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Search of human proteins with 30795238
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30795238 ATP-binding cassette, sub-family A, member 12
isoform a [Homo sapiens]
(2595 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 5170 0.0
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 4519 0.0
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 1454 0.0
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 1179 0.0
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 1119 0.0
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 1021 0.0
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 1018 0.0
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 1018 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 476 e-133
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 290 1e-77
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 290 1e-77
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 277 9e-74
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 270 1e-71
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 268 4e-71
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 236 2e-61
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 146 3e-34
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 146 3e-34
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 146 3e-34
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 91 1e-17
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 91 1e-17
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 91 1e-17
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 91 1e-17
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 91 1e-17
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 91 1e-17
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 87 2e-16
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 87 2e-16
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 87 2e-16
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s... 87 3e-16
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa... 87 3e-16
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 82 5e-15
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 5170 bits (13412), Expect = 0.0
Identities = 2595/2595 (100%), Positives = 2595/2595 (100%)
Query: 1 MASLFHQLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPR 60
MASLFHQLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPR
Sbjct: 1 MASLFHQLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPR 60
Query: 61 NLPSTGFFPFLQTLLCDTDSKCKDTPYGPQDLLRRKGIDDALFKDSEILRKSSNLDKDSS 120
NLPSTGFFPFLQTLLCDTDSKCKDTPYGPQDLLRRKGIDDALFKDSEILRKSSNLDKDSS
Sbjct: 61 NLPSTGFFPFLQTLLCDTDSKCKDTPYGPQDLLRRKGIDDALFKDSEILRKSSNLDKDSS 120
Query: 121 LSFQSTQVPERRHASLATVFPSPSSDLEIPGTYTFNGSQVLARILGLEKLLKQNSTSEDI 180
LSFQSTQVPERRHASLATVFPSPSSDLEIPGTYTFNGSQVLARILGLEKLLKQNSTSEDI
Sbjct: 121 LSFQSTQVPERRHASLATVFPSPSSDLEIPGTYTFNGSQVLARILGLEKLLKQNSTSEDI 180
Query: 181 RRELCDSYSGYIVDDAFSWTFLGRNVFNKFCLSNMTLLESSLQELNKQFSQLSSDPNNQK 240
RRELCDSYSGYIVDDAFSWTFLGRNVFNKFCLSNMTLLESSLQELNKQFSQLSSDPNNQK
Sbjct: 181 RRELCDSYSGYIVDDAFSWTFLGRNVFNKFCLSNMTLLESSLQELNKQFSQLSSDPNNQK 240
Query: 241 IVFQEIVRMLSFFSQVQEQKAVWQLLSSFPNVFQNDTSLSNLFDVLRKANSVLLVVQKVY 300
IVFQEIVRMLSFFSQVQEQKAVWQLLSSFPNVFQNDTSLSNLFDVLRKANSVLLVVQKVY
Sbjct: 241 IVFQEIVRMLSFFSQVQEQKAVWQLLSSFPNVFQNDTSLSNLFDVLRKANSVLLVVQKVY 300
Query: 301 PRFATNEGFRTLQKSVKHLLYTLDSPAQGDSDNITHVWNEDDGQTLSPSSLAAQLLILEN 360
PRFATNEGFRTLQKSVKHLLYTLDSPAQGDSDNITHVWNEDDGQTLSPSSLAAQLLILEN
Sbjct: 301 PRFATNEGFRTLQKSVKHLLYTLDSPAQGDSDNITHVWNEDDGQTLSPSSLAAQLLILEN 360
Query: 361 FEDALLNISANSPYIPYLACVRNVTDSLARGSPENLRLLQSTIRFKKSFLRNGSYEDYFP 420
FEDALLNISANSPYIPYLACVRNVTDSLARGSPENLRLLQSTIRFKKSFLRNGSYEDYFP
Sbjct: 361 FEDALLNISANSPYIPYLACVRNVTDSLARGSPENLRLLQSTIRFKKSFLRNGSYEDYFP 420
Query: 421 PVPEVLKSKLSQLRNLTELLCESETFSLIEKSCQLSDMSFGSLCEESEFDLQLLEAAELG 480
PVPEVLKSKLSQLRNLTELLCESETFSLIEKSCQLSDMSFGSLCEESEFDLQLLEAAELG
Sbjct: 421 PVPEVLKSKLSQLRNLTELLCESETFSLIEKSCQLSDMSFGSLCEESEFDLQLLEAAELG 480
Query: 481 TEIAASLLYHDNVISKKVRDLLTGDPSKINLNMDQFLEQALQMNYLENITQLIPIIEAML 540
TEIAASLLYHDNVISKKVRDLLTGDPSKINLNMDQFLEQALQMNYLENITQLIPIIEAML
Sbjct: 481 TEIAASLLYHDNVISKKVRDLLTGDPSKINLNMDQFLEQALQMNYLENITQLIPIIEAML 540
Query: 541 HVNNSADASEKPGQLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAIPIPDNRAEIISQVF 600
HVNNSADASEKPGQLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAIPIPDNRAEIISQVF
Sbjct: 541 HVNNSADASEKPGQLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAIPIPDNRAEIISQVF 600
Query: 601 WLHSCDTNITTPKLEDAMKEFCNLSLSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQ 660
WLHSCDTNITTPKLEDAMKEFCNLSLSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQ
Sbjct: 601 WLHSCDTNITTPKLEDAMKEFCNLSLSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQ 660
Query: 661 KPVEKMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQG 720
KPVEKMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQG
Sbjct: 661 KPVEKMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQG 720
Query: 721 SFSTISQALCSQGITTEYLTAMLPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPF 780
SFSTISQALCSQGITTEYLTAMLPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPF
Sbjct: 721 SFSTISQALCSQGITTEYLTAMLPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPF 780
Query: 781 CFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQ 840
CFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQ
Sbjct: 781 CFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQ 840
Query: 841 EWMDKSPLFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLK 900
EWMDKSPLFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLK
Sbjct: 841 EWMDKSPLFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLK 900
Query: 901 LENNIDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKL 960
LENNIDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKL
Sbjct: 901 LENNIDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKL 960
Query: 961 PSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRA 1020
PSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRA
Sbjct: 961 PSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRA 1020
Query: 1021 FIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVF 1080
FIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVF
Sbjct: 1021 FIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVF 1080
Query: 1081 IAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILP 1140
IAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILP
Sbjct: 1081 IAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILP 1140
Query: 1141 KTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENEL 1200
KTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENEL
Sbjct: 1141 KTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENEL 1200
