: 316 ISNEQRASKVLG----------IVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIF 365

Query: 386 TWLGYVNSALNPVIYTVFNAEFRNVF 411
            W+GYV+S +NP++YT+FN  FR+ F
Sbjct: 366 VWIGYVSSGVNPLVYTLFNKTFRDAF 391


>gi|194018562 histamine receptor H3 [Homo sapiens]
          Length = 445

 Score =  152 bits (384), Expect = 5e-37
 Identities = 119/427 (27%), Positives = 191/427 (44%), Gaps = 29/427 (6%)

Query: 8   DADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQT 67
           +A G LAG   AAG + G SA      AA +    LLI A + GN+LV ++   + +L+T
Sbjct: 11  NASGALAGEAAAAGGARGFSAAWTAVLAALMA---LLIVATVLGNALVMLAFVADSSLRT 67

Query: 68  PTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLC 127
             N F+++LA +D L+    +PL+V   V  G W     LC   + +D +LCT+S FN+ 
Sbjct: 68  QNNFFLLNLAISDFLVGAFCIPLYV-PYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIV 126

Query: 128 AISVDRFVAVAVPLRYN-RQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAV-- 184
            IS DRF++V   + Y  +QG +RR +  +   W+L+  +  P +     + G       
Sbjct: 127 LISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEG 186

Query: 185 -CRLE---DRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG 240
            C  E   +  +++ +S   FF P   +     + +  +QR     R +L     R  +G
Sbjct: 187 HCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQR-----RTRLRLDGAREAAG 241

Query: 241 PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG 300
           P PP    P+P  P    G         +P    G   A       +   G      +  
Sbjct: 242 PEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVA 301

Query: 301 LPPDPCGSNCAP---PDAVRAAALPPQTPPQTRRR---------RRAKITGRERKAMRVL 348
            P    GS+      P +++  + P  +     +R         +R +++ R+RK  + L
Sbjct: 302 SPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLS-RDRKVAKSL 360

Query: 349 PVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFR 408
            V+V  F LCW P+ ++ I +A C    VP        WL + NSA+NPV+Y + +  FR
Sbjct: 361 AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR 420

Query: 409 NVFRKAL 415
             F K L
Sbjct: 421 RAFTKLL 427


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  145 bits (365), Expect = 9e-35
 Identities = 104/380 (27%), Positives = 166/380 (43%), Gaps = 52/380 (13%)

Query: 43  LLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL 102
           L+  A    N+ V  +V   R L TP N  I SLA  DLL+++LV+P+     V G  W 
Sbjct: 58  LITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTG-RWT 116

Query: 103 LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLL 162
           L   +CD  ++ D+  CTASI +LC I++DR+ A+   + Y+ +   +R  ++I   W+ 
Sbjct: 117 LGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVF 176

Query: 163 SAAVAAPVLCGLNDVRGRDPAVCRLEDRD--YVVYSSVCSFFLPCPLMLLLYWATFRGLQ 220
           S +++ P           + + C +      Y VYS+V +F+ P  L++ LY   +    
Sbjct: 177 SISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIY---- 232

Query: 221 RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAP 280
              V  R+++  + P R              RL +     D              P    
Sbjct: 233 ---VEARSRILKQTPNR-----------TGKRLTRAQLITD-------------SPGSTS 265

Query: 281 AAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGR 340
           +  S+          P  P     P   N      V  A L  +     R R+  K  G 
Sbjct: 266 SVTSINSR------VPDVPSESGSPVYVNQVKV-RVSDALLEKKKLMAARERKATKTLG- 317

Query: 341 ERKAMRVLPVVVGAFLLCWTPFFVVHITQALC-PACSVPPRLVSAVTWLGYVNSALNPVI 399
                    +++GAF++CW PFF++ +   +C  AC     +    TWLGY+NS +NP+I
Sbjct: 318 ---------IILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPII 368

Query: 400 YTVFNAEFRNVFRKALRACC 419
           YT+ N +F+  F K +R  C
Sbjct: 369 YTMSNEDFKQAFHKLIRFKC 388


>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
          Length = 479

 Score =  144 bits (363), Expect = 1e-34
 Identities = 115/444 (25%), Positives = 181/444 (40%), Gaps = 75/444 (16%)

Query: 36  AALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSE 95
           A + G + L+  V  GN LV +S+   R LQT  N F+ SLA ADL++    + L+    
Sbjct: 36  ATVTGSLSLVTVV--GNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYI 93

Query: 96  VQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLL 155
           ++G  W L   +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   L+
Sbjct: 94  IKG-YWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLM 152

