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Search of human proteins with 31982906
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31982906 cingulin-like 1 [Homo sapiens]
(1302 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31982906 cingulin-like 1 [Homo sapiens] 2531 0.0
gi|16262452 cingulin [Homo sapiens] 468 e-131
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 264 4e-70
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 264 4e-70
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 264 4e-70
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 264 4e-70
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 262 1e-69
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 261 2e-69
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 216 1e-55
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 216 1e-55
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 216 1e-55
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 195 2e-49
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 192 2e-48
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 192 2e-48
gi|156104908 myosin heavy chain 6 [Homo sapiens] 191 3e-48
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 191 4e-48
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 190 9e-48
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 188 3e-47
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 186 1e-46
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 186 2e-46
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 176 1e-43
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 170 7e-42
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 155 2e-37
gi|148746195 trichohyalin [Homo sapiens] 153 9e-37
gi|28416946 myosin 18A isoform a [Homo sapiens] 150 8e-36
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 148 3e-35
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 147 5e-35
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 147 5e-35
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 147 5e-35
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 147 5e-35
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 2531 bits (6561), Expect = 0.0
Identities = 1302/1302 (100%), Positives = 1302/1302 (100%)
Query: 1 MELYFGEYQHVQQEYGVHLRLASDDTQKSRSSQNSKAGSYGVSIRVQGIDGHPYIVLNNT 60
MELYFGEYQHVQQEYGVHLRLASDDTQKSRSSQNSKAGSYGVSIRVQGIDGHPYIVLNNT
Sbjct: 1 MELYFGEYQHVQQEYGVHLRLASDDTQKSRSSQNSKAGSYGVSIRVQGIDGHPYIVLNNT 60
Query: 61 ERCLAGTSFSENGPPFPPPVINNLPLHSSNGSVPKENSEELQLPENPYAQPSPIRNLKQP 120
ERCLAGTSFSENGPPFPPPVINNLPLHSSNGSVPKENSEELQLPENPYAQPSPIRNLKQP
Sbjct: 61 ERCLAGTSFSENGPPFPPPVINNLPLHSSNGSVPKENSEELQLPENPYAQPSPIRNLKQP 120
Query: 121 LLHEGKNGVLDRKDGSVKPSHLLNFQRHPELLQPYDPEKNELNLQNHQPSESNWLKTLTE 180
LLHEGKNGVLDRKDGSVKPSHLLNFQRHPELLQPYDPEKNELNLQNHQPSESNWLKTLTE
Sbjct: 121 LLHEGKNGVLDRKDGSVKPSHLLNFQRHPELLQPYDPEKNELNLQNHQPSESNWLKTLTE 180
Query: 181 EGINNKKPWTCFPKPSNSQPTSPSLEDPAKSGVTAIRLCSSVVIEDPKKQTSVCVNVQSC 240
EGINNKKPWTCFPKPSNSQPTSPSLEDPAKSGVTAIRLCSSVVIEDPKKQTSVCVNVQSC
Sbjct: 181 EGINNKKPWTCFPKPSNSQPTSPSLEDPAKSGVTAIRLCSSVVIEDPKKQTSVCVNVQSC 240
Query: 241 TKERVGEEALFTSGRPLTAHSPHAHPETKKTRPDVLPFRRQDSAGPVLDGARSRRSSSSS 300
TKERVGEEALFTSGRPLTAHSPHAHPETKKTRPDVLPFRRQDSAGPVLDGARSRRSSSSS
Sbjct: 241 TKERVGEEALFTSGRPLTAHSPHAHPETKKTRPDVLPFRRQDSAGPVLDGARSRRSSSSS 300
Query: 301 TTPTSANSLYRFLLDDQECAIHADNVNRHENRRYIPFLPGTGRDIDTGSIPGVDQLIEKF 360
TTPTSANSLYRFLLDDQECAIHADNVNRHENRRYIPFLPGTGRDIDTGSIPGVDQLIEKF
Sbjct: 301 TTPTSANSLYRFLLDDQECAIHADNVNRHENRRYIPFLPGTGRDIDTGSIPGVDQLIEKF 360
Query: 361 DQKPGLQRRGRSGKRNRINTDDRKRSRSVDSAFPFGLQGNSEYLIEFSRNLGKSSEHLLR 420
DQKPGLQRRGRSGKRNRINTDDRKRSRSVDSAFPFGLQGNSEYLIEFSRNLGKSSEHLLR
Sbjct: 361 DQKPGLQRRGRSGKRNRINTDDRKRSRSVDSAFPFGLQGNSEYLIEFSRNLGKSSEHLLR 420
Query: 421 PSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQEST 480
PSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQEST
Sbjct: 421 PSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQEST 480
Query: 481 VIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLL 540
VIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLL
Sbjct: 481 VIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLL 540
Query: 541 KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNN 600
KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNN
Sbjct: 541 KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNN 600
Query: 601 QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE 660
QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE
Sbjct: 601 QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE 660
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS 720
KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS 720
Query: 721 EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDK 780
EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDK
Sbjct: 721 EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDK 780
Query: 781 LKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE 840
LKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE
Sbjct: 781 LKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE 840
Query: 841 LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE
Sbjct: 841 LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
Query: 901 LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960
LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI
Sbjct: 901 LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960
Query: 961 VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE 1020
VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE
Sbjct: 961 VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE 1020
Query: 1021 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE
Sbjct: 1021 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
Query: 1081 RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY 1140
RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY
Sbjct: 1081 RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY 1140
Query: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ 1200
RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ 1200
Query: 1201 KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLK
Sbjct: 1201 KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
Query: 1261 KLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKDSTVASQI 1302
KLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKDSTVASQI
Sbjct: 1261 KLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKDSTVASQI 1302
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 468 bits (1203), Expect = e-131
Identities = 280/741 (37%), Positives = 464/741 (62%), Gaps = 16/741 (2%)
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG--NN 600
Q +L E AK++L L E ++ + K + E+ L+ R + +G
Sbjct: 449 QNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV--EEQLRLRERELTALKGALKE 506
Query: 601 QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE 660
+ + EV+ + +Q + + +L+R +Q ++ ++ ER++M A + L+ + E
Sbjct: 507 EVASRDQEVEHVRQQYQR---DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEE 563
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS 720
EE Q ++++ +LR +EL Q++ME+E+ + E L +++ + EL+ A+ S
Sbjct: 564 TSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE---LGEKIEVLQRELEQARAS 620
Query: 721 --EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
+ R+ L +ELL+ +++L++L ++ QE R R+REL L+ E + +E+
Sbjct: 621 AGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE-ADRGREL 679
Query: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
++ Q LQ LR+ EEA+K V + + Q +A E ++ QEEN++ + R
Sbjct: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
Query: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE 898
LE+++ + + ++ + EA+ ++ L++ E E +QLEEAL +++EE +A+RALE
Sbjct: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
Query: 899 NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
LE AQ L++ QEQ+ L+ L+EE +Q+E LRR K E+E ++ L +T+++L KE+
Sbjct: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859
Query: 959 DIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME 1018
I E S+ + +LQ QL++YKEK RRE+A+ QRQ K+ EAEK+ ++QDE++ +
Sbjct: 860 KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR 919
Query: 1019 EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELE 1078
+ L+ Q +D A ++LL Q L+ LE E E K +DDR+R +K +E+KVS+LE EL+
Sbjct: 920 QALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELD 979
Query: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEG 1138
EE+N +LL++R++R R+Q++QLR EL+QER+ARQDLECDKISLERQNKDLK+R+ EG
Sbjct: 980 EEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEG 1039
Query: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198
+ S + Q+E++ L++RL++EER++ LQ +NR+LERKVKEL +Q++DE +
Sbjct: 1040 FQKPSAS--LSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVN 1097
Query: 1199 DQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
DQKDQLSLR+KA+KRQV+EAEEEI+RL+ +KK QRE+EEQ ++NE LQ ++ S++KD
Sbjct: 1098 DQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKD-S 1156
Query: 1259 LKKLPSKVLDDMDDDDDLSTD 1279
+K + ++ LS+D
Sbjct: 1157 WRKASRSAAESALKNEGLSSD 1177
Score = 242 bits (617), Expect = 2e-63
Identities = 204/778 (26%), Positives = 386/778 (49%), Gaps = 86/778 (11%)
Query: 528 PSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQT 587
P+ ++TPDLL+ QQE + + K +Y L+EGS++++ + +RKV+LV EK+Q
Sbjct: 287 PTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQP 346
Query: 588 LKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM 647
L ++GS + + + +LT +V ELQR+L EVK +Q ++ + +
Sbjct: 347 LVMVSSGSTKA--------------VAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGL 392
Query: 648 RANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQL 707
LE EK EE S LQ+ LE +GE +++ +EL +K +Q + L+ Q+
Sbjct: 393 ERQLE-------EKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQV 445
Query: 708 SEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL 767
E+ ++L + E K L+++LL+ ++ L+++L K+ E+ LR RERELTALKGAL
Sbjct: 446 MELQNKLKHVQGPEP-AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGAL 504
Query: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
KEEV+S DQE++ +++QY + + LR S+++AT++ VL E ++ V+ L
Sbjct: 505 KEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL-------EAERQKMSALVRGL 557
Query: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL---VHAR 884
Q E L+ SEE + Q+ EDL+ K+ L + E ++EE L +
Sbjct: 558 QRE---LEETSEETGHWQSMFQKNKEDLRA----TKQELLQLRMEKEEMEEELGEKIEVL 610
Query: 885 KEEKEAVSARRALENELEAAQGNLSQTTQEQKQL-SEKLKEESEQKEQLRRLK------- 936
+ E E A ++E + L +T +E K+L +E+ +E + + R L+
Sbjct: 611 QRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLR 670
Query: 937 ------NEMENERWHLGKTIEKLQKEMADIVEASRTSTLE----------LQNQLDEYKE 980
E+E + L KT+++L+++ + +A + E ++ L E +E
Sbjct: 671 VEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQE 730
Query: 981 KN---RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL 1037
+N RR + +++QLKE + +++D+++ +E E + + A + + +
Sbjct: 731 ENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790
Query: 1038 LEQTLKDLEYELE----AKSHLKDDRSRLVKQMEDKVSQLEM------ELEEERNNSDLL 1087
L + LE LE + L ++ L + +E++ Q E+ ELEE++ D
Sbjct: 791 LAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRT 850
Query: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
+R+++ E++ + + LQ+ A+ LE K R+ D + + + GL
Sbjct: 851 VDRLNKELEKIGEDSKQALQQLQAQ--LEDYKEKARREVADAQRQAKDWASEAEKTSGGL 908
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLR 1207
+++ I L L++ + +R +L L ++++ L + +++ S D+ Q
Sbjct: 909 -SRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQ---- 963
Query: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQL---NSMKKDLRLKKL 1262
LK ++ +V E E+D +++ + L + D + L+ +L S ++DL K+
Sbjct: 964 LKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKI 1021
Score = 52.4 bits (124), Expect = 3e-06
Identities = 30/81 (37%), Positives = 49/81 (60%), Gaps = 14/81 (17%)
Query: 30 RSSQNSKAGSYGVSIRVQGIDGHPYIVLNNTERCLAGTSFSENGPPFPPPVINNLPLHSS 89
R +++++A +YGV++RVQGI G P++VLN+ E+ G SF I +
Sbjct: 41 RPAKDARASTYGVAVRVQGIAGQPFVVLNSGEK--GGDSFGVQ--------IKGANDQGA 90
Query: 90 NGSVPKENSEELQLPENPYAQ 110
+G++ S +L+LPENPY+Q
Sbjct: 91 SGAL----SSDLELPENPYSQ 107
Score = 50.4 bits (119), Expect = 1e-05
Identities = 60/258 (23%), Positives = 121/258 (46%), Gaps = 36/258 (13%)
Query: 540 LKGQQELTQQTNEETAKQILYNYLKEGSTDND-DATKRKVNLVFEKIQTLKSRAAGSAQG 598
L+ + E +++ ++ A+Q+ K + + D K V L+ +++ +G
Sbjct: 946 LEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVN----------RG 995
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
+Q +E+ + L + L+RQ + ++K + E ++ A+L +L SQ
Sbjct: 996 RDQVDQLRTELMQERSARQDLECDKISLERQNK-DLKTRLASSEGFQKPSASLSQLESQ- 1053
Query: 659 NEKVEENSTLQQR----LEESEGELRKNLEEL-FQVKMERE-------QHQTEIRDLQDQ 706
N+ ++E ++R L+ + +L + ++EL Q++ ER+ Q ++ L+ Q
Sbjct: 1054 NQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQ 1113
Query: 707 LSEMHDE---LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTAL 763
+ E +E LD ++ RE +EE + + LQ + K ++D RK R +A
Sbjct: 1114 VDEAEEEIERLDGLRKKAQRE----VEEQHEVNEQLQARI--KSLEKDSWRKASR--SAA 1165
Query: 764 KGALKEEVSSHDQEMDKL 781
+ ALK E S D+E D +
Sbjct: 1166 ESALKNEGLSSDEEFDSV 1183
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 264 bits (675), Expect = 4e-70
Identities = 218/826 (26%), Positives = 424/826 (51%), Gaps = 104/826 (12%)
Query: 507 QNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEG 566
+N+A D G + ++KT + T D QQEL + +E +L L E
Sbjct: 1134 RNKAEKQKRDLGEELEALKT-----ELEDTLDSTATQQELRAKREQEVT--VLKKALDEE 1186
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ-KSKLTIEVAE 625
+ ++ ++Q ++ + A + + + K L++ K L E A+
Sbjct: 1187 TRSHE-----------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 626 LQRQLQLEVKNQQNIKEERERMRANLEEL----------RSQHNEKVE----ENSTLQQR 671
L +L++ + +Q ++ +++++ A ++EL R++ N+KV E ++
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 672 LEESEGELRK-------------NLEELFQVKMEREQH-QTEIRDLQDQLSEMHDELDS- 716
L E+EG+ K + +EL Q + ++ + T++R L+++ + + D+LD
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 717 --AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
AK++ +R L +L +K+ LQD E E+ ++ ++E+ L +E+ +++
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 775 D----------QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTS-----EQDQAG 819
D QE+D L D + Q + ++ K ++LA N S E+D+A
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 820 TEMRVK------LLQEENEKLQGRSEELERRVAQLQRQIEDL---KGDEAKAKETLKK-- 868
E R K L + E L+ + EELER L+ ++EDL K D K L+K
Sbjct: 1476 AEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 869 --YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
E ++ +++ L E + A+ LE ++A +G + Q + + +E+ + +
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 927 EQKEQLRRLKNEMENERWHLGKTI---EKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983
++ QL + E+E+ER +KL+ ++ D+ E S ++ + + + K +
Sbjct: 1595 QR--QLHEYETELEDERKQRALAAAAKKKLEGDLKDL-ELQADSAIKGREEAIKQLRKLQ 1651
Query: 984 RELAEMQRQLKEKTLE-------AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEA-LTKR 1035
++ + QR+L++ A+++ A ++ ++ ++E+L +RA+ +A L K
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
+L E+ L L ++ L+D++ RL E +++QLE ELEEE+ N + +S+R+ ++
Sbjct: 1712 ELAEE----LASSLSGRNALQDEKRRL----EARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARI 1155
+Q EQL NEL ER+ Q E + LERQNK+L+S++ +EG+ +S + + +EA+I
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 1156 AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL---SLRLKAMK 1212
A+LE+++E E R++ S ++ ++K+KE+++QV+DE K+Q + R+K +K
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 1213 RQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
RQ+EEAEEE R+ ++++KLQREL+E + NE + ++N++K LR
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 208 bits (529), Expect = 3e-53
Identities = 175/765 (22%), Positives = 367/765 (47%), Gaps = 68/765 (8%)
Query: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACN 604
+L + T E K++ L +N + +RK L+ E+I L + A +
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK--LLEERISDLTTNLAEEEE------- 1020
Query: 605 STSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEE 664
+ K+L + K+K ++EL+ +L+ E K++Q +++ + ++ + + Q + +
Sbjct: 1021 ---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDS---AKRSE 721
+ L+ +L + E EL+ L L ++ +IR+L+ +S++ ++LDS A+
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
+++K L EEL K +L+D L + Q++L KRE+E+T LK AL EE SH+ ++ ++
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 782 KEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEEL 841
++++ ++ L E +E+ + L T E++ A +++L + ++++ + ++L
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 842 ERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901
E +V +LQ + D + A+ + + K + E+ + L A + + +L ++L
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 902 EAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIV 961
+ Q L + T+++ +S KL++ E++ L+ +E + +L + I L +++D
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 962 EASR--TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEM----- 1014
+ + ST+E L+E K++ ++E+ + +Q +EK +K T ++Q E+
Sbjct: 1378 KKLQDFASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 1015 --------------------RLMEEELR-------DYQRAQDEALTKRQLLEQTLKDLEY 1047
+L+ EE + RA+ EA K + LE
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLE---MELEEERNNSDLLSERISRSREQMEQLRNE 1104
LEAK L+ L +MED VS + + E + L ++ + Q+E+L +E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 1105 LLQERAARQDLECDKISLERQ-NKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLE 1163
L A+ LE + +L+ Q +DL++R E R Q++ ++ E E LE
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--------QLQRQLHEYETELE 1606
Query: 1164 SEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID 1223
E + RA + ++LE +K+L +Q D S +++ +L+ ++ Q+++ + E++
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQAD----SAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLD 1268
+S+ ++ +E + L+ L +++DL + K D
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Score = 159 bits (401), Expect = 2e-38
Identities = 155/681 (22%), Positives = 318/681 (46%), Gaps = 73/681 (10%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
K K ++V + ++Q + Q KE +++ L+EL +H++ EE + LQ++L ++
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL-QA 898
Query: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE-ELLQ 734
E EL EE+ R + + ++L++ L EM A+ E+ ++G ++ E +
Sbjct: 899 ETELYAEAEEM------RVRLAAKKQELEEILHEM-----EARLEEEEDRGQQLQAERKK 947
Query: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQA 791
Q + DL EE+E +K + E + +K +E+ D + +KL + E +
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK----ERKL 1003
Query: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN-EKLQGRSEELERRVAQLQR 850
L E + + T N+ E+++A ++K E +L+ R ++ E+ +L++
Sbjct: 1004 LEERISDLTTNL--------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 851 QIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910
L+GD + E + + +I +L+ L K+E+E +A L++E+ AQ N
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEI--AQKN--N 1108
Query: 911 TTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLE 970
++ ++L + + E + R +N+ E ++ LG+ +E L+ E+ D ++++ T
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ--- 1165
Query: 971 LQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME--EELRDYQRAQ 1028
E + K +E+ +++ L E+T + ++++ M+ + + E E+L ++RA+
Sbjct: 1166 -----QELRAKREQEVTVLKKALDEET-RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLS 1088
+Q LE+ DL EL K + K++E +V +L+ + + L+
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLV 1148
+++ + + ++E + L + L D SL Q +D + ++ E + + +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLNVSTKL 1338
Query: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD--------- 1199
Q+E L+D+L+ E + N LER + L +Q+ D L D
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQN-------LERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 1200 -QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE-QMDMNEHLQGQLNSMKKDL 1257
K + ++ + +Q EE D+LE +K +LQ+EL++ +D++ Q N KK
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 1258 RL-------KKLPSKVLDDMD 1271
+ K + SK D+ D
Sbjct: 1452 KFDQLLAEEKNISSKYADERD 1472
Score = 155 bits (393), Expect = 2e-37
Identities = 168/744 (22%), Positives = 338/744 (45%), Gaps = 104/744 (13%)
Query: 607 SEVKDLLEQKSKLTIEVAELQRQLQLEVK--------------NQQNIKEERERMRANLE 652
+E+K+L ++ S+LT E LQ QLQ E + +Q ++E M A LE
Sbjct: 873 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932
Query: 653 ELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD 712
E + + E + Q++ + E +L + ++++E+ + +I+ L+D++ M D
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 713 ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ----EDLLRKRERELTALKGALK 768
+ + K S++R+ L+EE + DL L +EE+ L K E ++ L+ LK
Sbjct: 993 Q--NNKLSKERK---LLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 769 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV-EVLASRSNTSEQDQAGTEMRVKLL 827
+E S QE++KLK + + + E + + + E+ + E+ QA +
Sbjct: 1045 KEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA---- 883
++N L+ + ELE ++ LQ ++ + KA++ + E+ L+ L
Sbjct: 1104 AQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 884 -------RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ----KEQL 932
K E+E ++AL+ E + + + + Q+ Q E+L E+ EQ K L
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222
Query: 933 RRLKNEMENERWHLG---KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE- 988
+ K +E E L + + + ++E+ + ELQ++ + E+ R EL +
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD-GERARAELNDK 1281
Query: 989 ---MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDE-------ALTKRQLL 1038
+Q +++ T ++ A+K+ ++ + +L+D Q E TK + L
Sbjct: 1282 VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 1039 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
E+ L+ +L+ + K + R + + ++S + +L++ + + L E R ++++
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 1099 EQLRNELLQERAARQDLECDKISLERQNKDL-------KSRIIHLEGSYRSSKEGLVVQ- 1150
E L + ++ AA LE K L+++ DL + + +LE R + L +
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 1151 -MEARIAELEDRLESEERD------------------RANLQLSNRRLERKVKELVMQVD 1191
+ ++ A+ DR E+E R+ + L+ +N+ L+ ++++LV D
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Query: 1192 DEHLS---LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL-----------QRELE 1237
D + L K L +++ MK Q+EE E+E+ E +K +L +R+L+
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 1238 EQMDMNE----HLQGQLNSMKKDL 1257
+ + NE LQ QL+ + +L
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETEL 1605
Score = 148 bits (374), Expect = 3e-35
Identities = 137/574 (23%), Positives = 279/574 (48%), Gaps = 38/574 (6%)
Query: 730 EELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAEL 789
EE +QAK+D +L KE Q+ K E EL L+ ++ S +E + L+EQ AE
Sbjct: 851 EEEMQAKED--ELQKTKERQQ----KAENELKELE----QKHSQLTEEKNLLQEQLQAET 900
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQ 849
+ E+ E + LA++ E+ E R++ ++ ++LQ +++ +++ L+
Sbjct: 901 ELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 850 RQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLS 909
Q+E+ + K + E +I++LE+ ++ + + R+ LE + NL+
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 910 QTTQEQKQLSE-KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA---SR 965
+ ++ K L++ K K ES E RLK E E R L K KL+ + +D E +
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQ 1075
Query: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
EL+ QL + +E+ + LA + ++ +K +K R +++ + ++E+L +
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQEDLDSER 1131
Query: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE-RNNS 1084
A+++A +++ L + L+ L+ ELE + L + E +V+ L+ L+EE R++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSK 1144
+ E + + +E+L +L Q + A+ +L+ +K +LE++N DL + + G +
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE-LRVLGQAKQEV 1250
Query: 1145 EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD----------EH 1194
E ++EA++ EL+ + ER RA L +L+ +V+ + +++ +
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 1195 LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
SL+ Q L+ RQ ++ +LE + LQ +L+E+M+ ++L+ ++++
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 1255 KDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPV 1288
L K K L D + +G ++ +
Sbjct: 1371 IQLSDSK---KKLQDFASTVEALEEGKKRFQKEI 1401
Score = 110 bits (274), Expect = 1e-23
Identities = 103/503 (20%), Positives = 231/503 (45%), Gaps = 34/503 (6%)
Query: 507 QNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEG 566
++RA A + + K +S+ +A + L+ ++EL E ++L +++
Sbjct: 1471 RDRAEAEAREKETKALSL--------ARALEEALEAKEEL------ERTNKMLKAEMEDL 1516
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAEL 626
+ DD K V E ++ ++ + Q E++ + K +L + + L
Sbjct: 1517 VSSKDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 627 QRQLQ--LEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLE 684
+ Q + L+ +++QN +E+R +++ L E ++ ++ ++ + ++ EG+L+
Sbjct: 1573 KGQFERDLQARDEQN-EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLI 744
+ RE+ ++R LQ Q+ + EL+ A+ S D E +AK DL+
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 745 AKEEQEDLLRKRER---ELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK 801
+E+ R R++ E L L +S + D+ K + +A + L E +EE
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE-KRRLEARIAQLEEELEEEQG 1750
Query: 802 NVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD-EA 860
N+E ++ R + Q + + +K + ++LER+ +L+ ++ +++G ++
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 861 KAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE 920
K K T+ E +I QLEE + +E++ A + + + +L+ + +++++++E
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK----EILLQVEDERKMAE 1866
Query: 921 KLKEESE----QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976
+ KE++E + +QL+R E E E + KLQ+E+ + E++ E+
Sbjct: 1867 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 977 EYKEKNRRELAEMQRQLKEKTLE 999
+ + N +R + +E
Sbjct: 1927 KLRRGNETSFVPSRRSGGRRVIE 1949
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 264 bits (675), Expect = 4e-70
Identities = 218/826 (26%), Positives = 424/826 (51%), Gaps = 104/826 (12%)
Query: 507 QNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEG 566
+N+A D G + ++KT + T D QQEL + +E +L L E
Sbjct: 1141 RNKAEKQKRDLGEELEALKT-----ELEDTLDSTATQQELRAKREQEVT--VLKKALDEE 1193
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ-KSKLTIEVAE 625
+ ++ ++Q ++ + A + + + K L++ K L E A+
Sbjct: 1194 TRSHE-----------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 626 LQRQLQLEVKNQQNIKEERERMRANLEEL----------RSQHNEKVE----ENSTLQQR 671
L +L++ + +Q ++ +++++ A ++EL R++ N+KV E ++
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 672 LEESEGELRK-------------NLEELFQVKMEREQH-QTEIRDLQDQLSEMHDELDS- 716
L E+EG+ K + +EL Q + ++ + T++R L+++ + + D+LD
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 717 --AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
AK++ +R L +L +K+ LQD E E+ ++ ++E+ L +E+ +++
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 775 D----------QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTS-----EQDQAG 819
D QE+D L D + Q + ++ K ++LA N S E+D+A
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 820 TEMRVK------LLQEENEKLQGRSEELERRVAQLQRQIEDL---KGDEAKAKETLKK-- 868
E R K L + E L+ + EELER L+ ++EDL K D K L+K
Sbjct: 1483 AEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 869 --YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
E ++ +++ L E + A+ LE ++A +G + Q + + +E+ + +
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 927 EQKEQLRRLKNEMENERWHLGKTI---EKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983
++ QL + E+E+ER +KL+ ++ D+ E S ++ + + + K +
Sbjct: 1602 QR--QLHEYETELEDERKQRALAAAAKKKLEGDLKDL-ELQADSAIKGREEAIKQLRKLQ 1658
Query: 984 RELAEMQRQLKEKTLE-------AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEA-LTKR 1035
++ + QR+L++ A+++ A ++ ++ ++E+L +RA+ +A L K
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
+L E+ L L ++ L+D++ RL E +++QLE ELEEE+ N + +S+R+ ++
Sbjct: 1719 ELAEE----LASSLSGRNALQDEKRRL----EARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARI 1155
+Q EQL NEL ER+ Q E + LERQNK+L+S++ +EG+ +S + + +EA+I
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 1156 AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL---SLRLKAMK 1212
A+LE+++E E R++ S ++ ++K+KE+++QV+DE K+Q + R+K +K
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 1213 RQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
RQ+EEAEEE R+ ++++KLQREL+E + NE + ++N++K LR
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 208 bits (529), Expect = 3e-53
Identities = 175/765 (22%), Positives = 367/765 (47%), Gaps = 68/765 (8%)
Query: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACN 604
+L + T E K++ L +N + +RK L+ E+I L + A +
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK--LLEERISDLTTNLAEEEE------- 1027
Query: 605 STSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEE 664
+ K+L + K+K ++EL+ +L+ E K++Q +++ + ++ + + Q + +
Sbjct: 1028 ---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDS---AKRSE 721
+ L+ +L + E EL+ L L ++ +IR+L+ +S++ ++LDS A+
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
+++K L EEL K +L+D L + Q++L KRE+E+T LK AL EE SH+ ++ ++
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 782 KEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEEL 841
++++ ++ L E +E+ + L T E++ A +++L + ++++ + ++L
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 842 ERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901
E +V +LQ + D + A+ + + K + E+ + L A + + +L ++L
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 902 EAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIV 961
+ Q L + T+++ +S KL++ E++ L+ +E + +L + I L +++D
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 962 EASR--TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEM----- 1014
+ + ST+E L+E K++ ++E+ + +Q +EK +K T ++Q E+
Sbjct: 1385 KKLQDFASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 1015 --------------------RLMEEELR-------DYQRAQDEALTKRQLLEQTLKDLEY 1047
+L+ EE + RA+ EA K + LE
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLE---MELEEERNNSDLLSERISRSREQMEQLRNE 1104
LEAK L+ L +MED VS + + E + L ++ + Q+E+L +E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 1105 LLQERAARQDLECDKISLERQ-NKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLE 1163
L A+ LE + +L+ Q +DL++R E R Q++ ++ E E LE
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--------QLQRQLHEYETELE 1613
Query: 1164 SEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID 1223
E + RA + ++LE +K+L +Q D S +++ +L+ ++ Q+++ + E++
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQAD----SAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLD 1268
+S+ ++ +E + L+ L +++DL + K D
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Score = 159 bits (401), Expect = 2e-38
Identities = 155/681 (22%), Positives = 318/681 (46%), Gaps = 73/681 (10%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
K K ++V + ++Q + Q KE +++ L+EL +H++ EE + LQ++L ++
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL-QA 905
Query: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE-ELLQ 734
E EL EE+ R + + ++L++ L EM A+ E+ ++G ++ E +
Sbjct: 906 ETELYAEAEEM------RVRLAAKKQELEEILHEM-----EARLEEEEDRGQQLQAERKK 954
Query: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQA 791
Q + DL EE+E +K + E + +K +E+ D + +KL + E +
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK----ERKL 1010
Query: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN-EKLQGRSEELERRVAQLQR 850
L E + + T N+ E+++A ++K E +L+ R ++ E+ +L++
Sbjct: 1011 LEERISDLTTNL--------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 851 QIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910
L+GD + E + + +I +L+ L K+E+E +A L++E+ AQ N
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEI--AQKN--N 1115
Query: 911 TTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLE 970
++ ++L + + E + R +N+ E ++ LG+ +E L+ E+ D ++++ T
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ--- 1172
Query: 971 LQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME--EELRDYQRAQ 1028
E + K +E+ +++ L E+T + ++++ M+ + + E E+L ++RA+
Sbjct: 1173 -----QELRAKREQEVTVLKKALDEET-RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLS 1088
+Q LE+ DL EL K + K++E +V +L+ + + L+
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLV 1148
+++ + + ++E + L + L D SL Q +D + ++ E + + +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLNVSTKL 1345
Query: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD--------- 1199
Q+E L+D+L+ E + N LER + L +Q+ D L D
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQN-------LERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 1200 -QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE-QMDMNEHLQGQLNSMKKDL 1257
K + ++ + +Q EE D+LE +K +LQ+EL++ +D++ Q N KK
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 1258 RL-------KKLPSKVLDDMD 1271
+ K + SK D+ D
Sbjct: 1459 KFDQLLAEEKNISSKYADERD 1479
Score = 155 bits (393), Expect = 2e-37
Identities = 168/744 (22%), Positives = 338/744 (45%), Gaps = 104/744 (13%)
Query: 607 SEVKDLLEQKSKLTIEVAELQRQLQLEVK--------------NQQNIKEERERMRANLE 652
+E+K+L ++ S+LT E LQ QLQ E + +Q ++E M A LE
Sbjct: 880 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939
Query: 653 ELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD 712
E + + E + Q++ + E +L + ++++E+ + +I+ L+D++ M D
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 713 ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ----EDLLRKRERELTALKGALK 768
+ + K S++R+ L+EE + DL L +EE+ L K E ++ L+ LK
Sbjct: 1000 Q--NNKLSKERK---LLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 769 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV-EVLASRSNTSEQDQAGTEMRVKLL 827
+E S QE++KLK + + + E + + + E+ + E+ QA +
Sbjct: 1052 KEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA---- 883
++N L+ + ELE ++ LQ ++ + KA++ + E+ L+ L
Sbjct: 1111 AQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 884 -------RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ----KEQL 932
K E+E ++AL+ E + + + + Q+ Q E+L E+ EQ K L
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229
Query: 933 RRLKNEMENERWHLG---KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE- 988
+ K +E E L + + + ++E+ + ELQ++ + E+ R EL +
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD-GERARAELNDK 1288
Query: 989 ---MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDE-------ALTKRQLL 1038
+Q +++ T ++ A+K+ ++ + +L+D Q E TK + L
Sbjct: 1289 VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 1039 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
E+ L+ +L+ + K + R + + ++S + +L++ + + L E R ++++
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 1099 EQLRNELLQERAARQDLECDKISLERQNKDL-------KSRIIHLEGSYRSSKEGLVVQ- 1150
E L + ++ AA LE K L+++ DL + + +LE R + L +
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 1151 -MEARIAELEDRLESEERD------------------RANLQLSNRRLERKVKELVMQVD 1191
+ ++ A+ DR E+E R+ + L+ +N+ L+ ++++LV D
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Query: 1192 DEHLS---LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL-----------QRELE 1237
D + L K L +++ MK Q+EE E+E+ E +K +L +R+L+
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 1238 EQMDMNE----HLQGQLNSMKKDL 1257
+ + NE LQ QL+ + +L
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETEL 1612
Score = 148 bits (374), Expect = 3e-35
Identities = 137/574 (23%), Positives = 279/574 (48%), Gaps = 38/574 (6%)
Query: 730 EELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAEL 789
EE +QAK+D +L KE Q+ K E EL L+ ++ S +E + L+EQ AE
Sbjct: 858 EEEMQAKED--ELQKTKERQQ----KAENELKELE----QKHSQLTEEKNLLQEQLQAET 907
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQ 849
+ E+ E + LA++ E+ E R++ ++ ++LQ +++ +++ L+
Sbjct: 908 ELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 850 RQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLS 909
Q+E+ + K + E +I++LE+ ++ + + R+ LE + NL+
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 910 QTTQEQKQLSE-KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA---SR 965
+ ++ K L++ K K ES E RLK E E R L K KL+ + +D E +
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQ 1082
Query: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
EL+ QL + +E+ + LA + ++ +K +K R +++ + ++E+L +
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQEDLDSER 1138
Query: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE-RNNS 1084
A+++A +++ L + L+ L+ ELE + L + E +V+ L+ L+EE R++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSK 1144
+ E + + +E+L +L Q + A+ +L+ +K +LE++N DL + + G +
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE-LRVLGQAKQEV 1257
Query: 1145 EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD----------EH 1194
E ++EA++ EL+ + ER RA L +L+ +V+ + +++ +
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 1195 LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
SL+ Q L+ RQ ++ +LE + LQ +L+E+M+ ++L+ ++++
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 1255 KDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPV 1288
L K K L D + +G ++ +
Sbjct: 1378 IQLSDSK---KKLQDFASTVEALEEGKKRFQKEI 1408
Score = 110 bits (274), Expect = 1e-23
Identities = 103/503 (20%), Positives = 231/503 (45%), Gaps = 34/503 (6%)
Query: 507 QNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEG 566
++RA A + + K +S+ +A + L+ ++EL E ++L +++
Sbjct: 1478 RDRAEAEAREKETKALSL--------ARALEEALEAKEEL------ERTNKMLKAEMEDL 1523
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAEL 626
+ DD K V E ++ ++ + Q E++ + K +L + + L
Sbjct: 1524 VSSKDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Query: 627 QRQLQ--LEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLE 684
+ Q + L+ +++QN +E+R +++ L E ++ ++ ++ + ++ EG+L+
Sbjct: 1580 KGQFERDLQARDEQN-EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLI 744
+ RE+ ++R LQ Q+ + EL+ A+ S D E +AK DL+
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 745 AKEEQEDLLRKRER---ELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK 801
+E+ R R++ E L L +S + D+ K + +A + L E +EE
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE-KRRLEARIAQLEEELEEEQG 1757
Query: 802 NVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD-EA 860
N+E ++ R + Q + + +K + ++LER+ +L+ ++ +++G ++
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 861 KAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE 920
K K T+ E +I QLEE + +E++ A + + + +L+ + +++++++E
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK----EILLQVEDERKMAE 1873
Query: 921 KLKEESE----QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976
+ KE++E + +QL+R E E E + KLQ+E+ + E++ E+
Sbjct: 1874 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 977 EYKEKNRRELAEMQRQLKEKTLE 999
+ + N +R + +E
Sbjct: 1934 KLRRGNETSFVPSRRSGGRRVIE 1956
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 264 bits (675), Expect = 4e-70
Identities = 218/826 (26%), Positives = 424/826 (51%), Gaps = 104/826 (12%)
Query: 507 QNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEG 566
+N+A D G + ++KT + T D QQEL + +E +L L E
Sbjct: 1141 RNKAEKQKRDLGEELEALKT-----ELEDTLDSTATQQELRAKREQEVT--VLKKALDEE 1193
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ-KSKLTIEVAE 625
+ ++ ++Q ++ + A + + + K L++ K L E A+
Sbjct: 1194 TRSHE-----------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 626 LQRQLQLEVKNQQNIKEERERMRANLEEL----------RSQHNEKVE----ENSTLQQR 671
L +L++ + +Q ++ +++++ A ++EL R++ N+KV E ++
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 672 LEESEGELRK-------------NLEELFQVKMEREQH-QTEIRDLQDQLSEMHDELDS- 716
L E+EG+ K + +EL Q + ++ + T++R L+++ + + D+LD
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 717 --AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
AK++ +R L +L +K+ LQD E E+ ++ ++E+ L +E+ +++
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 775 D----------QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTS-----EQDQAG 819
D QE+D L D + Q + ++ K ++LA N S E+D+A
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 820 TEMRVK------LLQEENEKLQGRSEELERRVAQLQRQIEDL---KGDEAKAKETLKK-- 868
E R K L + E L+ + EELER L+ ++EDL K D K L+K
Sbjct: 1483 AEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 869 --YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
E ++ +++ L E + A+ LE ++A +G + Q + + +E+ + +
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 927 EQKEQLRRLKNEMENERWHLGKTI---EKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983
++ QL + E+E+ER +KL+ ++ D+ E S ++ + + + K +
Sbjct: 1602 QR--QLHEYETELEDERKQRALAAAAKKKLEGDLKDL-ELQADSAIKGREEAIKQLRKLQ 1658
Query: 984 RELAEMQRQLKEKTLE-------AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEA-LTKR 1035
++ + QR+L++ A+++ A ++ ++ ++E+L +RA+ +A L K
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
+L E+ L L ++ L+D++ RL E +++QLE ELEEE+ N + +S+R+ ++
Sbjct: 1719 ELAEE----LASSLSGRNALQDEKRRL----EARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARI 1155
+Q EQL NEL ER+ Q E + LERQNK+L+S++ +EG+ +S + + +EA+I
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 1156 AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL---SLRLKAMK 1212
A+LE+++E E R++ S ++ ++K+KE+++QV+DE K+Q + R+K +K
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 1213 RQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
RQ+EEAEEE R+ ++++KLQREL+E + NE + ++N++K LR
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 208 bits (529), Expect = 3e-53
Identities = 175/765 (22%), Positives = 367/765 (47%), Gaps = 68/765 (8%)
Query: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACN 604
+L + T E K++ L +N + +RK L+ E+I L + A +
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK--LLEERISDLTTNLAEEEE------- 1027
Query: 605 STSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEE 664
+ K+L + K+K ++EL+ +L+ E K++Q +++ + ++ + + Q + +
Sbjct: 1028 ---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDS---AKRSE 721
+ L+ +L + E EL+ L L ++ +IR+L+ +S++ ++LDS A+
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
+++K L EEL K +L+D L + Q++L KRE+E+T LK AL EE SH+ ++ ++
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 782 KEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEEL 841
++++ ++ L E +E+ + L T E++ A +++L + ++++ + ++L
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 842 ERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901
E +V +LQ + D + A+ + + K + E+ + L A + + +L ++L
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 902 EAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIV 961
+ Q L + T+++ +S KL++ E++ L+ +E + +L + I L +++D
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 962 EASR--TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEM----- 1014
+ + ST+E L+E K++ ++E+ + +Q +EK +K T ++Q E+
Sbjct: 1385 KKLQDFASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 1015 --------------------RLMEEELR-------DYQRAQDEALTKRQLLEQTLKDLEY 1047
+L+ EE + RA+ EA K + LE
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLE---MELEEERNNSDLLSERISRSREQMEQLRNE 1104
LEAK L+ L +MED VS + + E + L ++ + Q+E+L +E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 1105 LLQERAARQDLECDKISLERQ-NKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLE 1163
L A+ LE + +L+ Q +DL++R E R Q++ ++ E E LE
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--------QLQRQLHEYETELE 1613
Query: 1164 SEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID 1223
E + RA + ++LE +K+L +Q D S +++ +L+ ++ Q+++ + E++
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQAD----SAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLD 1268
+S+ ++ +E + L+ L +++DL + K D
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Score = 159 bits (401), Expect = 2e-38
Identities = 155/681 (22%), Positives = 318/681 (46%), Gaps = 73/681 (10%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
K K ++V + ++Q + Q KE +++ L+EL +H++ EE + LQ++L ++
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL-QA 905
Query: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE-ELLQ 734
E EL EE+ R + + ++L++ L EM A+ E+ ++G ++ E +
Sbjct: 906 ETELYAEAEEM------RVRLAAKKQELEEILHEM-----EARLEEEEDRGQQLQAERKK 954
Query: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQA 791
Q + DL EE+E +K + E + +K +E+ D + +KL + E +
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK----ERKL 1010
Query: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN-EKLQGRSEELERRVAQLQR 850
L E + + T N+ E+++A ++K E +L+ R ++ E+ +L++
Sbjct: 1011 LEERISDLTTNL--------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 851 QIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910
L+GD + E + + +I +L+ L K+E+E +A L++E+ AQ N
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEI--AQKN--N 1115
Query: 911 TTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLE 970
++ ++L + + E + R +N+ E ++ LG+ +E L+ E+ D ++++ T
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ--- 1172
Query: 971 LQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME--EELRDYQRAQ 1028
E + K +E+ +++ L E+T + ++++ M+ + + E E+L ++RA+
Sbjct: 1173 -----QELRAKREQEVTVLKKALDEET-RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLS 1088
+Q LE+ DL EL K + K++E +V +L+ + + L+
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLV 1148
+++ + + ++E + L + L D SL Q +D + ++ E + + +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLNVSTKL 1345
Query: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD--------- 1199
Q+E L+D+L+ E + N LER + L +Q+ D L D
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQN-------LERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 1200 -QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE-QMDMNEHLQGQLNSMKKDL 1257
K + ++ + +Q EE D+LE +K +LQ+EL++ +D++ Q N KK
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 1258 RL-------KKLPSKVLDDMD 1271
+ K + SK D+ D
Sbjct: 1459 KFDQLLAEEKNISSKYADERD 1479
Score = 155 bits (393), Expect = 2e-37
Identities = 168/744 (22%), Positives = 338/744 (45%), Gaps = 104/744 (13%)
Query: 607 SEVKDLLEQKSKLTIEVAELQRQLQLEVK--------------NQQNIKEERERMRANLE 652
+E+K+L ++ S+LT E LQ QLQ E + +Q ++E M A LE
Sbjct: 880 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939
Query: 653 ELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD 712
E + + E + Q++ + E +L + ++++E+ + +I+ L+D++ M D
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 713 ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ----EDLLRKRERELTALKGALK 768
+ + K S++R+ L+EE + DL L +EE+ L K E ++ L+ LK
Sbjct: 1000 Q--NNKLSKERK---LLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 769 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV-EVLASRSNTSEQDQAGTEMRVKLL 827
+E S QE++KLK + + + E + + + E+ + E+ QA +
Sbjct: 1052 KEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA---- 883
++N L+ + ELE ++ LQ ++ + KA++ + E+ L+ L
Sbjct: 1111 AQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 884 -------RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ----KEQL 932
K E+E ++AL+ E + + + + Q+ Q E+L E+ EQ K L
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229
Query: 933 RRLKNEMENERWHLG---KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE- 988
+ K +E E L + + + ++E+ + ELQ++ + E+ R EL +
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD-GERARAELNDK 1288
Query: 989 ---MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDE-------ALTKRQLL 1038
+Q +++ T ++ A+K+ ++ + +L+D Q E TK + L
Sbjct: 1289 VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 1039 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
E+ L+ +L+ + K + R + + ++S + +L++ + + L E R ++++
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 1099 EQLRNELLQERAARQDLECDKISLERQNKDL-------KSRIIHLEGSYRSSKEGLVVQ- 1150
E L + ++ AA LE K L+++ DL + + +LE R + L +
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 1151 -MEARIAELEDRLESEERD------------------RANLQLSNRRLERKVKELVMQVD 1191
+ ++ A+ DR E+E R+ + L+ +N+ L+ ++++LV D
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Query: 1192 DEHLS---LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL-----------QRELE 1237
D + L K L +++ MK Q+EE E+E+ E +K +L +R+L+
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 1238 EQMDMNE----HLQGQLNSMKKDL 1257
+ + NE LQ QL+ + +L
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETEL 1612
Score = 148 bits (374), Expect = 3e-35
Identities = 137/574 (23%), Positives = 279/574 (48%), Gaps = 38/574 (6%)
Query: 730 EELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAEL 789
EE +QAK+D +L KE Q+ K E EL L+ ++ S +E + L+EQ AE
Sbjct: 858 EEEMQAKED--ELQKTKERQQ----KAENELKELE----QKHSQLTEEKNLLQEQLQAET 907
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQ 849
+ E+ E + LA++ E+ E R++ ++ ++LQ +++ +++ L+
Sbjct: 908 ELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 850 RQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLS 909
Q+E+ + K + E +I++LE+ ++ + + R+ LE + NL+
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 910 QTTQEQKQLSE-KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA---SR 965
+ ++ K L++ K K ES E RLK E E R L K KL+ + +D E +
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQ 1082
Query: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
EL+ QL + +E+ + LA + ++ +K +K R +++ + ++E+L +
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQEDLDSER 1138
Query: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE-RNNS 1084
A+++A +++ L + L+ L+ ELE + L + E +V+ L+ L+EE R++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSK 1144
+ E + + +E+L +L Q + A+ +L+ +K +LE++N DL + + G +
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE-LRVLGQAKQEV 1257
Query: 1145 EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD----------EH 1194
E ++EA++ EL+ + ER RA L +L+ +V+ + +++ +
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 1195 LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
SL+ Q L+ RQ ++ +LE + LQ +L+E+M+ ++L+ ++++
