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Search of human proteins with 32455269
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32455269 serine/threonine kinase 32C [Homo sapiens]
(486 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32455269 serine/threonine kinase 32C [Homo sapiens] 989 0.0
gi|8923754 serine/threonine kinase 32B [Homo sapiens] 562 e-160
gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens] 516 e-146
gi|21450709 serine/threonine kinase 32A isoform 2 [Homo sapiens] 265 5e-71
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 197 2e-50
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 196 5e-50
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 196 5e-50
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 192 4e-49
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 192 4e-49
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 190 3e-48
gi|62241015 AKT1 kinase [Homo sapiens] 187 1e-47
gi|62241013 AKT1 kinase [Homo sapiens] 187 1e-47
gi|62241011 AKT1 kinase [Homo sapiens] 187 1e-47
gi|133908623 protein kinase C, iota [Homo sapiens] 187 2e-47
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 183 3e-46
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 183 3e-46
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 183 3e-46
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 181 1e-45
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 179 7e-45
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 179 7e-45
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 178 9e-45
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 178 1e-44
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 178 1e-44
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 177 1e-44
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 177 1e-44
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 177 1e-44
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 177 1e-44
gi|28557781 protein kinase C, eta [Homo sapiens] 177 2e-44
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 176 4e-44
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 176 4e-44
>gi|32455269 serine/threonine kinase 32C [Homo sapiens]
Length = 486
Score = 989 bits (2557), Expect = 0.0
Identities = 486/486 (100%), Positives = 486/486 (100%)
Query: 1 MRSGAERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQ 60
MRSGAERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQ
Sbjct: 1 MRSGAERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQ 60
Query: 61 WSKWKKRMGSSMSAATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYA 120
WSKWKKRMGSSMSAATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYA
Sbjct: 61 WSKWKKRMGSSMSAATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYA 120
Query: 121 MKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRY 180
MKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRY
Sbjct: 121 MKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRY 180
Query: 181 HLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATI 240
HLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATI
Sbjct: 181 HLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATI 240
Query: 241 IKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSS 300
IKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSS
Sbjct: 241 IKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSS 300
Query: 301 NAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDH 360
NAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDH
Sbjct: 301 NAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDH 360
Query: 361 LSEKRVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSEND 420
LSEKRVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSEND
Sbjct: 361 LSEKRVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSEND 420
Query: 421 YLQDCLDAIQQDFVIFNREKLKRSQDLPREPLPAPESRDAAEPVEDEAERSALPMCGPIC 480
YLQDCLDAIQQDFVIFNREKLKRSQDLPREPLPAPESRDAAEPVEDEAERSALPMCGPIC
Sbjct: 421 YLQDCLDAIQQDFVIFNREKLKRSQDLPREPLPAPESRDAAEPVEDEAERSALPMCGPIC 480
Query: 481 PSAGSG 486
PSAGSG
Sbjct: 481 PSAGSG 486
>gi|8923754 serine/threonine kinase 32B [Homo sapiens]
Length = 414
Score = 562 bits (1449), Expect = e-160
Identities = 262/366 (71%), Positives = 315/366 (86%), Gaps = 1/366 (0%)
Query: 80 PVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVF 139
PVFD+ E+VNFDHFQILRAIGKGSFGKVCIVQKRDT+KMYAMKYMNKQ+CIERDEVRNVF
Sbjct: 10 PVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVF 69
Query: 140 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 199
REL+I+Q +EH FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV F+E TV+LYICE
Sbjct: 70 RELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICE 129
Query: 200 MALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAP 259
+ALAL+YL+ HIIHRD+KPDNILLDE GH H+TDFNIAT++K ERA+++AGTKPYMAP
Sbjct: 130 LALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAP 189
Query: 260 EIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVP 319
E+F +++ G GYS+ VDWWS+G+ AYELLRGWRPY+IHS ++ ++ +F V Y
Sbjct: 190 EVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSS 249
Query: 320 TWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGRLHC 379
TW K MVALLRKLLT +PE R+SSL D+Q+ P LA + WD + +K + PGFVPNKGRL+C
Sbjct: 250 TWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLNC 309
Query: 380 DPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQQDFVIFNRE 439
DPTFELEEMILES+PLHKKKKRLAKN+SRD ++DS N +LQ CL+ ++++F+IFNRE
Sbjct: 310 DPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPL-NGHLQHCLETVREEFIIFNRE 368
Query: 440 KLKRSQ 445
KL+R Q
Sbjct: 369 KLRRQQ 374
>gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]
Length = 396
Score = 516 bits (1328), Expect = e-146
Identities = 256/394 (64%), Positives = 308/394 (78%), Gaps = 10/394 (2%)
Query: 72 MSAATARRP-VFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCI 130
M A T+R+P VFD+ EDVNFDHF+ILRAIGKGSFGKVCIVQK DT+KMYAMKYMNKQ+C+
Sbjct: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
Query: 131 ERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSE 190
ER+EVRNVF+EL+I+Q +EH FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV F E
Sbjct: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
Query: 191 DTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATAL 250
+TV+L+ICE+ +ALDYL+ Q IIHRD+KPDNILLDE GH H+TDFNIA ++ + T +
Sbjct: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM 180
Query: 251 AGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLF 310
AGTKPYMAPE+F S G GYSF VDWWS+GV AYELLRG RPY I SS + + +V F
Sbjct: 181 AGTKPYMAPEMFSS--RKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTF 238
Query: 311 STVSVQYVPTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGF 370
T V Y WS+EMV+LL+KLL NP+ R S L DVQ P + + WD + +KR+ PGF
Sbjct: 239 ETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGF 298
Query: 371 VPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQ 430
+PNKGRL+CDPTFELEEMILES+PLHKKKKRLAK + DSSQ+ LQ+ LD++Q
Sbjct: 299 IPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKKEKDMRKCDSSQT--CLLQEHLDSVQ 356
Query: 431 QDFVIFNREKL-----KRSQDLPREPLPAPESRD 459
++F+IFNREK+ KR +L E P+ D
Sbjct: 357 KEFIIFNREKVNRDFNKRQPNLALEQTKDPQGED 390
>gi|21450709 serine/threonine kinase 32A isoform 2 [Homo sapiens]
Length = 166
Score = 265 bits (678), Expect = 5e-71
Identities = 125/156 (80%), Positives = 144/156 (92%), Gaps = 1/156 (0%)
Query: 72 MSAATARRP-VFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCI 130
M A T+R+P VFD+ EDVNFDHF+ILRAIGKGSFGKVCIVQK DT+KMYAMKYMNKQ+C+
Sbjct: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
Query: 131 ERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSE 190
ER+EVRNVF+EL+I+Q +EH FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV F E
Sbjct: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
Query: 191 DTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDE 226
+TV+L+ICE+ +ALDYL+ Q IIHRD+KPDNILLDE
Sbjct: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDE 156
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 197 bits (500), Expect = 2e-50
Identities = 112/290 (38%), Positives = 172/290 (59%), Gaps = 15/290 (5%)
Query: 93 FQILRAIGKGSFGKVCIVQKR---DTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIE 149
F++L+ +G+GSFGKV +V+K+ D ++YAMK + K RD VR E +IL E+
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-ERDILVEVN 131
Query: 150 HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRG 209
H F+V L Y+FQ E +++++D L GGD+ L + V F+E+ V+ Y+ E+ALALD+L
Sbjct: 132 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 191
Query: 210 QHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEIFHSFVNG 268
I++RD+KP+NILLDE GH LTDF ++ D E +A + GT YMAPE+ +
Sbjct: 192 LGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR---- 247
Query: 269 GTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVAL 328
G+S DWWS GV+ +E+L G P+ N +++ Q++ S E +L
Sbjct: 248 -RGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFL---SAEAQSL 303
Query: 329 LRKLLTVNPEHRLSS--LQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGR 376
LR L NP +RL S +++++ A + WD L ++ V+P F P G+
Sbjct: 304 LRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 353
Score = 82.8 bits (203), Expect = 6e-16
Identities = 65/212 (30%), Positives = 106/212 (50%), Gaps = 24/212 (11%)
Query: 93 FQILRAIGKGSFG--KVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEI-E 149
+++ IG GS+ K CI + E +A+K ++K + R+ E+EIL +
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNME--FAVKIIDKSK-------RDPSEEIEILMRYGQ 476
Query: 150 HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRG 209
H ++ L F D +++V DL+ GG+L + + FSE + ++ +DYL
Sbjct: 477 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHC 536
Query: 210 QHIIHRDVKPDNIL-LDERGHA---HLTDFNIATIIKDGERATALAG--TKPYMAPEIFH 263
Q ++HRD+KP NIL +DE A + DF A ++ GE L T ++APE+
Sbjct: 537 QGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLR-GENGLLLTPCYTANFVAPEVLM 595
Query: 264 SFVNGGTGYSFEVDWWSVGVMAYELLRGWRPY 295
GY D WS+GV+ Y +L G+ P+
Sbjct: 596 Q-----QGYDAACDIWSLGVLFYTMLAGYTPF 622
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 196 bits (497), Expect = 5e-50
Identities = 115/310 (37%), Positives = 176/310 (56%), Gaps = 21/310 (6%)
Query: 86 EDVNFDHFQILRAIGKGSFGKVCIVQK---RDTEKMYAMKYMNKQQCIERDEVRNVFREL 142
E + F++L+ +G+GS+GKV +V+K D ++YAMK + K RD VR+ E
Sbjct: 60 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ER 118
Query: 143 EILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMAL 202
+IL E+ H F+V L Y+FQ E +++++D L GGDL L + V F+E+ V+ Y+ E+AL
Sbjct: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178
Query: 203 ALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEI 261
ALD+L II+RD+KP+NILLDE GH +TDF ++ I +RA + GT YMAPE+
Sbjct: 179 ALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 238
Query: 262 FHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTW 321
+ G++ DWWS GV+ +E+L G P+ +L+ Q++
Sbjct: 239 VNR-----RGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFL--- 290
Query: 322 SKEMVALLRKLLTVNPEHRLSS----LQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGR- 376
S E +LLR L NP +RL + +++++ P + W+ L K ++P F P GR
Sbjct: 291 SGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRP 350
