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Search of human proteins with 31657092
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31657092 ATP binding cassette, sub-family A (ABC1), member
13 [Homo sapiens]
(5058 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 1.008e+04 0.0
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 1454 0.0
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 1454 0.0
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 1073 0.0
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 1036 0.0
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 980 0.0
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 514 e-145
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 514 e-145
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 424 e-117
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 415 e-115
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 299 5e-80
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 299 5e-80
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 274 2e-72
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 261 2e-68
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 259 4e-68
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 148 2e-34
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 148 2e-34
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 148 2e-34
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s... 89 1e-16
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa... 89 1e-16
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 88 2e-16
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 88 2e-16
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 88 2e-16
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 87 5e-16
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 87 5e-16
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 87 5e-16
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 87 5e-16
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 87 5e-16
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 87 5e-16
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s... 86 9e-16
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 1.008e+04 bits (26159), Expect = 0.0
Identities = 5058/5058 (100%), Positives = 5058/5058 (100%)
Query: 1 MGHAGCQFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPR 60
MGHAGCQFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPR
Sbjct: 1 MGHAGCQFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPR 60
Query: 61 DLPSCGVIPFVQSLLCNTGSRCRNFSYEGSMEHHFRLSRFQTAADPKKVNNLAFLKEIQD 120
DLPSCGVIPFVQSLLCNTGSRCRNFSYEGSMEHHFRLSRFQTAADPKKVNNLAFLKEIQD
Sbjct: 61 DLPSCGVIPFVQSLLCNTGSRCRNFSYEGSMEHHFRLSRFQTAADPKKVNNLAFLKEIQD 120
Query: 121 LAEEIHGMMDKAKNLKRLWVERSNTPDSSYGSSFFTMDLNKTEEVILKLESLHQQPHIWD 180
LAEEIHGMMDKAKNLKRLWVERSNTPDSSYGSSFFTMDLNKTEEVILKLESLHQQPHIWD
Sbjct: 121 LAEEIHGMMDKAKNLKRLWVERSNTPDSSYGSSFFTMDLNKTEEVILKLESLHQQPHIWD 180
Query: 181 FLLLLPRLHTSHDHVEDGMDVAVNLLQTILNSLISLEDLDWLPLNQTFSQVSELVLNVTI 240
FLLLLPRLHTSHDHVEDGMDVAVNLLQTILNSLISLEDLDWLPLNQTFSQVSELVLNVTI
Sbjct: 181 FLLLLPRLHTSHDHVEDGMDVAVNLLQTILNSLISLEDLDWLPLNQTFSQVSELVLNVTI 240
Query: 241 STLTFLQQHGVAVTEPVYHLSMQNIVWDPQKVQYDLKSQFGFDDLHTEQILNSSAELKEI 300
STLTFLQQHGVAVTEPVYHLSMQNIVWDPQKVQYDLKSQFGFDDLHTEQILNSSAELKEI
Sbjct: 241 STLTFLQQHGVAVTEPVYHLSMQNIVWDPQKVQYDLKSQFGFDDLHTEQILNSSAELKEI 300
Query: 301 PTDTSLEKMVCSVLSSTSEDEAEKWGHVGGCHPKWSEAKNYLVHAVSWLRVYQQVFVQWQ 360
PTDTSLEKMVCSVLSSTSEDEAEKWGHVGGCHPKWSEAKNYLVHAVSWLRVYQQVFVQWQ
Sbjct: 301 PTDTSLEKMVCSVLSSTSEDEAEKWGHVGGCHPKWSEAKNYLVHAVSWLRVYQQVFVQWQ 360
Query: 361 QGSLLQKTLTGMGHSLEALRNQFEEESKPWKVVEALHTALLLLNDSLSADGPKDNHTFPK 420
QGSLLQKTLTGMGHSLEALRNQFEEESKPWKVVEALHTALLLLNDSLSADGPKDNHTFPK
Sbjct: 361 QGSLLQKTLTGMGHSLEALRNQFEEESKPWKVVEALHTALLLLNDSLSADGPKDNHTFPK 420
Query: 421 ILQHLWKLQSLLQNLPQWPALKRFLQLDGALRNAIAQNLHFVQEVLICLETSANDFKWFE 480
ILQHLWKLQSLLQNLPQWPALKRFLQLDGALRNAIAQNLHFVQEVLICLETSANDFKWFE
Sbjct: 421 ILQHLWKLQSLLQNLPQWPALKRFLQLDGALRNAIAQNLHFVQEVLICLETSANDFKWFE 480
Query: 481 LNQLKLEKDVFFWELKQMLAKNAVCPNGRFSEKEVFLPPGNSSIWGGLQGLLCYCNSSET 540
LNQLKLEKDVFFWELKQMLAKNAVCPNGRFSEKEVFLPPGNSSIWGGLQGLLCYCNSSET
Sbjct: 481 LNQLKLEKDVFFWELKQMLAKNAVCPNGRFSEKEVFLPPGNSSIWGGLQGLLCYCNSSET 540
Query: 541 SVLNKLLGSVEDADRILQEVITWHKNMSVLIPEEYLDWQELEMQLSEASLSCTRLFLLLG 600
SVLNKLLGSVEDADRILQEVITWHKNMSVLIPEEYLDWQELEMQLSEASLSCTRLFLLLG
Sbjct: 541 SVLNKLLGSVEDADRILQEVITWHKNMSVLIPEEYLDWQELEMQLSEASLSCTRLFLLLG 600
Query: 601 ADPSPENDVFSSDCKHQLVSTVIFHTLEKTQFFLEQAYYWKAFKKFIRKTCEVAQYVNMQ 660
ADPSPENDVFSSDCKHQLVSTVIFHTLEKTQFFLEQAYYWKAFKKFIRKTCEVAQYVNMQ
Sbjct: 601 ADPSPENDVFSSDCKHQLVSTVIFHTLEKTQFFLEQAYYWKAFKKFIRKTCEVAQYVNMQ 660
Query: 661 ESFQNRLLAFPEESPCFEENMDWKMISDNYFQFLNNLLKSPTASISRALNFTKHLLMMEK 720
ESFQNRLLAFPEESPCFEENMDWKMISDNYFQFLNNLLKSPTASISRALNFTKHLLMMEK
Sbjct: 661 ESFQNRLLAFPEESPCFEENMDWKMISDNYFQFLNNLLKSPTASISRALNFTKHLLMMEK 720
Query: 721 KLHTLEDEQMNFLLSFVEFFEKLLLPNLFDSSIVPSFHSLPSLTEDILNISSLWTNHLKS 780
KLHTLEDEQMNFLLSFVEFFEKLLLPNLFDSSIVPSFHSLPSLTEDILNISSLWTNHLKS
Sbjct: 721 KLHTLEDEQMNFLLSFVEFFEKLLLPNLFDSSIVPSFHSLPSLTEDILNISSLWTNHLKS 780
Query: 781 LKRDPSATDAQKLLEFGNEVIWKMQTLGSHWIRKEPKNLLRFIELILFEINPKLLELWAY 840
LKRDPSATDAQKLLEFGNEVIWKMQTLGSHWIRKEPKNLLRFIELILFEINPKLLELWAY
Sbjct: 781 LKRDPSATDAQKLLEFGNEVIWKMQTLGSHWIRKEPKNLLRFIELILFEINPKLLELWAY 840
Query: 841 GISKGKRAKLENFFTLLNFSVPENEILSTSFNFSQLFHSDWPKSPAMNIDFVRLSEAIIT 900
GISKGKRAKLENFFTLLNFSVPENEILSTSFNFSQLFHSDWPKSPAMNIDFVRLSEAIIT
Sbjct: 841 GISKGKRAKLENFFTLLNFSVPENEILSTSFNFSQLFHSDWPKSPAMNIDFVRLSEAIIT 900
Query: 901 SLHEFGFLEQEQISEALNTVYAIRNASDLFSALSEPQKQEVDKILTHIHLNVFQDKDSAL 960
SLHEFGFLEQEQISEALNTVYAIRNASDLFSALSEPQKQEVDKILTHIHLNVFQDKDSAL
Sbjct: 901 SLHEFGFLEQEQISEALNTVYAIRNASDLFSALSEPQKQEVDKILTHIHLNVFQDKDSAL 960
Query: 961 LLQIYSSFYRYIYELLNIQSRGSSLTFLTQISKHILDIIKQFNFQNISKAFAFLFKTAEV 1020
LLQIYSSFYRYIYELLNIQSRGSSLTFLTQISKHILDIIKQFNFQNISKAFAFLFKTAEV
Sbjct: 961 LLQIYSSFYRYIYELLNIQSRGSSLTFLTQISKHILDIIKQFNFQNISKAFAFLFKTAEV 1020
Query: 1021 LGGISNVSYCQQLLSIFNFLELQAQSFMSTEGQELEVIHTTLTGLKQLLIIDEDFRISLF 1080
LGGISNVSYCQQLLSIFNFLELQAQSFMSTEGQELEVIHTTLTGLKQLLIIDEDFRISLF
Sbjct: 1021 LGGISNVSYCQQLLSIFNFLELQAQSFMSTEGQELEVIHTTLTGLKQLLIIDEDFRISLF 1080
Query: 1081 QYMSQFFNSSVEDLLDNKCLISDNKHISSVNYSTSEESSFVFPLAQIFSNLSANVSVFNK 1140
QYMSQFFNSSVEDLLDNKCLISDNKHISSVNYSTSEESSFVFPLAQIFSNLSANVSVFNK
Sbjct: 1081 QYMSQFFNSSVEDLLDNKCLISDNKHISSVNYSTSEESSFVFPLAQIFSNLSANVSVFNK 1140
Query: 1141 FMSIHCTVSWLQMWTEIWETISQLFKFDMNVFTSLHHGFTQLLDELEDDVKVSKSCQGIL 1200
FMSIHCTVSWLQMWTEIWETISQLFKFDMNVFTSLHHGFTQLLDELEDDVKVSKSCQGIL
Sbjct: 1141 FMSIHCTVSWLQMWTEIWETISQLFKFDMNVFTSLHHGFTQLLDELEDDVKVSKSCQGIL 1200
Query: 1201 PTHNVARLILNLFKNVTQANDFHNWEDFLDLRDFLVALGNALVSVKKLNLEQVEKSLFTM 1260
PTHNVARLILNLFKNVTQANDFHNWEDFLDLRDFLVALGNALVSVKKLNLEQVEKSLFTM
Sbjct: 1201 PTHNVARLILNLFKNVTQANDFHNWEDFLDLRDFLVALGNALVSVKKLNLEQVEKSLFTM 1260
Query: 1261 EAALHQLKTFPFNESTSREFLNSLLEVFIEFSSTSEYIVRNLDSINDFLSNNLTNYGEKF 1320
EAALHQLKTFPFNESTSREFLNSLLEVFIEFSSTSEYIVRNLDSINDFLSNNLTNYGEKF
Sbjct: 1261 EAALHQLKTFPFNESTSREFLNSLLEVFIEFSSTSEYIVRNLDSINDFLSNNLTNYGEKF 1320
Query: 1321 ENIITELREAIVFLRNVSHDRDLFSCADIFQNVTECILEDGFLYVNTSQRMLRILDTLNS 1380
ENIITELREAIVFLRNVSHDRDLFSCADIFQNVTECILEDGFLYVNTSQRMLRILDTLNS
Sbjct: 1321 ENIITELREAIVFLRNVSHDRDLFSCADIFQNVTECILEDGFLYVNTSQRMLRILDTLNS 1380
Query: 1381 TFSSENTISSLKGCIVWLDVINHLYLLSNSSFSQGHLQNILGNFRDIENKMNSILKIVTW 1440
TFSSENTISSLKGCIVWLDVINHLYLLSNSSFSQGHLQNILGNFRDIENKMNSILKIVTW
Sbjct: 1381 TFSSENTISSLKGCIVWLDVINHLYLLSNSSFSQGHLQNILGNFRDIENKMNSILKIVTW 1440
Query: 1441 VLNIKKPLCSSNGSHINCVNIYLKDVTDFLNIVLTTVFEKEKKPKFEILLALLNDSTKQV 1500
VLNIKKPLCSSNGSHINCVNIYLKDVTDFLNIVLTTVFEKEKKPKFEILLALLNDSTKQV
Sbjct: 1441 VLNIKKPLCSSNGSHINCVNIYLKDVTDFLNIVLTTVFEKEKKPKFEILLALLNDSTKQV 1500
Query: 1501 RMSINNLTTDFDFASQSNWRYFTELILRPIEMSDEIPNQFQNIWLHLITLGKEFQKLVKG 1560
RMSINNLTTDFDFASQSNWRYFTELILRPIEMSDEIPNQFQNIWLHLITLGKEFQKLVKG
Sbjct: 1501 RMSINNLTTDFDFASQSNWRYFTELILRPIEMSDEIPNQFQNIWLHLITLGKEFQKLVKG 1560
Query: 1561 IYFNILENNSSSKTENLLNIFATSPKEKDVNSVGNSIYHLASYLAFSLSHDLQNSPKIII 1620
IYFNILENNSSSKTENLLNIFATSPKEKDVNSVGNSIYHLASYLAFSLSHDLQNSPKIII
Sbjct: 1561 IYFNILENNSSSKTENLLNIFATSPKEKDVNSVGNSIYHLASYLAFSLSHDLQNSPKIII 1620
Query: 1621 SPEIMKATGLGIQLIRDVFNSLMPVVHHTSPQNAGYMQALKKVTSVMRTLKKADIDLLVD 1680
SPEIMKATGLGIQLIRDVFNSLMPVVHHTSPQNAGYMQALKKVTSVMRTLKKADIDLLVD
Sbjct: 1621 SPEIMKATGLGIQLIRDVFNSLMPVVHHTSPQNAGYMQALKKVTSVMRTLKKADIDLLVD 1680
Query: 1681 QLEQVSVNLMDFFKNISSVGTGNLVVNLLVGLMEKFADSSHSWNVNHLLQLSRLFPKDVV 1740
QLEQVSVNLMDFFKNISSVGTGNLVVNLLVGLMEKFADSSHSWNVNHLLQLSRLFPKDVV
Sbjct: 1681 QLEQVSVNLMDFFKNISSVGTGNLVVNLLVGLMEKFADSSHSWNVNHLLQLSRLFPKDVV 1740
Query: 1741 DAVIDVYYVLPHAVRLLQGVPGKNITEGLKDVYSFTLLHGITISNITKEDFAIVIKILLD 1800
DAVIDVYYVLPHAVRLLQGVPGKNITEGLKDVYSFTLLHGITISNITKEDFAIVIKILLD
Sbjct: 1741 DAVIDVYYVLPHAVRLLQGVPGKNITEGLKDVYSFTLLHGITISNITKEDFAIVIKILLD 1800
Query: 1801 TIELVSDKPDIISEALACFPVVWCWNHTNSGFRQNSKIDPCNVHGLMSSSFYGKVASILD 1860
TIELVSDKPDIISEALACFPVVWCWNHTNSGFRQNSKIDPCNVHGLMSSSFYGKVASILD
Sbjct: 1801 TIELVSDKPDIISEALACFPVVWCWNHTNSGFRQNSKIDPCNVHGLMSSSFYGKVASILD 1860
Query: 1861 HFHLSPQGEDSPCSNESSRMEITRKVVCIIHELVDWNSILLELSEVFHVNISLVKTVQKF 1920
HFHLSPQGEDSPCSNESSRMEITRKVVCIIHELVDWNSILLELSEVFHVNISLVKTVQKF
Sbjct: 1861 HFHLSPQGEDSPCSNESSRMEITRKVVCIIHELVDWNSILLELSEVFHVNISLVKTVQKF 1920
Query: 1921 WHKILPFVPPSINQTRDSISELCPSGSIKQVALQIIEKLKNVNFTKVTSGENILDKLSSL 1980
WHKILPFVPPSINQTRDSISELCPSGSIKQVALQIIEKLKNVNFTKVTSGENILDKLSSL
Sbjct: 1921 WHKILPFVPPSINQTRDSISELCPSGSIKQVALQIIEKLKNVNFTKVTSGENILDKLSSL 1980
Query: 1981 NKILNINEDTETSVQNIISSNLERTVQLISEDWSLEKSTHNLLSLFMMLQNANVTGSSLE 2040
NKILNINEDTETSVQNIISSNLERTVQLISEDWSLEKSTHNLLSLFMMLQNANVTGSSLE
Sbjct: 1981 NKILNINEDTETSVQNIISSNLERTVQLISEDWSLEKSTHNLLSLFMMLQNANVTGSSLE 2040
Query: 2041 ALSSFIEKSETPYNFEELWPKFQQIMKDLTQDFRIRHLLSEMNKGIKSINSMALQKITLQ 2100
ALSSFIEKSETPYNFEELWPKFQQIMKDLTQDFRIRHLLSEMNKGIKSINSMALQKITLQ
Sbjct: 2041 ALSSFIEKSETPYNFEELWPKFQQIMKDLTQDFRIRHLLSEMNKGIKSINSMALQKITLQ 2100
Query: 2101 FAHFLEILDSPSLKTLEIIEDFLLVTKNWLQEYANEDYSRMIETLFIPVTNESSTEDIAL 2160
FAHFLEILDSPSLKTLEIIEDFLLVTKNWLQEYANEDYSRMIETLFIPVTNESSTEDIAL
Sbjct: 2101 FAHFLEILDSPSLKTLEIIEDFLLVTKNWLQEYANEDYSRMIETLFIPVTNESSTEDIAL 2160
Query: 2161 LAKAIATFWGSLKNISRAGNFDVAFLTHLLNQEQLTNFSVVQLLFENILINLINNLAGNS 2220
LAKAIATFWGSLKNISRAGNFDVAFLTHLLNQEQLTNFSVVQLLFENILINLINNLAGNS
Sbjct: 2161 LAKAIATFWGSLKNISRAGNFDVAFLTHLLNQEQLTNFSVVQLLFENILINLINNLAGNS 2220
Query: 2221 QEAAWNLNDTDLQIMNFINLILNHMQSETSRKTVLSLRSIVDFTEQFLKTFFSLFLKEDS 2280
QEAAWNLNDTDLQIMNFINLILNHMQSETSRKTVLSLRSIVDFTEQFLKTFFSLFLKEDS
Sbjct: 2221 QEAAWNLNDTDLQIMNFINLILNHMQSETSRKTVLSLRSIVDFTEQFLKTFFSLFLKEDS 2280
Query: 2281 ENKISLLLKYFHKDVIAEMSFVPKDKILEILKLDQFLTLMIQDRLMNIFSSLKETIYHLM 2340
ENKISLLLKYFHKDVIAEMSFVPKDKILEILKLDQFLTLMIQDRLMNIFSSLKETIYHLM
Sbjct: 2281 ENKISLLLKYFHKDVIAEMSFVPKDKILEILKLDQFLTLMIQDRLMNIFSSLKETIYHLM 2340
Query: 2341 KSSFILDNGEFYFDTHQGLKFMQDLFNALLRETSMKNKTENNIDFFTVVSQLFFHVNKSE 2400
KSSFILDNGEFYFDTHQGLKFMQDLFNALLRETSMKNKTENNIDFFTVVSQLFFHVNKSE
Sbjct: 2341 KSSFILDNGEFYFDTHQGLKFMQDLFNALLRETSMKNKTENNIDFFTVVSQLFFHVNKSE 2400
Query: 2401 DLFKLNQDLGSALHLVRECSTEMARLLDTILHSPNKDFYALYPTLQEVILANLTDLLFFI 2460
DLFKLNQDLGSALHLVRECSTEMARLLDTILHSPNKDFYALYPTLQEVILANLTDLLFFI
Sbjct: 2401 DLFKLNQDLGSALHLVRECSTEMARLLDTILHSPNKDFYALYPTLQEVILANLTDLLFFI 2460
Query: 2461 NNSFPLRNRATLEITKRLVGAISRASEESHVLKPLLEMSGTLVMLLNDSADLRDLATSMD 2520
NNSFPLRNRATLEITKRLVGAISRASEESHVLKPLLEMSGTLVMLLNDSADLRDLATSMD
Sbjct: 2461 NNSFPLRNRATLEITKRLVGAISRASEESHVLKPLLEMSGTLVMLLNDSADLRDLATSMD 2520
Query: 2521 SIVKLLKLVKKVSGKMSTVFKTHFISNTKDSVKFFDTLYSIMQQSVQNLVKEIATLKKID 2580
SIVKLLKLVKKVSGKMSTVFKTHFISNTKDSVKFFDTLYSIMQQSVQNLVKEIATLKKID
Sbjct: 2521 SIVKLLKLVKKVSGKMSTVFKTHFISNTKDSVKFFDTLYSIMQQSVQNLVKEIATLKKID 2580
Query: 2581 HFTFEKINDLLVPFLDLAFEMIGVEPYISSNSDIFSMSPSILSYMNQSKDFSDILEEIAE 2640
HFTFEKINDLLVPFLDLAFEMIGVEPYISSNSDIFSMSPSILSYMNQSKDFSDILEEIAE
Sbjct: 2581 HFTFEKINDLLVPFLDLAFEMIGVEPYISSNSDIFSMSPSILSYMNQSKDFSDILEEIAE 2640
Query: 2641 FLTSVKMNLEDMRSLAVAFNNETQTFSMDSVNLREEILGCLVPINNITNQMDFLYPNPIS 2700
FLTSVKMNLEDMRSLAVAFNNETQTFSMDSVNLREEILGCLVPINNITNQMDFLYPNPIS
Sbjct: 2641 FLTSVKMNLEDMRSLAVAFNNETQTFSMDSVNLREEILGCLVPINNITNQMDFLYPNPIS 2700
Query: 2701 THSGPQDIKWEIIHEVIPFLDKILSQNSTEIGSFLKMVICLTLEALWKNLKKDNWNVSNV 2760
THSGPQDIKWEIIHEVIPFLDKILSQNSTEIGSFLKMVICLTLEALWKNLKKDNWNVSNV
Sbjct: 2701 THSGPQDIKWEIIHEVIPFLDKILSQNSTEIGSFLKMVICLTLEALWKNLKKDNWNVSNV 2760
Query: 2761 LMTFTQHPNNLLKTIETVLEASSGIKSDYEGDLNKSLYFDTPLSQNITHHQLEKAIHNVL 2820
LMTFTQHPNNLLKTIETVLEASSGIKSDYEGDLNKSLYFDTPLSQNITHHQLEKAIHNVL
Sbjct: 2761 LMTFTQHPNNLLKTIETVLEASSGIKSDYEGDLNKSLYFDTPLSQNITHHQLEKAIHNVL 2820
Query: 2821 SRIALWRKGLLFNNSEWITSTRTLFQPLFEIFIKATTGKNVTSEKEERTKKEMIDFPYSF 2880
SRIALWRKGLLFNNSEWITSTRTLFQPLFEIFIKATTGKNVTSEKEERTKKEMIDFPYSF
Sbjct: 2821 SRIALWRKGLLFNNSEWITSTRTLFQPLFEIFIKATTGKNVTSEKEERTKKEMIDFPYSF 2880
Query: 2881 KPFFCLEKYLGGLFVLTKYWQQIPLTDQSVVEICEVFQQTVKPSEAMEMLQKVKMMVVRV 2940
KPFFCLEKYLGGLFVLTKYWQQIPLTDQSVVEICEVFQQTVKPSEAMEMLQKVKMMVVRV
Sbjct: 2881 KPFFCLEKYLGGLFVLTKYWQQIPLTDQSVVEICEVFQQTVKPSEAMEMLQKVKMMVVRV 2940
Query: 2941 LTIVAENPSWTKDILCATLSCKQNGIRHLILSAIQGVTLAQDHFQEIEKIWSSPNQLNCE 3000
LTIVAENPSWTKDILCATLSCKQNGIRHLILSAIQGVTLAQDHFQEIEKIWSSPNQLNCE
Sbjct: 2941 LTIVAENPSWTKDILCATLSCKQNGIRHLILSAIQGVTLAQDHFQEIEKIWSSPNQLNCE 3000
Query: 3001 SLSKNLSSTLESFKSSLENATGQDCTSQPRLETVQQHLYMLAKSLEETWSSGNPIMTFLS 3060
SLSKNLSSTLESFKSSLENATGQDCTSQPRLETVQQHLYMLAKSLEETWSSGNPIMTFLS
Sbjct: 3001 SLSKNLSSTLESFKSSLENATGQDCTSQPRLETVQQHLYMLAKSLEETWSSGNPIMTFLS 3060
Query: 3061 NFTVTEDVKIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGK 3120
NFTVTEDVKIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGK
Sbjct: 3061 NFTVTEDVKIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGK 3120
Query: 3121 CDQEILHLLLTFPKGEKSWIAAEELCSLPGSKVYSLIVLLSRNLDVRAFIYKTLMPSEAN 3180
CDQEILHLLLTFPKGEKSWIAAEELCSLPGSKVYSLIVLLSRNLDVRAFIYKTLMPSEAN
Sbjct: 3121 CDQEILHLLLTFPKGEKSWIAAEELCSLPGSKVYSLIVLLSRNLDVRAFIYKTLMPSEAN 3180
Query: 3181 GLLNSLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFG 3240
GLLNSLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFG
Sbjct: 3181 GLLNSLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFG 3240
Query: 3241 SFQFVMKMVCKDQASFLSDSNMFINLPRVKELLEDDKEKFNIPEDSTPFCLKLYQEILQL 3300
SFQFVMKMVCKDQASFLSDSNMFINLPRVKELLEDDKEKFNIPEDSTPFCLKLYQEILQL
Sbjct: 3241 SFQFVMKMVCKDQASFLSDSNMFINLPRVKELLEDDKEKFNIPEDSTPFCLKLYQEILQL 3300
Query: 3301 PNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSSLFQR 3360
PNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSSLFQR
Sbjct: 3301 PNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSSLFQR 3360
Query: 3361 SGSGQMFNQLQEALRNKFVRNFVENQLHIDVDKLTEKLQTYGGLLDEMFNHAGAGRFRFL 3420
SGSGQMFNQLQEALRNKFVRNFVENQLHIDVDKLTEKLQTYGGLLDEMFNHAGAGRFRFL
Sbjct: 3361 SGSGQMFNQLQEALRNKFVRNFVENQLHIDVDKLTEKLQTYGGLLDEMFNHAGAGRFRFL 3420
Query: 3421 GSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIFSNSLFDKNFRSESVKL 3480
GSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIFSNSLFDKNFRSESVKL
Sbjct: 3421 GSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIFSNSLFDKNFRSESVKL 3480
Query: 3481 PPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPLQDMIERAIILVQT 3540
PPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPLQDMIERAIILVQT
Sbjct: 3481 PPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPLQDMIERAIILVQT 3540
Query: 3541 GQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIE 3600
GQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIE
Sbjct: 3541 GQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIE 3600
Query: 3601 EYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGMS 3660
EYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGMS
Sbjct: 3601 EYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGMS 3660
Query: 3661 VVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFG 3720
VVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFG
Sbjct: 3661 VVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFG 3720
Query: 3721 QGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGT 3780
QGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGT
Sbjct: 3721 QGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGT 3780
Query: 3781 FGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGSAP 3840
FGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGSAP
Sbjct: 3781 FGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGSAP 3840
Query: 3841 GVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTII 3900
GVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTII
Sbjct: 3841 GVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTII 3900
Query: 3901 INGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTL 3960
INGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTL
Sbjct: 3901 INGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTL 3960
Query: 3961 QDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLK 4020
QDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLK
Sbjct: 3961 QDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLK 4020
Query: 4021 YREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVL 4080
YREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVL
Sbjct: 4021 YREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVL 4080
Query: 4081 EAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLH 4140
EAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLH
Sbjct: 4081 EAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLH 4140
Query: 4141 LTGYGISDTTLEEVFLMLLQDSNKKSHIALGTESELQNHRPTGHLSGYCGSLARPATVQG 4200
LTGYGISDTTLEEVFLMLLQDSNKKSHIALGTESELQNHRPTGHLSGYCGSLARPATVQG
Sbjct: 4141 LTGYGISDTTLEEVFLMLLQDSNKKSHIALGTESELQNHRPTGHLSGYCGSLARPATVQG 4200
Query: 4201 VQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTP 4260
VQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTP
Sbjct: 4201 VQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTP 4260
Query: 4261 GHYQRAETYFFSSGGDNLDLTRVLLRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQD 4320
GHYQRAETYFFSSGGDNLDLTRVLLRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQD
Sbjct: 4261 GHYQRAETYFFSSGGDNLDLTRVLLRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQD 4320
Query: 4321 SCGCLKCPNRSASAPYLTNHLGHTLLNLSGFNMEEYLLAPSEKPRLGGWSFGLKIPSEAG 4380
SCGCLKCPNRSASAPYLTNHLGHTLLNLSGFNMEEYLLAPSEKPRLGGWSFGLKIPSEAG
Sbjct: 4321 SCGCLKCPNRSASAPYLTNHLGHTLLNLSGFNMEEYLLAPSEKPRLGGWSFGLKIPSEAG 4380
Query: 4381 GANGNISKPPTLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYG 4440
GANGNISKPPTLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYG
Sbjct: 4381 GANGNISKPPTLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYG 4440
Query: 4441 GALLNKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYW 4500
GALLNKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYW
Sbjct: 4441 GALLNKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYW 4500
Query: 4501 FTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRI 4560
FTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRI
Sbjct: 4501 FTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRI 4560
Query: 4561 FSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCL 4620
FSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCL
Sbjct: 4561 FSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCL 4620
Query: 4621 GQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLL 4680
GQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLL
Sbjct: 4621 GQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLL 4680
Query: 4681 RWPRGHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQDI 4740
RWPRGHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQDI
Sbjct: 4681 RWPRGHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQDI 4740
Query: 4741 SLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLI 4800
SLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLI
Sbjct: 4741 SLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLI 4800
Query: 4801 GYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGG 4860
GYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGG
Sbjct: 4801 GYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGG 4860
Query: 4861 TKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECE 4920
TKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECE
Sbjct: 4861 TKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECE 4920
Query: 4921 ALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQF 4980
ALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQF
Sbjct: 4921 ALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQF 4980
Query: 4981 KGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTL 5040
KGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTL
Sbjct: 4981 KGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTL 5040
Query: 5041 QSTLDPSTDSHHTHHLPI 5058
QSTLDPSTDSHHTHHLPI
Sbjct: 5041 QSTLDPSTDSHHTHHLPI 5058
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 1454 bits (3764), Expect = 0.0
Identities = 843/2053 (41%), Positives = 1212/2053 (59%), Gaps = 92/2053 (4%)
Query: 3069 KIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGKCDQEILHL 3128
++ ++ KN+ +L E+LR + +SN TI +L I ++ + L CD I
Sbjct: 236 QLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAIPIPDNRAEIISQVFWLHS-CDTNI--- 291
Query: 3129 LLTFPKGEKSWIAAEELCSLPGSK----VYSLIVLLSRNLDVRAFIYKTLMPSEANGLLN 3184
T PK E A +E C+L S+ Y + + L L++ F YK P + +
Sbjct: 292 --TTPKLED---AMKEFCNLSLSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQKPVE 346
Query: 3185 SLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFGSFQF 3244
++++ L +L + L + + + K L ++ Q ++ GSF