Query: 156 IGATWLLSAAVAAPVL------CGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLML 209
           I A W+LS  + AP +       G   V      +  L +      +++ +F+LP  +M 
Sbjct: 153 IAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMT 212

Query: 210 LLYWATFRGLQRWEVARRAKLHGRAPRRP------------------------------- 238
           +LY           +A R+++H   P  P                               
Sbjct: 213 VLY-------IHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAARE 265

Query: 239 --------SGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCA---PAAPSLPQ 287
                     P P  P PP P   +D      +  A    +     + +      P++P 
Sbjct: 266 ELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPA 325

Query: 288 DPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRR---------------- 331
            P  P    PA         +     + V A  + P TP   R                 
Sbjct: 326 PPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQV 385

Query: 332 RRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYV 391
           R++ ++  RERK  R +  ++ AF+L WTP+ V+ +    C +C +P  + S   WL YV
Sbjct: 386 RKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPDTVWSIGYWLCYV 444

Query: 392 NSALNPVIYTVFNAEFRNVFRKAL 415
           NS +NP  Y + NA F+  FR  L
Sbjct: 445 NSTINPACYALCNATFKKTFRHLL 468


>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
          Length = 460

 Score =  143 bits (361), Expect = 3e-34
 Identities = 121/433 (27%), Positives = 178/433 (41%), Gaps = 44/433 (10%)

Query: 12  LLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNS 71
           L  G+GP   A  G + GL             L  A + GN LV +S      L+T  N 
Sbjct: 16  LAPGKGPWQVAFIGITTGL-------------LSLATVTGNLLVLISFKVNTELKTVNNY 62

Query: 72  FIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISV 131
           F++SLA ADL++    + L+  + +  G W L    CD  +A+D +   AS+ NL  IS 
Sbjct: 63  FLLSLACADLIIGTFSMNLYT-TYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISF 121

Query: 132 DRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPV------LCGLNDVRGRDPAVC 185
           DR+ +V  PL Y  +   RR  L+IG  WL+S  + AP       L G   V      + 
Sbjct: 122 DRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQ 181

Query: 186 RLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPS 245
            L        +++ +F+LP  +M  LYW  +R  +       A      P +  G    S
Sbjct: 182 FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSS 241

Query: 246 --PTPPAPRLPQDPCGPDC-APPAPGLPRGPCGPD-------CAPAAPSLPQDPCGPDCA 295
               P A   P+ P G  C    AP L +     +          +  S   +  G +  
Sbjct: 242 ERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVV 301

Query: 296 PPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITG-------------RER 342
              P + P+       PP +       P    + R  +  K  G             +E+
Sbjct: 302 IKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEK 361

Query: 343 KAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTV 402
           KA R L  ++ AF+L WTP+ ++ +    C  C VP  L     WL YVNS +NP+ Y +
Sbjct: 362 KAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTINPMCYAL 420

Query: 403 FNAEFRNVFRKAL 415
            N  FR+ FR  L
Sbjct: 421 CNKAFRDTFRLLL 433


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  135 bits (341), Expect = 5e-32
 Identities = 83/211 (39%), Positives = 113/211 (53%), Gaps = 2/211 (0%)

Query: 3   NRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATE 62
           NRS+A   G     G   G +A     ++ QG    V     I   +AGN LV +SVA  
Sbjct: 65  NRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACN 124

Query: 63  RALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTAS 122
           R LQT TN FIV+LA ADLLL+  VLP     EV  G W      CD   A+DV+ CTAS
Sbjct: 125 RHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVL-GFWAFGRAFCDVWAAVDVLCCTAS 183

Query: 123 IFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDP 182
           I +LC ISVDR+V V   L+Y      R+   ++   W+++  V+   L G  +    D 
Sbjct: 184 ILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDE 243

Query: 183 AVCRL-EDRDYVVYSSVCSFFLPCPLMLLLY 212
             C + E+  Y V+SSVCSF+LP  +++++Y
Sbjct: 244 RFCGITEEAGYAVFSSVCSFYLPMAVIVVMY 274



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 34/80 (42%), Positives = 46/80 (57%)

Query: 340 RERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVI 399
           RE+KA + L +VVG F+LCW PFF V    +L P       +   + WLGY NS +NP+I
Sbjct: 342 REKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLI 401

Query: 400 YTVFNAEFRNVFRKALRACC 419
           Y   + EF+  F + LR  C
Sbjct: 402 YPCSSREFKRAFLRLLRCQC 421


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  129 bits (325), Expect = 4e-30
 Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 2/192 (1%)