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 1255 KDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPV 1288
L K K L D + +G ++ +
Sbjct: 1378 IQLSDSK---KKLQDFASTVEALEEGKKRFQKEI 1408
Score = 89.7 bits (221), Expect = 2e-17
Identities = 105/485 (21%), Positives = 215/485 (44%), Gaps = 82/485 (16%)
Query: 507 QNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEG 566
++RA A + + K +S+ +A + L+ ++EL E ++L +++
Sbjct: 1478 RDRAEAEAREKETKALSL--------ARALEEALEAKEEL------ERTNKMLKAEMEDL 1523
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAEL 626
+ DD K V E ++ ++ + Q E++ + K +L + + L
Sbjct: 1524 VSSKDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Query: 627 QRQLQ--LEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLE 684
+ Q + L+ +++QN +E+R +++ L E ++ ++ ++ + ++ EG+L+
Sbjct: 1580 KGQFERDLQARDEQN-EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDR--------EKGA--LIEELLQ 734
+ RE+ ++R LQ Q+ + EL+ A+ S D EK A L +L+Q
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 735 AKQDLQDLLIAKE----EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAE-- 788
++DL A++ E+E+L + L+ + AL++E + + +L+E+ + E
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSG-RNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 789 -LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE------- 840
++A+ + V +AT+ E L++ T E + L+ +N++L+ + E
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 841 --------LERRVAQLQRQIED-----------LKGDEAKAKETLKKYEGE--------- 872
LE ++AQL+ Q+E LK + K KE L + E E
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877
Query: 873 --------IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
++QL+ L A +E + + RR L+ EL+ A + +E L KL+
Sbjct: 1878 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937
Query: 925 ESEQK 929
Q+
Sbjct: 1938 PPPQE 1942
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 264 bits (675), Expect = 4e-70
Identities = 218/826 (26%), Positives = 424/826 (51%), Gaps = 104/826 (12%)
Query: 507 QNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEG 566
+N+A D G + ++KT + T D QQEL + +E +L L E
Sbjct: 1134 RNKAEKQKRDLGEELEALKT-----ELEDTLDSTATQQELRAKREQEVT--VLKKALDEE 1186
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ-KSKLTIEVAE 625
+ ++ ++Q ++ + A + + + K L++ K L E A+
Sbjct: 1187 TRSHE-----------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 626 LQRQLQLEVKNQQNIKEERERMRANLEEL----------RSQHNEKVE----ENSTLQQR 671
L +L++ + +Q ++ +++++ A ++EL R++ N+KV E ++
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 672 LEESEGELRK-------------NLEELFQVKMEREQH-QTEIRDLQDQLSEMHDELDS- 716
L E+EG+ K + +EL Q + ++ + T++R L+++ + + D+LD
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 717 --AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
AK++ +R L +L +K+ LQD E E+ ++ ++E+ L +E+ +++
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 775 D----------QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTS-----EQDQAG 819
D QE+D L D + Q + ++ K ++LA N S E+D+A
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 820 TEMRVK------LLQEENEKLQGRSEELERRVAQLQRQIEDL---KGDEAKAKETLKK-- 868
E R K L + E L+ + EELER L+ ++EDL K D K L+K
Sbjct: 1476 AEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 869 --YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
E ++ +++ L E + A+ LE ++A +G + Q + + +E+ + +
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 927 EQKEQLRRLKNEMENERWHLGKTI---EKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983
++ QL + E+E+ER +KL+ ++ D+ E S ++ + + + K +
Sbjct: 1595 QR--QLHEYETELEDERKQRALAAAAKKKLEGDLKDL-ELQADSAIKGREEAIKQLRKLQ 1651
Query: 984 RELAEMQRQLKEKTLE-------AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEA-LTKR 1035
++ + QR+L++ A+++ A ++ ++ ++E+L +RA+ +A L K
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
+L E+ L L ++ L+D++ RL E +++QLE ELEEE+ N + +S+R+ ++
Sbjct: 1712 ELAEE----LASSLSGRNALQDEKRRL----EARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARI 1155
+Q EQL NEL ER+ Q E + LERQNK+L+S++ +EG+ +S + + +EA+I
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 1156 AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL---SLRLKAMK 1212
A+LE+++E E R++ S ++ ++K+KE+++QV+DE K+Q + R+K +K
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 1213 RQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
RQ+EEAEEE R+ ++++KLQREL+E + NE + ++N++K LR
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 208 bits (529), Expect = 3e-53
Identities = 175/765 (22%), Positives = 367/765 (47%), Gaps = 68/765 (8%)
Query: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACN 604
+L + T E K++ L +N + +RK L+ E+I L + A +
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK--LLEERISDLTTNLAEEEE------- 1020
Query: 605 STSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEE 664
+ K+L + K+K ++EL+ +L+ E K++Q +++ + ++ + + Q + +
Sbjct: 1021 ---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDS---AKRSE 721
+ L+ +L + E EL+ L L ++ +IR+L+ +S++ ++LDS A+
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
+++K L EEL K +L+D L + Q++L KRE+E+T LK AL EE SH+ ++ ++
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 782 KEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEEL 841
++++ ++ L E +E+ + L T E++ A +++L + ++++ + ++L
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 842 ERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901
E +V +LQ + D + A+ + + K + E+ + L A + + +L ++L
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 902 EAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIV 961
+ Q L + T+++ +S KL++ E++ L+ +E + +L + I L +++D
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 962 EASR--TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEM----- 1014
+ + ST+E L+E K++ ++E+ + +Q +EK +K T ++Q E+
Sbjct: 1378 KKLQDFASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 1015 --------------------RLMEEELR-------DYQRAQDEALTKRQLLEQTLKDLEY 1047
+L+ EE + RA+ EA K + LE
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLE---MELEEERNNSDLLSERISRSREQMEQLRNE 1104
LEAK L+ L +MED VS + + E + L ++ + Q+E+L +E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 1105 LLQERAARQDLECDKISLERQ-NKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLE 1163
L A+ LE + +L+ Q +DL++R E R Q++ ++ E E LE
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--------QLQRQLHEYETELE 1606
Query: 1164 SEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID 1223
E + RA + ++LE +K+L +Q D S +++ +L+ ++ Q+++ + E++
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQAD----SAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLD 1268
+S+ ++ +E + L+ L +++DL + K D
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Score = 159 bits (401), Expect = 2e-38
Identities = 155/681 (22%), Positives = 318/681 (46%), Gaps = 73/681 (10%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
K K ++V + ++Q + Q KE +++ L+EL +H++ EE + LQ++L ++
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL-QA 898
Query: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE-ELLQ 734
E EL EE+ R + + ++L++ L EM A+ E+ ++G ++ E +
Sbjct: 899 ETELYAEAEEM------RVRLAAKKQELEEILHEM-----EARLEEEEDRGQQLQAERKK 947
Query: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQA 791
Q + DL EE+E +K + E + +K +E+ D + +KL + E +
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK----ERKL 1003
Query: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN-EKLQGRSEELERRVAQLQR 850
L E + + T N+ E+++A ++K E +L+ R ++ E+ +L++
Sbjct: 1004 LEERISDLTTNL--------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 851 QIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910
L+GD + E + + +I +L+ L K+E+E +A L++E+ AQ N
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLA---KKEEELQAALARLDDEI--AQKN--N 1108
Query: 911 TTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLE 970
++ ++L + + E + R +N+ E ++ LG+ +E L+ E+ D ++++ T
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ--- 1165
Query: 971 LQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME--EELRDYQRAQ 1028
E + K +E+ +++ L E+T + ++++ M+ + + E E+L ++RA+
Sbjct: 1166 -----QELRAKREQEVTVLKKALDEET-RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLS 1088
+Q LE+ DL EL K + K++E +V +L+ + + L+
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLV 1148
+++ + + ++E + L + L D SL Q +D + ++ E + + +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLNVSTKL 1338
Query: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD--------- 1199
Q+E L+D+L+ E + N LER + L +Q+ D L D
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQN-------LERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 1200 -QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE-QMDMNEHLQGQLNSMKKDL 1257
K + ++ + +Q EE D+LE +K +LQ+EL++ +D++ Q N KK
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 1258 RL-------KKLPSKVLDDMD 1271
+ K + SK D+ D
Sbjct: 1452 KFDQLLAEEKNISSKYADERD 1472
Score = 155 bits (393), Expect = 2e-37
Identities = 168/744 (22%), Positives = 338/744 (45%), Gaps = 104/744 (13%)
Query: 607 SEVKDLLEQKSKLTIEVAELQRQLQLEVK--------------NQQNIKEERERMRANLE 652
+E+K+L ++ S+LT E LQ QLQ E + +Q ++E M A LE
Sbjct: 873 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932
Query: 653 ELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD 712
E + + E + Q++ + E +L + ++++E+ + +I+ L+D++ M D
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 713 ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ----EDLLRKRERELTALKGALK 768
+ + K S++R+ L+EE + DL L +EE+ L K E ++ L+ LK
Sbjct: 993 Q--NNKLSKERK---LLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 769 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV-EVLASRSNTSEQDQAGTEMRVKLL 827
+E S QE++KLK + + + E + + + E+ + E+ QA +
Sbjct: 1045 KEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA---- 883
++N L+ + ELE ++ LQ ++ + KA++ + E+ L+ L
Sbjct: 1104 AQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 884 -------RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ----KEQL 932
K E+E ++AL+ E + + + + Q+ Q E+L E+ EQ K L
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222
Query: 933 RRLKNEMENERWHLG---KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE- 988
+ K +E E L + + + ++E+ + ELQ++ + E+ R EL +
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD-GERARAELNDK 1281
Query: 989 ---MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDE-------ALTKRQLL 1038
+Q +++ T ++ A+K+ ++ + +L+D Q E TK + L
Sbjct: 1282 VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 1039 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
E+ L+ +L+ + K + R + + ++S + +L++ + + L E R ++++
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 1099 EQLRNELLQERAARQDLECDKISLERQNKDL-------KSRIIHLEGSYRSSKEGLVVQ- 1150
E L + ++ AA LE K L+++ DL + + +LE R + L +
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 1151 -MEARIAELEDRLESEERD------------------RANLQLSNRRLERKVKELVMQVD 1191
+ ++ A+ DR E+E R+ + L+ +N+ L+ ++++LV D
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Query: 1192 DEHLS---LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL-----------QRELE 1237
D + L K L +++ MK Q+EE E+E+ E +K +L +R+L+
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 1238 EQMDMNE----HLQGQLNSMKKDL 1257
+ + NE LQ QL+ + +L
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETEL 1605
Score = 148 bits (374), Expect = 3e-35
Identities = 137/574 (23%), Positives = 279/574 (48%), Gaps = 38/574 (6%)
Query: 730 EELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAEL 789
EE +QAK+D +L KE Q+ K E EL L+ ++ S +E + L+EQ AE
Sbjct: 851 EEEMQAKED--ELQKTKERQQ----KAENELKELE----QKHSQLTEEKNLLQEQLQAET 900
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQ 849
+ E+ E + LA++ E+ E R++ ++ ++LQ +++ +++ L+
Sbjct: 901 ELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 850 RQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLS 909
Q+E+ + K + E +I++LE+ ++ + + R+ LE + NL+
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 910 QTTQEQKQLSE-KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA---SR 965
+ ++ K L++ K K ES E RLK E E R L K KL+ + +D E +
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQ 1075
Query: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
EL+ QL + +E+ + LA + ++ +K +K R +++ + ++E+L +
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQEDLDSER 1131
Query: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE-RNNS 1084
A+++A +++ L + L+ L+ ELE + L + E +V+ L+ L+EE R++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSK 1144
+ E + + +E+L +L Q + A+ +L+ +K +LE++N DL + + G +
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE-LRVLGQAKQEV 1250
Query: 1145 EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD----------EH 1194
E ++EA++ EL+ + ER RA L +L+ +V+ + +++ +
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 1195 LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
SL+ Q L+ RQ ++ +LE + LQ +L+E+M+ ++L+ ++++
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 1255 KDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPV 1288
L K K L D + +G ++ +
Sbjct: 1371 IQLSDSK---KKLQDFASTVEALEEGKKRFQKEI 1401
Score = 89.7 bits (221), Expect = 2e-17
Identities = 105/485 (21%), Positives = 215/485 (44%), Gaps = 82/485 (16%)
Query: 507 QNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEG 566
++RA A + + K +S+ +A + L+ ++EL E ++L +++
Sbjct: 1471 RDRAEAEAREKETKALSL--------ARALEEALEAKEEL------ERTNKMLKAEMEDL 1516
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAEL 626
+ DD K V E ++ ++ + Q E++ + K +L + + L
Sbjct: 1517 VSSKDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 627 QRQLQ--LEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLE 684
+ Q + L+ +++QN +E+R +++ L E ++ ++ ++ + ++ EG+L+
Sbjct: 1573 KGQFERDLQARDEQN-EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDR--------EKGA--LIEELLQ 734
+ RE+ ++R LQ Q+ + EL+ A+ S D EK A L +L+Q
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 735 AKQDLQDLLIAKE----EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAE-- 788
++DL A++ E+E+L + L+ + AL++E + + +L+E+ + E
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSG-RNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 789 -LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE------- 840
++A+ + V +AT+ E L++ T E + L+ +N++L+ + E
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 841 --------LERRVAQLQRQIED-----------LKGDEAKAKETLKKYEGE--------- 872
LE ++AQL+ Q+E LK + K KE L + E E
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Query: 873 --------IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
++QL+ L A +E + + RR L+ EL+ A + +E L KL+
Sbjct: 1871 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1930
Query: 925 ESEQK 929
Q+
Sbjct: 1931 PPPQE 1935
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 262 bits (670), Expect = 1e-69
Identities = 237/945 (25%), Positives = 457/945 (48%), Gaps = 121/945 (12%)
Query: 430 LSQERRGKQSVGRTFAKLQGAAHGAS--CAHSRPPQPNIDGKVLETEGSQESTVIRAPSL 487
L +E + +Q + +T KL+G + S A + + ++ + E ++ + R
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095
Query: 488 GAQS----KKEEEVKTATATLM--------LQNRATATSPDSGAKKISVKTFPSASNTQA 535
AQ KK E+++ + L +N+A D G + ++KT +
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT-----ELED 1150
Query: 536 TPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGS 595
T D QQEL + +E IL L+E + ++ +IQ ++ + + +
Sbjct: 1151 TLDSTAAQQELRSKREQEV--NILKKTLEEEAKTHE-----------AQIQEMRQKHSQA 1197
Query: 596 AQGNNQACNSTSEVKDLLEQ-KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEEL 654
+ + T VK LE+ K L E EL ++++ ++ + + + +R+++ A L+EL
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257
Query: 655 RSQHNE---------------KVE-------------ENSTLQQRLEESEGELRKNLEEL 686
+ + NE +VE ++S L + E +L+ E L
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL 1317
Query: 687 FQVKMEREQHQTEIRDLQDQLSEMHDELDS---AKRSEDREKGALIEELLQAKQDLQDLL 743
+ ++ T+++ ++D+ + ++L+ AK + +++ L ++ K+ ++D +
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 744 IAKEEQEDLLRKRERELTALKGALKEEVSSHD----------QEMDKLKEQYDAELQALR 793
E E++ RK +++L L +E+V+++D QE+D L D + Q+
Sbjct: 1378 GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSAC 1437
Query: 794 ESVEEATKNVEVLASRSNTS-----EQDQAGTEMRVK-----LLQEENEKLQGRSEELER 843
++ K ++LA S E+D+A E R K L E+ + ELER
Sbjct: 1438 NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER 1497
Query: 844 RVAQLQRQIEDL---KGDEAKAKETLKK----YEGEIRQLEEALVHARKEEKEAVSARRA 896
Q + ++EDL K D K+ L+K E ++ +++ L E + A+
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557
Query: 897 LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI---EKL 953
LE L+A + + Q + + SE+ K++ + Q+R ++ E+E+ER + +KL
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR--QVREMEAELEDERKQRSMAVAARKKL 1615
Query: 954 QKEMADI------VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTA 1007
+ ++ D+ +R ++ +L + REL + + +E +A+++
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL 1675
Query: 1008 MKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQME 1067
M+ EM ++EEL +RA+ +A +R L + + K L + R ++E
Sbjct: 1676 KSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS----GKGALALEEKR---RLE 1728
Query: 1068 DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
+++QLE ELEEE+ N++L+++R+ ++ Q++Q+ +L ER+ Q E + LERQNK
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788
Query: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELV 1187
+LK ++ +EG+ +S + + +EA+IA+LE++L++E ++R RR E+K+K+++
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL 1848
Query: 1188 MQVDDEHLS---LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNE 1244
+QVDDE + DQ D+ S RLK +KRQ+EEAEEE R +S++KLQRELE+ + +
Sbjct: 1849 LQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD 1908
Query: 1245 HLQGQLNSMKKDLRLKKLPSKVL---------DDMDDDDDLSTDG 1280
+ +++S+K LR LP V D D++ D DG
Sbjct: 1909 AMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADG 1953
Score = 207 bits (526), Expect = 7e-53
Identities = 160/710 (22%), Positives = 346/710 (48%), Gaps = 42/710 (5%)
Query: 610 KDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQ 669
K L + K+K + +L+ +L+ E K +Q +++ R ++ + +L Q E + + L+
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075
Query: 670 QRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE---DREKG 726
+L + E EL+ L + + ++ +IR+L+ Q+SE+ ++L+S + S +++K
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135
Query: 727 ALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD 786
L EEL K +L+D L + Q++L KRE+E+ LK L+EE +H+ ++ ++++++
Sbjct: 1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 787 AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVA 846
++ L E +E+ + L T E ++ VK+L + + + +++E ++
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255
Query: 847 QLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQG 906
+LQ + + + + + + K + E+ + L + + + ALE++L+ Q
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE 1315
Query: 907 NLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT 966
L + +++ LS KLK+ ++K R E E + +L K I L ++AD+ +
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375
Query: 967 STLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQR 1026
S L+ +E K K +++L + ++ +EK +K T ++Q E+ + +L D+QR
Sbjct: 1376 SVGCLET-AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL-DHQR 1433
Query: 1027 AQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRL-VKQMEDKVSQLEMELEEERNNSD 1085
L K+Q L E + AK + DR+ ++ E K L LEE
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA 1493
Query: 1086 LLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKE 1145
L + R +ME L + + +LE K +LE+Q +++K+++ LE +++++
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 1146 G---LVVQMEA-------------------------RIAELEDRLESEERDRANLQLSNR 1177
L V ++A ++ E+E LE E + R+ + +
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613
Query: 1178 RLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237
+LE +K+L +D S +D+ +L+ ++ Q+++ E+D +S++++ + +
Sbjct: 1614 KLEMDLKDLEAHID----SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 1238 EQMDMNEHLQGQLNSMKKDL----RLKKLPSKVLDDMDDDDDLSTDGGSL 1283
E + ++ ++ ++++L R K+ + D++ D+ S+ G+L
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Score = 161 bits (407), Expect = 4e-39
Identities = 181/797 (22%), Positives = 353/797 (44%), Gaps = 87/797 (10%)
Query: 533 TQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 592
T+ P L +QE EE ++ L + + T + L+ EK+Q +
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQS-QLMAEKLQLQEQ-- 888
Query: 593 AGSAQGNNQACNSTSEVKDLLEQKSKLTIEVA-ELQRQLQLEVKNQQNIKEERERMRANL 651
Q + C E++ L K + E+ +L+ +++ E + Q+++ E+++M+ N+
Sbjct: 889 ---LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI 945
Query: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH 711
+EL Q E+ LQ +E +L+K EE ++ + + E + L+D+++E
Sbjct: 946 QELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 712 DELDSAKRSEDREKGALIEELLQAKQ----DLQDLLIAKEEQEDLLRKRERELTALKGAL 767
L +E+ EK + +L + DL++ L +E+Q L K R+L L
Sbjct: 1006 TNL-----TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060
Query: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
++++ ++ +LK Q L E ++ A VE A++ N + + E ++ L
Sbjct: 1061 SDQIAELQAQIAELKMQ----LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKK--YEGEIRQLEEALVHARK 885
QE+ E + + E++ L ++E LK + ++TL + E+R K
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALK---TELEDTLDSTAAQQELRS---------K 1164
Query: 886 EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ----KEQLRRLKNEMEN 941
E+E ++ LE E + + + + Q+ Q E+L E+ EQ K L + K +EN
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN 1224
Query: 942 ERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYK--EKNRRELAE----MQRQLKE 995
ER L ++ L + D + +LQ ++ E+ R ELA+ +Q +L
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN 1284
Query: 996 KTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE------- 1048
T +S + K+ + +E +L+D Q E ++ L LK +E E
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344
Query: 1049 LEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQE 1108
LE + K + + + + +V+ ++ ++E+ + E + ++ +E L ++
Sbjct: 1345 LEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEK 1404
Query: 1109 RAARQDLECDKISLERQNKDLKSRIIH-------LEGSYRSSKEGLVVQ--MEARIAELE 1159
AA LE K L+++ DL + H LE + + L + + A+ AE
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464
Query: 1160 DRLESEERD------------------RANLQLSNRRLERKVKELVMQVDDEHLS---LT 1198
DR E+E R+ +A L+ N++ ++++L+ DD S L
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELE 1524
Query: 1199 DQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE-QMDMNEHLQG---QLNSMK 1254
K L +++ MK Q+EE E+E+ E +K +L+ L+ + LQG Q K
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK 1584
Query: 1255 KDL--RLKKLPSKVLDD 1269
K L +++++ +++ D+
Sbjct: 1585 KQLVRQVREMEAELEDE 1601
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 261 bits (668), Expect = 2e-69
Identities = 222/811 (27%), Positives = 405/811 (49%), Gaps = 73/811 (9%)
Query: 509 RATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETA--KQILYNYLKEG 566
+A+ + + +S + + + T D QQEL + +E A K+ L K
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 567 STDNDDATKRKVNLVFEKIQTLKS--RAAGSAQGNNQACNSTS-----EVKDLLEQKSKL 619
D +R + E + L+ R + + N Q + + EVK L + K+
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA-- 1248
Query: 620 TIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGEL 679
E +++L +V+ E +R+R L E S+ +++ STL + E+ +
Sbjct: 1249 --ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 680 RKN---LEELFQVKMEREQHQTE--------IRDLQDQ---LSEMHDELDSAKRSEDREK 725
K+ LE Q E Q +T IR L+++ L E +E + A+++ +++
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Query: 726 GALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHD---------- 775
AL +L K+ + D L E E+ +K ++ AL L+E+ ++D
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426
Query: 776 QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTS-----EQDQAGTEMRVK----- 825
QE+D L D + Q ++ K ++LA + S E+D+A E R K
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 826 -LLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR 884
L + E L+ + EE ER+ QL+ +EDL + + + + E R LE+ + R
Sbjct: 1487 SLARALEEALEAK-EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 885 KEEKEAVSARRALENELEAAQGNL-SQTTQEQKQLSEKLKEESEQK----EQLRRLKNEM 939
+ +E +A E+ + N+ + Q ++ L + ++ E+K +Q+R L+ E+
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605
Query: 940 ENERWHLGKTI---EKLQKEMADI---VEASRTSTLELQNQLDEYKEKNR---RELAEMQ 990
E+ER + +K++ ++ D+ +EA+ + E+ QL + + + + REL E +
Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEAR 1665
Query: 991 RQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELE 1050
E ++++S ++ E+ ++EEL +RA+ A +R ++ ++
Sbjct: 1666 ASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER---DELADEITNSAS 1722
Query: 1051 AKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERA 1110
KS L D++ RL E +++QLE ELEEE++N +LL++R ++ Q++ L EL ER+
Sbjct: 1723 GKSALLDEKRRL----EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERS 1778
Query: 1111 ARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRA 1170
A Q + + LERQNK+LK+++ LEG+ +S + + +EA+I +LE++LE E ++RA
Sbjct: 1779 AAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838
Query: 1171 NLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL---SLRLKAMKRQVEEAEEEIDRLES 1227
RR E+K+KE+ MQV+DE K+Q+ + R+K +KRQ+EEAEEE R +
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA 1898
Query: 1228 SKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
S++KLQREL++ + NE L +++++K LR
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 222 bits (566), Expect = 2e-57
Identities = 170/689 (24%), Positives = 343/689 (49%), Gaps = 24/689 (3%)
Query: 596 AQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELR 655
A+ ++Q + K+L + ++K + +++L+ +L+ E K +Q +++ + ++ +L+
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 656 SQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELD 715
Q E + L+ +L + E EL+ L + + +R+LQ Q++E+ ++ +
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 716 SAKRSE---DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVS 772
S K S +++K L EEL K +L+D L Q++L KRE+E+ LK AL+EE
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
+H+ ++ +++++ L+ L E +E+A + L E D VK+LQ+
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
+ + + ++L+ +V +L ++ + + E K + E+ + L A K+ +
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 893 ARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 952
+LE++L+ Q L + T+++ LS ++++ E+K L+ + E E R +L K +
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368
Query: 953 LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD 1012
LQ ++AD + L L+E K+K ++ + ++L+EK L +K T ++Q
Sbjct: 1369 LQSQLAD-TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 1013 EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRL-VKQMEDKVS 1071
E+ + +L D+QR L K+Q L E + A+ + DR+ ++ E K
Sbjct: 1428 ELDDLTVDL-DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 1072 QLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKS 1131
L LEE + + + R ME L + +LE K +LE+Q +++++
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546
Query: 1132 RIIHLEGSYRSSKEG---LVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVM 1188
++ LE +++++ L V M+A A+ E L++ RD N + R L ++V+EL
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT--RDEQN-EEKKRLLIKQVRELEA 1603
Query: 1189 QVDDEHLS---LTDQKDQLSLRLKAMKRQVEEAE-------EEIDRLESSKKKLQRELEE 1238
+++DE K ++ + LK ++ Q+E A +++ +L++ K QRELEE
Sbjct: 1604 ELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE 1663
Query: 1239 QMDMNEHLQGQLNSMKKDLRLKKLPSKVL 1267
+ + Q S + + +LK L +++L
Sbjct: 1664 ARASRDEIFAQ--SKESEKKLKSLEAEIL 1690
Score = 161 bits (408), Expect = 3e-39
Identities = 159/672 (23%), Positives = 305/672 (45%), Gaps = 80/672 (11%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
K K ++V + +LQ + + +KE++ ++ LEE+ +H + +EE + L ++L+
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQA 735
ELF E E+ + + + +L E+ +L+S E+ L E +
Sbjct: 900 T--------ELFA---EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948
Query: 736 KQDLQDLLIAKEEQEDLLRKRERELTALKGALK---------EEVSSHDQEMDKLKEQYD 786
+ +QDL +E+E +K + E + +K E+ +S + KL E
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Query: 787 AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL-------LQEENEKLQGRSE 839
AE + EE KN LA N E + E R+K L++ KL G +
Sbjct: 1009 AECSSQLAEEEEKAKN---LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065
Query: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALEN 899
+L+ ++A+LQ QI++LK AK +E L
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEEL--------------------------------- 1092
Query: 900 ELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
QG L++ E + LK E + Q+ L+ + E+E+ K EK ++++++
Sbjct: 1093 -----QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA-EKQKRDLSE 1146
Query: 960 IVEASRT---STLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL 1016
+EA +T TL+ E + K +E+AE+++ L+E+T E +++ M+ + L
Sbjct: 1147 ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE-AQIQDMRQRHATAL 1205
Query: 1017 ME--EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLE 1074
E E+L +R + +Q LE K+L E++ +K + K+++ +V +L
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265
Query: 1075 MELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRII 1134
++ E L+E+ S+ + +++ + L + D SLE Q +D + ++
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ-ELL 1324
Query: 1135 HLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDE- 1193
E + + + Q+E L+++ E EE R NL+ L+ ++ + +VDD+
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384
Query: 1194 --HLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE-QMDMNEHLQGQL 1250
SL + K +L +A+ +++EE D+LE +K +LQ+EL++ +D++ Q
Sbjct: 1385 GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS 1444
Query: 1251 NSMKKDLRLKKL 1262
N KK + +L
Sbjct: 1445 NLEKKQKKFDQL 1456
Score = 153 bits (387), Expect = 9e-37
Identities = 134/566 (23%), Positives = 276/566 (48%), Gaps = 34/566 (6%)
Query: 729 IEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDK---LKEQY 785
++ LLQ + ++L + + E+LL+ +E++ T ++G L+E H Q +++ L EQ
Sbjct: 841 VKPLLQVTRQEEEL---QAKDEELLKVKEKQ-TKVEGELEEMERKHQQLLEEKNILAEQL 896
Query: 786 DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRV 845
AE + E+ E + LA++ E+ E RV+ +E N+ LQ ++++ +
Sbjct: 897 QAETELFAEAEEMRAR----LAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 846 AQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQ 905
L+ Q+++ +G K + E +I+++EE ++ + + + ++ +E+ +
Sbjct: 953 QDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 906 GNLSQTTQEQKQLSE-KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964
L++ ++ K L++ + K+E + RLK E E R L K KL E D+
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE-EKTRQELEKAKRKLDGETTDL---- 1067
Query: 965 RTSTLELQNQLDEYKEKNRRELAEMQRQL---KEKTLEAEKSRLTAMKMQDEMRLMEEEL 1021
+ ELQ Q+DE K + ++ E+Q L ++TL + ++Q ++ ++E+
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF 1127
Query: 1022 RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE- 1080
+ ++++A +++ L + L+ L+ ELE + L + E +V++L+ LEEE
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 1081 RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY 1140
+N+ + + R +E+L +L Q + + +LE +K LE NK+L + L+
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ-QV 1246
Query: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD-EHLSLTD 1199
++ E +++A++ EL ++ +R R L +L+ ++ + +++ E +
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 1200 QKDQLSLR---------LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQL 1250
KD SL L+ RQ I +LE K LQ + EE+ + ++L+ Q+
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Query: 1251 NSMKKDLRLKKLPSKVLDDMDDDDDL 1276
+++ L K KV DD+ + L
Sbjct: 1367 LALQSQLADTK--KKVDDDLGTIESL 1390
Score = 148 bits (374), Expect = 3e-35
Identities = 159/731 (21%), Positives = 314/731 (42%), Gaps = 82/731 (11%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRAN-------LEELRSQHNE 660
E++++ + +L E L QLQ E + +E R R+ A L +L S+ E
Sbjct: 874 ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE 933
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE---LDSA 717
+ E N LQ ++ + ++ E+L + + R++ Q E + ++ +M +E L+
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993
Query: 718 KRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQE 777
+EK + + + + L + + + K+E ++ L+ LK+E + QE
Sbjct: 994 NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR-QE 1052
Query: 778 MDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGR 837
++K K + D E L++ + E ++ L + E++ G L + ++E L
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGA-----LARGDDETLHKN 1107
Query: 838 S-----EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA--------- 883
+ EL+ ++A+LQ E K KA++ + E+ L+ L
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 884 --RKEEKEAVSARRALENELEAAQGNLSQTTQEQ----KQLSEKLKEESEQKEQLRRLKN 937
K E+E ++ALE E + + + Q ++LSE+L++ K L + K
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 938 EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR--ELAE----MQR 991
+E + L ++ LQ+ A+ + ++Q + E +R ELAE +Q
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA 1051
+L + E++ +K + +E +L+D Q E ++ L ++ LE E +
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 1052 KSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSD-------LLSERISRSREQMEQLRNE 1104
+++ K +E +V L+ +L + + D L E + + E L
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407
Query: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIH-------LEGSYRSSKEGLVVQ--MEARI 1155
L ++ A LE K L+++ DL + H LE + + L + + AR
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467
Query: 1156 AELEDRLESEERDRANLQLS------------------NRRLERKVKELVMQVDDEHLS- 1196
AE DR E+E R++ LS N++L +++L+ DD +
Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527
Query: 1197 --LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQ---RELEEQMDMNEHLQGQLN 1251
L K L +++ M+ Q+EE E+E+ E +K +L+ + ++ Q + + + + N
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 1252 SMKKDLRLKKL 1262
KK L +K++
Sbjct: 1588 EEKKRLLIKQV 1598
Score = 32.3 bits (72), Expect = 3.0
Identities = 45/207 (21%), Positives = 85/207 (41%), Gaps = 37/207 (17%)
Query: 494 EEEVKTATATLMLQN---RATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQT 550
EEE++ + + L N R T D+ +++ + + + A +Q+L +Q
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA-------RQQLERQN 1794
Query: 551 NEETAK-QILYNYLKEGSTDNDDATKRKVNLVFEKI-QTLKSRAAGSAQGNNQACNSTSE 608
E AK Q L +K A + K+ + E++ Q K RAA N + +
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA----NKLVRRTEKK 1850
Query: 609 VKDLL--------------EQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEEL 654
+K++ EQ K + +L+RQL+ +EE R A+ +L
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE-------EAEEEATRANASRRKL 1903
Query: 655 RSQHNEKVEENSTLQQRLEESEGELRK 681
+ + ++ E N L + + + LR+
Sbjct: 1904 QRELDDATEANEGLSREVSTLKNRLRR 1930
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 216 bits (550), Expect = 1e-55
Identities = 205/894 (22%), Positives = 409/894 (45%), Gaps = 72/894 (8%)
Query: 430 LSQERRGKQSVGRTFAKLQGAAHGAS--CAHSRPPQPNIDGKVLETEGSQESTVIRAPSL 487
L +E +G+Q + + +L G + + + ++ E ++ + RA
Sbjct: 1068 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1127
Query: 488 GA------QSKKEEEVKTATATLMLQN-RATATSPDSGAKKISVKTFPSASNTQATPDLL 540
G +S +E + A A L++ R T + + + + + T D
Sbjct: 1128 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1187
Query: 541 KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATK----RKVNLVFEKIQTLKSRAAGSA 596
QQEL + +E + L L+E + ++ A + R + E + L+ G
Sbjct: 1188 NAQQELRSKREQEVTE--LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1245
Query: 597 QGNNQACNSTSEVKDLLEQKSKLTI---EVAELQRQLQLEVKNQQN-----------IKE 642
+EV +L + S L E + +R+L+L+++ Q E
Sbjct: 1246 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1305
Query: 643 ERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRD 702
+ +R +A LE + NE + L + L +E +L E L + + + +R
Sbjct: 1306 KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1365
Query: 703 LQDQLSEMHDELD---SAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERE 759
++ + + + ++L+ +A+ RE +L + ++ ++ A E E+ R+ RE
Sbjct: 1366 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1425
Query: 760 LTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAG 819
AL L E+ + D+ +++ + + EL +E+ + V L + +Q A
Sbjct: 1426 AEALTQRLAEKTETVDR-LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484
Query: 820 TEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEA 879
+ V EE E+ + E E R L R +E+ E +A+E L++ +R EA
Sbjct: 1485 EKAAVLRAVEERERAEAEGREREARALSLTRALEE----EQEAREELERQNRALRAELEA 1540
Query: 880 LVHARKEEKEAV-SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE 938
L+ ++ + ++V RA +AA +Q T+ + +L+ + + ++ LK +
Sbjct: 1541 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1600
Query: 939 MENERWHLGKTIEKLQKEMADIV---EASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE 995
E + + E+ ++++A + E R + + ++K EL E++ Q+
Sbjct: 1601 HERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1660
Query: 996 KTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYEL------ 1049
E++ KMQ +M+ + E+ + + +++E ++ + E+ LK LE E+
Sbjct: 1661 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1720
Query: 1050 -----EAKSHLKDDRSRLV-----------------KQMEDKVSQLEMELEEERNNSDLL 1087
A+ + DR + +Q+E ++ QLE ELEEE++NS+LL
Sbjct: 1721 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1780
Query: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
++R + Q+E L EL ER+ E + LERQ ++L+ R+ + R+ +
Sbjct: 1781 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1840
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL---SLTDQKDQL 1204
+ +E+++A+ E++LE E R+R RR E+++KE+V+QV++E L DQ ++
Sbjct: 1841 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1900
Query: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
+LR+K +KRQ+EEAEEE R ++ +++LQRELE+ + E + ++ +++ LR
Sbjct: 1901 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR 1954
Score = 154 bits (389), Expect = 5e-37
Identities = 185/817 (22%), Positives = 352/817 (43%), Gaps = 143/817 (17%)
Query: 584 KIQTLKSRAAGSAQGNNQACNSTSEVKD-LLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 642
+++ ++R A + + C E + L +K +L + V+EL+ ++ E + + ++
Sbjct: 909 QLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT 968
Query: 643 ERERMRANLEELRS-----------------------------------QHNEKVEENST 667
E++R++ +++EL + Q+++ +E
Sbjct: 969 EKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL 1028
Query: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQL---SEMHDELDSAKRSEDRE 724
L+ RL E + + E++ + R +++ I D++D+L + EL+ KR D E
Sbjct: 1029 LEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE 1088
Query: 725 KGALIEELLQAKQDLQDL---LIAKEEQ--------ED------LLRKRERELTALKGAL 767
L E++++ +Q ++L L KEE+ ED L K RE A
Sbjct: 1089 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEA 1148
Query: 768 KEEVSSH---DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRV 824
+E++ S + +K + EL+ALR +E+ + A + S+++Q TE++
Sbjct: 1149 QEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN--AQQELRSKREQEVTELK- 1205
Query: 825 KLLQEENEKLQGRSEELERR----VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
K L+EE + +EL +R + +L Q+E + + ++T E E+ +L L
Sbjct: 1206 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1265
Query: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEME 940
+ +E RR LE +L+ QG + + + +EKL+ + E + NE E
Sbjct: 1266 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1325
Query: 941 NERWHLGKTIEKLQKEMADIVE------------ASRTSTLE-----LQNQLDE---YKE 980
++ L K + + ++ D E SR +E L+ QL+E +E
Sbjct: 1326 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE 1385
Query: 981 KNRRELAEMQRQLKE--KTLEAEKSRLTA-----MKMQDEMRLMEEELRDYQRAQDEALT 1033
+ REL Q QL E + E E L A + E + + L + D
Sbjct: 1386 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLER 1445
Query: 1034 KRQLLEQTLKDLEYELEAKSHL---KDDRSRLVKQM--EDKVSQLEMELEEER-----NN 1083
R+ L+Q L D +LE + L + + R Q+ E+K + L E ER
Sbjct: 1446 GRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE 1505
Query: 1084 SDLLSERISRSREQMEQLRNEL-LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 1142
+ + ++R+ E+ ++ R EL Q RA R +LE +L D+ + LE + R
Sbjct: 1506 REARALSLTRALEEEQEAREELERQNRALRAELE----ALLSSKDDVGKSVHELERACRV 1561
Query: 1143 SKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL---------------ERKVKELV 1187
+++ + A++ ELED L + E + L+++ + L E + ++L
Sbjct: 1562 AEQA-ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA 1620
Query: 1188 MQVDDEHLSLTDQKDQLSLRLKAMKR-----------------QVEEAEEEIDRLESSKK 1230
Q+ D + +++ Q +L + A K+ EEA +++ ++++ K
Sbjct: 1621 KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMK 1680
Query: 1231 KLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVL 1267
+L RE+EE E + Q +K RLK L ++VL
Sbjct: 1681 ELWREVEETRTSREEIFSQNRESEK--RLKGLEAEVL 1715
Score = 134 bits (337), Expect = 6e-31
Identities = 163/691 (23%), Positives = 304/691 (43%), Gaps = 81/691 (11%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
+V++L +Q ++ EV ELQ ++ A LEE R++ E++ +
Sbjct: 888 KVQELQQQSAR---EVGELQGRV------------------AQLEEERARLAEQLRAEAE 926
Query: 668 LQQRLEESEGELRKNLEELFQVKMERE-----------QHQTEIRDLQDQLSEMHDELDS 716
L EE+ G L +EL V E E Q QTE + LQ + E+ L++
Sbjct: 927 LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 986
Query: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKR---ERELTALKGALKEEVSS 773
+ + + + + + K+ +DLL+ +++ L ++R E L EE
Sbjct: 987 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE-EE 1045
Query: 774 HDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
+ ++KL+ +Y+A + + + + + K + L + + + + ++ Q+ E+
Sbjct: 1046 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1105
Query: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
L+ + E + + ED G A+ ++L++ + + + +E L R +A
Sbjct: 1106 LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ 1165
Query: 894 RRALENELEAAQGNLSQT---TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
RR L ELEA +G L T T Q++L S++++++ LK +E E +
Sbjct: 1166 RRDLGEELEALRGELEDTLDSTNAQQEL------RSKREQEVTELKKTLEEETRIHEAAV 1219
Query: 951 EKLQKEMADIVEASRTSTLELQNQLDEYKE-KNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
++L++ + EL QL++ + K E + + + L AE S L +
Sbjct: 1220 QELRQRHGQALG-------ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTAR 1272
Query: 1010 MQDEMRLMEEELR---------DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060
+ E R EL+ D +RA+ EA K L++ +LE A + +
Sbjct: 1273 QEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK---LQRAQAELENVSGALNEAESKTI 1329
Query: 1061 RLVKQMEDKVSQLE--MELEEERNNSDL-LSERISRSREQMEQLRNELLQERAARQDLEC 1117
RL K++ +QL EL +E + L L R+ + LR +L +E AAR+
Sbjct: 1330 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1389
Query: 1118 DKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE-LEDRLESEERDRANLQLSN 1176
+ + + Q + + R G+ + +E + AR AE L RL + L+
Sbjct: 1390 ELQTAQAQLSEWRRRQEEEAGALEAGEEAR--RRAAREAEALTQRLAEKTETVDRLERGR 1447
Query: 1177 RRLERKVKELVMQVDDEH--LSLTDQK----DQLSLRLK-AMKRQVEE---AEEEIDRLE 1226
RRL++++ + M ++ + +S ++K DQL K A+ R VEE AE E E
Sbjct: 1448 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1507
Query: 1227 SSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
+ L R LEE+ + E L+ Q +++ +L
Sbjct: 1508 ARALSLTRALEEEQEAREELERQNRALRAEL 1538
Score = 129 bits (323), Expect = 2e-29
Identities = 137/625 (21%), Positives = 276/625 (44%), Gaps = 70/625 (11%)
Query: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE 747
+V R Q ++++LQ Q + EL + E+ L E+L + L E
Sbjct: 877 EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE----LCAEAE 932
Query: 748 EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLA 807
E L R++EL + L+ V E ++ Q E + L++ ++E ++E
Sbjct: 933 ETRGRLAARKQELELVVSELEARVG----EEEECSRQMQTEKKRLQQHIQELEAHLEAEE 988
Query: 808 SRSNTSEQDQAGTEMRVK-------LLQEENEKLQGRSEELERRVAQLQRQ--------- 851
+ ++ TE ++K LL+++N KL + LE R+A+ Q
Sbjct: 989 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1048
Query: 852 ---------------IEDLKGDEAKAKETLKK----YEGEIRQLEEALVHARKEEKEAVS 892
+ED E K ++ L+K +GE +L+E +V ++ +E +
Sbjct: 1049 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1108
Query: 893 ARRALENELEAA-------QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945
E EL+AA G +Q + ++ L E E E R + + E +R
Sbjct: 1109 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1168
Query: 946 LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRL 1005
LG+ +E L+ E+ D TL+ N E + K +E+ E+++ L+E+T ++ +
Sbjct: 1169 LGEELEALRGELED--------TLDSTNAQQELRSKREQEVTELKKTLEEET-RIHEAAV 1219
Query: 1006 TAMKMQDEMRLME--EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLV 1063
++ + L E E+L +R + R LE + +L EL + + + +
Sbjct: 1220 QELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR 1279
Query: 1064 KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
+++E ++ +++ + +E++ R++ ++E + L + + L + S E
Sbjct: 1280 RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTE 1339
Query: 1124 RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE--ERDRANLQLSNRRLER 1181
Q D + ++ E + + V MEA A L ++LE E R+RA +L + +
Sbjct: 1340 AQLHDAQ-ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL--QTAQA 1396
Query: 1182 KVKELVMQVDDEHLSL---TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE 1238
++ E + ++E +L + + + + +A+ +++ E E +DRLE +++LQ+EL++
Sbjct: 1397 QLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD 1456
Query: 1239 -QMDMNEHLQGQLNSMKKDLRLKKL 1262
MD+ + Q KK + +L
Sbjct: 1457 ATMDLEQQRQLVSTLEKKQRKFDQL 1481
Score = 123 bits (309), Expect = 1e-27
Identities = 146/645 (22%), Positives = 282/645 (43%), Gaps = 95/645 (14%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKN-QQNIKEE---RERMRANLEELRSQHNE--- 660
+ ++LL+++++ + + R ++ E ++ ++EE RER L+ ++Q +E
Sbjct: 1344 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRR 1403
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRD-LQDQLSEMHDELDSAKR 719
+ EE + + EE+ + E L Q R +TE D L+ + ELD A
Sbjct: 1404 RQEEEAGALEAGEEARRRAAREAEALTQ----RLAEKTETVDRLERGRRRLQQELDDA-- 1457
Query: 720 SEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKG------------AL 767
+ D E+ + L+ KQ D L+A+E+ L ERE +G AL
Sbjct: 1458 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1517
Query: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
+EE + + E+++ AEL+AL S ++ K+V L +EQ A ++R ++
Sbjct: 1518 EEEQEARE-ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQ--AANDLRAQVT 1574
Query: 828 QEENE------------------------KLQGRSEELERRVAQLQRQIED--LKGDEAK 861
+ E+E LQGR E E R QL +Q+ D ++ DE +
Sbjct: 1575 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1634
Query: 862 AKETL-----KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQK 916
+ TL KK EGE+ +L+ + A + ++EAV R ++ +++ + +T ++
Sbjct: 1635 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1694
Query: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQK---EMADIV---EASRTSTLE 970
++ + +E ++ + L ++ E + + Q+ EMAD V S+ + LE
Sbjct: 1695 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1754
Query: 971 LQNQLDEYKEKNRRELAEMQR--------------QLKEKTLEAEKSRLTAMKMQDEMRL 1016
+ QL+ + EL E Q Q++ T E R + K + +
Sbjct: 1755 EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1814
Query: 1017 ME---EELRDYQRAQDEALTKRQ-----LLEQTLKDLEYELEAKSHLKDDRSRLVKQMED 1068
+E +ELR +D R LE L E +LE ++ + +LV++ E
Sbjct: 1815 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1874
Query: 1069 KVSQLEMELEEERNNSDLLSE-------RISRSREQMEQLRNELLQERAARQDLECDKIS 1121
++ ++ +++EEER +D L + R+ + + Q+E+ E + +A R+ L+ +
Sbjct: 1875 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1934
Query: 1122 LERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEE 1166
+ + + + L R + ++ LE+ + S+E
Sbjct: 1935 VTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDE 1979
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 216 bits (550), Expect = 1e-55
Identities = 205/894 (22%), Positives = 409/894 (45%), Gaps = 72/894 (8%)
Query: 430 LSQERRGKQSVGRTFAKLQGAAHGAS--CAHSRPPQPNIDGKVLETEGSQESTVIRAPSL 487
L +E +G+Q + + +L G + + + ++ E ++ + RA
Sbjct: 1060 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1119
Query: 488 GA------QSKKEEEVKTATATLMLQN-RATATSPDSGAKKISVKTFPSASNTQATPDLL 540
G +S +E + A A L++ R T + + + + + T D
Sbjct: 1120 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1179
Query: 541 KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATK----RKVNLVFEKIQTLKSRAAGSA 596
QQEL + +E + L L+E + ++ A + R + E + L+ G
Sbjct: 1180 NAQQELRSKREQEVTE--LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1237
Query: 597 QGNNQACNSTSEVKDLLEQKSKLTI---EVAELQRQLQLEVKNQQN-----------IKE 642
+EV +L + S L E + +R+L+L+++ Q E
Sbjct: 1238 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1297
Query: 643 ERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRD 702
+ +R +A LE + NE + L + L +E +L E L + + + +R
Sbjct: 1298 KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1357
Query: 703 LQDQLSEMHDELD---SAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERE 759
++ + + + ++L+ +A+ RE +L + ++ ++ A E E+ R+ RE
Sbjct: 1358 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1417
Query: 760 LTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAG 819
AL L E+ + D+ +++ + + EL +E+ + V L + +Q A
Sbjct: 1418 AEALTQRLAEKTETVDR-LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476
Query: 820 TEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEA 879
+ V EE E+ + E E R L R +E+ E +A+E L++ +R EA
Sbjct: 1477 EKAAVLRAVEERERAEAEGREREARALSLTRALEE----EQEAREELERQNRALRAELEA 1532
Query: 880 LVHARKEEKEAV-SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE 938
L+ ++ + ++V RA +AA +Q T+ + +L+ + + ++ LK +
Sbjct: 1533 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1592
Query: 939 MENERWHLGKTIEKLQKEMADIV---EASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE 995
E + + E+ ++++A + E R + + ++K EL E++ Q+
Sbjct: 1593 HERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1652