Sbjct: 347 KMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQGSFST 406
Query: 3245 VMKMVCKDQASFLSDSNMFINLPR-----VKELL------EDDKEKFNIPEDSTPFCLKL 3293
+ + +C + + M + R K+ L E K+ IP +STPFC L
Sbjct: 407 ISQALCSQGITTEYLTAMLPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPFCFSL 466
Query: 3294 YQEILQLPNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLE 3353
Y++I+ +P G ++W FLKP+L G+ILY P P +++K+N T + +L+ S+ ++
Sbjct: 467 YKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMD 526
Query: 3354 MSSLFQRSGS--GQMFNQLQEALRNKFVRNFVENQLHIDVDKLTEKLQTYGGLLDEMFNH 3411
S LF S Q LQ LRN FV+ FV+ + +D +L +++ L ++ N+
Sbjct: 527 KSPLFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLKLENN 586
Query: 3412 AGA-GRFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIF---SNS 3467
+ L S+ VN+SSCV +R QA +++D +E +A L + N S+IF SN
Sbjct: 587 IDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNR 646
Query: 3468 LFDKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPL 3527
+ + + S +V LPP + YTIR ++ + T ++ W P N P+ Y F L
Sbjct: 647 SWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYL 706
Query: 3528 QDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASM 3587
QD IERAII +QTG+ + E A Q QA PYPC D FL +V + P+++M+ W+V +A+
Sbjct: 707 QDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAF 766
Query: 3588 VRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNT 3647
V+KLVYE+++++ EYM+MMGV+ HF AW +E++ L ++ L I+LK I +N
Sbjct: 767 VKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNG 826
Query: 3648 FIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVN 3707
FI+FL+ D+ SV+ +SYL+S FF+ N AAL SL+Y+I+F P+IVL+ + N+LS+V
Sbjct: 827 FILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVL 886
Query: 3708 QTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMT-FGWVCWMILFDSSLY 3766
+ F+ LLS TAF +I E Q G+QW NMY + Q T FGW+C +IL DS +Y
Sbjct: 887 KVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIY 946
Query: 3767 FLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGS 3826
FL WY+ N+ PGT+G+ PWYFP SYWK E + S+ L F N N
Sbjct: 947 FLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPE-KSNGLMFTNIMMQNTNP 1005
Query: 3827 SLQ-------NREGELEGSAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGA 3879
S N E E + GV L VTK Y G K V +L+L FY IT+LLG NGA
Sbjct: 1006 SASPEYMFSSNIEPEPKDLTVGVALHGVTKIY-GSKVAVDNLNLNFYEGHITSLLGPNGA 1064
Query: 3880 GKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLF 3939
GKTT ISMLTGL ++GTI + GK+++TDL VR +GVC Q D+L LT +EHLLL+
Sbjct: 1065 GKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLY 1124
Query: 3940 ASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVL 3999
SIK P WTKK+LH++V +TL+D L H+HK+ LSGG+KRKLS+ IA +G SR V+L
Sbjct: 1125 GSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVIL 1184
Query: 4000 DEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPF 4059
DEP++GVDPCSR S+WD++ K + RTII +THHLDEAE LSDR+A L+ G LRCCG PF
Sbjct: 1185 DEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPF 1244
Query: 4060 CLKEAYGQGLRLTLTRQPSV-LEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPK 4118
LKEA+G G LTLT++ S L A+ + D VT++I+ ++P+A+LK+ G EL Y +P
Sbjct: 1245 YLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPP 1304
Query: 4119 DTDKA--CLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSNKKSHIALG--TES 4174
+ K L +ALD + L++ YGISDTT+EEVFL L ++S K S ++L T+
Sbjct: 1305 FSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQK 1364
Query: 4175 ELQNHRPTG-----HLSGYCGS--------LARPATVQGVQLLRAQVAAILARRLRRTLR 4221
++ N G LS + L R + G LL ++ AIL +R T R
Sbjct: 1365 KIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRR 1424
Query: 4222 AGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAE-TYFFSSGGDNLDL 4280
K +A ++LP++FV AMGL +R + YP ++++P Y +E T F+++ + +
Sbjct: 1425 NWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEA 1484
Query: 4281 TRVLLRKFRDQDLPC---ADLNPRQKNS-SCWRTDPFSHPEFQDSCGCLK----CPNRSA 4332
+ F D C +DL K+S W T F C C + CP +
Sbjct: 1485 LVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNF-GVCSCSENVQECPKFNY 1543
Query: 4333 SAPYLTNHLGHTLLNLSGFNMEEYLLAPSEK---PRLGGWSFGLKIPSEAGGANGNISKP 4389
S P+ + + NL+G +E YL++ + + R GGWSFGL + + +
Sbjct: 1544 SPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPAN 1603
Query: 4390 PTLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKI 4449
TLAKVWY+ +G+HSLP+YLN LNN +L ++ D ++GI +YSHPY G +
Sbjct: 1604 RTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSK-YDAARHGIIMYSHPYPGVQDQEQAT 1662
Query: 4450 LESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDML 4509
+ S+ VAL I++G+S+ +AS + VVR+ AK+LQHISG+G YW TNF+YDM+
Sbjct: 1663 ISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMV 1722
Query: 4510 FYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFI 4569
FYLV V + +I F+L AF NL A +LLL LFGYAT WMYL++ +F + +AFI
Sbjct: 1723 FYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFI 1782
Query: 4570 SYVSLNFIFGLCTMLITIMPRLLAIISKAK----NLQNIYDVLKWVFTIFPQFCLGQGLV 4625
+YV +N FG+ ++ + ++ +SK K L+ I + LK +F IFPQFC G GL+
Sbjct: 1783 TYVCVNLFFGINSI---VSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLI 1839
Query: 4626 ELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPR- 4684
EL Q D +G++ FEMN LG +FV L SQGT+ LR+L++ L++ R
Sbjct: 1840 ELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL 1899
Query: 4685 -----GHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQD 4739
S ++ T+ +D DV E RV G D++ LY L+K Y+ + IIAV +
Sbjct: 1900 FFRKFNSSHVRETI--DEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNN 1957
Query: 4740 ISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVL 4799
IS+GIP GECFGLLGVNGAGK+T FKML G++ +SG+ +IR G + S + L
Sbjct: 1958 ISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSS---L 2014
Query: 4800 IGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSG 4859
+GYCPQ+DALD+L+T EHLY+Y + GIP + I E L+RRLHL D+ + S
Sbjct: 2015 VGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSY 2074
Query: 4860 GTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEEC 4919
GTKRKLSTALAL+GKP ILLLDEPSSGMDP SKR+LW+ I +EV+ C+ +LTSHSMEEC
Sbjct: 2075 GTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEEC 2134
Query: 4920 EALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQ 4979
EALCTRLAIMVNG F+C+GS QHIK+RFG G+TVKV L T++ ++L+FP
Sbjct: 2135 EALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTY 2194
Query: 4980 FKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQ-- 5037
K QHL++LEYHVP G +A++F ++E NKT LNI ++ ++QTTLE+VFINFA +Q+
Sbjct: 2195 LKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSY 2254
Query: 5038 QTLQSTLDPSTDS 5050
+T ++ ST S
Sbjct: 2255 ETADTSSQGSTIS 2267
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 1454 bits (3764), Expect = 0.0
Identities = 843/2053 (41%), Positives = 1212/2053 (59%), Gaps = 92/2053 (4%)
Query: 3069 KIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGKCDQEILHL 3128
++ ++ KN+ +L E+LR + +SN TI +L I ++ + L CD I
Sbjct: 554 QLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAIPIPDNRAEIISQVFWLHS-CDTNI--- 609
Query: 3129 LLTFPKGEKSWIAAEELCSLPGSK----VYSLIVLLSRNLDVRAFIYKTLMPSEANGLLN 3184
T PK E A +E C+L S+ Y + + L L++ F YK P + +
Sbjct: 610 --TTPKLED---AMKEFCNLSLSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQKPVE 664
Query: 3185 SLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFGSFQF 3244
++++ L +L + L + + + K L ++ Q ++ GSF
Sbjct: 665 KMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQGSFST 724
Query: 3245 VMKMVCKDQASFLSDSNMFINLPR-----VKELL------EDDKEKFNIPEDSTPFCLKL 3293
+ + +C + + M + R K+ L E K+ IP +STPFC L
Sbjct: 725 ISQALCSQGITTEYLTAMLPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPFCFSL 784
Query: 3294 YQEILQLPNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLE 3353
Y++I+ +P G ++W FLKP+L G+ILY P P +++K+N T + +L+ S+ ++
Sbjct: 785 YKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMD 844
Query: 3354 MSSLFQRSGS--GQMFNQLQEALRNKFVRNFVENQLHIDVDKLTEKLQTYGGLLDEMFNH 3411
S LF S Q LQ LRN FV+ FV+ + +D +L +++ L ++ N+
Sbjct: 845 KSPLFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLKLENN 904
Query: 3412 AGA-GRFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIF---SNS 3467
+ L S+ VN+SSCV +R QA +++D +E +A L + N S+IF SN
Sbjct: 905 IDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNR 964
Query: 3468 LFDKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPL 3527
+ + + S +V LPP + YTIR ++ + T ++ W P N P+ Y F L
Sbjct: 965 SWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYL 1024
Query: 3528 QDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASM 3587
QD IERAII +QTG+ + E A Q QA PYPC D FL +V + P+++M+ W+V +A+
Sbjct: 1025 QDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAF 1084
Query: 3588 VRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNT 3647
V+KLVYE+++++ EYM+MMGV+ HF AW +E++ L ++ L I+LK I +N
Sbjct: 1085 VKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNG 1144
Query: 3648 FIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVN 3707
FI+FL+ D+ SV+ +SYL+S FF+ N AAL SL+Y+I+F P+IVL+ + N+LS+V
Sbjct: 1145 FILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVL 1204
Query: 3708 QTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMT-FGWVCWMILFDSSLY 3766
+ F+ LLS TAF +I E Q G+QW NMY + Q T FGW+C +IL DS +Y
Sbjct: 1205 KVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIY 1264
Query: 3767 FLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGS 3826
FL WY+ N+ PGT+G+ PWYFP SYWK E + S+ L F N N
Sbjct: 1265 FLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPE-KSNGLMFTNIMMQNTNP 1323
Query: 3827 SLQ-------NREGELEGSAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGA 3879
S N E E + GV L VTK Y G K V +L+L FY IT+LLG NGA
Sbjct: 1324 SASPEYMFSSNIEPEPKDLTVGVALHGVTKIY-GSKVAVDNLNLNFYEGHITSLLGPNGA 1382
Query: 3880 GKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLF 3939
GKTT ISMLTGL ++GTI + GK+++TDL VR +GVC Q D+L LT +EHLLL+
Sbjct: 1383 GKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLY 1442
Query: 3940 ASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVL 3999
SIK P WTKK+LH++V +TL+D L H+HK+ LSGG+KRKLS+ IA +G SR V+L
Sbjct: 1443 GSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVIL 1502
Query: 4000 DEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPF 4059
DEP++GVDPCSR S+WD++ K + RTII +THHLDEAE LSDR+A L+ G LRCCG PF
Sbjct: 1503 DEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPF 1562
Query: 4060 CLKEAYGQGLRLTLTRQPSV-LEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPK 4118
LKEA+G G LTLT++ S L A+ + D VT++I+ ++P+A+LK+ G EL Y +P
Sbjct: 1563 YLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPP 1622
Query: 4119 DTDKA--CLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSNKKSHIALG--TES 4174
+ K L +ALD + L++ YGISDTT+EEVFL L ++S K S ++L T+
Sbjct: 1623 FSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQK 1682
Query: 4175 ELQNHRPTG-----HLSGYCGS--------LARPATVQGVQLLRAQVAAILARRLRRTLR 4221
++ N G LS + L R + G LL ++ AIL +R T R
Sbjct: 1683 KIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRR 1742
Query: 4222 AGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAE-TYFFSSGGDNLDL 4280
K +A ++LP++FV AMGL +R + YP ++++P Y +E T F+++ + +
Sbjct: 1743 NWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEA 1802
Query: 4281 TRVLLRKFRDQDLPC---ADLNPRQKNS-SCWRTDPFSHPEFQDSCGCLK----CPNRSA 4332
+ F D C +DL K+S W T F C C + CP +
Sbjct: 1803 LVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNF-GVCSCSENVQECPKFNY 1861
Query: 4333 SAPYLTNHLGHTLLNLSGFNMEEYLLAPSEK---PRLGGWSFGLKIPSEAGGANGNISKP 4389
S P+ + + NL+G +E YL++ + + R GGWSFGL + + +
Sbjct: 1862 SPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPAN 1921
Query: 4390 PTLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKI 4449
TLAKVWY+ +G+HSLP+YLN LNN +L ++ D ++GI +YSHPY G +
Sbjct: 1922 RTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSK-YDAARHGIIMYSHPYPGVQDQEQAT 1980
Query: 4450 LESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDML 4509
+ S+ VAL I++G+S+ +AS + VVR+ AK+LQHISG+G YW TNF+YDM+
Sbjct: 1981 ISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMV 2040
Query: 4510 FYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFI 4569
FYLV V + +I F+L AF NL A +LLL LFGYAT WMYL++ +F + +AFI
Sbjct: 2041 FYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFI 2100
Query: 4570 SYVSLNFIFGLCTMLITIMPRLLAIISKAK----NLQNIYDVLKWVFTIFPQFCLGQGLV 4625
+YV +N FG+ ++ + ++ +SK K L+ I + LK +F IFPQFC G GL+
Sbjct: 2101 TYVCVNLFFGINSI---VSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLI 2157
Query: 4626 ELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPR- 4684
EL Q D +G++ FEMN LG +FV L SQGT+ LR+L++ L++ R
Sbjct: 2158 ELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL 2217
Query: 4685 -----GHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQD 4739
S ++ T+ +D DV E RV G D++ LY L+K Y+ + IIAV +
Sbjct: 2218 FFRKFNSSHVRETI--DEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNN 2275
Query: 4740 ISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVL 4799
IS+GIP GECFGLLGVNGAGK+T FKML G++ +SG+ +IR G + S + L
Sbjct: 2276 ISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSS---L 2332
Query: 4800 IGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSG 4859
+GYCPQ+DALD+L+T EHLY+Y + GIP + I E L+RRLHL D+ + S
Sbjct: 2333 VGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSY 2392
Query: 4860 GTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEEC 4919
GTKRKLSTALAL+GKP ILLLDEPSSGMDP SKR+LW+ I +EV+ C+ +LTSHSMEEC
Sbjct: 2393 GTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEEC 2452
Query: 4920 EALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQ 4979
EALCTRLAIMVNG F+C+GS QHIK+RFG G+TVKV L T++ ++L+FP
Sbjct: 2453 EALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTY 2512
Query: 4980 FKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQ-- 5037
K QHL++LEYHVP G +A++F ++E NKT LNI ++ ++QTTLE+VFINFA +Q+
Sbjct: 2513 LKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSY 2572
Query: 5038 QTLQSTLDPSTDS 5050
+T ++ ST S
Sbjct: 2573 ETADTSSQGSTIS 2585
Score = 88.6 bits (218), Expect = 1e-16
Identities = 38/81 (46%), Positives = 53/81 (65%)
Query: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCG 66
Q + L+WKNWL R P+ L WP I+F+IL + R + PP + CYL PR+LPS G
Sbjct: 7 QLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTG 66
Query: 67 VIPFVQSLLCNTGSRCRNFSY 87
PF+Q+LLC+T S+C++ Y
Sbjct: 67 FFPFLQTLLCDTDSKCKDTPY 87
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 1073 bits (2775), Expect = 0.0
Identities = 715/2157 (33%), Positives = 1097/2157 (50%), Gaps = 256/2157 (11%)
Query: 3065 TEDVKIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGKCDQE 3124
+ ++K++D + + + L ++ + T+ +L A++ KV + L+ C+
Sbjct: 139 SSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGS 198
Query: 3125 ILHLLLTFPKGEKSWIAAEELCSLPGSKVYSLIVLLSRNLDVRAFIYKTL---MPSEANG 3181
++ E S ELC LP K+ + +L N+D+ I +TL P +
Sbjct: 199 KSEEMIQLGDQEVS-----ELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKE 253
Query: 3182 LLNSLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQ---NVQARSSA 3238
L + ++ SL L AQ +F ++ D +Q NV + SS+
Sbjct: 254 LAEATKTLLHSLGTL---AQELF-------------SMRSWSDMRQEVMFLTNVNSSSSS 297
Query: 3239 FGSFQFVMKMVC--KDQASFLSDSNMFINLPRVKELL-----EDDKEKFNIPEDSTPFCL 3291
+Q V ++VC + S + K L E+D E F +TP+C
Sbjct: 298 TQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETF-YDNSTTPYCN 356
Query: 3292 KLYQEILQLPNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETL 3351
L + + P ++W LKP+L GKILYTP+TP +V+ + N TF + L
Sbjct: 357 DLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMW 416
Query: 3352 LEMS-SLFQRSGSGQMFNQLQEALRNKFVRNFVENQLH-ID---------VDKLTEKLQT 3400
E+S ++ + Q + ++ L ++ +F E QL +D + K E +Q+
Sbjct: 417 EELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQS 476
Query: 3401 YGGLL---DEMFNHAGAGRFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNS 3457
G + E FN R + + CV LN+ + + + L K+ ELL +
Sbjct: 477 SNGSVYTWREAFNETNQA-IRTISRFM----ECVNLNKLEPIATEVWLINKSMELLDERK 531
Query: 3458 FLASIIFSNSLFDKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADG 3517
F A I+F+ S++LP HV Y IR ++ RT+ +K+ W P+ P +
Sbjct: 532 FWAGIVFTG------ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFED 585
Query: 3518 FKYNYV-FAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIM 3576
+Y + FA LQD++E+AII V TG E + Q PYPC+ D+FL + PL M
Sbjct: 586 MRYVWGGFAYLQDVVEQAIIRVLTGTEK-KTGVYMQQMPYPCYVDDIFLRVMSRSMPLFM 644
Query: 3577 MLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVL 3636
L W+ SVA +++ +VYE+E +++E MR+MG+ I + +WF+ ++ L +S+ L ++L
Sbjct: 645 TLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVIL 704
Query: 3637 KTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVL 3696
K + +S+ +VF+FL F + ++ +L+S FS+AN AA C ++Y +LPY++
Sbjct: 705 KLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLC 764
Query: 3697 LVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQA-LEQGGMTFGWV 3755
+ + + F + F LLS AFG G + E Q G+QW+N++++ +E+ G
Sbjct: 765 VAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTS 824
Query: 3756 CWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLF 3815
M+LFD+ LY + WY+ + PG +G+ +PWYFP T SYW
Sbjct: 825 VSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYW------------------- 865
Query: 3816 FFNENFDNKGSSLQNR--------EGELEGSAPGVTLVSVTKEY-EGHKAVVQDLSLTFY 3866
F E D K N+ E E GV++ ++ K Y +G K V L+L FY
Sbjct: 866 -FGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFY 924
Query: 3867 RDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDIL 3926
QIT+ LG NGAGKTT +S+LTGL PPTSGT I GK++++++S +R LGVCPQ ++L
Sbjct: 925 EGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVL 984
Query: 3927 LDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHK-QTRALSGGLKRKLS 3985
D LTV EH+ +A +K ++K + ++ Q DV L + K +T LSGG++RKLS
Sbjct: 985 FDMLTVEEHIWFYARLKG--LSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLS 1042
Query: 3986 LGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVA 4045
+ +AF+G S+ V+LDEPT+GVDP SR +W++LLKYR+GRTII +THH+DEA+ L DR+A
Sbjct: 1043 VALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIA 1102
Query: 4046 VLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQP---------------SVLEAHD------ 4084
++ HG+L C G LK G G LTL ++ S L+ D
Sbjct: 1103 IISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSS 1162
Query: 4085 --------------LKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDK-ACLKGLF 4129
D++ +++LI+ ++ +A L + G ELTY +P + K LF
Sbjct: 1163 SDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELF 1222
Query: 4130 QALDENLHQLHLTGYGISDTTLEEVFLMLLQDSNKKSHIALGTESELQNHRPTGHLSGYC 4189
+D+ L L ++ YGIS+TTLEE+FL + ++S + + GT +N R G
Sbjct: 1223 HEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQ--- 1279
Query: 4190 GSLARPAT--------------------------------VQGVQLLRAQVAAILARRLR 4217
S RP T V+G +L + Q A+L +RL
Sbjct: 1280 -SCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLL 1338
Query: 4218 RTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAETYFFSSGGDN 4277
R+ K A ++LP +FV +A+ ++ P +YP L L P Y T+ + ++
Sbjct: 1339 IARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPED 1398
Query: 4278 LDLTRVLLRKFRDQDL--PCADLN-----PRQKNSSCWRTDPFSH---PEFQD------- 4320
+L +D C + N P Q W T P FQ+
Sbjct: 1399 TGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQN 1458
Query: 4321 ---SCGCLK---------CPNRSAS--APYLTNHLGHTLLNLSGFNMEEYL-------LA 4359
+C C CP + P + L +L+G N+ +YL +A
Sbjct: 1459 PSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIA 1518
Query: 4360 PSEKP-------RLGGWSFG------LKIPSEAGGANGNISKPPTLA------------- 4393
S K R GG+S G L E A + K LA
Sbjct: 1519 KSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLG 1578
Query: 4394 ------------KVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYG- 4440
KVW+N KG+H++ S+LN +NN IL +L + YGIT ++HP
Sbjct: 1579 RFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNL 1638
Query: 4441 -GALLNKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMY 4499
L++ ++ + V++C++ S + AS ++++RV AK LQ ISG+ +Y
Sbjct: 1639 TKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIY 1698
Query: 4500 WFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSR 4559
W +NF++DM Y+V L + + + FQ ++ NL ALLL L+G++ P MY S
Sbjct: 1699 WLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASF 1758
Query: 4560 IFSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFC 4619
+F A++ S+N G+ + T + L L NI D+LK VF IFP FC
Sbjct: 1759 VFKIPSTAYVVLTSVNLFIGINGSVATFVLELFT----DNKLNNINDILKSVFLIFPHFC 1814
Query: 4620 LGQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDL 4679
LG+GL+++ NQ D FG + +VSP + +G +A +G V L+ VL+ +
Sbjct: 1815 LGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRF 1874
Query: 4680 LRWPRGHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQD 4739
PR + + + +D DV +E +R+ +G DIL + L+K YRR + AV
Sbjct: 1875 FIRPRPVNAKLSPL-NDEDEDVRRERQRILDGGGQNDILEIKELTKIYRR--KRKPAVDR 1931
Query: 4740 ISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVL 4799
I +GIP GECFGLLGVNGAGKS+TFKML G+ ++T G A + LS+
Sbjct: 1932 ICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNS----ILSNIHEVHQN 1987
Query: 4800 IGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSG 4859
+GYCPQ DA+ ELLTG EH+ ++ LRG+P + + +V IR+L L + +K YSG
Sbjct: 1988 MGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSG 2047
Query: 4860 GTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEEC 4919
G KRKLSTA+AL+G P ++ LDEP++GMDP ++R+LW + V+EG + VLTSHSMEEC
Sbjct: 2048 GNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEEC 2107
Query: 4920 EALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQ 4979