Query: 377 ---LHCDPTF 383
H DP F
Sbjct: 351 EDTFHFDPEF 360
Score = 96.3 bits (238), Expect = 6e-20
Identities = 75/267 (28%), Positives = 131/267 (49%), Gaps = 26/267 (9%)
Query: 91 DHFQILRAIGKGSFG--KVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEI 148
D ++I IG GS+ K C+ + DTE YA+K ++K + R+ E+EIL
Sbjct: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTE--YAVKIIDKSK-------RDPSEEIEILLRY 471
Query: 149 -EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYL 207
+H ++ L + D + +++V++L+ GG+L + + FSE +C + +DYL
Sbjct: 472 GQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYL 531
Query: 208 RGQHIIHRDVKPDNILL-DERG---HAHLTDFNIATIIKDGERATAL-AGTKPYMAPEIF 262
Q ++HRD+KP NIL DE G + DF A ++ G T ++APE+
Sbjct: 532 HSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVL 591
Query: 263 HSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFST----VSVQYV 318
GY D WS+G++ Y +L G+ P+ + E ++ + +S
Sbjct: 592 KR-----QGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNW 646
Query: 319 PTWSKEMVALLRKLLTVNPEHRLSSLQ 345
+ S ++ K+L V+P RL+++Q
Sbjct: 647 DSISDAAKDVVSKMLHVDPHQRLTAMQ 673
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 196 bits (497), Expect = 5e-50
Identities = 115/310 (37%), Positives = 176/310 (56%), Gaps = 21/310 (6%)
Query: 86 EDVNFDHFQILRAIGKGSFGKVCIVQK---RDTEKMYAMKYMNKQQCIERDEVRNVFREL 142
E + F++L+ +G+GS+GKV +V+K D ++YAMK + K RD VR+ E
Sbjct: 52 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ER 110
Query: 143 EILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMAL 202
+IL E+ H F+V L Y+FQ E +++++D L GGDL L + V F+E+ V+ Y+ E+AL
Sbjct: 111 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 170
Query: 203 ALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEI 261
ALD+L II+RD+KP+NILLDE GH +TDF ++ I +RA + GT YMAPE+
Sbjct: 171 ALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 230
Query: 262 FHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTW 321
+ G++ DWWS GV+ +E+L G P+ +L+ Q++
Sbjct: 231 VNR-----RGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFL--- 282
Query: 322 SKEMVALLRKLLTVNPEHRLSS----LQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGR- 376
S E +LLR L NP +RL + +++++ P + W+ L K ++P F P GR
Sbjct: 283 SGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRP 342
Query: 377 ---LHCDPTF 383
H DP F
Sbjct: 343 EDTFHFDPEF 352
Score = 96.3 bits (238), Expect = 6e-20
Identities = 75/267 (28%), Positives = 131/267 (49%), Gaps = 26/267 (9%)
Query: 91 DHFQILRAIGKGSFG--KVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEI 148
D ++I IG GS+ K C+ + DTE YA+K ++K + R+ E+EIL
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTE--YAVKIIDKSK-------RDPSEEIEILLRY 463
Query: 149 -EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYL 207
+H ++ L + D + +++V++L+ GG+L + + FSE +C + +DYL
Sbjct: 464 GQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYL 523
Query: 208 RGQHIIHRDVKPDNILL-DERG---HAHLTDFNIATIIKDGERATAL-AGTKPYMAPEIF 262
Q ++HRD+KP NIL DE G + DF A ++ G T ++APE+
Sbjct: 524 HSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVL 583
Query: 263 HSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFST----VSVQYV 318
GY D WS+G++ Y +L G+ P+ + E ++ + +S
Sbjct: 584 KR-----QGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNW 638
Query: 319 PTWSKEMVALLRKLLTVNPEHRLSSLQ 345
+ S ++ K+L V+P RL+++Q
Sbjct: 639 DSISDAAKDVVSKMLHVDPHQRLTAMQ 665
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 192 bits (489), Expect = 4e-49
Identities = 121/360 (33%), Positives = 185/360 (51%), Gaps = 38/360 (10%)
Query: 21 PGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQWSKWKKRMGSSMSAATARRP 80
P + RP S +P P +G R D G ++ +
Sbjct: 20 PRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKE---------------------ISITHH 58
Query: 81 VFDDKEDVNFDHFQILRAIGKGSFGKVCIVQK---RDTEKMYAMKYMNKQQCIERDEVRN 137
V E + HF++L+ +G+GSFGKV +V+K D+ +YAMK + K RD VR
Sbjct: 59 VKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRT 118
Query: 138 VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 197
E +IL ++ H F+V L Y+FQ E +++++D L GGDL L + V F+E+ V+ Y+
Sbjct: 119 KM-ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 177
Query: 198 CEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGE-RATALAGTKPY 256
E+AL LD+L II+RD+KP+NILLDE GH LTDF ++ D E +A + GT Y
Sbjct: 178 AELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEY 237
Query: 257 MAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQ 316
MAPE+ + G+S DWWS GV+ +E+L G P+ +L+ Q
Sbjct: 238 MAPEVVNR-----QGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ 292
Query: 317 YVPTWSKEMVALLRKLLTVNPEHRLSS----LQDVQAAPALAGVLWDHLSEKRVEPGFVP 372
++ T E +LLR L NP +RL S ++++ + + W+ L + ++P F P
Sbjct: 293 FLST---EAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 349
Score = 92.0 bits (227), Expect = 1e-18
Identities = 72/268 (26%), Positives = 129/268 (48%), Gaps = 22/268 (8%)
Query: 91 DHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEI-E 149
D + + IG GS+ + + T YA+K ++K + R+ E+EIL +
Sbjct: 425 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK-------RDPSEEIEILLRYGQ 477
Query: 150 HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRG 209
H ++ L + D + +++V +L+ GG+L + + FSE + + ++YL
Sbjct: 478 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 537
Query: 210 QHIIHRDVKPDNIL-LDERGH---AHLTDFNIATIIK-DGERATALAGTKPYMAPEIFHS 264
Q ++HRD+KP NIL +DE G+ + DF A ++ + T ++APE+
Sbjct: 538 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR 597
Query: 265 FVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFS----TVSVQYVPT 320
GY D WS+G++ Y +L G+ P+ S+ E ++ T+S T