Query: 32  GQGAAALVGGVLLIGAVL--AGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLP 89
           G+    ++G +L +  +L  AGN LV +SV   + L+ P+N  IVSLA ADL +A+ V+P
Sbjct: 77  GRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMP 136

Query: 90  LFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGS 149
               +++ GG W+     C+  +AMDVM CTASI  LC IS+DR++ +  PL Y  +   
Sbjct: 137 FVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG 196

Query: 150 RRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLML 209
           +    +I + WLLSA++  P L G       D      +D  Y +YS+  +F++P  +ML
Sbjct: 197 KCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVML 256

Query: 210 LLYWATFRGLQR 221
            +Y+  ++  ++
Sbjct: 257 FMYYQIYKAARK 268



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 36/88 (40%), Positives = 50/88 (56%), Gaps = 3/88 (3%)

Query: 332 RRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQA-LC-PACSVPPRLVS-AVTWL 388
           R+   I  RE+KA   L ++VGAF +CW PFF++   +  +C  +CS  P  V     WL
Sbjct: 313 RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWL 372

Query: 389 GYVNSALNPVIYTVFNAEFRNVFRKALR 416
           GY NS +NP IY  FN + R  +R  L+
Sbjct: 373 GYANSLINPFIYAFFNRDLRTTYRSLLQ 400


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  129 bits (325), Expect = 4e-30
 Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 2/192 (1%)

Query: 32  GQGAAALVGGVLLIGAVL--AGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLP 89
           G+    ++G +L +  +L  AGN LV +SV   + L+ P+N  IVSLA ADL +A+ V+P
Sbjct: 77  GRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMP 136

Query: 90  LFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGS 149
               +++ GG W+     C+  +AMDVM CTASI  LC IS+DR++ +  PL Y  +   
Sbjct: 137 FVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG 196

Query: 150 RRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLML 209
           +    +I + WLLSA++  P L G       D      +D  Y +YS+  +F++P  +ML
Sbjct: 197 KCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVML 256

Query: 210 LLYWATFRGLQR 221
            +Y+  ++  ++
Sbjct: 257 FMYYQIYKAARK 268



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 36/88 (40%), Positives = 50/88 (56%), Gaps = 3/88 (3%)

Query: 332 RRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQA-LC-PACSVPPRLVS-AVTWL 388
           R+   I  RE+KA   L ++VGAF +CW PFF++   +  +C  +CS  P  V     WL
Sbjct: 313 RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWL 372

Query: 389 GYVNSALNPVIYTVFNAEFRNVFRKALR 416
           GY NS +NP IY  FN + R  +R  L+
Sbjct: 373 GYANSLINPFIYAFFNRDLRTTYRSLLQ 400


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  129 bits (325), Expect = 4e-30
 Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 2/192 (1%)

Query: 32  GQGAAALVGGVLLIGAVL--AGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLP 89
           G+    ++G +L +  +L  AGN LV +SV   + L+ P+N  IVSLA ADL +A+ V+P
Sbjct: 77  GRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMP 136

Query: 90  LFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGS 149
               +++ GG W+     C+  +AMDVM CTASI  LC IS+DR++ +  PL Y  +   
Sbjct: 137 FVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG 196

Query: 150 RRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLML 209
           +    +I + WLLSA++  P L G       D      +D  Y +YS+  +F++P  +ML
Sbjct: 197 KCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVML 256

Query: 210 LLYWATFRGLQR 221
            +Y+  ++  ++
Sbjct: 257 FMYYQIYKAARK 268



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 36/88 (40%), Positives = 50/88 (56%), Gaps = 3/88 (3%)

Query: 332 RRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQA-LC-PACSVPPRLVS-AVTWL 388
           R+   I  RE+KA   L ++VGAF +CW PFF++   +  +C  +CS  P  V     WL
Sbjct: 313 RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWL 372

Query: 389 GYVNSALNPVIYTVFNAEFRNVFRKALR 416
           GY NS +NP IY  FN + R  +R  L+
Sbjct: 373 GYANSLINPFIYAFFNRDLRTTYRSLLQ 400


>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
           sapiens]
          Length = 471

 Score =  129 bits (323), Expect = 6e-30
 Identities = 71/188 (37%), Positives = 117/188 (62%), Gaps = 3/188 (1%)

Query: 36  AALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSE 95
           +AL+  V++I   +AGN LV ++V+ E+ LQ  TN F++SLA AD+LL  LV+P+ + + 
Sbjct: 77  SALLTAVVII-LTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTI 135

Query: 96  VQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLL 155
           + G  W L  +LC   + +DV+  TASI +LCAIS+DR+VA+  P+ ++R     +  L 
Sbjct: 136 LYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195