Query: 1201 SYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILAD 1260
SYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILAD
Sbjct: 1201 SYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILAD 1260
Query: 1261 SFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQN 1320
SFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQN
Sbjct: 1261 SFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQN 1320
Query: 1321 TNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPN 1380
TNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPN
Sbjct: 1321 TNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPN 1380
Query: 1381 GAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLL 1440
GAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLL
Sbjct: 1381 GAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLL 1440
Query: 1441 LYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVV 1500
LYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVV
Sbjct: 1441 LYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVV 1500
Query: 1501 ILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGS 1560
ILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGS
Sbjct: 1501 ILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGS 1560
Query: 1561 PFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVL 1620
PFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVL
Sbjct: 1561 PFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVL 1620
Query: 1621 PPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLT 1680
PPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLT
Sbjct: 1621 PPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLT 1680
Query: 1681 QKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHT 1740
QKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHT
Sbjct: 1681 QKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHT 1740
Query: 1741 RRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPST 1800
RRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPST
Sbjct: 1741 RRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPST 1800
Query: 1801 EALVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFN 1860
EALVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFN
Sbjct: 1801 EALVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFN 1860
Query: 1861 YSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPA 1920
YSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPA
Sbjct: 1861 YSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPA 1920
Query: 1921 NRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYPGVQDQEQAT 1980
NRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYPGVQDQEQAT
Sbjct: 1921 NRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYPGVQDQEQAT 1980
Query: 1981 ISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMV 2040
ISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMV
Sbjct: 1981 ISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMV 2040
Query: 2041 FYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFI 2100
FYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFI
Sbjct: 2041 FYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFI 2100
Query: 2101 TYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELS 2160
TYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELS
Sbjct: 2101 TYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELS 2160
Query: 2161 QQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFR 2220
QQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFR
Sbjct: 2161 QQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFR 2220
Query: 2221 KFNSSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGI 2280
KFNSSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGI
Sbjct: 2221 KFNSSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGI 2280
Query: 2281 PAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQED 2340
PAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQED
Sbjct: 2281 PAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQED 2340
Query: 2341 ALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLST 2400
ALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLST
Sbjct: 2341 ALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLST 2400
Query: 2401 ALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLA 2460
ALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLA
Sbjct: 2401 ALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLA 2460
Query: 2461 IMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSM 2520
IMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSM
Sbjct: 2461 IMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSM 2520
Query: 2521 LEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQ 2580
LEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQ
Sbjct: 2521 LEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQ 2580
Query: 2581 GSTISVDSQDDQMES 2595
GSTISVDSQDDQMES
Sbjct: 2581 GSTISVDSQDDQMES 2595
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 4519 bits (11720), Expect = 0.0
Identities = 2267/2267 (100%), Positives = 2267/2267 (100%)
Query: 329 GDSDNITHVWNEDDGQTLSPSSLAAQLLILENFEDALLNISANSPYIPYLACVRNVTDSL 388
GDSDNITHVWNEDDGQTLSPSSLAAQLLILENFEDALLNISANSPYIPYLACVRNVTDSL
Sbjct: 11 GDSDNITHVWNEDDGQTLSPSSLAAQLLILENFEDALLNISANSPYIPYLACVRNVTDSL 70
Query: 389 ARGSPENLRLLQSTIRFKKSFLRNGSYEDYFPPVPEVLKSKLSQLRNLTELLCESETFSL 448
ARGSPENLRLLQSTIRFKKSFLRNGSYEDYFPPVPEVLKSKLSQLRNLTELLCESETFSL
Sbjct: 71 ARGSPENLRLLQSTIRFKKSFLRNGSYEDYFPPVPEVLKSKLSQLRNLTELLCESETFSL 130
Query: 449 IEKSCQLSDMSFGSLCEESEFDLQLLEAAELGTEIAASLLYHDNVISKKVRDLLTGDPSK 508
IEKSCQLSDMSFGSLCEESEFDLQLLEAAELGTEIAASLLYHDNVISKKVRDLLTGDPSK
Sbjct: 131 IEKSCQLSDMSFGSLCEESEFDLQLLEAAELGTEIAASLLYHDNVISKKVRDLLTGDPSK 190
Query: 509 INLNMDQFLEQALQMNYLENITQLIPIIEAMLHVNNSADASEKPGQLLEMFKNVEELKED 568
INLNMDQFLEQALQMNYLENITQLIPIIEAMLHVNNSADASEKPGQLLEMFKNVEELKED
Sbjct: 191 INLNMDQFLEQALQMNYLENITQLIPIIEAMLHVNNSADASEKPGQLLEMFKNVEELKED 250
Query: 569 LRRTTGMSNRTIDKLLAIPIPDNRAEIISQVFWLHSCDTNITTPKLEDAMKEFCNLSLSE 628
LRRTTGMSNRTIDKLLAIPIPDNRAEIISQVFWLHSCDTNITTPKLEDAMKEFCNLSLSE
Sbjct: 251 LRRTTGMSNRTIDKLLAIPIPDNRAEIISQVFWLHSCDTNITTPKLEDAMKEFCNLSLSE 310
Query: 629 RSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQKPVEKMMELFIRLKEILNQMASGTHPLL 688
RSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQKPVEKMMELFIRLKEILNQMASGTHPLL
Sbjct: 311 RSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQKPVEKMMELFIRLKEILNQMASGTHPLL 370
Query: 689 DKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQGSFSTISQALCSQGITTEYLTAMLPSSQR 748
DKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQGSFSTISQALCSQGITTEYLTAMLPSSQR
Sbjct: 371 DKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQGSFSTISQALCSQGITTEYLTAMLPSSQR 430