Sbjct: 598 -----QGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNT 652
Query: 321 WSKEMVALLRKLLTVNPEHRLSSLQDVQ 348
S+ L+ K+L V+P RL++ Q +Q
Sbjct: 653 VSETAKDLVSKMLHVDPHQRLTAKQVLQ 680
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 192 bits (489), Expect = 4e-49
Identities = 114/315 (36%), Positives = 176/315 (55%), Gaps = 21/315 (6%)
Query: 81 VFDDKEDVNFDHFQILRAIGKGSFGKVCIVQK---RDTEKMYAMKYMNKQQCIERDEVRN 137
V + E + F++L+ +G+GSFGKV +V+K D ++YAMK + K RD VR
Sbjct: 56 VKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRT 115
Query: 138 VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 197
E +IL E+ H F+V L Y+FQ E +++++D L GGDL L + V F+E+ V+ Y+
Sbjct: 116 KM-ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 174
Query: 198 CEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGE-RATALAGTKPY 256
E+ALALD+L II+RD+KP+NILLDE GH LTDF ++ D E +A + GT Y
Sbjct: 175 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEY 234
Query: 257 MAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQ 316
MAPE+ + G++ DWWS GV+ +E+L G P+ +++ Q
Sbjct: 235 MAPEVVNR-----RGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQ 289
Query: 317 YVPTWSKEMVALLRKLLTVNPEHRLSS----LQDVQAAPALAGVLWDHLSEKRVEPGFVP 372
++ S E +LLR L NP +RL + +++++ + + W+ L + + P F P
Sbjct: 290 FL---SPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP 346
Query: 373 NKGR----LHCDPTF 383
GR + DP F
Sbjct: 347 ATGRPEDTFYFDPEF 361
Score = 86.7 bits (213), Expect = 4e-17
Identities = 78/295 (26%), Positives = 141/295 (47%), Gaps = 29/295 (9%)
Query: 91 DHFQILRAIGKGSFG--KVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEI 148
D +++ IG GS+ K CI + + E +A+K ++K + R+ E+EIL
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCIHKATNME--FAVKIIDKSK-------RDPTEEIEILLRY 470
Query: 149 -EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYL 207
+H ++ L + D + +++V +L+ GG+L + + FSE + + ++YL
Sbjct: 471 GQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYL 530
Query: 208 RGQHIIHRDVKPDNIL-LDERGH---AHLTDFNIATIIK-DGERATALAGTKPYMAPEIF 262
Q ++HRD+KP NIL +DE G+ + DF A ++ + T ++APE+
Sbjct: 531 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 590
Query: 263 HSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFS----TVSVQYV 318
GY D WS+GV+ Y +L G+ P+ + E ++ ++S Y
Sbjct: 591 KR-----QGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYW 645
Query: 319 PTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGFVPN 373
+ S L+ K+L V+P RL++ V P + V WD L + ++ P+
Sbjct: 646 NSVSDTAKDLVSKMLHVDPHQRLTAAL-VLRHPWI--VHWDQLPQYQLNRQDAPH 697
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 190 bits (482), Expect = 3e-48
Identities = 110/295 (37%), Positives = 168/295 (56%), Gaps = 17/295 (5%)
Query: 86 EDVNFDHFQILRAIGKGSFGKVCIVQK---RDTEKMYAMKYMNKQQCIERDEVRNVFREL 142
E + HF++L+ +G+GSFGKV +V+K D+ +YAMK + K RD VR E
Sbjct: 55 EKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ER 113
Query: 143 EILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMAL 202
+IL ++ H F+V L Y+FQ E +++++D L GGDL L + V F+E+ V+ Y+ E+AL
Sbjct: 114 DILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 173
Query: 203 ALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEI 261
LD+L II+RD+KP+NILLDE GH LTDF ++ D E +A + GT YMAPE+
Sbjct: 174 GLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEV 233
Query: 262 FHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTW 321
+ G+S DWWS GV+ +E+L G P+ +L+ Q++ T
Sbjct: 234 VNR-----QGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLST- 287
Query: 322 SKEMVALLRKLLTVNPEHRLSS----LQDVQAAPALAGVLWDHLSEKRVEPGFVP 372
E +LLR L NP +RL S ++++ + + W+ L + ++P F P
Sbjct: 288 --EAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 340
Score = 92.0 bits (227), Expect = 1e-18
Identities = 72/268 (26%), Positives = 129/268 (48%), Gaps = 22/268 (8%)
Query: 91 DHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEI-E 149
D + + IG GS+ + + T YA+K ++K + R+ E+EIL +
Sbjct: 416 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK-------RDPSEEIEILLRYGQ 468
Query: 150 HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRG 209
H ++ L + D + +++V +L+ GG+L + + FSE + + ++YL
Sbjct: 469 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 528
Query: 210 QHIIHRDVKPDNIL-LDERGH---AHLTDFNIATIIK-DGERATALAGTKPYMAPEIFHS 264
Q ++HRD+KP NIL +DE G+ + DF A ++ + T ++APE+
Sbjct: 529 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR 588
Query: 265 FVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFS----TVSVQYVPT 320
GY D WS+G++ Y +L G+ P+ S+ E ++ T+S T
Sbjct: 589 -----QGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNT 643
Query: 321 WSKEMVALLRKLLTVNPEHRLSSLQDVQ 348
S+ L+ K+L V+P RL++ Q +Q
Sbjct: 644 VSETAKDLVSKMLHVDPHQRLTAKQVLQ 671
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 187 bits (476), Expect = 1e-47
Identities = 103/294 (35%), Positives = 162/294 (55%), Gaps = 14/294 (4%)
Query: 85 KEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEI 144
K V + F+ L+ +GKG+FGKV +V+++ T + YAMK + K+ + +DEV + E +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 145 LQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALAL 204
LQ H FL L YSFQ + + V++ GG+L +HL + FSED R Y E+ AL
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 205 DYLRGQ-HIIHRDVKPDNILLDERGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIF 262
DYL + ++++RD+K +N++LD+ GH +TDF + IKDG GT Y+APE+
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 263 HSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWS 322
Y VDWW +GV+ YE++ G P+ + E L +L +++ T
Sbjct: 322 ED-----NDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLG 373