Query: 996 KTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYEL------ 1049
E++ KMQ +M+ + E+ + + +++E ++ + E+ LK LE E+
Sbjct: 1653 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1712
Query: 1050 -----EAKSHLKDDRSRLV-----------------KQMEDKVSQLEMELEEERNNSDLL 1087
A+ + DR + +Q+E ++ QLE ELEEE++NS+LL
Sbjct: 1713 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1772
Query: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
++R + Q+E L EL ER+ E + LERQ ++L+ R+ + R+ +
Sbjct: 1773 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1832
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL---SLTDQKDQL 1204
+ +E+++A+ E++LE E R+R RR E+++KE+V+QV++E L DQ ++
Sbjct: 1833 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1892
Query: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
+LR+K +KRQ+EEAEEE R ++ +++LQRELE+ + E + ++ +++ LR
Sbjct: 1893 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR 1946
Score = 154 bits (389), Expect = 5e-37
Identities = 185/817 (22%), Positives = 352/817 (43%), Gaps = 143/817 (17%)
Query: 584 KIQTLKSRAAGSAQGNNQACNSTSEVKD-LLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 642
+++ ++R A + + C E + L +K +L + V+EL+ ++ E + + ++
Sbjct: 901 QLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT 960
Query: 643 ERERMRANLEELRS-----------------------------------QHNEKVEENST 667
E++R++ +++EL + Q+++ +E
Sbjct: 961 EKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL 1020
Query: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQL---SEMHDELDSAKRSEDRE 724
L+ RL E + + E++ + R +++ I D++D+L + EL+ KR D E
Sbjct: 1021 LEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE 1080
Query: 725 KGALIEELLQAKQDLQDL---LIAKEEQ--------ED------LLRKRERELTALKGAL 767
L E++++ +Q ++L L KEE+ ED L K RE A
Sbjct: 1081 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEA 1140
Query: 768 KEEVSSH---DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRV 824
+E++ S + +K + EL+ALR +E+ + A + S+++Q TE++
Sbjct: 1141 QEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN--AQQELRSKREQEVTELK- 1197
Query: 825 KLLQEENEKLQGRSEELERR----VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
K L+EE + +EL +R + +L Q+E + + ++T E E+ +L L
Sbjct: 1198 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1257
Query: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEME 940
+ +E RR LE +L+ QG + + + +EKL+ + E + NE E
Sbjct: 1258 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1317
Query: 941 NERWHLGKTIEKLQKEMADIVE------------ASRTSTLE-----LQNQLDE---YKE 980
++ L K + + ++ D E SR +E L+ QL+E +E
Sbjct: 1318 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE 1377
Query: 981 KNRRELAEMQRQLKE--KTLEAEKSRLTA-----MKMQDEMRLMEEELRDYQRAQDEALT 1033
+ REL Q QL E + E E L A + E + + L + D
Sbjct: 1378 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLER 1437
Query: 1034 KRQLLEQTLKDLEYELEAKSHL---KDDRSRLVKQM--EDKVSQLEMELEEER-----NN 1083
R+ L+Q L D +LE + L + + R Q+ E+K + L E ER
Sbjct: 1438 GRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE 1497
Query: 1084 SDLLSERISRSREQMEQLRNEL-LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 1142
+ + ++R+ E+ ++ R EL Q RA R +LE +L D+ + LE + R
Sbjct: 1498 REARALSLTRALEEEQEAREELERQNRALRAELE----ALLSSKDDVGKSVHELERACRV 1553
Query: 1143 SKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL---------------ERKVKELV 1187
+++ + A++ ELED L + E + L+++ + L E + ++L
Sbjct: 1554 AEQA-ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA 1612
Query: 1188 MQVDDEHLSLTDQKDQLSLRLKAMKR-----------------QVEEAEEEIDRLESSKK 1230
Q+ D + +++ Q +L + A K+ EEA +++ ++++ K
Sbjct: 1613 KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMK 1672
Query: 1231 KLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVL 1267
+L RE+EE E + Q +K RLK L ++VL
Sbjct: 1673 ELWREVEETRTSREEIFSQNRESEK--RLKGLEAEVL 1707
Score = 134 bits (337), Expect = 6e-31
Identities = 163/691 (23%), Positives = 304/691 (43%), Gaps = 81/691 (11%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
+V++L +Q ++ EV ELQ ++ A LEE R++ E++ +
Sbjct: 880 KVQELQQQSAR---EVGELQGRV------------------AQLEEERARLAEQLRAEAE 918
Query: 668 LQQRLEESEGELRKNLEELFQVKMERE-----------QHQTEIRDLQDQLSEMHDELDS 716
L EE+ G L +EL V E E Q QTE + LQ + E+ L++
Sbjct: 919 LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 978
Query: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKR---ERELTALKGALKEEVSS 773
+ + + + + + K+ +DLL+ +++ L ++R E L EE
Sbjct: 979 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE-EE 1037
Query: 774 HDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
+ ++KL+ +Y+A + + + + + K + L + + + + ++ Q+ E+
Sbjct: 1038 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1097
Query: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
L+ + E + + ED G A+ ++L++ + + + +E L R +A
Sbjct: 1098 LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ 1157
Query: 894 RRALENELEAAQGNLSQT---TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
RR L ELEA +G L T T Q++L S++++++ LK +E E +
Sbjct: 1158 RRDLGEELEALRGELEDTLDSTNAQQEL------RSKREQEVTELKKTLEEETRIHEAAV 1211
Query: 951 EKLQKEMADIVEASRTSTLELQNQLDEYKE-KNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
++L++ + EL QL++ + K E + + + L AE S L +
Sbjct: 1212 QELRQRHGQALG-------ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTAR 1264
Query: 1010 MQDEMRLMEEELR---------DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060
+ E R EL+ D +RA+ EA K L++ +LE A + +
Sbjct: 1265 QEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK---LQRAQAELENVSGALNEAESKTI 1321
Query: 1061 RLVKQMEDKVSQLE--MELEEERNNSDL-LSERISRSREQMEQLRNELLQERAARQDLEC 1117
RL K++ +QL EL +E + L L R+ + LR +L +E AAR+
Sbjct: 1322 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1381
Query: 1118 DKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE-LEDRLESEERDRANLQLSN 1176
+ + + Q + + R G+ + +E + AR AE L RL + L+
Sbjct: 1382 ELQTAQAQLSEWRRRQEEEAGALEAGEEAR--RRAAREAEALTQRLAEKTETVDRLERGR 1439
Query: 1177 RRLERKVKELVMQVDDEH--LSLTDQK----DQLSLRLK-AMKRQVEE---AEEEIDRLE 1226
RRL++++ + M ++ + +S ++K DQL K A+ R VEE AE E E
Sbjct: 1440 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1499
Query: 1227 SSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
+ L R LEE+ + E L+ Q +++ +L
Sbjct: 1500 ARALSLTRALEEEQEAREELERQNRALRAEL 1530
Score = 129 bits (323), Expect = 2e-29
Identities = 137/625 (21%), Positives = 276/625 (44%), Gaps = 70/625 (11%)
Query: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE 747
+V R Q ++++LQ Q + EL + E+ L E+L + L E
Sbjct: 869 EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE----LCAEAE 924
Query: 748 EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLA 807
E L R++EL + L+ V E ++ Q E + L++ ++E ++E
Sbjct: 925 ETRGRLAARKQELELVVSELEARVG----EEEECSRQMQTEKKRLQQHIQELEAHLEAEE 980
Query: 808 SRSNTSEQDQAGTEMRVK-------LLQEENEKLQGRSEELERRVAQLQRQ--------- 851
+ ++ TE ++K LL+++N KL + LE R+A+ Q
Sbjct: 981 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1040
Query: 852 ---------------IEDLKGDEAKAKETLKK----YEGEIRQLEEALVHARKEEKEAVS 892
+ED E K ++ L+K +GE +L+E +V ++ +E +
Sbjct: 1041 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1100
Query: 893 ARRALENELEAA-------QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945
E EL+AA G +Q + ++ L E E E R + + E +R
Sbjct: 1101 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1160
Query: 946 LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRL 1005
LG+ +E L+ E+ D TL+ N E + K +E+ E+++ L+E+T ++ +
Sbjct: 1161 LGEELEALRGELED--------TLDSTNAQQELRSKREQEVTELKKTLEEET-RIHEAAV 1211
Query: 1006 TAMKMQDEMRLME--EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLV 1063
++ + L E E+L +R + R LE + +L EL + + + +
Sbjct: 1212 QELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR 1271
Query: 1064 KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
+++E ++ +++ + +E++ R++ ++E + L + + L + S E
Sbjct: 1272 RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTE 1331
Query: 1124 RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE--ERDRANLQLSNRRLER 1181
Q D + ++ E + + V MEA A L ++LE E R+RA +L + +
Sbjct: 1332 AQLHDAQ-ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL--QTAQA 1388
Query: 1182 KVKELVMQVDDEHLSL---TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE 1238
++ E + ++E +L + + + + +A+ +++ E E +DRLE +++LQ+EL++
Sbjct: 1389 QLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD 1448
Query: 1239 -QMDMNEHLQGQLNSMKKDLRLKKL 1262
MD+ + Q KK + +L
Sbjct: 1449 ATMDLEQQRQLVSTLEKKQRKFDQL 1473
Score = 123 bits (309), Expect = 1e-27
Identities = 146/645 (22%), Positives = 282/645 (43%), Gaps = 95/645 (14%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKN-QQNIKEE---RERMRANLEELRSQHNE--- 660
+ ++LL+++++ + + R ++ E ++ ++EE RER L+ ++Q +E
Sbjct: 1336 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRR 1395
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRD-LQDQLSEMHDELDSAKR 719
+ EE + + EE+ + E L Q R +TE D L+ + ELD A
Sbjct: 1396 RQEEEAGALEAGEEARRRAAREAEALTQ----RLAEKTETVDRLERGRRRLQQELDDA-- 1449
Query: 720 SEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKG------------AL 767
+ D E+ + L+ KQ D L+A+E+ L ERE +G AL
Sbjct: 1450 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1509
Query: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
+EE + + E+++ AEL+AL S ++ K+V L +EQ A ++R ++
Sbjct: 1510 EEEQEARE-ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQ--AANDLRAQVT 1566
Query: 828 QEENE------------------------KLQGRSEELERRVAQLQRQIED--LKGDEAK 861
+ E+E LQGR E E R QL +Q+ D ++ DE +
Sbjct: 1567 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1626
Query: 862 AKETL-----KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQK 916
+ TL KK EGE+ +L+ + A + ++EAV R ++ +++ + +T ++
Sbjct: 1627 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1686
Query: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQK---EMADIV---EASRTSTLE 970
++ + +E ++ + L ++ E + + Q+ EMAD V S+ + LE
Sbjct: 1687 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1746
Query: 971 LQNQLDEYKEKNRRELAEMQR--------------QLKEKTLEAEKSRLTAMKMQDEMRL 1016
+ QL+ + EL E Q Q++ T E R + K + +
Sbjct: 1747 EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1806
Query: 1017 ME---EELRDYQRAQDEALTKRQ-----LLEQTLKDLEYELEAKSHLKDDRSRLVKQMED 1068
+E +ELR +D R LE L E +LE ++ + +LV++ E
Sbjct: 1807 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1866
Query: 1069 KVSQLEMELEEERNNSDLLSE-------RISRSREQMEQLRNELLQERAARQDLECDKIS 1121
++ ++ +++EEER +D L + R+ + + Q+E+ E + +A R+ L+ +
Sbjct: 1867 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1926
Query: 1122 LERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEE 1166
+ + + + L R + ++ LE+ + S+E
Sbjct: 1927 VTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDE 1971
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 216 bits (550), Expect = 1e-55
Identities = 205/894 (22%), Positives = 409/894 (45%), Gaps = 72/894 (8%)
Query: 430 LSQERRGKQSVGRTFAKLQGAAHGAS--CAHSRPPQPNIDGKVLETEGSQESTVIRAPSL 487
L +E +G+Q + + +L G + + + ++ E ++ + RA
Sbjct: 1101 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1160
Query: 488 GA------QSKKEEEVKTATATLMLQN-RATATSPDSGAKKISVKTFPSASNTQATPDLL 540
G +S +E + A A L++ R T + + + + + T D
Sbjct: 1161 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1220
Query: 541 KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATK----RKVNLVFEKIQTLKSRAAGSA 596
QQEL + +E + L L+E + ++ A + R + E + L+ G
Sbjct: 1221 NAQQELRSKREQEVTE--LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1278
Query: 597 QGNNQACNSTSEVKDLLEQKSKLTI---EVAELQRQLQLEVKNQQN-----------IKE 642
+EV +L + S L E + +R+L+L+++ Q E
Sbjct: 1279 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1338
Query: 643 ERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRD 702
+ +R +A LE + NE + L + L +E +L E L + + + +R
Sbjct: 1339 KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1398
Query: 703 LQDQLSEMHDELD---SAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERE 759
++ + + + ++L+ +A+ RE +L + ++ ++ A E E+ R+ RE
Sbjct: 1399 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1458
Query: 760 LTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAG 819
AL L E+ + D+ +++ + + EL +E+ + V L + +Q A
Sbjct: 1459 AEALTQRLAEKTETVDR-LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1517
Query: 820 TEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEA 879
+ V EE E+ + E E R L R +E+ E +A+E L++ +R EA
Sbjct: 1518 EKAAVLRAVEERERAEAEGREREARALSLTRALEE----EQEAREELERQNRALRAELEA 1573
Query: 880 LVHARKEEKEAV-SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE 938
L+ ++ + ++V RA +AA +Q T+ + +L+ + + ++ LK +
Sbjct: 1574 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1633
Query: 939 MENERWHLGKTIEKLQKEMADIV---EASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE 995
E + + E+ ++++A + E R + + ++K EL E++ Q+
Sbjct: 1634 HERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1693
Query: 996 KTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYEL------ 1049
E++ KMQ +M+ + E+ + + +++E ++ + E+ LK LE E+
Sbjct: 1694 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1753
Query: 1050 -----EAKSHLKDDRSRLV-----------------KQMEDKVSQLEMELEEERNNSDLL 1087
A+ + DR + +Q+E ++ QLE ELEEE++NS+LL
Sbjct: 1754 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1813
Query: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
++R + Q+E L EL ER+ E + LERQ ++L+ R+ + R+ +
Sbjct: 1814 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1873
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL---SLTDQKDQL 1204
+ +E+++A+ E++LE E R+R RR E+++KE+V+QV++E L DQ ++
Sbjct: 1874 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1933
Query: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
+LR+K +KRQ+EEAEEE R ++ +++LQRELE+ + E + ++ +++ LR
Sbjct: 1934 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR 1987
Score = 154 bits (389), Expect = 5e-37
Identities = 185/817 (22%), Positives = 352/817 (43%), Gaps = 143/817 (17%)
Query: 584 KIQTLKSRAAGSAQGNNQACNSTSEVKD-LLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 642
+++ ++R A + + C E + L +K +L + V+EL+ ++ E + + ++
Sbjct: 942 QLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT 1001
Query: 643 ERERMRANLEELRS-----------------------------------QHNEKVEENST 667
E++R++ +++EL + Q+++ +E
Sbjct: 1002 EKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL 1061
Query: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQL---SEMHDELDSAKRSEDRE 724
L+ RL E + + E++ + R +++ I D++D+L + EL+ KR D E
Sbjct: 1062 LEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE 1121
Query: 725 KGALIEELLQAKQDLQDL---LIAKEEQ--------ED------LLRKRERELTALKGAL 767
L E++++ +Q ++L L KEE+ ED L K RE A
Sbjct: 1122 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEA 1181
Query: 768 KEEVSSH---DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRV 824
+E++ S + +K + EL+ALR +E+ + A + S+++Q TE++
Sbjct: 1182 QEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN--AQQELRSKREQEVTELK- 1238
Query: 825 KLLQEENEKLQGRSEELERR----VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
K L+EE + +EL +R + +L Q+E + + ++T E E+ +L L
Sbjct: 1239 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1298
Query: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEME 940
+ +E RR LE +L+ QG + + + +EKL+ + E + NE E
Sbjct: 1299 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1358
Query: 941 NERWHLGKTIEKLQKEMADIVE------------ASRTSTLE-----LQNQLDE---YKE 980
++ L K + + ++ D E SR +E L+ QL+E +E
Sbjct: 1359 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE 1418
Query: 981 KNRRELAEMQRQLKE--KTLEAEKSRLTA-----MKMQDEMRLMEEELRDYQRAQDEALT 1033
+ REL Q QL E + E E L A + E + + L + D
Sbjct: 1419 RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLER 1478
Query: 1034 KRQLLEQTLKDLEYELEAKSHL---KDDRSRLVKQM--EDKVSQLEMELEEER-----NN 1083
R+ L+Q L D +LE + L + + R Q+ E+K + L E ER
Sbjct: 1479 GRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE 1538
Query: 1084 SDLLSERISRSREQMEQLRNEL-LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 1142
+ + ++R+ E+ ++ R EL Q RA R +LE +L D+ + LE + R
Sbjct: 1539 REARALSLTRALEEEQEAREELERQNRALRAELE----ALLSSKDDVGKSVHELERACRV 1594
Query: 1143 SKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL---------------ERKVKELV 1187
+++ + A++ ELED L + E + L+++ + L E + ++L
Sbjct: 1595 AEQA-ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA 1653
Query: 1188 MQVDDEHLSLTDQKDQLSLRLKAMKR-----------------QVEEAEEEIDRLESSKK 1230
Q+ D + +++ Q +L + A K+ EEA +++ ++++ K
Sbjct: 1654 KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMK 1713
Query: 1231 KLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVL 1267
+L RE+EE E + Q +K RLK L ++VL
Sbjct: 1714 ELWREVEETRTSREEIFSQNRESEK--RLKGLEAEVL 1748
Score = 134 bits (337), Expect = 6e-31
Identities = 163/691 (23%), Positives = 304/691 (43%), Gaps = 81/691 (11%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
+V++L +Q ++ EV ELQ ++ A LEE R++ E++ +
Sbjct: 921 KVQELQQQSAR---EVGELQGRV------------------AQLEEERARLAEQLRAEAE 959
Query: 668 LQQRLEESEGELRKNLEELFQVKMERE-----------QHQTEIRDLQDQLSEMHDELDS 716
L EE+ G L +EL V E E Q QTE + LQ + E+ L++
Sbjct: 960 LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 1019
Query: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKR---ERELTALKGALKEEVSS 773
+ + + + + + K+ +DLL+ +++ L ++R E L EE
Sbjct: 1020 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE-EE 1078
Query: 774 HDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
+ ++KL+ +Y+A + + + + + K + L + + + + ++ Q+ E+
Sbjct: 1079 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1138
Query: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
L+ + E + + ED G A+ ++L++ + + + +E L R +A
Sbjct: 1139 LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ 1198
Query: 894 RRALENELEAAQGNLSQT---TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
RR L ELEA +G L T T Q++L S++++++ LK +E E +
Sbjct: 1199 RRDLGEELEALRGELEDTLDSTNAQQEL------RSKREQEVTELKKTLEEETRIHEAAV 1252
Query: 951 EKLQKEMADIVEASRTSTLELQNQLDEYKE-KNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
++L++ + EL QL++ + K E + + + L AE S L +
Sbjct: 1253 QELRQRHGQALG-------ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTAR 1305
Query: 1010 MQDEMRLMEEELR---------DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060
+ E R EL+ D +RA+ EA K L++ +LE A + +
Sbjct: 1306 QEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK---LQRAQAELENVSGALNEAESKTI 1362
Query: 1061 RLVKQMEDKVSQLE--MELEEERNNSDL-LSERISRSREQMEQLRNELLQERAARQDLEC 1117
RL K++ +QL EL +E + L L R+ + LR +L +E AAR+
Sbjct: 1363 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1422
Query: 1118 DKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE-LEDRLESEERDRANLQLSN 1176
+ + + Q + + R G+ + +E + AR AE L RL + L+
Sbjct: 1423 ELQTAQAQLSEWRRRQEEEAGALEAGEEAR--RRAAREAEALTQRLAEKTETVDRLERGR 1480
Query: 1177 RRLERKVKELVMQVDDEH--LSLTDQK----DQLSLRLK-AMKRQVEE---AEEEIDRLE 1226
RRL++++ + M ++ + +S ++K DQL K A+ R VEE AE E E
Sbjct: 1481 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1540
Query: 1227 SSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
+ L R LEE+ + E L+ Q +++ +L
Sbjct: 1541 ARALSLTRALEEEQEAREELERQNRALRAEL 1571
Score = 129 bits (323), Expect = 2e-29
Identities = 137/625 (21%), Positives = 276/625 (44%), Gaps = 70/625 (11%)
Query: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE 747
+V R Q ++++LQ Q + EL + E+ L E+L + L E
Sbjct: 910 EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE----LCAEAE 965
Query: 748 EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLA 807
E L R++EL + L+ V E ++ Q E + L++ ++E ++E
Sbjct: 966 ETRGRLAARKQELELVVSELEARVG----EEEECSRQMQTEKKRLQQHIQELEAHLEAEE 1021
Query: 808 SRSNTSEQDQAGTEMRVK-------LLQEENEKLQGRSEELERRVAQLQRQ--------- 851
+ ++ TE ++K LL+++N KL + LE R+A+ Q
Sbjct: 1022 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1081
Query: 852 ---------------IEDLKGDEAKAKETLKK----YEGEIRQLEEALVHARKEEKEAVS 892
+ED E K ++ L+K +GE +L+E +V ++ +E +
Sbjct: 1082 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1141
Query: 893 ARRALENELEAA-------QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945
E EL+AA G +Q + ++ L E E E R + + E +R
Sbjct: 1142 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1201
Query: 946 LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRL 1005
LG+ +E L+ E+ D TL+ N E + K +E+ E+++ L+E+T ++ +
Sbjct: 1202 LGEELEALRGELED--------TLDSTNAQQELRSKREQEVTELKKTLEEET-RIHEAAV 1252
Query: 1006 TAMKMQDEMRLME--EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLV 1063
++ + L E E+L +R + R LE + +L EL + + + +
Sbjct: 1253 QELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR 1312
Query: 1064 KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
+++E ++ +++ + +E++ R++ ++E + L + + L + S E
Sbjct: 1313 RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTE 1372
Query: 1124 RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE--ERDRANLQLSNRRLER 1181
Q D + ++ E + + V MEA A L ++LE E R+RA +L + +
Sbjct: 1373 AQLHDAQ-ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL--QTAQA 1429
Query: 1182 KVKELVMQVDDEHLSL---TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE 1238
++ E + ++E +L + + + + +A+ +++ E E +DRLE +++LQ+EL++
Sbjct: 1430 QLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD 1489
Query: 1239 -QMDMNEHLQGQLNSMKKDLRLKKL 1262
MD+ + Q KK + +L
Sbjct: 1490 ATMDLEQQRQLVSTLEKKQRKFDQL 1514
Score = 123 bits (309), Expect = 1e-27
Identities = 146/645 (22%), Positives = 282/645 (43%), Gaps = 95/645 (14%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKN-QQNIKEE---RERMRANLEELRSQHNE--- 660
+ ++LL+++++ + + R ++ E ++ ++EE RER L+ ++Q +E
Sbjct: 1377 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRR 1436
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRD-LQDQLSEMHDELDSAKR 719
+ EE + + EE+ + E L Q R +TE D L+ + ELD A
Sbjct: 1437 RQEEEAGALEAGEEARRRAAREAEALTQ----RLAEKTETVDRLERGRRRLQQELDDA-- 1490
Query: 720 SEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKG------------AL 767
+ D E+ + L+ KQ D L+A+E+ L ERE +G AL
Sbjct: 1491 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1550
Query: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
+EE + + E+++ AEL+AL S ++ K+V L +EQ A ++R ++
Sbjct: 1551 EEEQEARE-ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQ--AANDLRAQVT 1607
Query: 828 QEENE------------------------KLQGRSEELERRVAQLQRQIED--LKGDEAK 861
+ E+E LQGR E E R QL +Q+ D ++ DE +
Sbjct: 1608 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1667
Query: 862 AKETL-----KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQK 916
+ TL KK EGE+ +L+ + A + ++EAV R ++ +++ + +T ++
Sbjct: 1668 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1727
Query: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQK---EMADIV---EASRTSTLE 970
++ + +E ++ + L ++ E + + Q+ EMAD V S+ + LE
Sbjct: 1728 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1787
Query: 971 LQNQLDEYKEKNRRELAEMQR--------------QLKEKTLEAEKSRLTAMKMQDEMRL 1016
+ QL+ + EL E Q Q++ T E R + K + +
Sbjct: 1788 EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1847
Query: 1017 ME---EELRDYQRAQDEALTKRQ-----LLEQTLKDLEYELEAKSHLKDDRSRLVKQMED 1068
+E +ELR +D R LE L E +LE ++ + +LV++ E
Sbjct: 1848 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1907
Query: 1069 KVSQLEMELEEERNNSDLLSE-------RISRSREQMEQLRNELLQERAARQDLECDKIS 1121
++ ++ +++EEER +D L + R+ + + Q+E+ E + +A R+ L+ +
Sbjct: 1908 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1967
Query: 1122 LERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEE 1166
+ + + + L R + ++ LE+ + S+E
Sbjct: 1968 VTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDE 2012
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 195 bits (496), Expect = 2e-49
Identities = 220/915 (24%), Positives = 402/915 (43%), Gaps = 146/915 (15%)
Query: 466 IDGKVLETEGS-QESTVIRAPSLGAQSKKEEEVKTAT-ATLMLQNRATATSPDSGAKKIS 523
++ +V + EGS ++ +R A+ K E ++K A +T+ ++N K+
Sbjct: 1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFE 1089
Query: 524 VKTFPSA-SNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDAT-KRKVNLV 581
+ S + QA L+ + + Q EE ++I + + R++ +
Sbjct: 1090 ISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEI 1149
Query: 582 FEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQ---LEVKNQQ 638
E+++ AG A N E + QK + +E A LQ + L K+
Sbjct: 1150 SERLEE-----AGGATSAQVELNKKREAEF---QKLRRDLEEATLQHEAMVAALRKKHAD 1201
Query: 639 NIKEERE------RMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNL----EELFQ 688
++ E E R++ LE+ +S+ + ++ S+ + + +++G L K +++ +
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261
Query: 689 VKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEE 748
+K + E+ Q I DL Q + + E R D EK AL+ +L ++KQ A +
Sbjct: 1262 LKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLD-EKDALVSQLSRSKQ-------ASTQ 1313
Query: 749 QEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK-NVEVLA 807
Q + L+ + E T K AL + S + D L+EQY+ E + E +K N EV
Sbjct: 1314 QIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1373
Query: 808 SRSN--------TSEQDQAGTEMRVKLLQEEN--EKLQGRSEELERRVAQLQRQIEDLKG 857
R+ T E ++A ++ +L + E E + + LE+ +LQ ++EDL
Sbjct: 1374 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433
Query: 858 DEAKAK------------------ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE- 898
D ++ E +KYE +LE + +R E + E
Sbjct: 1434 DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEE 1493
Query: 899 --NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956
++LE + QE L+E++ E +Q +L ++K ++E E+ + +E+ +
Sbjct: 1494 SLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEAS 1553
Query: 957 MADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE-------------KTLEAE-K 1002
+ E L +Q +L++ K + R++AE ++ + TL+AE +
Sbjct: 1554 L----EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIR 1609
Query: 1003 SRLTAMKMQDEM---------------RLMEEELRDYQRAQ----------DEALTKRQ- 1036
SR A++++ +M RL E LR+Y+ Q D+AL ++
Sbjct: 1610 SRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQED 1669
Query: 1037 -------------LLEQTLKDLEYELE--------AKSHLKDDRSRLV------------ 1063
LL+ +++L LE A+ L D R+
Sbjct: 1670 LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1729
Query: 1064 -KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISL 1122
K++E+ VSQL+ E+EE S E+ ++ + EL +E+ LE K +L
Sbjct: 1730 KKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1789
Query: 1123 ERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERK 1182
E+ KDL+ R+ E + + ++EAR+ ELE +E+E++ A R+ ER+
Sbjct: 1790 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERR 1849
Query: 1183 VKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
VKEL Q +++ L L D D+L ++K+ KRQ EEAEE+ + S +KLQ ELEE
Sbjct: 1850 VKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEA 1909
Query: 1240 MDMNEHLQGQLNSMK 1254
+ + + Q+N ++
Sbjct: 1910 EERADIAESQVNKLR 1924
Score = 157 bits (396), Expect = 8e-38
Identities = 159/726 (21%), Positives = 335/726 (46%), Gaps = 96/726 (13%)
Query: 563 LKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIE 622
LK T+ + AT + E+ Q K A S ++ K+L E+ L E
Sbjct: 843 LKSAETEKEMATMK------EEFQKTKDELA----------KSEAKRKELEEKMVTLLKE 886
Query: 623 VAELQRQLQLEVKNQQNIKEERERM-------RANLEELRSQHNEKVEENSTL---QQRL 672
+LQ Q+Q E + + +E E++ A ++E+ + E+ E N+ L +++L
Sbjct: 887 KNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKL 946
Query: 673 EESEGELRKNLE--ELFQVKMEREQHQTE--IRDLQDQLSEMHDELDSAKRSEDREKGAL 728
E+ EL+K+++ EL K+E+E+H TE +++L ++++ + + + AK S +EK AL
Sbjct: 947 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI--AKLS--KEKKAL 1002
Query: 729 IEELLQAKQDLQDLLIAKEEQEDLLRKR----ERELTALKGALKEEVSSHDQEMDKLKEQ 784
E Q DLQ A+E++ ++L K E+++ L+G+L++E ++++ K +
Sbjct: 1003 QETHQQTLDDLQ----AEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLR-MDLERAKRK 1057
Query: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERR 844
+ +L+ +ES + + + L + E + + +++ Q +LQ + +EL+ R
Sbjct: 1058 LEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQAR 1117
Query: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
+ +L +IE + AKA++ E+ ++ E L A V + E E +
Sbjct: 1118 IEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKL 1177
Query: 905 QGNLSQTTQE--------QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956
+ +L + T + +K+ ++ + E EQ + L+R+K ++E E+ L + L
Sbjct: 1178 RRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSN 1237
Query: 957 MADIVEAS---RTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE 1013
I +A L++Q+ E K K E QR + + L A+++RL Q E
Sbjct: 1238 AEAISKAKGNLEKMCRSLEDQVSELKTKEE----EQQRLIND--LTAQRARL-----QTE 1286
Query: 1014 MRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL 1073
+L + + +Q Q +++L+++LE ++ K+ + ++ L
Sbjct: 1287 AGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLL 1346
Query: 1074 EMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRI 1133
+ EEE+ L +S++ ++ Q R + E D I + ++ K ++
Sbjct: 1347 REQYEEEQEGKAELQRALSKANSEVAQWRTK----------YETDAIQRTEELEEAKKKL 1396
Query: 1134 IHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDE 1193
R+ E E+ +E+ A+L+ + +RL+ +V++L++ V+
Sbjct: 1397 AQ------------------RLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERS 1438
Query: 1194 H---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQL 1250
+ +L ++ L K++ EE + E++ + + L EL + ++ E QL
Sbjct: 1439 NAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 1251 NSMKKD 1256
+++++
Sbjct: 1499 ETLRRE 1504
Score = 147 bits (372), Expect = 5e-35
Identities = 142/711 (19%), Positives = 319/711 (44%), Gaps = 83/711 (11%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
+V L + K+KL +V +L+ L+ E K + +++ + ++ +L+ + + +
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078
Query: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE---DRE 724
L ++LE+ E E+ + ++ + Q Q +I++LQ ++ E+ +E+++ + S +++
Sbjct: 1079 LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138
Query: 725 KGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784
+ L EL + + L++ A Q +L +KRE E L+ L+E H+ + L+++
Sbjct: 1139 RSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK 1198
Query: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERR 844
+ + L E ++ + + L E++++ +M L E + LE+
Sbjct: 1199 HADSMAELGEQIDNLQRVKQKL-------EKEKSELKMETDDLSSNAEAISKAKGNLEKM 1251
Query: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE-EALVHARK-EEKEAV-----SARRAL 897
L+ Q+ +LK E + + + + +L+ EA ++R+ +EK+A+ +++A
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 898 ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEM 957
++E + L + T+ + L+ L+ + LR E + + L + + K E+
Sbjct: 1312 TQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1371
Query: 958 ADIVEASRTSTLELQNQLDEYKEKNRRELAE---------------------MQRQLKEK 996
A T ++ +L+E K+K + L E +Q ++++
Sbjct: 1372 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1431
Query: 997 TLEAEKSRLTAMKM----------------------------QDEMRLMEEELRDYQRAQ 1028
L+ E+S + Q E R + EL +
Sbjct: 1432 MLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVY 1491
Query: 1029 DEALTKRQL-------LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER 1081
+E+L + + L+Q + DL ++ + ++ KQ+E + +++ LEE
Sbjct: 1492 EESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAE 1551
Query: 1082 NNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYR 1141
+ + +I R + ++ Q+++E + + A +D E D++ + +++ L+ R
Sbjct: 1552 ASLEHEEGKILRIQLELNQVKSE-VDRKIAEKDEEIDQLK-RNHTRVVETMQSTLDAEIR 1609
Query: 1142 SSKEGLVV--QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
S + L V +ME + E+E +L R A + R + +KE + +DD D
Sbjct: 1610 SRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQED 1669
Query: 1200 QKDQLSL---RLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQ 1247
K+QL++ R ++ ++EE +++ E S+K ++EL +D +E +Q
Sbjct: 1670 LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL---LDASERVQ 1717
Score = 125 bits (313), Expect = 3e-28
Identities = 138/660 (20%), Positives = 292/660 (44%), Gaps = 66/660 (10%)
Query: 467 DGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATS-----PDSGAKK 521
D V + S++++ + L Q ++E + K A A + +R + K
Sbjct: 1298 DALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1357
Query: 522 ISVKTFPSASNTQATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNL 580
++ S +N++ K + + Q+T E E AK+ L L+E ++ +A K
Sbjct: 1358 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE-EHVEAVNAKCAS 1416
Query: 581 VFEKIQTLKSRAAG---SAQGNNQACNSTSEV-----KDLLEQKSKLTIEVAELQRQLQL 632
+ + Q L++ + +N AC + + K L E K K E Q +L+
Sbjct: 1417 LEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE----ETQAELEA 1472
Query: 633 EVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQR---LEESEGELRKNLEELFQV 689
K +++ E +++ EE Q EN LQQ L E E K + EL ++
Sbjct: 1473 SQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKI 1532
Query: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE---ELLQAKQDLQDLLIAK 746
K + EQ + EI+ L+ A+ S + E+G ++ EL Q K ++ + K
Sbjct: 1533 KKQVEQEKCEIQAA----------LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEK 1582
Query: 747 EEQEDLLRKRE-RELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEV 805
+E+ D L++ R + ++ L E+ S + + ++K++ + +L + + A +
Sbjct: 1583 DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDAL-RVKKKMEGDLNEMEIQLNHANR---- 1637
Query: 806 LASRSNTSEQDQAG----TEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAK 861
LA+ S + ++ G T++ + E L+ + +ERR LQ +IE+L +
Sbjct: 1638 LAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQ 1697
Query: 862 AKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEK 921
+ + K E E+ E + + ++ ++ LEN++ Q + + QE + EK
Sbjct: 1698 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEK 1757
Query: 922 LK----EESEQKEQLRRLKN---EMENERWHLGKTIEKLQKEMADI-----------VEA 963
K + + E+L++ ++ +E + +L +T++ LQ + + ++
Sbjct: 1758 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1817
Query: 964 SRTSTLELQNQLDEYKEKNR---RELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE 1020
EL+ +++ +++N + L + +R++KE T + E+ R +++QD + ++ +
Sbjct: 1818 LEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAK 1877
Query: 1021 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
++ Y+R +EA + + L++ELE D V ++ K ++ ++ E
Sbjct: 1878 VKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 103 bits (258), Expect = 8e-22
Identities = 94/449 (20%), Positives = 207/449 (46%), Gaps = 58/449 (12%)
Query: 846 AQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQ 905
A+ ++++ +K + K K+ L K E + ++LEE +V KE+ + ++ + L A+
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 906 GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965
Q + + QL K+KE +E+ E+ + E+ ++ L +L+K++ D+
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL--ELT 963
Query: 966 TSTLELQNQLDEYKEKN-RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDY 1024
+ +E + E K KN E+A + + + + E + + T + D+++ E+++
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNIL 1023
Query: 1025 QRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNS 1084
+A+ + LEQ + DLE LE + L+ D R +++E + + + N+
Sbjct: 1024 TKAKTK-------LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDK 1076
Query: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSK 1144
L E++ + ++ L +++ E+A +I L+++ K+L
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAV-------EIQLQKKIKEL--------------- 1114
Query: 1145 EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKD-- 1202
+ARI EL + +E+E RA + L R+++E+ ++++ + + Q +
Sbjct: 1115 -------QARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELN 1167
Query: 1203 -QLSLRLKAMKRQVEEA----EEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
+ + ++R +EEA E + L EL EQ+D + ++ +L K +L
Sbjct: 1168 KKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSEL 1227
Query: 1258 RLKKLPSKVLDDMDDDDDLSTDGGSLYEA 1286
++ + DDLS++ ++ +A
Sbjct: 1228 KM------------ETDDLSSNAEAISKA 1244
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 192 bits (488), Expect = 2e-48
Identities = 218/929 (23%), Positives = 407/929 (43%), Gaps = 146/929 (15%)
Query: 466 IDGKVLETEGS-QESTVIRAPSLGAQSKKEEEVKTATATLM-LQNRATATSPDSGAKKIS 523
++ +V + EGS ++ +R A+ K E ++K A ++M ++N K+
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092
Query: 524 VKTFPSA-SNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDAT-KRKVNLV 581
+ S + QA L+ + + Q EE ++I + + R++ +
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 582 FEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ------------KSKLTIEVAELQRQ 629
E+++ + + N + +++ LE+ + K VAEL Q
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212
Query: 630 LQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQV 689
+ + +Q +++E+ M+ +++L S VE S + LE+ L L EL
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASN----VETVSKAKGNLEKMCRTLEDQLSEL--- 1265
Query: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749
K + E+ Q I DL Q + E R D EK AL+ +L + KQ ++
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD-EKEALVSQLSRGKQAFT------QQI 1318
Query: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK-NVEVLAS 808
E+L R+ E E+ A K AL + S + D L+EQY+ E ++ E +K N EV
Sbjct: 1319 EELKRQLEEEIKA-KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 809 RSN--------TSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 858
R+ T E ++A ++ R++ +E E + + LE+ +LQ ++EDL D
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 859 EAKAK------------------ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE-- 898
+ E +K E +LE + AR E + A E
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEES 1497
Query: 899 -NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEM 957
++LE + QE L+E++ E ++ +L ++K ++E E+ L +E+ + +
Sbjct: 1498 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL 1557
Query: 958 ADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE-------------KTLEAE-KS 1003
E L +Q +L++ K + R++AE ++ + TL+AE +S
Sbjct: 1558 ----EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613
Query: 1004 RLTAMKMQDEM---------------RLMEEELRDYQRAQ----------DEALTKRQ-- 1036
R A++++ +M R+ E LR+Y+ Q D+AL ++
Sbjct: 1614 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673
Query: 1037 ------------LLEQTLKDLEYELE--------AKSHLKDDRSRLV------------- 1063
LL+ +++L LE A+ L D R+
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1733
Query: 1064 KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
K++E +SQ++ E+E+ + E+ ++ + EL +E+ LE K ++E
Sbjct: 1734 KKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1793
Query: 1124 RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKV 1183
+ KDL+ R+ E + + ++EAR+ ELE +ESE++ A R+ ER+V
Sbjct: 1794 QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRV 1853
Query: 1184 KELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQM 1240
KEL Q +++ L L D D+L ++K+ KRQ EEAEE+ + + +KLQ ELEE
Sbjct: 1854 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAE 1913
Query: 1241 DMNEHLQGQLNSMKKDLRLKKLPSKVLDD 1269
+ + + Q+N ++ ++ +++ +KV+ +
Sbjct: 1914 ERADIAESQVNKLR--VKSREVHTKVISE 1940
Score = 156 bits (394), Expect = 1e-37
Identities = 172/752 (22%), Positives = 340/752 (45%), Gaps = 107/752 (14%)
Query: 563 LKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIE 622
LK T+ + AT + E+ Q +K A S ++ K+L E+ L E
Sbjct: 846 LKSAETEKEMATMK------EEFQKIKDELA----------KSEAKRKELEEKMVTLLKE 889
Query: 623 VAELQRQLQLEVKNQQNIKEE-------RERMRANLEELRSQHNEKVEENSTL---QQRL 672
+LQ Q+Q E + + +E + ++ A ++E+ + ++ E N+ L +++L
Sbjct: 890 KNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL 949
Query: 673 EESEGELRKNLE--ELFQVKMEREQHQTE--IRDLQDQLSEMHDELDSAKRSEDREKGAL 728
E+ EL+K+++ EL K+E+E+H TE +++L ++++ LD +EK AL
Sbjct: 950 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDETIAKLTKEKKAL 1005
Query: 729 IEELLQAKQDLQDLLIAKEEQEDLLRKR----ERELTALKGALKEEVSSHDQEMDKLKEQ 784
E Q DLQ A+E++ + L K E+++ L+G+L++E ++++ K +
Sbjct: 1006 QEAHQQTLDDLQ----AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR-MDLERAKRK 1060
Query: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERR 844
+ +L+ +ES+ + + L + E + + + +++ Q +LQ + +EL+ R
Sbjct: 1061 LEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
+ +L+ +IE + AKA++ E+ ++ E L A + + E E +
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 905 QGNLSQTTQE--------QKQLSEKLKEESEQKEQLRRLKNEMENERWH-------LGKT 949
+ +L + T + +K+ ++ + E EQ + L+R+K ++E E+ L
Sbjct: 1181 RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
+E + K ++ + RT L++QL E K K E QR + + L A++ RL
Sbjct: 1241 VETVSKAKGNLEKMCRT----LEDQLSELKSKEE----EQQRLIND--LTAQRGRL---- 1286
Query: 1010 MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDK 1069
Q E +L + + + +Q Q +++L+ +LE + K+ + ++
Sbjct: 1287 -QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 1070 VSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL 1129
L + EEE+ + L +S++ ++ Q R + + R + LE K L
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE------ELEEAKKKL 1399
Query: 1130 KSRIIHLEGSYRSSKEGLVVQMEARIAELE---DRLESEERDR-----------ANLQLS 1175
R+ + E V + A+ A LE RL++E D A L
Sbjct: 1400 AQRL--------QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Query: 1176 NRRLERKVKELVMQVDDEHLSL-TDQKDQLSL--RLKAMKRQVEEAEEEIDRLESSKKKL 1232
R ++ + E + ++ H L QK+ SL L +K EE+ ++++ L+ K L
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL 1511
Query: 1233 QRE---LEEQMDMNEHLQGQLNSMKKDLRLKK 1261
Q+E L EQ+ +L +KK + +K
Sbjct: 1512 QQEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543
Score = 152 bits (384), Expect = 2e-36
Identities = 157/695 (22%), Positives = 326/695 (46%), Gaps = 82/695 (11%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE-E 674
K K ++ AE ++++ + Q IK+E + A +EL + ++E + LQ +++ E
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAE 900
Query: 675 SEG--ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
+EG + + ++L + K++ E E+ + + E++ EL + KR L +E
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-------LEDEC 953
Query: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAEL 789
+ K+D+ DL E L K E+E A + +K EE++ D+ + KL + E
Sbjct: 954 SELKKDIDDL-------ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK----EK 1002
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL- 848
+AL+E+ ++ +++ + NT + + E +V L+ E+ + +LER +L
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 849 ------QRQIEDLKGDEAKAKETLKKYEGEIRQL------EEAL-VHARKEEKEAVSARR 895
Q I D++ ++ + E LKK E EI L E+AL + +K+ KE +
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ------------------LRRLKN 937
LE E+EA + + ++ +++ LS +L+E SE+ E+ ++++
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 938 EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEY---KEKNRRELAEMQRQLK 994
++E T L+K+ AD S EL Q+D K+K +E +EM+ ++
Sbjct: 1183 DLEEATLQHEATAATLRKKHAD-------SVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 995 E-----KTLEAEKSRLTAM--KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEY 1047
+ +T+ K L M ++D++ ++ + + QR ++ +R L+ +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQ 1107
+L+ K L SR + ++ +L+ +LEEE + L+ + SR + LR + +
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEE 1355
Query: 1108 ERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL---VVQMEARIAELEDRLES 1164
E+ ++ +L+ +L + N ++ E E L ++ R+ E+ +E+
Sbjct: 1356 EQESKAELQ---RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA 1412
Query: 1165 EERDRANLQLSNRRLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEE 1221
A+L+ + +RL+ +V++L++ V+ + +L ++ L K++ EE E
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1472
Query: 1222 IDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKD 1256
++ + + L EL + + E QL ++K++
Sbjct: 1473 LEASQKEARSLGTELFKIKNAYEESLDQLETLKRE 1507
Score = 69.7 bits (169), Expect = 2e-11
Identities = 48/208 (23%), Positives = 104/208 (50%), Gaps = 24/208 (11%)
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLV 1148
+ ++ +E+ +++++EL + A R++LE ++L ++ DL+ ++ ++ EGL
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV-------QAEAEGLA 905
Query: 1149 -------------VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195
+Q+EA+I E+ +R E EE A L R+LE + EL +DD L
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 1196 SLT---DQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
+L +K ++K + ++ +E I +L KK LQ ++ +D + + ++N+
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 1253 M-KKDLRLKKLPSKVLDDMDDDDDLSTD 1279
+ K ++L++ + ++ + L D
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMD 1053
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 192 bits (488), Expect = 2e-48
Identities = 218/929 (23%), Positives = 407/929 (43%), Gaps = 146/929 (15%)
Query: 466 IDGKVLETEGS-QESTVIRAPSLGAQSKKEEEVKTATATLM-LQNRATATSPDSGAKKIS 523
++ +V + EGS ++ +R A+ K E ++K A ++M ++N K+
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092
Query: 524 VKTFPSA-SNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDAT-KRKVNLV 581
+ S + QA L+ + + Q EE ++I + + R++ +
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 582 FEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ------------KSKLTIEVAELQRQ 629
E+++ + + N + +++ LE+ + K VAEL Q
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212
Query: 630 LQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQV 689
+ + +Q +++E+ M+ +++L S VE S + LE+ L L EL
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASN----VETVSKAKGNLEKMCRTLEDQLSEL--- 1265
Query: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749
K + E+ Q I DL Q + E R D EK AL+ +L + KQ ++
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD-EKEALVSQLSRGKQAFT------QQI 1318
Query: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK-NVEVLAS 808
E+L R+ E E+ A K AL + S + D L+EQY+ E ++ E +K N EV
Sbjct: 1319 EELKRQLEEEIKA-KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 809 RSN--------TSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 858
R+ T E ++A ++ R++ +E E + + LE+ +LQ ++EDL D
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 859 EAKAK------------------ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE-- 898
+ E +K E +LE + AR E + A E
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEES 1497
Query: 899 -NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEM 957
++LE + QE L+E++ E ++ +L ++K ++E E+ L +E+ + +
Sbjct: 1498 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL 1557
Query: 958 ADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE-------------KTLEAE-KS 1003
E L +Q +L++ K + R++AE ++ + TL+AE +S
Sbjct: 1558 ----EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613
Query: 1004 RLTAMKMQDEM---------------RLMEEELRDYQRAQ----------DEALTKRQ-- 1036
R A++++ +M R+ E LR+Y+ Q D+AL ++
Sbjct: 1614 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673
Query: 1037 ------------LLEQTLKDLEYELE--------AKSHLKDDRSRLV------------- 1063
LL+ +++L LE A+ L D R+
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1733
Query: 1064 KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
K++E +SQ++ E+E+ + E+ ++ + EL +E+ LE K ++E
Sbjct: 1734 KKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1793
Query: 1124 RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKV 1183
+ KDL+ R+ E + + ++EAR+ ELE +ESE++ A R+ ER+V
Sbjct: 1794 QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRV 1853
Query: 1184 KELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQM 1240
KEL Q +++ L L D D+L ++K+ KRQ EEAEE+ + + +KLQ ELEE
Sbjct: 1854 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAE 1913
Query: 1241 DMNEHLQGQLNSMKKDLRLKKLPSKVLDD 1269
+ + + Q+N ++ ++ +++ +KV+ +
Sbjct: 1914 ERADIAESQVNKLR--VKSREVHTKVISE 1940
Score = 156 bits (394), Expect = 1e-37
Identities = 172/752 (22%), Positives = 340/752 (45%), Gaps = 107/752 (14%)
Query: 563 LKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIE 622
LK T+ + AT + E+ Q +K A S ++ K+L E+ L E
Sbjct: 846 LKSAETEKEMATMK------EEFQKIKDELA----------KSEAKRKELEEKMVTLLKE 889
Query: 623 VAELQRQLQLEVKNQQNIKEE-------RERMRANLEELRSQHNEKVEENSTL---QQRL 672
+LQ Q+Q E + + +E + ++ A ++E+ + ++ E N+ L +++L
Sbjct: 890 KNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL 949
Query: 673 EESEGELRKNLE--ELFQVKMEREQHQTE--IRDLQDQLSEMHDELDSAKRSEDREKGAL 728
E+ EL+K+++ EL K+E+E+H TE +++L ++++ LD +EK AL
Sbjct: 950 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDETIAKLTKEKKAL 1005
Query: 729 IEELLQAKQDLQDLLIAKEEQEDLLRKR----ERELTALKGALKEEVSSHDQEMDKLKEQ 784
E Q DLQ A+E++ + L K E+++ L+G+L++E ++++ K +
Sbjct: 1006 QEAHQQTLDDLQ----AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR-MDLERAKRK 1060
Query: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERR 844
+ +L+ +ES+ + + L + E + + + +++ Q +LQ + +EL+ R
Sbjct: 1061 LEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
+ +L+ +IE + AKA++ E+ ++ E L A + + E E +
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 905 QGNLSQTTQE--------QKQLSEKLKEESEQKEQLRRLKNEMENERWH-------LGKT 949
+ +L + T + +K+ ++ + E EQ + L+R+K ++E E+ L
Sbjct: 1181 RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
+E + K ++ + RT L++QL E K K E QR + + L A++ RL
Sbjct: 1241 VETVSKAKGNLEKMCRT----LEDQLSELKSKEE----EQQRLIND--LTAQRGRL---- 1286
Query: 1010 MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDK 1069
Q E +L + + + +Q Q +++L+ +LE + K+ + ++
Sbjct: 1287 -QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 1070 VSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL 1129
L + EEE+ + L +S++ ++ Q R + + R + LE K L
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE------ELEEAKKKL 1399
Query: 1130 KSRIIHLEGSYRSSKEGLVVQMEARIAELE---DRLESEERDR-----------ANLQLS 1175
R+ + E V + A+ A LE RL++E D A L
Sbjct: 1400 AQRL--------QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Query: 1176 NRRLERKVKELVMQVDDEHLSL-TDQKDQLSL--RLKAMKRQVEEAEEEIDRLESSKKKL 1232
R ++ + E + ++ H L QK+ SL L +K EE+ ++++ L+ K L
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL 1511
Query: 1233 QRE---LEEQMDMNEHLQGQLNSMKKDLRLKK 1261
Q+E L EQ+ +L +KK + +K
Sbjct: 1512 QQEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543
Score = 152 bits (384), Expect = 2e-36
Identities = 157/695 (22%), Positives = 326/695 (46%), Gaps = 82/695 (11%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE-E 674