Query: 749 PKGNHTKDFLTYKLTKEQIASKYGIPINSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGR 808
PKGNHTKDFLTYKLTKEQIASKYGIPINSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGR
Sbjct: 431 PKGNHTKDFLTYKLTKEQIASKYGIPINSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGR 490
Query: 809 ILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLR 868
ILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLR
Sbjct: 491 ILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLR 550
Query: 869 NPFVQVFVKFSVGLDAVELLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSCVLYD 928
NPFVQVFVKFSVGLDAVELLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSCVLYD
Sbjct: 551 NPFVQVFVKFSVGLDAVELLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSCVLYD 610
Query: 929 RIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMS 988
RIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMS
Sbjct: 611 RIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMS 670
Query: 989 LKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQV 1048
LKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQV
Sbjct: 671 LKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQV 730
Query: 1049 QAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSC 1108
QAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSC
Sbjct: 731 QAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSC 790
Query: 1109 SHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVF 1168
SHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVF
Sbjct: 791 SHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVF 850
Query: 1169 FNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEE 1228
FNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEE
Sbjct: 851 FNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEE 910
Query: 1229 QGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFP 1288
QGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFP
Sbjct: 911 QGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFP 970
Query: 1289 ILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVAL 1348
ILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVAL
Sbjct: 971 ILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVAL 1030
Query: 1349 HGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKD 1408
HGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKD
Sbjct: 1031 HGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKD 1090
Query: 1409 IKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGL 1468
IKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGL
Sbjct: 1091 IKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGL 1150
Query: 1469 YSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTAR 1528
YSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTAR
Sbjct: 1151 YSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTAR 1210
Query: 1529 TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANA 1588
TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANA
Sbjct: 1211 TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANA 1270
Query: 1589 VCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIG 1648
VCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIG
Sbjct: 1271 VCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIG 1330
Query: 1649 CYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDR 1708
CYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDR
Sbjct: 1331 CYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDR 1390
Query: 1709 DDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLR 1768
DDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLR
Sbjct: 1391 DDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLR 1450
Query: 1769 NSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCLNK 1828
NSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCLNK
Sbjct: 1451 NSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCLNK 1510
Query: 1829 DSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLTGQRVENYLIS 1888
DSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLTGQRVENYLIS
Sbjct: 1511 DSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLTGQRVENYLIS 1570
Query: 1889 TANEFVQKRYGGWSFGLPLTKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFL 1948
TANEFVQKRYGGWSFGLPLTKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFL
Sbjct: 1571 TANEFVQKRYGGWSFGLPLTKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFL 1630
Query: 1949 LRVNMSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYV 2008
LRVNMSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYV
Sbjct: 1631 LRVNMSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYV 1690
Query: 2009 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLG 2068
VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLG
Sbjct: 1691 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLG 1750
Query: 2069 AVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKP 2128
AVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKP
Sbjct: 1751 AVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKP 1810
Query: 2129 NDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGA 2188
NDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGA
Sbjct: 1811 NDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGA 1870
Query: 2189 MFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGA 2248
MFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGA
Sbjct: 1871 MFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGA 1930
Query: 2249 AEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDII 2308
AEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDII
Sbjct: 1931 AEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDII 1990
Query: 2309 PSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKE 2368
PSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKE
Sbjct: 1991 PSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKE 2050
Query: 2369 TVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHL 2428
TVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHL
Sbjct: 2051 TVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHL 2110
Query: 2429 WKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKV 2488
WKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKV
Sbjct: 2111 WKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKV 2170
Query: 2489 HLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNI 2548
HLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNI
Sbjct: 2171 HLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNI 2230
Query: 2549 TNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDDQMES 2595
TNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDDQMES
Sbjct: 2231 TNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDDQMES 2277