Query: 156 IGATWLLSAAVAAPV-LCGL-NDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYW 213
           I A W +S  ++ P+ + GL +D +      C L D ++V+  S  SFF+P  +M++ Y+
Sbjct: 196 IIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYF 255

Query: 214 ATFRGLQR 221
            T + LQ+
Sbjct: 256 LTIKSLQK 263



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 31/88 (35%), Positives = 56/88 (63%), Gaps = 3/88 (3%)

Query: 332 RRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCP-ACS--VPPRLVSAVTWL 388
           RR  +    E+KA +VL +V   F++ W PFF+ +I   +C  +C+  V   L++   W+
Sbjct: 309 RRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWI 368

Query: 389 GYVNSALNPVIYTVFNAEFRNVFRKALR 416
           GY++SA+NP++YT+FN  +R+ F + ++
Sbjct: 369 GYLSSAVNPLVYTLFNKTYRSAFSRYIQ 396


>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86

Query: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145

Query: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205

Query: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265

Query: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325

Query: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385

Query: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444

Query: 405 AEFRNVFRKAL 415
           A F+  F+  L
Sbjct: 445 ATFKKTFKHLL 455


>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86

Query: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145

Query: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205

Query: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265

Query: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325

Query: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385

Query: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444

Query: 405 AEFRNVFRKAL 415
           A F+  F+  L
Sbjct: 445 ATFKKTFKHLL 455


>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86

Query: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145

Query: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205

Query: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265

Query: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325

Query: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385

Query: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444

Query: 405 AEFRNVFRKAL 415
           A F+  F+  L
Sbjct: 445 ATFKKTFKHLL 455


>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86

Query: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145

Query: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205

Query: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265

Query: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325

Query: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385

Query: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444

Query: 405 AEFRNVFRKAL 415
           A F+  F+  L
Sbjct: 445 ATFKKTFKHLL 455


>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86

Query: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145

Query: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205

Query: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265

Query: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325

Query: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385

Query: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444

Query: 405 AEFRNVFRKAL 415
           A F+  F+  L
Sbjct: 445 ATFKKTFKHLL 455


>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86

Query: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145

Query: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205

Query: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265

Query: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325

Query: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385

Query: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444

Query: 405 AEFRNVFRKAL 415
           A F+  F+  L
Sbjct: 445 ATFKKTFKHLL 455


>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86

Query: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145

Query: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205

Query: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265

Query: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325

Query: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385

Query: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444

Query: 405 AEFRNVFRKAL 415
           A F+  F+  L
Sbjct: 445 ATFKKTFKHLL 455


>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86

Query: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145

Query: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205

Query: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265

Query: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325

Query: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385

Query: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444

Query: 405 AEFRNVFRKAL 415
           A F+  F+  L
Sbjct: 445 ATFKKTFKHLL 455


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  126 bits (316), Expect = 4e-29
 Identities = 73/179 (40%), Positives = 109/179 (60%), Gaps = 3/179 (1%)

Query: 35  AAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYS 94
           +  LV G  ++ A++ GN LV +SVA  R L+TPTN FIV+LA ADLLL+  VLP     
Sbjct: 47  SVGLVLGAFILFAIV-GNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAAL 105

Query: 95  EVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLL 154
           EV G  W+L    CD   A+DV+ CTASI +LCAIS+DR++ V   L+Y      R+ +L
Sbjct: 106 EVLG-YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAIL 164

Query: 155 LIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRL-EDRDYVVYSSVCSFFLPCPLMLLLY 212
            + + W+LS  ++   L G  +    D   C + E+  Y ++SS+ SF++P  ++L++Y
Sbjct: 165 ALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMY 223



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 34/80 (42%), Positives = 45/80 (56%)

Query: 340 RERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVI 399
           RE+KA + L +VVG F+LCW PFF+     +L      P  +   V WLGY NS LNP+I
Sbjct: 288 REKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPII 347

Query: 400 YTVFNAEFRNVFRKALRACC 419
           Y   + EF+  F + L   C
Sbjct: 348 YPCSSKEFKRAFVRILGCQC 367


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.457 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,523,198
Number of Sequences: 37866
Number of extensions: 1355018
Number of successful extensions: 33204
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 823
Number of HSP's successfully gapped in prelim test: 1707
Number of HSP's that attempted gapping in prelim test: 14483
Number of HSP's gapped (non-prelim): 11274
length of query: 419
length of database: 18,247,518
effective HSP length: 105
effective length of query: 314
effective length of database: 14,271,588
effective search space: 4481278632
effective search space used: 4481278632
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.