K K ++ AE ++++ + Q IK+E + A +EL + ++E + LQ +++ E
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAE 900
Query: 675 SEG--ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
+EG + + ++L + K++ E E+ + + E++ EL + KR L +E
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-------LEDEC 953
Query: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAEL 789
+ K+D+ DL E L K E+E A + +K EE++ D+ + KL + E
Sbjct: 954 SELKKDIDDL-------ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK----EK 1002
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL- 848
+AL+E+ ++ +++ + NT + + E +V L+ E+ + +LER +L
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 849 ------QRQIEDLKGDEAKAKETLKKYEGEIRQL------EEAL-VHARKEEKEAVSARR 895
Q I D++ ++ + E LKK E EI L E+AL + +K+ KE +
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ------------------LRRLKN 937
LE E+EA + + ++ +++ LS +L+E SE+ E+ ++++
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 938 EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEY---KEKNRRELAEMQRQLK 994
++E T L+K+ AD S EL Q+D K+K +E +EM+ ++
Sbjct: 1183 DLEEATLQHEATAATLRKKHAD-------SVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 995 E-----KTLEAEKSRLTAM--KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEY 1047
+ +T+ K L M ++D++ ++ + + QR ++ +R L+ +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQ 1107
+L+ K L SR + ++ +L+ +LEEE + L+ + SR + LR + +
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEE 1355
Query: 1108 ERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL---VVQMEARIAELEDRLES 1164
E+ ++ +L+ +L + N ++ E E L ++ R+ E+ +E+
Sbjct: 1356 EQESKAELQ---RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA 1412
Query: 1165 EERDRANLQLSNRRLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEE 1221
A+L+ + +RL+ +V++L++ V+ + +L ++ L K++ EE E
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1472
Query: 1222 IDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKD 1256
++ + + L EL + + E QL ++K++
Sbjct: 1473 LEASQKEARSLGTELFKIKNAYEESLDQLETLKRE 1507
Score = 69.7 bits (169), Expect = 2e-11
Identities = 48/208 (23%), Positives = 104/208 (50%), Gaps = 24/208 (11%)
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLV 1148
+ ++ +E+ +++++EL + A R++LE ++L ++ DL+ ++ ++ EGL
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV-------QAEAEGLA 905
Query: 1149 -------------VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195
+Q+EA+I E+ +R E EE A L R+LE + EL +DD L
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 1196 SLT---DQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
+L +K ++K + ++ +E I +L KK LQ ++ +D + + ++N+
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 1253 M-KKDLRLKKLPSKVLDDMDDDDDLSTD 1279
+ K ++L++ + ++ + L D
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMD 1053
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 191 bits (486), Expect = 3e-48
Identities = 201/859 (23%), Positives = 371/859 (43%), Gaps = 142/859 (16%)
Query: 534 QATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAA 593
Q L K + ++ QQ ++ +Q+L L++ +N + ++ + E+++ ++ A
Sbjct: 1077 QLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKEN----QARIEELEEELEAERTARA 1132
Query: 594 GSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEV-KNQQNIKEERERMRANLE 652
+ + E+ + LE+ T E+ ++ + E K +++++E + A
Sbjct: 1133 KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 653 ELRSQH-------NEKVEENSTLQQRLEESEGELR-------KNLEELFQVKMEREQHQT 698
LR +H E+++ ++Q+LE+ + E + N+E++ + K E+
Sbjct: 1193 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVS- 1251
Query: 699 EIRDLQDQLSEMHDELDSAKRSED----------REKGALIEELLQAKQDLQDLLIAK-- 746
R L+DQ +E +L+ A+RS + E G L +L + + + L K
Sbjct: 1252 --RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLS 1309
Query: 747 --EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK-NV 803
++ EDL R+ E E A K AL + S + D L+EQY+ E +A E +K N
Sbjct: 1310 YTQQMEDLKRQLEEEGKA-KNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1368
Query: 804 EVLASRSN--------TSEQDQAGTEMRVKLLQEEN--EKLQGRSEELERRVAQLQRQIE 853
EV R+ T E ++A ++ +L E E + + LE+ +LQ +IE
Sbjct: 1369 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE 1428
Query: 854 DLKGDEAKAK------------------ETLKKYEGEIRQLEEALVHARKEEKEAVSARR 895
DL D ++ E +KYE +LE + AR E +
Sbjct: 1429 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1488
Query: 896 ALENELEAAQGNLSQTTQEQKQLS---EKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 952
A E LE + + Q+++S E+L E + +L +++ ++E E+ L +E+
Sbjct: 1489 AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEE 1548
Query: 953 ----LQKEMADIVEAS----------RTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTL 998
L+ E I+ A E ++++ K ++R + +Q L +T
Sbjct: 1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETR 1608
Query: 999 EAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELE----AKSH 1054
+ KM+ ++ ME +L R EA + + L+ LKD + +L+ A
Sbjct: 1609 SRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1668
Query: 1055 LKD--------------------------DRSRLV------------------------- 1063
LK+ +RSR +
Sbjct: 1669 LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1728
Query: 1064 -KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISL 1122
K+ME ++QL+ E+EE E+ ++ + EL +E+ LE K ++
Sbjct: 1729 KKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1788
Query: 1123 ERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERK 1182
E+ KDL+ R+ E + + ++EAR+ ELE LE+E++ A R+ ER+
Sbjct: 1789 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERR 1848
Query: 1183 VKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
+KEL Q +++ L L D D+L L++KA KRQ EEAEE+ + S +K+Q EL+E
Sbjct: 1849 IKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1908
Query: 1240 MDMNEHLQGQLNSMKKDLR 1258
+ + + Q+N ++ R
Sbjct: 1909 EERADIAESQVNKLRAKSR 1927
Score = 149 bits (375), Expect = 2e-35
Identities = 152/690 (22%), Positives = 318/690 (46%), Gaps = 49/690 (7%)
Query: 605 STSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRAN---LEELRSQHNEK 661
S + K+L E+ L E +LQ Q+Q E N + +E +++ N LE + NE+
Sbjct: 868 SEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNER 927
Query: 662 VEENSTL-------QQRLEESEGELRKNLE--ELFQVKMEREQHQTE--IRDLQDQLSEM 710
+E+ + +++LE+ EL+K+++ EL K+E+E+H TE +++L ++++
Sbjct: 928 LEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA-- 985
Query: 711 HDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLR---KRERELTALKGAL 767
LD +EK AL E QA DLQ + +++ L + K E+++ L+G+L
Sbjct: 986 --GLDEIIAKLTKEKKALQEAHQQALDDLQ---VEEDKVNSLSKSKVKLEQQVDDLEGSL 1040
Query: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
++E ++++ K + + +L+ +ES+ + + L + E D +++
Sbjct: 1041 EQEKKVR-MDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDE 1099
Query: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEE 887
Q +LQ + +E + R+ +L+ ++E + AK ++ E+ ++ E L A
Sbjct: 1100 QVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT 1159
Query: 888 KEAVSARRALENELEAAQGNLSQTTQE--------QKQLSEKLKEESEQKEQLRRLKNEM 939
+ + E E + + +L + T + +K+ ++ + E EQ + L+R+K ++
Sbjct: 1160 SVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219
Query: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
E E+ ++ + M I++A + + ++ L++ + R +L E QR L + T +
Sbjct: 1220 EKEKSEFKLELDDVTSNMEQIIKA-KANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ 1278
Query: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
K+Q E + +L + + + + Q ++DL+ +LE + K+
Sbjct: 1279 -------RAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNAL 1331
Query: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAAR-QDLECD 1118
+ ++ L + EEE L +S++ ++ Q R + + R ++LE
Sbjct: 1332 AHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA 1391
Query: 1119 KISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRR 1178
K L ++ +D + + + SS E +++ I +L +E A L R
Sbjct: 1392 KKKLAQRLQDAEEAVEAVNAKC-SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN 1450
Query: 1179 LERKVKELVMQVDDEHLSL-TDQKD--QLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRE 1235
++ + E + ++ L + QK+ LS L +K EE+ E ++ + K LQ E
Sbjct: 1451 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEE 1510
Query: 1236 ---LEEQMDMNEHLQGQLNSMKKDLRLKKL 1262
L EQ+ +L ++K L ++KL
Sbjct: 1511 ISDLTEQLGEGGKNVHELEKVRKQLEVEKL 1540
Score = 145 bits (366), Expect = 2e-34
Identities = 150/647 (23%), Positives = 304/647 (46%), Gaps = 74/647 (11%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
K K ++ AE ++++ + IKE E+ A +EL + ++E + LQ +++
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 896
Query: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLS---EMHDELDSAKRSEDREKGALIEEL 732
+ L E Q+ + Q + +++++ ++L EM+ EL + KR L +E
Sbjct: 897 QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK-------LEDEC 949
Query: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAEL 789
+ K+D+ DL E L K E+E A + +K EE++ D+ + KL + E
Sbjct: 950 SELKKDIDDL-------ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK----EK 998
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQ-- 847
+AL+E+ ++A +++V E+D +V L + KL+ + ++LE + Q
Sbjct: 999 KALQEAHQQALDDLQV--------EED------KVNSLSKSKVKLEQQVDDLEGSLEQEK 1044
Query: 848 -----LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELE 902
L+R L+GD +E++ E + QLEE L +K+E + +E+E
Sbjct: 1045 KVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKL---KKKEFDINQQNSKIEDEQV 1101
Query: 903 AA---QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
A Q L + ++L E+L+ E + ++ +L++++ E + + +E
Sbjct: 1102 LALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE-------- 1153
Query: 960 IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ-DEMRLME 1018
EA +++++ E +K E +M+R L+E TL+ E + K D + +
Sbjct: 1154 --EAGGATSVQI-----EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG 1206
Query: 1019 EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELE 1078
E++ + QR + + ++ + L D+ +E K + ++ + +ED+ ++ ++LE
Sbjct: 1207 EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLE 1266
Query: 1079 E-ERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLE 1137
E +R+ +D ++R E E L +L ++ A L K+S +Q +DLK R + E
Sbjct: 1267 EAQRSLNDFTTQRAKLQTENGE-LARQLEEKEALISQLTRGKLSYTQQMEDLK-RQLEEE 1324
Query: 1138 GSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSL 1197
G +++ + L ++ E E +A LQ + +V + + + + +
Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1384
Query: 1198 TDQ----KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQM 1240
T++ K +L+ RL+ + VE + LE +K +LQ E+E+ M
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431
Score = 108 bits (269), Expect = 4e-23
Identities = 105/478 (21%), Positives = 232/478 (48%), Gaps = 65/478 (13%)
Query: 846 AQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQ 905
A+ ++++ +K + + KETL+K E ++LEE +V +E+ + +A ++ L A+
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 906 GNLSQTTQEQ-------KQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
Q + + K+++E+L++E E +L K ++E+E L K I+ L+ +A
Sbjct: 905 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLA 964
Query: 959 DIVEASRTSTLELQNQLDEYK---------EKNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
+ + + +++N +E K ++ L E +Q + L+ E+ ++ ++
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD-DLQVEEDKVNSLS 1023
Query: 1010 MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYEL----EAKSHLKDDRSRL--- 1062
+ +++L E+++ D + + ++ R LE+ + LE +L E+ L++D+ +L
Sbjct: 1024 -KSKVKL-EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK 1081
Query: 1063 VKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISL 1122
+K+ E ++Q ++E+E+ + L +++ ++ ++E+L EL ER AR +E + L
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 1123 ERQNKDLKSRIIHLEGS-----------------YRSSKEGLVVQMEARIAELE----DR 1161
R+ +++ R+ G+ R E +Q EA A L D
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201
Query: 1162 LESEERDRANLQLSNRRLERKVKELVMQVDD---------------EHLS--LTDQKDQL 1204
+ NLQ ++LE++ E +++DD E +S L DQ ++
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEY 1261
Query: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHL-QGQLNSMKKDLRLKK 1261
++L+ +R + + + +L++ +L R+LEE+ + L +G+L+ ++ LK+
Sbjct: 1262 RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKR 1319
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 191 bits (485), Expect = 4e-48
Identities = 201/875 (22%), Positives = 378/875 (43%), Gaps = 167/875 (19%)
Query: 548 QQTNEETAKQILYNYLKEGSTDNDDAT-----------KRKVNLVFEKIQTLKSRAAGSA 596
QQ NE+ K+ +G +++ A + ++ + E+I+ ++ A +
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 597 QGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEV-KNQQNIKEERERMRANLEELR 655
+ + E+ + LE+ T E+ ++ + E K +++++E + A LR
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALR 1197
Query: 656 SQH-------NEKVEENSTLQQRLEESEGELRKNL------------------------- 683
+H E+++ ++Q+LE+ + EL+ +
Sbjct: 1198 KKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLE 1257
Query: 684 EELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLL 743
++L ++K + E+ Q I +L Q + +H E R D EK A++ +L + KQ
Sbjct: 1258 DQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLD-EKDAMVSQLSRGKQ------ 1310
Query: 744 IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK-N 802
A +Q + L+++ E T K L + S + D L+EQY+ E +A E +K N
Sbjct: 1311 -AFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKAN 1369
Query: 803 VEVLASRSN--------TSEQDQAGTEMRVKL--LQEENEKLQGRSEELERRVAQLQRQI 852
EV R+ T E ++A ++ +L +E E + + LE+ +LQ ++
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEV 1429
Query: 853 EDLKGDEAKAK------------------ETLKKYEGEIRQLEEALVHARKEEKEAVSAR 894
EDL D ++ E +KYE +LE + +R E +
Sbjct: 1430 EDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVK 1489
Query: 895 RALE---NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIE 951
A E + LE + QE L+E++ E + +L ++K ++++E+ L ++E
Sbjct: 1490 NAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLE 1549
Query: 952 KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE-------------KTL 998
+ + + E L +Q +L++ K + R++AE +L + TL
Sbjct: 1550 EAEASL----EHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTL 1605
Query: 999 EAE-KSRLTAM----KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS 1053
+AE +SR A+ KM+ ++ ME +L R EAL + + LKD + L+
Sbjct: 1606 DAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAI 1665
Query: 1054 HLKDDRSRLVKQMEDKVSQLEMELEEER-------------------------------- 1081
+DD + +E + + ++ E+EE R
Sbjct: 1666 RGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNT 1725
Query: 1082 ---NNSDLLSERISRSREQMEQL----RN-----------------ELLQERAARQDLEC 1117
N L IS+ + +ME + RN EL +E+ LE
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 1118 DKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNR 1177
K ++E+ KDL+ R+ E + + ++EAR+ ELE +ESE++ R
Sbjct: 1786 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLR 1845
Query: 1178 RLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQR 1234
+ ER+VKEL Q +++ L L D D+L ++KA KRQ EEAEE+ + + +KLQ
Sbjct: 1846 KHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQH 1905
Query: 1235 ELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDD 1269
ELEE + + + Q+N ++ ++ +++ +KV+ +
Sbjct: 1906 ELEEAKERADIAESQVNKLR--VKSREVHTKVISE 1938
Score = 150 bits (380), Expect = 6e-36
Identities = 145/670 (21%), Positives = 317/670 (47%), Gaps = 73/670 (10%)
Query: 612 LLEQKSKLTIEV-AELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTL-- 668
L+++K+ L ++V AE E + Q IK + + + A ++E+ + ++ E N+ L
Sbjct: 884 LMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTA 942
Query: 669 -QQRLEESEGELRKNLE--ELFQVKMEREQHQTE--IRDLQDQLSEMHDELDSAKRSEDR 723
+++LE+ EL+K+++ EL K+E+E+H TE +++L ++++ LD +
Sbjct: 943 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDETIAKLTK 998
Query: 724 EKGALIEELLQAKQDLQDLLIAKEEQEDLLR---KRERELTALKGALKEEVSSHDQEMDK 780
EK AL E +Q L DL + +++ L + K E+++ L+G+L++E ++++
Sbjct: 999 EKKALQE---AHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQE-KKLCMDLER 1054
Query: 781 LKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE 840
K + + +L+ +ES + + + L + E + + + +++ Q +LQ + +E
Sbjct: 1055 AKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE 1114
Query: 841 LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
L+ R+ +L+ +IE + AKA++ E+ ++ E L A + + E E
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 901 LEAAQGNLSQTTQE--------QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 952
+ + +L ++T + +K+ ++ + E EQ + L+R+K ++E E+ L I
Sbjct: 1175 FQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIND 1234
Query: 953 LQKEMADIVEAS---RTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
L M + +A L++QL E K K E QR + E L A+K+RL
Sbjct: 1235 LASNMETVSKAKANFEKMCRTLEDQLSEIKTKEE----EQQRLINE--LSAQKARLHTES 1288
Query: 1010 MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDK 1069
+ +L E++ Q ++ +Q Q +++L+ +LE ++ K + ++
Sbjct: 1289 GEFSRQLDEKDAMVSQLSRG-----KQAFTQQIEELKRQLEEETKAKSTLAHALQSARHD 1343
Query: 1070 VSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL 1129
L + EEE+ L +S++ ++ Q R + E D I + ++
Sbjct: 1344 CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTK----------YETDAIQRTEELEEA 1393
Query: 1130 KSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQ 1189
K ++ R+ + E+ +E+ A+L+ + +RL+ +V++L++
Sbjct: 1394 KKKLAQ------------------RLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMID 1435
Query: 1190 VDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHL 1246
V+ + ++L ++ L K++ EE + E++ + + L EL + + E
Sbjct: 1436 VERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEES 1495
Query: 1247 QGQLNSMKKD 1256
L ++K++
Sbjct: 1496 LDHLETLKRE 1505
Score = 149 bits (376), Expect = 2e-35
Identities = 144/645 (22%), Positives = 299/645 (46%), Gaps = 68/645 (10%)
Query: 618 KLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESE- 676
KL ++ L + + E K N+KEE E+ + L + ++ E E+ TL Q + +
Sbjct: 835 KLYFKIKPLLKSAETE-KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 677 ---------GELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGA 727
+ + ++L + K++ E E+ + + E++ EL + KR
Sbjct: 894 QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK------- 946
Query: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
L +E + K+D+ DL ELT K +++E + + ++ L E
Sbjct: 947 LEDECSELKKDIDDL----------------ELTLAK--VEKEKHATENKVKNLTE---- 984
Query: 788 ELQALRESVEEATKNVEVLASRSNTS------EQDQAGTEMRVKL-LQEENEKLQGRSEE 840
E+ L E++ + TK + L + E+D+ T + K L+++ + L+G E+
Sbjct: 985 EMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQ 1044
Query: 841 LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
++ L+R L+GD A+E+ E + +QL E L +K+E E + L+ +
Sbjct: 1045 EKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKL---KKKEFEMSN----LQGK 1097
Query: 901 LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960
+E Q Q ++ K+L +++E E+ E R + + E +R L + +E++ + +
Sbjct: 1098 IEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE-- 1155
Query: 961 VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ-DEMRLMEE 1019
EA ++ ++ E +K E +M+R L+E TL+ E + K D + + E
Sbjct: 1156 -EAGGATSAQI-----EMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209
Query: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079
++ QR + + ++ L+ + DL +E S K + ++ + +ED++S+++ + EE
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269
Query: 1080 ERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS 1139
++ + LS + +R + + +L ++ A L K + +Q ++LK R + E
Sbjct: 1270 QQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELK-RQLEEETK 1328
Query: 1140 YRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
+S+ + L ++ E E+ +A LQ + +V + + + + + T+
Sbjct: 1329 AKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 1200 Q----KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQM 1240
+ K +L+ RL+ + VE + LE +K++LQ E+E+ M
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433
Score = 124 bits (311), Expect = 6e-28
Identities = 168/783 (21%), Positives = 342/783 (43%), Gaps = 91/783 (11%)
Query: 525 KTFPSASNTQAT-PDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVF 582
KT + T+A +L + L Q+ N+ + Q + L + D K K+ L
Sbjct: 862 KTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLE- 920
Query: 583 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ---LQLEVKNQQN 639
KI+ + RA + N +L +K KL E +EL++ L+L + +
Sbjct: 921 AKIKEVTERAEDEEEIN----------AELTAKKRKLEDECSELKKDIDDLELTLAKVEK 970
Query: 640 IKEERERMRANLEELRSQHNEKV----EENSTLQQRLEESEGELRKNLEELFQVKMEREQ 695
K E NL E + +E + +E LQ+ +++ +L+ +++ + + +
Sbjct: 971 EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTK 1030
Query: 696 HQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK 755
+ ++ DL+ L + +R++ + +G +L A++ D K++ + L+K
Sbjct: 1031 LEQQVDDLEGSLEQEKKLCMDLERAKRKLEG----DLKLAQESTMDTENDKQQLNEKLKK 1086
Query: 756 RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQ 815
+E E++ L+G +++E + Q K+K ELQA E +EE E+ A R++ +
Sbjct: 1087 KEFEMSNLQGKIEDEQALAIQLQKKIK-----ELQARIEELEE-----EIEAERASRA-- 1134
Query: 816 DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQ 875
K + + +L R + ++ ++E+ G + E KK E E ++
Sbjct: 1135 -----------------KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1177
Query: 876 LEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRL 935
+ L + + + +A R + A G + Q KQ E KE+SE K ++ L
Sbjct: 1178 MRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLE--KEKSELKMEINDL 1235
Query: 936 KNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQ---NQLDEYKEKNRRELAEMQRQ 992
+ ME EK+ + + D + +T E Q N+L K + E E RQ
Sbjct: 1236 ASNMETVS-KAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQ 1294
Query: 993 LKEKTLEAEKSRLT------AMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE 1046
L EK +A S+L+ ++++ R +EEE + + R + + E
Sbjct: 1295 LDEK--DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYE 1352
Query: 1047 YELEAKSHLKDDRSRLVKQM-------EDKVSQLEMELEEERNNSDLLSERISRSREQME 1099
E EAK+ L+ S+ ++ E Q ELEE + L++R+ + E +E
Sbjct: 1353 EEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKK---LAQRLQDAEEHVE 1409
Query: 1100 QLRNELLQERAARQDLECD----KISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARI 1155
+ ++ +Q L+ + I +ER N + I L+ R+ + ++ + + +
Sbjct: 1410 AVNSKCASLEKTKQRLQNEVEDLMIDVERSN----AACIALDKKQRNF-DKVLAEWKQKY 1464
Query: 1156 AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD---EHLSLTDQKDQLSLRLKAMK 1212
E + LE+ +++ +L +++ +E + ++ E+ +L + L+ ++
Sbjct: 1465 EETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGG 1524
Query: 1213 RQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDD 1272
+ + E E+ +L+ K +LQ LEE EH +G++ ++ L L ++ S++ + +
Sbjct: 1525 KHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI--LRIQLELNQVKSEIDRKIAE 1582
Query: 1273 DDD 1275
D+
Sbjct: 1583 KDE 1585
Score = 80.1 bits (196), Expect = 1e-14
Identities = 78/359 (21%), Positives = 171/359 (47%), Gaps = 64/359 (17%)
Query: 952 KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ 1011
KL ++ +++++ T E+ N +E+ EK + ELA+ + + KE E+ +T M+ +
Sbjct: 835 KLYFKIKPLLKSAETEK-EMANMKEEF-EKTKEELAKTEAKRKE----LEEKMVTLMQEK 888
Query: 1012 DEMRLM----EEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQME 1067
++++L + L D + D+ + + LE +K++ E + + + + +++E
Sbjct: 889 NDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE 948
Query: 1068 DKVSQLEMEL----------EEERNNSDLLSERISRSREQMEQLRNELLQERAARQD--- 1114
D+ S+L+ ++ E+E++ ++ + ++ +++ +L +E+ A Q+
Sbjct: 949 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 1115 -------LECDKIS-LERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLE--- 1163
+E DK++ L + L+ ++ LEGS K+ L + +E +LE L+
Sbjct: 1009 QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKK-LCMDLERAKRKLEGDLKLAQ 1067
Query: 1164 ----SEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAE 1219
E D+ L ++ E ++ L +++DE QL ++K ++ ++EE E
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAI----QLQKKIKELQARIEELE 1123
Query: 1220 EEID-------RLESSKKKLQRELEE--------------QMDMNEHLQGQLNSMKKDL 1257
EEI+ + E + L RELEE Q++MN+ + + M++DL
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1182
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 190 bits (482), Expect = 9e-48
Identities = 188/756 (24%), Positives = 335/756 (44%), Gaps = 136/756 (17%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
+ K VAEL Q+ + +Q +++E+ + L+++ S + ++ + L++
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQA 735
E ++ ++ + + E+ Q + DL Q +++ E R D EK ALI +L +
Sbjct: 1253 EDQMNEH-------RSKAEETQRSVNDLTSQRAKLQTENGELSRQLD-EKEALISQLTRG 1304
Query: 736 KQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRES 795
K L ++ EDL R+ E E+ A K AL + S + D L+EQY+ E +A E
Sbjct: 1305 K------LTYTQQLEDLKRQLEEEVKA-KNALAHALQSARHDCDLLREQYEEETEAKAEL 1357
Query: 796 VEEATK-NVEVLASRSN--------TSEQDQAGTEMRVKLLQEEN--EKLQGRSEELERR 844
+K N EV R+ T E ++A ++ +L + E E + + LE+
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 845 VAQLQRQIEDLKGDEAKAK------------------ETLKKYEGEIRQLEEALVHARKE 886
+LQ +IEDL D ++ E +KYE +LE + AR
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477
Query: 887 EKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQK-------EQLRRLKNEM 939
E + A E LE +L +E K L E++ + +EQ +L +++ ++
Sbjct: 1478 STELFKLKNAYEESLE----HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1533
Query: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEK--- 996
E E+ L +E+ + + E L Q + ++ K + R+LAE ++++
Sbjct: 1534 EAEKMELQSALEEAEASL----EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1589
Query: 997 ----------TLEAE-KSRLTAM----KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQT 1041
+L+AE +SR A+ KM+ ++ ME +L R EA + + L+
Sbjct: 1590 HLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSL 1649
Query: 1042 LKDLEYELE----AKSHLKD--------------------------DRSRLV-------- 1063
LKD + +L+ A LK+ +RSR +
Sbjct: 1650 LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1709
Query: 1064 ------------------KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNEL 1105
K+M+ +SQL+ E+EE E+ ++ + EL
Sbjct: 1710 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1769
Query: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
+E+ LE K ++E+ KDL+ R+ E + + ++EAR+ ELE+ LE+E
Sbjct: 1770 KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE 1829
Query: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEI 1222
++ A R+ ER++KEL Q +++ L L D D+L L++KA KRQ EEAEE+
Sbjct: 1830 QKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA 1889
Query: 1223 DRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
+ S +K+Q EL+E + + + Q+N ++ R
Sbjct: 1890 NTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
Score = 149 bits (376), Expect = 2e-35
Identities = 161/734 (21%), Positives = 335/734 (45%), Gaps = 83/734 (11%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
+V L + K KL +V +L+ L+ E K + +++ + ++ +L+ + + +
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075
Query: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDS---AKRSEDRE 724
L +RL++ + EL + + Q Q ++++LQ ++ E+ +EL++ A+ ++
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135
Query: 725 KGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHD--------- 775
+ L EL + + L++ A Q ++ +KRE E ++ L+E H+
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195
Query: 776 ------------QEMDKLKEQYDAELQALRESVEEATKNVE-VLASRSNTSE-----QDQ 817
+ ++K++ + E + +++ T N+E ++ +++N + +DQ
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQ 1255
Query: 818 AG----------------TEMRVKLLQEENEKLQGRSEELERRVAQLQR-------QIED 854
T R K LQ EN +L + +E E ++QL R Q+ED
Sbjct: 1256 MNEHRSKAEETQRSVNDLTSQRAK-LQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 855 LK---GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ- 910
LK +E KAK L R + L R++ +E A+ L+ L A ++Q
Sbjct: 1315 LKRQLEEEVKAKNALAHALQSARHDCDLL---REQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 911 TTQEQKQLSEKLKEESEQKEQLRRLKNEMEN-------ERWHLGKTIEKLQKEMADI-VE 962
T+ + ++ +E E K++L + E E + L KT +LQ E+ D+ V+
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1431
Query: 963 ASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELR 1022
R++ LD+ + + LAE +++ +E E E S+ A + E+ ++
Sbjct: 1432 VERSNAAAA--ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1489
Query: 1023 DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERN 1082
+ + + + L++ + DL +L + + ++ KQ+E + +L+ LEE
Sbjct: 1490 ESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA 1549
Query: 1083 NSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 1142
+ + +I R++ + Q++ E ++ + A +D E ++ + + + S L+ RS
Sbjct: 1550 SLEHEEGKILRAQLEFNQIKAE-IERKLAEKDEEMEQ-AKRNHLRVVDSLQTSLDAETRS 1607
Query: 1143 SKEGLVV--QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ 1200
E L V +ME + E+E +L R A Q + L+ +K+ +Q+DD + D
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 1201 KDQLSL---RLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSM---- 1253
K+ +++ R ++ ++EE +++ E S+K ++EL E + + L Q S+
Sbjct: 1668 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1727
Query: 1254 -KKDLRLKKLPSKV 1266
K D L +L ++V
Sbjct: 1728 KKMDADLSQLQTEV 1741
Score = 145 bits (366), Expect = 2e-34
Identities = 158/679 (23%), Positives = 318/679 (46%), Gaps = 59/679 (8%)
Query: 590 SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIK-------- 641
SR Q ++ + E K LLE++ L V + + + VKN +K
Sbjct: 782 SRIITRIQAQSRGVLARMEYKKLLERRDSLL--VIQWNIRAFMGVKNWPWMKLYFKIKPL 839
Query: 642 ---EERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQT 698
ERE+ A+++E E + L++ LE+SE ++ E++ + E+ Q
Sbjct: 840 LKSAEREKEMASMKE----------EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 699 EIRDLQDQLSEMHDELDSAKRSEDREKGALIE--ELLQAKQDLQDLLIAKEEQ-EDLLRK 755
+++ QD L++ + D +++ + + + E E L+ ++++ L AK+ + ED +
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 949
Query: 756 RERELTALKGAL-KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSE 814
+R++ L+ L K E H E +K+K + E+ L E + + TK + L +
Sbjct: 950 LKRDIDDLELTLAKVEKEKHATE-NKVKNLTE-EMAGLDEIIAKLTKEKKALQEAHQQAL 1007
Query: 815 QDQAGTEMRVKLLQEENEKLQGRSEELERRVAQ-------LQRQIEDLKGDEAKAKETLK 867
D E +V L + KL+ + ++LE + Q L+R L+GD +E++
Sbjct: 1008 DDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM 1067
Query: 868 KYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESE 927
E + +QL+E L +K++ E AL +E Q SQ ++ K+L +++E E
Sbjct: 1068 DLENDKQQLDERL---KKKDFEL----NALNARIEDEQALGSQLQKKLKELQARIEELEE 1120
Query: 928 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA 987
+ E R + ++E R L + +E++ + + EA +++++ E +K E
Sbjct: 1121 ELEAERTARAKVEKLRSDLSRELEEISERLE---EAGGATSVQI-----EMNKKREAEFQ 1172
Query: 988 EMQRQLKEKTLEAEKSRLTAMKMQ-DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE 1046
+M+R L+E TL+ E + K D + + E++ + QR + + ++ + L D+
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1232
Query: 1047 YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE-ERNNSDLLSERISRSREQMEQLRNEL 1105
+E K + ++ + +ED++++ + EE +R+ +DL S+R E E L +L
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE-LSRQL 1291
Query: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
++ A L K++ +Q +DLK R + E +++ + L ++ E E
Sbjct: 1292 DEKEALISQLTRGKLTYTQQLEDLK-RQLEEEVKAKNALAHALQSARHDCDLLREQYEEE 1350
Query: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ----KDQLSLRLKAMKRQVEEAEEE 1221
+A LQ + +V + + + + + T++ K +L+ RL+ + VE +
Sbjct: 1351 TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAK 1410
Query: 1222 IDRLESSKKKLQRELEEQM 1240
LE +K +LQ E+E+ M
Sbjct: 1411 CSSLEKTKHRLQNEIEDLM 1429
Score = 68.9 bits (167), Expect = 3e-11
Identities = 44/176 (25%), Positives = 91/176 (51%), Gaps = 9/176 (5%)
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL- 1147
+ ++ +E+ +L+ L + A R++LE +SL ++ DL+ ++ + + ++E
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD 906
Query: 1148 -----VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT---D 1199
+Q+EA++ E+ +RLE EE A L R+LE + EL +DD L+L
Sbjct: 907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK 966
Query: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKK 1255
+K ++K + ++ +E I +L KK LQ ++ +D + + ++N++ K
Sbjct: 967 EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTK 1022
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 188 bits (477), Expect = 3e-47
Identities = 206/938 (21%), Positives = 407/938 (43%), Gaps = 139/938 (14%)
Query: 430 LSQERRGKQSVGRTFAKLQGAAHGA--SCAHSRPPQPNIDGKVLETEGSQESTVIRAPSL 487
L QE++ + + R KL+G A S + +D K+ + E
Sbjct: 1042 LEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMS--------- 1092
Query: 488 GAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELT 547
G QSK E+E + L + + + ++I + A + DL + +E++
Sbjct: 1093 GLQSKIEDE-QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1151
Query: 548 QQTNEE---TAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQ-TLKSRAAGSAQGNNQAC 603
++ E T+ QI N +E + L E TL+ + A S +
Sbjct: 1152 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1211
Query: 604 NSTSEVKDLLE-QKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEK- 661
++ VK LE +KS++ +E+ +L ++ K + N+++ + L E++++ E+
Sbjct: 1212 DNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQ 1271
Query: 662 --VEENSTLQQRLEESEGELRKNLEE----LFQVKMEREQHQTEIRDLQDQLSEMHDELD 715
+ + + + RL+ GE + L+E + Q+ ++ +I +L+ QL E
Sbjct: 1272 RLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE------ 1325
Query: 716 SAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHD 775
E + K AL L ++ D DLLR++ E K L+ +S +
Sbjct: 1326 -----EIKAKSALAHALQSSRHDC-----------DLLREQYEEEQEAKAELQRAMSKAN 1369
Query: 776 QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
E+ + + +Y+ + E +EEA K LA R +E+ + L++ ++LQ
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKK---LAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426
Query: 836 GRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR 895
E+L V + L + + L +++ + + L ++KE + +
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486
Query: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQK-------EQLRRLKNEMENERWHLGK 948
++N E + L +E K L +++ + +EQ +L ++K ++E E+ L
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA 1546
Query: 949 TIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE------------- 995
+E+ + + E L +Q +L++ K + R++AE ++ +
Sbjct: 1547 ALEEAEASL----EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQ 1602
Query: 996 KTLEAE-KSRLTAMKMQDEM---------------RLMEEELRDYQRAQ----------D 1029
TL+AE +SR A++++ +M R+ E LR+Y+ Q D
Sbjct: 1603 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLD 1662
Query: 1030 EALTKRQ--------------LLEQTLKDLEYELE--------AKSHLKDDRSRLV---- 1063
+AL ++ LL+ +++L LE A+ L D R+
Sbjct: 1663 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1722
Query: 1064 ---------KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
K++E +SQ++ E+E+ + E+ ++ + EL +E+
Sbjct: 1723 QNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782
Query: 1115 LECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQL 1174
LE K +LE+ KDL+ R+ E + + ++EAR+ ELE +ESE++
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842
Query: 1175 SNRRLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 1231
R+ ERKVKEL Q +++ L L D D+L ++K+ KRQ EEAEE+ + S ++
Sbjct: 1843 GLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRR 1902
Query: 1232 LQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDD 1269
+Q ELEE + + + Q+N ++ ++ +++ +K++ +
Sbjct: 1903 IQHELEEAEERADIAESQVNKLR--VKSREVHTKIISE 1938
Score = 157 bits (398), Expect = 5e-38
Identities = 159/688 (23%), Positives = 328/688 (47%), Gaps = 57/688 (8%)
Query: 610 KDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEE-------RERMRANLEELRSQHNEKV 662
K+L E+ L E +LQ Q+Q E + + +E + ++ A ++E+ + ++
Sbjct: 875 KELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 934
Query: 663 EENSTL---QQRLEESEGELRKNLE--ELFQVKMEREQHQTE--IRDLQDQLSEMHDELD 715
E N+ L +++LE+ EL+K+++ EL K+E+E+H TE +++L ++++ LD
Sbjct: 935 EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLD 990
Query: 716 SAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKR----ERELTALKGALKEEV 771
+EK AL E Q DLQ A+E++ + L K E+++ L+G+L++E
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQ----AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK 1046
Query: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN 831
++++ K + + +L+ +ES + + + L + E + +G + +++ Q
Sbjct: 1047 KIR-MDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALG 1105
Query: 832 EKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAV 891
+LQ + +EL+ R+ +L+ +IE + AKA++ E+ ++ E L A +
Sbjct: 1106 MQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1165
Query: 892 SARRALENELEAAQGNLSQTTQE--------QKQLSEKLKEESEQKEQLRRLKNEMENER 943
+ E E + + +L + T + +K+ ++ + E EQ + L+R+K ++E E+
Sbjct: 1166 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1225
Query: 944 WHLGKTIEKLQKEMADIVEAS---RTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEA 1000
+ I+ L M + +A L++QL E K K E QR + + L A
Sbjct: 1226 SEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE----EQQRLIND--LTA 1279
Query: 1001 EKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060
+++RL + +L E++ Q ++ + +Q +E+ + LE E++AKS L +
Sbjct: 1280 QRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ-IEELKRQLEEEIKAKSAL----A 1334
Query: 1061 RLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAAR-QDLECDK 1119
++ L + EEE+ L +S++ ++ Q R + + R ++LE K
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 1120 ISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL 1179
L ++ +D + + + +S E +++ + +L +E A L R
Sbjct: 1395 KKLAQRLQDAEEHVEAVNAKC-ASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF 1453
Query: 1180 ERKVKELVMQVDDEHLSL-TDQKD--QLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRE- 1235
++ + E + ++ H L QK+ LS L +K EE+ ++++ L+ K LQ+E
Sbjct: 1454 DKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEI 1513
Query: 1236 --LEEQMDMNEHLQGQLNSMKKDLRLKK 1261
L EQ+ +L +KK + +K
Sbjct: 1514 SDLTEQIAEGGKRIHELEKIKKQVEQEK 1541
Score = 144 bits (364), Expect = 4e-34
Identities = 171/726 (23%), Positives = 343/726 (47%), Gaps = 76/726 (10%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEE-LRSQHNE------ 660
+++ LEQ+ K+ +++ +R+L+ ++K Q + E + L+E L+ + E
Sbjct: 1037 DLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQS 1096
Query: 661 KVEENSTLQQRLEESEGELRKNLEEL-FQVKMER------EQHQTEIRDLQDQLSEMHDE 713
K+E+ L +L++ EL+ +EEL +++ ER E+ ++++ +++SE +E
Sbjct: 1097 KIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 714 LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSS 773
A ++ E + ++DL++ + E LRK+ + A G + +
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1216
Query: 774 HDQEMDKLKEQYDAELQAL---RESVEEATKNVEVLA-------SRSNTSEQDQAG---- 819
Q+++K K + E+ L E+V +A N+E + S T E++Q
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276
Query: 820 -TEMRVKLLQEENEKLQGRSEELERRVAQLQR-------QIEDLK---GDEAKAKETLKK 868
T R + LQ E+ + + +E + V+QL R QIE+LK +E KAK L
Sbjct: 1277 LTAQRAR-LQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAH 1335
Query: 869 YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ-TTQEQKQLSEKLKEESE 927
R + L +EE+E A+ L+ + A ++Q T+ + ++ +E E
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQE---AKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEE 1392
Query: 928 QKEQL-RRLKNEMEN------ERWHLGKTIEKLQKEMADI-VEASRTSTLELQNQLDEYK 979
K++L +RL++ E+ + L KT ++LQ E+ D+ ++ RT+ LD+ +
Sbjct: 1393 AKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNA--ACAALDKKQ 1450
Query: 980 EKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL-- 1037
+ LAE +++ +E E E S Q E R + EL + A +E+L + +
Sbjct: 1451 RNFDKILAEWKQKCEETHAELEAS-------QKESRSLSTELFKIKNAYEESLDQLETLK 1503
Query: 1038 -----LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092
L+Q + DL ++ + ++ KQ+E + S+L+ LEE + + +I
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKIL 1563
Query: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEG--LVVQ 1150
R + ++ Q+++E + + A +D E D++ + ++S L+ RS + L +
Sbjct: 1564 RIQLELNQVKSE-VDRKIAEKDEEIDQMK-RNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1621
Query: 1151 MEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSL---R 1207
ME + E+E +L R A + R + +K+ + +DD S D K+QL++ R
Sbjct: 1622 MEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERR 1681
Query: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSM-KKDLRLKKLPSKV 1266
++ ++EE +++ E S+K ++EL + + + L Q S+ +L+ S++
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI 1741
Query: 1267 LDDMDD 1272
+M+D
Sbjct: 1742 QGEMED 1747
Score = 126 bits (317), Expect = 1e-28
Identities = 166/774 (21%), Positives = 339/774 (43%), Gaps = 73/774 (9%)
Query: 525 KTFPSASNTQAT-PDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVF 582
KT + T+A +L + L Q+ N+ + Q + L + D K K+ L
Sbjct: 862 KTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLE- 920
Query: 583 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSK----LTIEVAELQRQLQLEVKNQQ 638
KI+ + RA + N + +++D + K L + +A+++++ +
Sbjct: 921 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980
Query: 639 NIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQT 698
N+ EE + + +L + E + QQ L++ + E K + L + K++ EQ
Sbjct: 981 NLTEEMAGLDETIAKLTKEKKALQEAH---QQTLDDLQAEEDK-VNTLTKAKIKLEQ--- 1033
Query: 699 EIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRER 758
++ DL+ L ++ + +R K L +L A++ D+ K++ ++ L+K+E
Sbjct: 1034 QVDDLEGSL----EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEF 1089
Query: 759 ELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQA 818
E++ L+ +++E + Q K+K ELQA E +EE E+ A R++ +
Sbjct: 1090 EMSGLQSKIEDEQALGMQLQKKIK-----ELQARIEELEE-----EIEAERASRA----- 1134
Query: 819 GTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEE 878
K + + +L R + ++ ++E+ G + E KK E E +++
Sbjct: 1135 --------------KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 879 ALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE 938
L A + + + R + A G Q KQ E KE+SE K ++ L +
Sbjct: 1181 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE--KEKSEMKMEIDDLASN 1238
Query: 939 MENERWHLGKTIEKLQKEMADIVEASRTSTLELQ---NQLDEYKEKNRRELAEMQRQLKE 995
ME G +EK+ + + D + +T E Q N L + + + E E RQL E
Sbjct: 1239 METVSKAKG-NLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE 1297
Query: 996 K-TLEAEKSR---LTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA 1051
K TL ++ SR ++++ R +EEE++ + R + + E E EA
Sbjct: 1298 KDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEA 1357
Query: 1052 KSHLKDDRSRLVKQM-------EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNE 1104
K+ L+ S+ ++ E Q ELEE + L++R+ + E +E + +
Sbjct: 1358 KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKK---LAQRLQDAEEHVEAVNAK 1414
Query: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLES 1164
+Q L+ + L + + L+ R+ + ++ + + + E LE+
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF-DKILAEWKQKCEETHAELEA 1473
Query: 1165 EERDRANLQLSNRRLERKVKELVMQVDD---EHLSLTDQKDQLSLRLKAMKRQVEEAEEE 1221
+++ +L +++ +E + Q++ E+ +L + L+ ++ +++ E E+
Sbjct: 1474 SQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1533
Query: 1222 IDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDD 1275
++E K +LQ LEE EH +G++ ++ L L ++ S+V + + D+
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEHEEGKI--LRIQLELNQVKSEVDRKIAEKDE 1585
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/176 (25%), Positives = 90/176 (51%), Gaps = 9/176 (5%)
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL- 1147
+ ++ +E+ E+ + EL + A R++LE ++L ++ DL+ ++ S ++E
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCD 910
Query: 1148 -----VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT---D 1199
+Q+EA+I E+ +R E EE A L R+LE + EL +DD L+L
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 970
Query: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKK 1255
+K ++K + ++ +E I +L KK LQ ++ +D + + ++N++ K
Sbjct: 971 EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1026
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 186 bits (472), Expect = 1e-46
Identities = 183/811 (22%), Positives = 353/811 (43%), Gaps = 113/811 (13%)
Query: 538 DLLKGQQELTQQTNEE---TAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQ-TLKSRAA 593
DL + +E++++ E T+ QI N +E + L E TL+ + A
Sbjct: 1142 DLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA 1201
Query: 594 GSAQGNNQACNSTSEVKDLLE-QKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLE 652
S + ++ VK LE +KS+L +E+ ++ ++ K++ NI+ +
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFS 1261
Query: 653 ELRS---QHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSE 709
E+++ Q + + + + + RL+ GEL +EE +E +++ + L++
Sbjct: 1262 EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE-------KESLISQLTKSKQALTQ 1314
Query: 710 MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE 769
+EL E + K A+ L ++ D DLLR++ E K L+
Sbjct: 1315 QLEELKRQMEEETKAKNAMAHALQSSRHDC-----------DLLREQYEEEQEAKAELQR 1363
Query: 770 EVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQE 829
+S + E+ + + +Y+ + E +EEA K LA R +E++ + L++
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKK---LAQRLQEAEENTETANSKCASLEK 1420
Query: 830 ENEKLQGRSEELERRVAQL----------QRQIEDL------KGDEAKAKETLKKYEGEI 873
++LQG E+L R + + QR + + K DE++A+ L+ + E
Sbjct: 1421 TKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAE--LEAAQKES 1478
Query: 874 RQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE--- 930
R L L R +E V L E + Q +S T++ + + L+E + K+
Sbjct: 1479 RSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVE 1538
Query: 931 -----------------------------QLRRLKNEMENERWHLGKTIEKLQKEMADIV 961
+L ++K+E++ + + IE+L++
Sbjct: 1539 QEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAA 1598
Query: 962 EA----------SRTSTLELQ-------NQLDEYKEKNRRELAEMQR-------QLKEKT 997
EA SR L L+ N+++ + R++AE Q+ QLK+
Sbjct: 1599 EALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQ 1658
Query: 998 LEAEKSRLTAMKMQDEMRLME-------EELRDYQRAQDEALTKRQLLEQTLKDLEYELE 1050
L + + + +++++ ++E EEL + + A ++ R+L EQ L D ++
Sbjct: 1659 LHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQ 1718
Query: 1051 AKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERA 1110
K++E ++Q + E+E S E+ ++ + EL +E+
Sbjct: 1719 LLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQD 1778
Query: 1111 ARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRA 1170
LE K +LE+ KDL+ R+ E + + ++E R+ ELE+ L+ E++ A
Sbjct: 1779 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGA 1838
Query: 1171 NLQLSNRRLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLES 1227
+ ERKVKE+ Q +++H L L D D+L ++K+ KRQ EEAEE+ + S
Sbjct: 1839 EALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLS 1898
Query: 1228 SKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
+++Q ELEE + + + Q+N ++ R
Sbjct: 1899 RCRRVQHELEEAAERADIAESQVNKLRAKSR 1929
Score = 152 bits (385), Expect = 2e-36
Identities = 147/640 (22%), Positives = 309/640 (48%), Gaps = 60/640 (9%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
K K ++ AE ++++ ++ + KEE R A +EL + ++E + LQ +++
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 676 EGEL---RKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
L + E L + K+ E E+ + ++ EM+ EL + KR+ + + +L
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL---- 954
Query: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
K+D+ DL ELT K +++E + + ++ L E E+ AL
Sbjct: 955 ---KRDIDDL----------------ELTLTK--VEKEKHATENKVKNLSE----EMTAL 989
Query: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRV------- 845
E++ + TK + L + D E +V L + N KL+ ++++LE +
Sbjct: 990 EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLR 1049
Query: 846 AQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQ 905
A L+R L+GD ++E++ E + +Q+EE L +K+E E + +++E Q
Sbjct: 1050 ADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL---KKKEFELSQLQAKIDDE----Q 1102
Query: 906 GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965
+ Q ++ K+L +++E E+ E L+ ++E +R L + +E++ + + EAS
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE---EASG 1159
Query: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ-DEMRLMEEELRDY 1024
++ ++ E +K E +M+R L+E TL+ E + T K Q D + + E++ +
Sbjct: 1160 ATSAQI-----EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNL 1214
Query: 1025 QRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNS 1084
QR + + ++ L+ + D+ +EA S K + R + +ED+ S+++ + E++
Sbjct: 1215 QRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLI 1274
Query: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSK 1144
L+ + +R + Q +L + + ++ + L K +L +Q ++LK R + E +++
Sbjct: 1275 HDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK-RQMEEETKAKNAM 1333
Query: 1145 EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ---- 1200
+ L ++ E E+ +A LQ + + +V + + + + + T++
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 1201 KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQM 1240
K +L+ RL+ + E A + LE +K++LQ E+E+ M
Sbjct: 1394 KKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433
Score = 142 bits (359), Expect = 2e-33
Identities = 172/792 (21%), Positives = 342/792 (43%), Gaps = 125/792 (15%)
Query: 544 QELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVN---LVFEKIQTLKSRAAGSAQGNN 600
+ELT++ EE K D + KR ++ L K++ K N
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHAT------EN 977
Query: 601 QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE 660
+ N + E+ L E SKLT K +++++E ++ +L+ + N
Sbjct: 978 KVKNLSEEMTALEENISKLT--------------KEKKSLQEAHQQTLDDLQVEEDKVNG 1023
Query: 661 KVEENSTLQQRLEE---------------------SEGELRKNLEELFQVKMEREQHQTE 699
++ N+ L+Q+ ++ EG+L+ + E + ++ +++Q + +
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Query: 700 IRDLQDQLSEMHDELDSAK------RSEDREKGALIEELLQAKQDLQDLLIAKEEQE--D 751
++ + +LS++ ++D + + + +E A IEE L+ + + + L AK E++ D
Sbjct: 1084 LKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE-LEEEIEAEHTLRAKIEKQRSD 1142
Query: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811
L R+ E L EE S ++ ++ +AE Q +R +EEAT E A+
Sbjct: 1143 LARELEEISERL-----EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 812 TSEQDQ-AGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYE 870