EALCTR+AIMVNG F+CLGS QH+KNRFGDGYT+ V + V D L FPG
Sbjct: 2108 EALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSV 2167
Query: 4980 FKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQ 5036
K +H N+L+Y +P LA +F ++ +K L+I+ YS++QTTL+QVF+NFA +Q
Sbjct: 2168 LKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQ 2224
Score = 184 bits (466), Expect = 3e-45
Identities = 163/600 (27%), Positives = 277/600 (46%), Gaps = 55/600 (9%)
Query: 3585 ASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVL----KTSG 3640
AS V L+ E+ + + + GV PVI++L+ F+ +M + ATL I++ +
Sbjct: 1670 ASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVP-ATLVIIIFICFQQKS 1728
Query: 3641 IFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMI-----SFLPYIV 3695
+ +N ++ L LL +G S+ L Y S F +TA + + V + S +++
Sbjct: 1729 YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVL 1788
Query: 3696 LLVLHNQLSFVN---QTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTF 3752
L N+L+ +N ++ + G+G+ I ++ Q M ALE+ G
Sbjct: 1789 ELFTDNKLNNINDILKSVFLIFPHFCLGRGL--IDMVKNQA-------MADALERFGEN- 1838
Query: 3753 GWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSS 3812
F S L W L F + F + F + R +++
Sbjct: 1839 -------RFVSPL----SWDLVGR--NLFAMAVEGVVFFLITVLIQYRFFIRPRP--VNA 1883
Query: 3813 SLFFFNENFDNKGSSLQNREGELEGSAPG--VTLVSVTKEYEG-HKAVVQDLSLTFYRDQ 3869
L N D + R+ L+G + + +TK Y K V + + +
Sbjct: 1884 KLSPLN---DEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGE 1940
Query: 3870 ITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDN 3929
LLG NGAGK++ MLTG T G +N ++ +++ V +G CPQ D + +
Sbjct: 1941 CFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITEL 2000
Query: 3930 LTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIA 3989
LT REH+ FA ++ +KE+ + ++ + L ++ K SGG KRKLS +A
Sbjct: 2001 LTGREHVEFFALLRGV--PEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMA 2058
Query: 3990 FMGMSRTVVLDEPTSGVDPCSRHSLWDILLK-YREGRTIIFTTHHLDEAEALSDRVAVLQ 4048
+G V LDEPT+G+DP +R LW+ L +EGR+++ T+H ++E EAL R+A++
Sbjct: 2059 LIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMV 2118
Query: 4049 HGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSS 4108
+GR RC G LK +G G + V A D+ V + P + LK+
Sbjct: 2119 NGRFRCLGSVQHLKNRFGDGYTIV------VRIAGSNPDLKPVQDFFGLAFPGSVLKEKH 2172
Query: 4109 GSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSNKKSHI 4168
+ L Y +P + + L +F L ++ +LH+ Y +S TTL++VF+ +D + H+
Sbjct: 2173 RNMLQYQLP--SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHL 2230
Score = 65.1 bits (157), Expect = 2e-09
Identities = 29/83 (34%), Positives = 43/83 (51%)
Query: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCG 66
Q + LLWKN R R L E WP +F+IL +R PP + C+ + +PS G
Sbjct: 6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG 65
Query: 67 VIPFVQSLLCNTGSRCRNFSYEG 89
+P+VQ ++CN + C + G
Sbjct: 66 TLPWVQGIICNANNPCFRYPTPG 88
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 1036 bits (2680), Expect = 0.0
Identities = 715/2149 (33%), Positives = 1105/2149 (51%), Gaps = 207/2149 (9%)
Query: 3068 VKIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSG-KCDQEIL 3126
++I+D++K+ LT L +I +S+ ++ ++ + + + +AL C + +L
Sbjct: 151 IRIRDILKDEETLTLFLIKNIGLSDSVVYLLINSQVRPEQFAHGVPDLALKDIACSEALL 210
Query: 3127 HLLLTFPKGEKSWIAAEELCSLPGSKVYSLIVLLSRNLDVRAF--IYKTLMPSEANGL-L 3183
+ F + + LCSL + + L N+D + TL+ S + G+ L
Sbjct: 211 ERFIIFSQRRGAKTVRYALCSLSQGTLQWIEDTLYANVDFFKLFRVLPTLLDSRSQGINL 270
Query: 3184 NSLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFGSFQ 3243
S I+S +S + EF+H + LL + + + G
Sbjct: 271 RSWGGILSDMSPRIQ----------EFIHRPSMQDLLWVTRPLMQNGGPETFTKLMGILS 320
Query: 3244 FVMKMVCKDQASFLSDSNMFINLPRVKELLEDDKEK---FNIPEDSTPFCLKLYQEILQL 3300
++ + S + N + + L D K ++ +T FC L Q +
Sbjct: 321 DLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCNALIQSLESN 380
Query: 3301 PNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMS-SLFQ 3359
P + W KP+L GKILYTP++P ++++ AN TF ++ ++ L + E+ ++
Sbjct: 381 PLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWY 440
Query: 3360 RSGSGQMFNQLQEALRNKFVRNFVENQLH---IDVDKLTEKLQTYGG----LLDEMFNHA 3412
+ N +++ L N V++F+ QL I + + L Y G D+M N
Sbjct: 441 FFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFL--YKGPRESQADDMANFD 498
Query: 3413 GAGRFRFLGSILVNLSS---CVALNRFQALQSVDILETKAHELLQQNSFLASIIFSNSLF 3469
F L ++ C+ L++F++ L +A LL++N F A ++F +
Sbjct: 499 WRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMY- 557
Query: 3470 DKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYV-FAPLQ 3528
+ LPPHV Y IR ++ +T+ +K+ W P+ P + F+Y + FA LQ
Sbjct: 558 -----PWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQ 612
Query: 3529 DMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMV 3588
DM+E+ I Q EA Q PYPC D F+ + FP+ M+L W+ SV+ V
Sbjct: 613 DMVEQGITRSQVQAEA-PVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTV 671
Query: 3589 RKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTF 3648
+ +V E+E++++E ++ GV + + WFL++ +++++S L I + I +S+ F
Sbjct: 672 KSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPF 731
Query: 3649 IVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQ 3708
I+FLFLL F + +ML +LLS FFS+A+ AA C+ ++Y +LP+I+ ++++ +
Sbjct: 732 ILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELK 791
Query: 3709 TFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGG-MTFGWVCWMILFDSSLYF 3767
+ LLS AFG G ++ E Q G+QW+N+ + +G +F M+L D+++Y
Sbjct: 792 KAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYG 851
Query: 3768 LCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNK--- 3824
L WYL + PG +G PWYF SYW + + L + E D +
Sbjct: 852 LLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPE 911
Query: 3825 GSSLQNREGELEGSAPGVTLVSVTKEYEG-HKAVVQDLSLTFYRDQITALLGTNGAGKTT 3883
G E E G PGV + ++ K +E + V L++TFY +QITA LG NGAGKTT
Sbjct: 912 GIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTT 971
Query: 3884 IISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIK 3943
+S+LTGL PPTSGT+++ G++++T L VR LG+CPQ +IL +LTV EH+L +A +K
Sbjct: 972 TLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLK 1031
Query: 3944 APQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPT 4003
+++E ++ L+D L ++++ + LSGG++RKLS+ IAF+G ++ V+LDEPT
Sbjct: 1032 GK--SQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPT 1089
Query: 4004 SGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKE 4063
SGVDP SR S+WD+LLKYR GRTII +THH+DEA+ L DR+A++ GRL C G P LK
Sbjct: 1090 SGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKN 1149
Query: 4064 AYGQGLRLTLTRQPSVLEAH------------------------DLK-------DMACVT 4092
+G GL LTL R+ +++ DL D+ +
Sbjct: 1150 CFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELM 1209
Query: 4093 SLIKIYIPQAFLKDSSGSELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTL 4151
++ ++P+A L + G EL + +P K+ LF+ L+E L L L+ +GISDT L
Sbjct: 1210 DVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPL 1269
Query: 4152 EEVFLMLLQDSNKKSHIALGTESELQNHRP-------------TGHLSGYCGSLA----- 4193
EE+FL + +DS+ A G + + +N P T S C A
Sbjct: 1270 EEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPAAHP 1329
Query: 4194 -----------RPATVQGVQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMG 4242
P G QL+ V A+L +R + T+R+ K LA ++LP FV LA+
Sbjct: 1330 EGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALM 1389
Query: 4243 LFMVRPLATEYPPLRLTPGHYQRAETYFF--SSGGDNLD-LTRVLLRK--FRDQ------ 4291
L +V P EYP L L P Y + T+F G + L VLL K F ++
Sbjct: 1390 LSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGW 1449
Query: 4292 --DLPCADLNP---------------RQK------NSSC---WRTDPFSHPEFQDSCGCL 4325
+ PC + P +QK + SC R PE + G L
Sbjct: 1450 LPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGL 1509
Query: 4326 KCPNRSASAPYLTNHLGHTLLNLSGFNMEEY--LLAPSEK-------PRLGGWSFGLKIP 4376
P R+ + + L T N+S F ++ Y L+ S K R GG S G K+P
Sbjct: 1510 PPPQRTQRSTEILQDL--TDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLP 1567
Query: 4377 -----SEA-------GGANGNISKPPTL-------------------AKVWYNQKGFHSL 4405
EA G N+S P KVW+N KG+H+L
Sbjct: 1568 VVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHAL 1627
Query: 4406 PSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYG--GALLNKDKILESIRQCGVALCIV 4463
S+LN +N IL LP +YGIT+ S P L++ +L + VA+C++
Sbjct: 1628 VSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVI 1687
Query: 4464 LGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIV 4523
S + AS ++++RV +K LQ ISG+ YW TNFL+D++ Y VS L V + +
Sbjct: 1688 FSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFI 1747
Query: 4524 AFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTM 4583
FQ A+T +NL A LL L+G+A +P MY S +F A+++ N G+ +
Sbjct: 1748 GFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSS 1807
Query: 4584 LITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTHNFGID 4643
IT +L + + L VL+ + +FP FCLG+GL++L +Q D+ FG +
Sbjct: 1808 AITF---ILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEE 1864
Query: 4644 SYVSPFEMNFLGWIFVQLASQGTVLLLLRVLL--HWDLLRWPRGHSTLQGTVKSSKDTDV 4701
+PF + +G + +G V LL +L+ H+ L +W T + V +D DV
Sbjct: 1865 HSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQW-IAEPTKEPIV--DEDDDV 1921
Query: 4702 EKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKS 4761
+E +R+ G DIL L+ L+K Y + AV + +G+ GECFGLLGVNGAGK+
Sbjct: 1922 AEERQRIITGGNKTDILRLHELTKIYPG--TSSPAVDRLCVGVRPGECFGLLGVNGAGKT 1979
Query: 4762 TTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYY 4821
TTFKML G+ ++TSG A T G ++ L++ +GYCPQ DA+DELLTG EHLY
Sbjct: 1980 TTFKMLTGDTTVTSGDA---TVAGKSI-LTNISEVHQNMGYCPQFDAIDELLTGREHLYL 2035
Query: 4822 YCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLD 4881
Y LRG+P + I +VA I+ L L +AD TYSGG KRKLSTA+AL+G P ++LLD
Sbjct: 2036 YARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLD 2095
Query: 4882 EPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQ 4941
EP++GMDP ++R LW I+ +REG A VLTSHSMEECEALCTRLAIMV G+F+C+G+ Q
Sbjct: 2096 EPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQ 2155
Query: 4942 HIKNRFGDGYTVKVWLCKEANQHC----TVSDHLKLYFPGIQFKGQHLNLLEYHVPKRWG 4997
H+K++FGDGY V + + + V + FPG + +H N+L++ V
Sbjct: 2156 HLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSS--S 2213
Query: 4998 CLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTLQSTLDP 5046
LA +F+++ ++K L I+ YS+ QTTL+QVF+NFA +Q ++ L P
Sbjct: 2214 SLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHP 2262
Score = 67.4 bits (163), Expect = 3e-10
Identities = 37/135 (27%), Positives = 62/135 (45%), Gaps = 12/135 (8%)
Query: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCG 66
Q + LLWKNW R R + F+ E WP LF++L LR P C+ + +PS G
Sbjct: 6 QIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAG 65
Query: 67 VIPFVQSLLCNTGSRCRNFSYEGSMEHHFRLSRFQTAADPKKVNNLAFLKEIQDLAEEIH 126
++P++Q + CN + C G ++ NN + +D +E+
Sbjct: 66 MLPWLQGIFCNVNNPCFQSPTPG-----------ESPGIVSNYNNSILARVYRDF-QELL 113
Query: 127 GMMDKAKNLKRLWVE 141
++++L R+W E
Sbjct: 114 MNAPESQHLGRIWTE 128
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 980 bits (2533), Expect = 0.0
Identities = 671/1995 (33%), Positives = 997/1995 (49%), Gaps = 189/1995 (9%)
Query: 3182 LLNSLLDIVSSLSALLAKAQHVFEYLPEFLHTF--KITALLETLDFQQVSQNVQARSSAF 3239
LL SLL SL L +AQ L E ++ AL ++ + + Q + S
Sbjct: 159 LLTSLLR-TESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTS--- 214
Query: 3240 GSFQFVMKMVC--KDQASFLSDSNMFINLPRVKELLEDDKEKFNIPEDSTPFCLKLYQEI 3297
G + + + +C + +S + S + + EL+ + E +P C +L +
Sbjct: 215 GPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSELIGAL 274
Query: 3298 LQLPNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSS- 3356
P L+W LKP++ GK+L+ P+TP K++ + N TF + L+ + E +
Sbjct: 275 DSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPR 334
Query: 3357 LFQRSGSGQMFNQLQEALRNKFVRNFVENQLHID-VDKLTEKLQTYGGLLDEMFNHAGAG 3415
+F LQ L+ + D ++ L L G HA G
Sbjct: 335 IFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVG 394
Query: 3416 RFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIF--SNSLFDKNF 3473
L L ++ C++L++ +A S L ++A +LL ++ F A ++F D
Sbjct: 395 H---LVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTE 451
Query: 3474 RSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYV-FAPLQDMIE 3532
P HV IR ++ RT+ +++ W P P +Y + F LQD++E
Sbjct: 452 HPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVE 511
Query: 3533 RAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLV 3592
RA + V +G Q PYPC+ D+FL + PL + L W+ SV V+ +V
Sbjct: 512 RAAVRVLSGANP-RAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVV 570
Query: 3593 YEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFL 3652
E+E ++ + MR MG+ + +L WFL + +S+A L +VLK I +S+ +VFL
Sbjct: 571 REKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFL 630
Query: 3653 FLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLC 3712
FL F ++ V S+LLSAFFS+AN AA C L Y +LPY++ + ++L +
Sbjct: 631 FLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAAS 690
Query: 3713 LLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWY 3772
LLS AFG G + LE Q G QW+N+ + V ++L D++LY L WY
Sbjct: 691 LLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWY 750
Query: 3773 LSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNRE 3832
L + PG +G+ +PW FPF SYW G K + L D K E
Sbjct: 751 LEAVCPGQYGIPEPWNFPFRRSYW--CGPRPPKSPAPCPTPL-------DPKVLV----E 797
Query: 3833 GELEGSAPGVTLVSVTKEYEGH-KAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGL 3891
G +PGV++ S+ K + G + ++ LSL FY+ ITA LG NGAGKTT +S+L+GL
Sbjct: 798 EAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGL 857
Query: 3892 HPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKE 3951
PP+ G+ I G ++++ ++ +R LGVCPQ ++L D LTV EH+ + +K +
Sbjct: 858 FPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKG--LSAAV 915
Query: 3952 LHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSR 4011
+ + ++ LQDV L Q QTR LSGG++RKLS+ IAF+G S+ V+LDEPT+GVDP SR
Sbjct: 916 VGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASR 975
Query: 4012 HSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRL 4071
+W++LLKYREGRT+I +THHLDEAE L DRVAV+ GRL CCG P L+ G G L
Sbjct: 976 RGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYL 1035
Query: 4072 TLTRQPSVLEAHDLKDMAC-----------------------VTSLIKIYIPQAFLKDSS 4108
TL + L ++ D + +L++ ++P A L +
Sbjct: 1036 TLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEEL 1095
Query: 4109 GSELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLML--------- 4158
EL +P LF+ LD L +L LTGYGISDT+LEE+FL +
Sbjct: 1096 PHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTD 1155
Query: 4159 LQDSNKKSHIALGT--------------ESELQNHRPTGHLSGYCGSLARPAT--VQGVQ 4202
++D + H+ G E+ L+N P G A VQG
Sbjct: 1156 MEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWA 1215
Query: 4203 LLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGH 4262
L R Q+ A+L +R R+ + A ++LP LFV LA+ ++ P YP LRL+P
Sbjct: 1216 LTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTM 1275
Query: 4263 YQRAETYFFSSGGDNLDLTRVLLRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEF---- 4318
Y ++F + R+L ++ L P ++SS FS PE
Sbjct: 1276 YGAQVSFFSEDAPGDPGRARLLEALLQEAGLE----EPPVQHSS----HRFSAPEVPAEV 1327
Query: 4319 --------------QDSCGCLK---------CPNRSASAP--YLTNHLGHTLLNLSGFNM 4353
+C C + CP + P G + NL+G N+
Sbjct: 1328 AKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNL 1387
Query: 4354 EEYLLAPSEK--------------PRLGGWSFGLKIPSEA-------------------- 4379
++L+ + R GG+S G + P
Sbjct: 1388 SDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLP 1447
Query: 4380 GGANGNISKPPTL----------AKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQ 4429
GGA + K T K+W+N KG+HS+ +++N +N IL HLPP
Sbjct: 1448 GGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHA 1507
Query: 4430 YGITLYSHPYGGALLNKDKILESIRQCG-----VALCIVLGFSILSASIGSSVVRDRVIG 4484
+ IT +HP L K+++ E V++C+V S + AS ++ +RV
Sbjct: 1508 HSITTLNHPLN---LTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTR 1564
Query: 4485 AKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLS 4544
AK LQ + GL +YW NFL+DM YLV C+ V + +AFQ A+ NL A LLL
Sbjct: 1565 AKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLL 1624
Query: 4545 LFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNI 4604
L+G++ P MY S FS A++ +N G+ + T + L + + LQ +
Sbjct: 1625 LYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFS----DQKLQEV 1680
Query: 4605 YDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQ 4664
+LK VF IFP FCLG+GL+++ NQ D G + SP +G + + Q
Sbjct: 1681 SRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQ 1740
Query: 4665 GTVLLLLRVLLHW--DLLRWPRGHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYN 4722
G + LL +LL LL PR S + +D DV +E +RV +G T GD+LVL N
Sbjct: 1741 GPLFLLFTLLLQHRSQLLPQPRVRSL---PLLGEEDEDVARERERVVQGATQGDVLVLRN 1797
Query: 4723 LSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRT 4782
L+K YR Q + AV + LGIP GECFGLLGVNGAGK++TF+M+ G+ + G A++
Sbjct: 1798 LTKVYRG--QRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLA- 1854
Query: 4783 PMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIR 4842
G +V A + +GYCPQ DA+ ELLTG EHL LRG+P + + AG +
Sbjct: 1855 --GHSV-AREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLA 1911
Query: 4843 RLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKE 4902
RL L +AD+P TYSGG KRKL+TALALVG P ++ LDEP++GMDP ++R+LW +++
Sbjct: 1912 RLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAV 1971
Query: 4903 VREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEAN 4962
VREG + +LTSHSMEECEALC+RLAIMVNG F+CLGSPQH+K RF G+T+ + + +
Sbjct: 1972 VREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARS 2031
Query: 4963 QHCTVSDHLKLYFPGIQFKGQHLNLLEYHVPKRWGC-LADLFKVIENNKTFLNIKHYSIN 5021
Q + + FPG + + H L + +P C LA +F + + ++ +S++
Sbjct: 2032 Q--PAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVS 2089
Query: 5022 QTTLEQVFINFASEQ 5036
QT LE+VF+ F+ +Q
Sbjct: 2090 QTMLEEVFLYFSKDQ 2104
Score = 179 bits (455), Expect = 5e-44
Identities = 163/622 (26%), Positives = 278/622 (44%), Gaps = 64/622 (10%)
Query: 3563 LFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENM 3622
L ++V + ++ AS L+ E+ + + M G+ P +++L FL +M
Sbjct: 1529 LMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDM 1588
Query: 3623 AVLTISSATLAIVL---KTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAA 3679
+ + + ++ + A +N + L LL +G S+ L Y S FFS +TA
Sbjct: 1589 CNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAY 1648
Query: 3680 LCTSLVYMI-----SFLPYIVLLVLHNQLSFVN----QTFLCLLSTTAFGQGVFFITFLE 3730
+ + + + S +++ L +L V+ Q FL + G+G+ I +
Sbjct: 1649 VVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFL-IFPHFCLGRGL--IDMVR 1705
Query: 3731 GQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFP 3790
Q + + Q + W ++ + L + ++ P +
Sbjct: 1706 NQAMADAFERLGDRQFQSPLR-----WEVVGKNLLAMV--------------IQGPLFLL 1746
Query: 3791 FTASYWKSVGFLVEKRQYFLSS----SLFFFNENFDNKGSSLQNREGELEGSAPGVTLV- 3845
FT L++ R L SL E ++ + RE ++G+ G LV
Sbjct: 1747 FT--------LLLQHRSQLLPQPRVRSLPLLGEEDEDVA---RERERVVQGATQGDVLVL 1795
Query: 3846 -SVTKEYEGHKAVVQD-LSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIING 3903
++TK Y G + D L L + LLG NGAGKT+ M+TG + G ++ G
Sbjct: 1796 RNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAG 1855
Query: 3904 KNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDV 3963
++ + S + +G CPQ D + + LT REHL L A ++ + ++ Q L +
Sbjct: 1856 HSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGV--PEAQVAQTAGSGLARL 1913
Query: 3964 DLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLK-YR 4022
L+ + + SGG KRKL+ +A +G V LDEPT+G+DP +R LW+ LL R
Sbjct: 1914 GLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVR 1973
Query: 4023 EGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEA 4082
EGR+++ T+H ++E EAL R+A++ +GR RC G P LK + G LTL R P+
Sbjct: 1974 EGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL-RVPAARSQ 2032
Query: 4083 HDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLT 4142
+ + P A L+++ G L + +P + L +F L + + +
Sbjct: 2033 P-------AAAFVAAEFPGAELREAHGGRLRFQLPPG-GRCALARVFGELAVHGAEHGVE 2084
Query: 4143 GYGISDTTLEEVFLMLLQDSNK 4164
+ +S T LEEVFL +D K
Sbjct: 2085 DFSVSQTMLEEVFLYFSKDQGK 2106
Score = 75.1 bits (183), Expect = 2e-12
Identities = 38/94 (40%), Positives = 48/94 (51%), Gaps = 2/94 (2%)
Query: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCG 66
Q LLWKN++ R R PV L E WP LF IL +R PP C+ + LPS G
Sbjct: 6 QLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAG 65
Query: 67 VIPFVQSLLCNTGSRCRNFSYEGSMEHHFRLSRF 100
+P++Q L+CN + C F E RLS F
Sbjct: 66 TVPWLQGLICNVNNTC--FPQLTPGEEPGRLSNF 97
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 514 bits (1325), Expect = e-145
Identities = 305/929 (32%), Positives = 513/929 (55%), Gaps = 76/929 (8%)
Query: 3317 KILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSSLFQRSGSGQMFNQLQEALRN 3376
KILY P E+++VI KAN TF V + ++ L +S+ RS Q +LQ+ LR
Sbjct: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEI-RSFLEQ--GRLQQHLR- 514
Query: 3377 KFVRNFV-ENQLH-----IDVDKLTEKLQTYG-------GLLDEM--FNHAGAGRFRFLG 3421
+++ +V E +LH + +D+L L+ LL ++ ++A G +F+
Sbjct: 515 -WLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQFMS 573
Query: 3422 SILVNLSSCVALNRFQALQSVD-ILETKAHELLQQN-SFLASIIFSNSLFDKNFRSESVK 3479
+ V++ F+ + I+ ++ Q N + AS+IF +
Sbjct: 574 KVSVDI--------FKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTR--------KDGS 617
Query: 3480 LPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPLQDMIERAIILVQ 3539
LPPHV Y IR N ++ +T+ ++ W+ P F + Y F +QDM+ERAII
Sbjct: 618 LPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNT--GGRFYFLYGFVWIQDMMERAIIDTF 675
Query: 3540 TGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQI 3599