Query: 323 KEMVALLRKLLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVP 372
E +LL LL +P+ RL +++ AG++W H+ EK++ P F P
Sbjct: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 187 bits (476), Expect = 1e-47
Identities = 103/294 (35%), Positives = 162/294 (55%), Gaps = 14/294 (4%)
Query: 85 KEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEI 144
K V + F+ L+ +GKG+FGKV +V+++ T + YAMK + K+ + +DEV + E +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 145 LQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALAL 204
LQ H FL L YSFQ + + V++ GG+L +HL + FSED R Y E+ AL
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 205 DYLRGQ-HIIHRDVKPDNILLDERGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIF 262
DYL + ++++RD+K +N++LD+ GH +TDF + IKDG GT Y+APE+
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 263 HSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWS 322
Y VDWW +GV+ YE++ G P+ + E L +L +++ T
Sbjct: 322 ED-----NDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLG 373
Query: 323 KEMVALLRKLLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVP 372
E +LL LL +P+ RL +++ AG++W H+ EK++ P F P
Sbjct: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 187 bits (476), Expect = 1e-47
Identities = 103/294 (35%), Positives = 162/294 (55%), Gaps = 14/294 (4%)
Query: 85 KEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEI 144
K V + F+ L+ +GKG+FGKV +V+++ T + YAMK + K+ + +DEV + E +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 145 LQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALAL 204
LQ H FL L YSFQ + + V++ GG+L +HL + FSED R Y E+ AL
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 205 DYLRGQ-HIIHRDVKPDNILLDERGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIF 262
DYL + ++++RD+K +N++LD+ GH +TDF + IKDG GT Y+APE+
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 263 HSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWS 322
Y VDWW +GV+ YE++ G P+ + E L +L +++ T
Sbjct: 322 ED-----NDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLG 373
Query: 323 KEMVALLRKLLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVP 372
E +LL LL +P+ RL +++ AG++W H+ EK++ P F P
Sbjct: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 187 bits (475), Expect = 2e-47
Identities = 102/294 (34%), Positives = 166/294 (56%), Gaps = 18/294 (6%)
Query: 93 FQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIE-HV 151
F +LR IG+GS+ KV +V+ + T+++YAMK + K+ + +++ V E + ++ H
Sbjct: 254 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 313
Query: 152 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQH 211
FLV L FQ E +F V++ + GGDL +H+Q+ + E+ R Y E++LAL+YL +
Sbjct: 314 FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG 373
Query: 212 IIHRDVKPDNILLDERGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSFVNGGT 270
II+RD+K DN+LLD GH LTD+ + ++ G+ + GT Y+APEI G
Sbjct: 374 IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR-----GE 428
Query: 271 GYSFEVDWWSVGVMAYELLRGWRPYDIHSS------NAVESLVQLFSTVSVQYVPTWSKE 324
Y F VDWW++GV+ +E++ G P+DI S N + L Q+ ++ + S +
Sbjct: 429 DYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVK 488
Query: 325 MVALLRKLLTVNPEHRL-----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVPN 373
++L+ L +P+ RL + D+Q P V WD + +K+V P F PN
Sbjct: 489 AASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 183 bits (464), Expect = 3e-46
Identities = 97/311 (31%), Positives = 170/311 (54%), Gaps = 12/311 (3%)
Query: 84 DKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELE 143
+++ V + F+ R +GKG FG+VC Q R T KMYA K + K++ +R E
Sbjct: 178 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR 237
Query: 144 ILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRLYICEMA 201
IL++++ F+V+L Y+++ ++ + +V+ ++ GGDL++H+ N F E Y E+
Sbjct: 238 ILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELC 297
Query: 202 LALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEI 261
L+ L+ + I++RD+KP+NILLD+RGH ++D +AT I +G+R GT YMAPE+
Sbjct: 298 CGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV 357
Query: 262 FHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAV-ESLVQLFSTVSVQYVPT 320
++ Y+F DWW +G + YE+++G P+ + E + Q + +Y
Sbjct: 358 VNN-----EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412
Query: 321 WSKEMVALLRKLLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGR 376
+S++ ++ R LLT NP RL V+ P + + L +EP F P+
Sbjct: 413 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 472
Query: 377 LHCDPTFELEE 387
++C ++E+
Sbjct: 473 VYCKDVLDIEQ 483
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 183 bits (464), Expect = 3e-46
Identities = 97/311 (31%), Positives = 170/311 (54%), Gaps = 12/311 (3%)
Query: 84 DKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELE 143
+++ V + F+ R +GKG FG+VC Q R T KMYA K + K++ +R E
Sbjct: 146 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR 205
Query: 144 ILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRLYICEMA 201
IL++++ F+V+L Y+++ ++ + +V+ ++ GGDL++H+ N F E Y E+
Sbjct: 206 ILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELC 265
Query: 202 LALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEI 261
L+ L+ + I++RD+KP+NILLD+RGH ++D +AT I +G+R GT YMAPE+
Sbjct: 266 CGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV 325
Query: 262 FHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAV-ESLVQLFSTVSVQYVPT 320
++ Y+F DWW +G + YE+++G P+ + E + Q + +Y
Sbjct: 326 VNN-----EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 380
Query: 321 WSKEMVALLRKLLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGR 376
+S++ ++ R LLT NP RL V+ P + + L +EP F P+