+ D A ++ LQ +KL+ EL+ + + IE L ++ + T + E
Sbjct: 1198 KKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVE 1257
Query: 871 GEIRQL------EEALVHARKEEKEAVSARRA-LENELEAAQGNLSQTTQEQKQLSEKLK 923
+ ++ + L+H +K + + L + +E + +SQ T+ ++ L+++L+
Sbjct: 1258 DQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE 1317
Query: 924 EESEQKEQLRRLKNEM---------------------ENERWHLGKTIEKLQKEMADIVE 962
E Q E+ + KN M + + L + + K E+A
Sbjct: 1318 ELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRT 1377
Query: 963 ASRTSTLELQNQLDEYKEKNRRELAEMQRQL-----KEKTLEAEKSRLTAMKMQDEMRLM 1017
T ++ +L+E K+K + L E + K +LE K RL +++D MR +
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQG-EVEDLMRDL 1436
Query: 1018 EEE------LRDYQRAQDEALTK-RQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKV 1070
E L QR D+ L + +Q L+++ +LE + L + ++ E+ V
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV 1496
Query: 1071 SQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLK 1130
QLE E +N L E IS EQ+ + L Q+ E K +E++ DL+
Sbjct: 1497 DQLETLRRENKN----LQEEISDLTEQIAETGKNL-------QEAEKTKKLVEQEKSDLQ 1545
Query: 1131 SRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE--ERDRANLQLSNRRLERKVKELVM 1188
+ +EGS +E +++++ +++++ L+ + E+D QL R +R + L
Sbjct: 1546 VALEEVEGSL-EHEESKILRVQLELSQVKSELDRKVIEKDEEIEQL-KRNSQRAAEALQS 1603
Query: 1189 QVDDEHLSLTD----------QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE 1238
+D E S D +++ ++L RQ+ E ++ + ++ K Q L++
Sbjct: 1604 VLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDD 1663
Query: 1239 QMDMNEHLQGQL 1250
+ NE L+ QL
Sbjct: 1664 ALRSNEDLKEQL 1675
Score = 140 bits (353), Expect = 8e-33
Identities = 191/852 (22%), Positives = 367/852 (43%), Gaps = 151/852 (17%)
Query: 541 KGQQELTQQTNEETAKQ-------ILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAA 593
K QE QQT ++ + I N E TD+ + + + + ++ K +
Sbjct: 1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE 1060
Query: 594 GSAQGNNQACNSTSEVKDLLEQK-SKLTIEVAELQRQLQLE----VKNQQNIKEERERMR 648
G + + ++ K +E+K K E+++LQ ++ E ++ Q+ IKE + R+
Sbjct: 1061 GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE 1120
Query: 649 ANLEELRSQHN--EKVEENST--------LQQRLEESEG------ELRKNLEELFQVKME 692
EE+ ++H K+E+ + + +RLEE+ G E+ K E FQ KM
Sbjct: 1121 ELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ-KMR 1179
Query: 693 RE------QHQTEIRDLQD-------QLSEMHDELDSAKRSEDREKGAL----------I 729
R+ QH+ L+ +L E D L K+ ++EK L I
Sbjct: 1180 RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNI 1239
Query: 730 EELLQAKQDLQDLLIAKEEQEDLLRKRERELTAL-------KGALKE---EVSSHDQEMD 779
E L ++K +++ E+Q ++ ++ + T L K L+ E+S +E +
Sbjct: 1240 EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKE 1299
Query: 780 KLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSE 839
L Q QAL + +EE + +E N + LL+E+ E+ Q
Sbjct: 1300 SLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKA 1359
Query: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALEN 899
EL+R +++ ++ + KYE + Q E
Sbjct: 1360 ELQRALSKANSEVAQWR----------TKYETDAIQRTE--------------------- 1388
Query: 900 ELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR-RLKNEMEN-----ERWHLG-KTIEK 952
ELE A+ L+Q QE ++ +E + E+ + RL+ E+E+ ER H T++K
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDK 1448
Query: 953 LQKEMADIVEASRTSTLELQNQLDEYKEKNR---RELAEMQRQLKEKTLEAEKSRLTAMK 1009
Q+ ++ + E Q +L+ ++++R EL +M+ +E + E R
Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKN 1508
Query: 1010 MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYEL-EAKSHLKDDRSRLVK---- 1064
+Q+E+ + E++ + + EA ++L+EQ DL+ L E + L+ + S++++
Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLE 1568
Query: 1065 ------QMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQ-ERAARQDLEC 1117
+++ KV + + E+E+ + NS +E + + + RN+ L+ ++ DL
Sbjct: 1569 LSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNE 1628
Query: 1118 DKISLERQNK--------------DLKSRIIHLEGSYRSS---KEGLVVQMEAR----IA 1156
+I L N+ LK +HL+ + RS+ KE L + +E R +
Sbjct: 1629 MEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI-VERRNGLLLE 1687
Query: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
ELE+ + E+ +LS + L + V + ++ SL + K +L + + +VE
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQEL-LDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVE 1746
Query: 1217 EAEEEIDRLESSKKK-------LQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDD 1269
+ +E E KK + EL+++ D + HL+ MKK+ L++ +
Sbjct: 1747 NSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE----RMKKN--LEQTVKDLQHR 1800
Query: 1270 MDDDDDLSTDGG 1281
+D+ + L+ GG
Sbjct: 1801 LDEAEQLALKGG 1812
Score = 138 bits (347), Expect = 4e-32
Identities = 164/750 (21%), Positives = 331/750 (44%), Gaps = 99/750 (13%)
Query: 564 KEGSTDNDDATKRKVNLVFEKIQT--LKSRAAGSAQGNN----QACNSTSEVKDLLEQ-- 615
KE +T +D + K L + + L+ + Q N Q + T + D E+
Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 616 ---KSKLTIE--VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQ 670
KSK+ +E V EL +L EE E M + L ++
Sbjct: 911 GLIKSKILLEAKVKELTERL-----------EEEEEMNSEL--------------VAKKR 945
Query: 671 RLEESEGELRKNLE--ELFQVKMEREQHQTE--IRDLQDQLSEMHDELDSAKRSEDREKG 726
LE+ L+++++ EL K+E+E+H TE +++L ++++ + + + +EK
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKL----TKEKK 1001
Query: 727 ALIEELLQAKQDLQDLLIAKEEQEDLLR---KRERELTALKGALKEEVSSHDQEMDKLKE 783
+L E +Q L DL + +++ L++ K E++ L+G+L++E ++++ K
Sbjct: 1002 SLQE---AHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLR-ADLERAKR 1057
Query: 784 QYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELER 843
+ + +L+ +ES+ + + + + + E + + + ++ Q + + Q + +EL+
Sbjct: 1058 KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQA 1117
Query: 844 RVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEA 903
R+ +L+ +IE AK ++ E+ ++ E L A + + E E +
Sbjct: 1118 RIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQK 1177
Query: 904 AQGNLSQTTQE--------QKQLSEKLKEESEQKEQLRRLKNEMENERWHL-------GK 948
+ +L + T + +K+ ++ + E EQ + L+R+K ++E E+ L
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMAS 1237
Query: 949 TIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM 1008
IE L K ++I RT +++Q E K K+ E Q QL L +K+RL
Sbjct: 1238 NIEALSKSKSNIERTCRT----VEDQFSEIKAKD-----EQQTQLIH-DLNMQKARLQTQ 1287
Query: 1009 KMQDEMRLMEEELRDYQRAQDEALTK-RQLLEQTLKDLEYELEAKSHLKDDRSRLVKQME 1067
+ R+ E+E Q LTK +Q L Q L++L+ ++E ++ K+ + ++
Sbjct: 1288 NGELSHRVEEKESLISQ------LTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSR 1341
Query: 1068 DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
L + EEE+ L +S++ ++ Q R + + R + LE K
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE------ELEEAKK 1395
Query: 1128 DLKSRIIHLE------GSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLER 1181
L R+ E S +S E +++ + +L LE A L R ++
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDK 1455
Query: 1182 KVKELVMQVDDEHLSL-TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQM 1240
+ E ++D+ L QK+ SL + K + EE +D+LE+ +++ + EE
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTELFKMR-NAYEEVVDQLETLRRENKNLQEEIS 1514
Query: 1241 DMNEHLQGQLNSMKKDLRLKKLPSKVLDDM 1270
D+ E + ++++ + KKL + D+
Sbjct: 1515 DLTEQIAETGKNLQEAEKTKKLVEQEKSDL 1544
Score = 130 bits (327), Expect = 8e-30
Identities = 139/648 (21%), Positives = 282/648 (43%), Gaps = 60/648 (9%)
Query: 476 SQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATS-----PDSGAKKISVKTFPSA 530
S+++ + L Q ++E + K A A + +R + K ++ S
Sbjct: 1308 SKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSK 1367
Query: 531 SNTQATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLK 589
+N++ K + + Q+T E E AK+ L L+E + + A + +L + K
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASL-----EKTK 1422
Query: 590 SRAAGSAQG-------NNQACNSTSEV-----KDLLEQKSKLTIEVAELQRQLQLEVKNQ 637
R G + ++ AC + + K L E K KL E Q +L+ K
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLD----ESQAELEAAQKES 1478
Query: 638 QNIKEERERMRANLEELRSQHNEKVEENSTLQQR---LEESEGELRKNLEELFQVKMERE 694
+++ E +MR EE+ Q EN LQ+ L E E KNL+E + K E
Sbjct: 1479 RSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVE 1538
Query: 695 QHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ-EDLL 753
Q ++ DLQ L E+ L+ E+ + + EL Q K +L +I K+E+ E L
Sbjct: 1539 QEKS---DLQVALEEVEGSLEH----EESKILRVQLELSQVKSELDRKVIEKDEEIEQLK 1591
Query: 754 RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTS 813
R +R AL+ L E+ S + + +LK++ + +L + + + + + T
Sbjct: 1592 RNSQRAAEALQSVLDAEIRSRNDAL-RLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTV 1650
Query: 814 EQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEI 873
+ +++ + NE L+ + +ERR L ++E++K + + T + E E+
Sbjct: 1651 QGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQEL 1710
Query: 874 RQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK----EESEQK 929
+ + + ++ ++ LE ++ Q + + QE + EK K + +
Sbjct: 1711 LDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMA 1770
Query: 930 EQLRRLKN---EMENERWHLGKTIEKLQKEMADI-----------VEASRTSTLELQNQL 975
E+L++ ++ +E + +L +T++ LQ + + ++ EL+N+L
Sbjct: 1771 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830
Query: 976 DEYKEKNRRELA---EMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEAL 1032
D +++ L + +R++KE T +AE+ +++QD + ++ +++ Y+R +EA
Sbjct: 1831 DVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAE 1890
Query: 1033 TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
+ + +++ELE + D V ++ K + + EE
Sbjct: 1891 EQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
Score = 99.8 bits (247), Expect = 2e-20
Identities = 93/440 (21%), Positives = 204/440 (46%), Gaps = 66/440 (15%)
Query: 846 AQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEA-VSARRALENELEA- 903
A+ ++++ +K D + KE L + E ++LEE +V +E+ + + + EN ++A
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906
Query: 904 --AQGNLSQTT---QEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
+G + + K+L+E+L+EE E +L K +E++ L + I+ L+ +
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966
Query: 959 DIVEASRTSTLELQNQLDEYKEKN-RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLM 1017
+ E + E K KN E+ ++ + + T E + + + D++++
Sbjct: 967 KV---------EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 1018 EEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMEL 1077
E+++ + + LEQ DLE LE + L+ D R +++E + + +
Sbjct: 1018 EDKVNGLIKINAK-------LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESI 1070
Query: 1078 EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLE 1137
+ N+ + E++ + ++ QL+ ++ E+ SL+ Q K
Sbjct: 1071 MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVH---------SLQFQKK---------- 1111
Query: 1138 GSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSL 1197
+ +++ARI ELE+ +E+E RA ++ L R+++E+ ++++ +
Sbjct: 1112 ----------IKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161
Query: 1198 TDQKDQLSLR---LKAMKRQVEEAEEEIDRLESSKKKLQ----RELEEQMDMNEHLQGQL 1250
+ Q + R + M+R +EEA + + ++ +K Q EL EQ+D + ++ +L
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKL 1221
Query: 1251 NSMKKDLRLKKLPSKVLDDM 1270
K +L+++ +DDM
Sbjct: 1222 EKEKSELKME------IDDM 1235
Score = 73.6 bits (179), Expect = 1e-12
Identities = 51/201 (25%), Positives = 101/201 (50%), Gaps = 10/201 (4%)
Query: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKE--- 1145
+ ++ +E E+ + EL + A R++LE +SL ++ DL+ ++ + ++E
Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 1146 GLV---VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT---D 1199
GL+ + +EA++ EL +RLE EE + L R LE K L +DD L+LT
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEK 970
Query: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSM-KKDLR 1258
+K ++K + ++ EE I +L KK LQ ++ +D + + ++N + K + +
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 1259 LKKLPSKVLDDMDDDDDLSTD 1279
L++ + ++ + L D
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRAD 1051
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 186 bits (471), Expect = 2e-46
Identities = 178/726 (24%), Positives = 322/726 (44%), Gaps = 66/726 (9%)
Query: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAEL 626
S+ + +K K NL EKI A+G N+ + + +L QKS+L E EL
Sbjct: 1233 SSSMESVSKSKANL--EKICRTLEDQLSEARGKNEEIQRS--LSELTTQKSRLQTEAGEL 1288
Query: 627 QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEEL 686
RQL+ + + ++ EEL+ Q E+ + + L L+ S + +L
Sbjct: 1289 SRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDC-----DL 1343
Query: 687 FQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAK 746
+ + E EQ +LQ LS+ + E+ + + + EEL +AK+ L L
Sbjct: 1344 LREQYEEEQEGKA--ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDS 1401
Query: 747 EEQEDLLRKRERELTALKGALKEEV----------SSHDQEMDKLKEQYDAELQALRESV 796
EEQ + + + L K L+ EV +S +DK + +D L +
Sbjct: 1402 EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC 1461
Query: 797 EEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK 856
EE+ +E S + + + + ++ E ++ ++ LE+ +A L QI
Sbjct: 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI---- 1517
Query: 857 GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQK 916
+ K L+K +I +LE+A + EE EA ALE+E + TQ +
Sbjct: 1518 AENGKTIHELEKSRKQI-ELEKADIQLALEEAEA-----ALEHEEAKILRIQLELTQVKS 1571
Query: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976
++ K+ E+ E+ EQL+R + +T+E +Q + D SR + L+ +++
Sbjct: 1572 EIDRKIAEKDEEIEQLKR----------NYQRTVETMQSAL-DAEVRSRNEAIRLKKKME 1620
Query: 977 EYKEKNRRELAEMQRQLKE--KTLEAEKSRL--TAMKMQDEMR----------------- 1015
+ +L+ RQ E K L + + +L T + + D +R
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAN 1680
Query: 1016 LMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEM 1075
L++ E+ + + ++ R+L EQ L D ++ K++E + QL+
Sbjct: 1681 LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740
Query: 1076 ELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIH 1135
E+E+ ++ E+ ++ + EL +E+ LE K +LE+ KDL+ R+
Sbjct: 1741 EVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1800
Query: 1136 LEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEH- 1194
E + + ++E RI ELE LE E++ R+ ER+VKEL Q +++
Sbjct: 1801 AEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRK 1860
Query: 1195 --LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
L L D D+L +++K+ KRQ EEA+E+ + + +K Q ELEE + + + Q+N
Sbjct: 1861 NVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNK 1920
Query: 1253 MKKDLR 1258
++ R
Sbjct: 1921 LRAKTR 1926
Score = 157 bits (398), Expect = 5e-38
Identities = 177/794 (22%), Positives = 363/794 (45%), Gaps = 106/794 (13%)
Query: 572 DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQ 631
D T K+ + +Q +A Q NS ++ K LEQ +V +L+ L+
Sbjct: 987 DETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQ------QVEDLESSLE 1040
Query: 632 LEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKM 691
E K + +++ + ++ +L+ + + + L +RL++ + E + Q K+
Sbjct: 1041 QEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQ-----LQSKV 1095
Query: 692 EREQ-----HQTEIRDLQDQLSEMHDELDSAKRSE---DREKGALIEELLQAKQDLQDLL 743
E EQ Q +I++LQ ++ E+ +E+++ + + ++++ EL + + L++
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 1155
Query: 744 IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD---AEL----------- 789
Q +L +KRE E L+ L+E H+ + L++++ AEL
Sbjct: 1156 GVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVK 1215
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQ 849
Q L + E ++ L+S + + +A E + L+++ + +G++EE++R +++L
Sbjct: 1216 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 1275
Query: 850 RQIEDLKGDEAKAKETLKKYEGEI------------------RQLEE------ALVHA-- 883
Q L+ + + L++ E + RQLEE AL HA
Sbjct: 1276 TQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQ 1335
Query: 884 ---------RKEEKEAVSARRALENELEAAQGNLSQ-TTQEQKQLSEKLKEESEQKEQL- 932
R++ +E + L+ L A ++Q T+ + ++ +E E K++L
Sbjct: 1336 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1395
Query: 933 RRLKNEMEN------ERWHLGKTIEKLQKEMADI-VEASRTSTLELQNQLDEYKEKNRRE 985
+RL++ E + L KT ++LQ E+ D+ V+ R ++L LD+ + +
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAA--ALDKKQRNFDKV 1453
Query: 986 LAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDL 1045
LAE + + +E E E S E R + EL + A +EAL + + +++ K+L
Sbjct: 1454 LAEWKTKCEESQAELEAS-------LKESRSLSTELFKLKNAYEEALDQLETVKRENKNL 1506
Query: 1046 EYELEAKSHLKDDRSRLVKQMEDKVSQLEME-------LEEERNNSDLLSERISRSREQM 1098
E E+ + + + + ++E Q+E+E LEE + +I R + ++
Sbjct: 1507 EQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566
Query: 1099 EQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEG--LVVQMEARIA 1156
Q+++E + + A +D E +++ Q + +++ L+ RS E L +ME +
Sbjct: 1567 TQVKSE-IDRKIAEKDEEIEQLKRNYQ-RTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 1624
Query: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSL---RLKAMKR 1213
E+E +L R A R ++ ++K+ + +DD D K+QL++ R ++
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 1214 QVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL--RLKKLPSKVLDDMD 1271
+VEE +++ E ++K ++EL +D NE +Q L++ L KKL + ++
Sbjct: 1685 EVEELRATLEQTERARKLAEQEL---LDSNERVQ-LLHTQNTSLIHTKKKLETDLMQLQS 1740
Query: 1272 DDDDLSTDGGSLYE 1285
+ +D S D + E
Sbjct: 1741 EVEDASRDARNAEE 1754
Score = 156 bits (394), Expect = 1e-37
Identities = 160/700 (22%), Positives = 325/700 (46%), Gaps = 70/700 (10%)
Query: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE-E 674
K K ++ AE ++++ + Q K+E + A +EL + V+E + LQ +++ E
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE 895
Query: 675 SEG--ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
SE + + ++L + K + E E+ + + E++ EL + KR L +E
Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRK-------LEDEC 948
Query: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAEL 789
+ K+D+ DL E L K E+E A + +K EE+S D+ + KL E
Sbjct: 949 SELKKDIDDL-------ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTR----EK 997
Query: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL- 848
+AL+E+ ++A +++ + N+ + ++ E +V+ L+ E+ + +LER +L
Sbjct: 998 KALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLE 1057
Query: 849 ------QRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL-------VHARKEEKEAVSARR 895
Q I DL+ D+ + E LKK + E QL+ + + +K+ KE +
Sbjct: 1058 GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIE 1117
Query: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR-------RLKNEMENERWHLGK 948
LE E+EA + ++T +++ + +L+E SE+ E+ L + E E L +
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 949 TIEKLQKEMADIVEASR----TSTLELQNQLD---EYKEKNRRELAEMQRQLKEKTLEAE 1001
+E+ + +V A R S EL Q+D K+K +E +E + ++ + + E
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME 1237
Query: 1002 KSRLTAMKMQDEMRLMEEEL-------RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSH 1054
+ ++ R +E++L + QR+ E T++ L+ +L +LE K
Sbjct: 1238 SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKES 1297
Query: 1055 LKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
+ SR + + +L+ +LEEE + L+ + SR + LR + +E+ + +
Sbjct: 1298 IVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 1357
Query: 1115 LECDKISLERQNKDLKSRIIHLEGSYRSSKEGL---VVQMEARIAELEDRLESEERDRAN 1171
L+ +L + N ++ E E L ++ R+ + E+++E+ A+
Sbjct: 1358 LQ---RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS 1414
Query: 1172 LQLSNRRLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESS 1228
L+ + +RL+ +V++L++ V+ + +L ++ L K + EE++ E++
Sbjct: 1415 LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474
Query: 1229 KKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLD 1268
+ L EL + + E QL ++K++ K L ++ D
Sbjct: 1475 SRSLSTELFKLKNAYEEALDQLETVKRE--NKNLEQEIAD 1512
Score = 155 bits (391), Expect = 3e-37
Identities = 182/754 (24%), Positives = 337/754 (44%), Gaps = 111/754 (14%)
Query: 563 LKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIE 622
LK T+ + AT + E+ Q K A S + ++ L+++K+ L ++
Sbjct: 841 LKSAETEKEMATMK------EEFQKTKDELAKSEAKRKEL---EEKLVTLVQEKNDLQLQ 891
Query: 623 V-AELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTL---QQRLEESEGE 678
V AE + L E + Q IK + + + A ++E+ + ++ E N+ L +++LE+ E
Sbjct: 892 VQAESENLLDAEERCDQLIKAKFQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 679 LRKNLE--ELFQVKMEREQHQTE--IRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQ 734
L+K+++ EL K+E+E+H TE +++L ++LS LD REK AL E Q
Sbjct: 951 LKKDIDDLELTLAKVEKEKHATENKVKNLTEELSG----LDETIAKLTREKKALQEAHQQ 1006
Query: 735 AKQDLQ---------------------DLLIAKEEQEDLLRKRERELTALKGALK-EEVS 772
A DLQ DL + E+++ L ER L+G LK + S
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQES 1066
Query: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
D E D K+Q D L+ K+ E +S ++ G + + K+
Sbjct: 1067 ILDLEND--KQQLDERLK---------KKDFEYCQLQSKVEDEQTLGLQFQKKI------ 1109
Query: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA--------- 883
+EL+ R+ +L+ +IE + AK ++ Y E+ +L E L A
Sbjct: 1110 ------KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 1163
Query: 884 --RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN 941
+K E E + RR LE EA + + +K+ ++ + E EQ + L+R+K ++E
Sbjct: 1164 LNKKREAEFLKLRRDLE---EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 942 ERWH-------LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLK 994
E+ L ++E + K A++ + RT L++QL E + KN E+QR L
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRT----LEDQLSEARGKNE----EIQRSLS 1272
Query: 995 EKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSH 1054
E L +KSRL Q E + +L + + + +Q Q ++L+ +LE ++
Sbjct: 1273 E--LTTQKSRL-----QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 1325
Query: 1055 LKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAAR-Q 1113
K+ + ++ L + EEE+ L +S++ ++ Q R + + R +
Sbjct: 1326 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 1385
Query: 1114 DLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQ 1173
+LE K L ++ +D + ++ + +S E +++ + +L +E A L
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKC-ASLEKTKQRLQGEVEDLMVDVERANSLAAALD 1444
Query: 1174 LSNRRLERKVKELVMQVDDEHLSL---TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKK 1230
R ++ + E + ++ L + LS L +K EEA ++++ ++ K
Sbjct: 1445 KKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 1504
Query: 1231 KLQRE---LEEQMDMNEHLQGQLNSMKKDLRLKK 1261
L++E L EQ+ N +L +K + L+K
Sbjct: 1505 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEK 1538
Score = 134 bits (338), Expect = 4e-31
Identities = 163/785 (20%), Positives = 338/785 (43%), Gaps = 88/785 (11%)
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFE---KIQTLKSRAAGSAQGN 599
+++L E+ Q+ E D ++ + + F+ KI+ + RA + N
Sbjct: 875 EEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEIN 934
Query: 600 NQACNSTSEVKDLLEQKSKLTIEVAELQRQ---LQLEVKNQQNIKEERERMRANLEELRS 656
+L +K KL E +EL++ L+L + + K E NL E S
Sbjct: 935 ----------AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELS 984
Query: 657 QHNEKV----EENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSE--- 709
+E + E LQ+ +++ +L+ +++ + + + + ++ DL+ L +
Sbjct: 985 GLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKK 1044
Query: 710 MHDELDSAKRSEDREKGALIEELLQAKQDLQDL-------------LIAKEEQEDLL--- 753
+ +L+ KR + + E +L + D Q L L +K E E L
Sbjct: 1045 LRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQ 1104
Query: 754 -RKRERELTALKGALKEEVSSH---DQEMDKLKEQYDAELQALRESVEEA--TKNVEVLA 807
+K+ +EL A L+EE+ + + +K + Y EL+ L E +EEA + ++
Sbjct: 1105 FQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIEL 1164
Query: 808 SRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLK 867
++ +E + ++ LQ E R + + VA+L QI++L+ + K ++
Sbjct: 1165 NKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD-SVAELGEQIDNLQRVKQKLEKEKS 1223
Query: 868 KYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQG-------NLSQTTQEQKQLSE 920
+++ EI L ++ K + R LE++L A+G +LS+ T ++ +L
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283
Query: 921 KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQ------ 974
+ E S Q E+ + +++ + + E+L++++ + +A LQ+
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL 1343
Query: 975 LDEYKEKNRRELAEMQRQLKEKTLEAEKSRL--------TAMKMQDEMRLMEEELRDYQR 1026
L E E+ + AE+QR L + E + R ++++ + + + L+D +
Sbjct: 1344 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEE 1403
Query: 1027 AQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDL 1086
+ K LE+T + L+ E+E + + L ++ K + L E + +
Sbjct: 1404 QVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEE 1463
Query: 1087 LSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEG 1146
+ S ++ L EL + + A ++ +++R+NK+L+ I L
Sbjct: 1464 SQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ------- 1516
Query: 1147 LVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSL 1206
+ + I ELE + E ++A++QL+ E ++ ++ L LT K ++
Sbjct: 1517 -IAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID- 1574
Query: 1207 RLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKV 1266
R++ E +EEI++L K+ QR +E M L ++ S + +RLKK
Sbjct: 1575 ------RKIAEKDEEIEQL---KRNYQRTVE---TMQSALDAEVRSRNEAIRLKKKMEGD 1622
Query: 1267 LDDMD 1271
L++++
Sbjct: 1623 LNEIE 1627
Score = 90.1 bits (222), Expect = 1e-17
Identities = 96/420 (22%), Positives = 186/420 (44%), Gaps = 70/420 (16%)
Query: 919 SEKLKEESEQKEQLRRLKNEM---ENERWHLGKTIEKLQKEMADI---VEASRTSTLELQ 972
+E KE + KE+ ++ K+E+ E +R L + + L +E D+ V+A + L+ +
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 973 NQLDEYKEKNRRELAEMQRQLKEKTLEAE-----KSRLTAMK--MQDEMRLMEEELRDYQ 1025
+ D+ + +++ ++KE T AE + LTA K ++DE +++++ D +
Sbjct: 904 ERCDQLIKAK----FQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 959
Query: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSD 1085
+ ++ E +K+L EL +R K +++ Q +L+ E + +
Sbjct: 960 LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVN 1019
Query: 1086 LLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKE 1145
L++ S+ +Q+E L + L QE+ R DLE +K LE K + I+ LE + E
Sbjct: 1020 SLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079
Query: 1146 GL---------------------------VVQMEARIAELEDRLESEERDRANLQLSNRR 1178
L + +++ARI ELE+ +E+E RA +
Sbjct: 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD 1139
Query: 1179 LERKVKELVMQVDD-----------------EHLSLTDQKDQLSLRLKAM--------KR 1213
R+++EL ++++ E L L ++ +L+ +AM
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
Query: 1214 QVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKD-LRLKKLPSKVLDDMDD 1272
V E E+ID L+ K+KL++E E + L + S+ K L+K+ + D + +
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE 1259
Score = 58.5 bits (140), Expect = 4e-08
Identities = 85/393 (21%), Positives = 167/393 (42%), Gaps = 40/393 (10%)
Query: 539 LLKGQQELTQQTNE---------ETAKQILYNYLKEGSTDND--DATKRKVNLVFEKIQT 587
+L+ Q ELTQ +E E +Q+ NY + T DA R N E I+
Sbjct: 1559 ILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRN---EAIRL 1615
Query: 588 LKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEER--- 644
K + Q ++ + + L+ + ++ + Q L ++ Q+++KE+
Sbjct: 1616 KKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV 1675
Query: 645 ER----MRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEI 700
ER ++A +EELR+ + +Q L +S ++ + + +++ +T++
Sbjct: 1676 ERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDL 1735
Query: 701 RDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQ--DLQDLLIAKEEQEDLL----- 753
LQ SE+ D A+ +E++ K A+ + + A++ QD E + L
Sbjct: 1736 MQLQ---SEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1792
Query: 754 ----RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR 809
R E E ALKG K+++ + + +L+ + + E + ESV+ K +
Sbjct: 1793 DLQHRLDEAEQLALKGG-KKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKEL 1851
Query: 810 SNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKY 869
+ SE+D+ V LQ+ +KLQ + + +R+ + Q KA+ L++
Sbjct: 1852 TYQSEEDRKN----VLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1907
Query: 870 EGEIRQLEEALVHARKEEKEAVSARRALENELE 902
E E + R + ++ S+R + E
Sbjct: 1908 EERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 176 bits (446), Expect = 1e-43
Identities = 184/761 (24%), Positives = 346/761 (45%), Gaps = 60/761 (7%)
Query: 540 LKGQQELTQQTNE--ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQ 597
L+GQ E QQ + E K L + + T + T+ K N EK+ TL A
Sbjct: 1215 LEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANA--EKLCTLYEERLHEAT 1272
Query: 598 GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ 657
T DL QK+KL E E R+L+ + + E+ +E+LR Q
Sbjct: 1273 AKLDKV--TQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQ 1330
Query: 658 HNEKVEENSTLQQRLEESEGE---LRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714
++ + S L L++++ + LR+ EE +VK E + +++ Q M E
Sbjct: 1331 LEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQW-RMKYEN 1389
Query: 715 DSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE--EVS 772
+ +R+ED E A E ++ ++ + + +A L R R + L AL + +V
Sbjct: 1390 NVIQRTEDLED-AKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVR 1448
Query: 773 SHDQEMDKLKEQYDAELQALRESVEEAT-------KNVEVLASR----SNTSEQDQAGTE 821
S +D+ + Q L ++ EE+ K V+ L++ NT E+ G E
Sbjct: 1449 SAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQE 1508
Query: 822 M---RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEE 878
K LQEE L + E + + ++++ + ++ ++ + + TL++ EG + + E
Sbjct: 1509 TLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNES 1568
Query: 879 ALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQK----QLSEKLKEESEQKEQLRR 934
++H + E + A+ LE +L + ++Q+ L L E++ + ++ R
Sbjct: 1569 KILHF---QLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTR 1625
Query: 935 LKNEMENERWHLGKTIEKLQKEMADIVEAS---RTSTLELQNQLDEYKEKNRRELAEMQR 991
LK +ME + + + +++++ ++ + +LQ QLD+ + N
Sbjct: 1626 LKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNS-------- 1677
Query: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA 1051
LKE+ AE+ +++R ++E+ +R +E +LLE T + + +
Sbjct: 1678 DLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEE-----ELLEATERINLFYTQN 1732
Query: 1052 KSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAA 1111
S L K++E V++++ E EE E+ ++ + L EL +++
Sbjct: 1733 TSLLSQK-----KKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDT 1787
Query: 1112 RQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRAN 1171
LE + ++E+ DL+ R+ E + ++E+R+ ELE LE E R A
Sbjct: 1788 IAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAE 1847
Query: 1172 LQLSNRRLERKVKELVMQVDDEHLSLT---DQKDQLSLRLKAMKRQVEEAEEEIDRLESS 1228
Q RRLER +KEL Q +++ +L+ Q D+L L+++ K+QVE AE + ++ S
Sbjct: 1848 AQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSK 1907
Query: 1229 KKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDD 1269
KK Q EL E + E + Q+N +K ++ ++ KV ++
Sbjct: 1908 YKKQQHELNEVKERAEVAESQVNKLK--IKAREFGKKVQEE 1946
Score = 137 bits (345), Expect = 7e-32
Identities = 165/746 (22%), Positives = 335/746 (44%), Gaps = 69/746 (9%)
Query: 539 LLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG 598
L+K ++E ++T E K N +E N+D +K +N + +Q +
Sbjct: 973 LVKSEKE--KRTTEHKVK----NLTEEVEFLNEDISK--LNRAAKVVQEAHQQTLDDLHM 1024
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
+ +S S+ LEQ +V EL+ L+ E K + N + E ++ NL+ R
Sbjct: 1025 EEEKLSSLSKANLKLEQ------QVDELEGALEQERKARMNCERELHKLEGNLKLNR--- 1075
Query: 659 NEKVEENSTLQQRLEESEGELRKNLEELFQV--KMERE-----QHQTEIRDLQDQLSEMH 711
E +E + Q+ L E ELRK EL Q+ K+E E Q Q +++LQ Q+ ++
Sbjct: 1076 -ESMENLESSQRHLAE---ELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLK 1131
Query: 712 DELDSAKRSE---DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK 768
++L++ + + +RE+ L ++L + L+++ + Q ++ +K+E + L ++
Sbjct: 1132 EKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDME 1191
Query: 769 EEVSSHDQEMDKLKEQYD---AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVK 825
E + LK+++ AEL+ E++++ + +E S D ++
Sbjct: 1192 EATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMT 1251
Query: 826 LLQEENEKLQGRSEE-LERRVAQLQRQIEDLKGDEAKAKETLKKYEGE-IRQLE--EALV 881
+ EKL EE L A+L + + L D A K L GE +R+LE EAL+
Sbjct: 1252 RAKANAEKLCTLYEERLHEATAKLDK-VTQLANDLAAQKTKLWSESGEFLRRLEEKEALI 1310
Query: 882 HARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN 941
+ EK + ++E +G L + T+ Q L+ L++ + LR E +
Sbjct: 1311 NQLSREKSNFT------RQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQE 1364
Query: 942 ERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAE 1001
+ L +T+ K+ EM + ++ L++ K +ELA ++ E A
Sbjct: 1365 VKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAK----KELAIRLQEAAEAMGVAN 1420
Query: 1002 KSRLTAMKMQDEMRL-MEEELRDYQRAQDEA--LTKRQLLE-QTLKDLEYELEAKSHLKD 1057
+ + + +++L + + L D + + A L ++QL + L D + + E L D
Sbjct: 1421 ARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLD 1480
Query: 1058 DRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLEC 1117
+ V+ + ++ +L+ EE + L +E++ L N++ + ++E
Sbjct: 1481 ASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEK 1540
Query: 1118 DKISLERQNKDLKSRIIHLEGSYRSSKEGLV---VQMEARIAELEDRLESEERDRANLQL 1174
K +E + +++ + EG+ ++ ++ +++ AELE +L ++ + N +
Sbjct: 1541 VKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFR- 1599
Query: 1175 SNRRLERKVKELVMQVDDEHLS----------LTDQKDQLSLRLKAMKRQVEEAEEEIDR 1224
R+ + + L +D E S + + +++ L+L RQV EA + + +
Sbjct: 1600 --RKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQ 1657
Query: 1225 LESSKKKLQRELEEQMDMNEHLQGQL 1250
L+ K LQ +L++ +N L+ Q+
Sbjct: 1658 LQIQIKDLQMQLDDSTQLNSDLKEQV 1683
Score = 127 bits (319), Expect = 7e-29
Identities = 141/664 (21%), Positives = 304/664 (45%), Gaps = 54/664 (8%)
Query: 613 LEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRL 672
L + S++ EVA L+ + K + + +RE ++A L + N+ + + Q+ L
Sbjct: 851 LVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETL 910
Query: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
E + E L + K++ E E+ + ++ E++ EL + R + E L +E+
Sbjct: 911 ANVE----EQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEI 966
Query: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
DL+ +L+ E+++ + + LT EEV ++++ KL +A
Sbjct: 967 ----DDLETMLVKSEKEKRTTEHKVKNLT-------EEVEFLNEDISKLNRAAKVVQEAH 1015
Query: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 852
++++++ E L+S S + + L+++ ++L+G E+ + +R++
Sbjct: 1016 QQTLDDLHMEEEKLSSLSKANLK-----------LEQQVDELEGALEQERKARMNCEREL 1064
Query: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 912
L+G+ +E+++ E R L E L RK+E E +ENE +G ++Q
Sbjct: 1065 HKLEGNLKLNRESMENLESSQRHLAEEL---RKKELELSQMNSKVENE----KGLVAQLQ 1117
Query: 913 QEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQ 972
+ K+L ++K+ E+ E R + +ME ER L + + L + + ++ +S
Sbjct: 1118 KTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQL---- 1173
Query: 973 NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ-DEMRLMEEELRDYQRAQDEA 1031
E +K + ++ R ++E TL E + + K D + +E ++ + Q+ + +
Sbjct: 1174 ----EITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKL 1229
Query: 1032 LTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE-ERNNSDLLSER 1090
+ L+ + DL +E + K + +L E+++ + +L++ + +DL +++
Sbjct: 1230 EKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQK 1289
Query: 1091 ISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQ 1150
E E LR L ++ A L +K + RQ +DL+ + + E +S+ + +
Sbjct: 1290 TKLWSESGEFLR-RLEEKEALINQLSREKSNFTRQIEDLRGQ-LEKETKSQSALAHALQK 1347
Query: 1151 MEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL----SLTDQKDQLSL 1206
+ L ++ E E+ +A L + ++ ++ + M+ ++ + L D K +L++
Sbjct: 1348 AQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAI 1407
Query: 1207 RLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPS-K 1265
RL+ + A LE ++ +LQ EL + + G++ S L K+L S K
Sbjct: 1408 RLQEAAEAMGVANARNASLERARHQLQLELGDALSD----LGKVRSAAARLDQKQLQSGK 1463
Query: 1266 VLDD 1269
L D
Sbjct: 1464 ALAD 1467
Score = 67.8 bits (164), Expect = 7e-11
Identities = 63/318 (19%), Positives = 146/318 (45%), Gaps = 32/318 (10%)
Query: 983 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDE-------MRLMEEELRDYQRAQDEALTKR 1035
+ E A++Q+ L++ + E+ + + + E ++ +E L + + + + +
Sbjct: 865 KEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSK 924
Query: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE-------ERNNSDLLS 1088
LE +K+L +E + + + + +++ED+ +L+ E+++
Sbjct: 925 IQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTE 984
Query: 1089 ERISRSREQMEQLRNELLQ-ERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
++ E++E L ++ + RAA+ E + +L+ +H+E SS
Sbjct: 985 HKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD---------LHMEEEKLSSLSKA 1035
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVK---ELVMQVDDEHLSLTDQKDQL 1204
+++E ++ ELE LE E + R N + +LE +K E + ++ L ++ +
Sbjct: 1036 NLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Query: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPS 1264
L L M +VE + + +L+ + K+LQ +++ D+ E L+ + + K R + +
Sbjct: 1096 ELELSQMNSKVENEKGLVAQLQKTVKELQTQIK---DLKEKLEAERTTRAKMERERADLT 1152
Query: 1265 KVLDDMDDDDDLSTDGGS 1282
+ L D+ ++ L GGS
Sbjct: 1153 QDLADL--NERLEEVGGS 1168
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 170 bits (431), Expect = 7e-42
Identities = 221/895 (24%), Positives = 390/895 (43%), Gaps = 185/895 (20%)
Query: 532 NTQATPDLLKGQQELTQQTNEETA--KQILYNYLKEGSTDNDDATKRKVN------LVFE 583
+T+ L+G +LTQ++ + A KQ L LK+ ++ + R + + +
Sbjct: 1096 DTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQK 1155
Query: 584 KIQTLKSRA-----------AGSAQGNNQACNSTSEVKDLLEQKS--------------K 618
KI+ L++RA A A+ Q + E+++L E+ K
Sbjct: 1156 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 1215
Query: 619 LTIEVAELQRQLQ-LEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEG 677
E+ L+R+L+ ++++ + R + EL E+V+ ++Q+LE+ +
Sbjct: 1216 REAELGRLRRELEEAALRHEATVAALRRKQAEGAAEL----GEQVDSLQRVRQKLEKEKS 1271
Query: 678 ELRK-------NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS---EDREKGA 727
ELR N+E L + K E+ R +DQLSE +++ +R ++G
Sbjct: 1272 ELRMEVDDLAANVETLTRAKASAEKL---CRTYEDQLSEAKIKVEELQRQLADASTQRGR 1328
Query: 728 L------IEELLQAKQDLQDLL-----IAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 776
L + LL+ K+ L L +A + E+L R+ E E A K AL V +
Sbjct: 1329 LQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKA-KSALAHAVQALRH 1387
Query: 777 EMDKLKEQYDAELQALRESVEEATK-NVEVLASRSN--------TSEQDQAGTEMRVKLL 827
+ D L+EQ++ E +A E +K N EV RS T E ++A ++ ++L
Sbjct: 1388 DCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQ 1447
Query: 828 QEEN--EKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARK 885
+ E E + LE+ +LQ + ED+ + +A + + R LE AL R+
Sbjct: 1448 EAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRR 1507
Query: 886 EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945
+E+E ++ ELEAAQ E +L +E E E L+R ++ E
Sbjct: 1508 QEEE-------MQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISD 1560
Query: 946 L-------GKTIEKLQK-----------------EMADIVEASRTSTLELQNQLDEYKEK 981
L GK+I++L+K E +E T TL +Q +L + K +
Sbjct: 1561 LTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAE 1620
Query: 982 NRR-------ELAEMQRQLK------EKTLEAE-KSRLTAMKMQDEM------------- 1014
R E A ++R + + +L+AE ++R A++++ +M
Sbjct: 1621 VDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGH 1680
Query: 1015 ------------RLMEEELRDYQRAQDE-------------ALTKR-QLLEQTLKDLEYE 1048
RLM+ +L++ Q +DE AL +R LL L++L
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAA 1740
Query: 1049 LE--------AKSHLKDDRSRL-------------VKQMEDKVSQLEMELEEERNNSDLL 1087
LE A+ L + RL K++E ++QL E+EE
Sbjct: 1741 LEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREA 1800
Query: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
E+ ++ + EL +E+ LE K +LE+ ++L++R+ E + +
Sbjct: 1801 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQ 1860
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT---DQKDQL 1204
V ++EA++ ELE L++E++ A R+ ER+VKEL Q +++ +L D D+L
Sbjct: 1861 VQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKL 1920
Query: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQREL---EEQMDMNEHLQGQLNSMKKD 1256
++K+ KRQ EEAE++ + + +K Q EL EE+ DM E +L + +D
Sbjct: 1921 QSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975
Score = 149 bits (377), Expect = 1e-35
Identities = 172/779 (22%), Positives = 340/779 (43%), Gaps = 90/779 (11%)
Query: 553 ETAKQILYNYLKEGSTDNDDATKRKVNLVFEK--IQTLKSRAAGSAQGNNQACNSTSEVK 610
E KQ N +K + + + L EK +Q +A G Q ++ ++ K
Sbjct: 1014 EKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAK 1073
Query: 611 DLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQ 670
LEQ +V +L+ L+ E K + + + + ++ +L+ + + ++ L++
Sbjct: 1074 LRLEQ------QVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE 1127
Query: 671 RLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELD---SAKRSEDREKGA 727
+L++ + EL + + ++ Q Q +I++LQ + E+ +EL+ +A+ ++++
Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187
Query: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLK----- 782
EL + + L++ A Q + RKRE EL L+ L+E H+ + L+
Sbjct: 1188 AARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAE 1247
Query: 783 ------EQYDAELQALRESVE----EATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
EQ D+ LQ +R+ +E E V+ LA+ T + +A E + +++
Sbjct: 1248 GAAELGEQVDS-LQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLS 1306
Query: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
+ + + EEL+R++A Q L+ + + L++ E I QL A + +E
Sbjct: 1307 EAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE--- 1363
Query: 893 ARRALENELEAAQGNLSQTTQEQKQ----LSEKLKEESEQKEQLRRL--KNEMENERWHL 946
RR LE E A+ L+ Q + L E+ +EE+E + +L+RL K E +W
Sbjct: 1364 LRRQLEEE-SKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS 1422
Query: 947 GKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKN------RRELAEMQRQLKEKTLEA 1000
+ +Q+ ++ EA + L LQ + + N + +Q + ++ TLE
Sbjct: 1423 KYEADAIQR-TEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLEL 1481
Query: 1001 EKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDL-----------EYEL 1049
E++ A + + R +E L + +R ++E + + ++ + L E L
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541
Query: 1050 EAKSHLKDDRSRL------------------------VKQMEDKVSQLEMELEEERNNSD 1085
EA LK + L K +E + S+++ LEE +
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1601
Query: 1086 LLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKE 1145
L + R + ++ Q++ E + + A +D EC + Q + ++S L+ R+ E
Sbjct: 1602 LEETKTLRIQLELSQVKAE-VDRKLAEKDEECANLRRNHQ-RAVESLQASLDAETRARNE 1659
Query: 1146 GLVV--QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEH---LSLTDQ 1200
L + +ME + +LE +L R Q + R ++ ++KE D+E L +Q
Sbjct: 1660 ALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQ 1719
Query: 1201 KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMD----MNEHLQGQLNSMKK 1255
L R + ++EE +++ E S++ ++EL E + ++ G LN KK
Sbjct: 1720 AQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKK 1778
Score = 132 bits (332), Expect = 2e-30
Identities = 159/711 (22%), Positives = 314/711 (44%), Gaps = 91/711 (12%)
Query: 610 KDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEE-------RERMRANLEELRSQHNEKV 662
++L E +T E +L QLQ E N + +E + ++ ++EL + ++
Sbjct: 920 QELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEE 979
Query: 663 EENSTL---QQRLEESEGELRKNLEEL--FQVKMEREQHQTE--IRDLQDQLSEMHDELD 715
E N+ L +++LE+ EL+K++++L K E+E+ TE +++L ++++ LD
Sbjct: 980 EVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAA----LD 1035
Query: 716 SAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKR----ERELTALKGALKEEV 771
+ +EK AL E QA DLQ A+E++ L K E+++ L+ +L++E
Sbjct: 1036 ESVARLTKEKKALQEAHQQALGDLQ----AEEDRVSALTKAKLRLEQQVEDLECSLEQEK 1091
Query: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN 831
+ ++ K + + +L+ +ESV +A ++ + L + + + + +RV+ Q
Sbjct: 1092 KLR-MDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLG 1150
Query: 832 EKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA-------- 883
++Q + +EL+ R +L+ ++E + A+ ++ + E+ +L E L A
Sbjct: 1151 AQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQR 1210
Query: 884 ---RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEME 940
RK E E RR LE EAA + + +++ +E E EQ + L+R++ ++E
Sbjct: 1211 EGCRKREAELGRLRRELE---EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLE 1267
Query: 941 NERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEA 1000
E+ L ++ L + + A + A
Sbjct: 1268 KEKSELRMEVDDLAANVETLTRAKAS---------------------------------A 1294
Query: 1001 EKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060
EK T E ++ EEL QR +A T+R L+ +L LE K L S
Sbjct: 1295 EKLCRTYEDQLSEAKIKVEEL---QRQLADASTQRGRLQTESGELSRLLEEKECLISQLS 1351
Query: 1061 RLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKI 1120
R + +L +LEEE L+ + R + LR + +E A+ +L+
Sbjct: 1352 RGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQ---R 1408
Query: 1121 SLERQNKDLKSRIIHLEGSYRSSKEGL---VVQMEARIAELEDRLESEERDRANLQLSNR 1177
L + N ++ E E L ++ R+ E E+ +E+ ++L+ +
Sbjct: 1409 LLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKL 1468
Query: 1178 RLERKVKELVMQVD---DEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQR 1234
RL+ + +++ ++++ +L ++ L L+ +RQ EE + E++ + + L
Sbjct: 1469 RLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGT 1528
Query: 1235 ELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYE 1285
EL +E L ++K++ K L ++ D D +S G S+ E
Sbjct: 1529 ELFRLRHGHEEALEALETLKRE--NKNLQEEI---SDLTDQVSLSGKSIQE 1574
Score = 130 bits (326), Expect = 1e-29
Identities = 173/773 (22%), Positives = 322/773 (41%), Gaps = 100/773 (12%)
Query: 572 DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVK-DLLEQKSKLTIEVAELQRQ- 629
DA +R L+ K+Q G + ++ EV DL ++ KL E EL++
Sbjct: 949 DAEERCHLLIKSKVQL-----EGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDI 1003
Query: 630 --LQLEVKNQQNIKEERERMRANLEELRSQHNEKV----EENSTLQQRLEESEGELRKNL 683
L+L + + K+ E NL E + +E V +E LQ+ +++ G+L+
Sbjct: 1004 DDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEE 1063
Query: 684 EELFQVKMEREQHQTEIRDLQ---DQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQ 740
+ + + + + + ++ DL+ +Q ++ + + AKR + + E + A QD Q
Sbjct: 1064 DRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQ 1123
Query: 741 DL-------------LIAKEEQEDLL----RKRERELTALKGALKEEVSSH--------- 774
L L + E E LL +K+ +EL A L+EE+ +
Sbjct: 1124 QLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEK 1183
Query: 775 -----DQEMDKLKEQY-----------------DAELQALRESVEEAT-KNVEVLASRSN 811
+E+++L E+ +AEL LR +EEA ++ +A+
Sbjct: 1184 QRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRR 1243
Query: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871
+ A +V LQ +KL+ EL V L +E L +A A++ + YE
Sbjct: 1244 KQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYED 1303
Query: 872 EIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQK----QLSEKLKEESE 927
++ + + + +++ +A + R L+ E G LS+ +E++ QLS ++
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTE----SGELSRLLEEKECLISQLSRGKALAAQ 1359
Query: 928 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA 987
E+LRR E + L ++ L+ + D++ E Q +L K E+A
Sbjct: 1360 SLEELRRQLEEESKAKSALAHAVQALRHD-CDLLREQHEEEAEAQAELQRLLSKANAEVA 1418
Query: 988 EMQRQLKEKTLEAEKSRLTAMKMQDEMRLME-EELRDYQRAQDEALTKRQLLEQT-LKDL 1045
+ + + + ++ L K + +RL E EE + A+ +L K +L QT +D+
Sbjct: 1419 QWRSKYEADAIQ-RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 1477
Query: 1046 EYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNEL 1105
ELE + ++ K LE LEE R + + + ++ + L EL
Sbjct: 1478 TLELER-------ATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTEL 1530
Query: 1106 LQERAARQDLECDKISLERQNKDLKSRI------IHLEG-------SYRSSKEGLVVQME 1152
+ R ++ +L+R+NK+L+ I + L G + + EG +++
Sbjct: 1531 FRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ 1590
Query: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMK 1212
A + E E LE EE +QL +++ +V + + D+E +L + L+A
Sbjct: 1591 AALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASL 1650
Query: 1213 RQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSK 1265
A E RL KKK++ +L + H Q + RL + K
Sbjct: 1651 DAETRARNEALRL---KKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLK 1700
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 155 bits (393), Expect = 2e-37
Identities = 154/710 (21%), Positives = 325/710 (45%), Gaps = 92/710 (12%)
Query: 607 SEVKDLLEQKSKLTIEVAELQRQLQLEVKNQ----QNIKEER---ERMRANLEELRSQHN 659
S+ + L ++K KLT E+ +LQ+ +++ +N+ Q +KE + RA LE+L+SQ
Sbjct: 1531 SDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVT 1590
Query: 660 EKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQ--------------HQTEIRDLQD 705
+ +E + L ++L + EL + Q K + ++ H E++ L +
Sbjct: 1591 SQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
Query: 706 QLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLL--IAKEEQE-----DLLRKRER 758
+LS EL+ + + +E+ + +++LQ +L ++K + E D+L+
Sbjct: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENH 1710
Query: 759 ELTALKGALKEEVSSHD-------------QEMDKLKEQYDAELQALRESVEEATKNVEV 805
EL LK + VS + + + ++ +Q E++ ++ +E + +E
Sbjct: 1711 ELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIER 1770
Query: 806 LASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKET 865
+ + S + V+ L +E E LQ + + E+++AQ +R + + + +
Sbjct: 1771 MTAESRALQSC-------VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
Query: 866 LKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEE 925
L+K E +R+L++ L ++ + +L N++ A Q L + + L E+L
Sbjct: 1824 LEKLELNVRKLQQELDQLNRD-------KLSLHNDISAMQQQLQEKREAVNSLQEELANV 1876
Query: 926 SE-----QKEQLRRLKNE--MENERWHLGKTIEKLQKEMADIVEASRTSTLELQ---NQL 975
+ +++ L K++ + +E+ L K I + D + T +LQ N++
Sbjct: 1877 QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1936
Query: 976 DEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKR 1035
+E K K ++ QR KE+ E K + + ++++ +E+EL D + D+ L+K
Sbjct: 1937 EENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKV 1996
Query: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
E+ ++ L+ E + + + Q + ++S+ E +L E+ L + R
Sbjct: 1997 LAAEERVRTLQEE----ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMR 2052
Query: 1096 EQMEQLRNELLQER-AARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEAR 1154
LRN+ L ER A + + K +L+ Q L+ ++ +E +Q E
Sbjct: 2053 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLL------EQKQENSCIQKEMA 2106