G + +EP + Q PYPC+T D FL + PL M+++W+ SVA ++ +V E+E ++
Sbjct: 676 VGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRL 735
Query: 3600 EEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGM 3659
+E M+ MG++ +H++AWF+ L+IS L +LK + HS+ I++LFL + +
Sbjct: 736 KEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAV 795
Query: 3660 SVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLL----VLHNQLSFVNQTFLCLLS 3715
+ +M +L+S +S+A A+ C ++Y +S++PY+ + V H++++ + L+S
Sbjct: 796 ATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMS 855
Query: 3716 TTAFGQGVFFITFLEGQETGIQWNNMYQA-LEQGGMTFGWVCWMILFDSSLYFLCGWYLS 3774
TTAFG G + E GIQW+ Q+ +E M++ D+ +Y + WY+
Sbjct: 856 TTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIE 915
Query: 3775 NLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGE 3834
+ PG +GL +PWYFP SYW G + + + +++ ++++R E
Sbjct: 916 AVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFE 975
Query: 3835 ----LEGSAPGVTLV----SVTKEY-EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTII 3885
+E + LV +TK Y + K + LSL Y +Q+ + LG NGAGKTT +
Sbjct: 976 ETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTM 1035
Query: 3886 SMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAP 3945
S+LTGL PPTSG+ I G +++T++ +R LG+CPQ ++L D LTV EHL ++ +K+
Sbjct: 1036 SILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKS- 1094
Query: 3946 QWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSG 4005
++E+ +++++ ++D++L+ +H + LSGG+KRKLS+ IAF+G SR ++LDEPT+G
Sbjct: 1095 -MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAG 1153
Query: 4006 VDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAY 4065
VDP +R ++WD++LKY+ GRTI+ +THH+DEA+ L DR+A++ HG+L+CCG P LK Y
Sbjct: 1154 VDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTY 1213
Query: 4066 GQGLRLTLTRQPSVLEAHDLKDMAC---------------VTSLIKIYIPQAFLKDSSGS 4110
G G RLTL ++P+ +A V+ I+ ++ L + +
Sbjct: 1214 GDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTST 1273
Query: 4111 ELTYTIPKD-TDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQD----SNKK 4165
EL+Y +P + K + LFQ L+ +L LHL+ +G+ DTTLEEVFL + ++ N +
Sbjct: 1274 ELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSE 1333
Query: 4166 SHIALGTESELQNHRPTGHLSGYCGSLAR 4194
+ + + L G+ G+LAR
Sbjct: 1334 ADVKESRKDVLPGAEGPASGEGHAGNLAR 1362
Score = 466 bits (1199), Expect = e-130
Identities = 332/956 (34%), Positives = 473/956 (49%), Gaps = 131/956 (13%)
Query: 4207 QVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPP----------- 4255
Q +L +R R K+ + +LLP FV +AM + + P + PP
Sbjct: 1439 QFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNY 1498
Query: 4256 -------------------LRLTP--GHYQRAETYFFSSG---------------GDNLD 4279
LRL+P Q T+ SG G L+
Sbjct: 1499 TQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLN 1558
Query: 4280 LT----RVLLRKFRD--------QDLPCADLNPR-------------QKNSSCWRTD--P 4312
L+ R+L +F D Q LP ++ P ++ W P
Sbjct: 1559 LSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPP 1618
Query: 4313 FSHPEFQDS-------------CGC------LKCPNR-SASAPYLTNHLGHTLLNLSGFN 4352
+ PE S C C CP+ P + G L +++G N
Sbjct: 1619 TAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHN 1678
Query: 4353 MEEYLLAPSEKPRL---GGWSFGLKIPSEAGGANGNISKPPTL--------AKVWYNQKG 4401
+ EYLL S++ RL G +FG + S A+ PP + A+V+YN KG
Sbjct: 1679 VSEYLLFTSDRFRLHRYGAITFGNVLKSIP--ASFGTRAPPMVRKIAVRRAAQVFYNNKG 1736
Query: 4402 FHSLPSYLNHLNNLILWQHLPPTV-DWRQYGITLYSHPYG--GALLNKDKILESIRQCGV 4458
+HS+P+YLN LNN IL +LP + + YGIT+ +HP A L+ D +L+ +
Sbjct: 1737 YHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGT-DVVI 1795
Query: 4459 ALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLC 4518
A+ I++ S + AS +V ++ AK LQ +SG +YW N+++DML YLV C
Sbjct: 1796 AIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCC 1855
Query: 4519 VAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIF 4578
V ++ F L A+T N A L L+G++ P MY S F A++ + +N
Sbjct: 1856 VIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFI 1915
Query: 4579 GLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTH 4638
G+ + T LL + K+L+ + LK F IFP + LG GL+E+ YN+ +
Sbjct: 1916 GITATVATF---LLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYA 1972
Query: 4639 NFG-IDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPRGHSTLQGTVKSSK 4697
G D SPFE + + V +A +G V LL ++ ++ LR P+ V+
Sbjct: 1973 KIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVED-- 2030
Query: 4698 DTDVEKEEKRVFEGRTNGDILVLYNLSKHYR-RFFQNIIAVQDISLGIPKGECFGLLGVN 4756
D DV E +RV G + D++ + NL+K Y+ R I+AV + LG+ GECFGLLGVN
Sbjct: 2031 DVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVN 2090
Query: 4757 GAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGW 4816
GAGK++TFKML G+ S T G A + G +V L +GYCPQ DAL + LT
Sbjct: 2091 GAGKTSTFKMLTGDESTTGGEAFVN---GHSV-LKELLQVQQSLGYCPQCDALFDELTAR 2146
Query: 4817 EHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPD 4876
EHL Y LRGI + V + +L L +ADKP TYSGG KRKLSTA+AL+G P
Sbjct: 2147 EHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPA 2206
Query: 4877 ILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKC 4936
+ LDEP++GMDP ++R+LW I+ ++ G + VLTSHSMEECEALCTRLAIMVNG +C
Sbjct: 2207 FIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRC 2266
Query: 4937 LGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLY---FPGIQFKGQHLNLLEYHVP 4993
LGS QH+KNRFGDGY + V +V D ++ + FP K +H ++Y +
Sbjct: 2267 LGSIQHLKNRFGDGYMITV----RTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLK 2322
Query: 4994 KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTL--QSTLDPS 5047
LA +F +E L I+ YS++QTTL+ VF+NFA +Q L Q T PS
Sbjct: 2323 SEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPS 2378
Score = 195 bits (495), Expect = 1e-48
Identities = 166/617 (26%), Positives = 287/617 (46%), Gaps = 64/617 (10%)
Query: 3562 DLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLEN 3621
D L + +++ AS V LV E+ + + + G +P+I++LA ++ +
Sbjct: 1785 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
Query: 3622 MAVLTISSATLAIVLKTSGIFAHSNTF----IVFLFLLDFGMSVVMLSYLLSAFFSQANT 3677
M + + I+L + A+++ ++ LFLL +G S+ + Y S +F ++
Sbjct: 1845 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLL-YGWSITPIMYPASFWFEVPSS 1903
Query: 3678 AALCTSLVYMI-----SFLPYIVLLVLHNQLSFVNQTFL--CLLSTTAF--GQGVFFITF 3728
A + ++ + + +++ L H++ V ++L C L + G G+ + +
Sbjct: 1904 AYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAY 1963
Query: 3729 LEGQETGI----QWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLR 3784
E Q++ M E +T G V + + G+ L+ + F LR
Sbjct: 1964 NEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAV------EGVVGFLLTIMCQYNF-LR 2016
Query: 3785 KPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGSAPGVTL 3844
+P P + + + +RQ L DN ++N
Sbjct: 2017 RPQRMPVSTKPVEDDVDVASERQRVLRGDA-------DNDMVKIEN-------------- 2055
Query: 3845 VSVTKEYEGHKA----VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTII 3900
+TK Y+ K V L L + LLG NGAGKT+ MLTG T G
Sbjct: 2056 --LTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAF 2113
Query: 3901 INGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTL 3960
+NG ++ +L +V+ LG CPQ D L D LT REHL L+ ++ W K+ + V L
Sbjct: 2114 VNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW--KDEARVVKWAL 2171
Query: 3961 QDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLK 4020
+ ++LT++ K SGG KRKLS IA +G + LDEPT+G+DP +R LW+++L
Sbjct: 2172 EKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILD 2231
Query: 4021 -YREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSV 4079
+ GR+++ T+H ++E EAL R+A++ +GRLRC G LK +G G +T+ + S
Sbjct: 2232 LIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSS- 2290
Query: 4080 LEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQL 4139
+KD V P+A LK+ +++ Y + ++ L +F +++ L
Sbjct: 2291 ---QSVKD---VVRFFNRNFPEAMLKERHHTKVQYQL--KSEHISLAQVFSKMEQVSGVL 2342
Query: 4140 HLTGYGISDTTLEEVFL 4156
+ Y +S TTL+ VF+
Sbjct: 2343 GIEDYSVSQTTLDNVFV 2359
Score = 158 bits (399), Expect = 1e-37
Identities = 165/647 (25%), Positives = 276/647 (42%), Gaps = 82/647 (12%)
Query: 4460 LCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCV 4519
LC+V+ + A +V ++ K + GL ++W F+ + +SV
Sbjct: 710 LCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALT 769
Query: 4520 AVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVA--------FISY 4571
A++ Q+ ++ L L+++ AT+ + +L+S ++S + +A F+SY
Sbjct: 770 AILKYGQVL---MHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSY 826
Query: 4572 VSLNFIF---GLCTMLITIMPRLLAII--SKAKNLQNIYDVLKWVFTIFPQF-CLGQGLV 4625
V ++ + IT + +A + + A L + Y L V + Q+ Q V
Sbjct: 827 VPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPV 886
Query: 4626 E-------LCYNQIKYDLTHNFGIDSYVSPFEMNFLG----WIFVQLASQGTVLLLLRVL 4674
E L + D + Y+ G W F Q + L
Sbjct: 887 EGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYF---PLQKSYWLGSGRT 943
Query: 4675 LHWDLLRWPRGHSTLQGTVKSSKDTDVEK---EEKRVFEGRTNGDILVLY--NLSKHYRR 4729
W+ WP + ++ + +E EE R E LV+ L+K Y+
Sbjct: 944 EAWEW-SWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKD 1002
Query: 4730 FFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAII-----RTPM 4784
+A+ +SL + + + LG NGAGK+TT +L G TSG A I RT M
Sbjct: 1003 --DKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
Query: 4785 GDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRL 4844
D + + +G CPQ + L + LT EHL++Y L+ + ++ I +I L
Sbjct: 1061 -DEIRKN--------LGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDL 1111
Query: 4845 HLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVR 4904
L V T SGG KRKLS A+A VG ++LDEP++G+DP ++R +W I+K +
Sbjct: 1112 ELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK-YK 1170
Query: 4905 EGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQ- 4963
G +L++H M+E + L R+AI+ +G KC GSP +K +GDGY ++ L K +
Sbjct: 1171 PGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGY--RLTLVKRPAEP 1228
Query: 4964 ----------------------HCTVSDHLKLYFPGIQFKGQHLNLLEYHVPK---RWGC 4998
VS ++ + L Y +P + G
Sbjct: 1229 GGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGA 1288
Query: 4999 LADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTLQSTLD 5045
LF+ +E + L++ + + TTLE+VF+ + E Q S D
Sbjct: 1289 FERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEAD 1335
Score = 48.9 bits (115), Expect = 1e-04
Identities = 28/76 (36%), Positives = 42/76 (55%), Gaps = 2/76 (2%)
Query: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPP-RYRDICYLQPRDLPSC 65
Q + LLWKN + R+P + E F P +LF IL LR ++P +++ + L S
Sbjct: 6 QLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSA 65
Query: 66 GVIPFVQSLLCNTGSR 81
G++P +QS LC G R
Sbjct: 66 GILPVMQS-LCPDGQR 80
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 514 bits (1325), Expect = e-145
Identities = 305/929 (32%), Positives = 513/929 (55%), Gaps = 76/929 (8%)
Query: 3317 KILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSSLFQRSGSGQMFNQLQEALRN 3376
KILY P E+++VI KAN TF V + ++ L +S+ RS Q +LQ+ LR
Sbjct: 489 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEI-RSFLEQ--GRLQQHLR- 544
Query: 3377 KFVRNFV-ENQLH-----IDVDKLTEKLQTYG-------GLLDEM--FNHAGAGRFRFLG 3421
+++ +V E +LH + +D+L L+ LL ++ ++A G +F+
Sbjct: 545 -WLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQFMS 603
Query: 3422 SILVNLSSCVALNRFQALQSVD-ILETKAHELLQQN-SFLASIIFSNSLFDKNFRSESVK 3479
+ V++ F+ + I+ ++ Q N + AS+IF +
Sbjct: 604 KVSVDI--------FKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTR--------KDGS 647
Query: 3480 LPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPLQDMIERAIILVQ 3539
LPPHV Y IR N ++ +T+ ++ W+ P F + Y F +QDM+ERAII
Sbjct: 648 LPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNT--GGRFYFLYGFVWIQDMMERAIIDTF 705
Query: 3540 TGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQI 3599
G + +EP + Q PYPC+T D FL + PL M+++W+ SVA ++ +V E+E ++
Sbjct: 706 VGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRL 765
Query: 3600 EEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGM 3659
+E M+ MG++ +H++AWF+ L+IS L +LK + HS+ I++LFL + +
Sbjct: 766 KEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAV 825
Query: 3660 SVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLL----VLHNQLSFVNQTFLCLLS 3715
+ +M +L+S +S+A A+ C ++Y +S++PY+ + V H++++ + L+S
Sbjct: 826 ATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMS 885
Query: 3716 TTAFGQGVFFITFLEGQETGIQWNNMYQA-LEQGGMTFGWVCWMILFDSSLYFLCGWYLS 3774
TTAFG G + E GIQW+ Q+ +E M++ D+ +Y + WY+
Sbjct: 886 TTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIE 945
Query: 3775 NLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGE 3834
+ PG +GL +PWYFP SYW G + + + +++ ++++R E
Sbjct: 946 AVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFE 1005
Query: 3835 ----LEGSAPGVTLV----SVTKEY-EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTII 3885
+E + LV +TK Y + K + LSL Y +Q+ + LG NGAGKTT +
Sbjct: 1006 ETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTM 1065
Query: 3886 SMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAP 3945
S+LTGL PPTSG+ I G +++T++ +R LG+CPQ ++L D LTV EHL ++ +K+
Sbjct: 1066 SILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKS- 1124
Query: 3946 QWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSG 4005
++E+ +++++ ++D++L+ +H + LSGG+KRKLS+ IAF+G SR ++LDEPT+G
Sbjct: 1125 -MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAG 1183
Query: 4006 VDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAY 4065
VDP +R ++WD++LKY+ GRTI+ +THH+DEA+ L DR+A++ HG+L+CCG P LK Y
Sbjct: 1184 VDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTY 1243
Query: 4066 GQGLRLTLTRQPSVLEAHDLKDMAC---------------VTSLIKIYIPQAFLKDSSGS 4110
G G RLTL ++P+ +A V+ I+ ++ L + +
Sbjct: 1244 GDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTST 1303
Query: 4111 ELTYTIPKD-TDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQD----SNKK 4165
EL+Y +P + K + LFQ L+ +L LHL+ +G+ DTTLEEVFL + ++ N +
Sbjct: 1304 ELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSE 1363
Query: 4166 SHIALGTESELQNHRPTGHLSGYCGSLAR 4194
+ + + L G+ G+LAR
Sbjct: 1364 ADVKESRKDVLPGAEGPASGEGHAGNLAR 1392
Score = 466 bits (1199), Expect = e-130
Identities = 332/956 (34%), Positives = 473/956 (49%), Gaps = 131/956 (13%)
Query: 4207 QVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPP----------- 4255
Q +L +R R K+ + +LLP FV +AM + + P + PP
Sbjct: 1469 QFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNY 1528
Query: 4256 -------------------LRLTP--GHYQRAETYFFSSG---------------GDNLD 4279
LRL+P Q T+ SG G L+
Sbjct: 1529 TQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLN 1588
Query: 4280 LT----RVLLRKFRD--------QDLPCADLNPR-------------QKNSSCWRTD--P 4312
L+ R+L +F D Q LP ++ P ++ W P
Sbjct: 1589 LSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPP 1648
Query: 4313 FSHPEFQDS-------------CGC------LKCPNR-SASAPYLTNHLGHTLLNLSGFN 4352
+ PE S C C CP+ P + G L +++G N
Sbjct: 1649 TAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHN 1708
Query: 4353 MEEYLLAPSEKPRL---GGWSFGLKIPSEAGGANGNISKPPTL--------AKVWYNQKG 4401
+ EYLL S++ RL G +FG + S A+ PP + A+V+YN KG
Sbjct: 1709 VSEYLLFTSDRFRLHRYGAITFGNVLKSIP--ASFGTRAPPMVRKIAVRRAAQVFYNNKG 1766
Query: 4402 FHSLPSYLNHLNNLILWQHLPPTV-DWRQYGITLYSHPYG--GALLNKDKILESIRQCGV 4458
+HS+P+YLN LNN IL +LP + + YGIT+ +HP A L+ D +L+ +
Sbjct: 1767 YHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGT-DVVI 1825
Query: 4459 ALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLC 4518
A+ I++ S + AS +V ++ AK LQ +SG +YW N+++DML YLV C
Sbjct: 1826 AIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCC 1885
Query: 4519 VAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIF 4578
V ++ F L A+T N A L L+G++ P MY S F A++ + +N
Sbjct: 1886 VIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFI 1945
Query: 4579 GLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTH 4638
G+ + T LL + K+L+ + LK F IFP + LG GL+E+ YN+ +
Sbjct: 1946 GITATVATF---LLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYA 2002
Query: 4639 NFG-IDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPRGHSTLQGTVKSSK 4697
G D SPFE + + V +A +G V LL ++ ++ LR P+ V+
Sbjct: 2003 KIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVED-- 2060
Query: 4698 DTDVEKEEKRVFEGRTNGDILVLYNLSKHYR-RFFQNIIAVQDISLGIPKGECFGLLGVN 4756
D DV E +RV G + D++ + NL+K Y+ R I+AV + LG+ GECFGLLGVN
Sbjct: 2061 DVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVN 2120
Query: 4757 GAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGW 4816
GAGK++TFKML G+ S T G A + G +V L +GYCPQ DAL + LT
Sbjct: 2121 GAGKTSTFKMLTGDESTTGGEAFVN---GHSV-LKELLQVQQSLGYCPQCDALFDELTAR 2176
Query: 4817 EHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPD 4876
EHL Y LRGI + V + +L L +ADKP TYSGG KRKLSTA+AL+G P
Sbjct: 2177 EHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPA 2236
Query: 4877 ILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKC 4936
+ LDEP++GMDP ++R+LW I+ ++ G + VLTSHSMEECEALCTRLAIMVNG +C
Sbjct: 2237 FIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRC 2296
Query: 4937 LGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLY---FPGIQFKGQHLNLLEYHVP 4993
LGS QH+KNRFGDGY + V +V D ++ + FP K +H ++Y +
Sbjct: 2297 LGSIQHLKNRFGDGYMITV----RTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLK 2352
Query: 4994 KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTL--QSTLDPS 5047
LA +F +E L I+ YS++QTTL+ VF+NFA +Q L Q T PS
Sbjct: 2353 SEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPS 2408
Score = 195 bits (495), Expect = 1e-48
Identities = 166/617 (26%), Positives = 287/617 (46%), Gaps = 64/617 (10%)
Query: 3562 DLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLEN 3621
D L + +++ AS V LV E+ + + + G +P+I++LA ++ +
Sbjct: 1815 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1874
Query: 3622 MAVLTISSATLAIVLKTSGIFAHSNTF----IVFLFLLDFGMSVVMLSYLLSAFFSQANT 3677
M + + I+L + A+++ ++ LFLL +G S+ + Y S +F ++
Sbjct: 1875 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLL-YGWSITPIMYPASFWFEVPSS 1933
Query: 3678 AALCTSLVYMI-----SFLPYIVLLVLHNQLSFVNQTFL--CLLSTTAF--GQGVFFITF 3728
A + ++ + + +++ L H++ V ++L C L + G G+ + +
Sbjct: 1934 AYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAY 1993
Query: 3729 LEGQETGI----QWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLR 3784
E Q++ M E +T G V + + G+ L+ + F LR
Sbjct: 1994 NEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAV------EGVVGFLLTIMCQYNF-LR 2046
Query: 3785 KPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGSAPGVTL 3844
+P P + + + +RQ L DN ++N
Sbjct: 2047 RPQRMPVSTKPVEDDVDVASERQRVLRGDA-------DNDMVKIEN-------------- 2085
Query: 3845 VSVTKEYEGHKA----VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTII 3900
+TK Y+ K V L L + LLG NGAGKT+ MLTG T G
Sbjct: 2086 --LTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAF 2143
Query: 3901 INGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTL 3960
+NG ++ +L +V+ LG CPQ D L D LT REHL L+ ++ W K+ + V L
Sbjct: 2144 VNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW--KDEARVVKWAL 2201
Query: 3961 QDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLK 4020
+ ++LT++ K SGG KRKLS IA +G + LDEPT+G+DP +R LW+++L
Sbjct: 2202 EKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILD 2261
Query: 4021 -YREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSV 4079
+ GR+++ T+H ++E EAL R+A++ +GRLRC G LK +G G +T+ + S
Sbjct: 2262 LIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSS- 2320
Query: 4080 LEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQL 4139
+KD V P+A LK+ +++ Y + ++ L +F +++ L
Sbjct: 2321 ---QSVKD---VVRFFNRNFPEAMLKERHHTKVQYQL--KSEHISLAQVFSKMEQVSGVL 2372
Query: 4140 HLTGYGISDTTLEEVFL 4156
+ Y +S TTL+ VF+
Sbjct: 2373 GIEDYSVSQTTLDNVFV 2389
Score = 158 bits (399), Expect = 1e-37
Identities = 165/647 (25%), Positives = 276/647 (42%), Gaps = 82/647 (12%)
Query: 4460 LCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCV 4519
LC+V+ + A +V ++ K + GL ++W F+ + +SV
Sbjct: 740 LCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALT 799
Query: 4520 AVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVA--------FISY 4571
A++ Q+ ++ L L+++ AT+ + +L+S ++S + +A F+SY
Sbjct: 800 AILKYGQVL---MHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSY 856
Query: 4572 VSLNFIF---GLCTMLITIMPRLLAII--SKAKNLQNIYDVLKWVFTIFPQF-CLGQGLV 4625
V ++ + IT + +A + + A L + Y L V + Q+ Q V
Sbjct: 857 VPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPV 916
Query: 4626 E-------LCYNQIKYDLTHNFGIDSYVSPFEMNFLG----WIFVQLASQGTVLLLLRVL 4674
E L + D + Y+ G W F Q + L
Sbjct: 917 EGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYF---PLQKSYWLGSGRT 973
Query: 4675 LHWDLLRWPRGHSTLQGTVKSSKDTDVEK---EEKRVFEGRTNGDILVLY--NLSKHYRR 4729
W+ WP + ++ + +E EE R E LV+ L+K Y+
Sbjct: 974 EAWEW-SWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKD 1032
Query: 4730 FFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAII-----RTPM 4784
+A+ +SL + + + LG NGAGK+TT +L G TSG A I RT M
Sbjct: 1033 --DKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1090
Query: 4785 GDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRL 4844
D + + +G CPQ + L + LT EHL++Y L+ + ++ I +I L
Sbjct: 1091 -DEIRKN--------LGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDL 1141
Query: 4845 HLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVR 4904
L V T SGG KRKLS A+A VG ++LDEP++G+DP ++R +W I+K +
Sbjct: 1142 ELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK-YK 1200
Query: 4905 EGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQ- 4963
G +L++H M+E + L R+AI+ +G KC GSP +K +GDGY ++ L K +
Sbjct: 1201 PGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGY--RLTLVKRPAEP 1258
Query: 4964 ----------------------HCTVSDHLKLYFPGIQFKGQHLNLLEYHVPK---RWGC 4998