Sbjct: 381 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 440
Query: 377 LHCDPTFELEE 387
++C ++E+
Sbjct: 441 VYCKDVLDIEQ 451
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 183 bits (464), Expect = 3e-46
Identities = 97/311 (31%), Positives = 170/311 (54%), Gaps = 12/311 (3%)
Query: 84 DKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELE 143
+++ V + F+ R +GKG FG+VC Q R T KMYA K + K++ +R E
Sbjct: 178 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR 237
Query: 144 ILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRLYICEMA 201
IL++++ F+V+L Y+++ ++ + +V+ ++ GGDL++H+ N F E Y E+
Sbjct: 238 ILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELC 297
Query: 202 LALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEI 261
L+ L+ + I++RD+KP+NILLD+RGH ++D +AT I +G+R GT YMAPE+
Sbjct: 298 CGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV 357
Query: 262 FHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAV-ESLVQLFSTVSVQYVPT 320
++ Y+F DWW +G + YE+++G P+ + E + Q + +Y
Sbjct: 358 VNN-----EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412
Query: 321 WSKEMVALLRKLLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGR 376
+S++ ++ R LLT NP RL V+ P + + L +EP F P+
Sbjct: 413 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 472
Query: 377 LHCDPTFELEE 387
++C ++E+
Sbjct: 473 VYCKDVLDIEQ 483
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 181 bits (460), Expect = 1e-45
Identities = 102/286 (35%), Positives = 168/286 (58%), Gaps = 14/286 (4%)
Query: 91 DHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEH 150
D F+ LR +G GSFG+V +V+ ++T YAMK +NKQ+ ++ +V ++ E ILQ I+
Sbjct: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101
Query: 151 VFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQ 210
FLV L +SF+D +++V++ + GG++ LQ+ +FSE Y ++ LA+ YL
Sbjct: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSL 161
Query: 211 HIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGT 270
+IHRD+KP+N+L+D++G+ +TDF A +K R L GT Y+APEI S
Sbjct: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILS-----K 214
Query: 271 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLR 330
GY+ VDWW++GV+ YE+ G+ P+ ++ ++ ++ S V++ S ++ LLR
Sbjct: 215 GYNKAVDWWALGVLIYEMAVGFPPF--YADQPIQIYEKIVSG-RVRFPSKLSSDLKHLLR 271
Query: 331 KLLTVNPEHRLSSLQ----DVQAAPALAGVLWDHLSEKRVEPGFVP 372
LL V+ R +L+ D++ A W + EK+VE F+P
Sbjct: 272 SLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIP 317
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 179 bits (453), Expect = 7e-45
Identities = 95/291 (32%), Positives = 169/291 (58%), Gaps = 20/291 (6%)
Query: 89 NFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEI 148
+ D F+ ++ +G GSFG+V +V+ ++T YAMK ++KQ+ ++ ++ + E ILQ +
Sbjct: 32 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 91
Query: 149 EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLR 208
FLV L +SF+D +++MV++ + GG++ HL++ +FSE R Y ++ L +YL
Sbjct: 92 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 151
Query: 209 GQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNG 268
+I+RD+KP+N+L+D++G+ +TDF A +K R L GT Y+APEI S
Sbjct: 152 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILS---- 205
Query: 269 GTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTV---SVQYVPTWSKEM 325
GY+ VDWW++GV+ YE+ G+ P+ + +Q++ + V++ +S ++
Sbjct: 206 -KGYNKAVDWWALGVLIYEMAAGYPPF------FADQPIQIYEKIVSGKVRFPSHFSSDL 258
Query: 326 VALLRKLLTVNPEHRLSSLQ----DVQAAPALAGVLWDHLSEKRVEPGFVP 372
LLR LL V+ R +L+ D++ A W + +++VE F+P
Sbjct: 259 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 309
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 179 bits (453), Expect = 7e-45
Identities = 95/291 (32%), Positives = 169/291 (58%), Gaps = 20/291 (6%)
Query: 89 NFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEI 148
+ D F+ ++ +G GSFG+V +V+ ++T YAMK ++KQ+ ++ ++ + E ILQ +
Sbjct: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 99
Query: 149 EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLR 208
FLV L +SF+D +++MV++ + GG++ HL++ +FSE R Y ++ L +YL
Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159
Query: 209 GQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNG 268
+I+RD+KP+N+L+D++G+ +TDF A +K R L GT Y+APEI S
Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILS---- 213
Query: 269 GTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTV---SVQYVPTWSKEM 325
GY+ VDWW++GV+ YE+ G+ P+ + +Q++ + V++ +S ++
Sbjct: 214 -KGYNKAVDWWALGVLIYEMAAGYPPF------FADQPIQIYEKIVSGKVRFPSHFSSDL 266
Query: 326 VALLRKLLTVNPEHRLSSLQ----DVQAAPALAGVLWDHLSEKRVEPGFVP 372
LLR LL V+ R +L+ D++ A W + +++VE F+P
Sbjct: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 178 bits (452), Expect = 9e-45
Identities = 101/305 (33%), Positives = 166/305 (54%), Gaps = 12/305 (3%)
Query: 88 VNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRE---LEI 144
+ + F + R IG+G FG+V +K DT KMYAMK ++K++ + E L +
Sbjct: 186 LTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
Query: 145 LQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALAL 204
+ + F+V + Y+F + + ++DL+ GGDL YHL Q+ FSE +R Y E+ L L
Sbjct: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
Query: 205 DYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHS 264
+++ + +++RD+KP NILLDE GHA ++D +A ++ A GT YMAPE+
Sbjct: 306 EHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHASVGTHGYMAPEVLQK 364
Query: 265 FVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKE 324
GT Y DW+S+G M ++LLRG P+ H + + ++ TV+V+ T+S E
Sbjct: 365 ----GTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE 420
Query: 325 MVALLRKLLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGRLHCD 380