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 1454 bits (3764), Expect = 0.0
Identities = 843/2053 (41%), Positives = 1212/2053 (59%), Gaps = 92/2053 (4%)
Query: 554 QLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAIPIPDNRAEIISQVFWLHS-CDTNI--- 609
++ ++ KN+ +L E+LR + +SN TI +L I ++ + L CD I
Sbjct: 3069 KIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGKCDQEILHL 3128
Query: 610 --TTPKLED---AMKEFCNLSLSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQKPVE 664
T PK E A +E C+L S+ Y + + L L++ F YK P + +
Sbjct: 3129 LLTFPKGEKSWIAAEELCSLPGSK----VYSLIVLLSRNLDVRAFIYKTLMPSEANGLLN 3184
Query: 665 KMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQGSFST 724
++++ L +L + L + + + K L ++ Q ++ GSF
Sbjct: 3185 SLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFGSFQF 3244
Query: 725 ISQALCSQGITTEYLTAMLPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPFCFSL 784
+ + +C + + M + R K+ L E K+ IP +STPFC L
Sbjct: 3245 VMKMVCKDQASFLSDSNMFINLPR-----VKELL------EDDKEKFNIPEDSTPFCLKL 3293
Query: 785 YKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMD 844
Y++I+ +P G ++W FLKP+L G+ILY P P +++K+N T + +L+ S+ ++
Sbjct: 3294 YQEILQLPNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLE 3353
Query: 845 KSPLFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLKLENN 904
S LF S Q LQ LRN FV+ FV+ + +D +L +++ L ++ N+
Sbjct: 3354 MSSLFQRSGS--GQMFNQLQEALRNKFVRNFVENQLHIDVDKLTEKLQTYGGLLDEMFNH 3411
Query: 905 IDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNR 964
+ L S+ VN+SSCV +R QA +++D +E +A L + N S+IF SN
Sbjct: 3412 AGA-GRFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIF---SNS 3467
Query: 965 SWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYL 1024
+ + + S +V LPP + YTIR ++ + T ++ W P N P+ Y F L
Sbjct: 3468 LFDKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPL 3527
Query: 1025 QDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAF 1084
QD IERAII +QTG+ + E A Q QA PYPC D FL +V + P+++M+ W+V +A+
Sbjct: 3528 QDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASM 3587
Query: 1085 VKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNG 1144
V+KLVYE+++++ EYM+MMGV+ HF AW +E++ L ++ L I+LK I +N
Sbjct: 3588 VRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNT 3647
Query: 1145 FILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVL 1204
FI+FL+ D+ SV+ +SYL+S FF+ N AAL SL+Y+I+F P+IVL+ + N+LS+V
Sbjct: 3648 FIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVN 3707
Query: 1205 KVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIY 1264
+ F+ LLS TAF +I E Q G+QW NMY + Q T FGW+C +IL DS +Y
Sbjct: 3708 QTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMT-FGWVCWMILFDSSLY 3766
Query: 1265 FLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPE-KSNGLMFTNIMMQNTNP 1323
FL WY+ N+ PGT+G+ PWYFP SYWK E + S+ L F N N
Sbjct: 3767 FLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGS 3826
Query: 1324 SASPEYMFSSNIEPEPKDLTVGVALHGVTKIY-GSKVAVDNLNLNFYEGHITSLLGPNGA 1382
S N E E + GV L VTK Y G K V +L+L FY IT+LLG NGA
Sbjct: 3827 SLQ-------NREGELEGSAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGA 3879
Query: 1383 GKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLY 1442
GKTT ISMLTGL ++GTI + GK+++TDL VR +GVC Q D+L LT +EHLLL+
Sbjct: 3880 GKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLF 3939
Query: 1443 GSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVIL 1502
SIK P WTKK+LH++V +TL+D L H+HK+ LSGG+KRKLS+ IA +G SR V+L
Sbjct: 3940 ASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVL 3999
Query: 1503 DEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPF 1562
DEP++GVDPCSR S+WD++ K + RTII +THHLDEAE LSDR+A L+ G LRCCG PF
Sbjct: 4000 DEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPF 4059
Query: 1563 YLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPP 1622
LKEA+G G LTLT++ S L A+ + D VT++I+ ++P+A+LK+ G EL Y +P
Sbjct: 4060 CLKEAYGQGLRLTLTRQPSV-LEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPK 4118
Query: 1623 FSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQK 1682
+ K L +ALD + L++ YGISDTT+EEVFL L ++S K S ++L T+
Sbjct: 4119 DTDKA--CLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSNKKSHIALG--TES 4174
Query: 1683 KIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRR 1742
++ N G LS + L R + G LL ++ AIL +R T R
Sbjct: 4175 ELQNHRPTG-----HLSGYCGS--------LARPATVQGVQLLRAQVAAILARRLRRTLR 4221
Query: 1743 NWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEA 1802
K +A ++LP++FV AMGL +R + YP ++++P Y +E T F+++ + +
Sbjct: 4222 AGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAE-TYFFSSGGDNLDL 4280
Query: 1803 LVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNF-GVCSCSENVQECPKFNY 1861
+ F D C +DL K+S W T F C C + CP +
Sbjct: 4281 TRVLLRKFRDQDLPC---ADLNPRQKNS-SCWRTDPFSHPEFQDSCGCLK----CPNRSA 4332
Query: 1862 SPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPAN 1921
S P+ + + NL+G +E YL++ + + R GGWSFGL + + +
Sbjct: 4333 SAPYLTNHLGHTLLNLSGFNMEEYLLAPSEK---PRLGGWSFGLKIPSEAGGANGNISKP 4389
Query: 1922 RTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSK-YDAARHGIIMYSHPYPGVQDQEQAT 1980
TLAKVWY+ +G+HSLP+YLN LNN +L ++ D ++GI +YSHPY G +
Sbjct: 4390 PTLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKI 4449
Query: 1981 ISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMV 2040
+ S+ VAL I++G+S+ +AS + VVR+ AK+LQHISG+G YW TNF+YDM+
Sbjct: 4450 LESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDML 4509
Query: 2041 FYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFI 2100
FYLV V + +I F+L AF NL A +LLL LFGYAT WMYL++ +F + +AFI
Sbjct: 4510 FYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFI 4569
Query: 2101 TYVCVNLFFGINSI---VSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLI 2157
+YV +N FG+ ++ + ++ +SK K L+ I + LK +F IFPQFC G GL+
Sbjct: 4570 SYVSLNFIFGLCTMLITIMPRLLAIISKAK----NLQNIYDVLKWVFTIFPQFCLGQGLV 4625
Query: 2158 ELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL 2217
EL Q D +G++ FEMN LG +FV L SQGT+ LR+L++ L++ R
Sbjct: 4626 ELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPR- 4684
Query: 2218 FFRKFNSSHVRETI--DEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNN 2275
S ++ T+ +D DV E RV G D++ LY L+K Y+ + IIAV +
Sbjct: 4685 -----GHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQD 4739
Query: 2276 ISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSS---L 2332
IS+GIP GECFGLLGVNGAGK+T FKML G++ +SG+ +IR G + S + L
Sbjct: 4740 ISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVL 4799
Query: 2333 VGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSY 2392
+GYCPQ+DALD+L+T EHLY+Y + GIP + I E L+RRLHL D+ + S
Sbjct: 4800 IGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSG 4859
Query: 2393 GTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEEC 2452
GTKRKLSTALAL+GKP ILLLDEPSSGMDP SKR+LW+ I +EV+ C+ +LTSHSMEEC
