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Search of human proteins with 31542747
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31542747 catechol-O-methyltransferase domain containing 1
[Homo sapiens]
(262 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31542747 catechol-O-methyltransferase domain containing 1 [Ho... 521 e-148
gi|223718169 leucine rich transmembrane and 0-methyltransferase ... 48 8e-06
gi|223718164 leucine rich transmembrane and 0-methyltransferase ... 48 8e-06
gi|223718159 leucine rich transmembrane and 0-methyltransferase ... 48 8e-06
gi|6466450 catechol-O-methyltransferase isoform S-COMT [Homo sap... 40 0.003
gi|205830453 catechol-O-methyltransferase isoform MB-COMT [Homo ... 40 0.003
gi|205830451 catechol-O-methyltransferase isoform MB-COMT [Homo ... 40 0.003
gi|4502969 catechol-O-methyltransferase isoform MB-COMT [Homo sa... 40 0.003
gi|239755008 PREDICTED: hypothetical protein [Homo sapiens] 30 2.1
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap... 29 4.8
gi|11141903 FAST kinase domains 5 [Homo sapiens] 29 4.8
gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens] 28 6.2
gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens] 28 6.2
gi|14028875 solute carrier family 35 (UDP-glucuronic acid/UDP-N-... 28 8.1
>gi|31542747 catechol-O-methyltransferase domain containing 1 [Homo
sapiens]
Length = 262
Score = 521 bits (1343), Expect = e-148
Identities = 262/262 (100%), Positives = 262/262 (100%)
Query: 1 MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLS 60
MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLS
Sbjct: 1 MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLS 60
Query: 61 RSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALAL 120
RSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALAL
Sbjct: 61 RSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALAL 120
Query: 121 ALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFD 180
ALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFD
Sbjct: 121 ALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFD 180
Query: 181 VAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIR 240
VAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIR
Sbjct: 181 VAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIR 240
Query: 241 RDVRVYISLLPLGDGLTLAFKI 262
RDVRVYISLLPLGDGLTLAFKI
Sbjct: 241 RDVRVYISLLPLGDGLTLAFKI 262
>gi|223718169 leucine rich transmembrane and 0-methyltransferase
domain containing isoform 6 [Homo sapiens]
Length = 251
Score = 48.1 bits (113), Expect = 8e-06
Identities = 41/130 (31%), Positives = 63/130 (48%), Gaps = 8/130 (6%)
Query: 97 LARLIQAKK---ALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAE-A 152
L RL++ K L+LGT+ GYS L +A ALP GR++T E D + + L R A
Sbjct: 83 LMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFD 142
Query: 153 EHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLR 212
EH ++L + + + + L + D+ ++ A + C Y R LQLL +L
Sbjct: 143 EHMVELIVGSSEDVIPCLRTQYQLSRADLVLL-AHRPRC---YLRDLQLLEAHALLPAGA 198
Query: 213 VLWRGKVLQP 222
+ VL P
Sbjct: 199 TVLADHVLFP 208
>gi|223718164 leucine rich transmembrane and 0-methyltransferase
domain containing isoform 4 [Homo sapiens]
Length = 291
Score = 48.1 bits (113), Expect = 8e-06
Identities = 41/130 (31%), Positives = 63/130 (48%), Gaps = 8/130 (6%)
Query: 97 LARLIQAKK---ALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAE-A 152
L RL++ K L+LGT+ GYS L +A ALP GR++T E D + + L R A