Query: 1155 IAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKD------QLSLRL 1208
EL + + +RA RRL +++ ++ + + + +QKD ++S +
Sbjct: 2107 TIEL---VAQDNHERA------RRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAM 2157
Query: 1209 KAMKRQV-EEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
+ +K +V +E + L +L +LE ++ NE+L+G+L S+K++L
Sbjct: 2158 RTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENL 2207
Score = 120 bits (302), Expect = 6e-27
Identities = 164/713 (23%), Positives = 303/713 (42%), Gaps = 143/713 (20%)
Query: 601 QACNSTSEVKDLLE----QKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRA------- 649
+ CN EVK LLE QK +L ++++E + QL L +Q I++E E ++
Sbjct: 1637 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLI---KQEIEKEEENLQVVLRQMSK 1693
Query: 650 -----------------NLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKME 692
L+ L+ QH+++V E Q + E + EL +NL+++ Q
Sbjct: 1694 HKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL-ENLQQISQ---- 1748
Query: 693 REQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQD----------- 741
Q + EI + Q QL E +E R + +E L + K+DLQ+
Sbjct: 1749 --QQKGEI-EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQ 1805
Query: 742 ---LLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA---ELQALRES 795
+L A EE + + +L L++E+ +++ L A +LQ RE+
Sbjct: 1806 TKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREA 1865
Query: 796 VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDL 855
V + + + N ++QD T +L E +LQ + +++ + ED
Sbjct: 1866 VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ-------KDISEWANRFEDC 1918
Query: 856 KGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQ 915
+ +E ++ L+ + EI + + LV + R + E++LE ++ L ++Q
Sbjct: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK---EQQ 1975
Query: 916 KQLSEKLKEESEQKEQL--------RRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 967
QL ++L ++ + +Q+ R++ E ERW E L+K ++
Sbjct: 1976 HQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERW-----CESLEKTLS--------- 2021
Query: 968 TLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRA 1027
+ +R+L+E ++QL EK+ E L K D MR D+
Sbjct: 2022 -------------QTKRQLSEREQQLVEKSGEL----LALQKEADSMR------ADFSLL 2058
Query: 1028 QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQM-----EDKVSQLEM-ELEEER 1081
+++ LT+R+ E+ + L K LK RS+L K + E+ Q EM +E
Sbjct: 2059 RNQFLTERKKAEKQVASL------KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVA 2112
Query: 1082 NNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYR 1141
++ + R+ + QM+ EL ++ A ++DLE ++ + + LKS + + R
Sbjct: 2113 QDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEV---KDEIR 2169
Query: 1142 SSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL---------ERKVKELVMQVDD 1192
+S + L + A+LE LE E L+ L E K+ + + D
Sbjct: 2170 TSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMD 2229
Query: 1193 EHL-------SLTDQKDQLSLRLK-AMKRQVEEAEEEIDRLESSKKKLQRELE 1237
EH L ++D+L +L+ M +Q E + + E + L+R+++
Sbjct: 2230 EHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVD 2282
Score = 117 bits (293), Expect = 7e-26
Identities = 144/728 (19%), Positives = 317/728 (43%), Gaps = 106/728 (14%)
Query: 625 ELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLE 684
++ + L+ + + ++ ++ + + +EEL ++ ++E +L+ +EE ++K +
Sbjct: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQ 1389
Query: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDS---------AKRSEDREKGALIEE---- 731
+ + E TE+ +++ L D +D +RSE RE L+ E
Sbjct: 1390 QKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESE 1448
Query: 732 ---------------------LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEE 770
LLQ + D ++L +E L K +++L +L+ K +
Sbjct: 1449 LSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAK-D 1507
Query: 771 VSSHD-------QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMR 823
+ H +E++K+ D++ Q L + E+ T+ ++ L +E+++ +
Sbjct: 1508 LEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNE---DHH 1564
Query: 824 VKLLQEENEKLQGRSEELER---RVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQ----L 876
+++L+E LQ + ELE+ +V Q+++ L KE L +G + Q L
Sbjct: 1565 LQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADL 1624
Query: 877 EEALVHARKEEKEA---VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ-L 932
+EAL E E + ++L EL +G L+ E+K +K+E E++E+ L
Sbjct: 1625 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684
Query: 933 RRLKNEMENERWHLGKTIEKLQKEMADI-------------VEASRTSTLELQNQLDEYK 979
+ + +M + L ++ LQ E ++ +E ++ + LE + +L+ +
Sbjct: 1685 QVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQ 1744
Query: 980 EKNRRELAEM--QRQLKEKTLEAEKSRLTAMK----------------MQDEMRLMEEEL 1021
+ ++++ E+ Q+QL E+ + E R+TA +Q++ + E++L
Sbjct: 1745 QISQQQKGEIEWQKQLLERD-KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKL 1803
Query: 1022 RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER 1081
+R A ++ + L+ LE + D +R + + +S ++ +L+E+R
Sbjct: 1804 AQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
Query: 1082 NNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYR 1141
+ L E ++ ++ + + +LL + L ++ L++ + +R +
Sbjct: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
Query: 1142 SSKEGL-------------VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVM 1188
+ ++ L +VQ E L+ ESEE + L+ S L+ + +L
Sbjct: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE---SKLETSKVTLKEQQHQLEK 1980
Query: 1189 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248
++ D+ L DQ L + R ++E E + LE + + +R+L E+ G
Sbjct: 1981 ELTDQKSKL-DQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG 2039
Query: 1249 QLNSMKKD 1256
+L +++K+
Sbjct: 2040 ELLALQKE 2047
Score = 113 bits (283), Expect = 1e-24
Identities = 138/616 (22%), Positives = 286/616 (46%), Gaps = 61/616 (9%)
Query: 662 VEENSTLQQRLEESEGELRK---NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAK 718
++ +Q + E + +LR NL + + E + +I Q +LSE+HDE++ A+
Sbjct: 405 IDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAE 464
Query: 719 RSEDR--EKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 776
+ R E+ +EE +Q K+ E +DLL K+ L L++E +
Sbjct: 465 QQILRATEEFKQLEEAIQLKK-------ISEAGKDLLYKQLSGRLQLVNKLRQEALDLEL 517
Query: 777 EMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQG 836
+M+K K++ + + +++ ++ A +++ + + + ++G E ++ ++ ++ ++L+
Sbjct: 518 QMEKQKQEIAGKQKEIKD-LQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLES 576
Query: 837 RSEELERRVAQLQRQIEDLKGD----EAKAKETLKK-YEGEIRQLEEALVHARKEEKEAV 891
R +E+ R+A+ +I+DL+ + A E LKK EG I L+E L + + +A
Sbjct: 577 RLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQ 636
Query: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIE 951
+ R L +E E L++ QE+ QL + +++L L++ ++ E+ + +++
Sbjct: 637 NECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQ-EQHEVNASLQ 695
Query: 952 KLQKEMADIVEASRTSTLELQ----NQLDEYKEKNRR----ELAEMQRQLKEKTLEAEKS 1003
+ Q +++ EA + L L+ NQL E EK R E + +Q +L EK +A K+
Sbjct: 696 QTQGDLS-AYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAEL-EKERQALKN 753
Query: 1004 RLTAMKMQDEMRLMEEELR-DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRL 1062
L + +E EL + QD+ LL+Q LKD + L +H+ D R
Sbjct: 754 ALGKAQFSEEKEQENSELHAKLKHLQDD----NNLLKQQLKDFQNHL---NHVVDGLVR- 805
Query: 1063 VKQMEDKVSQL--EMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKI 1120
+++ +V +L +++L N S+ + +S +++ +E+L AR E D+
Sbjct: 806 PEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEIL----ARSKWERDEA 861
Query: 1121 SLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERD-RANLQLSNRRL 1179
+ R +E + +Q E E+ ++ ER A + R+
Sbjct: 862 QVRE----------------RKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQH 905
Query: 1180 ERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
E +++++ ++ +L ++ L ++ EE E + +L +KK + E +
Sbjct: 906 EARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKS 965
Query: 1240 MDMNEHLQGQLNSMKK 1255
+ L +L +KK
Sbjct: 966 QEQVFGLDKELKKLKK 981
Score = 112 bits (279), Expect = 3e-24
Identities = 139/650 (21%), Positives = 280/650 (43%), Gaps = 50/650 (7%)
Query: 630 LQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQV 689
L V N++ E R+ ++ L+S+ E+ ++ +Q +E E EL N+++L Q
Sbjct: 1311 LHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQE 1369
Query: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749
K E E+ + + D +D S E IE+ L+ +D+ D + E+
Sbjct: 1370 KKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--IEKSLKHHEDIVDEIECIEKT 1427
Query: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQY-DAELQALR--ESVEEATKNVEVL 806
R RE L + E+S ++ E++ DA+ L+ EE + +
Sbjct: 1428 LLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET 1487
Query: 807 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETL 866
A ++Q + K L++ K + +E+ + VA + L + K E L
Sbjct: 1488 AVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL 1547
Query: 867 KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
+K + +I E H + KE+ +A ELE + SQ T +Q++++ ++
Sbjct: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLK---SQVTSQQQEMAVLDRQLG 1604
Query: 927 EQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE-KNRRE 985
+KE+L L+ M + AD+ EA R E+ + + +E K+ E
Sbjct: 1605 HKKEELHLLQGSMVQAK--------------ADLQEALRLGETEVTEKCNHIREVKSLLE 1650
Query: 986 LAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDL 1045
Q+ + K++LT +K + E EE L+ R + T+ + + L+
Sbjct: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEKE--EENLQVVLRQMSKHKTELKNILDMLQLE 1708
Query: 1046 EYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNEL 1105
+EL+ D R +++ + V + ++ELE + S I ++ +E+ + E+
Sbjct: 1709 NHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREI 1768
Query: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
+ A + L+ L ++ +DL+ + E + Q + +A E+ + E
Sbjct: 1769 ERMTAESRALQSCVECLSKEKEDLQEKC--------DIWEKKLAQTKRVLAAAEENSKME 1820
Query: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLR--LKAMKRQVEEAEEEID 1223
+ + L+L+ R+L++++ +L +D+LSL + AM++Q++E E ++
Sbjct: 1821 QSNLEKLELNVRKLQQELDQL-------------NRDKLSLHNDISAMQQQLQEKREAVN 1867
Query: 1224 RLESSKKKLQRELE-EQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDD 1272
L+ +Q L + D+ + Q + + RL+K S+ + +D
Sbjct: 1868 SLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 1917
Score = 98.6 bits (244), Expect = 3e-20
Identities = 173/821 (21%), Positives = 360/821 (43%), Gaps = 145/821 (17%)
Query: 560 YNYLKEGSTDNDDATKRKVNLVFEKIQ--------TLKSRAAGSAQGNN-QACNSTSEVK 610
YN + + + +K+NL +I+ LKS + +GN + S++K
Sbjct: 156 YNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLK 215
Query: 611 DLLEQKSKLTIE--VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTL 668
L + S + +E V L LQ + +L L S + V T
Sbjct: 216 PLQDLISLILVENPVVTLPHYLQFTI--------------FHLRSLESLEGQPV----TT 257
Query: 669 QQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL 728
Q R E E R +LEE+ +++ + E+ E +L+ + + +E+ +++D+ +L
Sbjct: 258 QDRQEAFE---RFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI----KNQDKLNKSL 310
Query: 729 IEELLQAKQDLQDLLIAKEEQEDLLRKRERELTAL---KGALKEEVSSH--DQEMDKLKE 783
EE + KQ ++L + +LL+++ ELT + L++E++ + D + + L
Sbjct: 311 KEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLN- 369
Query: 784 QYDAELQALRESVEEATK------NVEVLASRSNTSEQDQAGTEMRVK---LLQEENEKL 834
Y +E + ++ +E+ + A+ S + QA +++ L+ ++ L
Sbjct: 370 YYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNL 429
Query: 835 QGRS------EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK 888
+G + E+ E++++ Q ++ +L + KA++ + + E +QLEEA+ + E
Sbjct: 430 RGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEA 489
Query: 889 ------EAVSARRALENELEAAQGNLSQTTQEQKQ-LSEKLKE----------------- 924
+ +S R L N+L +L ++QKQ ++ K KE
Sbjct: 490 GKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPK 549
Query: 925 -------ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI-----------VEASRT 966
+S +++QL + + + L + + ++ KE +I + A+
Sbjct: 550 HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEA 609
Query: 967 STLELQ---NQLDEY----------KEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE 1013
+L+ + L EY + R+L + + L ++ E E+ R + +
Sbjct: 610 LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMD 669
Query: 1014 MRLMEEELRDYQRAQDEALTKRQLLEQTLKDL---EYELEAKSHLKDDRSRLVKQMEDKV 1070
M +EL + + A E L+QT DL E ELEA+ +L+D + +K+ +KV
Sbjct: 670 AENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV 729
Query: 1071 --------SQLEMELEEERNNSDLLSERISRSR--EQMEQLRNELLQERAARQDLECDKI 1120
S L+ ELE+ER L + +++ E+ EQ +EL A + L+ D
Sbjct: 730 TRLTQLEQSALQAELEKER---QALKNALGKAQFSEEKEQENSEL---HAKLKHLQDDNN 783
Query: 1121 SLERQNKDLKSRIIHLEGSYRSSKEGLV--VQMEARIAELEDRLESEERDRANLQLSNRR 1178
L++Q KD ++ + H+ +GLV ++ AR+ EL +L+ + N+ +
Sbjct: 784 LLKQQLKDFQNHLNHV-------VDGLVRPEEVAARVDELRRKLKLGTGE-MNIHSPSDV 835
Query: 1179 LERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI-DRLESSKKKLQRELE 1237
L + + +L Q + ++D+ +R + ++ ++ +E++ E ++ +R LE
Sbjct: 836 LGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALE 895
Query: 1238 EQM--DMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDL 1276
+M D +H + ++ M+ ++ + K ++++ DL
Sbjct: 896 ARMNFDKRQH-EARIQQMENEIHYLQENLKSMEEIQGLTDL 935
Score = 95.5 bits (236), Expect = 3e-19
Identities = 139/592 (23%), Positives = 260/592 (43%), Gaps = 94/592 (15%)
Query: 588 LKSRAAGSAQG----NNQACNSTSEVKDLLEQKSKLTIEVAELQRQL-QLEVKNQQNIKE 642
+K++ +G Q N Q S + ++L + +K T E+ +L+ QL + ++ + +K+
Sbjct: 553 MKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK 612
Query: 643 ERERMRANLEEL-----------RSQHNEKVEENSTLQQRLEESEGE------------- 678
+ E + + L+E +++ + +E TL QRL E E E
Sbjct: 613 DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAEN 672
Query: 679 LRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQD 738
+RK L EL E+ + ++ Q LS EL++ D E L EEL + +
Sbjct: 673 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTR- 731
Query: 739 LQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMD------KLKEQYDAELQAL 792
+ + EQ L + E+E ALK AL + S ++E + KLK D + L
Sbjct: 732 -----LTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD-DNNLL 785
Query: 793 RESVEEATKNVEVLASRSNTSEQDQAGT-EMRVKLLQEENE-KLQGRSEELERRVAQLQR 850
++ +++ ++ + E+ A E+R KL E + S+ L + +A LQ+
Sbjct: 786 KQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQK 845
Query: 851 QIEDL------KGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEA----VSAR------ 894
Q ++ + DEA+ +E +K + E+ +E L ++E ++A + AR
Sbjct: 846 QFSEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKR 903
Query: 895 ------RALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE----QLRRL--KNEMENE 942
+ +ENE+ Q NL + Q +L+E E+KE QLR L K ++E+
Sbjct: 904 QHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDA 963
Query: 943 R-----WHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 997
+ + L K ++KL+K +A + + +T EL D+ K + + ++ ++ E+
Sbjct: 964 KSQEQVFGLDKELKKLKKAVA---TSDKLATAELTIAKDQLKSLH-GTVMKINQERAEEL 1019
Query: 998 LEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD 1057
EAE+ R + RD RA+ E + LL Q + E+E K+ +
Sbjct: 1020 QEAERF----------SRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEME-KTGVGT 1068
Query: 1058 DRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQER 1109
+ V ++E +E + E ++L S ++ E + E+ + R
Sbjct: 1069 GANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELR 1120
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 153 bits (387), Expect = 9e-37
Identities = 178/781 (22%), Positives = 352/781 (45%), Gaps = 86/781 (11%)
Query: 541 KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNN 600
KG + E+ ++ L ++G + + + + VF++ + + R +
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKE 256
Query: 601 QACNSTSEV---KDLLEQKSKLT-IEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS 656
+ E ++L E++ +L +E EL+R+ Q E + QQ ++ E++ R EE R
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE 316
Query: 657 QHNEKVEENSTLQQRLEESEGELRKNLEELF--QVKMEREQHQTEIRDLQDQLSEMHDEL 714
Q E+ E+ +Q+ E E +LR+ EE Q++ E+E+ + E + ++Q E ++
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 715 DSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
++ RE+ E+ L+ +Q L+ +E+Q +RE++L + +E+
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLR-----REQQ----LRREQQLRREQQLRREQQLRR 427
Query: 775 DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEK- 833
+QE ++ +++++ E + R E+ + + L T +Q + ++K QEE +
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERR-DWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 834 ------LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEE 887
+ R E+ ERR QL+R+ E+ + K +E ++ + +R E + +EE
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR--SEQQLRREQEE 544
Query: 888 KEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN--ERWH 945
+ +R E LE + +++++ + LK E E+++Q RLK E E E+
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ--RLKREQEERLEQRL 602
Query: 946 LGKTIEKLQKEMADIVEASRTSTLELQNQ----LDEYKEKNRRELAEMQRQLKEKTL--E 999
+ +E+L++E R E + Q +E +E+ +++L Q++ +E+ L E
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHL---- 1055
E+ RL Q R EEE R+ + A++E R+ ++ + +++LE+++
Sbjct: 663 EEEERLE----QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 1056 ------KDDRSRLVKQMEDKVSQLEMEL---EEERNNSDLLSERISRS------------ 1094
K + R ++ E+K + E EL EEER + E R
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 1095 ------------REQME-QLRNELLQERAAR-QDLECDKISLERQNKDLKSRIIHLEGSY 1140
REQ E QLR E Q+R R E +K RQ ++ + + LE
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE--- 835
Query: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ 1200
E +Q R +L++ + + D+ + +R ++K + + +
Sbjct: 836 ----EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 1201 KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
K L +L+ ++ ++E EEE+ R E K++ Q E E Q E LQ + + ++ R K
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQ-EQERQYREEEQLQQEEEQLLREEREK 950
Query: 1261 K 1261
+
Sbjct: 951 R 951
Score = 146 bits (369), Expect = 1e-34
Identities = 161/667 (24%), Positives = 312/667 (46%), Gaps = 52/667 (7%)
Query: 592 AAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQ-RQLQLEVKNQQNIKEERERMRAN 650
A G A G ++ + + K+ L Q + + + R QLE + Q +++R+
Sbjct: 88 ALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERE 147
Query: 651 LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQT----EIRDLQDQ 706
L E Q ++ +QR +E R+ +E + + E EQ Q+ E + D+
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207
Query: 707 LSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGA 766
++L + E R KG EE Q +++ QD + +EE+++ RKRE L +
Sbjct: 208 -----EQLRRRELLELRRKGR--EEKQQQRRERQDRVFQEEEEKE-WRKRETVLRKEEEK 259
Query: 767 LKEEVSSHDQEMDKLKEQY-DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVK 825
L+EE +E+ + +EQ E Q LR +E + + L ++R K
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ----------QLRRK 309
Query: 826 LLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARK 885
+E E+ + R E+ ERR Q +R+ + L+ ++ + +E + E E + E+ L ++
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369
Query: 886 EEKEAVSARRALENELEAAQGNLSQTTQEQK-QLSEKLKEESE--QKEQLRR---LKNEM 939
EE+ RR + E Q +EQ+ + ++L+ E + +++QLRR L+ E
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
E ER H K ++ +++ + R L+ + + + ++++ R++ QLK E
Sbjct: 430 EEER-HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ------QLKRDQEE 482
Query: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
+ R +K+++E R ++E R+ Q +++ + EQ LK E E + L+ ++
Sbjct: 483 ERRERW--LKLEEEERREQQERREQQLRREQ----EERREQRLKRQEEEERLQQRLRSEQ 536
Query: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDK 1119
+L ++ E++ QL EE+R + +R+ R + E+ R++LL+ R+ +
Sbjct: 537 -QLRREQEERREQLLKREEEKRLEQERREQRLKR---EQEERRDQLLKREEERRQQRLKR 592
Query: 1120 ISLERQNKDLK-SRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER-DRANLQLSNR 1177
ER + LK + LE R +E + + E + L+SEE+ +R QL
Sbjct: 593 EQEERLEQRLKREEVERLEQEER--REQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 1178 RLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237
+ ER+ + L + ++E L +++ R + + EE E+ +R++S K Q +LE
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEER-REQELAEEEQEQARERIKSRIPKWQWQLE 709
Query: 1238 EQMDMNE 1244
+ D +
Sbjct: 710 SEADARQ 716
Score = 145 bits (365), Expect = 3e-34
Identities = 166/781 (21%), Positives = 355/781 (45%), Gaps = 80/781 (10%)
Query: 541 KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSR--AAGSAQG 598
K +QE +Q + ++ +E T+ + +RK L ++ + + R +
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
Q +++ E++ + ++ E + +LQ ++++Q ++ E+E R E+L +
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR---EQLLKRE 553
Query: 659 NEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAK 718
EK E +QRL+ + E R L +K E E+ Q ++ Q++ E + + +
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQL-----LKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
R E E+ + + +++ + L+ EEQE+ +R+++L + +E+ ++E
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEE---RRQQQLRREQQERREQRLKREEEE 665
Query: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNT----------SEQDQAGTEMRVKLLQ 828
++L+++ E + R E A + E R + SE D +++ + +
Sbjct: 666 ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK 725
Query: 829 EENEKL-QGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEE 887
+E ++ Q + E+ RR ++LQ Q E+ + + +E + + + Q EE R+
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW-QAEEKSERGRQRL 784
Query: 888 KEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLG 947
R E +L A +E++Q ++ E E+KEQ RR + E E E L
Sbjct: 785 SARPPLREQRERQLRA---------EERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 948 KTIEKLQKEMADIVEASRTSTLELQNQL---DEYKEKNRRELAEMQRQLKEKTLEAEKSR 1004
+ + ++E A ++ E Q + ++ +++ R E +R+ + TL A+ +
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA- 894
Query: 1005 LTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS---- 1060
+++ E +L++EE + QR + E +++ Q ++ + + E + L+++R
Sbjct: 895 -LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 1061 -------RLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQE---RA 1110
R K+++ K QL E E+R + E+ R E+++Q +LL+E +
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKRRRQE--REKKYREEEELQQEEEQLLREEREKR 1011
Query: 1111 ARQDLECD---KISLERQNKDL------KSRIIHLEGSYRSSKEGLVVQMEARIAELEDR 1161
RQ+ E K L+++ + L K R+ E YR +E + + E++
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEE---------LQQEEEQ 1062
Query: 1162 LESEERDRANLQLSNRRLERKV-KELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEE 1220
L EER+ Q LER+ KE +Q ++E L + + + + R+ EE ++
Sbjct: 1063 LLGEERETRRRQ----ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 1221 EIDRL--ESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLST 1278
E ++L E +K+ ++ELE Q E +Q + + ++ K+ ++ ++++L
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 1279 D 1279
+
Sbjct: 1179 E 1179
Score = 139 bits (350), Expect = 2e-32
Identities = 167/712 (23%), Positives = 316/712 (44%), Gaps = 63/712 (8%)
Query: 614 EQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE 673
EQ+ +L + ++Q +LE +++Q EE R R +E + E+ + S E
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETE 202
Query: 674 ESEGELRKNLEELFQVKME-REQHQTEIRDLQDQLSEMHDELDSAKRSE--DREKGALIE 730
E E + EL +++ + RE+ Q + R+ QD++ + +E + KR +E+ L E
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
Query: 731 ELLQAKQDLQD----------LLIAKEEQED-----------LLRKRERELTALKGALKE 769
E Q +++LQ+ + +E QE+ LR+++ E + +
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 770 EVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQE 829
E ++ ++ +EQ Q R + + E + EQ++ E +++ Q+
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
+ Q R E+ RR QL+R+ + L+ ++ +E + E ++R+ +E H +K E+E
Sbjct: 383 LRREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 890 AVSARRALENELEAAQGNLSQTTQ--EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLG 947
R E E + T+ EQ++ ++LK + E++ + R LK E E R
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 948 KTIEKLQKEMADIVE--ASRTSTLELQNQLDEYKEKNRRELAEMQRQL----KEKTLEAE 1001
+ ++L++E + E R E Q +++ RRE E + QL +EK LE E
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 1002 KSRLTAMKMQDEMR---LMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD 1058
+ + Q+E R L EE R QR + E + + LEQ LK E E + ++
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKRE---QEERLEQRLKREEVERLEQEERREQ 618
Query: 1059 RSRLVKQMEDKVSQ-LEMELEEERNNSDLLSERISR------SREQMEQLRNELLQE-RA 1110
R + + E++ Q L+ E +EER L E+ R E+ E+L L +E
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678
Query: 1111 ARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRA 1170
R++ E + E+ + +KSRI + S + +AR +++ R +E R
Sbjct: 679 ERREQELAEEEQEQARERIKSRIPKWQWQLES-------EADARQSKVYSRPRKQEGQRR 731
Query: 1171 NLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKK 1230
+ +R R E +Q +E + Q+++ R + Q EE E + S++
Sbjct: 732 RQEQEEKRRRR---ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 1231 KLQRELEEQMDMNEHLQGQLNSMKKD------LRLKKLPSKVLDDMDDDDDL 1276
L+ + E Q+ E Q + + ++ R ++ K L +++++ L
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Score = 129 bits (323), Expect = 2e-29
Identities = 141/626 (22%), Positives = 284/626 (45%), Gaps = 88/626 (14%)
Query: 642 EERERMRANLEELRSQHNEKVEENSTLQQR---LEESEGELRKNLEELFQVKMEREQHQT 698
+E +R R + +E Q + E+ + R LEE G+ R+ Q + E+E+
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRR------QKRQEQER--- 146
Query: 699 EIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRER 758
+L+E ++ + +R E R++ EEL + +Q+ Q+ +EE+ R E
Sbjct: 147 -------ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE----REER----RAEEE 191
Query: 759 ELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQA 818
+L + KG EE +Q + EL LR R E+ Q
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRR-------ELLELR---------------RKGREEKQQQ 229
Query: 819 GTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEE 878
E + ++ QEE EK E +R L+++ E L+ +E + + L++ E ++R+LE
Sbjct: 230 RRERQDRVFQEEEEK------EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 879 ALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE 938
+ ++E+E R E +L + K+E E++EQ + +
Sbjct: 284 QELRRERQEEEQQQQRLRREQQL-------------------RRKQEEERREQQEERREQ 324
Query: 939 MENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQ---LKE 995
E + ++L++E E R L + + + +++ RRE E +R+ +E
Sbjct: 325 QERREQQEERREQQLRREQ----EERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 996 KTLEAEKSRLTAMKMQDEMRL-MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSH 1054
+ L E+ +++ E +L E++LR Q+ + E +R+ +Q ++ E E + H
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQEEERHEQKH 438
Query: 1055 LKDDR-SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQ 1113
++ R RL ++ E++ L+ E E ER+ + +++ R +E+ + R L+E R+
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 1114 DLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQ 1173
E + L R+ ++ + + + + ++ L + + R E E+R E + +
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR-REQEERREQLLKREEEKR 557
Query: 1174 LSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAE-EEIDRLESSKKKL 1232
L R E+++K + D+ L +++ Q L+ + +R + + EE++RLE +++
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE 617
Query: 1233 QRELEEQMDMNEHLQGQLNSMKKDLR 1258
QR L+ + E Q L S +++ R
Sbjct: 618 QR-LKREEPEEERRQQLLKSEEQEER 642
Score = 124 bits (311), Expect = 6e-28
Identities = 172/823 (20%), Positives = 351/823 (42%), Gaps = 90/823 (10%)
Query: 483 RAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPD-LLK 541
R L Q ++EEEV+ L+ + P+ ++ + + Q + LL+
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREE------PEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 542 GQQELTQQTNEETAKQ---ILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG 598
+QE +Q E ++ + K+ D D + K EK ++
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD-------- 1237
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
N C + Q + + Q+ LQ + QQ E+ER R +
Sbjct: 1238 NKVYCKGREN--EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE 1295
Query: 659 NEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAK 718
E++E + + + + + K L L + + E+ + Q R +++ + + +
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQL--LREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
R ++R++ EEL +Q + L E+E LR++ERE LK + +Q++
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFL-----EEEQRLRRQERERKFLKEEQQLRCQEREQQL 1408
Query: 779 --DKLKEQYDAELQALRESVEEATKNVEVLASRSNTS----EQDQAGTEMRVKLLQEENE 832
D+ ++ + E Q R+ + + E R E++Q + R + +EE +
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Query: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
LQ R E+ QL RQ D K E + + L++ E + + E+ L R +E E
Sbjct: 1469 LLQEREEQ------QLHRQERDRKFLEEE--QQLRRQERDRKFREQEL---RSQEPE--- 1514
Query: 893 ARRALENELEA-AQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIE 951
R+ LE E + Q + QE++QL + + + ++++ R+ + E + + + +
Sbjct: 1515 -RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 952 KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ 1011
+ +++ +E + E + + E +++ RR+ E Q+QL+++ + ++ +
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQ--EGQQQLRQERDRKFREDEQLLQER 1631
Query: 1012 DEMRLMEEELRDYQRAQDEALTKRQLLEQTLK-----------DLEYELEAKSHLKDDRS 1060
+E +L +E RD + ++E +RQ EQ L+ L E E + + +R
Sbjct: 1632 EEQQLHRQE-RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD 1690
Query: 1061 RLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQD-----L 1115
R ++ E ++ + E E + + L + + R + EQLR E QE+ RQ+ L
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLS 1175
E +++ ER+ + L+ + + +R ++ R E +L S+E DR +
Sbjct: 1751 EEEQLRPEREEQQLRRQ--ERDRKFREEEQ-------LRQEREEQQLRSQESDRKFREEE 1801
Query: 1176 NRRLERKVKELVMQVDD-------EHLSLTDQKDQL------SLRLKAMKRQVEEAEEEI 1222
R ER+ ++L Q D E L L +Q+ +L R + E++ E
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Query: 1223 DRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSK 1265
L +++ +R+ E+ EH++ Q ++ ++ ++ S+
Sbjct: 1862 QELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Score = 121 bits (304), Expect = 4e-27
Identities = 161/729 (22%), Positives = 323/729 (44%), Gaps = 81/729 (11%)
Query: 612 LLEQKSKLTIEVAELQ--RQLQLEVKNQQNIKEERE-RMRANL-------EELRSQHNEK 661
L E++ K ++ E Q + +L+ + +Q + EERE R R L EEL+ + +
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 662 VEENSTLQQRLE-----ESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 716
+ E ++R E E EL++ E+L + + E+ + Q R +++ +E
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 717 AKRSEDREKGALIEELLQAKQDLQ--DLLIAKEEQEDLLRKRER----ELTALKGALKEE 770
+ ++ + +E + +++LQ + + +EEQE ++RER E + K+
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 771 VSSHDQEMDKLKEQYDAELQ-ALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQE 829
DQ D LK Q++ E + A+R+ N R N + +++R + Q+
Sbjct: 1214 YRDEDQRSD-LKWQWEPEKENAVRD-------NKVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 830 ENEKLQGRSEELE-----RRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR 884
+ + L G +E + RR Q R + + E + ++ K+ + + ++ ++ L R
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER 1325
Query: 885 KEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE------ 938
+E++ R E + Q Q + Q++ + +EE +EQ R+ E
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR 1385
Query: 939 MENERWHLGKTIEKLQKEMADIVEASRTSTL---ELQNQLDEYKEKNRRELAEMQRQLKE 995
E ER L + + +E + R E Q E K R E +++RQ +E
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 996 KTLEAEKSRLTA---MKMQDEMRLMEE--------ELRDYQRAQDEALTKRQLLEQTLKD 1044
+ E+ +L K ++E +L++E + RD + ++E +RQ ++ ++
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 1045 LEYELE--AKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLR 1102
E + + L++++ +Q + K Q E +L + +R + RE+ EQLR
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE-EQLR 1564
Query: 1103 NELLQERAARQD------LECDKISLERQNKDL---KSRIIHLEG--SYRSSKEGLVVQM 1151
E +++ +RQ+ LE K+ + Q + + ++ EG R ++ +
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED 1624
Query: 1152 EARIAELED-RLESEERDRANLQLSNRRLERKVKELVMQVD-----DEHLSLTDQKDQLS 1205
E + E E+ +L +ERDR L+ +L R+ +E ++ D E L + ++
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLE-EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683
Query: 1206 LRLKAMKRQVEEAEEEIDRLESSKKKLQ-----RELEEQMDMNEHLQGQLNSMKKDLRLK 1260
LR + R+ E E+++ R E +K LQ R E + E Q + + ++ LR +
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743
Query: 1261 KLPSKVLDD 1269
+ K+L++
Sbjct: 1744 ERYRKILEE 1752
Score = 120 bits (302), Expect = 6e-27
Identities = 158/747 (21%), Positives = 334/747 (44%), Gaps = 99/747 (13%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
E ++L +++ +L E E +R+ +LE + ++ + ++E + EE + +++E
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171
Query: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQ-----------DQLSEMHDELDS 716
++ L++ E +L + EE + + ERE+ E +LQ DQ S++ + +
Sbjct: 1172 EEEELQQEEEQLLR--EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229
Query: 717 AKRSEDRE-----KGALIEEL----------LQAKQDLQDLLIAKEEQEDLLRKRERELT 761
K + R+ KG E+ Q++QDLQ LL ++E++ +R +
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 762 ALKGALKEEVSSHDQEMDKLKE-QYDAELQALRESVEEATKNVE----------VLASRS 810
+E++ +Q+ K ++ + E Q LRE EE + E +L R
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 811 NT-----------SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE 859
E++ E K L+EE R +E ER+ + ++Q+ + ++
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL---RRQERERKFLKEEQQLRCQEREQ 1406
Query: 860 AKAKETLKKYEGEIRQL---------EEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910
++ +K+ E +QL E R++E+E R+ LE E + Q +
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE----RKFLEEEQQLRQERHRK 1462
Query: 911 TTQEQKQLSEKLKEESEQKEQLRRLKNE------MENERWHLGKTIEKLQKEMADIVEAS 964
+E++ L E+ +++ ++E+ R+ E E +R + + + E + E
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQ 1522
Query: 965 RTSTLELQNQ-LDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRD 1023
+ + Q + L E ++ R+E + +RQ +++ E+ ++ + E + + + RD
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ----LRQEREEQQLSRQERD 1578
Query: 1024 YQRAQDEALTKRQLLEQTLKDLEYEL---EAKSHLKDDRSRLVKQMEDKVSQLEMEL--E 1078
+ +E +RQ E+ + E +L E + L+ +R R ++ E + + E +
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQD----LECDKISLERQNKDLKSRII 1134
+ER+ L E R +E+ +QLR++ ++R R++ E ++ L RQ +D K R
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHD--RDRKFREEEQLLQEGEEQQLRRQERDRKFR-E 1695
Query: 1135 HLEGSYRSSKEGLVVQMEARI--AELEDRLESEERDRANLQLSNRRLERKVKELV----M 1188
+ R +E +Q E ++ ELE + EE+ R + R + + ++++ +
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 1189 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAE----EEIDRLESSKKKLQRELEEQMDMNE 1244
+ + E L Q+ R + RQ E + +E DR +++L++E EEQ +
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Query: 1245 HLQGQLNSMKKDLRLKKLPSKVLDDMD 1271
G+ ++ L+L++ ++ + D
Sbjct: 1816 QRDGKYRWEEEQLQLEEQEQRLRQERD 1842
Score = 119 bits (298), Expect = 2e-26
Identities = 163/659 (24%), Positives = 299/659 (45%), Gaps = 71/659 (10%)
Query: 626 LQRQLQLEVKNQQNIKEERERM-RANLEELRSQHNEK-VEENSTLQQRLEESEGELRKNL 683
LQ QL+ K QQ ++EE E + R E+ R Q E+ E LQQ E E LR+
Sbjct: 895 LQEQLR---KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ---EEEQLLREER 948
Query: 684 EELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLL 743
E+ + + ERE+ + + LQ + ++ E +R ++REK EE LQ +++
Sbjct: 949 EK--RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ---- 1002
Query: 744 IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM---DKLKEQYDAELQALRESVEEAT 800
+ +EE+E KR R+ + K+E+ ++++ ++ K + + RE E
Sbjct: 1003 LLREERE----KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 801 KNVEVLASRSNTSEQDQAGTEMRVK--LLQEENEKLQGRSEELERRVAQLQ-RQIEDLKG 857
+ ++L T + + + R + L QEE + L+ E+ R+ + Q R+ E+L+
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 858 DEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQ 917
+E E L + E E R+ +E R+EE+ + L E E + Q + Q +
Sbjct: 1119 EE----EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR---RQELERQYR 1171
Query: 918 LSEKLKEESEQ----KEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTL---- 969
E+L++E EQ +++ RR E ER + + + QK + + S L
Sbjct: 1172 EEEELQQEEEQLLREEQEKRR----QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Query: 970 --ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSR--LTAMKMQDEMRLMEEELRDYQ 1025
E +N + + K + E RQL++ L +S+ L + + + R E+E R +Q
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ 1287
Query: 1026 R-----AQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQME-DKVSQLEMELEE 1079
+ ++E L + + E +D + + E K L+++R ++ E D+ + E +L +
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQ-EEKQLLREEREEKRRRQETDRKFREEEQLLQ 1346
Query: 1080 ERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS 1139
ER L R R R+ E+ EL + R+ LE ++ L RQ ++ K +
Sbjct: 1347 EREEQPL--RRQERDRKFREE---ELRHQEQGRKFLE-EEQRLRRQERERKFLKEEQQLR 1400
Query: 1140 YRSSKEGLVVQMEARIAELEDRLESEERDR----ANLQLSNRRLERKVKELVMQVDD--- 1192
+ ++ L + + E E +L +ERDR Q+ + ERK E Q+
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 1193 ----EHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQ 1247
E L ++++ L + R+ E E+++ R E +K ++EL Q + L+
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Score = 118 bits (295), Expect = 4e-26
Identities = 139/664 (20%), Positives = 299/664 (45%), Gaps = 59/664 (8%)
Query: 614 EQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE 673
E++ + E+ + + QL E + ++ + +ERER EEL+ + + + E ++R E
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRL-QERERQYREEEELQQEEEQLLGEERETRRRQE 1075
Query: 674 -----ESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL 728
E EL++ E+L + + E+ + Q R +++ +E + ++ +
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE 1135
Query: 729 IEELLQAKQDLQDLLIAKEEQEDLLRKR--ERELTALKGALKEEVSSHDQEMDKLKEQYD 786
+E + ++++Q +E+E LLR+ +R L+ +EE +E L+E+ +
Sbjct: 1136 LERQYREEEEVQ------QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE 1189
Query: 787 AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVA 846
Q RE + ++ + ++DQ ++++ + E+ ++ + R
Sbjct: 1190 KRRQE-RERQYREEEELQRQKRKQRYRDEDQR-SDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 847 QLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEA-VSARRALENELEAAQ 905
+ RQ+ED + + ++++ L+ GE ++ + R ++++ LE E +
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA 1307
Query: 906 GNLSQTTQEQKQLSEKLKEESEQKEQLRR-------LKNEMENERWHLGKTIEKLQKEMA 958
+ +QE+KQL + +EE ++++ R L E E + + K ++E
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL 1367
Query: 959 DIVEASRTSTLELQN-QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLM 1017
E R E Q + E + K +E +++ Q +E+ L ++ R K ++E + +
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR----KFREEEQQL 1423
Query: 1018 EEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMEL 1077
+ RD + ++E +RQ E+ LE + L+ +R R ++ E QL E
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKF------LEEEQQLRQERHRKFREEE----QLLQER 1473
Query: 1078 EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLE 1137
EE++ + ER + E+ +QLR + + Q+L S E + K L+ +
Sbjct: 1474 EEQQLHR---QERDRKFLEEEQQLRRQERDRKFREQELR----SQEPERKFLEEE----Q 1522
Query: 1138 GSYRSSKEGLVVQMEARIAELE-DRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLS 1196
+R ++ +Q E ++ E + ++RDR + R ER+ ++L Q D
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582
Query: 1197 LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRE----LEEQMDMNEHLQGQLNS 1252
L +QK +R + +R+ E E+++ R E ++ Q E++ + E + QL+
Sbjct: 1583 LEEQK----VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 1253 MKKD 1256
++D
Sbjct: 1639 QERD 1642
Score = 108 bits (271), Expect = 3e-23
Identities = 107/476 (22%), Positives = 228/476 (47%), Gaps = 50/476 (10%)
Query: 814 EQDQAGTEMRVKLLQEE-NEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
E+DQ E R + L+EE ++ + + +E ER +A+ G+E K+ ++ E
Sbjct: 116 EEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE---------GEEQSEKQ--ERLEQR 164
Query: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE--------KLKE 924
RQ + + +++E + RRA E +L++ +G+ ++ +++QL K +E
Sbjct: 165 DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGRE 224
Query: 925 ESEQ--KEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKN 982
E +Q +E+ R+ E E + W +T+ L+KE + E ELQ + ++ ++
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETV--LRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 983 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTL 1042
R+EL +++ +++ + + K ++E R +EE R+ Q +++ +R+
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE------ 336
Query: 1043 KDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM---E 1099
+ L E E + ++ + R ++ E + QL E EEER L E+ R +Q+ +
Sbjct: 337 QQLRREQEER---REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 1100 QLRNE--LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE 1157
QLR E L +E+ R++ + + R+ + L+ + +E +++ E
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 1158 LEDRLESE------ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAM 1211
D L+ E E++R QL + E + + + ++E ++++Q R +
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 1212 KRQV----EEAEEEIDRLESSKKKLQRELEEQMD--MNEHLQGQLNSMKKDLRLKK 1261
+R+ +E EE + + S+++L+RE EE+ + + + +L +++ RLK+
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Score = 60.1 bits (144), Expect = 1e-08
Identities = 70/325 (21%), Positives = 146/325 (44%), Gaps = 29/325 (8%)
Query: 591 RAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRAN 650
R G Q + E + LL+++ + + E R+ LE + Q +E +++R +
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF-LEEEPQLRRQEREQQLRHD 1664
Query: 651 LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM 710
+ + + ++E Q R +E + + R+ ++L + + ER + LQ++
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER-------KFLQEEQQLR 1717
Query: 711 HDELDSAKRSEDREKGALIEELLQAKQDLQDLL----IAKEEQEDLLRKRERELTALKGA 766
EL+ R E++ + +E L+ ++ + +L + E +E LR++ER+ +
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD----RKF 1773
Query: 767 LKEEVSSHDQEMDKLKEQYD----AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
+EE ++E +L+ Q E + LR+ EE + + E+ E
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833
Query: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVH 882
+L QE + Q R+EE + +R+ ++L +E E ++ E E + EE H
Sbjct: 1834 EQRLRQERDR--QYRAEEQFATQEKSRREEQELWQEE----EQKRRQERERKLREE---H 1884
Query: 883 ARKEEKEAVSARRALENELEAAQGN 907
R+++KE R+ E + + +G+
Sbjct: 1885 IRRQQKEEQRHRQVGEIKSQEGKGH 1909
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 150 bits (379), Expect = 8e-36
Identities = 186/845 (22%), Positives = 354/845 (41%), Gaps = 134/845 (15%)
Query: 520 KKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVN 579
K VK +P L++ Q Q N++ Q L + L++ + ++ +
Sbjct: 1227 KNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNE-----LR 1281
Query: 580 LVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQN 639
L +++++ S S S++ D E +L E + Q Q + +Q
Sbjct: 1282 LNSDRLESRISELTSELTDERNTGESASQLLDA-ETAERLRAEKEMKELQTQYDALKKQM 1340
Query: 640 IKEERERMRANLEELRSQHNEKVEENSTLQQRL--EESEGEL---RKNLEELFQVKMERE 694
E E M A L + E ++++ + RL E + E+ +K L++ F+ K+E E
Sbjct: 1341 EVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVE 1400
Query: 695 QHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLR 754
Q R L+ +L ++ + + ++R+ + K + L QD + L ++ + L
Sbjct: 1401 QQNK--RQLERRLGDLQADSEESQRALQQLKKKC-QRLTAELQDTKLHLEGQQVRNHELE 1457
Query: 755 KRERELTALKGALKEEVSSHDQEMDKLKEQYD---AELQALRESVEEATKNVEVLASRSN 811
K++R + EE + +KL+ + D AE +L++ +EE
Sbjct: 1458 KKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEE------------- 1504
Query: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871
+ D AG +V L+ E + + + + E +A++++Q+ DL+ +E L + G
Sbjct: 1505 -KDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAG 1563
Query: 872 EIRQLEEALVHARKE-EKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 930
I+ LE+A + E E+ + + +E+ E + ++ KQ+ +L+EE E K+
Sbjct: 1564 TIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 931 QLRRLKNEMENERWHLGKTIEKL----QKEMADIVEASRTSTLELQNQLDEYKEK--NRR 984
++ R K E+E + L + + +K + ++ ++ + Q LD K ++R
Sbjct: 1624 KVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKR 1683
Query: 985 ELAEMQRQLKEK---------------------------------TLEAEKSRLTAMKMQ 1011
E+A+++ QL+E LE + SRL K +
Sbjct: 1684 EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNE 1743
Query: 1012 DEMRLMEEE-----------------------LRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
+ RL E++ + D Q +EA ++Q L++ L+ L+ +
Sbjct: 1744 IQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQ 1803
Query: 1049 LEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQE 1108
+E D+S LV + E K+ +LE LE ER L SR +E ME+L E Q
Sbjct: 1804 VEFLEQSMVDKS-LVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQR 1862
Query: 1109 RAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERD 1168
AA + L+RQ +D K + G + + EA + + L E D
Sbjct: 1863 IAAENREKEQNKRLQRQLRDTKEEM------------GELARKEAEASRKKHEL---EMD 1907
Query: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESS 1228
+L+ +N+ L+ +K ++ D ++ D+ + +E E+ I+ L+
Sbjct: 1908 LESLEAANQSLQADLKLAFKRIGDLQAAIEDEMES------------DENEDLINSLQDM 1955
Query: 1229 KKKLQR---ELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYE 1285
K Q+ +LE D++ L+ +++ +K L K PSK D DG
Sbjct: 1956 VTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASD---------DGSLKSS 2006
Query: 1286 APVSY 1290
+P SY
Sbjct: 2007 SPTSY 2011
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 148 bits (374), Expect = 3e-35
Identities = 153/659 (23%), Positives = 307/659 (46%), Gaps = 82/659 (12%)
Query: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
E+ L E+ K + ELQ QL+ + + ++ ++ +++A+LE+L N+ ++EN+
Sbjct: 1093 EITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF 1152
Query: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGA 727
LQ E+L ++KM E+ + ++ +L +L +E S K S ++ +
Sbjct: 1153 LQ--------------EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
Query: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
L ++ L+ K+ ++L I Q D+ K+ L K +SS + +A
Sbjct: 1199 LEDKSLEFKKLSEELAI----QLDICCKKTEALLEAKTNELINISS---------SKTNA 1245
Query: 788 ELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQ 847
L + TK E L ++ T + E +++ L EE L ++ ++ +
Sbjct: 1246 ILSRISHCQHRTTKVKEALLIKTCTVSE----LEAQLRQLTEEQNTLNISFQQATHQLEE 1301
Query: 848 LQRQIEDLKGD---EAKAKETLKKYEGEIRQL----EEALVHARKEEKEAVSARRALENE 900
+ QI+ +K D KE L+K G +Q E + +KE E ++A ++ E
Sbjct: 1302 KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEE 1361
Query: 901 LEAAQGNLSQTTQEQKQLSEKLKEE---SEQKEQLRRLKNEMENERWHLGKTIEKLQKEM 957
L+ + +S +++ L+ +L+ SE++ + L+ + + E+ L ++ L ++
Sbjct: 1362 LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV 1421
Query: 958 ADIVEASRTSTLE----LQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE 1013
D + + S LE N+ E+K+K + + Q +KE ++ E A + ++
Sbjct: 1422 -DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480
Query: 1014 MRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL 1073
+ L++EEL D Q + + L K ++ + K + E ++ LK +R++ ++ED ++Q
Sbjct: 1481 INLLKEEL-DQQNKRFDCL-KGEMEDDKSKMEKKESNLETELKSQTARIM-ELEDHITQK 1537
Query: 1074 EMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRI 1133
+E+E L+E + +Q + EL+Q+ Q+L +K + + K+ + +I
Sbjct: 1538 TIEIES-------LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK---DNRVKEAEEKI 1587
Query: 1134 IHLEGSYRSSKEGL-------------VVQMEARIAELEDRLESEERDRANLQLSNRRLE 1180
+ LE S K L V E + LEDRLESE A L R+ E
Sbjct: 1588 LTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE--SAAKLAELKRKAE 1645
Query: 1181 RKV----KELVMQVDDEH----LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 1231
+K+ K+L+ Q++++ +L+ +L+ +R+V EE++ +ESS+ +
Sbjct: 1646 QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSE 1704
Score = 132 bits (331), Expect = 3e-30
Identities = 193/872 (22%), Positives = 380/872 (43%), Gaps = 97/872 (11%)
Query: 480 TVIRAP---SLGAQSKKEEEVKTATAT----LMLQNRATATSP----DSGAKKISVKTFP 528
++ R+P SL S KE V+T++ L L + + P DS A+ + V
Sbjct: 74 SLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDL-VGNSD 132
Query: 529 SASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGS-------TDNDDATKRKVNLV 581
S + Q L + ++ L+ + + Y L+ + + D + R++ +
Sbjct: 133 SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192
Query: 582 FEKIQT-------LKSRAAGSAQGNNQACNSTSEVKDLLEQKSKL-TIEVAELQRQLQLE 633
E++Q L+ S + +Q + LL+Q+ + + V L+ QLE
Sbjct: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLE 252
Query: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
+ + KEE E + V+ TLQQR++ E L++ E + K +
Sbjct: 253 PQAEVFTKEENPESDG---EPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309
Query: 694 EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL------LIA-- 745
+E LQ+QL E EL+ K EK LI +L AK ++ L +IA
Sbjct: 310 TLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAET 369
Query: 746 KEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEV 805
K + + L +E E+ L+ +K+ + ++ ++ ++ A + L +++ A K E
Sbjct: 370 KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE- 428
Query: 806 LASRSNTSEQDQ-------AGTEMRVKLLQE----ENEKLQGRSEELERRVAQLQRQIED 854
A R +E D+ E R+ L QE + E + + E ++A+LQ+ E
Sbjct: 429 -ARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE- 486
Query: 855 LKGDEAKAKETLKKYEGEIRQLEEAL-------------VHARKEEKEAVSARRALENEL 901
K K +E KK + R+ +E + + KE++E++ A LE +
Sbjct: 487 -KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL-ALEELELQK 544
Query: 902 EA----AQGNLSQTTQEQKQLSEKLKE-ESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956
+A ++ L QE + ++ E ES ++ L+ KN+ ++ HL K KE
Sbjct: 545 KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKE 604
Query: 957 MADIVEASRTSTLELQNQLDE-YKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMR 1015
+ +VE +T L++Q D + EK + + Q ++++ + E+ + T +K D+
Sbjct: 605 ITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK--DKEI 662
Query: 1016 LMEEELRDYQRAQDEALTKRQL-LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLE 1074
+ + + + E L +Q LE +L L+A+ L+++ S L Q + +LE
Sbjct: 663 IFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE 722