VS ++ + L Y +P + G
Sbjct: 1259 GGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGA 1318
Query: 4999 LADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTLQSTLD 5045
LF+ +E + L++ + + TTLE+VF+ + E Q S D
Sbjct: 1319 FERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEAD 1365
Score = 34.3 bits (77), Expect = 3.2
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 29 EFFWPCILFVILTVLRFQEPP-RYRDICYLQPRDLPSCGVIPFVQSLLCNTGSR 81
E F P +LF IL LR ++P +++ + L S G++P +QS LC G R
Sbjct: 58 EIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSAGILPVMQS-LCPDGQR 110
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 424 bits (1090), Expect = e-117
Identities = 268/800 (33%), Positives = 421/800 (52%), Gaps = 58/800 (7%)
Query: 3516 DGFKYNYV---FAPLQDMIERAIILVQ----TGQEALEPAAQTQAAPYPCHTSDLFLNNV 3568
DG + Y+ F +Q ++RAI+ T Q + PYP +D FL +
Sbjct: 200 DGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAI 259
Query: 3569 GFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTIS 3628
+ PL+++L++ + ++ R +V E+E +++EYMRMMG+ +H+ AWFL L I+
Sbjct: 260 QYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIA 319
Query: 3629 SA--TLAIVLKTS---GIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTS 3683
++ TL +K + + S+ +V FLL F +S + S+++S FFS+AN AA
Sbjct: 320 ASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGG 379
Query: 3684 LVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQ 3743
+Y +++PY + +N ++ + CLLS A G I E + GIQW ++
Sbjct: 380 FLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLS 439
Query: 3744 ALE-QGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFL 3802
+ FG V M+L DS LY L WY+ + PG FG+ +PWYF SYW
Sbjct: 440 PVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRA 499
Query: 3803 VEKRQYFLSSSLFFFNENFDNKGSSLQNR--EGELEGSAPGVTLVSVTKEYE-GHK--AV 3857
V ++ E + +L+N E E E G+ + ++K + G+K A
Sbjct: 500 VAGKE-----------EEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAA 548
Query: 3858 VQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMEL 3917
V+DL+L Y QIT LLG NGAGKTT +SMLTGL PPTSG I+G + D+ ++R L
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSL 608
Query: 3918 GVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALS 3977
G+CPQ DIL DNLTV EHL +A +K ++++ ++V Q L + L + ++R LS
Sbjct: 609 GLCPQHDILFDNLTVAEHLYFYAQLKG--LSRQKCPEEVKQMLHIIGLEDKWNSRSRFLS 666
Query: 3978 GGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEA 4037
GG++RKLS+GIA + S+ ++LDEPTSG+D SR ++WD+L + + RTI+ TTH +DEA
Sbjct: 667 GGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEA 726
Query: 4038 EALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKI 4097
+ L DR+A++ G L+CCG LK+ YG G +TL ++P + ++ L+
Sbjct: 727 DLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHC-------NPEDISQLVHH 779
Query: 4098 YIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLM 4157
++P A L+ S+G+EL++ +P+++ +GLF L++ +L + +G S TT+EEVFL
Sbjct: 780 HVPNATLESSAGAELSFILPRESTHR-FEGLFAKLEKKQKELGIASFGASITTMEEVFLR 838
Query: 4158 L--LQDSNKKSHIALGTESELQNHRPTGHL---SGYCGSLARPATV-------------- 4198
+ L DS+ + Q+ R S CG++ +
Sbjct: 839 VGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLN 898
Query: 4199 QGVQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRL 4258
G+ L Q A+ ++ + R K A +L+P+ V LA+ + P LRL
Sbjct: 899 TGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRL 958
Query: 4259 TPGHYQRAETYFFSSGGDNL 4278
T G Y R F G L
Sbjct: 959 TLGEYGRTVVPFSVPGTSQL 978
Score = 392 bits (1007), Expect = e-108
Identities = 243/679 (35%), Positives = 359/679 (52%), Gaps = 41/679 (6%)
Query: 4391 TLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKIL 4450
T+ +N + +HS + L ++NL+ P ++ + P KD+
Sbjct: 1036 TVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHAS---IVVSNFPQPRSALQAAKDQFN 1092
Query: 4451 ESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLF 4510
E + +AL ++ + L+++ V +R + AK +Q +SG+ +W + L+D++
Sbjct: 1093 EGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLIS 1152
Query: 4511 YLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFIS 4570
+L+ L + V AF + AFT ++A T LLL L+G+A +P MYLM+ F + A+
Sbjct: 1153 FLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTR 1212
Query: 4571 YVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELC-- 4628
N + G+ T L+ + R+ A+ L+ + L VF + P CLG +
Sbjct: 1213 LTIFNILSGIATFLMVTIMRIPAV-----KLEELSKTLDHVFLVLPNHCLGMAVSSFYEN 1267
Query: 4629 YNQIKYDLTHNFGID---SYVSPFEMNFLGW-------IFVQLASQGTVLLLLRVLLHWD 4678
Y +Y + Y ++ NF W +A+ G L+L L+ +
Sbjct: 1268 YETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETN 1327
Query: 4679 LLRWPRG-------HSTLQGTVKSS----KDTDVEKEEKRVFEGRTNGDI---LVLYNLS 4724
LL+ RG TL +D DV E R+ + + L++ LS
Sbjct: 1328 LLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELS 1387
Query: 4725 KHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPM 4784
K Y + ++AV +SL + KGECFGLLG NGAGK+TTFKML GE SLTSG A +
Sbjct: 1388 KVYEQRVP-LLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV---- 1442
Query: 4785 GDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRL 4844
G S G IGYCPQ DAL + +TG E L Y LRGIP + I + +R L
Sbjct: 1443 GGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
Query: 4845 HLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVR 4904
LE HA+K V TYSGG KRKLST +AL+G+P ++ LDEPS+GMDP ++R LW T+ +
Sbjct: 1503 LLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562
Query: 4905 EGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQH 4964
G A ++TSHSMEECEALCTRLAIMV G FKCLGSPQH+K++FG GY+++ + E Q
Sbjct: 1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQE 1622
Query: 4965 C--TVSDHLKLYFPGIQFKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQ 5022
+ L FPG + +H ++ YH+P R A +F ++E K + YS++Q
Sbjct: 1623 ALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQ 1682
Query: 5023 TTLEQVFINFASEQQQTLQ 5041
+LEQVF++FA Q T +
Sbjct: 1683 ISLEQVFLSFAHLQPPTAE 1701
Score = 191 bits (484), Expect = 2e-47
Identities = 175/656 (26%), Positives = 293/656 (44%), Gaps = 69/656 (10%)
Query: 4432 ITLYSHPYGGALLNKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHI 4491
+T+ PY + D L +I Q + L ++L F+ + +I +VV+++ K +
Sbjct: 240 VTIKRFPYPPFIA--DPFLVAI-QYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRM 296
Query: 4492 SGLGYRMYWFTNFLYDMLFYLVSVCLCVAV--IVAFQLTAFTFRKNLAATALLLSLFGYA 4549
GL ++W FL LF L++ + + A R + + L F +
Sbjct: 297 MGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAIS 356
Query: 4550 TLPWMYLMSRIFSSSDVA--------FISYVSLNFI---FGLCTMLITIMPRLLAIISKA 4598
T+ + +++S FS +++A F +Y+ F+ + T+ + LL+ ++ A
Sbjct: 357 TISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMA 416
Query: 4599 KNLQNIYDV------LKWVFTIFP-----QFCLGQGLVELCYNQIKYDLTHNFGIDSYVS 4647
Q I ++W + P FC GQ L L + + Y L + +
Sbjct: 417 MGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPG 476
Query: 4648 PFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPRGHSTLQGTVKSSKDTDVEKEEKR 4707
F + W F + S W + G K +D+D EK +
Sbjct: 477 QFGVP-QPWYFFIMPSY-----------------WCGKPRAVAG--KEEEDSDPEKALRN 516
Query: 4708 VFEGRTNGDILV---LYNLSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTF 4764
+ D++ + +LSK +R ++ AV+D++L + +G+ LLG NGAGK+TT
Sbjct: 517 EYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTL 576
Query: 4765 KMLNGEVSLTSGHAIIR--TPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYY 4822
ML G TSG A I D V + + +G CPQ D L + LT EHLY+Y
Sbjct: 577 SMLTGLFPPTSGRAYISGYEISQDMVQIRKS------LGLCPQHDILFDNLTVAEHLYFY 630
Query: 4823 CSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDE 4882
L+G+ RQ PE ++ + LE + SGG +RKLS +AL+ +L+LDE
Sbjct: 631 AQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDE 690
Query: 4883 PSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQH 4942
P+SGMD S+R +W + ++ + VLT+H M+E + L R+AIM G +C GS
Sbjct: 691 PTSGMDAISRRAIWDLLQRQ-KSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLF 749
Query: 4943 IKNRFGDGYTVKVWLCKEANQHCTVSDHLKL---YFPGIQFKGQHLNLLEYHVPKR-WGC 4998
+K ++G GY + L KE HC D +L + P + L + +P+
Sbjct: 750 LKQKYGAGY--HMTLVKE--PHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHR 805
Query: 4999 LADLFKVIENNKTFLNIKHYSINQTTLEQVFINFAS--EQQQTLQSTLDPSTDSHH 5052
LF +E + L I + + TT+E+VF+ + +Q+ P+ H
Sbjct: 806 FEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQH 861
Score = 179 bits (455), Expect = 5e-44
Identities = 107/301 (35%), Positives = 165/301 (54%), Gaps = 11/301 (3%)
Query: 3858 VQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMEL 3917
V LSL + + LLG NGAGKTT MLTG TSG + G + +D+ +VR +
Sbjct: 1399 VDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRI 1458
Query: 3918 GVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALS 3977
G CPQ D LLD++T RE L+++A ++ ++ + V TL+ + L H +K R S
Sbjct: 1459 GYCPQFDALLDHMTGREMLVMYARLRG--IPERHIGACVENTLRGLLLEPHANKLVRTYS 1516
Query: 3978 GGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTIIFTTHHLDE 4036
GG KRKLS GIA +G + LDEP++G+DP +R LWD + + RE G+ II T+H ++E
Sbjct: 1517 GGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEE 1576
Query: 4037 AEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIK 4096
EAL R+A++ G+ +C G P LK +G G L + V + + + +
Sbjct: 1577 CEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL----RAKVQSEGQQEALEEFKAFVD 1632
Query: 4097 IYIPQAFLKDSSGSELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVF 4155
+ P + L+D + Y +P +D A + G+ + E + + Y +S +LE+VF
Sbjct: 1633 LTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKE---KYGVDDYSVSQISLEQVF 1689
Query: 4156 L 4156
L
Sbjct: 1690 L 1690
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 415 bits (1066), Expect = e-115
Identities = 428/1581 (27%), Positives = 692/1581 (43%), Gaps = 244/1581 (15%)
Query: 3524 FAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVG-----FFFPLIMML 3578
F LQ I AII + T +E H+ F+ G + F I+
Sbjct: 177 FVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHS---FIGQSGVITDLYLFSCIISF 233
Query: 3579 TWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKT 3638
+ + AS+ V + +++ M MMG+ +L+W L + I + LA+V+++
Sbjct: 234 SSFIYYASVN---VTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRS 290
Query: 3639 SGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLV 3698
+ S +VF L +G+S+V L++L+S ++ L L+ + F +
Sbjct: 291 TQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTV--FWGCLGFTS 348
Query: 3699 LHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWM 3758
L+ L + L LLS AF G+ + L+ +N + G +M
Sbjct: 349 LYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLN----SNAFPHPSDGSNLIVATNFM 404
Query: 3759 ILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFN 3818
+ FD+ LY Y ++P +G R+P F +S+W +K + +
Sbjct: 405 LAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQT----QKTDHVALEDEMDAD 460
Query: 3819 ENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAVVQ---DLSLTFYRDQITALLG 3875
+F + S + E +G + + +VTKEY+G ++ DL Y QITA+LG
Sbjct: 461 PSFHD---SFEQAPPEFQGKE-AIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILG 516
Query: 3876 TNGAGKTTIISMLTGLHPPTSGTIIINGKNLQ--TDLSRVRMELGVCPQQDILLDNLTVR 3933
+GAGK+T++++L+GL PT G++ I L DL + GVCPQ ++ D LTVR
Sbjct: 517 HSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVR 576
Query: 3934 EHLLLFASIKA--PQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFM 3991
E+L LFA IK PQ KE+
Sbjct: 577 ENLRLFAKIKGILPQEVDKEIF-------------------------------------- 598
Query: 3992 GMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGR 4051
+LDEPT+G+DP SRH +W++L + + R I+F+T +DEA+ L+DR L G+
Sbjct: 599 ------LLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGK 652
Query: 4052 LRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSE 4111
L+C G LK+ +G G L+L +E + +TSL+K +IP A L S +
Sbjct: 653 LKCAGSSLFLKKKWGIGYHLSLQLNEICVEEN-------ITSLVKQHIPDAKLSAKSEGK 705
Query: 4112 LTYTIPKD-TDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSN-KKSHIA 4169
L YT+P + T+K L++ LD + L + YG+S TTL EVFL L S +S IA
Sbjct: 706 LIYTLPLERTNK--FPELYKDLD-SYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIA 762
Query: 4170 LGTESELQNHRPTGHL---SGYCGSLARPA-TVQGVQLLRAQVAAILARRLRRTLRAGKS 4225
+ E + + T L SL + T+ GV L R Q+ AI RL + K+
Sbjct: 763 ILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKA 822
Query: 4226 TLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAETYFFSSGGDNLDLTRVLL 4285
LA LL +L PL EY +++ YQ
Sbjct: 823 LLA--LLLILMAGFC-------PLLVEYTMVKI----YQ--------------------- 848
Query: 4286 RKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQDSCGCLKCPNRSASAPYLTNHLGHTL 4345
NS W P + P + P LT L +
Sbjct: 849 ------------------NSYTWELSPHLY---------FLAPGQQPHDP-LTQLL---I 877
Query: 4346 LNLSGFNMEEYLLAPSEKP-RLGGWSFGLKIPSEAGGANGNISKPPTLAKVWYNQKGFH- 4403
+N +G ++++++ + + L +FG + ++ NG I+ V N+K +
Sbjct: 878 INKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAIT-------VCCNEKNYSF 930
Query: 4404 SLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKILESIRQCGVA-LCI 4462
SL LN P +D G+ P + LE+ + + L
Sbjct: 931 SLACNAKRLNCF------PVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAY 984
Query: 4463 VLGFSILSAS----IGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLC 4518
++ + +L++S I S + D A+ ISGL YWF L D+ Y +
Sbjct: 985 IMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFL----- 1039
Query: 4519 VAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWM--YLMSRIFSSSDVAFISYVSL-- 4574
V V + F +LL++ +P Y S IF + ++FI
Sbjct: 1040 VFVFIYLMSYISNFED------MLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKN 1093
Query: 4575 NFIFGLCTMLITIMPRLLAIISKAKNLQNIYDV-LKWVFTIFPQFCLGQGLVELCYNQIK 4633
+ I+ C ++T+ S A +I++ + ++FT G + L + +
Sbjct: 1094 SGIWSFCFYVVTVF-------SVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLF 1146
Query: 4634 YDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRW----------- 4682
L +D V PF + + ++ + L L W +
Sbjct: 1147 SSLFSEERMD--VQPFLVFLIPFLHF------IIFLFTLRCLEWKFGKKSMRKDPFFRIS 1198
Query: 4683 PRGHSTLQGTVK-SSKDTDVEKEEKRVFEG--RTNGD---ILVLYNLSKHY----RRFF- 4731
PR Q + +D DV+ E R TN D +++ L K Y + F
Sbjct: 1199 PRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFS 1258
Query: 4732 --QNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVD 4789
+N IA +++S + KGE GLLG NGAGKST+ K++ G+ T+G +++
Sbjct: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG------- 1311
Query: 4790 LSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAH 4849
S G A +GYCPQ++AL LT +HL Y +++G+ + L+ L L+
Sbjct: 1312 -SGGGDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQ 1370
Query: 4850 ADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVRE-GCA 4908
PV T S G KRKL L+++G P ++LLDEPS+GMDP ++ +WQ I R
Sbjct: 1371 LKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERG 1430
Query: 4909 AVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVS 4968
A+LT+H M E EA+C R+AIMV+G +C+GS QH+K++FG Y +++ + A +
Sbjct: 1431 ALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHA 1490
Query: 4969 DHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQ 5027
+ L+L FP + ++ +L+ Y +P + LA F +E K +++ YS++Q+TLEQ
Sbjct: 1491 EILRL-FPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQ 1549
Query: 5028 VFINFASEQQ-QTLQSTLDPS 5047
VF+ + EQ+ + DPS
Sbjct: 1550 VFLELSKEQELGDFEEDFDPS 1570
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 299 bits (765), Expect = 5e-80
Identities = 239/793 (30%), Positives = 388/793 (48%), Gaps = 63/793 (7%)
Query: 3524 FAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVS 3583
F LQ I+ AII ++T + T+A T+ + ++ FP ++L ++V
Sbjct: 173 FTVLQASIDAAIIQLKTNVSLWKELESTKAVIMG-ETAVVEIDT----FPRGVILIYLVI 227
Query: 3584 VAS-----MVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKT 3638
S + +V E+E +I+E++++MG+H +L+W L +++ + S +A++
Sbjct: 228 AFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATA 287
Query: 3639 SGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYM-ISFLPYIVLL 3697
S +F S++ ++FL +G+S V + +L+ F ++ + V + F+ +++L
Sbjct: 288 SLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIIL 347
Query: 3698 VLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCW 3757
+ S V F G+ + LE G ++N L G
Sbjct: 348 IESFPKSLV--WLFSPFCHCTFVIGIAQVMHLEDFNEGASFSN----LTAGPYPLIITII 401
Query: 3758 MILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFF 3817
M+ +S Y L YL +IPG FGLR+ + SYW E+ + F
Sbjct: 402 MLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISF 461
Query: 3818 NENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKA-VVQDLSLTFYRDQITALLGT 3876
+E + S +E A ++ + T +G +++LS Y QITALLG
Sbjct: 462 SEIIEPVSSEFVGKE------AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGH 515
Query: 3877 NGAGKTTIISMLTGLHPPTSGTIIINGKNLQT--DLSRVRMELGVCPQQDILLDNLTVRE 3934
+G GK+T++++L GL PP+ G I G + ++ R +G+CPQ DI D LTV E
Sbjct: 516 SGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEE 575
Query: 3935 HLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMS 3994
+L + ASIK + Q+V + L D+D+ + Q + LSGG KRKLSLGIA +G
Sbjct: 576 NLSILASIKGIP--ANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNP 633
Query: 3995 RTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTIIFTTHHLDEAEALSDRVAVLQHGRLR 4053
+ ++LDEPT+G+DPCSRH +W+ LLKYR+ R +F+TH +DEA+ L+DR AV+ G L+
Sbjct: 634 KILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLK 692
Query: 4054 CCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVT----SLIKIYIPQAFLKDSSG 4109
C G LK +G G RL++ D C T SL+K +IP A L +
Sbjct: 693 CVGSSMFLKSKWGIGYRLSM-----------YIDKYCATESLSSLVKQHIPGATLLQQND 741
Query: 4110 SELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLML-LQDSNKKSH 4167
+L Y++P KD DK GLF ALD + L + YG+S TTLE+VFL L ++ ++
Sbjct: 742 QQLVYSLPFKDMDK--FSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKLEVEAEIDQAD 798
Query: 4168 IALGTESELQNHRPTGHLSGYCGSL-----ARPATVQGVQLLRAQVAAILARRLRRTLRA 4222
++ T+ L+ + SL + A V + L + Q+ I R
Sbjct: 799 YSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRE 858
Query: 4223 GKSTLADLLLPVLFVALAMGLFMV-RPLATEYPPLRLTPGHYQRAETYFFSSGG-DNLDL 4280
KS + LLL ++F + + +F+V P++L P + YF G +
Sbjct: 859 SKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVP------DLYFLKPGDKPHKYK 912
Query: 4281 TRVLLRKFRDQDL 4293
T +LL+ D D+
Sbjct: 913 TSLLLQNSADSDI 925
Score = 196 bits (497), Expect = 6e-49
Identities = 121/323 (37%), Positives = 180/323 (55%), Gaps = 19/323 (5%)
Query: 4735 IAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGD-AVDLSSA 4793
+A + IS + KGE GLLG NGAGKST +L G++ TSG + GD + + S
Sbjct: 1314 VATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFL----GDYSSETSED 1369
Query: 4794 GTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKP 4853
+ +GYCPQ + L T EH Y +++G+ + EV + L L+ H K
Sbjct: 1370 DDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKT 1429
Query: 4854 VATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVR-EGCAAVLT 4912
V G KRKL AL+++G P I LLDEPS+GMDP +K+++W+ I + AA+LT
Sbjct: 1430 VKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILT 1489
Query: 4913 SHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKV----WLCKEANQHCTVS 4968
+H MEE EA+C R+AIMV+G +C+G+ QH+K++FG GY +++ W+ E + +
Sbjct: 1490 THYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWI--ENLEVDRLQ 1547
Query: 4969 DHLKLYFPGIQFKGQHLNLLEYHVPKR-WGCLADLFKVIENNKTFLNIKHYSINQTTLEQ 5027
++ FP + ++L Y +PK L+ F +E K I+ YS +Q TLEQ
Sbjct: 1548 REIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQ 1607
Query: 5028 VFINFASEQQQ------TLQSTL 5044
VF+ EQ++ TL STL
Sbjct: 1608 VFVELTKEQEEEDNSCGTLNSTL 1630
Score = 177 bits (449), Expect = 2e-43
Identities = 155/606 (25%), Positives = 275/606 (45%), Gaps = 59/606 (9%)
Query: 4458 VALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFT-NFLYDMLFYLVSVC 4516
+ + +V+ FS + +V ++ K I GL +W + LY L +L+S+
Sbjct: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLL 280
Query: 4517 LCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSD----VAFISYV 4572
+ V + + + LL L+G +++ + +++ +F S V F V
Sbjct: 281 MAVIATASLLFP----QSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTV 336
Query: 4573 SLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQI 4632
+ FI GL +LI P+ L W+F+ F G+ ++ + +
Sbjct: 337 AFGFI-GLMIILIESFPKSLV----------------WLFSPFCHCTFVIGIAQVMHLE- 378
Query: 4633 KYDLTHNFGIDSYVS-PFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLL-RWPRGHSTLQ 4690
D + + P+ + + L +LL V L + + S+L
Sbjct: 379 --DFNEGASFSNLTAGPYPLIIT---IIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLY 433
Query: 4691 GTVKSSKDTDVEKEEKRVFEGRTNGDI------------------LVLYNLSKHYRRFFQ 4732
+K S + ++ + + EG NG+I + + + K YR+ +
Sbjct: 434 -FLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGE 492
Query: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSS 4792
N+ A++++S I +G+ LLG +G GKST +L G + G A I +D
Sbjct: 493 NVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEID--E 550
Query: 4793 AGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADK 4852
A +IG CPQ D ++LT E+L S++GIP I + ++ L ++ D
Sbjct: 551 MFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDN 610
Query: 4853 PVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLT 4912
SGG KRKLS +A++G P ILLLDEP++GMDPCS+ +W ++K + V +
Sbjct: 611 QAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVW-NLLKYRKANRVTVFS 669
Query: 4913 SHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLK 4972
+H M+E + L R A++ G KC+GS +K+++G GY + +++ K ++S +K
Sbjct: 670 THFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATE-SLSSLVK 728
Query: 4973 LYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFIN 5031
+ PG Q+ L Y +P K + LF ++++ L + Y ++ TTLE VF+
Sbjct: 729 QHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFLK 787
Query: 5032 FASEQQ 5037
E +
Sbjct: 788 LEVEAE 793
Score = 163 bits (412), Expect = 5e-39