Sbjct: 123 LMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFD 182
Query: 153 EHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLR 212
EH ++L + + + + L + D+ ++ A + C Y R LQLL +L
Sbjct: 183 EHMVELIVGSSEDVIPCLRTQYQLSRADLVLL-AHRPRC---YLRDLQLLEAHALLPAGA 238
Query: 213 VLWRGKVLQP 222
+ VL P
Sbjct: 239 TVLADHVLFP 248
>gi|223718159 leucine rich transmembrane and 0-methyltransferase
domain containing isoform 4 [Homo sapiens]
Length = 291
Score = 48.1 bits (113), Expect = 8e-06
Identities = 41/130 (31%), Positives = 63/130 (48%), Gaps = 8/130 (6%)
Query: 97 LARLIQAKK---ALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAE-A 152
L RL++ K L+LGT+ GYS L +A ALP GR++T E D + + L R A
Sbjct: 123 LMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFD 182
Query: 153 EHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLR 212
EH ++L + + + + L + D+ ++ A + C Y R LQLL +L
Sbjct: 183 EHMVELIVGSSEDVIPCLRTQYQLSRADLVLL-AHRPRC---YLRDLQLLEAHALLPAGA 238
Query: 213 VLWRGKVLQP 222
+ VL P
Sbjct: 239 TVLADHVLFP 248
>gi|6466450 catechol-O-methyltransferase isoform S-COMT [Homo
sapiens]
Length = 221
Score = 39.7 bits (91), Expect = 0.003
Identities = 34/135 (25%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 102 QAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLK 161
Q L+LG + GYSA+ +A L R++T E++ + + + A + K+ L +
Sbjct: 58 QPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVG 117
Query: 162 PALETLDELLAAGEAGTFDVAVVDADKENC---SAYYERCLQLLRPGGILAVLRVLWRG- 217
+ + + +L + T D+ +D K+ + E C LLR G +L V+ G
Sbjct: 118 ASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEEC-GLLRKGTVLLADNVICPGA 176
Query: 218 -KVLQPPKGDVAAEC 231
L +G EC
Sbjct: 177 PDFLAHVRGSSCFEC 191
>gi|205830453 catechol-O-methyltransferase isoform MB-COMT [Homo
sapiens]
Length = 271
Score = 39.7 bits (91), Expect = 0.003
Identities = 34/135 (25%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 102 QAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLK 161
Q L+LG + GYSA+ +A L R++T E++ + + + A + K+ L +
Sbjct: 108 QPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVG 167
Query: 162 PALETLDELLAAGEAGTFDVAVVDADKENC---SAYYERCLQLLRPGGILAVLRVLWRG- 217
+ + + +L + T D+ +D K+ + E C LLR G +L V+ G
Sbjct: 168 ASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEEC-GLLRKGTVLLADNVICPGA 226
Query: 218 -KVLQPPKGDVAAEC 231
L +G EC
Sbjct: 227 PDFLAHVRGSSCFEC 241
>gi|205830451 catechol-O-methyltransferase isoform MB-COMT [Homo
sapiens]
Length = 271
Score = 39.7 bits (91), Expect = 0.003
Identities = 34/135 (25%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 102 QAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLK 161
Q L+LG + GYSA+ +A L R++T E++ + + + A + K+ L +
Sbjct: 108 QPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVG 167
Query: 162 PALETLDELLAAGEAGTFDVAVVDADKENC---SAYYERCLQLLRPGGILAVLRVLWRG- 217
+ + + +L + T D+ +D K+ + E C LLR G +L V+ G
Sbjct: 168 ASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEEC-GLLRKGTVLLADNVICPGA 226
Query: 218 -KVLQPPKGDVAAEC 231
L +G EC
Sbjct: 227 PDFLAHVRGSSCFEC 241
>gi|4502969 catechol-O-methyltransferase isoform MB-COMT [Homo
sapiens]
Length = 271
Score = 39.7 bits (91), Expect = 0.003
Identities = 34/135 (25%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 102 QAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLK 161
Q L+LG + GYSA+ +A L R++T E++ + + + A + K+ L +
Sbjct: 108 QPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVG 167
Query: 162 PALETLDELLAAGEAGTFDVAVVDADKENC---SAYYERCLQLLRPGGILAVLRVLWRG- 217