Query: 1075 MELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDL---ECDKISLERQN--KDL 1129
+++E++N+ + I + E Q + L+++ + +L E DK E Q ++L
Sbjct: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
Query: 1130 KSRIIHLEG-------------SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSN 1176
++ I EG SY+S+ E ++A+L+ +L E +R L
Sbjct: 783 EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 842
Query: 1177 RRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID-RLESSKKKLQRE 1235
+E + K++ ++D + + D QL + M+++V+ + + +LE K+ ++
Sbjct: 843 AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQT 902
Query: 1236 LEEQMDMNEHLQGQLNSMKKDLRL--KKLPSK 1265
+ ++ + KK++ + +KL +K
Sbjct: 903 KQILVEKENMILQMREGQKKEIEILTQKLSAK 934
Score = 131 bits (329), Expect = 5e-30
Identities = 161/806 (19%), Positives = 350/806 (43%), Gaps = 79/806 (9%)
Query: 472 ETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRA--TATSPDSGAKKISVKTFPS 529
E E +Q + I+ + + +E++ K+ A +A TA + +K+ +
Sbjct: 381 EEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ 440
Query: 530 ASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTD--------NDDATKRKVNLV 581
+ T + ++ ++ Q KQ + + +K+ S + ++ RK +
Sbjct: 441 IKTIEKTSE----EERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQEL 496
Query: 582 FEKIQTLKSRAAGSAQGNNQACNSTS-EVKDLLEQKSKLTIEVAELQRQLQL-EVKNQ-Q 638
+K+QT + + + S ++ EQ+ L +E ELQ++ L E +N+ +
Sbjct: 497 TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLR 556
Query: 639 NIKEERERMRANLEELRSQHNEKVEENSTLQQRLE-ESEGELRKNLEELFQVKMEREQHQ 697
++++E E R + EL S + ++EN + L E E K+ +E + + E+H+
Sbjct: 557 DLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKE---ITVMVEKHK 613
Query: 698 TEIRDLQDQLSEMHDE-LDSAKRSEDREKGALIEELLQAKQDL-QDLLIAKEEQEDLLRK 755
TE+ L+ Q + E L K+ E L E+ Q K+ L +D I + + + +
Sbjct: 614 TELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673
Query: 756 RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQ 815
+ E +K E +SS E+ K + + + EL L++ ++ + +E Q
Sbjct: 674 KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ 733
Query: 816 DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQ 875
Q + +++E +Q + L+ ++ QL+ +++ + LK+++ +
Sbjct: 734 QQVDS-----IIKEHEVSIQRTEKALKDQINQLELLLKE-------RDKHLKEHQAHVEN 781
Query: 876 LEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRL 935
LE + + E EL+ A L Q E+ K EQ QL++
Sbjct: 782 LEADI--------------KRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
Query: 936 KNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE 995
++E ER L K + +++ + D+ +++Q+ + + +++N +EM++++K
Sbjct: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN----SEMEQKVKS 883
Query: 996 KTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHL 1055
T ++ E +L D + Q++ TK+ L+E+ L+ K +
Sbjct: 884 LT-----------------QVYESKLEDGNKEQEQ--TKQILVEKENMILQMREGQKKEI 924
Query: 1056 KDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERI-SRSREQMEQLRNELL-QERAARQ 1113
+ +L ED + L E E + N + E++ +++E E L+ +LL QE ++
Sbjct: 925 EILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983
Query: 1114 DLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRAN-- 1171
+LE + L ++ K ++++ + + + V ++E E + L R N
Sbjct: 984 ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV 1043
Query: 1172 LQLSNRRLERKVKELVMQVDDEHLSLTDQK-DQLSLRLKAMKRQVEEAEEEIDRLESSKK 1230
+ + ++L ++ +EL ++ + L +Q+ +L ++ + EE +EI L+
Sbjct: 1044 ISIWEKKLNQQAEEL-QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV 1102
Query: 1231 KLQRELEEQMDMNEHLQGQLNSMKKD 1256
K L E + + +NS+ +D
Sbjct: 1103 KQDTTLNELQEQLKQKSAHVNSLAQD 1128
Score = 123 bits (309), Expect = 1e-27
Identities = 204/884 (23%), Positives = 380/884 (42%), Gaps = 165/884 (18%)
Query: 492 KKEEEVKTATATL-MLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQT 550
+ E E++ A+A L + Q+ +AT + A + + A Q DL + LT+Q
Sbjct: 788 RSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL-----AQLQQKLLDLETERILLTKQV 842
Query: 551 NEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSE-- 608
E A++ K+ T+ D A K +V + ++++ S + Q S E
Sbjct: 843 AEVEAQK------KDVCTELD-AHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG 895
Query: 609 ------VKDLLEQKSKLTIEVAELQRQLQLEVKNQQN---------IKEERERMRANLEE 653
K +L +K + +++ E Q++ ++E+ Q+ + EE E N E+
Sbjct: 896 NKEQEQTKQILVEKENMILQMREGQKK-EIEILTQKLSAKEDSIHILNEEYETKFKNQEK 954
Query: 654 LRSQHNEKVEE-NSTLQQRLEESEGELRKNLEEL----------FQVKMEREQHQTEIRD 702
+ +K +E TL+++L + E +L+K LE F KM E Q
Sbjct: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM-LEMAQANSAG 1013
Query: 703 LQDQLSEMH----DELDSAKRSEDREKGALI----EELLQAKQDLQDLLIAKEEQEDLLR 754
+ D +S + ++++S RE +I ++L Q ++LQ++ E L+
Sbjct: 1014 ISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI------HEIQLQ 1067
Query: 755 KRERELTALK------GALKEEVSSHDQEMDKLKEQ---YDAELQALRESVEEATKNVEV 805
++E+E+ LK G KEE++ +E+ LKE+ D L L+E +++ + +V
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMN---KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124
Query: 806 LASRSNTSEQDQAGTEMRVK-------LLQEENEKLQGRSEELERRVAQL-------QRQ 851
LA + E+ + LQE+ +L+ +EE +R+V++L +
Sbjct: 1125 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEE 1184
Query: 852 IEDLKGDEAKAKETLKKYEGEIRQLEE--------------ALVHARKEE---------- 887
+ LK K+ ++L+ E ++L E AL+ A+ E
Sbjct: 1185 FQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTN 1244
Query: 888 ----------------KEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ 931
KEA+ + +ELEA L Q T+EQ L+ ++ + Q E+
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEA---QLRQLTEEQNTLNISFQQATHQLEE 1301
Query: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
M+ + L E LQKE + +A+ + QL + +N + M+
Sbjct: 1302 KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI-TQLKKELSENINAVTLMKE 1360
Query: 992 QLKEKTLEAEK--SRLTAM--KMQDEMRLMEEE--LRDYQRAQDEALTKRQLLEQTLKDL 1045
+LKEK +E +LT + ++Q+ + L E+E + ++ DE K +LL+Q ++DL
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE--KCELLDQ-VQDL 1417
Query: 1046 EYELEAKSHLK-------DDRSRLV----KQMEDKVSQLEMELEEERNNSDLLSERISRS 1094
++++ S K DD S K+ + + +Q + ++E + +L S+
Sbjct: 1418 SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK 1477
Query: 1095 REQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEAR 1154
EQ+ L+ EL Q+ + +C K +E ++ + +LE +S AR
Sbjct: 1478 DEQINLLKEELDQQN---KRFDCLKGEMEDDKSKMEKKESNLETELKSQT--------AR 1526
Query: 1155 IAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQ 1214
I ELED + + + L +K Q D EH L + + +
Sbjct: 1527 IMELEDHITQKT-------IEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 1215 VEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
V+EAEE+I LE+ ++ ELE + EH+ + S +++L+
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Score = 112 bits (279), Expect = 3e-24
Identities = 178/767 (23%), Positives = 342/767 (44%), Gaps = 97/767 (12%)
Query: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTL--KSRAAGSAQGNNQA 602
EL Q + T +Q N + +T + + ++ + I++L + A GN Q
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 603 CNSTSEV------KDLLEQKSKLT----------IEVAELQRQL-QLEVKNQQNIK-EER 644
S E K+L E + +T +E++ L +QL L V+ Q +I E+
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Query: 645 ERMRANLEELRSQHNEK-------VEENS----TLQQR----LEESEGELRKNLEELFQV 689
E A + LR Q++E+ V++ S TL + LE+ + K E +
Sbjct: 1393 E---AAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749
+ QHQ +++LQ QL EL S + E E+ L++E L + D L K E
Sbjct: 1450 QSRFTQHQNTVKELQIQL-----ELKSKEAYEKDEQINLLKEELDQQNKRFDCL--KGEM 1502
Query: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLAS- 808
ED K E++ + L+ LK + ++ E++ Q E+++L E ++ + ++
Sbjct: 1503 EDDKSKMEKKESNLETELKSQ-TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
Query: 809 --------RSNTSEQDQAGTEMRVKLLQEENE------KLQGRSEELERRVAQLQRQIED 854
+ E+D E K+L EN+ +L+ + +ELE ++ + E+
Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
Query: 855 LKGDE--------AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQG 906
LK E AK E +K E +I +++ L+ +E++E ++ E+ L
Sbjct: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY--KKGTESHLSELNT 1679
Query: 907 NLSQTTQEQKQLSEKLKE-ESEQKEQL---RRLKNEM---ENERWHLGKTIEKLQKEMAD 959
L + +E L EKLK ES Q E L R KN E E ++K +E
Sbjct: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739
Query: 960 IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019
+++ + T +L ++ + KE+ EM+ Q +E+ ++ E + + Q + ++E
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799
Query: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079
EL + + +L Q +E+ + + ++AK +L++ + K +++K ++ ++
Sbjct: 1800 ELEEKNKKY--SLIVAQHVEK--EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQK 1855
Query: 1080 ERNNSDLLSERISRSREQMEQLRNELLQERAARQ-DLECDKISLERQNKDLKSRIIHLEG 1138
+ L + R +ME+L ++ + +A +Q D L +N + KS+ HL
Sbjct: 1856 IKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS-HLV- 1913
Query: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198
+ L+ MEA+ +LE +L ER++ L RL++ ++ L + E L
Sbjct: 1914 -----QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILK 1968
Query: 1199 DQKDQLSLRLKAMKRQVEEAEEEID-RLESSKKKLQRELEEQMDMNE 1244
+ DQ + ++++ +E+++ + S+ K+L RE Q+ E
Sbjct: 1969 KEYDQ------EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKE 2009
Score = 94.0 bits (232), Expect = 9e-19
Identities = 156/718 (21%), Positives = 295/718 (41%), Gaps = 111/718 (15%)
Query: 534 QATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAA 593
Q T L+ Q EL + E +QI N LKE + D KR L E
Sbjct: 1457 QNTVKELQIQLELKSKEAYEKDEQI--NLLKE---ELDQQNKRFDCLKGEMEDDKSKMEK 1511
Query: 594 GSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRA--NL 651
+ + + T+ + +L + ++ TIE+ L L+ NQQ E +E ++ +
Sbjct: 1512 KESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY--NQQKDIEHKELVQKLQHF 1569
Query: 652 EELRSQHNEKVEENS----TLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQL 707
+EL + + +V+E TL+ ++ + EL +EL V + + + E++ L+D+L
Sbjct: 1570 QELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL 1629
Query: 708 -SEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQE-----DLLRKRERELT 761
SE +L KR +++ A+ ++LL ++ ++ E L++RERE+
Sbjct: 1630 ESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVH 1689
Query: 762 ALKGALKEEVSSHDQEM---------DKLKEQYDAELQALRESVEEATKNV--------E 804
L+ LK SS + + EQ +A+ Q + E +V E
Sbjct: 1690 ILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE 1749
Query: 805 VLASRSNTSEQDQAGT--EMR-------VKL-----LQEENEKLQGR-SEELERR----- 844
L R +++ + EMR +KL Q E++ + G EELE +
Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 845 --VAQ----------------LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR-- 884
VAQ L+ +D++ + + T + E +I++L+ LV +
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869
Query: 885 -KEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE----- 938
+ E E ++++ L+ G T ++ EK K Q + L ++ +
Sbjct: 1870 HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLE 1929
Query: 939 -----MENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE---KNRRELAEMQ 990
E E+ LGK I +LQK++ + + + L+ + D+ +E K +E E++
Sbjct: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989
Query: 991 RQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELE 1050
K L E + A K Q+ ++E + Q + E LLE ++ L+
Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE------LLESHQEETNQLLK 2043
Query: 1051 AKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERA 1110
+ DD R K+ E+ + E E ++ ++ + Q+E+L+ + Q+
Sbjct: 2044 KIAEKDDDLKRTAKRYEEILDAREEE----------MTAKVRDLQTQLEELQKKYQQKLE 2093
Query: 1111 ARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERD 1168
++ D +++ L + + S +E +I LEDRL+ E++
Sbjct: 2094 QEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE-----FREQIHNLEDRLKKYEKN 2146
Score = 63.5 bits (153), Expect = 1e-09
Identities = 105/549 (19%), Positives = 224/549 (40%), Gaps = 82/549 (14%)
Query: 355 QLIEKFDQKPGLQRRGRSGKRNRINTDDRKRSRSV---DSAFPFGLQGNSEYLI--EFSR 409
QL+ + ++K ++G + +NT ++R R V + SE LI ++
Sbjct: 1654 QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAK 1713
Query: 410 NLGKSSEHLLRPSQVCP-----------QRPLSQERRGKQSVGRTFAKLQGAAHGASCAH 458
N+ +E SQ C QR L+++ + Q VG+ + + C +
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773
Query: 459 SRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSG 518
++++ E ++ +G ++ EE + ++ Q+ + G
Sbjct: 1774 QE--------RLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH----VEKEGG 1821
Query: 519 AKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQI---LYNYLKEGSTDNDDATK 575
I K + N ++ELT Q E+ K++ L + + ++ T
Sbjct: 1822 KNNIQAK--QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
Query: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQK---SKLTIEVAELQRQLQL 632
+ +EK+Q L+ + N+ + K L Q S + + +L+ +L
Sbjct: 1880 K-----YEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
Query: 633 EVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKME 692
+ +Q + +E R++ +L LR +H +++E L+K ++ + K++
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQELE--------------ILKKEYDQEREEKIK 1980
Query: 693 REQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA--KEEQE 750
+EQ E++ L ++ E ++ +++E I+E + Q+++ L+ +EE
Sbjct: 1981 QEQEDLELKH-NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETN 2039
Query: 751 DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
LL+K + LK +++ +D +E+ A+++ L+ +EE K
Sbjct: 2040 QLLKK----IAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK--------- 2086
Query: 811 NTSEQDQAGTEMRVKLLQEENEKLQGRS-EELERRVAQLQRQIEDLKGDEAKAKETLKKY 869
+ + KL QEEN + EL+ ++AQ I D K E + +E +
Sbjct: 2087 ----------KYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNL 2136
Query: 870 EGEIRQLEE 878
E +++ E+
Sbjct: 2137 EDRLKKYEK 2145
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 147 bits (372), Expect = 5e-35
Identities = 172/837 (20%), Positives = 358/837 (42%), Gaps = 91/837 (10%)
Query: 469 KVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFP 528
++L+ G ++ V++ K+ +V+T + L+ + KK+ +
Sbjct: 213 ELLQRPGIEDVAVLK--------KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYAS 264
Query: 529 S-ASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQT 587
S A+ +Q +L KG QE+ E K VN + +K QT
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQEL------------------QKLKSSVNELTQKNQT 306
Query: 588 LKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM 647
L Q + E K E SK I+ Q+ L Q ++
Sbjct: 307 LTENLLKKEQDYTKL-----EEKHNEESVSKKNIQATLHQKDLDC-----QQLQSRLSAS 356
Query: 648 RANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQL 707
+L + + +EK E L++ L E E + + E Q++ +RE+ + LQ ++
Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI 416
Query: 708 SEMHDELDSAKRSEDREKGAL-------IEELLQAKQDLQDLLIAKEEQEDLLRKREREL 760
+++H +L +R G L E+L+ +Q + DL + E+ L+++
Sbjct: 417 NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNS 476
Query: 761 TALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
T L+ L + H QE L++ A+L+ + +E+ + + + E +
Sbjct: 477 TELQHQLDKTKQQH-QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 821 EMRVKLLQEENEKLQGRSEELERRVA---QLQRQIEDLKGDEAKAKETLKKYEGEIRQLE 877
+ + LL++E E L + + E A QLQ + L+ + E LK +Q +
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 878 EALVHARKEEKEAVSARR----ALENELEAAQGNLSQTTQEQKQLSEKLKEESE------ 927
E L +E+K + A + +LE + L+++ ++ QL ++K ++E
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 655
Query: 928 ---------QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEY 978
+ L +N +++++ L K +L + A + + + +L++ L EY
Sbjct: 656 AAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS-QLESHLKEY 714
Query: 979 KEKN---RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKR 1035
KEK ++ E++ Q+K+ LEA+ + A K E+ L+D Q+ +
Sbjct: 715 KEKYLSLEQKTEELEGQIKK--LEADSLEVKASK--------EQALQDLQQQRQLNTDLE 764
Query: 1036 QLLEQTLKDLEYELEAKSHLKDD---RSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092
+ K LE E E S + D +S ++ ++ K+++ E E + + + + LS+
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ--- 821
Query: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152
++ Q E+L N + Q ++ +K +L + +K ++ + S ++SK + +
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
Query: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMK 1212
A + D ++ + + LQ+ ++ KEL ++ E + QL L L +M+
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE----KEASHQLKLELNSMQ 937
Query: 1213 RQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDD 1269
Q+ +A+ + + E +++LQ + E +E + Q+ +++ +L++ L L++
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
Score = 139 bits (350), Expect = 2e-32
Identities = 175/740 (23%), Positives = 343/740 (46%), Gaps = 143/740 (19%)
Query: 543 QQEL---TQQTNEETAK--------QILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSR 591
QQEL T Q ++ TAK L ++LKE + + ++K + +I+ L++
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK-EKYLSLEQKTEELEGQIKKLEAD 738
Query: 592 AAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANL 651
+ QA + + L + L + EL +QL++E + + + + ++ L
Sbjct: 739 SLEVKASKEQALQDLQQQRQL---NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 652 EELRSQHNEKVEENSTLQQRLE-----------ESEGELRKNLEELFQVKMEREQHQTEI 700
E ++ + ++ EE L+Q E E ++ + EL +VKME+E TE+
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 701 RDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKREREL 760
++D+LS++ D L ++K ++E +L ++ ++L + Q + K ++EL
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 761 TALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
K KE+ +SH Q EL +++E + +A NT +Q++
Sbjct: 916 K--KSLEKEKEASH---------QLKLELNSMQEQLIQA----------QNTLKQNE--- 951
Query: 821 EMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
+E ++LQG EL++ Q ++QIE L+G+ A L+K E E +L++ L
Sbjct: 952 --------KEEQQLQGNINELKQSSEQKKKQIEALQGELKIA--VLQKTELE-NKLQQQL 1000
Query: 881 VHARKE---EKEAVSAR-----------RALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
A +E EKE +S + L+++ + L T Q+ K + EKL S
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL---S 1057
Query: 927 EQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRREL 986
+E L +N++ N+ K I++L+ A + + S +LQ + ++
Sbjct: 1058 LAQEDLISNRNQIGNQ----NKLIQELKTAKATLEQDSAKKEQQLQERCKALQD------ 1107
Query: 987 AEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE 1046
+ ++ LKEK L EKS+L E+ + + Q++ +TK L + LK +
Sbjct: 1108 IQKEKSLKEKELVNEKSKLA-------------EIEEIKCRQEKEITK---LNEELKSHK 1151
Query: 1047 YE-LEAKSHLKDDRSRLVKQ---MEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLR 1102
E ++ ++LKD + L++Q ++ K L+ +E+E+ N +L +++ +++ E+L+
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV---KKEEEELK 1208
Query: 1103 NELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRL 1162
E +++ A K+ E + K++ + + ++ L +Q+ A L + L
Sbjct: 1209 KEFIEKEA--------KLHSEIKEKEVGMK------KHEENEAKLTMQITA----LNENL 1250
Query: 1163 ESEERDRANLQLSNRRLERKVKELVMQVDDEH-----LSLTDQKDQLSLRLKAMKRQVEE 1217
+ +++ + Q R+V EL Q DD L T Q +Q R A+ + +
Sbjct: 1251 GTVKKEWQSSQ-------RRVSELEKQTDDLRGEIAVLEATVQNNQDERR--ALLERCLK 1301
Query: 1218 AEEEIDRLESSKKKLQRELE 1237
E EI++L++ +LQR+L+
Sbjct: 1302 GEGEIEKLQTKVLELQRKLD 1321
Score = 129 bits (323), Expect = 2e-29
Identities = 153/738 (20%), Positives = 336/738 (45%), Gaps = 98/738 (13%)
Query: 598 GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ 657
GN+ S + + + L EV +LQ L+ E + +K+E E+ + L++ ++
Sbjct: 67 GNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG-LQQQEAK 125
Query: 658 HNEKVEENSTLQQRLEESEGELR------KNLEELFQVKMEREQHQTEIRDLQDQLSEMH 711
+ V ++S Q LE+ E + K +++LF+ K Q TEI D++ + E
Sbjct: 126 PDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQK--AAQLATEIADIKSKYDEER 183
Query: 712 DELDSAKR-----SEDREKGALI-----EELLQAKQDLQDLLIAKEE-------QEDLLR 754
++A++ +E+ K A + ELLQ + ++D+ + K+E +++
Sbjct: 184 SLREAAEQKVTRLTEELNKEATVIQDLKTELLQ-RPGIEDVAVLKKELVQVQTLMDNMTL 242
Query: 755 KRERELTALKG---ALKEEVSSHDQEMDKLKEQ----------YDAELQALRESVEEATK 801
+RERE LK L+ + +S + + +L+ + Y ELQ L+ SV E T+
Sbjct: 243 ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
Query: 802 NVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGR-------SEELERRVAQLQRQIED 854
+ L EQD E + + +Q ++L+ R++ + +
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 855 LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR-------ALENELEAAQGN 907
+ + ++ E +K + E+ ++E H + E K+ R L++E+
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 908 LSQTTQEQKQLSEKLKEESE-QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT 966
L +T ++ + +LKE+ + E+L + ++ + + L + E+L++++ T
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV--------T 474
Query: 967 STLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQR 1026
++ ELQ+QLD+ K++++ + A +Q+ K EA+ ++ + ++++++ +
Sbjct: 475 NSTELQHQLDKTKQQHQEQQA-LQQSTTAKLREAQNDLEQVLRQIGD---KDQKIQNLEA 530
Query: 1027 AQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDL 1086
++ LLE+ +DL +++A + + ++ Q+++K L+ E+ ++
Sbjct: 531 LLQKSKENISLLEKEREDLYAKIQA----GEGETAVLNQLQEKNHTLQ---EQVTQLTEK 583
Query: 1087 LSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEG 1146
L + ++ E L +++ +++A + + +SLE +L S++ +
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL----NESKEKVSQ 639
Query: 1147 LVVQMEARIAELEDRLESEERDRANLQ----LSNRRLERKVKELVMQVDDEHLSLTDQKD 1202
L +Q++A+ L ++ RA+LQ + L+ K +EL +T Q D
Sbjct: 640 LDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL--------NKITTQLD 691
Query: 1203 QLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKD-LRLKK 1261
Q++ +L ++ +E +LES K+ + + E L+GQ+ ++ D L +K
Sbjct: 692 QVTAKL-------QDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 1262 LPSKVLDDMDDDDDLSTD 1279
+ L D+ L+TD
Sbjct: 745 SKEQALQDLQQQRQLNTD 762
Score = 126 bits (317), Expect = 1e-28
Identities = 168/783 (21%), Positives = 345/783 (44%), Gaps = 98/783 (12%)
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
Q+++TQ T + + + +E D K + +++ +L++ N++
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 603 CNSTSEVKDLLEQKSKL--------TIEVAELQRQLQLEVKNQQNIKEERERMRANLEEL 654
S++ ++ K++L T + A+LQ L Q+ ++E ++ L+++
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
Query: 655 RSQHNEKVEENS--------------TLQQRLEESEGELRKNLEELFQVKMEREQHQTEI 700
++ +K E S +L+Q+ EE EG+++K + +VK +EQ +
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ---AL 750
Query: 701 RDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKREREL 760
+DLQ Q +++ +L+ ++ E + + DLQ A E + L K+E E
Sbjct: 751 QDLQQQ-RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE- 808
Query: 761 TALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
K LK++ + QE E+ + +Q +++ E L + +T + +
Sbjct: 809 ---KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865
Query: 821 EMRVKL----LQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQL 876
+K ++EN+K + +LE+ +L+ Q++ + + TLK E ++L
Sbjct: 866 SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ------VQMENTLK----EQKEL 915
Query: 877 EEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS---EKLKEESEQKEQLR 933
+++L ++ + +++ +L AQ L Q +E++QL +LK+ SEQK+
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK--- 972
Query: 934 RLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQL 993
K IE LQ E+ V EL+N+L + + +ELA + ++
Sbjct: 973 --------------KQIEALQGELKIAV----LQKTELENKLQQQLTQAAQELAAEKEKI 1014
Query: 994 KEKTLEAEKSRLTAMKMQDEMRLMEEEL-----------RDYQRAQDEALTKRQLLEQTL 1042
EKS+ T ++Q + E EL AQ++ ++ R +
Sbjct: 1015 SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN 1074
Query: 1043 KDLEYELEAKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRSREQMEQL 1101
K ++ AK+ L+ D ++ +Q++++ L +++ E+ +L++E+ + + +
Sbjct: 1075 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKC 1134
Query: 1102 RNE----LLQERAARQDLECDK--ISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARI 1155
R E L E LE K +L+ + L + + L+G S K V+ E R
Sbjct: 1135 RQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK--AAVEQEKRN 1192
Query: 1156 AE-LEDRLESEERDRANLQLSNR---RLERKVKELVMQVDDEH-LSLTDQKDQLSLRLKA 1210
+ L+D+++ EE + + E K KE+ M+ +E+ LT Q L+ L
Sbjct: 1193 QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 1211 MKRQVEEAEEEIDRLESSKKKLQRE---LEEQMDMNEHLQGQL--NSMKKDLRLKKLPSK 1265
+K++ + ++ + LE L+ E LE + N+ + L +K + ++KL +K
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK 1312
Query: 1266 VLD 1268
VL+
Sbjct: 1313 VLE 1315
Score = 116 bits (290), Expect = 2e-25
Identities = 133/626 (21%), Positives = 279/626 (44%), Gaps = 60/626 (9%)
Query: 710 MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE 769
+HD + + + +++ +Q++QDL + +E++ + ++EL +G ++
Sbjct: 63 VHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ 122
Query: 770 EVSSHDQEMDKLKEQYDAELQALRESVEEA-TKNVEV--------------------LAS 808
E D L AELQ+L + +EEA T+N + + S
Sbjct: 123 EAKP-----DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKS 177
Query: 809 RSNTSEQDQAGTEMRVKLLQEENEK----LQGRSEELERR-----VAQLQRQIEDL---- 855
+ + + E +V L EE K +Q EL +R VA L++++ +
Sbjct: 178 KYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLM 237
Query: 856 -------KGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908
+ + K K+ KK + + E + R E + EL+ + ++
Sbjct: 238 DNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSV 297
Query: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQ---KEMADIVEASR 965
++ TQ+ + L+E L ++ + +L NE + ++ T+ + +++ + AS
Sbjct: 298 NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASE 357
Query: 966 TSTLELQNQLDEYKE---KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELR 1022
TS + +L E E K + EL+E+ + K + L+AE +L + + E ++ +
Sbjct: 358 TSLHRIHVELSEKGEATQKLKEELSEV--ETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 1023 DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERN 1082
Q T+RQL E + L+ + + S D+ + V ++ K+S+LE +L+E+
Sbjct: 416 INQLHSKLLETERQLGEAHGR-LKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 1083 NSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 1142
NS L ++ ++++Q ++ + A ++ + D + RQ D +I +LE +
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
Query: 1143 SKEGLVVQMEARIAELEDRLESEERDRA---NLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
SKE + + +E +L ++++ E + A LQ N L+ +V +L ++ ++ S
Sbjct: 535 SKENISL-LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRL 1259
++ L +++ K + A++ + LE+S +L +L E + L Q+ + K +L L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA-KTELLL 652
Query: 1260 KKLPSKVLDDMDDDDDLSTDGGSLYE 1285
+K D + L T +L +
Sbjct: 653 SAEAAKTAQRADLQNHLDTAQNALQD 678
Score = 84.7 bits (208), Expect = 5e-16
Identities = 96/427 (22%), Positives = 193/427 (45%), Gaps = 50/427 (11%)
Query: 539 LLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQ-TLKSRAAGSAQ 597
L++ Q L Q EE Q N LK+ S + K+++ E +Q LK +
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSS----EQKKKQI----EALQGELKIAVLQKTE 991
Query: 598 GNNQACNS-TSEVKDLLEQKSKLTI------EVAELQRQLQLE--------VKNQQNIKE 642
N+ T ++L +K K+++ + E +QLQ + + +Q++K
Sbjct: 992 LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051
Query: 643 ERERMRANLEELRSQHNEKVEEN----------STLQQRLEESEGELRKNLEELFQVKME 692
E++ E+L S N+ +N +TL+Q + E +L++ + L ++ E
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111
Query: 693 REQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDL 752
+ + E+ + + +L+E ++ K +++E L EEL K + + ++ + L
Sbjct: 1112 KSLKEKELVNEKSKLAE----IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL 1167
Query: 753 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALR-ESVEEATKNVEVLASRS- 810
L +++ EL +LK V + LK+Q E + L+ E +E+ K + +
Sbjct: 1168 LIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227
Query: 811 --NTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKK 868
E+++A M++ L E ++ + +RRV++L++Q +DL+G+ A + T++
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 869 YEGEIRQLEEALVHARKE----EKEAVSARRALENELEAAQ----GNLSQTTQEQKQLSE 920
+ E R L E + E + + + +R L+N A Q N S + + L+
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNR 1347
Query: 921 KLKEESE 927
K E++E
Sbjct: 1348 KWAEDNE 1354
Score = 67.8 bits (164), Expect = 7e-11
Identities = 92/458 (20%), Positives = 198/458 (43%), Gaps = 60/458 (13%)
Query: 354 DQLIE-----KFDQKPGLQRRGRSGKRNRINTDDRKRSRSVDSAFPFGLQGNSEYLIEFS 408
+QLI+ K ++K Q +G + + + +K+ ++ + +E +
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
Query: 409 RNLGKSSEHLLRPSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHG--ASCAHSRPPQPNI 466
+ L ++++ L + +S + + TF +LQ +G + +R ++
Sbjct: 998 QQLTQAAQEL-----AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 467 DGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKT 526
+ K+ +QE + +G Q+K +E+KTA ATL DS K+ ++
Sbjct: 1053 EEKL---SLAQEDLISNRNQIGNQNKLIQELKTAKATL---------EQDSAKKEQQLQ- 1099
Query: 527 FPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQ 586
+A D+ K + ++ E +K +K + TK L K++
Sbjct: 1100 ----ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK--CRQEKEITKLNEELKSHKLE 1153
Query: 587 TLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQ----NIKE 642
++K + N + L++QK +L + L+ ++ E +NQQ +K+
Sbjct: 1154 SIK-----------EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
Query: 643 ERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNL----EELFQVKMEREQHQT 698
E E ++ E ++ + +++E ++ EE+E +L + E L VK E + Q
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262
Query: 699 EIRDLQDQLSEMHDE---LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK 755
+ +L+ Q ++ E L++ ++ E+ AL+E L+ + +++ L + + +L RK
Sbjct: 1263 RVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL---QTKVLELQRK 1319
Query: 756 RERELTALKGALKEEVS---SHDQEMDKLKEQYDAELQ 790
+ A++ +E S H Q +++ K D E+Q
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNR-KWAEDNEVQ 1356
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 147 bits (372), Expect = 5e-35
Identities = 173/769 (22%), Positives = 342/769 (44%), Gaps = 87/769 (11%)
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQ----G 598
Q+ L Q E+ ++ + G + +R+ L ++++ + A G+AQ
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAA 1711
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
+ +E + +Q+ L E+A LQR+ + +Q ++ E ++RA +E L +
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 659 NEKVEENSTL----QQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714
EE+ + +QRLE G R+ EE +++ E+ + + + ++ + E
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 715 DSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
+ EK A I E + K + + L KE + + LR+ + + L+E+ + H
Sbjct: 1832 ERVLA----EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887
Query: 775 ----DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEE 830
++ + +L++ D+EL+ + VE+ L R E+ + L+
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVEDT------LRQRRQVEEE--------ILALKAS 1933
Query: 831 NEKLQGRSEELERRVAQLQRQIED-LKGDE------AKAKETLKKYEGEIRQLEEALVHA 883
EK ELE + +++ ED L+ E A+ ++ + E R+ EE + +
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 884 RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL------RRLKN 937
E+EA R+A E+E L +E ++L E+ ++ES ++ QL +RL+
Sbjct: 1994 LAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 938 E-------MENERWHLGKTIEKLQKEMADI---VEASRTSTLELQN---QLDEYKEKNRR 984
E ++ + L +T+++ Q + + EA+R + E + Q + ++RR
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044
++ E +R LK+ E ++R A +++R E E +RAQ E RQ +
Sbjct: 2110 QVEEAER-LKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK-----QA 2162
Query: 1045 LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR-------EQ 1097
+ E+E + R Q+E +++ L ++LEE + +LL E + R + Q
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 1098 MEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE 1157
Q+ EL R ++L K +E +N+ L R + + R +E + ++AE
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEE--AEKMKQVAE 2278
Query: 1158 LEDRLESEERDRANL-QLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
RL ++ A L QL+ L ++ + L ++ E + + +L + +++Q E
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 1217 EAEEEIDRLESSKKKLQRELEE-----QMDMNEHLQGQLNSMKKDLRLK 1260
A+E+ RL+ K+++ ++L E Q + Q QL + RLK
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Score = 134 bits (337), Expect = 6e-31
Identities = 166/742 (22%), Positives = 318/742 (42%), Gaps = 84/742 (11%)
Query: 572 DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEV-----KDLLEQKSKLTIEVAEL 626
+A KV E + K+RA ++ ++ E ++L E+ ++L E
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 627 QRQLQLEVKNQQNIKEERERMRAN-LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEE 685
+RQ QL ++ + E ER+ A L + K E L+++ E+E R +E
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873
Query: 686 LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745
FQ + EQ D++++L+++ DS +R+KG + + L Q +Q +++L
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILAL 1930
Query: 746 KEEQEDLLRKR---ERELTALKGALKEEVSSHDQ-EMDKLKE-QYDAELQALRESVEEAT 800
K E + E EL ++ ++ + S +Q E++ ++ Q AE + R EE
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 801 KNVEVLASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIED--LK 856
+ + LA+ + Q +A E R+K EE +L+ R+E+ R QL ++ L+
Sbjct: 1991 Q--KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2048
Query: 857 GDEAKAKETLKKYEGEIRQL---EEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ 913
+E +++ E E++Q E++++ + E EA ARRA E EA + Q
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQ 2106
Query: 914 EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS-----T 968
++Q+ E+ E+L++ E R EKL+KE EA+R +
Sbjct: 2107 SRRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAA 2156
Query: 969 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 1028
L + D EK+++ + RQ + E RL + + L++EEL+ +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLK----------------------DDRSRLVKQM 1066
EA +R +E+ L + ++E S LK + + +KQ+
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126
++ ++L + +E L E +++ R E++ E +Q L+ + L++Q
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 1127 KDLKSRIIHLEGSYRSSKEGLV-----------------VQMEARIAELEDRLESEERDR 1169
+ + + L+ + L ++M A L+ R+ R +
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 1170 ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQ----VEEAEEEIDRL 1225
A + +R ++ +E+ ++ L+ T +K L L+ ++Q E E I L
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455
Query: 1226 ESSKKKLQRELEEQMDMNEHLQ 1247
E K+KLQ+E + +E +Q
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQ 2477
Score = 133 bits (335), Expect = 1e-30
Identities = 198/906 (21%), Positives = 374/906 (41%), Gaps = 141/906 (15%)
Query: 483 RAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKG 542
R + A +K+ ++ A A Q A ++ V+ +A + Q ++
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 543 Q-QELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQ 601
+ Q+L Q + E + E S + R V L E + R G A+G Q
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE----RQRGGAEGELQ 1476
Query: 602 ACNSTSEV-----KDLLEQKSKLTIEVA-ELQRQLQLEVKNQQNIKEE----RERMRA-- 649
A + +E + E+ +L +V E QR+ Q EV+ +K E RE+ RA
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 650 NLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSE 709
LEELR Q E ++RL ++E E + + QV +E Q E +LQ + +
Sbjct: 1537 ALEELRLQAEEA-------ERRLRQAEVERARQV----QVALETAQRSAEA-ELQSKRAS 1584
Query: 710 MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK- 768
++ +RS E A+ + +A++ Q A+ +E+ R+ ER AL+
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 769 ----EEVSSHDQ----EMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
EEV+ E +K KE+ + E + ++ E+A + E+ Q GT
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 821 EMRVKLLQEENEKLQGRSEE-------LERRVAQLQRQI-------EDLKGDEA------ 860
+ ++E +L+ +E+ LE +A+LQR+ ++L+ + A
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 861 -------------------KAKETLKKYEGEIRQL-----------EEALVHARKEEKEA 890
K+K+ L+ G R+L EEA + E++A
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 891 VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
R E L + + T+ + + LKE+ + E+LRRL E+E + +
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLE 1881
Query: 951 EKLQKEMADIVE------ASRTSTLELQNQLDEYKEKNRREL------------------ 986
E+ + ADI E + S LE Q L E + RR++
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 987 AEMQRQL--------------KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEAL 1032
AE++ +L ++ LEA + R A + + R EE ++ A++EA
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 1033 TKRQLLEQTLKDLEYELEAKSHLK---DDRSRLVKQMEDKVSQLEMELEEE------RNN 1083
+R+ + ++ L+ ++E L+ + S Q+ + +Q ++ EE+ +
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 1084 SDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSS 1143
L + + + + ++QLR E R A ++ E ++ ER+ + ++ E +S+
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 1144 KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERK-VKELVMQVDDEHLSLT-DQK 1201
+E + +A+ A + R E+E+ Q L +K + M+ + T QK
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 1202 DQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL-RLK 1260
Q+ L ++ Q+EE + + + L+ ++L+ E E ++ +L S++ + L
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 1261 KLPSKV 1266
KL +++
Sbjct: 2242 KLKARI 2247
Score = 132 bits (332), Expect = 2e-30
Identities = 166/726 (22%), Positives = 321/726 (44%), Gaps = 101/726 (13%)
Query: 574 TKRKVNLVFEKIQTLKSR----AAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629
T R+ V E+I LK+ AAG A+ + S +D L K + +E A QRQ
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1974
Query: 630 LQLEVKNQQNIKEER----------------------ERMRANLEELRSQHNEKVEENST 667
L E + ++ EER ER++A +EE R + E+ E+ S
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR-RLRERAEQESA 2033
Query: 668 LQQRLEESEGELRKNLEE---LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Q +L + + R EE F V+ + ++ Q ++ Q L ++ E ++A+R+ +
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Query: 725 KGALIE---ELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV------SSHD 775
+ A ++ E Q+++ +++ K+ E+ + R + A + KE + +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 776 QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Q + K+ DAE++ ++ E+ + + T T+ + LL EE ++L+
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 836 GRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR 895
+ E R+ +Q++ ++ ++ E L K + I AL+ K+ +
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEE 2269
Query: 896 ALENELEAAQG-NLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQ 954
A + + A + LS QE +L + +E+ Q+ R L +M E+ + +L+
Sbjct: 2270 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ---RALAEKMLKEKMQAVQEATRLK 2326
Query: 955 KEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE- 1013
E A++++ + E +L E KE+ ++LAE + Q ++TLEAE+ R M + E
Sbjct: 2327 AE-AELLQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1014 MRLMEEEL-RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQ 1072
++L E+ R RA+++A R+ E E+ K H R+ L Q +KV+
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAE--------EIGEKLH----RTELATQ--EKVT- 2429
Query: 1073 LEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSR 1132
L LE +R SD +ER+ + ++E+ + +L QE ++
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE----------------------AK 2467
Query: 1133 IIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD 1192
++ L+ S+E VQ E + E + +S ++ +L R +E++ +L D
Sbjct: 2468 LLQLK-----SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 1193 EHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
E +++ +RQ ++ E+E RL +S ++ +R E + Q +L
Sbjct: 2523 EVAKAQQLREE-------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 1253 MKKDLR 1258
+++ R
Sbjct: 2576 LEQQRR 2581
Score = 110 bits (275), Expect = 9e-24
Identities = 176/850 (20%), Positives = 355/850 (41%), Gaps = 92/850 (10%)
Query: 427 QRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPS 486
++ L Q + +QSV +L+G A A A + + E E +Q +
Sbjct: 2062 EQELQQTLQQEQSV---LDQLRGEAEAARRAAEEAEEARVQA---EREAAQSRRQVEEAE 2115
Query: 487 LGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLK----G 542
QS +E+ A A + + + A++ + A ++ K
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
+Q L Q+ E L L+E T + NL+ E++Q LK+ A +A+ +Q
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Query: 603 CNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKN--QQNIKEERERMRANLEELRSQHNE 660
V+ +E+ SKL + R L L K+ Q+ ++EE E+M+ EE ++ +
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSV 2285
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS 720
+E + L+Q EE + R E++ + KM+ Q T ++ + L + + R
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 721 EDREKGALIEELLQAKQDLQDLLIAKEEQE-------DLLRKRERELTALKGALKEEVSS 773
+K + ++L + Q Q L A+ +++ + L+ R E++ + +E+
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA-- 2403
Query: 774 HDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
Q K E+ +L + +E V+ L + S+ D + L+ E EK
Sbjct: 2404 --QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
LQ ++ L+ + ++Q + E +ET + + + + L R E+E
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQ-----EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 894 RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL 953
+ ++E+ AQ + ++Q+Q+ ++ + E+ RR ++E E + +++L
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 954 QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ-----RQLKEKTL---------- 998
+++ E L+ QL +E++R LA + + KTL
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2636
Query: 999 --EAE--------KSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
EAE + +++A ++Q+ L EEL QR T +L + +D+ +
Sbjct: 2637 AAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQGHTTVDELARR--EDVRHY 2691
Query: 1049 LEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQLR--- 1102
L+ +S + L+K +K+S L+ +L + +L E + S ++ +R
Sbjct: 2692 LQGRSSI---AGLLLKATNEKLSVYAALQRQLLSP-GTALILLEAQAASGFLLDPVRNRR 2747
Query: 1103 ---NELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS-YRSSKEGLVVQ------ME 1152
NE ++E +L +S ER K + S +++ ++GL+V+ +E
Sbjct: 2748 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLE 2807
Query: 1153 ARIAELEDRLESEERDRANLQLSNRR--LERKVKELVMQVDDEHLSLTDQKDQLSLR-LK 1209
A+IA ++ R + ++ RR + ++ ++ D+ D +L L+
Sbjct: 2808 AQIA-TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQ 2866
Query: 1210 AMKRQVEEAE 1219
++R VE+ E
Sbjct: 2867 LLERCVEDPE 2876
Score = 97.8 bits (242), Expect = 6e-20
Identities = 166/811 (20%), Positives = 342/811 (42%), Gaps = 75/811 (9%)
Query: 481 VIRAPSLGA-QSKKEEEVKTATATLMLQNRA-TATSPDSGAKKISVKTFPSASNTQATPD 538
+IR+ SL ++ K EE + A +L L +A S D+G + +
Sbjct: 905 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 964
Query: 539 LLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG 598
+ Q L Q EE+ Q + LK+ + R V+ + ++ K A AQ
Sbjct: 965 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL--RLPLDKEPARECAQR 1022
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ- 657
+ + +EV+ L + ++L+ E AE L ++ E E LE++RS
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAE-AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1081
Query: 658 --HNEKVEENSTLQQRLEESEGELRKNLEELFQVKM------EREQHQTEIRDLQDQLSE 709
+ EK++ S + + + +E LR + E+L + + E E + ++ L+ Q
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 710 MHDELDSAKRSEDREKGAL-IEELLQAKQDLQDLLIAK--EEQEDLLRK----------R 756
D+ + D +GA + E LQ + +D+ + + E LL + R
Sbjct: 1142 QQPTFDALR---DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1198
Query: 757 ERELTALKGALKEEVSSHD------QEMDKLKEQYDA----ELQALRESVEEATKNVEVL 806
+REL L L+ S D Q+ + +EQ A + QA+RE + + +E +
Sbjct: 1199 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI 1258
Query: 807 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE-- 864
E+ Q + + +++ +L +LE VA ++ + G E+ +E
Sbjct: 1259 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYV 1317
Query: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
L+ + E+ L + E R +E E A+ Q++ + E+L E
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISE------TLRRMEEEERLAE-------QQRAEERERLAE 1364
Query: 925 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 984
E+ R+L + + ++LQ+ M + V + ++ Q Q +E+ ++
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044
+ +++ K +AE + + +++++E+R++ +L +R + A + Q L ++
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484
Query: 1045 LEYELEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQL 1101
E + K +++ RL +Q++D+ Q E+EL + R+ + +E+L
Sbjct: 1485 AEAQ---KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 1102 RNELLQERAARQDLECDK-----ISLERQNKDLKSRIIHLEGSY---RSSKEGLVVQMEA 1153
R + + + E ++ ++LE + ++ + S+ + E + +
Sbjct: 1542 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1601
Query: 1154 RIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDE---HLSLTDQKDQLSLRLKA 1210
+A+L + E + +A + + ER+++ ++ ++ L + Q SL
Sbjct: 1602 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1661
Query: 1211 MKRQVEEAEEEIDRLESSKKKL--QRELEEQ 1239
++Q EEAE E R ++++ QREL EQ
Sbjct: 1662 AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Score = 97.1 bits (240), Expect = 1e-19
Identities = 192/920 (20%), Positives = 384/920 (41%), Gaps = 104/920 (11%)
Query: 398 QGNSEYLIEFSRNLGKSSEHLLRPSQVCPQRPLSQERRGKQSVGRT--FAKLQGAAH-GA 454
Q E L E+ +L ++ Q+ P+ P + RG+ + + +++ H G
Sbjct: 768 QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGD 826
Query: 455 SCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLG-AQSKKEEEVKTATATLMLQNRATAT 513
C P QP+ KVL + GS+ + PS+ +E + A L Q++A T
Sbjct: 827 ECQLVGPAQPS-HWKVLSSSGSEAAV----PSVCFLVPPPNQEAQEAVTRLEAQHQALVT 881
Query: 514 SPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQT-NEETAKQILYN---YLKEGSTD 569
+ +K+ + + + L++ T +T E +Q L++ + + D
Sbjct: 882 LWHQ--LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 939
Query: 570 NDDA----------TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDL---LEQK 616
+ DA +R+ Q L AQ ++ SE+KD+ LE
Sbjct: 940 SQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEAC 999
Query: 617 SKLTIEVAELQ------RQLQLEVKNQQNIKEERERMRANLEELRSQHN------EKVEE 664
T+ L R+ + QQ + E E + + L ++ E
Sbjct: 1000 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1059
Query: 665 NSTLQQRLEESEGELRKNLEELFQVKMER-EQHQTEIRDLQ--DQLSEMHDELDSAKRSE 721
TL+ LE + G+L + + L + +E+ + IR Q +++ H+E + E
Sbjct: 1060 APTLRSELELTLGKLEQ-VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE----QLKE 1114
Query: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
+ A + EL K L+ L E Q+ AL++E+ + ++L
Sbjct: 1115 AQAVPATLPELEATKASLKKLRAQAEAQQPTF-----------DALRDELRGAQEVGERL 1163
Query: 782 KEQY---DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
++++ D E++ RE V + + + + ++++ +++ +++ +E + L
Sbjct: 1164 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1223
Query: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE---EALVHARKEEKEAVSARR 895
++ RR Q+Q D +E L++ + + ++E E + ++ K+ ++A +
Sbjct: 1224 QDARRRQEQIQAMP---LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK 1280
Query: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE--QLRRLKNEMENERWHLGKTIEKL 953
E +L + L K+ + ES +E LR +E+ K I +
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 954 QKEMAD---IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 1010
+ M + + E R E +++ EK +R+LAE Q K + E E L +M
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA-EREAKELQ-QRM 1397
Query: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD--DRSRLVKQMED 1068
Q+E+ EE D AQ + + ++ L+Q + E E++AK+ + +RSRL + E
Sbjct: 1398 QEEVVRREEAAVD---AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 1069 KVSQLEMEL-EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
+V +L++E E +R ++ + + E+ E Q+R A+++ E + ++ +++
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEA------QKRQAQEEAERLRRQVQDESQ 1508
Query: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRR-------LE 1180
+ + L ++ E + A A E RL++EE +R Q R LE
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 1181 RKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDR-------LESSKKKLQ 1233
+ ++ + S ++ QL L+ V + EE +R E ++++ +
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Query: 1234 RELEE-QMDMNEHLQGQLNS 1252
RELE Q+ NE L+ +L +
Sbjct: 1629 RELERWQLKANEALRLRLQA 1648
Score = 62.8 bits (151), Expect = 2e-09
Identities = 115/507 (22%), Positives = 215/507 (42%), Gaps = 66/507 (13%)
Query: 775 DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKL 834
D+E + Q AE Q + VE K V L++ + +V L E +
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-----------KVLALPEPSPAA 1060
Query: 835 QGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIR--QLEEALVHARKEEKEAVS 892
ELE + +L E ++ A E LK IR Q E ++ A +E+ +
Sbjct: 1061 PTLRSELELTLGKL----EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116
Query: 893 ARRALENELEAAQGNLSQTTQEQKQ-------LSEKLKEESEQKEQLRRLKNE--MENER 943
A A ELEA + +L + + + L ++L+ E E+L++ E +E ER
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 944 WH--LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ----RQLKEKT 997
W + + +E+ Q +A + + +L QL Y+E A +Q RQ + +
Sbjct: 1177 WRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Query: 998 LEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLK 1056
+ S+ +++ E L+EE R ++ ++ +Q + +KD E +L K+ L+
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN-AIKDYELQLVTYKAQLE 1294
Query: 1057 DDRSRL----VKQMEDKVSQLEMELEEERNNSDLLSER----ISRSREQMEQLRNELLQE 1108
S V+ + V Q ++L + L+ + IS + +ME+ Q+
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 1109 RAA-RQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER 1167
RA R+ L + +LE+Q + L ++ +K Q E EL+ R++ E
Sbjct: 1355 RAEERERLAEVEAALEKQRQ--------LAEAHAQAK----AQAEREAKELQQRMQEEVV 1402
Query: 1168 DRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLES 1227
R + ++ +R ++E + Q+ Q + ++ KA RQ E AE R+E
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLR--------QSSEAEIQAKA--RQAEAAERSRLRIEE 1452
Query: 1228 SKKKLQRELEEQMDMNEHLQGQLNSMK 1254
+ ++ +LE +G+L +++
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALR 1479
Score = 40.4 bits (93), Expect = 0.011
Identities = 90/409 (22%), Positives = 157/409 (38%), Gaps = 79/409 (19%)
Query: 914 EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK-LQKEMADIVEASRTSTLELQ 972
E+++ +E Q + K EME K K + + + V+A +
Sbjct: 303 EERRFPSSFEEIEILWSQFLKFK-EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGY 361
Query: 973 NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM-----KMQDEMRLMEEELR----- 1022