Identities = 112/371 (30%), Positives = 191/371 (51%), Gaps = 31/371 (8%)
Query: 3818 NENFDNKGSSLQNREGELEG-----SAPGVTLVSVTKEYEGHK----------AVVQDLS 3862
NE+ D + + + EL G P + + ++ KEY+ K + +S
Sbjct: 1261 NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS 1320
Query: 3863 LTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRME-LGVCP 3921
+ +I LLG NGAGK+TII++L G PTSG + + + +T ++ +G CP
Sbjct: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP 1380
Query: 3922 QQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLK 3981
Q + L + T++EH ++ ++K + ++ + +++ +DL +H K + L G+K
Sbjct: 1381 QINPLWPDTTLQEHFEIYGAVKG--MSASDMKEVISRITHALDLKEHLQKTVKKLPAGIK 1438
Query: 3982 RKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDIL---LKYREGRTIIFTTHHLDEAE 4038
RKL ++ +G + +LDEP++G+DP ++ +W + K R+ R I TTH+++EAE
Sbjct: 1439 RKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAE 1497
Query: 4039 ALSDRVAVLQHGRLRCCGPPFCLKEAYGQG--LRLTLTRQPSVLEAHDLKDMACVTSLIK 4096
A+ DRVA++ G+LRC G LK +G+G L + L LE L+ I+
Sbjct: 1498 AVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQ------REIQ 1551
Query: 4097 IYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFL 4156
P A ++S S L Y IPK+ D L F L+E H + Y S TLE+VF+
Sbjct: 1552 YIFPNASRQESFSSILAYKIPKE-DVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV 1610
Query: 4157 MLLQDSNKKSH 4167
L ++ ++ +
Sbjct: 1611 ELTKEQEEEDN 1621
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 299 bits (765), Expect = 5e-80
Identities = 239/793 (30%), Positives = 388/793 (48%), Gaps = 63/793 (7%)
Query: 3524 FAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVS 3583
F LQ I+ AII ++T + T+A T+ + ++ FP ++L ++V
Sbjct: 173 FTVLQASIDAAIIQLKTNVSLWKELESTKAVIMG-ETAVVEIDT----FPRGVILIYLVI 227
Query: 3584 VAS-----MVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKT 3638
S + +V E+E +I+E++++MG+H +L+W L +++ + S +A++
Sbjct: 228 AFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATA 287
Query: 3639 SGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYM-ISFLPYIVLL 3697
S +F S++ ++FL +G+S V + +L+ F ++ + V + F+ +++L
Sbjct: 288 SLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIIL 347
Query: 3698 VLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCW 3757
+ S V F G+ + LE G ++N L G
Sbjct: 348 IESFPKSLV--WLFSPFCHCTFVIGIAQVMHLEDFNEGASFSN----LTAGPYPLIITII 401
Query: 3758 MILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFF 3817
M+ +S Y L YL +IPG FGLR+ + SYW E+ + F
Sbjct: 402 MLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISF 461
Query: 3818 NENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKA-VVQDLSLTFYRDQITALLGT 3876
+E + S +E A ++ + T +G +++LS Y QITALLG
Sbjct: 462 SEIIEPVSSEFVGKE------AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGH 515
Query: 3877 NGAGKTTIISMLTGLHPPTSGTIIINGKNLQT--DLSRVRMELGVCPQQDILLDNLTVRE 3934
+G GK+T++++L GL PP+ G I G + ++ R +G+CPQ DI D LTV E
Sbjct: 516 SGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEE 575
Query: 3935 HLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMS 3994
+L + ASIK + Q+V + L D+D+ + Q + LSGG KRKLSLGIA +G
Sbjct: 576 NLSILASIKGIP--ANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNP 633
Query: 3995 RTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTIIFTTHHLDEAEALSDRVAVLQHGRLR 4053
+ ++LDEPT+G+DPCSRH +W+ LLKYR+ R +F+TH +DEA+ L+DR AV+ G L+
Sbjct: 634 KILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLK 692
Query: 4054 CCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVT----SLIKIYIPQAFLKDSSG 4109
C G LK +G G RL++ D C T SL+K +IP A L +
Sbjct: 693 CVGSSMFLKSKWGIGYRLSM-----------YIDKYCATESLSSLVKQHIPGATLLQQND 741
Query: 4110 SELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLML-LQDSNKKSH 4167
+L Y++P KD DK GLF ALD + L + YG+S TTLE+VFL L ++ ++
Sbjct: 742 QQLVYSLPFKDMDK--FSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKLEVEAEIDQAD 798
Query: 4168 IALGTESELQNHRPTGHLSGYCGSL-----ARPATVQGVQLLRAQVAAILARRLRRTLRA 4222
++ T+ L+ + SL + A V + L + Q+ I R
Sbjct: 799 YSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRE 858
Query: 4223 GKSTLADLLLPVLFVALAMGLFMV-RPLATEYPPLRLTPGHYQRAETYFFSSGG-DNLDL 4280
KS + LLL ++F + + +F+V P++L P + YF G +
Sbjct: 859 SKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVP------DLYFLKPGDKPHKYK 912
Query: 4281 TRVLLRKFRDQDL 4293
T +LL+ D D+
Sbjct: 913 TSLLLQNSADSDI 925
Score = 196 bits (497), Expect = 6e-49
Identities = 121/323 (37%), Positives = 180/323 (55%), Gaps = 19/323 (5%)
Query: 4735 IAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGD-AVDLSSA 4793
+A + IS + KGE GLLG NGAGKST +L G++ TSG + GD + + S
Sbjct: 1314 VATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFL----GDYSSETSED 1369
Query: 4794 GTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKP 4853
+ +GYCPQ + L T EH Y +++G+ + EV + L L+ H K
Sbjct: 1370 DDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKT 1429
Query: 4854 VATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVR-EGCAAVLT 4912
V G KRKL AL+++G P I LLDEPS+GMDP +K+++W+ I + AA+LT
Sbjct: 1430 VKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILT 1489
Query: 4913 SHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKV----WLCKEANQHCTVS 4968
+H MEE EA+C R+AIMV+G +C+G+ QH+K++FG GY +++ W+ E + +
Sbjct: 1490 THYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWI--ENLEVDRLQ 1547
Query: 4969 DHLKLYFPGIQFKGQHLNLLEYHVPKR-WGCLADLFKVIENNKTFLNIKHYSINQTTLEQ 5027
++ FP + ++L Y +PK L+ F +E K I+ YS +Q TLEQ
Sbjct: 1548 REIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQ 1607
Query: 5028 VFINFASEQQQ------TLQSTL 5044
VF+ EQ++ TL STL
Sbjct: 1608 VFVELTKEQEEEDNSCGTLNSTL 1630
Score = 177 bits (449), Expect = 2e-43
Identities = 155/606 (25%), Positives = 275/606 (45%), Gaps = 59/606 (9%)
Query: 4458 VALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFT-NFLYDMLFYLVSVC 4516
+ + +V+ FS + +V ++ K I GL +W + LY L +L+S+
Sbjct: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLL 280
Query: 4517 LCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSD----VAFISYV 4572
+ V + + + LL L+G +++ + +++ +F S V F V
Sbjct: 281 MAVIATASLLFP----QSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTV 336
Query: 4573 SLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQI 4632
+ FI GL +LI P+ L W+F+ F G+ ++ + +
Sbjct: 337 AFGFI-GLMIILIESFPKSLV----------------WLFSPFCHCTFVIGIAQVMHLE- 378
Query: 4633 KYDLTHNFGIDSYVS-PFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLL-RWPRGHSTLQ 4690
D + + P+ + + L +LL V L + + S+L
Sbjct: 379 --DFNEGASFSNLTAGPYPLIIT---IIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLY 433
Query: 4691 GTVKSSKDTDVEKEEKRVFEGRTNGDI------------------LVLYNLSKHYRRFFQ 4732
+K S + ++ + + EG NG+I + + + K YR+ +
Sbjct: 434 -FLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGE 492
Query: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSS 4792
N+ A++++S I +G+ LLG +G GKST +L G + G A I +D
Sbjct: 493 NVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEID--E 550
Query: 4793 AGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADK 4852
A +IG CPQ D ++LT E+L S++GIP I + ++ L ++ D
Sbjct: 551 MFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDN 610
Query: 4853 PVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLT 4912
SGG KRKLS +A++G P ILLLDEP++GMDPCS+ +W ++K + V +
Sbjct: 611 QAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVW-NLLKYRKANRVTVFS 669
Query: 4913 SHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLK 4972
+H M+E + L R A++ G KC+GS +K+++G GY + +++ K ++S +K
Sbjct: 670 THFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATE-SLSSLVK 728
Query: 4973 LYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFIN 5031
+ PG Q+ L Y +P K + LF ++++ L + Y ++ TTLE VF+
Sbjct: 729 QHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFLK 787
Query: 5032 FASEQQ 5037
E +
Sbjct: 788 LEVEAE 793
Score = 163 bits (412), Expect = 5e-39
Identities = 112/371 (30%), Positives = 191/371 (51%), Gaps = 31/371 (8%)
Query: 3818 NENFDNKGSSLQNREGELEG-----SAPGVTLVSVTKEYEGHK----------AVVQDLS 3862
NE+ D + + + EL G P + + ++ KEY+ K + +S
Sbjct: 1261 NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS 1320
Query: 3863 LTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRME-LGVCP 3921
+ +I LLG NGAGK+TII++L G PTSG + + + +T ++ +G CP
Sbjct: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP 1380
Query: 3922 QQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLK 3981
Q + L + T++EH ++ ++K + ++ + +++ +DL +H K + L G+K
Sbjct: 1381 QINPLWPDTTLQEHFEIYGAVKG--MSASDMKEVISRITHALDLKEHLQKTVKKLPAGIK 1438
Query: 3982 RKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDIL---LKYREGRTIIFTTHHLDEAE 4038
RKL ++ +G + +LDEP++G+DP ++ +W + K R+ R I TTH+++EAE
Sbjct: 1439 RKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAE 1497
Query: 4039 ALSDRVAVLQHGRLRCCGPPFCLKEAYGQG--LRLTLTRQPSVLEAHDLKDMACVTSLIK 4096
A+ DRVA++ G+LRC G LK +G+G L + L LE L+ I+
Sbjct: 1498 AVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQ------REIQ 1551
Query: 4097 IYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFL 4156
P A ++S S L Y IPK+ D L F L+E H + Y S TLE+VF+
Sbjct: 1552 YIFPNASRQESFSSILAYKIPKE-DVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV 1610
Query: 4157 MLLQDSNKKSH 4167
L ++ ++ +
Sbjct: 1611 ELTKEQEEEDN 1621
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 274 bits (700), Expect = 2e-72
Identities = 229/789 (29%), Positives = 373/789 (47%), Gaps = 63/789 (7%)
Query: 3485 SYTIRTNVLYSVRTDVVKNPS------WKFHPQNLPADGFKYNYVFAPLQDMIERAIILV 3538
SY ++ N + R V+K S W H + + F Q I AII V
Sbjct: 45 SYRLKFN--WGYRIPVIKEHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEV 102
Query: 3539 QTGQEALEPAAQTQAA--PYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQE 3596
T +E P S + N F F ++ + + AS+ V +
Sbjct: 103 TTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLN---VARER 159
Query: 3597 IQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLD 3656
+ ++ M +MG+ +L+W L + + I S +A+V+ + I H+ ++F
Sbjct: 160 GKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSL 219
Query: 3657 FGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLST 3716
+G+S++ L++L+S + A L L + F + VL+ QL L LLS
Sbjct: 220 YGLSLIALAFLMSVLIRKPMLAGLAGFLFTV--FWGCLGFTVLYRQLPLSLGWVLSLLSP 277
Query: 3717 TAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNL 3776
AF G+ IT L+ +G+ + + + TF +++ FD+ Y + Y +
Sbjct: 278 FAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATF----FILAFDTLFYLIFTLYFERV 333
Query: 3777 IPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELE 3836
+P G F +S+W S +E F+N+ + + + E
Sbjct: 334 LPDKDGHGDSPLFFLKSSFW--------------SKHQNTHHEIFENEINPEHSSDDSFE 379
Query: 3837 GSAP------GVTLVSVTKEYEGHKAVVQDLSLTF---YRDQITALLGTNGAGKTTIISM 3887
+P + + +V KEY G V+ L F Y QITA+LG NGAGK+T++++
Sbjct: 380 PVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNI 439
Query: 3888 LTGLHPPTSGTIIINGKNLQ--TDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAP 3945
L+GL T G+ I L TD+ +R +G CPQ + D LTVRE+L +FA IK
Sbjct: 440 LSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGI 499
Query: 3946 QWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSG 4005
Q KE+ Q+V + + ++D+ Q + LSGG KRKL+LGIA +G + ++LDEPT+G
Sbjct: 500 Q--PKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAG 557
Query: 4006 VDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAY 4065
+DP SRH +W +L +++ R I+F+T +DEA+ L+DR L +G+L+C G LK +
Sbjct: 558 LDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKW 617
Query: 4066 GQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIP-KDTDKAC 4124
G G L+L R +++ D +TSLIK +IP A L S +L Y++P + T+K
Sbjct: 618 GIGYHLSLHR-------NEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNK-- 668
Query: 4125 LKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLL-QDSNKKSHIALGTESELQNHRPTG 4183
L+ LD+ Q + Y +S T+L EVFL L + + + +G + ++ R TG
Sbjct: 669 FPDLYSDLDKCSDQ-GIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTG 727
Query: 4184 HLSG----YCGSLARPATVQGVQLLRAQVAAILARRLRRTLRAGKSTLADLL-LPVLFVA 4238
S C V L R Q+ A+ R + R ++ L LL L + F+
Sbjct: 728 DESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVLGIAFIP 787
Query: 4239 LAMGLFMVR 4247
+ + M +
Sbjct: 788 IILEKIMYK 796
Score = 197 bits (501), Expect = 2e-49
Identities = 172/627 (27%), Positives = 296/627 (47%), Gaps = 61/627 (9%)
Query: 4445 NKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNF 4504
++D I+ + ++ ++L + +S IG S + D + ISGL YW
Sbjct: 922 SRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQA 981
Query: 4505 LYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSS 4564
L D+ Y + + + +I F F L L++ + G A
Sbjct: 982 LVDIPLYFL-ILFSIHLIYYFIFLGFQLSWELMFV-LVVCIIGCAV-------------- 1025
Query: 4565 DVAFISYVSLNFIF-------GLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQ 4617
+ F++YV L+FIF G + I+ ++ I + + + +L +F P
Sbjct: 1026 SLIFLTYV-LSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIF--IPS 1082
Query: 4618 FCLGQGLVELCYNQIKYDLTHNF-GIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVL-- 4674
F L G V L I+ D N +D+ ++ L + L ++R L
Sbjct: 1083 FTL-LGYVMLL---IQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEM 1138
Query: 4675 ------LHWDLLRW--PRGHSTLQGTVK-SSKDTDVEKEEKRVFEGRTNGD-----ILVL 4720
++ D + PR T + +D DV+ E + T + ++
Sbjct: 1139 KYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITA 1198
Query: 4721 YNLSKHYRRFFQNI-------IAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSL 4773
L K Y ++ IA++++S + KGE GLLG NGAGKST+ KM+ G
Sbjct: 1199 SCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP 1258
Query: 4774 TSGHAIIRTPMGDAVDLSSAGTAGV-LIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQC 4832
T+G +++ G + + +GYCPQ+++L LT EHL Y +++G+ ++
Sbjct: 1259 TAGVVVLQ---GSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKED 1315
Query: 4833 IPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSK 4892
L+ L L+ PV T S G KRKL L+++G P ++LLDEP +GMDP +
Sbjct: 1316 AALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQ 1375
Query: 4893 RYLWQTIMKEVR-EGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGY 4951
+ +WQ + V+ + +LT+H M E EA+C R+A+MV+G+ +C+GS QH+KN+FG Y
Sbjct: 1376 QQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDY 1435
Query: 4952 TVKVWLCKEANQHCTVSDHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNK 5010
+++ + + ++ LKL FP ++ ++ +L+ Y +P + L+ F +E K
Sbjct: 1436 LLEIKMKEPTQVEALHTEILKL-FPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMK 1494
Query: 5011 TFLNIKHYSINQTTLEQVFINFASEQQ 5037
N++ YS++Q TLEQVF+ EQ+
Sbjct: 1495 QTFNLEEYSLSQATLEQVFLELCKEQE 1521
Score = 159 bits (402), Expect = 7e-38
Identities = 101/313 (32%), Positives = 175/313 (55%), Gaps = 18/313 (5%)
Query: 3855 KAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGK--NLQTDLSR 3912
K ++++S + ++ LLG NGAGK+T I M+TG PT+G +++ G +++
Sbjct: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDN 1278
Query: 3913 VRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQ 3972
LG CPQ++ L LT++EHL L+A++K K++ +++ ++ + L +
Sbjct: 1279 SLKFLGYCPQENSLWPKLTMKEHLELYAAVKG--LGKEDAALSISRLVEALKLQEQLKAP 1336
Query: 3973 TRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDIL---LKYREGRTIIF 4029
+ LS G+KRKL ++ +G V+LDEP +G+DP + +W IL +K +E T++
Sbjct: 1337 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLL- 1395
Query: 4030 TTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTL-TRQPSVLEAHDLKDM 4088
TTH++ EAEA+ DR+A++ G LRC G LK +G+ L + ++P+ +E
Sbjct: 1396 TTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVE------- 1448
Query: 4089 ACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISD 4148
A T ++K++ PQA ++ S + Y +P + D L F L+ +L Y +S
Sbjct: 1449 ALHTEILKLF-PQAAWQERYSSLMAYKLPVE-DVHPLSRAFFKLEAMKQTFNLEEYSLSQ 1506
Query: 4149 TTLEEVFLMLLQD 4161
TLE+VFL L ++
Sbjct: 1507 ATLEQVFLELCKE 1519
Score = 147 bits (372), Expect = 2e-34
Identities = 136/572 (23%), Positives = 250/572 (43%), Gaps = 60/572 (10%)
Query: 4486 KRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSL 4545
K+L + GL +W + L + F + VI + + F L SL
Sbjct: 163 KKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITSIPIV---FHTGFMVIFTLYSL 219
Query: 4546 FGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIY 4605
+G + + +LMS + +A ++ +G + T++ R L +
Sbjct: 220 YGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGC--LGFTVLYRQLPLS---------- 267
Query: 4606 DVLKWVFTIFPQFCLGQGLVELCY--NQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLAS 4663
L WV ++ F G+ ++ + N + + + DSY + F+ +
Sbjct: 268 --LGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSY------KMIATFFI--LA 317
Query: 4664 QGTVLLLLRVLLHWDLLRWPRGHSTLQ-GTVKSSKDTDVEKEEKRVFEGRTNGD------ 4716
T+ L+ L +L GH +KSS + + +FE N +
Sbjct: 318 FDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSDDS 377
Query: 4717 ------------ILVLYNLSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTF 4764
+ + N+ K Y + A+Q I I +G+ +LG NGAGKST
Sbjct: 378 FEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLL 437
Query: 4765 KMLNGEVSLTSGHAII-RTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYC 4823
+L+G T G A I T + + D+ IG+CPQ + + LT E+L +
Sbjct: 438 NILSGLSVSTEGSATIYNTQLSEITDMEEIRKN---IGFCPQFNFQFDFLTVRENLRVFA 494
Query: 4824 SLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEP 4883
++GI + + + +I L +++ D SGG KRKL+ +A++G P +LLLDEP
Sbjct: 495 KIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEP 554
Query: 4884 SSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHI 4943
++G+DP S+ +W +++KE + + ++ M+E + L R + NG KC GS +
Sbjct: 555 TAGLDPFSRHRVW-SLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFL 613
Query: 4944 KNRFGDGYTVKVWLCKEANQHC---TVSDHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCL 4999
K ++G GY + + N+ C ++ +K + P + + L Y +P ++
Sbjct: 614 KRKWGIGYHLSL----HRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKF 669
Query: 5000 ADLFKVIENNKTFLNIKHYSINQTTLEQVFIN 5031
DL+ ++ I++Y+++ T+L +VF+N
Sbjct: 670 PDLYSDLDKCSD-QGIRNYAVSVTSLNEVFLN 700
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 261 bits (666), Expect = 2e-68
Identities = 225/783 (28%), Positives = 365/783 (46%), Gaps = 63/783 (8%)
Query: 3524 FAPLQDMIERAIILVQTGQEALEP-----AAQTQAAPYPCH---TSDLFLNNVGFFFPLI 3575
F Q I AII + T +E + P+ +D F+ FF +I
Sbjct: 178 FVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFI-----FFCII 232
Query: 3576 MMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIV 3635
T++ V+ V ++ I M MMG+ +L+W L + I + +A++
Sbjct: 233 SFSTFIYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALI 288
Query: 3636 LKTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIV 3695
+K++ I + +VF L +G+S++ L++L+S + L L +I F +
Sbjct: 289 VKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFL--LIVFWGILG 346
Query: 3696 LLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWV 3755
L+ +L + LCLLS AF G+ + L+ +N + Q
Sbjct: 347 FPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVN----SNAHLDSSQNPYLIIAT 402
Query: 3756 CWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLF 3815
+M++FD+ LY + Y ++P +G R F + +W G + S
Sbjct: 403 LFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDP 462
Query: 3816 FFNENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAVVQDLS---LTFYRDQITA 3872
N+ F+ +E + + ++ KEY G V+ L Y QITA
Sbjct: 463 TPNDCFEPVSPEFCGKEA--------IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITA 514
Query: 3873 LLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQ--TDLSRVRMELGVCPQQDILLDNL 3930
LLG +GAGKTT++++L+GL PTSG++ + L D+ + G CPQ ++ L
Sbjct: 515 LLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFL 574
Query: 3931 TVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAF 3990
TV+E+L LFA IK E+ ++V + +Q++++ Q + LSGG RKL+ GIA
Sbjct: 575 TVKENLRLFAKIKGI--LPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAI 632
Query: 3991 MGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHG 4050
+G + ++LDEPT+G+DP SRH +W++L + + R I+F+T +DEA+ L+DR + +G
Sbjct: 633 LGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNG 692
Query: 4051 RLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGS 4110
+L+C G LK+ +G G L+ L ++ D +TSL+K +I A L S
Sbjct: 693 KLKCAGSSLFLKKKWGIGYHLS-------LHLNERCDPESITSLVKQHISDAKLTAQSEE 745
Query: 4111 ELTYTIPKD-TDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSN-KKSHI 4168
+L Y +P + T+K L++ LD +Q + YG+S TTL EVFL L S +S I
Sbjct: 746 KLVYILPLERTNK--FPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGKSTIDESDI 802
Query: 4169 ALGTESELQNHRPTGHLSGYCGSLA----RPATVQGVQLLRAQVAAILARRLRRTLRAGK 4224
+ + + + G L L+ T+ GV L R QV AI R + + K
Sbjct: 803 GIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERK 862
Query: 4225 STLADLLL-PVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAETYFFSSGGDNLD-LTR 4282
S LLL + F+ + Y P L+P TYF S G D LT
Sbjct: 863 SLWTILLLFGISFIPQLLEHLFYESYQKSY-PWELSP------NTYFLSPGQQPQDPLTH 915
Query: 4283 VLL 4285
+L+
Sbjct: 916 LLV 918
Score = 205 bits (522), Expect = 8e-52
Identities = 175/613 (28%), Positives = 282/613 (46%), Gaps = 77/613 (12%)
Query: 4473 IGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTF 4532
I S + D A ISGL YWF L D+ Y + + L + F F
Sbjct: 1040 IAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFSPEEIIF 1099
Query: 4533 RKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTMLITIMPRLL 4592
+L S+ GY S + F++YV ++FIF
Sbjct: 1100 IIQNLLIQILCSI-GYV--------------SSLVFLTYV-ISFIF-------------- 1129
Query: 4593 AIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQI---KYDLTHNFGIDSYVSPF 4649
K + + + ++ +F+I G + L + + + L + I S +SP
Sbjct: 1130 RNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPD 1189
Query: 4650 EMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRW-------------------PRGHSTLQ 4690
M++LG ++ ++ L L+ +LR PR ++