Sbjct: 4860 GTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEEC 4919
Query: 2453 EALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTY 2512
EALCTRLAIMVNG F+C+GS QHIK+RFG G+TVKV L T++ ++L+FP
Sbjct: 4920 EALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQ 4979
Query: 2513 LKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSY 2572
K QHL++LEYHVP G +A++F ++E NKT LNI ++ ++QTTLE+VFINFA +Q+
Sbjct: 4980 FKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQ-- 5037
Query: 2573 ETADTSSQGSTIS 2585
+T ++ ST S
Sbjct: 5038 QTLQSTLDPSTDS 5050
Score = 88.6 bits (218), Expect = 7e-17
Identities = 38/81 (46%), Positives = 53/81 (65%)
Query: 7 QLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTG 66
Q + L+WKNWL R P+ L WP I+F+IL + R + PP + CYL PR+LPS G
Sbjct: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCG 66
Query: 67 FFPFLQTLLCDTDSKCKDTPY 87
PF+Q+LLC+T S+C++ Y
Sbjct: 67 VIPFVQSLLCNTGSRCRNFSY 87
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 1179 bits (3050), Expect = 0.0
Identities = 691/1929 (35%), Positives = 1079/1929 (55%), Gaps = 189/1929 (9%)
Query: 776 NSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAEL 835
++TP+C L K++ + P +IW LKP+L+G+ILY P P T+ +M + N T ++LA
Sbjct: 350 STTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVF 409
Query: 836 REKSQEWMDKSP---LFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLD------AVE 886
+ W + SP FM + ++ +L + + F + + GLD
Sbjct: 410 HDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLD---GLDWTAQDIVAF 466
Query: 887 LLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRL 946
L K +++ + + ++ N CV ++++ T + ++ L
Sbjct: 467 LAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMEL 526
Query: 947 YKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPG 1006
+ + ++F G G++ LP +KY IRM + + T ++ W PG
Sbjct: 527 LDERKFWAGIVFT---------GITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPG 577
Query: 1007 PHNSPSHNQIY-GRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSV 1065
P P + Y F YLQD +E+AII + TG ++ V +Q +PYPC++ D FL +
Sbjct: 578 PRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTG-TEKKTGVYMQQMPYPCYVDDIFLRVM 636
Query: 1066 SYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVT 1125
S S+P+ + +AW+ +A +K +VYEK+ RL E M++MG+++ +F+W I S+ LLV+
Sbjct: 637 SRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVS 696
Query: 1126 IVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYII 1185
+L++ILK GN+LP ++ ++F++ S ++ I +LIS F+ N+AA G +IY
Sbjct: 697 AGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFT 756
Query: 1186 AFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQD 1245
+ P+++ V ++ + + LK+F SLLSP AF + +Y A +EEQGIG+QW+N++ SPV++
Sbjct: 757 LYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEE 816
Query: 1246 DTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKP 1305
D + ++L D+F+Y ++ WY+ VFPG YG+ PWYFP SYW FG E
Sbjct: 817 DGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYW---FG--EESD 871
Query: 1306 EKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDN 1363
EKS+ P ++ + + +E EP L +GV++ + K+Y G KVAVD
Sbjct: 872 EKSH-------------PGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDG 918
Query: 1364 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVC 1423
L LNFYEG ITS LG NGAGKTTT+S+LTGLF ++GT ++ GKDI++++ T+R+N+GVC
Sbjct: 919 LALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVC 978
Query: 1424 MQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHK-RVGTLSGG 1482
QH+VLF LT +EH+ Y +K ++K + E+++ D GL S + K + LSGG
Sbjct: 979 PQHNVLFDMLTVEEHIWFYARLK--GLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGG 1036
Query: 1483 MKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEV 1542
M+RKLS+++A +GGS+VVILDEP+ GVDP SRR IW+++ K + RTIILSTHH+DEA+V
Sbjct: 1037 MQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADV 1096
Query: 1543 LSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKK---------------------- 1580
L DRIA + G L C GS +LK G GY+LTL KK
Sbjct: 1097 LGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKED 1156
Query: 1581 ------------SPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVS 1628
S + + D A++ +I+ H+ EA L EDIG EL YVLP + K
Sbjct: 1157 SVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAK-E 1215
Query: 1629 GAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSN 1688
GA++ L +D+ + DL I YGIS+TT+EE+FL + +ES ++ S L ++ N
Sbjct: 1216 GAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARR--NRR 1273
Query: 1689 ANGIS-------TPDDLSVSSSNFTDRDDKILTRGERLDGFG--------LLLKKIMAIL 1733
A G T DD + + + D + + +DG G L ++ +A+L
Sbjct: 1274 AFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALL 1333
Query: 1734 IKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFY 1793
KR RR+ KG AQ++LP VFV A+ + YP +++ P +Y +EQ F
Sbjct: 1334 WKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMY--NEQYTFV 1391
Query: 1794 ANYHPS---TEALVSAMWDFPGIDNMCLNTS---DLQCLNKDSLEKWNTSGEPITNFGV- 1846
+N P T L++A+ PG C+ + D C + E+W T+ P T +
Sbjct: 1392 SNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGE--EEWTTAPVPQTIMDLF 1449
Query: 1847 -------------CSCSEN-----VQECPKF--NYSPPHRRTYSSQVIYNLTGQRVENYL 1886
C CS + + CP PP R+ ++ ++ +LTG+ + +YL
Sbjct: 1450 QNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYL 1509
Query: 1887 ISTANEFVQK-----------RYGGWSFG-----------------------LPLTKDLR 1912
+ T + + K RYGG+S G L L KD
Sbjct: 1510 VKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSS 1569
Query: 1913 FD---------ITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARH-G 1962
D +TG+ + KVW++ +G+H++ ++LN +NN +LR N+ K + H G
Sbjct: 1570 ADRFLNSLGRFMTGLDTKNNV-KVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYG 1628
Query: 1963 IIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQ 2020
I ++HP + Q E A +++ +D+LV++ ++ S ASFV ++++E +KAK LQ
Sbjct: 1629 ITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQ 1688
Query: 2021 HISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYA 2080
ISG+ YW++NF++DM Y+VP I I F+ ++ S NL ++LLLLL+G++
Sbjct: 1689 FISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWS 1748
Query: 2081 TFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETL 2140
MY + +F A++ VNLF GIN V+ V+ + K N+ I++ L
Sbjct: 1749 ITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNN-----INDIL 1803
Query: 2141 KRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMF 2200
K +FLIFP FC G GLI++ + Q++ D L+ +G + +G A+ +G +F
Sbjct: 1804 KSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVF 1863
Query: 2201 FSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLT 2260
F + +LI + R K + + DEDEDVR ER R+ G + D++++ LT
Sbjct: 1864 FLITVLIQYRFFIRPRPVNAKLSPLN-----DEDEDVRRERQRILDGGGQNDILEIKELT 1918
Query: 2261 KTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKT 2320