+ +LL LL + RL Q+V+ GV W H+ ++ P +P +G ++
Sbjct: 421 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA 480
Query: 381 PTFEL 385
F++
Sbjct: 481 DAFDI 485
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 178 bits (451), Expect = 1e-44
Identities = 95/295 (32%), Positives = 169/295 (57%), Gaps = 20/295 (6%)
Query: 85 KEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEI 144
+ + + F+ + +G GSFG+V +V+ + TE+ YAMK ++KQ+ ++ ++ + E I
Sbjct: 36 QNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRI 95
Query: 145 LQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALAL 204
LQ + FLV L Y+F+D +++MV++ + GG++ HL++ +FSE R Y ++ L
Sbjct: 96 LQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155
Query: 205 DYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHS 264
+YL +I+RD+KP+N+L+D +G+ +TDF A +K R L GT Y+APEI S
Sbjct: 156 EYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILS 213
Query: 265 FVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTV---SVQYVPTW 321
GY+ VDWW++GV+ YE+ G+ P+ + +Q++ + V++ +
Sbjct: 214 -----KGYNKAVDWWALGVLIYEMAAGYPPF------FADQPIQIYEKIVSGKVRFPSHF 262
Query: 322 SKEMVALLRKLLTVNPEHRLSSLQ----DVQAAPALAGVLWDHLSEKRVEPGFVP 372
S ++ LLR LL V+ R +L+ D++ A W + +++VE F+P
Sbjct: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 317
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 178 bits (451), Expect = 1e-44
Identities = 95/295 (32%), Positives = 169/295 (57%), Gaps = 20/295 (6%)
Query: 85 KEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEI 144
+ + + F+ + +G GSFG+V +V+ + TE+ YAMK ++KQ+ ++ ++ + E I
Sbjct: 83 QNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRI 142
Query: 145 LQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALAL 204
LQ + FLV L Y+F+D +++MV++ + GG++ HL++ +FSE R Y ++ L
Sbjct: 143 LQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 202
Query: 205 DYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHS 264
+YL +I+RD+KP+N+L+D +G+ +TDF A +K R L GT Y+APEI S
Sbjct: 203 EYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILS 260
Query: 265 FVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTV---SVQYVPTW 321
GY+ VDWW++GV+ YE+ G+ P+ + +Q++ + V++ +
Sbjct: 261 -----KGYNKAVDWWALGVLIYEMAAGYPPF------FADQPIQIYEKIVSGKVRFPSHF 309
Query: 322 SKEMVALLRKLLTVNPEHRLSSLQ----DVQAAPALAGVLWDHLSEKRVEPGFVP 372
S ++ LLR LL V+ R +L+ D++ A W + +++VE F+P
Sbjct: 310 SSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 364
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 177 bits (450), Expect = 1e-44
Identities = 106/303 (34%), Positives = 161/303 (53%), Gaps = 17/303 (5%)
Query: 93 FQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHV 151
F L+ IGKGSFGKV + + + E YA+K + K+ +++ E +++ E +L + ++H
Sbjct: 98 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP 157
Query: 152 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQH 211
FLV L +SFQ + ++ V+D + GG+L YHLQ+ F E R Y E+A AL YL +
Sbjct: 158 FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN 217
Query: 212 IIHRDVKPDNILLDERGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEIFHSFVNGGT 270
I++RD+KP+NILLD +GH LTDF + I+ + GT Y+APE+ H
Sbjct: 218 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK-----Q 272
Query: 271 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLR 330
Y VDWW +G + YE+L G P+ +S N E + + +Q P + LL
Sbjct: 273 PYDRTVDWWCLGAVLYEMLYGLPPF--YSRNTAEMYDNILNK-PLQLKPNITNSARHLLE 329
Query: 331 KLLTVNPEHRLSSLQD---VQAAPALAGVLWDHLSEKRVEPGFVPN----KGRLHCDPTF 383
LL + RL + D +++ + + WD L K++ P F PN H DP F
Sbjct: 330 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 389
Query: 384 ELE 386
E
Sbjct: 390 TEE 392
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 177 bits (450), Expect = 1e-44
Identities = 106/303 (34%), Positives = 161/303 (53%), Gaps = 17/303 (5%)
Query: 93 FQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHV 151
F L+ IGKGSFGKV + + + E YA+K + K+ +++ E +++ E +L + ++H
Sbjct: 112 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP 171
Query: 152 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQH 211
FLV L +SFQ + ++ V+D + GG+L YHLQ+ F E R Y E+A AL YL +
Sbjct: 172 FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN 231
Query: 212 IIHRDVKPDNILLDERGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEIFHSFVNGGT 270
I++RD+KP+NILLD +GH LTDF + I+ + GT Y+APE+ H
Sbjct: 232 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK-----Q 286
Query: 271 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLR 330
Y VDWW +G + YE+L G P+ +S N E + + +Q P + LL
Sbjct: 287 PYDRTVDWWCLGAVLYEMLYGLPPF--YSRNTAEMYDNILNK-PLQLKPNITNSARHLLE 343
Query: 331 KLLTVNPEHRLSSLQD---VQAAPALAGVLWDHLSEKRVEPGFVPN----KGRLHCDPTF 383
LL + RL + D +++ + + WD L K++ P F PN H DP F
Sbjct: 344 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 403
Query: 384 ELE 386
E
Sbjct: 404 TEE 406
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 177 bits (450), Expect = 1e-44
Identities = 106/303 (34%), Positives = 161/303 (53%), Gaps = 17/303 (5%)
Query: 93 FQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHV 151
F L+ IGKGSFGKV + + + E YA+K + K+ +++ E +++ E +L + ++H
Sbjct: 126 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP 185
Query: 152 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQH 211
FLV L +SFQ + ++ V+D + GG+L YHLQ+ F E R Y E+A AL YL +
Sbjct: 186 FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN 245
Query: 212 IIHRDVKPDNILLDERGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEIFHSFVNGGT 270
I++RD+KP+NILLD +GH LTDF + I+ + GT Y+APE+ H
Sbjct: 246 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK-----Q 300