+ LD KE + +A ++R EK L +E RL + K+Q E L EE+L
Sbjct: 362 HPLDVEKEWGKLHVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADAL 418
Query: 1023 ------------------DYQRAQDEALTKRQLL---EQTLKD----------------- 1044
+ +R D+A + +LL QTLKD
Sbjct: 419 LQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH 478
Query: 1045 -------LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE--RNNSDLLS------E 1089
EY L K+ + ++ V Q+ + Q ELE+ R DLL+
Sbjct: 479 ERLVAIRTEYNLRLKAGVAAPATQ-VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQH 537
Query: 1090 RISRSR--EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
R+ + + + +L R Q +E + +ER D G+YR L
Sbjct: 538 RVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRL 597
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRL----ERKVKELVMQVDDEHLSLTDQKDQ 1203
+Q + + RL S E + + + + L E++ +E+ D + ++T +K+
Sbjct: 598 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657
Query: 1204 LSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
S A+ R++E E++I L+++ +L RE E Q L +
Sbjct: 658 YS----ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 702
Score = 31.2 bits (69), Expect = 6.8
Identities = 77/356 (21%), Positives = 135/356 (37%), Gaps = 48/356 (13%)
Query: 564 KEGSTDND-DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLL-----EQKS 617
+ G + D D + L+F +QTLK G Q + + L E
Sbjct: 434 RAGEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNL 490
Query: 618 KLTIEVAELQRQL-QLEVKNQQNIKEERERMRANLEEL-----RSQHNEKVEENSTLQQR 671
+L VA Q+ Q+ +++ Q E + L++L +QH E
Sbjct: 491 RLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPS 550
Query: 672 LEESEGE---LRKNLEELFQVKMEREQHQT---------EIRDLQDQLSEMHDELDSAKR 719
+E G L +++EE F+ K+ER + RD +L + +L ++ +
Sbjct: 551 VEAQLGSHRGLHQSIEE-FRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 609
Query: 720 SEDREKGALIEELLQAKQDLQDLLIAKEEQEDL-LRKRERELTALKGALKEEVSSHDQEM 778
+ R +L + A ++L L +EE+ R +TA K + + + +
Sbjct: 610 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 669
Query: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSE--------------QDQAGTEMRV 824
K+KE +A + LRE A VE + T ++ A
Sbjct: 670 KKIKELQNAGDRLLRED-HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 728
Query: 825 KLLQEENEKLQGRSEELERRVA----QLQRQIEDLKGDEAKAKETLKKYEGEIRQL 876
++E +LQ E L R+ + ++EDL D KE L +Y+G + L
Sbjct: 729 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL 784
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 147 bits (372), Expect = 5e-35
Identities = 173/769 (22%), Positives = 342/769 (44%), Gaps = 87/769 (11%)
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQ----G 598
Q+ L Q E+ ++ + G + +R+ L ++++ + A G+AQ
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAA 1715
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
+ +E + +Q+ L E+A LQR+ + +Q ++ E ++RA +E L +
Sbjct: 1716 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775
Query: 659 NEKVEENSTL----QQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714
EE+ + +QRLE G R+ EE +++ E+ + + + ++ + E
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 715 DSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
+ EK A I E + K + + L KE + + LR+ + + L+E+ + H
Sbjct: 1836 ERVLA----EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1891
Query: 775 ----DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEE 830
++ + +L++ D+EL+ + VE+ L R E+ + L+
Sbjct: 1892 KADIEERLAQLRKASDSELERQKGLVEDT------LRQRRQVEEE--------ILALKAS 1937
Query: 831 NEKLQGRSEELERRVAQLQRQIED-LKGDE------AKAKETLKKYEGEIRQLEEALVHA 883
EK ELE + +++ ED L+ E A+ ++ + E R+ EE + +
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1997
Query: 884 RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL------RRLKN 937
E+EA R+A E+E L +E ++L E+ ++ES ++ QL +RL+
Sbjct: 1998 LAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053
Query: 938 E-------MENERWHLGKTIEKLQKEMADI---VEASRTSTLELQN---QLDEYKEKNRR 984
E ++ + L +T+++ Q + + EA+R + E + Q + ++RR
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113
Query: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044
++ E +R LK+ E ++R A +++R E E +RAQ E RQ +
Sbjct: 2114 QVEEAER-LKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK-----QA 2166
Query: 1045 LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR-------EQ 1097
+ E+E + R Q+E +++ L ++LEE + +LL E + R + Q
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226
Query: 1098 MEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE 1157
Q+ EL R ++L K +E +N+ L R + + R +E + ++AE
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEE--AEKMKQVAE 2282
Query: 1158 LEDRLESEERDRANL-QLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
RL ++ A L QL+ L ++ + L ++ E + + +L + +++Q E
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2341
Query: 1217 EAEEEIDRLESSKKKLQRELEE-----QMDMNEHLQGQLNSMKKDLRLK 1260
A+E+ RL+ K+++ ++L E Q + Q QL + RLK
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390
Score = 134 bits (337), Expect = 6e-31
Identities = 166/742 (22%), Positives = 318/742 (42%), Gaps = 84/742 (11%)
Query: 572 DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEV-----KDLLEQKSKLTIEVAEL 626
+A KV E + K+RA ++ ++ E ++L E+ ++L E
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1817
Query: 627 QRQLQLEVKNQQNIKEERERMRAN-LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEE 685
+RQ QL ++ + E ER+ A L + K E L+++ E+E R +E
Sbjct: 1818 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1877
Query: 686 LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745
FQ + EQ D++++L+++ DS +R+KG + + L Q +Q +++L
Sbjct: 1878 AFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILAL 1934
Query: 746 KEEQEDLLRKR---ERELTALKGALKEEVSSHDQ-EMDKLKE-QYDAELQALRESVEEAT 800
K E + E EL ++ ++ + S +Q E++ ++ Q AE + R EE
Sbjct: 1935 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1994
Query: 801 KNVEVLASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIED--LK 856
+ + LA+ + Q +A E R+K EE +L+ R+E+ R QL ++ L+
Sbjct: 1995 Q--KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2052
Query: 857 GDEAKAKETLKKYEGEIRQL---EEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ 913
+E +++ E E++Q E++++ + E EA ARRA E EA + Q
Sbjct: 2053 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQ 2110
Query: 914 EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS-----T 968
++Q+ E+ E+L++ E R EKL+KE EA+R +
Sbjct: 2111 SRRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAA 2160
Query: 969 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 1028
L + D EK+++ + RQ + E RL + + L++EEL+ +
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLK----------------------DDRSRLVKQM 1066
EA +R +E+ L + ++E S LK + + +KQ+
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280
Query: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126
++ ++L + +E L E +++ R E++ E +Q L+ + L++Q
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340
Query: 1127 KDLKSRIIHLEGSYRSSKEGLV-----------------VQMEARIAELEDRLESEERDR 1169
+ + + L+ + L ++M A L+ R+ R +
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 1170 ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQ----VEEAEEEIDRL 1225
A + +R ++ +E+ ++ L+ T +K L L+ ++Q E E I L
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2459
Query: 1226 ESSKKKLQRELEEQMDMNEHLQ 1247
E K+KLQ+E + +E +Q
Sbjct: 2460 EREKEKLQQEAKLLQLKSEEMQ 2481
Score = 133 bits (335), Expect = 1e-30
Identities = 198/906 (21%), Positives = 374/906 (41%), Gaps = 141/906 (15%)
Query: 483 RAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKG 542
R + A +K+ ++ A A Q A ++ V+ +A + Q ++
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424
Query: 543 Q-QELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQ 601
+ Q+L Q + E + E S + R V L E + R G A+G Q
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE----RQRGGAEGELQ 1480
Query: 602 ACNSTSEV-----KDLLEQKSKLTIEVA-ELQRQLQLEVKNQQNIKEE----RERMRA-- 649
A + +E + E+ +L +V E QR+ Q EV+ +K E RE+ RA
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 650 NLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSE 709
LEELR Q E ++RL ++E E + + QV +E Q E +LQ + +
Sbjct: 1541 ALEELRLQAEEA-------ERRLRQAEVERARQV----QVALETAQRSAEA-ELQSKRAS 1588
Query: 710 MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK- 768
++ +RS E A+ + +A++ Q A+ +E+ R+ ER AL+
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1648
Query: 769 ----EEVSSHDQ----EMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
EEV+ E +K KE+ + E + ++ E+A + E+ Q GT
Sbjct: 1649 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 821 EMRVKLLQEENEKLQGRSEE-------LERRVAQLQRQI-------EDLKGDEA------ 860
+ ++E +L+ +E+ LE +A+LQR+ ++L+ + A
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768
Query: 861 -------------------KAKETLKKYEGEIRQL-----------EEALVHARKEEKEA 890
K+K+ L+ G R+L EEA + E++A
Sbjct: 1769 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1828
Query: 891 VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
R E L + + T+ + + LKE+ + E+LRRL E+E + +
Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLE 1885
Query: 951 EKLQKEMADIVE------ASRTSTLELQNQLDEYKEKNRREL------------------ 986
E+ + ADI E + S LE Q L E + RR++
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Query: 987 AEMQRQL--------------KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEAL 1032
AE++ +L ++ LEA + R A + + R EE ++ A++EA
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 1033 TKRQLLEQTLKDLEYELEAKSHLK---DDRSRLVKQMEDKVSQLEMELEEE------RNN 1083
+R+ + ++ L+ ++E L+ + S Q+ + +Q ++ EE+ +
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 1084 SDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSS 1143
L + + + + ++QLR E R A ++ E ++ ER+ + ++ E +S+
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 1144 KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERK-VKELVMQVDDEHLSLT-DQK 1201
+E + +A+ A + R E+E+ Q L +K + M+ + T QK
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185
Query: 1202 DQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL-RLK 1260
Q+ L ++ Q+EE + + + L+ ++L+ E E ++ +L S++ + L
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245
Query: 1261 KLPSKV 1266
KL +++
Sbjct: 2246 KLKARI 2251
Score = 132 bits (332), Expect = 2e-30
Identities = 166/726 (22%), Positives = 321/726 (44%), Gaps = 101/726 (13%)
Query: 574 TKRKVNLVFEKIQTLKSR----AAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629
T R+ V E+I LK+ AAG A+ + S +D L K + +E A QRQ
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1978
Query: 630 LQLEVKNQQNIKEER----------------------ERMRANLEELRSQHNEKVEENST 667
L E + ++ EER ER++A +EE R + E+ E+ S
Sbjct: 1979 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR-RLRERAEQESA 2037
Query: 668 LQQRLEESEGELRKNLEE---LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Q +L + + R EE F V+ + ++ Q ++ Q L ++ E ++A+R+ +
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097
Query: 725 KGALIE---ELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV------SSHD 775
+ A ++ E Q+++ +++ K+ E+ + R + A + KE + +
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157
Query: 776 QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Q + K+ DAE++ ++ E+ + + T T+ + LL EE ++L+
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217
Query: 836 GRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR 895
+ E R+ +Q++ ++ ++ E L K + I AL+ K+ +
Sbjct: 2218 AEATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEE 2273
Query: 896 ALENELEAAQG-NLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQ 954
A + + A + LS QE +L + +E+ Q+ R L +M E+ + +L+
Sbjct: 2274 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ---RALAEKMLKEKMQAVQEATRLK 2330
Query: 955 KEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE- 1013
E A++++ + E +L E KE+ ++LAE + Q ++TLEAE+ R M + E
Sbjct: 2331 AE-AELLQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 1014 MRLMEEEL-RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQ 1072
++L E+ R RA+++A R+ E E+ K H R+ L Q +KV+
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAE--------EIGEKLH----RTELATQ--EKVT- 2433
Query: 1073 LEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSR 1132
L LE +R SD +ER+ + ++E+ + +L QE ++
Sbjct: 2434 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE----------------------AK 2471
Query: 1133 IIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD 1192
++ L+ S+E VQ E + E + +S ++ +L R +E++ +L D
Sbjct: 2472 LLQLK-----SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526
Query: 1193 EHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
E +++ +RQ ++ E+E RL +S ++ +R E + Q +L
Sbjct: 2527 EVAKAQQLREE-------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579
Query: 1253 MKKDLR 1258
+++ R
Sbjct: 2580 LEQQRR 2585
Score = 110 bits (275), Expect = 9e-24
Identities = 176/850 (20%), Positives = 355/850 (41%), Gaps = 92/850 (10%)
Query: 427 QRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPS 486
++ L Q + +QSV +L+G A A A + + E E +Q +
Sbjct: 2066 EQELQQTLQQEQSV---LDQLRGEAEAARRAAEEAEEARVQA---EREAAQSRRQVEEAE 2119
Query: 487 LGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLK----G 542
QS +E+ A A + + + A++ + A ++ K
Sbjct: 2120 RLKQSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
+Q L Q+ E L L+E T + NL+ E++Q LK+ A +A+ +Q
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAEATEAARQRSQV 2230
Query: 603 CNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKN--QQNIKEERERMRANLEELRSQHNE 660
V+ +E+ SKL + R L L K+ Q+ ++EE E+M+ EE ++ +
Sbjct: 2231 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSV 2289
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS 720
+E + L+Q EE + R E++ + KM+ Q T ++ + L + + R
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 721 EDREKGALIEELLQAKQDLQDLLIAKEEQE-------DLLRKRERELTALKGALKEEVSS 773
+K + ++L + Q Q L A+ +++ + L+ R E++ + +E+
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA-- 2407
Query: 774 HDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
Q K E+ +L + +E V+ L + S+ D + L+ E EK
Sbjct: 2408 --QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2465
Query: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
LQ ++ L+ + ++Q + E +ET + + + + L R E+E
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQ-----EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 894 RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL 953
+ ++E+ AQ + ++Q+Q+ ++ + E+ RR ++E E + +++L
Sbjct: 2521 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2580
Query: 954 QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ-----RQLKEKTL---------- 998
+++ E L+ QL +E++R LA + + KTL
Sbjct: 2581 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2640
Query: 999 --EAE--------KSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
EAE + +++A ++Q+ L EEL QR T +L + +D+ +
Sbjct: 2641 AAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQGHTTVDELARR--EDVRHY 2695
Query: 1049 LEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQLR--- 1102
L+ +S + L+K +K+S L+ +L + +L E + S ++ +R
Sbjct: 2696 LQGRSSI---AGLLLKATNEKLSVYAALQRQLLSP-GTALILLEAQAASGFLLDPVRNRR 2751
Query: 1103 ---NELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS-YRSSKEGLVVQ------ME 1152
NE ++E +L +S ER K + S +++ ++GL+V+ +E
Sbjct: 2752 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLE 2811
Query: 1153 ARIAELEDRLESEERDRANLQLSNRR--LERKVKELVMQVDDEHLSLTDQKDQLSLR-LK 1209
A+IA ++ R + ++ RR + ++ ++ D+ D +L L+
Sbjct: 2812 AQIA-TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQ 2870
Query: 1210 AMKRQVEEAE 1219
++R VE+ E
Sbjct: 2871 LLERCVEDPE 2880
Score = 97.8 bits (242), Expect = 6e-20
Identities = 166/811 (20%), Positives = 342/811 (42%), Gaps = 75/811 (9%)
Query: 481 VIRAPSLGA-QSKKEEEVKTATATLMLQNRA-TATSPDSGAKKISVKTFPSASNTQATPD 538
+IR+ SL ++ K EE + A +L L +A S D+G + +
Sbjct: 909 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 968
Query: 539 LLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG 598
+ Q L Q EE+ Q + LK+ + R V+ + ++ K A AQ
Sbjct: 969 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL--RLPLDKEPARECAQR 1026
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ- 657
+ + +EV+ L + ++L+ E AE L ++ E E LE++RS
Sbjct: 1027 IAEQQKAQAEVEGLGKGVARLSAE-AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1085
Query: 658 --HNEKVEENSTLQQRLEESEGELRKNLEELFQVKM------EREQHQTEIRDLQDQLSE 709
+ EK++ S + + + +E LR + E+L + + E E + ++ L+ Q
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145
Query: 710 MHDELDSAKRSEDREKGAL-IEELLQAKQDLQDLLIAK--EEQEDLLRK----------R 756
D+ + D +GA + E LQ + +D+ + + E LL + R
Sbjct: 1146 QQPTFDALR---DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1202
Query: 757 ERELTALKGALKEEVSSHD------QEMDKLKEQYDA----ELQALRESVEEATKNVEVL 806
+REL L L+ S D Q+ + +EQ A + QA+RE + + +E +
Sbjct: 1203 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI 1262
Query: 807 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE-- 864
E+ Q + + +++ +L +LE VA ++ + G E+ +E
Sbjct: 1263 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYV 1321
Query: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
L+ + E+ L + E R +E E A+ Q++ + E+L E
Sbjct: 1322 DLRTHYSELTTLTSQYIKFISE------TLRRMEEEERLAE-------QQRAEERERLAE 1368
Query: 925 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 984
E+ R+L + + ++LQ+ M + V + ++ Q Q +E+ ++
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1428
Query: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044
+ +++ K +AE + + +++++E+R++ +L +R + A + Q L ++
Sbjct: 1429 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1488
Query: 1045 LEYELEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQL 1101
E + K +++ RL +Q++D+ Q E+EL + R+ + +E+L
Sbjct: 1489 AEAQ---KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1545
Query: 1102 RNELLQERAARQDLECDK-----ISLERQNKDLKSRIIHLEGSY---RSSKEGLVVQMEA 1153
R + + + E ++ ++LE + ++ + S+ + E + +
Sbjct: 1546 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1605
Query: 1154 RIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDE---HLSLTDQKDQLSLRLKA 1210
+A+L + E + +A + + ER+++ ++ ++ L + Q SL
Sbjct: 1606 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1665
Query: 1211 MKRQVEEAEEEIDRLESSKKKL--QRELEEQ 1239
++Q EEAE E R ++++ QREL EQ
Sbjct: 1666 AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Score = 97.1 bits (240), Expect = 1e-19
Identities = 192/920 (20%), Positives = 384/920 (41%), Gaps = 104/920 (11%)
Query: 398 QGNSEYLIEFSRNLGKSSEHLLRPSQVCPQRPLSQERRGKQSVGRT--FAKLQGAAH-GA 454
Q E L E+ +L ++ Q+ P+ P + RG+ + + +++ H G
Sbjct: 772 QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGD 830
Query: 455 SCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLG-AQSKKEEEVKTATATLMLQNRATAT 513
C P QP+ KVL + GS+ + PS+ +E + A L Q++A T
Sbjct: 831 ECQLVGPAQPS-HWKVLSSSGSEAAV----PSVCFLVPPPNQEAQEAVTRLEAQHQALVT 885
Query: 514 SPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQT-NEETAKQILYN---YLKEGSTD 569
+ +K+ + + + L++ T +T E +Q L++ + + D
Sbjct: 886 LWHQ--LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 943
Query: 570 NDDA----------TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDL---LEQK 616
+ DA +R+ Q L AQ ++ SE+KD+ LE
Sbjct: 944 SQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEAC 1003
Query: 617 SKLTIEVAELQ------RQLQLEVKNQQNIKEERERMRANLEELRSQHN------EKVEE 664
T+ L R+ + QQ + E E + + L ++ E
Sbjct: 1004 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1063
Query: 665 NSTLQQRLEESEGELRKNLEELFQVKMER-EQHQTEIRDLQ--DQLSEMHDELDSAKRSE 721
TL+ LE + G+L + + L + +E+ + IR Q +++ H+E + E
Sbjct: 1064 APTLRSELELTLGKLEQ-VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE----QLKE 1118
Query: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
+ A + EL K L+ L E Q+ AL++E+ + ++L
Sbjct: 1119 AQAVPATLPELEATKASLKKLRAQAEAQQPTF-----------DALRDELRGAQEVGERL 1167
Query: 782 KEQY---DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
++++ D E++ RE V + + + + ++++ +++ +++ +E + L
Sbjct: 1168 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1227
Query: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE---EALVHARKEEKEAVSARR 895
++ RR Q+Q D +E L++ + + ++E E + ++ K+ ++A +
Sbjct: 1228 QDARRRQEQIQAMP---LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK 1284
Query: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE--QLRRLKNEMENERWHLGKTIEKL 953
E +L + L K+ + ES +E LR +E+ K I +
Sbjct: 1285 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344
Query: 954 QKEMAD---IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 1010
+ M + + E R E +++ EK +R+LAE Q K + E E L +M
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA-EREAKELQ-QRM 1401
Query: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD--DRSRLVKQMED 1068
Q+E+ EE D AQ + + ++ L+Q + E E++AK+ + +RSRL + E
Sbjct: 1402 QEEVVRREEAAVD---AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
Query: 1069 KVSQLEMEL-EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
+V +L++E E +R ++ + + E+ E Q+R A+++ E + ++ +++
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEA------QKRQAQEEAERLRRQVQDESQ 1512
Query: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRR-------LE 1180
+ + L ++ E + A A E RL++EE +R Q R LE
Sbjct: 1513 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1572
Query: 1181 RKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDR-------LESSKKKLQ 1233
+ ++ + S ++ QL L+ V + EE +R E ++++ +
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632
Query: 1234 RELEE-QMDMNEHLQGQLNS 1252
RELE Q+ NE L+ +L +
Sbjct: 1633 RELERWQLKANEALRLRLQA 1652
Score = 62.8 bits (151), Expect = 2e-09
Identities = 115/507 (22%), Positives = 215/507 (42%), Gaps = 66/507 (13%)
Query: 775 DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKL 834
D+E + Q AE Q + VE K V L++ + +V L E +
Sbjct: 1016 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-----------KVLALPEPSPAA 1064
Query: 835 QGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIR--QLEEALVHARKEEKEAVS 892
ELE + +L E ++ A E LK IR Q E ++ A +E+ +
Sbjct: 1065 PTLRSELELTLGKL----EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1120
Query: 893 ARRALENELEAAQGNLSQTTQEQKQ-------LSEKLKEESEQKEQLRRLKNE--MENER 943
A A ELEA + +L + + + L ++L+ E E+L++ E +E ER
Sbjct: 1121 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1180
Query: 944 WH--LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ----RQLKEKT 997
W + + +E+ Q +A + + +L QL Y+E A +Q RQ + +
Sbjct: 1181 WRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1239
Query: 998 LEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLK 1056
+ S+ +++ E L+EE R ++ ++ +Q + +KD E +L K+ L+
Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN-AIKDYELQLVTYKAQLE 1298
Query: 1057 DDRSRL----VKQMEDKVSQLEMELEEERNNSDLLSER----ISRSREQMEQLRNELLQE 1108
S V+ + V Q ++L + L+ + IS + +ME+ Q+
Sbjct: 1299 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1358
Query: 1109 RAA-RQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER 1167
RA R+ L + +LE+Q + L ++ +K Q E EL+ R++ E
Sbjct: 1359 RAEERERLAEVEAALEKQRQ--------LAEAHAQAK----AQAEREAKELQQRMQEEVV 1406
Query: 1168 DRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLES 1227
R + ++ +R ++E + Q+ Q + ++ KA RQ E AE R+E
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLR--------QSSEAEIQAKA--RQAEAAERSRLRIEE 1456
Query: 1228 SKKKLQRELEEQMDMNEHLQGQLNSMK 1254
+ ++ +LE +G+L +++
Sbjct: 1457 EIRVVRLQLEATERQRGGAEGELQALR 1483
Score = 40.4 bits (93), Expect = 0.011
Identities = 90/409 (22%), Positives = 157/409 (38%), Gaps = 79/409 (19%)
Query: 914 EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK-LQKEMADIVEASRTSTLELQ 972
E+++ +E Q + K EME K K + + + V+A +
Sbjct: 307 EERRFPSSFEEIEILWSQFLKFK-EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGY 365
Query: 973 NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM-----KMQDEMRLMEEELR----- 1022
+ LD KE + +A ++R EK L +E RL + K+Q E L EE+L
Sbjct: 366 HPLDVEKEWGKLHVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADAL 422
Query: 1023 ------------------DYQRAQDEALTKRQLL---EQTLKD----------------- 1044
+ +R D+A + +LL QTLKD
Sbjct: 423 LQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH 482
Query: 1045 -------LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE--RNNSDLLS------E 1089
EY L K+ + ++ V Q+ + Q ELE+ R DLL+
Sbjct: 483 ERLVAIRTEYNLRLKAGVAAPATQ-VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQH 541
Query: 1090 RISRSR--EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
R+ + + + +L R Q +E + +ER D G+YR L
Sbjct: 542 RVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRL 601
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRL----ERKVKELVMQVDDEHLSLTDQKDQ 1203
+Q + + RL S E + + + + L E++ +E+ D + ++T +K+
Sbjct: 602 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 661
Query: 1204 LSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
S A+ R++E E++I L+++ +L RE E Q L +
Sbjct: 662 YS----ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 706
Score = 31.2 bits (69), Expect = 6.8
Identities = 77/356 (21%), Positives = 135/356 (37%), Gaps = 48/356 (13%)
Query: 564 KEGSTDND-DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLL-----EQKS 617
+ G + D D + L+F +QTLK G Q + + L E
Sbjct: 438 RAGEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNL 494
Query: 618 KLTIEVAELQRQL-QLEVKNQQNIKEERERMRANLEEL-----RSQHNEKVEENSTLQQR 671
+L VA Q+ Q+ +++ Q E + L++L +QH E
Sbjct: 495 RLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPS 554
Query: 672 LEESEGE---LRKNLEELFQVKMEREQHQT---------EIRDLQDQLSEMHDELDSAKR 719
+E G L +++EE F+ K+ER + RD +L + +L ++ +
Sbjct: 555 VEAQLGSHRGLHQSIEE-FRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 613
Query: 720 SEDREKGALIEELLQAKQDLQDLLIAKEEQEDL-LRKRERELTALKGALKEEVSSHDQEM 778
+ R +L + A ++L L +EE+ R +TA K + + + +
Sbjct: 614 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 673
Query: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSE--------------QDQAGTEMRV 824
K+KE +A + LRE A VE + T ++ A
Sbjct: 674 KKIKELQNAGDRLLRED-HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 732
Query: 825 KLLQEENEKLQGRSEELERRVA----QLQRQIEDLKGDEAKAKETLKKYEGEIRQL 876
++E +LQ E L R+ + ++EDL D KE L +Y+G + L
Sbjct: 733 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL 788
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 147 bits (372), Expect = 5e-35
Identities = 173/769 (22%), Positives = 342/769 (44%), Gaps = 87/769 (11%)
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQ----G 598
Q+ L Q E+ ++ + G + +R+ L ++++ + A G+AQ
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE--LAEQELEKQRQLAEGTAQQRLAA 1711
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
+ +E + +Q+ L E+A LQR+ + +Q ++ E ++RA +E L +
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 659 NEKVEENSTL----QQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714
EE+ + +QRLE G R+ EE +++ E+ + + + ++ + E
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 715 DSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
+ EK A I E + K + + L KE + + LR+ + + L+E+ + H
Sbjct: 1832 ERVLA----EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887
Query: 775 ----DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEE 830
++ + +L++ D+EL+ + VE+ L R E+ + L+
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVEDT------LRQRRQVEEE--------ILALKAS 1933
Query: 831 NEKLQGRSEELERRVAQLQRQIED-LKGDE------AKAKETLKKYEGEIRQLEEALVHA 883
EK ELE + +++ ED L+ E A+ ++ + E R+ EE + +
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 884 RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL------RRLKN 937
E+EA R+A E+E L +E ++L E+ ++ES ++ QL +RL+
Sbjct: 1994 LAAEEEAARQRKAALEEVE----RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 938 E-------MENERWHLGKTIEKLQKEMADI---VEASRTSTLELQN---QLDEYKEKNRR 984
E ++ + L +T+++ Q + + EA+R + E + Q + ++RR
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044
++ E +R LK+ E ++R A +++R E E +RAQ E RQ +
Sbjct: 2110 QVEEAER-LKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK-----QA 2162
Query: 1045 LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR-------EQ 1097
+ E+E + R Q+E +++ L ++LEE + +LL E + R + Q
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 1098 MEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE 1157
Q+ EL R ++L K +E +N+ L R + + R +E + ++AE
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEE--AEKMKQVAE 2278
Query: 1158 LEDRLESEERDRANL-QLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
RL ++ A L QL+ L ++ + L ++ E + + +L + +++Q E
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 1217 EAEEEIDRLESSKKKLQRELEE-----QMDMNEHLQGQLNSMKKDLRLK 1260
A+E+ RL+ K+++ ++L E Q + Q QL + RLK
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Score = 134 bits (337), Expect = 6e-31
Identities = 166/742 (22%), Positives = 318/742 (42%), Gaps = 84/742 (11%)
Query: 572 DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEV-----KDLLEQKSKLTIEVAEL 626
+A KV E + K+RA ++ ++ E ++L E+ ++L E
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 627 QRQLQLEVKNQQNIKEERERMRAN-LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEE 685
+RQ QL ++ + E ER+ A L + K E L+++ E+E R +E
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873
Query: 686 LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745
FQ + EQ D++++L+++ DS +R+KG + + L Q +Q +++L
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSEL---ERQKGLVEDTLRQRRQVEEEILAL 1930
Query: 746 KEEQEDLLRKR---ERELTALKGALKEEVSSHDQ-EMDKLKE-QYDAELQALRESVEEAT 800
K E + E EL ++ ++ + S +Q E++ ++ Q AE + R EE
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 801 KNVEVLASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIED--LK 856
+ + LA+ + Q +A E R+K EE +L+ R+E+ R QL ++ L+
Sbjct: 1991 Q--KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2048
Query: 857 GDEAKAKETLKKYEGEIRQL---EEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ 913
+E +++ E E++Q E++++ + E EA ARRA E EA + Q
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQ 2106
Query: 914 EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS-----T 968
++Q+ E+ E+L++ E R EKL+KE EA+R +
Sbjct: 2107 SRRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAA 2156
Query: 969 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 1028
L + D EK+++ + RQ + E RL + + L++EEL+ +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLK----------------------DDRSRLVKQM 1066
EA +R +E+ L + ++E S LK + + +KQ+
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126
++ ++L + +E L E +++ R E++ E +Q L+ + L++Q
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 1127 KDLKSRIIHLEGSYRSSKEGLV-----------------VQMEARIAELEDRLESEERDR 1169
+ + + L+ + L ++M A L+ R+ R +
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 1170 ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQ----VEEAEEEIDRL 1225
A + +R ++ +E+ ++ L+ T +K L L+ ++Q E E I L
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455
Query: 1226 ESSKKKLQRELEEQMDMNEHLQ 1247
E K+KLQ+E + +E +Q
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQ 2477
Score = 133 bits (335), Expect = 1e-30
Identities = 198/906 (21%), Positives = 374/906 (41%), Gaps = 141/906 (15%)
Query: 483 RAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKG 542
R + A +K+ ++ A A Q A ++ V+ +A + Q ++
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 543 Q-QELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQ 601
+ Q+L Q + E + E S + R V L E + R G A+G Q
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE----RQRGGAEGELQ 1476
Query: 602 ACNSTSEV-----KDLLEQKSKLTIEVA-ELQRQLQLEVKNQQNIKEE----RERMRA-- 649
A + +E + E+ +L +V E QR+ Q EV+ +K E RE+ RA
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 650 NLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSE 709
LEELR Q E ++RL ++E E + + QV +E Q E +LQ + +
Sbjct: 1537 ALEELRLQAEEA-------ERRLRQAEVERARQV----QVALETAQRSAEA-ELQSKRAS 1584
Query: 710 MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK- 768
++ +RS E A+ + +A++ Q A+ +E+ R+ ER AL+
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 769 ----EEVSSHDQ----EMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
EEV+ E +K KE+ + E + ++ E+A + E+ Q GT
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 821 EMRVKLLQEENEKLQGRSEE-------LERRVAQLQRQI-------EDLKGDEA------ 860
+ ++E +L+ +E+ LE +A+LQR+ ++L+ + A
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 861 -------------------KAKETLKKYEGEIRQL-----------EEALVHARKEEKEA 890
K+K+ L+ G R+L EEA + E++A
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 891 VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
R E L + + T+ + + LKE+ + E+LRRL E+E + +
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLE 1881
Query: 951 EKLQKEMADIVE------ASRTSTLELQNQLDEYKEKNRREL------------------ 986
E+ + ADI E + S LE Q L E + RR++
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 987 AEMQRQL--------------KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEAL 1032
AE++ +L ++ LEA + R A + + R EE ++ A++EA
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 1033 TKRQLLEQTLKDLEYELEAKSHLK---DDRSRLVKQMEDKVSQLEMELEEE------RNN 1083
+R+ + ++ L+ ++E L+ + S Q+ + +Q ++ EE+ +
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 1084 SDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSS 1143
L + + + + ++QLR E R A ++ E ++ ER+ + ++ E +S+
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 1144 KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERK-VKELVMQVDDEHLSLT-DQK 1201
+E + +A+ A + R E+E+ Q L +K + M+ + T QK
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 1202 DQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL-RLK 1260
Q+ L ++ Q+EE + + + L+ ++L+ E E ++ +L S++ + L
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 1261 KLPSKV 1266
KL +++
Sbjct: 2242 KLKARI 2247
Score = 132 bits (332), Expect = 2e-30
Identities = 166/726 (22%), Positives = 321/726 (44%), Gaps = 101/726 (13%)
Query: 574 TKRKVNLVFEKIQTLKSR----AAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629
T R+ V E+I LK+ AAG A+ + S +D L K + +E A QRQ
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1974
Query: 630 LQLEVKNQQNIKEER----------------------ERMRANLEELRSQHNEKVEENST 667
L E + ++ EER ER++A +EE R + E+ E+ S
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR-RLRERAEQESA 2033
Query: 668 LQQRLEESEGELRKNLEE---LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Q +L + + R EE F V+ + ++ Q ++ Q L ++ E ++A+R+ +
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Query: 725 KGALIE---ELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV------SSHD 775
+ A ++ E Q+++ +++ K+ E+ + R + A + KE + +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 776 QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Q + K+ DAE++ ++ E+ + + T T+ + LL EE ++L+
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 836 GRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR 895
+ E R+ +Q++ ++ ++ E L K + I AL+ K+ +
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEE 2269
Query: 896 ALENELEAAQG-NLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQ 954
A + + A + LS QE +L + +E+ Q+ R L +M E+ + +L+
Sbjct: 2270 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ---RALAEKMLKEKMQAVQEATRLK 2326
Query: 955 KEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE- 1013
E A++++ + E +L E KE+ ++LAE + Q ++TLEAE+ R M + E
Sbjct: 2327 AE-AELLQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1014 MRLMEEEL-RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQ 1072
++L E+ R RA+++A R+ E E+ K H R+ L Q +KV+
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAE--------EIGEKLH----RTELATQ--EKVT- 2429
Query: 1073 LEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSR 1132
L LE +R SD +ER+ + ++E+ + +L QE ++
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE----------------------AK 2467
Query: 1133 IIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD 1192
++ L+ S+E VQ E + E + +S ++ +L R +E++ +L D
Sbjct: 2468 LLQLK-----SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 1193 EHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
E +++ +RQ ++ E+E RL +S ++ +R E + Q +L
Sbjct: 2523 EVAKAQQLREE-------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 1253 MKKDLR 1258
+++ R
Sbjct: 2576 LEQQRR 2581
Score = 110 bits (275), Expect = 9e-24
Identities = 176/850 (20%), Positives = 355/850 (41%), Gaps = 92/850 (10%)
Query: 427 QRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPS 486
++ L Q + +QSV +L+G A A A + + E E +Q +
Sbjct: 2062 EQELQQTLQQEQSV---LDQLRGEAEAARRAAEEAEEARVQA---EREAAQSRRQVEEAE 2115
Query: 487 LGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLK----G 542
QS +E+ A A + + + A++ + A ++ K
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
+Q L Q+ E L L+E T + NL+ E++Q LK+ A +A+ +Q
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEE--------TDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Query: 603 CNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKN--QQNIKEERERMRANLEELRSQHNE 660
V+ +E+ SKL + R L L K+ Q+ ++EE E+M+ EE ++ +
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSV 2285
Query: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS 720
+E + L+Q EE + R E++ + KM+ Q T ++ + L + + R
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 721 EDREKGALIEELLQAKQDLQDLLIAKEEQE-------DLLRKRERELTALKGALKEEVSS 773
+K + ++L + Q Q L A+ +++ + L+ R E++ + +E+
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA-- 2403
Query: 774 HDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
Q K E+ +L + +E V+ L + S+ D + L+ E EK
Sbjct: 2404 --QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
LQ ++ L+ + ++Q + E +ET + + + + L R E+E
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQ-----EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 894 RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL 953
+ ++E+ AQ + ++Q+Q+ ++ + E+ RR ++E E + +++L
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 954 QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ-----RQLKEKTL---------- 998
+++ E L+ QL +E++R LA + + KTL
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2636
Query: 999 --EAE--------KSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
EAE + +++A ++Q+ L EEL QR T +L + +D+ +
Sbjct: 2637 AAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQGHTTVDELARR--EDVRHY 2691
Query: 1049 LEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQLR--- 1102
L+ +S + L+K +K+S L+ +L + +L E + S ++ +R
Sbjct: 2692 LQGRSSI---AGLLLKATNEKLSVYAALQRQLLSP-GTALILLEAQAASGFLLDPVRNRR 2747
Query: 1103 ---NELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS-YRSSKEGLVVQ------ME 1152
NE ++E +L +S ER K + S +++ ++GL+V+ +E
Sbjct: 2748 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLE 2807
Query: 1153 ARIAELEDRLESEERDRANLQLSNRR--LERKVKELVMQVDDEHLSLTDQKDQLSLR-LK 1209
A+IA ++ R + ++ RR + ++ ++ D+ D +L L+
Sbjct: 2808 AQIA-TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQ 2866
Query: 1210 AMKRQVEEAE 1219
++R VE+ E
Sbjct: 2867 LLERCVEDPE 2876
Score = 97.8 bits (242), Expect = 6e-20
Identities = 166/811 (20%), Positives = 342/811 (42%), Gaps = 75/811 (9%)
Query: 481 VIRAPSLGA-QSKKEEEVKTATATLMLQNRA-TATSPDSGAKKISVKTFPSASNTQATPD 538
+IR+ SL ++ K EE + A +L L +A S D+G + +
Sbjct: 905 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 964
Query: 539 LLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG 598
+ Q L Q EE+ Q + LK+ + R V+ + ++ K A AQ
Sbjct: 965 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL--RLPLDKEPARECAQR 1022
Query: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ- 657
+ + +EV+ L + ++L+ E AE L ++ E E LE++RS
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAE-AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1081
Query: 658 --HNEKVEENSTLQQRLEESEGELRKNLEELFQVKM------EREQHQTEIRDLQDQLSE 709
+ EK++ S + + + +E LR + E+L + + E E + ++ L+ Q
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 710 MHDELDSAKRSEDREKGAL-IEELLQAKQDLQDLLIAK--EEQEDLLRK----------R 756
D+ + D +GA + E LQ + +D+ + + E LL + R
Sbjct: 1142 QQPTFDALR---DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1198
Query: 757 ERELTALKGALKEEVSSHD------QEMDKLKEQYDA----ELQALRESVEEATKNVEVL 806
+REL L L+ S D Q+ + +EQ A + QA+RE + + +E +
Sbjct: 1199 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI 1258
Query: 807 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE-- 864
E+ Q + + +++ +L +LE VA ++ + G E+ +E
Sbjct: 1259 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYV 1317
Query: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
L+ + E+ L + E R +E E A+ Q++ + E+L E
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISE------TLRRMEEEERLAE-------QQRAEERERLAE 1364
Query: 925 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 984
E+ R+L + + ++LQ+ M + V + ++ Q Q +E+ ++
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044
+ +++ K +AE + + +++++E+R++ +L +R + A + Q L ++
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484
Query: 1045 LEYELEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQL 1101
E + K +++ RL +Q++D+ Q E+EL + R+ + +E+L
Sbjct: 1485 AEAQ---KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 1102 RNELLQERAARQDLECDK-----ISLERQNKDLKSRIIHLEGSY---RSSKEGLVVQMEA 1153
R + + + E ++ ++LE + ++ + S+ + E + +
Sbjct: 1542 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1601
Query: 1154 RIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDE---HLSLTDQKDQLSLRLKA 1210
+A+L + E + +A + + ER+++ ++ ++ L + Q SL
Sbjct: 1602 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1661
Query: 1211 MKRQVEEAEEEIDRLESSKKKL--QRELEEQ 1239
++Q EEAE E R ++++ QREL EQ
Sbjct: 1662 AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Score = 97.1 bits (240), Expect = 1e-19
Identities = 192/920 (20%), Positives = 384/920 (41%), Gaps = 104/920 (11%)
Query: 398 QGNSEYLIEFSRNLGKSSEHLLRPSQVCPQRPLSQERRGKQSVGRT--FAKLQGAAH-GA 454
Q E L E+ +L ++ Q+ P+ P + RG+ + + +++ H G
Sbjct: 768 QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGD 826
Query: 455 SCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLG-AQSKKEEEVKTATATLMLQNRATAT 513
C P QP+ KVL + GS+ + PS+ +E + A L Q++A T
Sbjct: 827 ECQLVGPAQPS-HWKVLSSSGSEAAV----PSVCFLVPPPNQEAQEAVTRLEAQHQALVT 881
Query: 514 SPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQT-NEETAKQILYN---YLKEGSTD 569
+ +K+ + + + L++ T +T E +Q L++ + + D
Sbjct: 882 LWHQ--LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 939
Query: 570 NDDA----------TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDL---LEQK 616
+ DA +R+ Q L AQ ++ SE+KD+ LE
Sbjct: 940 SQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEAC 999
Query: 617 SKLTIEVAELQ------RQLQLEVKNQQNIKEERERMRANLEELRSQHN------EKVEE 664
T+ L R+ + QQ + E E + + L ++ E
Sbjct: 1000 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1059
Query: 665 NSTLQQRLEESEGELRKNLEELFQVKMER-EQHQTEIRDLQ--DQLSEMHDELDSAKRSE 721
TL+ LE + G+L + + L + +E+ + IR Q +++ H+E + E
Sbjct: 1060 APTLRSELELTLGKLEQ-VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE----QLKE 1114
Query: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
+ A + EL K L+ L E Q+ AL++E+ + ++L
Sbjct: 1115 AQAVPATLPELEATKASLKKLRAQAEAQQPTF-----------DALRDELRGAQEVGERL 1163
Query: 782 KEQY---DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
++++ D E++ RE V + + + + ++++ +++ +++ +E + L
Sbjct: 1164 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1223
Query: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE---EALVHARKEEKEAVSARR 895
++ RR Q+Q D +E L++ + + ++E E + ++ K+ ++A +
Sbjct: 1224 QDARRRQEQIQAMP---LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK 1280
Query: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE--QLRRLKNEMENERWHLGKTIEKL 953
E +L + L K+ + ES +E LR +E+ K I +
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 954 QKEMAD---IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 1010
+ M + + E R E +++ EK +R+LAE Q K + E E L +M
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA-EREAKELQ-QRM 1397
Query: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD--DRSRLVKQMED 1068
Q+E+ EE D AQ + + ++ L+Q + E E++AK+ + +RSRL + E
Sbjct: 1398 QEEVVRREEAAVD---AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 1069 KVSQLEMEL-EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
+V +L++E E +R ++ + + E+ E Q+R A+++ E + ++ +++
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEA------QKRQAQEEAERLRRQVQDESQ 1508
Query: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRR-------LE 1180
+ + L ++ E + A A E RL++EE +R Q R LE
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 1181 RKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDR-------LESSKKKLQ 1233
+ ++ + S ++ QL L+ V + EE +R E ++++ +
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Query: 1234 RELEE-QMDMNEHLQGQLNS 1252
RELE Q+ NE L+ +L +
Sbjct: 1629 RELERWQLKANEALRLRLQA 1648
Score = 62.8 bits (151), Expect = 2e-09
Identities = 115/507 (22%), Positives = 215/507 (42%), Gaps = 66/507 (13%)
Query: 775 DQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKL 834
D+E + Q AE Q + VE K V L++ + +V L E +
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-----------KVLALPEPSPAA 1060
Query: 835 QGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIR--QLEEALVHARKEEKEAVS 892
ELE + +L E ++ A E LK IR Q E ++ A +E+ +
Sbjct: 1061 PTLRSELELTLGKL----EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116
Query: 893 ARRALENELEAAQGNLSQTTQEQKQ-------LSEKLKEESEQKEQLRRLKNE--MENER 943
A A ELEA + +L + + + L ++L+ E E+L++ E +E ER
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 944 WH--LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ----RQLKEKT 997
W + + +E+ Q +A + + +L QL Y+E A +Q RQ + +
Sbjct: 1177 WRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Query: 998 LEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLK 1056
+ S+ +++ E L+EE R ++ ++ +Q + +KD E +L K+ L+
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN-AIKDYELQLVTYKAQLE 1294
Query: 1057 DDRSRL----VKQMEDKVSQLEMELEEERNNSDLLSER----ISRSREQMEQLRNELLQE 1108
S V+ + V Q ++L + L+ + IS + +ME+ Q+
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 1109 RAA-RQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER 1167
RA R+ L + +LE+Q + L ++ +K Q E EL+ R++ E
Sbjct: 1355 RAEERERLAEVEAALEKQRQ--------LAEAHAQAK----AQAEREAKELQQRMQEEVV 1402
Query: 1168 DRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLES 1227
R + ++ +R ++E + Q+ Q + ++ KA RQ E AE R+E
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLR--------QSSEAEIQAKA--RQAEAAERSRLRIEE 1452
Query: 1228 SKKKLQRELEEQMDMNEHLQGQLNSMK 1254
+ ++ +LE +G+L +++
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALR 1479
Score = 40.4 bits (93), Expect = 0.011
Identities = 90/409 (22%), Positives = 157/409 (38%), Gaps = 79/409 (19%)
Query: 914 EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK-LQKEMADIVEASRTSTLELQ 972
E+++ +E Q + K EME K K + + + V+A +
Sbjct: 303 EERRFPSSFEEIEILWSQFLKFK-EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGY 361
Query: 973 NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM-----KMQDEMRLMEEELR----- 1022
+ LD KE + +A ++R EK L +E RL + K+Q E L EE+L
Sbjct: 362 HPLDVEKEWGKLHVAILER---EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADAL 418
Query: 1023 ------------------DYQRAQDEALTKRQLL---EQTLKD----------------- 1044
+ +R D+A + +LL QTLKD
Sbjct: 419 LQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH 478
Query: 1045 -------LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE--RNNSDLLS------E 1089
EY L K+ + ++ V Q+ + Q ELE+ R DLL+
Sbjct: 479 ERLVAIRTEYNLRLKAGVAAPATQ-VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQH 537
Query: 1090 RISRSR--EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
R+ + + + +L R Q +E + +ER D G+YR L
Sbjct: 538 RVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRL 597
Query: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRL----ERKVKELVMQVDDEHLSLTDQKDQ 1203
+Q + + RL S E + + + + L E++ +E+ D + ++T +K+
Sbjct: 598 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657
Query: 1204 LSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
S A+ R++E E++I L+++ +L RE E Q L +
Sbjct: 658 YS----ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 702
Score = 31.2 bits (69), Expect = 6.8
Identities = 77/356 (21%), Positives = 135/356 (37%), Gaps = 48/356 (13%)
Query: 564 KEGSTDND-DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLL-----EQKS 617
+ G + D D + L+F +QTLK G Q + + L E
Sbjct: 434 RAGEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNL 490
Query: 618 KLTIEVAELQRQL-QLEVKNQQNIKEERERMRANLEEL-----RSQHNEKVEENSTLQQR 671
+L VA Q+ Q+ +++ Q E + L++L +QH E
Sbjct: 491 RLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPS 550
Query: 672 LEESEGE---LRKNLEELFQVKMEREQHQT---------EIRDLQDQLSEMHDELDSAKR 719
+E G L +++EE F+ K+ER + RD +L + +L ++ +
Sbjct: 551 VEAQLGSHRGLHQSIEE-FRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 609
Query: 720 SEDREKGALIEELLQAKQDLQDLLIAKEEQEDL-LRKRERELTALKGALKEEVSSHDQEM 778
+ R +L + A ++L L +EE+ R +TA K + + + +
Sbjct: 610 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 669
Query: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSE--------------QDQAGTEMRV 824
K+KE +A + LRE A VE + T ++ A
Sbjct: 670 KKIKELQNAGDRLLRED-HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 728
Query: 825 KLLQEENEKLQGRSEELERRVA----QLQRQIEDLKGDEAKAKETLKKYEGEIRQL 876
++E +LQ E L R+ + ++EDL D KE L +Y+G + L
Sbjct: 729 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL 784
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.125 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,094,951
Number of Sequences: 37866
Number of extensions: 2459556
Number of successful extensions: 53550
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 868
Number of HSP's successfully gapped in prelim test: 1696
Number of HSP's that attempted gapping in prelim test: 12462
Number of HSP's gapped (non-prelim): 13787
length of query: 1302
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1188
effective length of database: 13,930,794
effective search space: 16549783272
effective search space used: 16549783272
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.