K Y+ K+ AV+ I +GIP GECFGLLGVNGAGK++ FKMLTGD + G+ + NK
Sbjct: 1919 KIYR--RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL-NKN 1975
Query: 2321 GSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLM 2380
L ++ +GYCPQ DA+ +L+T EH+ F+A + G+PEK++ + +R+L L+
Sbjct: 1976 SILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLV 2035
Query: 2381 PFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKC 2440
+ ++ S G KRKLSTA+ALIG P ++ LDEP++GMDPK++R LW V+
Sbjct: 2036 KYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGR 2095
Query: 2441 SVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETL 2500
SV+LTSHSMEECEALCTR+AIMVNG+F+C+GS+QH+K+RFG G+T+ V + + ++ +
Sbjct: 2096 SVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPV 2155
Query: 2501 TKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEE 2560
F L FP + LK++H +ML+Y +P + +A IF +L +K L+I ++ VSQTTL++
Sbjct: 2156 QDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQ 2215
Query: 2561 VFINFAKDQ 2569
VF+NFAKDQ
Sbjct: 2216 VFVNFAKDQ 2224
Score = 63.9 bits (154), Expect = 2e-09
Identities = 26/76 (34%), Positives = 46/76 (60%)
Query: 7 QLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTG 66
QL++L+WKN +RQ L+ + WP+ IF+IL R +PP + C+ + +PS G
Sbjct: 6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG 65
Query: 67 FFPFLQTLLCDTDSKC 82
P++Q ++C+ ++ C
Sbjct: 66 TLPWVQGIICNANNPC 81
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 1119 bits (2894), Expect = 0.0
Identities = 678/1970 (34%), Positives = 1068/1970 (54%), Gaps = 170/1970 (8%)
Query: 752 NHTKDFLTYKLTKEQIASKYGIPINSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGRILY 811
N+ K FL T++ Y +T FC +L + + + P + W KP+L+G+ILY
Sbjct: 343 NNYKAFLGIDSTRKDPI--YSYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILY 400
Query: 812 APYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLRNPF 871
P +P + I++ +N T +L +R+ + W + P F Q + M+++TL NP
Sbjct: 401 TPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQ-MNMIRDTLGNPT 459
Query: 872 VQVFVKFSVGLDAVE-------LLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSC 924
V+ F+ +G + + L K E + + DI + + L C
Sbjct: 460 VKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWRDIFNITDRTLRLVNQYLEC 519
Query: 925 VLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYT 984
++ D+ ++ ++ + A L + N + V+F P W LPP +KY
Sbjct: 520 LVLDKFESYNDETQLTQRALSLLEENMFWAGVVF--PDMYPWTSS-------LPPHVKYK 570
Query: 985 IRMSLKTAQTTRSLRTKIWAPGPHNSPSHN--QIYGRAFIYLQDSIERAIIELQTGRNSQ 1042
IRM + + T ++ + W GP P + I+G F YLQD +E+ I Q +
Sbjct: 571 IRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWG-GFAYLQDMVEQGITRSQVQAEAP 629
Query: 1043 EIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKM 1102
+ + +Q +PYPCF+ D+F+ ++ PI +++AW+ ++ VK +V EK+LRL E +K
Sbjct: 630 -VGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLKN 688
Query: 1103 MGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMS 1162
GV++ + W ++S + ++I +L I + G IL ++ FILFL+ +S + I +
Sbjct: 689 QGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLC 748
Query: 1163 YLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQY 1222
+L+S FF+ ++AA +IY + P I+ ++ ++ LK +SLLSP AF + ++Y
Sbjct: 749 FLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEY 808
Query: 1223 IARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMA 1282
+ R+EEQG+GLQW N+ SP + D SF ++L D+ +Y L+AWY+ VFPG YG
Sbjct: 809 LVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTP 868
Query: 1283 APWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDL 1342
PWYF + SYW GC+ + L T + + T PE + S E E
Sbjct: 869 LPWYFLLQESYWLGGEGCS---TREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGW 925
Query: 1343 TVGVALHGVTKIYG--SKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAG 1400
GV + + KI+ + AVD LN+ FYE IT+ LG NGAGKTTT+S+LTGL ++G
Sbjct: 926 VPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSG 985
Query: 1401 TIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVK 1460
T+ V G+DI+T L VR+++G+C QH++LF +LT EH+L Y +K + QL E++
Sbjct: 986 TVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQL--EME 1043
Query: 1461 RTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDV 1520
L+DTGL+ R++ LSGGM+RKLS++IA +G ++VVILDEP++GVDP SRRSIWD+
Sbjct: 1044 AMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDL 1103
Query: 1521 ISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKK- 1579
+ K ++ RTII+STHH+DEA++L DRIA + QG L C G+P +LK FG G +LTL +K
Sbjct: 1104 LLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKM 1163
Query: 1580 ---KSPNLNANAVC--------------------------DTMAVTAMIQSHLPEAYLKE 1610
+S + C D + ++ H+PEA L E
Sbjct: 1164 KNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVE 1223
Query: 1611 DIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQK 1670
IG EL+++LP + K AY SL R L+ + DL + +GISDT +EE+FL +T++S
Sbjct: 1224 CIGQELIFLLPNKNFK-HRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDS-- 1280
Query: 1671 NSAMSLEHLTQKKIGNSN---------ANGISTPDDLSVSSSNFT------DRDDKILTR 1715
+S Q+K N N TP D +V S +
Sbjct: 1281 DSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECP 1340
Query: 1716 GERLD-GFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSY 1774
G +L+ G L+L+ + A+L+KRF HT R+ K +AQ++LP FV A+ L + Y
Sbjct: 1341 GPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEY 1400
Query: 1775 PEIQISPSLYGTSEQTAFYANYHPSTE---ALVSAMWDFPGIDNMCLNTSDLQCLNKDSL 1831
P + + P +YG +Q F++ P +E L + + PG N CL L +
Sbjct: 1401 PALTLHPWIYG--QQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNS 1458
Query: 1832 EKWNTSG--------------EPITNFGVCSCSEN-----VQECPK--FNYSPPHRRTYS 1870
W T + C CS + ECP+ PP R S
Sbjct: 1459 TPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRS 1518
Query: 1871 SQVIYNLTGQRVENYLISTANEFV-----------QKRYGGWSFG-----LPLTKDLR-- 1912
++++ +LT + + ++L+ T + ++RYGG S G +P+T +
Sbjct: 1519 TEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVG 1578
Query: 1913 --------FDITGVPANRTLA----------------KVWYDPEGYHSLPAYLNSLNNFL 1948
+++G P R + KVW++ +G+H+L ++LN +N +
Sbjct: 1579 FLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAI 1638
Query: 1949 LRVNMSK-YDAARHGIIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFV 2005
LR ++ K +GI + S P ++Q E +++ +D +VA+ ++ S ASFV
Sbjct: 1639 LRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFV 1698
Query: 2006 TYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSEN 2065
Y+++E K+K LQ ISG+ T YWVTNF++D++ Y V +GI F+ A+ S
Sbjct: 1699 LYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPE 1758
Query: 2066 NLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSK 2125
NL A+ LLLL+G+A MY + LF A++ C NLF GINS S + F+ +
Sbjct: 1759 NLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINS----SAITFILE 1814
Query: 2126 EKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNK 2185