Sbjct: 1190 SMDYLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFP 1249
Query: 4691 GTVK-SSKDTDVEKEEKRVFEGRTNGD-----ILVLYNLSKHYRRFFQNI-------IAV 4737
+ ++ D++ E R D +++ L K Y +N IA
Sbjct: 1250 NPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIAT 1309
Query: 4738 QDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAG 4797
+++S + KGE GLLG NGAGKSTT KM+ G+ T+G I++ S G
Sbjct: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG--------SGGGEPL 1361
Query: 4798 VLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATY 4857
+GYCPQ++AL LT +HL Y +++G+ + L+ L L+ PV T
Sbjct: 1362 GFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTL 1421
Query: 4858 SGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVRE-GCAAVLTSHSM 4916
S G KRKL L+++G P ++LLDEPS+GMDP ++ +WQ I R A+LT+H M
Sbjct: 1422 SEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYM 1481
Query: 4917 EECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFP 4976
E EA+C R+AIMV+G +C+GS QH+K++FG Y +++ L A ++ L+L FP
Sbjct: 1482 AEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRL-FP 1540
Query: 4977 GIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASE 5035
+ + +L+ Y +P + L+ F +E K +++ YS++Q+TLEQVF+ + E
Sbjct: 1541 QAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKE 1600
Query: 5036 QQ-QTLQSTLDPS 5047
Q+ L+ DPS
Sbjct: 1601 QELGDLEEDFDPS 1613
Score = 156 bits (394), Expect = 6e-37
Identities = 151/632 (23%), Positives = 273/632 (43%), Gaps = 74/632 (11%)
Query: 4448 KILESIRQCGVALCIVLGFSILSAS-----IGSSVVRDRVIGAKRLQHISGLGYRMYWFT 4502
KIL + Q GVA + F I+S S + +V ++R L + GL +W +
Sbjct: 211 KILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQY-ITSLMTMMGLRESAFWLS 269
Query: 4503 NFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFS 4562
L F L+ L ++ + Q+ T L L+G + + +LMS +
Sbjct: 270 WGLMYAGFILIMATLMALIVKSAQIVVLT---GFVMVFTLFLLYGLSLITLAFLMSVLIK 326
Query: 4563 SSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQ 4622
F+ GL L+ + +L + L L+W + F
Sbjct: 327 KP-----------FLTGLVVFLLIVFWGILGFPALYTRLPAF---LEWTLCLLSPFAFTV 372
Query: 4623 GLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRW 4682
G+ +L + + YD+ N +DS +P+ + + +F+ + T+L L+ L +L
Sbjct: 373 GMAQLIH--LDYDVNSNAHLDSSQNPYLI--IATLFMLVFD--TLLYLVLTLYFDKILPA 426
Query: 4683 PRGHSTLQ---------------GTVKSSKDTDVEKEEKRVFEGRT----NGDILVLYNL 4723
GH V +TD + FE + + + + NL
Sbjct: 427 EYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNL 486
Query: 4724 SKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIR-- 4781
K Y + + A++ + I +G+ LLG +GAGK+T +L+G TSG +
Sbjct: 487 KKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNH 546
Query: 4782 --TPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGD 4839
+ M D ++S G+CPQ + LT E+L + ++GI + +
Sbjct: 547 TLSRMADIENISK------FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR 600
Query: 4840 LIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTI 4899
+++ L +E D SGG RKL+ +A++G P +LLLDEP++G+DP S+ +W +
Sbjct: 601 VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIW-NL 659
Query: 4900 MKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCK 4959
+KE + + ++ ++E + L R + NG KC GS +K ++G GY + + L
Sbjct: 660 LKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHL-- 717
Query: 4960 EANQHC---TVSDHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNI 5015
N+ C +++ +K + + Q L Y +P +R +L++ ++ I
Sbjct: 718 --NERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSN-QGI 774
Query: 5016 KHYSINQTTLEQVFINFASEQQQTLQSTLDPS 5047
+ Y ++ TTL +VF+ +ST+D S
Sbjct: 775 EDYGVSITTLNEVFLKLEG------KSTIDES 800
Score = 156 bits (394), Expect = 6e-37
Identities = 156/622 (25%), Positives = 275/622 (44%), Gaps = 67/622 (10%)
Query: 3564 FLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMA 3623
+ +N F+ P+ T ++++S + + + + +R+ G++P ++ L +++
Sbjct: 1022 YRSNTFFWIPMAASFTPYIAMSS-----IGDYKKKAHSQLRISGLYPSAYWFGQALVDVS 1076
Query: 3624 ----VLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAA 3679
+L + I IF N I L + + S+V L+Y++S F +
Sbjct: 1077 LYFLILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNS 1136
Query: 3680 LCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWN 3739
S ++I + IV L N+ F+ F +L G FI F E
Sbjct: 1137 GIWSFFFLIVVIFSIVATDL-NEYGFLGLFFGTMLIPPFTLIGSLFI-FSEISP------ 1188
Query: 3740 NMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSV 3799
+++ G + + ++ L L+FL ++ + RK K
Sbjct: 1189 ---DSMDYLGASESEIVYLALLIPYLHFLIFLFILRCLE--MNCRKKLMR-------KDP 1236
Query: 3800 GFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGS--------APGVTLVSVTKEY 3851
F + R S+++F E + + +Q + P + + KEY
Sbjct: 1237 VFRISPR----SNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEY 1292
Query: 3852 EGHKA----------VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIII 3901
G K +++S + ++ LLG NGAGK+T I M+TG PT+G +I+
Sbjct: 1293 AGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVIL 1352
Query: 3902 NGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQ 3961
G L LG CPQ++ L NLTVR+HL ++A++K + K + + + +
Sbjct: 1353 KGSGGGEPLGF----LGYCPQENALWPNLTVRQHLEVYAAVKGLR--KGDAMIAITRLVD 1406
Query: 3962 DVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDIL-LK 4020
+ L + LS G+KRKL ++ +G V+LDEP++G+DP + +W ++
Sbjct: 1407 ALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRAT 1466
Query: 4021 YREG-RTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSV 4079
+R R + TTH++ EAEA+ DRVA++ GRLRC G LK +G+ L
Sbjct: 1467 FRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLE------- 1519
Query: 4080 LEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQL 4139
++ +L M + + I PQA ++ S + Y +P + D L F L+
Sbjct: 1520 MKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVE-DVRPLSQAFFKLEIVKQSF 1578
Query: 4140 HLTGYGISDTTLEEVFLMLLQD 4161
L Y +S +TLE+VFL L ++
Sbjct: 1579 DLEEYSLSQSTLEQVFLELSKE 1600
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 259 bits (663), Expect = 4e-68
Identities = 217/743 (29%), Positives = 347/743 (46%), Gaps = 82/743 (11%)
Query: 3520 YNYVFAPLQDMIERAIILVQTGQEALEPAAQTQAAPY---PCHTSDLFLNNVGFFFPLIM 3576
+N F LQ I AII + T +E A P T +L N + F L+
Sbjct: 171 WNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLH 230
Query: 3577 MLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVL 3636
+ ++ V K + + + M+MMG+ +L+W L + I S + I++
Sbjct: 231 FSPLVYFISLNVTK----ERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIII 286
Query: 3637 KTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMIS-FLPYIV 3695
+ I + ++F+ +G+S+V L +L+S +A L +V++++ F +
Sbjct: 287 TFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKA---VLTNLVVFLLTLFWGCLG 343
Query: 3696 LLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWV 3755
V + QL + L + S AF G+ I L+ G+ + + TF
Sbjct: 344 FTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFS-- 401
Query: 3756 CWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLF 3815
M+L D +Y L Y ++P +G ++R Y S LF
Sbjct: 402 --MLLLDGLIYLLLALYFDKILP--YG---------------------DERHY---SPLF 433
Query: 3816 FFNEN--FDNKGSSLQNREGELEGSAPG----------------VTLVSVTKEYEGHKAV 3857
F N + F ++ ++ + E E++ P + + +V KEY+G
Sbjct: 434 FLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGK 493
Query: 3858 VQDLS---LTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQT--DLSR 3912
V+ L Y QITA+LG +GAGK++++++L GL PT G++ I KNL DL
Sbjct: 494 VEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEE 553
Query: 3913 VRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQ 3972
+R GVCPQ ++ D LTV+E+L LFA IK KE+ Q+V + L ++D+ Q
Sbjct: 554 IRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHL--KEVEQEVQRILLELDMQNIQDNL 611
Query: 3973 TRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTH 4032
+ LS G KRKL+ GI +G + ++LDEPT+G+DP SR +W +L + R I+F+T
Sbjct: 612 AKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQ 671
Query: 4033 HLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVT 4092
+DEA+ L+DR ++ +GRL+C G LK +G G L+L R +++ + +T
Sbjct: 672 SMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHR-------NEICNPEQIT 724
Query: 4093 SLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLE 4152
S I +IP A LK + +L YT+P + LF LD+ Q +TGY IS +TL
Sbjct: 725 SFITHHIPDAKLKTENKEKLVYTLPLERTNT-FPDLFSDLDKCSDQ-GVTGYDISMSTLN 782
Query: 4153 EVFLMLLQDSNKK---SHIALGTESELQNHRPTGHLSGYCGSLARPATVQGVQLLRAQVA 4209
EVF+ L S + + + +SE N H S V + L R QV
Sbjct: 783 EVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSS----FSEMQTAVSDMGLWRMQVF 838
Query: 4210 AILARRLRRTLRAGKSTLADLLL 4232
A+ R + R K L LL+
Sbjct: 839 AMARLRFLKLKRQTKVLLTLLLV 861
Score = 184 bits (466), Expect = 3e-45
Identities = 109/305 (35%), Positives = 172/305 (56%), Gaps = 13/305 (4%)
Query: 4735 IAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAG 4794
IA ++IS + +GE GLLG NGAGKS++ +M++G T+G V+L
Sbjct: 1301 IAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGE----------VELKGCS 1350
Query: 4795 TAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPV 4854
+ +GYCPQ++ L +LT EHL Y +++G+ + L+ L + PV
Sbjct: 1351 SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPV 1410
Query: 4855 ATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAV-LTS 4913
+ G RKL L+L+G +LLLDEPS+G+DP ++ +WQ I V+ V LT+
Sbjct: 1411 QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTT 1470
Query: 4914 HSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKL 4973
H++ E EALC R+AIMV+G +C+GS QH+KN+ G Y +++ + KE +Q V +
Sbjct: 1471 HNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKV-KETSQVTLVHTEILK 1529
Query: 4974 YFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINF 5032
FP + ++ +LL Y +P L+ F +E K N++ YS++Q TLE+VF+
Sbjct: 1530 LFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLEL 1589
Query: 5033 ASEQQ 5037
+ EQ+
Sbjct: 1590 SKEQE 1594
Score = 168 bits (425), Expect = 1e-40
Identities = 155/570 (27%), Positives = 264/570 (46%), Gaps = 70/570 (12%)
Query: 3611 VIHFLAWFLENMAVLTISSATL-AIVLKTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLS 3669
++ +L +++ENM L I+S + A+V+ T G A + + F++++ F
Sbjct: 1074 LLMYLIFYIENMQYLLITSQIVFALVIVTPGYAA---SLVFFIYMISF------------ 1118
Query: 3670 AFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFL 3729
F + + L + + S + + + L+ H LS + T + + S T G F TFL
Sbjct: 1119 IFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLG----FKTFL 1174
Query: 3730 EGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYF 3789
E ++ + +A + T VC++ F + L F+ L G +RK F
Sbjct: 1175 EVRDQE-HYREFPEANFELSATDFLVCFIPYFQT-LLFVFVLRCMELKCGKKRMRKDPVF 1232
Query: 3790 PFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREG---ELEGSAPGVTLVS 3846
+ + E +E+ D + ++ + P +
Sbjct: 1233 RISPQSRDAKPNPEEP-----------IDEDEDIQTERIRTATALTTSILDEKPVIIASC 1281
Query: 3847 VTKEYEGHKA----------VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTS 3896
+ KEY G K +++S +I LLG NGAGK++ I M++G+ PT+
Sbjct: 1282 LHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTA 1341
Query: 3897 GTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQV 3956
G + + G S V LG CPQ+++L LT+REHL ++A++K + K + +
Sbjct: 1342 GEVELKG------CSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLR--KADARLAI 1393
Query: 3957 NQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWD 4016
+ + L + + + L+ G+ RKL ++ +G S ++LDEP++G+DP + +W
Sbjct: 1394 ARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQ 1453
Query: 4017 IL---LKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQG--LRL 4071
+ +K E R ++ TTH+L EAEAL DRVA++ GRLRC G LK G+ L L
Sbjct: 1454 AIQAVVKNTE-RGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILEL 1512
Query: 4072 TLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQA 4131
+ V H T ++K++ PQA ++ S LTY +P D L F
Sbjct: 1513 KVKETSQVTLVH--------TEILKLF-PQAAGQERYSSLLTYKLPV-ADVYPLSQTFHK 1562
Query: 4132 LDENLHQLHLTGYGISDTTLEEVFLMLLQD 4161
L+ H +L Y +S TLE+VFL L ++
Sbjct: 1563 LEAVKHNFNLEEYSLSQCTLEKVFLELSKE 1592
Score = 156 bits (395), Expect = 4e-37
Identities = 164/678 (24%), Positives = 294/678 (43%), Gaps = 67/678 (9%)
Query: 4391 TLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKIL 4450
TL K W +GF +L + +N I H IT+ + P+ + K+ +
Sbjct: 166 TLTKYW--NRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPF----ITKNLLH 219
Query: 4451 ESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFT-NFLYDML 4509
+ L +L FS L I +V ++R +K L + GL +W + +Y
Sbjct: 220 NEM----FILFFLLHFSPLVYFISLNVTKERK-KSKNLMKMMGLQDSAFWLSWGLIYAGF 274
Query: 4510 FYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFI 4569
+++S+ V +I+ F T +L L+G + + ++LMS + + + +
Sbjct: 275 IFIISIF--VTIIITF--TQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNL 330
Query: 4570 SYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCY 4629
L +G + + + L+W+ I F G++++
Sbjct: 331 VVFLLTLFWGCLGFTVFY--------------EQLPSSLEWILNICSPFAFTTGMIQI-- 374
Query: 4630 NQIKYDLTHNFGI------DSY--VSPFEMNFL-GWIFVQLASQGTVLLLLRVLLHWDLL 4680
IK D N I DSY ++ F M L G I++ LA +L H+ L
Sbjct: 375 --IKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPL 432
Query: 4681 RWPRGHSTLQGTVKSSK----DTDVEKEEKRVFEGRT----NGDILVLYNLSKHYRRFFQ 4732
+ S Q ++K + D E FE + + + N+ K Y+
Sbjct: 433 FFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSG 492
Query: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTP-MGDAVDLS 4791
+ A++ + I +G+ +LG +GAGKS+ +LNG T G I + + DL
Sbjct: 493 KVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLE 552
Query: 4792 SAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHAD 4851
+ G CPQ + ++LT E+L + ++GI + + + ++ L ++ D
Sbjct: 553 EIRK---ITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQD 609
Query: 4852 KPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
S G KRKL+ + ++G P ILLLDEP++G+DP S+ +W ++++E R +
Sbjct: 610 NLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVW-SLLRERRADHVILF 668
Query: 4912 TSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCT---VS 4968
++ SM+E + L R IM NG KC GS +K R+G GY + + N+ C ++
Sbjct: 669 STQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSL----HRNEICNPEQIT 724
Query: 4969 DHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQ 5027
+ + P + K ++ L Y +P +R DLF ++ + Y I+ +TL +
Sbjct: 725 SFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSD-QGVTGYDISMSTLNE 783
Query: 5028 VFINFASEQQQTLQSTLD 5045
VF+ E Q T++ +
Sbjct: 784 VFMKL--EGQSTIEQDFE 799
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 148 bits (373), Expect = 2e-34
Identities = 71/143 (49%), Positives = 96/143 (67%)
Query: 4813 LTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALV 4872
+T E + Y + G+ I + L LE+HA + + TYS G KR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 4873 GKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNG 4932
G+ ++ LDEPS+GMDP ++R LW + K G A V+TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 4933 SFKCLGSPQHIKNRFGDGYTVKV 4955
F CLGSPQH+K++FG+ Y +KV
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
Score = 94.7 bits (234), Expect = 2e-18
Identities = 49/140 (35%), Positives = 83/140 (59%), Gaps = 7/140 (5%)
Query: 3930 LTVREHLLLFASIKAPQW--TKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLG 3987
+T +E ++++A I W ++ ++ VN+ L ++L H + S G KR+LS
Sbjct: 1 MTAQEIMIMYARI----WGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTA 56
Query: 3988 IAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTIIFTTHHLDEAEALSDRVAV 4046
IA MG S + LDEP++G+DP +R LW+++ K RE G+ I+ T+H ++E +AL +A+
Sbjct: 57 IALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAI 116
Query: 4047 LQHGRLRCCGPPFCLKEAYG 4066
+ G+ C G P LK +G
Sbjct: 117 MVQGKFTCLGSPQHLKSKFG 136
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 148 bits (373), Expect = 2e-34
Identities = 71/143 (49%), Positives = 96/143 (67%)
Query: 4813 LTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALV 4872
+T E + Y + G+ I + L LE+HA + + TYS G KR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 4873 GKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNG 4932
G+ ++ LDEPS+GMDP ++R LW + K G A V+TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 4933 SFKCLGSPQHIKNRFGDGYTVKV 4955
F CLGSPQH+K++FG+ Y +KV
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
Score = 94.7 bits (234), Expect = 2e-18
Identities = 49/140 (35%), Positives = 83/140 (59%), Gaps = 7/140 (5%)
Query: 3930 LTVREHLLLFASIKAPQW--TKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLG 3987
+T +E ++++A I W ++ ++ VN+ L ++L H + S G KR+LS
Sbjct: 1 MTAQEIMIMYARI----WGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTA 56
Query: 3988 IAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTIIFTTHHLDEAEALSDRVAV 4046
IA MG S + LDEP++G+DP +R LW+++ K RE G+ I+ T+H ++E +AL +A+
Sbjct: 57 IALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAI 116
Query: 4047 LQHGRLRCCGPPFCLKEAYG 4066
+ G+ C G P LK +G
Sbjct: 117 MVQGKFTCLGSPQHLKSKFG 136
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 148 bits (373), Expect = 2e-34
Identities = 71/143 (49%), Positives = 96/143 (67%)
Query: 4813 LTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALV 4872
+T E + Y + G+ I + L LE+HA + + TYS G KR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 4873 GKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNG 4932
G+ ++ LDEPS+GMDP ++R LW + K G A V+TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 4933 SFKCLGSPQHIKNRFGDGYTVKV 4955
F CLGSPQH+K++FG+ Y +KV
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
Score = 94.7 bits (234), Expect = 2e-18
Identities = 49/140 (35%), Positives = 83/140 (59%), Gaps = 7/140 (5%)
Query: 3930 LTVREHLLLFASIKAPQW--TKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLG 3987
+T +E ++++A I W ++ ++ VN+ L ++L H + S G KR+LS
Sbjct: 1 MTAQEIMIMYARI----WGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTA 56
Query: 3988 IAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTIIFTTHHLDEAEALSDRVAV 4046
IA MG S + LDEP++G+DP +R LW+++ K RE G+ I+ T+H ++E +AL +A+
Sbjct: 57 IALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAI 116
Query: 4047 LQHGRLRCCGPPFCLKEAYG 4066
+ G+ C G P LK +G
Sbjct: 117 MVQGKFTCLGSPQHLKSKFG 136
>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 88.6 bits (218), Expect = 1e-16
Identities = 63/204 (30%), Positives = 109/204 (53%), Gaps = 10/204 (4%)
Query: 3853 GHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDLS 3911
G+K +++ LS F R ++ ++G +GAGK+T +++L G G I++NG+ +L
Sbjct: 80 GYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGR--PRELR 137
Query: 3912 RVRMELGVCPQQDILLDNLTVREHLLLFASIKAP--QWTKKELHQQVNQTLQDVDLTQHQ 3969
R Q D+LL +LTV E +++ A++K Q KKEL V + L + L
Sbjct: 138 TFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL---VTEILTALGLMSCS 194
Query: 3970 HKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTII 4028
H +T LSGG +++L++ + + + DEPTSG+D S + ++ + GRTII
Sbjct: 195 HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTII 254
Query: 4029 FTTHHLD-EAEALSDRVAVLQHGR 4051
T H + + D++ +L G+
Sbjct: 255 CTIHQPSAKLFEMFDKLYILSQGQ 278
Score = 56.6 bits (135), Expect = 6e-07
Identities = 48/166 (28%), Positives = 82/166 (49%), Gaps = 9/166 (5%)
Query: 4748 ECFGLLGVNGAGKSTTFKMLNG-EVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQ 4806
E G++G +GAGKST +L G S G ++ G +L T + Y Q
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVN---GRPRELR---TFRKMSCYIMQD 149
Query: 4807 DALDELLTGWEHLYYYCSLRGIPRQCIP-EVAGDLIRRLHLEAHADKPVATYSGGTKRKL 4865
D L LT E + +L+ +Q + E+ +++ L L + + A SGG +++L
Sbjct: 150 DMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRL 209
Query: 4866 STALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
+ AL LV P ++ DEP+SG+D S + ++MK + +G ++
Sbjct: 210 AIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKSLAQGGRTII 254
>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 88.6 bits (218), Expect = 1e-16
Identities = 63/204 (30%), Positives = 109/204 (53%), Gaps = 10/204 (4%)
Query: 3853 GHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDLS 3911
G+K +++ LS F R ++ ++G +GAGK+T +++L G G I++NG+ +L
Sbjct: 80 GYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGR--PRELR 137
Query: 3912 RVRMELGVCPQQDILLDNLTVREHLLLFASIKAP--QWTKKELHQQVNQTLQDVDLTQHQ 3969
R Q D+LL +LTV E +++ A++K Q KKEL V + L + L
Sbjct: 138 TFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL---VTEILTALGLMSCS 194
Query: 3970 HKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTII 4028
H +T LSGG +++L++ + + + DEPTSG+D S + ++ + GRTII
Sbjct: 195 HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTII 254
Query: 4029 FTTHHLD-EAEALSDRVAVLQHGR 4051
T H + + D++ +L G+
Sbjct: 255 CTIHQPSAKLFEMFDKLYILSQGQ 278
Score = 56.6 bits (135), Expect = 6e-07
Identities = 48/166 (28%), Positives = 82/166 (49%), Gaps = 9/166 (5%)
Query: 4748 ECFGLLGVNGAGKSTTFKMLNG-EVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQ 4806
E G++G +GAGKST +L G S G ++ G +L T + Y Q
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVN---GRPRELR---TFRKMSCYIMQD 149
Query: 4807 DALDELLTGWEHLYYYCSLRGIPRQCIP-EVAGDLIRRLHLEAHADKPVATYSGGTKRKL 4865
D L LT E + +L+ +Q + E+ +++ L L + + A SGG +++L
Sbjct: 150 DMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRL 209
Query: 4866 STALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
+ AL LV P ++ DEP+SG+D S + ++MK + +G ++
Sbjct: 210 AIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKSLAQGGRTII 254
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 88.2 bits (217), Expect = 2e-16
Identities = 59/203 (29%), Positives = 111/203 (54%), Gaps = 8/203 (3%)
Query: 3857 VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNL-QTDLSRVRM 3915
V+Q LSL + Q AL+G++G GK+T++ +L + P +G ++++GK + + ++ +R
Sbjct: 1052 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRA 1111