+ + + +L + T D+ +D K+ + E C LLR G +L V+ G
Sbjct: 168 ASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEEC-GLLRKGTVLLADNVICPGA 226
Query: 218 -KVLQPPKGDVAAEC 231
L +G EC
Sbjct: 227 PDFLAHVRGSSCFEC 241
>gi|239755008 PREDICTED: hypothetical protein [Homo sapiens]
Length = 253
Score = 30.0 bits (66), Expect = 2.1
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 6/74 (8%)
Query: 114 GYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLK------PALETL 167
G L L LA+ ADG V+ + A P +GR Q A ++++ A + L
Sbjct: 169 GDERLGLLLAIQADGPVLRPHLGATIPPVGRERAAQQGAIAAAGVKVQRAGAEGQAEDLL 228
Query: 168 DELLAAGEAGTFDV 181
L+A GEA +F V
Sbjct: 229 SLLIADGEAASFQV 242
>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo
sapiens]
Length = 504
Score = 28.9 bits (63), Expect = 4.8
Identities = 30/85 (35%), Positives = 39/85 (45%), Gaps = 5/85 (5%)
Query: 152 AEHKIDLRLKPALETLDELLAAGE---AGTFDVAVVDADKENCSAYYERCLQLLRPGGIL 208
AE ++ ++ LE +LLAAG+ A + A VD D +N AYY R L G
Sbjct: 29 AECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSK 88
Query: 209 AVLRVLWRGKVLQPPKGDVAAECVR 233
A L L KV+Q AA R
Sbjct: 89 AALPDL--TKVIQLKMDFTAARLQR 111
>gi|11141903 FAST kinase domains 5 [Homo sapiens]
Length = 764
Score = 28.9 bits (63), Expect = 4.8
Identities = 14/37 (37%), Positives = 17/37 (45%)
Query: 31 LGRRCPPWRGRREQCLLPPEDSRLWQYLLSRSMREHP 67
+G CP +RG R L E S L YL + M P
Sbjct: 521 VGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKP 557
>gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens]
Length = 929
Score = 28.5 bits (62), Expect = 6.2
Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 5/85 (5%)
Query: 164 LETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPP 223
L+T + AA +A +D + + A Y RC L G + + + R L+ P
Sbjct: 54 LKTESYVQAASDASR----AIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLE-P 108
Query: 224 KGDVAAECVRNLNERIRRDVRVYIS 248
+ E +R LN I+ +RV S
Sbjct: 109 RNQNFQEMLRRLNTSIQEKLRVQFS 133
>gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens]
Length = 931
Score = 28.5 bits (62), Expect = 6.2
Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 5/85 (5%)
Query: 164 LETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPP 223
L+T + AA +A +D + + A Y RC L G + + + R L+ P
Sbjct: 54 LKTESYVQAASDASR----AIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLE-P 108
Query: 224 KGDVAAECVRNLNERIRRDVRVYIS 248
+ E +R LN I+ +RV S
Sbjct: 109 RNQNFQEMLRRLNTSIQEKLRVQFS 133
>gi|14028875 solute carrier family 35 (UDP-glucuronic
acid/UDP-N-acetylgalactosamine dual transporter), member
D1 [Homo sapiens]
Length = 355
Score = 28.1 bits (61), Expect = 8.1
Identities = 20/72 (27%), Positives = 32/72 (44%)
Query: 153 EHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLR 212
E ++ + L +LLAAG G +V +K + Y + G ++A +
Sbjct: 26 EEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQMVATVA 85
Query: 213 VLWRGKVLQPPK 224
VLW GK L+ K
Sbjct: 86 VLWVGKALRVVK 97
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,463,767
Number of Sequences: 37866
Number of extensions: 460950
Number of successful extensions: 1103
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1093
Number of HSP's gapped (non-prelim): 15
length of query: 262
length of database: 18,247,518
effective HSP length: 100
effective length of query: 162
effective length of database: 14,460,918
effective search space: 2342668716
effective search space used: 2342668716
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.