N+ TL + L+++ ++FP FC G GLI+L+ Q+V D +G E+ F +
Sbjct: 1815 LFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDL 1874
Query: 2186 LGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETI-DEDEDVRAERLRV 2244
+G A+V +G ++F L LL+ F ++ + +E I DED+DV ER R+
Sbjct: 1875 IGKNLFAMVVEGVVYFLLTLLVQR------HFFLSQWIAEPTKEPIVDEDDDVAEERQRI 1928
Query: 2245 ESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLT 2304
+G + D+++L+ LTK Y AV+ + +G+ GECFGLLGVNGAGKTT FKMLT
Sbjct: 1929 ITGGNKTDILRLHELTKIYPGTSSP--AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLT 1986
Query: 2305 GDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEK 2364
GD +SG+ + K+ + H ++ GYCPQ DA+D+L+T EHLY YAR+ G+P +
Sbjct: 1987 GDTTVTSGDATVAGKSILTNISEVHQNM-GYCPQFDAIDELLTGREHLYLYARLRGVPAE 2045
Query: 2365 DIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKS 2424
+I++ + ++ L L + D S G KRKLSTA+ALIG P ++LLDEP++GMDP++
Sbjct: 2046 EIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQA 2105
Query: 2425 KRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGF 2484
+R LW +I ++ +V+LTSHSMEECEALCTRLAIMV G F+C+G++QH+KS+FG G+
Sbjct: 2106 RRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGY 2165
Query: 2485 TVKVHLKNNK----VTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLE 2540
V + +K+ K + + +F Q +FP + +++H +ML++ V++ +A IF LL
Sbjct: 2166 IVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQ--VSSSSLARIFQLLL 2223
Query: 2541 TNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQD 2590
++K +L I + V+QTTL++VF+NFAK Q + + S +QD
Sbjct: 2224 SHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD 2273
Score = 65.5 bits (158), Expect = 7e-10
Identities = 27/80 (33%), Positives = 48/80 (60%)
Query: 7 QLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTG 66
Q+Q+L+WKNW KRQ + +V ++WP+ +F++L R P + C+ + +PS G
Sbjct: 6 QIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAG 65
Query: 67 FFPFLQTLLCDTDSKCKDTP 86
P+LQ + C+ ++ C +P
Sbjct: 66 MLPWLQGIFCNVNNPCFQSP 85
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 1021 bits (2640), Expect = 0.0
Identities = 685/2015 (33%), Positives = 1060/2015 (52%), Gaps = 185/2015 (9%)
Query: 677 LNQMASGTHPLLDKMRSLKQMHLP-RSVPLTQAMYRSNRMNTPQGSFSTISQALCSQGIT 735
L Q H LL+ L Q L RS+ +A+ + R + G +S+ALCS
Sbjct: 173 LGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTS--GPLELLSEALCS---- 226
Query: 736 TEYLTAMLPSSQ-RPKGNHTKDFLTYKLTKEQIASKYGIPINS-TPFCFSLYKDIINMPA 793
PSS P N + +L ++ S +P +S +P C L + + P
Sbjct: 227 -----VRGPSSTVGPSLNWYEASDLMELVGQEPES--ALPDSSLSPACSELIGALDSHPL 279
Query: 794 GPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSP---LFM 850
++W LKP++LG++L+AP P T+ +M + N T +L LR+ + W P FM
Sbjct: 280 SRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFM 339
Query: 851 NSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLKLEN-NIDIID 909
N + + MLQ L+ G D +E L+ + ++ + D+
Sbjct: 340 ND----SSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGH 395
Query: 910 QLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRS---W 966
+ TL +T C+ D+++AA + + A +L + + V+F P + S
Sbjct: 396 LVGTLGRVT----ECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTE 451
Query: 967 HRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIY-GRAFIYLQ 1025
H D G P ++ IRM + T +R + W PGP P + Y F+YLQ
Sbjct: 452 HPTPDLG----PGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQ 507
Query: 1026 DSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFV 1085
D +ERA + + +G N + + +Q +PYPC++ D FL +S SLP+ L +AW+ + V
Sbjct: 508 DLVERAAVRVLSGANPRA-GLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTV 566
Query: 1086 KKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGF 1145
K +V EK+ RL + M+ MG++ + W + +G L++ +L+++LK G+ILP ++
Sbjct: 567 KAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPG 626
Query: 1146 ILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLK 1205
++FL+ + ++ + + S+L+S FF+ N+AA G L Y + P+++ V + L +
Sbjct: 627 VVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGR 686
Query: 1206 VFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYF 1265
V SLLSP AF + + +A EEQG G QW N+ T P D S + L+L D+ +Y
Sbjct: 687 VAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTAD-VFSLAQVSGLLLLDAALYG 745
Query: 1266 LIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSA 1325
L WY+ V PG YG+ PW FP SYW C +P KS T +
Sbjct: 746 LATWYLEAVCPGQYGIPEPWNFPFRRSYW-----CGP-RPPKSPAPCPTPL--------- 790
Query: 1326 SPEYMFSSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDNLNLNFYEGHITSLLGPNGAG 1383
P+ + +E P L+ GV++ + K + + A+ L+L+FY+GHIT+ LG NGAG
Sbjct: 791 DPKVL----VEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAG 846
Query: 1384 KTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYG 1443
KTTT+S+L+GLF S G+ F+ G D+++ + +R ++GVC Q++VLF LT EH+ YG
Sbjct: 847 KTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYG 906
Query: 1444 SIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILD 1503
+K + + E R L+D GL S + + LSGGM+RKLS++IA +GGS+VVILD
Sbjct: 907 RLK--GLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILD 964
Query: 1504 EPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFY 1563
EP+ GVDP SRR IW+++ K + RT+ILSTHHLDEAE+L DR+A + G L CCGSP +
Sbjct: 965 EPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLF 1024
Query: 1564 LKEAFGDGYHLTLTKKKSPNLNANAVCDT-----------------------MAVTAMIQ 1600
L+ G GY+LTL K + P L N DT + A++Q
Sbjct: 1025 LRRHLGSGYYLTLVKARLP-LTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQ 1083
Query: 1601 SHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEV 1660
+P A L E++ ELV VLP ++ G++ +L R LD + +L + YGISDT++EE+
Sbjct: 1084 HWVPGARLVEELPHELVLVLP-YTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEI 1142
Query: 1661 FLNLTKESQKNSAMSL----EHLTQKKIGNSNANGISTPDDLSV-------SSSNFTDRD 1709
FL + +E ++ M +HL G + P + S+ TD+
Sbjct: 1143 FLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQG 1202
Query: 1710 DKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRN 1769
G R+ G+ L +++ A+L+KRF RR+ +GL AQ++LP +FV A+ +
Sbjct: 1203 SGPDAVG-RVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVP 1261
Query: 1770 SSNSYPEIQISPSLYGTSEQTAFY---ANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCL 1826
YP +++SP++YG Q +F+ A P L+ A+ G++ + S +
Sbjct: 1262 PFGHYPALRLSPTMYGA--QVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFS 1319
Query: 1827 NKD---SLEKWNTSGE--PITNFGVCSCSEN-----VQECPKFNYSPPHRR--TYSSQVI 1874
+ + K SG P + C CS + +CP PP + T S +V+
Sbjct: 1320 APEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVV 1379
Query: 1875 YNLTGQRVENYLISTANEFVQK-----------RYGGWSFG-----LPLTKDLRFDIT-- 1916
NLTG+ + ++L+ T V++ RYGG+S G LP ++L +
Sbjct: 1380 QNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEEL 1439
Query: 1917 --------GVPANRTLA---------------KVWYDPEGYHSLPAYLNSLNNFLLRVNM 1953