Query: 271 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLR 330
Y VDWW +G + YE+L G P+ +S N E + + +Q P + LL
Sbjct: 301 PYDRTVDWWCLGAVLYEMLYGLPPF--YSRNTAEMYDNILNK-PLQLKPNITNSARHLLE 357
Query: 331 KLLTVNPEHRLSSLQD---VQAAPALAGVLWDHLSEKRVEPGFVPN----KGRLHCDPTF 383
LL + RL + D +++ + + WD L K++ P F PN H DP F
Sbjct: 358 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 417
Query: 384 ELE 386
E
Sbjct: 418 TEE 420
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 177 bits (450), Expect = 1e-44
Identities = 106/303 (34%), Positives = 161/303 (53%), Gaps = 17/303 (5%)
Query: 93 FQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHV 151
F L+ IGKGSFGKV + + + E YA+K + K+ +++ E +++ E +L + ++H
Sbjct: 193 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP 252
Query: 152 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQH 211
FLV L +SFQ + ++ V+D + GG+L YHLQ+ F E R Y E+A AL YL +
Sbjct: 253 FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN 312
Query: 212 IIHRDVKPDNILLDERGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEIFHSFVNGGT 270
I++RD+KP+NILLD +GH LTDF + I+ + GT Y+APE+ H
Sbjct: 313 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK-----Q 367
Query: 271 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLR 330
Y VDWW +G + YE+L G P+ +S N E + + +Q P + LL
Sbjct: 368 PYDRTVDWWCLGAVLYEMLYGLPPF--YSRNTAEMYDNILNK-PLQLKPNITNSARHLLE 424
Query: 331 KLLTVNPEHRLSSLQD---VQAAPALAGVLWDHLSEKRVEPGFVPN----KGRLHCDPTF 383
LL + RL + D +++ + + WD L K++ P F PN H DP F
Sbjct: 425 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 484
Query: 384 ELE 386
E
Sbjct: 485 TEE 487
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 177 bits (449), Expect = 2e-44
Identities = 108/315 (34%), Positives = 166/315 (52%), Gaps = 21/315 (6%)
Query: 88 VNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQE 147
+ D+F+ +R +GKGSFGKV + + ++T +YA+K + K ++ D+V E IL
Sbjct: 350 LGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSL 409
Query: 148 IE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDY 206
H FL L+ FQ + +F V++ + GGDL +H+Q++ +F E R Y E+ AL +
Sbjct: 410 ARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMF 469
Query: 207 LRGQHIIHRDVKPDNILLDERGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSF 265
L + II+RD+K DN+LLD GH L DF + I +G GT Y+APEI
Sbjct: 470 LHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM 529
Query: 266 VNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTW-SKE 324
+ Y VDWW++GV+ YE+L G P++ + + L + V Y PTW ++
Sbjct: 530 L-----YGPAVDWWAMGVLLYEMLCGHAPFEAENE---DDLFEAILNDEVVY-PTWLHED 580
Query: 325 MVALLRKLLTVNPEHRLSSLQD-----VQAAPALAGVLWDHLSEKRVEPGFVPN-KGR-- 376
+L+ +T NP RL SL + P + W L+ +++EP F P K R
Sbjct: 581 ATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSRED 640
Query: 377 -LHCDPTFELEEMIL 390
+ DP F EE +L
Sbjct: 641 VSNFDPDFIKEEPVL 655
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 176 bits (446), Expect = 4e-44
Identities = 98/285 (34%), Positives = 155/285 (54%), Gaps = 13/285 (4%)
Query: 93 FQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVF 152
F L+ +GKG+FGKV +V+++ + K YAMK + K+ I +DEV + E +L+ H F
Sbjct: 148 FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207
Query: 153 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQHI 212
L +L YSFQ ++ + V++ + GG+L +HL + FSED R Y E+ ALDYL I
Sbjct: 208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI 267
Query: 213 IHRDVKPDNILLDERGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSFVNGGTG 271
++RD+K +N++LD+ GH +TDF + I D GT Y+APE+
Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED-----ND 322
Query: 272 YSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRK 331
Y VDWW +GV+ YE++ G P+ + E L +L +++ T S + +LL
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSG 379
Query: 332 LLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVP 372
LL +P RL +++ +GV W + +K++ P F P
Sbjct: 380 LLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 176 bits (446), Expect = 4e-44
Identities = 98/285 (34%), Positives = 155/285 (54%), Gaps = 13/285 (4%)
Query: 93 FQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVF 152
F L+ +GKG+FGKV +V+++ + K YAMK + K+ I +DEV + E +L+ H F
Sbjct: 148 FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207
Query: 153 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQHI 212
L +L YSFQ ++ + V++ + GG+L +HL + FSED R Y E+ ALDYL I
Sbjct: 208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI 267
Query: 213 IHRDVKPDNILLDERGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSFVNGGTG 271
++RD+K +N++LD+ GH +TDF + I D GT Y+APE+
Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED-----ND 322
Query: 272 YSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRK 331
Y VDWW +GV+ YE++ G P+ + E L +L +++ T S + +LL
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSG 379
Query: 332 LLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEPGFVP 372
LL +P RL +++ +GV W + +K++ P F P
Sbjct: 380 LLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,610,320
Number of Sequences: 37866
Number of extensions: 1071501
Number of successful extensions: 12361
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 724
Number of HSP's successfully gapped in prelim test: 363
Number of HSP's that attempted gapping in prelim test: 9148
Number of HSP's gapped (non-prelim): 2152
length of query: 486
length of database: 18,247,518
effective HSP length: 106
effective length of query: 380
effective length of database: 14,233,722
effective search space: 5408814360
effective search space used: 5408814360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.