Query: 3916 ELGVCPQQDILLD-----NLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
LG+ Q+ IL D N+ ++ + + + + K+ ++L + T+
Sbjct: 1112 HLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGD 1171
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
K T+ LSGG K+++++ A + ++LDE TS +D S + + L K REGRT I
Sbjct: 1172 KGTQ-LSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVI 1230
Query: 4031 THHLDEAEALSDRVAVLQHGRLR 4053
H L + +D + V Q+GR++
Sbjct: 1231 AHRLSTIQN-ADLIVVFQNGRVK 1252
Score = 70.1 bits (170), Expect = 5e-11
Identities = 59/226 (26%), Positives = 108/226 (47%), Gaps = 22/226 (9%)
Query: 3819 ENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAV--VQDLSLTFYRDQITALLGT 3876
+++ G N +G LE +V Y K V ++ L+L Q AL+G
Sbjct: 376 DSYSKSGHKPDNIKGNLE-------FRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGN 428
Query: 3877 NGAGKTTIISMLTGLHPPTSGTIIINGKNLQT-DLSRVRMELGVCPQQDILLDNLTVREH 3935
+G GK+T + ++ L+ PT G + ++G++++T ++ +R +GV Q+ +L T+ E+
Sbjct: 429 SGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFAT-TIAEN 487
Query: 3936 LLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHK-------QTRALSGGLKRKLSLGI 3988
+ T E+ + V + + + HK + LSGG K+++++
Sbjct: 488 I----RYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIAR 543
Query: 3989 AFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHL 4034
A + + ++LDE TS +D S + L K R+GRT I H L
Sbjct: 544 ALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRL 589
Score = 61.2 bits (147), Expect = 2e-08
Identities = 54/218 (24%), Positives = 102/218 (46%), Gaps = 13/218 (5%)
Query: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSS 4792
+I +Q +SL + KG+ L+G +G GKST ++L +G ++ G + +
Sbjct: 1049 DIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLD---GKEIKRLN 1105
Query: 4793 AGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADK 4852
+G Q+ L + E++ Y + R + ++ I A + +E+ +K
Sbjct: 1106 VQWLRAHLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNK 1164
Query: 4853 -------PVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVRE 4905
SGG K++++ A ALV +P ILLLDE +S +D S++ + Q + + RE
Sbjct: 1165 YSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVV-QEALDKARE 1223
Query: 4906 GCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHI 4943
G ++ +H + + + + NG K G+ Q +
Sbjct: 1224 GRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1260
Score = 52.4 bits (124), Expect = 1e-05
Identities = 48/190 (25%), Positives = 90/190 (47%), Gaps = 20/190 (10%)
Query: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4796
++ ++L + G+ L+G +G GKSTT +++ T G + D D+ +
Sbjct: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSV-----DGQDIRTINVR 464
Query: 4797 GV--LIGYCPQQDAL------DELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRL--HL 4846
+ +IG Q+ L + + G E++ ++ I + A D I +L
Sbjct: 465 FLREIIGVVSQEPVLFATTIAENIRYGRENV----TMDEIEKAVKEANAYDFIMKLPHKF 520
Query: 4847 EAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREG 4906
+ + A SGG K++++ A ALV P ILLLDE +S +D S+ + Q + + R+G
Sbjct: 521 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV-QVALDKARKG 579
Query: 4907 CAAVLTSHSM 4916
++ +H +
Sbjct: 580 RTTIVIAHRL 589
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 88.2 bits (217), Expect = 2e-16
Identities = 60/203 (29%), Positives = 110/203 (54%), Gaps = 8/203 (3%)
Query: 3857 VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNL-QTDLSRVRM 3915
V+Q LSL + Q AL+G++G GK+T++ +L + P +GT++++G+ + ++ +R
Sbjct: 1004 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1063
Query: 3916 ELGVCPQQDILLD-----NLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
+LG+ Q+ IL D N+ ++ + + + K +TL T+
Sbjct: 1064 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD 1123
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
K T+ LSGG K+++++ A + + ++LDE TS +D S + + L K REGRT I
Sbjct: 1124 KGTQ-LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVI 1182
Query: 4031 THHLDEAEALSDRVAVLQHGRLR 4053
H L + +D + V Q+GR++
Sbjct: 1183 AHRLSTIQN-ADLIVVFQNGRVK 1204
Score = 71.6 bits (174), Expect = 2e-11
Identities = 57/222 (25%), Positives = 111/222 (50%), Gaps = 14/222 (6%)
Query: 3819 ENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNG 3878
++F +G + +G LE + V + + +++ L+L Q AL+G++G
Sbjct: 378 DSFSERGHKPDSIKGNLEFND-----VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSG 432
Query: 3879 AGKTTIISMLTGLHPPTSGTIIINGKNLQT-DLSRVRMELGVCPQQDILLDNLTVREHLL 3937
GK+T + ++ L+ P GTI I+G++++ +++ +R +GV Q+ +L + T+ E++
Sbjct: 433 CGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF-STTIAENIC 491
Query: 3938 LFASIKAPQWTKKEL-----HQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMG 3992
KK + ++ + + Q D + + LSGG K+++++ A +
Sbjct: 492 YGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGE--RGAQLSGGQKQRIAIARALVR 549
Query: 3993 MSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHL 4034
+ ++LDE TS +D S + L K REGRT I H L
Sbjct: 550 NPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRL 591
Score = 58.5 bits (140), Expect = 2e-07
Identities = 54/218 (24%), Positives = 97/218 (44%), Gaps = 13/218 (5%)
Query: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSS 4792
N+ +Q +SL + KG+ L+G +G GKST ++L +G ++ G +
Sbjct: 1001 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLD---GQEAKKLN 1057
Query: 4793 AGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAG-----DLIRRL--H 4845
+G Q+ L + E++ Y + R + + I A I L
Sbjct: 1058 VQWLRAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHK 1116
Query: 4846 LEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVRE 4905
E SGG K++++ A AL+ +P ILLLDE +S +D S++ + Q + + RE
Sbjct: 1117 YETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV-QEALDKARE 1175
Query: 4906 GCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHI 4943
G ++ +H + + + + NG K G+ Q +
Sbjct: 1176 GRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1212
Score = 51.2 bits (121), Expect = 3e-05
Identities = 48/189 (25%), Positives = 87/189 (46%), Gaps = 10/189 (5%)
Query: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSS 4792
N+ ++ ++L + G+ L+G +G GKSTT +++ G I G + +
Sbjct: 408 NVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINID---GQDIRNFN 464
Query: 4793 AGTAGVLIGYCPQQDALDELLTGWEHLYY---YCSLRGIPRQCIPEVAGDLIRRL--HLE 4847
+IG Q+ L E++ Y ++ I + A + I +L +
Sbjct: 465 VNYLREIIGVVSQEPVLFSTTIA-ENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFD 523
Query: 4848 AHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGC 4907
+ A SGG K++++ A ALV P ILLLDE +S +D S+ + Q + + REG
Sbjct: 524 TLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGR 582
Query: 4908 AAVLTSHSM 4916
++ +H +
Sbjct: 583 TTIVIAHRL 591
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 88.2 bits (217), Expect = 2e-16
Identities = 60/203 (29%), Positives = 110/203 (54%), Gaps = 8/203 (3%)
Query: 3857 VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNL-QTDLSRVRM 3915
V+Q LSL + Q AL+G++G GK+T++ +L + P +GT++++G+ + ++ +R
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1110
Query: 3916 ELGVCPQQDILLD-----NLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
+LG+ Q+ IL D N+ ++ + + + K +TL T+
Sbjct: 1111 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD 1170
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
K T+ LSGG K+++++ A + + ++LDE TS +D S + + L K REGRT I
Sbjct: 1171 KGTQ-LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVI 1229
Query: 4031 THHLDEAEALSDRVAVLQHGRLR 4053
H L + +D + V Q+GR++
Sbjct: 1230 AHRLSTIQN-ADLIVVFQNGRVK 1251
Score = 71.6 bits (174), Expect = 2e-11
Identities = 57/222 (25%), Positives = 111/222 (50%), Gaps = 14/222 (6%)
Query: 3819 ENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNG 3878
++F +G + +G LE + V + + +++ L+L Q AL+G++G
Sbjct: 378 DSFSERGHKPDSIKGNLEFND-----VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSG 432
Query: 3879 AGKTTIISMLTGLHPPTSGTIIINGKNLQT-DLSRVRMELGVCPQQDILLDNLTVREHLL 3937
GK+T + ++ L+ P GTI I+G++++ +++ +R +GV Q+ +L + T+ E++
Sbjct: 433 CGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF-STTIAENIC 491
Query: 3938 LFASIKAPQWTKKEL-----HQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMG 3992
KK + ++ + + Q D + + LSGG K+++++ A +
Sbjct: 492 YGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGE--RGAQLSGGQKQRIAIARALVR 549
Query: 3993 MSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHL 4034
+ ++LDE TS +D S + L K REGRT I H L
Sbjct: 550 NPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRL 591
Score = 58.5 bits (140), Expect = 2e-07
Identities = 54/218 (24%), Positives = 97/218 (44%), Gaps = 13/218 (5%)
Query: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSS 4792
N+ +Q +SL + KG+ L+G +G GKST ++L +G ++ G +
Sbjct: 1048 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLD---GQEAKKLN 1104
Query: 4793 AGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAG-----DLIRRL--H 4845
+G Q+ L + E++ Y + R + + I A I L
Sbjct: 1105 VQWLRAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHK 1163
Query: 4846 LEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVRE 4905
E SGG K++++ A AL+ +P ILLLDE +S +D S++ + Q + + RE
Sbjct: 1164 YETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV-QEALDKARE 1222
Query: 4906 GCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHI 4943
G ++ +H + + + + NG K G+ Q +
Sbjct: 1223 GRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1259
Score = 51.2 bits (121), Expect = 3e-05
Identities = 48/189 (25%), Positives = 87/189 (46%), Gaps = 10/189 (5%)
Query: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSS 4792
N+ ++ ++L + G+ L+G +G GKSTT +++ G I G + +
Sbjct: 408 NVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINID---GQDIRNFN 464
Query: 4793 AGTAGVLIGYCPQQDALDELLTGWEHLYY---YCSLRGIPRQCIPEVAGDLIRRL--HLE 4847
+IG Q+ L E++ Y ++ I + A + I +L +
Sbjct: 465 VNYLREIIGVVSQEPVLFSTTIA-ENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFD 523
Query: 4848 AHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGC 4907
+ A SGG K++++ A ALV P ILLLDE +S +D S+ + Q + + REG
Sbjct: 524 TLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGR 582
Query: 4908 AAVLTSHSM 4916
++ +H +
Sbjct: 583 TTIVIAHRL 591
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 86.7 bits (213), Expect = 5e-16
Identities = 59/203 (29%), Positives = 108/203 (53%), Gaps = 6/203 (2%)
Query: 3852 EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDL 3910
+G+K +++ +S F ++ A++G +GAGK+T++++L G G ++ING L DL
Sbjct: 92 KGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDL 149
Query: 3911 SRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
R Q D+LL +LTV+E +++ A +K Q + + V + L + L +
Sbjct: 150 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL-QEKDEGRREMVKEILTALGLLSCAN 208
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
+T +LSGG +++L++ + + + DEPTSG+D S + ++ +G I
Sbjct: 209 TRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIIC 268
Query: 4031 THHLDEAE--ALSDRVAVLQHGR 4051
T H A+ L D++ VL G+
Sbjct: 269 TIHQPSAKLFELFDQLYVLSQGQ 291
Score = 52.0 bits (123), Expect = 1e-05
Identities = 48/176 (27%), Positives = 83/176 (47%), Gaps = 7/176 (3%)
Query: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4796
++ IS GE ++G +GAGKST +L G A++ G DL
Sbjct: 98 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN--GLPRDLRCFRKV 155
Query: 4797 GVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPR-QCIPEVAGDLIRRLHLEAHADKPVA 4855
Y Q D L LT E + L+ + + E+ +++ L L + A+
Sbjct: 156 SC---YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTG 212
Query: 4856 TYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
+ SGG +++L+ AL LV P ++ DEP+SG+D S + ++MK + +G +++
Sbjct: 213 SLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKGLAQGGRSII 267
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 86.7 bits (213), Expect = 5e-16
Identities = 59/203 (29%), Positives = 108/203 (53%), Gaps = 6/203 (2%)
Query: 3852 EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDL 3910
+G+K +++ +S F ++ A++G +GAGK+T++++L G G ++ING L DL
Sbjct: 73 KGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDL 130
Query: 3911 SRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
R Q D+LL +LTV+E +++ A +K Q + + V + L + L +
Sbjct: 131 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL-QEKDEGRREMVKEILTALGLLSCAN 189
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
+T +LSGG +++L++ + + + DEPTSG+D S + ++ +G I
Sbjct: 190 TRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIIC 249
Query: 4031 THHLDEAE--ALSDRVAVLQHGR 4051
T H A+ L D++ VL G+
Sbjct: 250 TIHQPSAKLFELFDQLYVLSQGQ 272
Score = 52.0 bits (123), Expect = 1e-05
Identities = 48/176 (27%), Positives = 83/176 (47%), Gaps = 7/176 (3%)
Query: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4796
++ IS GE ++G +GAGKST +L G A++ G DL
Sbjct: 79 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN--GLPRDLRCFRKV 136
Query: 4797 GVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPR-QCIPEVAGDLIRRLHLEAHADKPVA 4855
Y Q D L LT E + L+ + + E+ +++ L L + A+
Sbjct: 137 SC---YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTG 193
Query: 4856 TYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
+ SGG +++L+ AL LV P ++ DEP+SG+D S + ++MK + +G +++
Sbjct: 194 SLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKGLAQGGRSII 248
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 86.7 bits (213), Expect = 5e-16
Identities = 59/203 (29%), Positives = 108/203 (53%), Gaps = 6/203 (2%)
Query: 3852 EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDL 3910
+G+K +++ +S F ++ A++G +GAGK+T++++L G G ++ING L DL
Sbjct: 97 KGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDL 154
Query: 3911 SRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
R Q D+LL +LTV+E +++ A +K Q + + V + L + L +
Sbjct: 155 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL-QEKDEGRREMVKEILTALGLLSCAN 213
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
+T +LSGG +++L++ + + + DEPTSG+D S + ++ +G I
Sbjct: 214 TRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIIC 273
Query: 4031 THHLDEAE--ALSDRVAVLQHGR 4051
T H A+ L D++ VL G+
Sbjct: 274 TIHQPSAKLFELFDQLYVLSQGQ 296
Score = 52.0 bits (123), Expect = 1e-05
Identities = 48/176 (27%), Positives = 83/176 (47%), Gaps = 7/176 (3%)
Query: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4796
++ IS GE ++G +GAGKST +L G A++ G DL
Sbjct: 103 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN--GLPRDLRCFRKV 160
Query: 4797 GVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPR-QCIPEVAGDLIRRLHLEAHADKPVA 4855
Y Q D L LT E + L+ + + E+ +++ L L + A+
Sbjct: 161 SC---YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTG 217
Query: 4856 TYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
+ SGG +++L+ AL LV P ++ DEP+SG+D S + ++MK + +G +++
Sbjct: 218 SLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKGLAQGGRSII 272
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 86.7 bits (213), Expect = 5e-16
Identities = 59/203 (29%), Positives = 108/203 (53%), Gaps = 6/203 (2%)
Query: 3852 EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDL 3910
+G+K +++ +S F ++ A++G +GAGK+T++++L G G ++ING L DL
Sbjct: 106 KGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDL 163
Query: 3911 SRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
R Q D+LL +LTV+E +++ A +K Q + + V + L + L +
Sbjct: 164 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL-QEKDEGRREMVKEILTALGLLSCAN 222
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
+T +LSGG +++L++ + + + DEPTSG+D S + ++ +G I
Sbjct: 223 TRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIIC 282
Query: 4031 THHLDEAE--ALSDRVAVLQHGR 4051
T H A+ L D++ VL G+
Sbjct: 283 TIHQPSAKLFELFDQLYVLSQGQ 305
Score = 52.0 bits (123), Expect = 1e-05
Identities = 48/176 (27%), Positives = 83/176 (47%), Gaps = 7/176 (3%)
Query: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4796
++ IS GE ++G +GAGKST +L G A++ G DL
Sbjct: 112 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN--GLPRDLRCFRKV 169
Query: 4797 GVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPR-QCIPEVAGDLIRRLHLEAHADKPVA 4855
Y Q D L LT E + L+ + + E+ +++ L L + A+
Sbjct: 170 SC---YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTG 226
Query: 4856 TYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
+ SGG +++L+ AL LV P ++ DEP+SG+D S + ++MK + +G +++
Sbjct: 227 SLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKGLAQGGRSII 281
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 86.7 bits (213), Expect = 5e-16
Identities = 59/203 (29%), Positives = 108/203 (53%), Gaps = 6/203 (2%)
Query: 3852 EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDL 3910
+G+K +++ +S F ++ A++G +GAGK+T++++L G G ++ING L DL
Sbjct: 95 KGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDL 152
Query: 3911 SRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
R Q D+LL +LTV+E +++ A +K Q + + V + L + L +
Sbjct: 153 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL-QEKDEGRREMVKEILTALGLLSCAN 211
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
+T +LSGG +++L++ + + + DEPTSG+D S + ++ +G I
Sbjct: 212 TRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIIC 271
Query: 4031 THHLDEAE--ALSDRVAVLQHGR 4051
T H A+ L D++ VL G+
Sbjct: 272 TIHQPSAKLFELFDQLYVLSQGQ 294
Score = 52.0 bits (123), Expect = 1e-05
Identities = 48/176 (27%), Positives = 83/176 (47%), Gaps = 7/176 (3%)
Query: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4796
++ IS GE ++G +GAGKST +L G A++ G DL
Sbjct: 101 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN--GLPRDLRCFRKV 158
Query: 4797 GVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPR-QCIPEVAGDLIRRLHLEAHADKPVA 4855
Y Q D L LT E + L+ + + E+ +++ L L + A+
Sbjct: 159 SC---YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTG 215
Query: 4856 TYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
+ SGG +++L+ AL LV P ++ DEP+SG+D S + ++MK + +G +++
Sbjct: 216 SLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKGLAQGGRSII 270
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 86.7 bits (213), Expect = 5e-16
Identities = 59/203 (29%), Positives = 108/203 (53%), Gaps = 6/203 (2%)
Query: 3852 EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDL 3910
+G+K +++ +S F ++ A++G +GAGK+T++++L G G ++ING L DL
Sbjct: 95 KGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDL 152
Query: 3911 SRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970
R Q D+LL +LTV+E +++ A +K Q + + V + L + L +
Sbjct: 153 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL-QEKDEGRREMVKEILTALGLLSCAN 211
Query: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030
+T +LSGG +++L++ + + + DEPTSG+D S + ++ +G I
Sbjct: 212 TRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIIC 271
Query: 4031 THHLDEAE--ALSDRVAVLQHGR 4051
T H A+ L D++ VL G+
Sbjct: 272 TIHQPSAKLFELFDQLYVLSQGQ 294
Score = 52.0 bits (123), Expect = 1e-05
Identities = 48/176 (27%), Positives = 83/176 (47%), Gaps = 7/176 (3%)
Query: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4796
++ IS GE ++G +GAGKST +L G A++ G DL
Sbjct: 101 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN--GLPRDLRCFRKV 158
Query: 4797 GVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPR-QCIPEVAGDLIRRLHLEAHADKPVA 4855
Y Q D L LT E + L+ + + E+ +++ L L + A+
Sbjct: 159 SC---YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTG 215
Query: 4856 TYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911
+ SGG +++L+ AL LV P ++ DEP+SG+D S + ++MK + +G +++
Sbjct: 216 SLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKGLAQGGRSII 270
>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
Length = 655
Score = 85.9 bits (211), Expect = 9e-16
Identities = 58/198 (29%), Positives = 108/198 (54%), Gaps = 13/198 (6%)
Query: 3870 ITALLGTNGAGKTTIISMLTGLHPPT--SGTIIINGKNLQTDLSRVRMELGVCPQQDILL 3927
+ A+LG G GK++++ +L P+ SG ++ING + + G Q D+++
Sbjct: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF---KCNSGYVVQDDVVM 131
Query: 3928 DNLTVREHLLLFASIK-APQWTKKELHQQVNQTLQDVDLTQHQHKQT-----RALSGGLK 3981
LTVRE+L A+++ A T E ++++N+ +Q++ L + + R +SGG +
Sbjct: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
Query: 3982 RKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKY-REGRTIIFTTHH-LDEAEA 4039
++ S+G+ + + LDEPT+G+D + +++ +L + ++GRTIIF+ H
Sbjct: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
Query: 4040 LSDRVAVLQHGRLRCCGP 4057
L D + +L GRL GP
Sbjct: 252 LFDSLTLLASGRLMFHGP 269
Score = 51.6 bits (122), Expect = 2e-05
Identities = 49/182 (26%), Positives = 80/182 (43%), Gaps = 17/182 (9%)
Query: 4743 GIPKGECFGLLGVNGAGKSTTFKMLNG--EVSLTSGHAIIRTPMGDAVDLSSAGTAGVLI 4800
GI K +LG G GKS+ +L + S SG +I A ++G
Sbjct: 69 GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSG------ 122
Query: 4801 GYCPQQDALDELLTGWEHLYYYCSLR---GIPRQCIPEVAGDLIRRLHLEAHADKPVATY 4857
Y Q D + LT E+L + +LR + E +I+ L L+ AD V T
Sbjct: 123 -YVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQ 181
Query: 4858 -----SGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLT 4912
SGG +++ S + L+ P IL LDEP++G+D + + + + ++G + +
Sbjct: 182 FIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFS 241
Query: 4913 SH 4914
H
Sbjct: 242 IH 243
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 175,446,315
Number of Sequences: 37866
Number of extensions: 7529537
Number of successful extensions: 20215
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 19349
Number of HSP's gapped (non-prelim): 525
length of query: 5058
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4934
effective length of database: 13,552,134
effective search space: 66866229156
effective search space used: 66866229156
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.