G +R L K+W++ +G+HS+ A++N +N +LR ++
Sbjct: 1440 WALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHL 1499
Query: 1954 SKYDAAR-HGIIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFVTYVVR 2010
A H I +HP ++Q E A ++S +D+LV++ ++ S ASF ++
Sbjct: 1500 PPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIE 1559
Query: 2011 EHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAV 2070
E T+AK LQ + G+ T YW+ NF++DM YLVP + I F+ A+ + NL A+
Sbjct: 1560 ERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPAL 1619
Query: 2071 SLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPND 2130
LLLLL+G++ MY + F A++ C+NLF GIN ++ V+ S +K
Sbjct: 1620 LLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQK--- 1676
Query: 2131 PTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMF 2190
L+ +S LK++FLIFP FC G GLI++ + Q++ D + G +G
Sbjct: 1677 --LQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNL 1734
Query: 2191 VALVSQGTMF--FSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGA 2248
+A+V QG +F F+L L L+ + R+ +EDEDV ER RV GA
Sbjct: 1735 LAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLG-------EEDEDVARERERVVQGA 1787
Query: 2249 AEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDII 2308
+ D++ L LTK Y+ +++ AV+ + +GIP GECFGLLGVNGAGKT+ F+M+TGD +
Sbjct: 1788 TQGDVLVLRNLTKVYR--GQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTL 1845
Query: 2309 PSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKE 2368
S G ++ + + +H S+ GYCPQ DA+ +L+T EHL AR+ G+PE + +
Sbjct: 1846 ASRGEAVLAGHSVAREPSAAHLSM-GYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQ 1904
Query: 2369 TVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHL 2428
T L RL L + DR S G KRKL+TALAL+G P+++ LDEP++GMDP ++R L
Sbjct: 1905 TAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFL 1964
Query: 2429 WKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKV 2488
W + V+ SV+LTSHSMEECEALC+RLAIMVNG+F+C+GS QH+K RF G T+
Sbjct: 1965 WNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLT- 2023
Query: 2489 HLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGG---VANIFDLLETNKTA 2545
L+ + F+ FP L++ H L + +P GG +A +F L +
Sbjct: 2024 -LRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLP--PGGRCALARVFGELAVHGAE 2080
Query: 2546 LNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQ 2580
+ +F VSQT LEEVF+ F+KDQ E DT Q
Sbjct: 2081 HGVEDFSVSQTMLEEVFLYFSKDQGKDE--DTEEQ 2113
Score = 71.6 bits (174), Expect = 9e-12
Identities = 31/76 (40%), Positives = 47/76 (61%)
Query: 7 QLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTG 66
QL +L+WKN++ +RQP+ LV +LWP+ +F IL R PP C+ + LPS G
Sbjct: 6 QLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAG 65
Query: 67 FFPFLQTLLCDTDSKC 82
P+LQ L+C+ ++ C
Sbjct: 66 TVPWLQGLICNVNNTC 81
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 1018 bits (2631), Expect = 0.0
Identities = 647/1949 (33%), Positives = 1015/1949 (52%), Gaps = 229/1949 (11%)
Query: 808 RILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTL 867
+ILYAP ++ K+N T + + +Q W++ S + L Q LQ L
Sbjct: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRS---FLEQG--RLQQHL 513
Query: 868 RNPFVQVFVKFSVGLDAVELLKQIDELD-ILR---LKLENNIDIIDQLNTLSSLTVNISS 923
R ++Q +V + L L +DEL LR L + + ++ QL+T+ +
Sbjct: 514 R--WLQQYVA-ELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQ 570
Query: 924 CVLYDRIQAAKTIDEMER----EAKRLYKSN-ELFGSVIFKLPSNRSWHRGYDSGNVFLP 978
+ + K + E + Y+ N +F SVIF+ + S LP
Sbjct: 571 FMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGS-----------LP 619
Query: 979 PVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTG 1038
P + Y IR + + T +R W PGP+ +YG F+++QD +ERAII+ G
Sbjct: 620 PHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYG--FVWIQDMMERAIIDTFVG 677
Query: 1039 RNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHE 1098
+ E VQ PYPC+ +D+FL + + +P+ ++++WV +A ++ +V EK+ RL E
Sbjct: 678 HDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKE 737
Query: 1099 YMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSV 1158
MK MG+N+ H+ AW I L +++ L ILK+G +L ++ I++L+ + Y+ +
Sbjct: 738 VMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVAT 797
Query: 1159 IAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVE----NELSYVLKVFMSLLSPT 1214
I +L+SV ++ +A+ G +IY +++ P++ + E ++++ K SL+S T
Sbjct: 798 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTT 857
Query: 1215 AFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNV 1274
AF S+Y A YE G+G+QW SPV+ D + +++ D+ +Y ++ WY+ V
Sbjct: 858 AFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAV 917
Query: 1275 FPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPE---YMF 1331
PG YG+ PWYFP+ SYW G E + + + + + E +
Sbjct: 918 HPGMYGLPRPWYFPLQKSYWLGS-GRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEE 976
Query: 1332 SSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTIS 1389
+ +E EP L + V + +TK+Y K+A++ L+LN YE + S LG NGAGKTTT+S
Sbjct: 977 TRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMS 1036
Query: 1390 MLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH 1449
+LTGLF ++G+ +YG DI+T++ +RKN+G+C QH+VLF LT +EHL Y +K
Sbjct: 1037 ILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLK--S 1094
Query: 1450 WTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGV 1509
++++ E+ + ++D L + RH V TLSGGMKRKLS++IA +GGSR +ILDEP+ GV
Sbjct: 1095 MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGV 1154
Query: 1510 DPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFG 1569
DP +RR+IWD+I K K RTI+LSTHH+DEA++L DRIA + G L+CCGSP +LK +G
Sbjct: 1155 DPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYG 1214
Query: 1570 DGYHLTLTKK-------KSPNLNAN-------AVCDTMAVTAMIQSHLPEAYLKEDIGGE 1615
DGY LTL K+ + P L ++ + C + V+ I+ H+ L D E
Sbjct: 1215 DGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTE 1274
Query: 1616 LVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQ--KNSA 1673
L Y+LP + K GA+ L + L+ + L++ +G+ DTT+EEVFL +++E Q +NS
Sbjct: 1275 LSYILPSEAAK-KGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSE 1333
Query: 1674 MSLE---------------------------HLTQKKIGNSNANGIST------------ 1694
++ LTQ + +A+ + +
Sbjct: 1334 ADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDV 1393
Query: 1695 -------------PDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTR 1741
PD++S+ + ++ +LDG L +++ +L+KRFH R
Sbjct: 1394 YGDYRPLFDNPQDPDNVSLQEVE-AEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCAR 1452
Query: 1742 RNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAF----YANYH 1797
RN K L +Q++LP FV AM + P + +SPS Y Q YAN
Sbjct: 1453 RNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEE 1512
Query: 1798 -----------PSTEALVSAMWDFPGI--------------------------------- 1813
S + LVS G+
Sbjct: 1513 RREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFF 1572
Query: 1814 DNMCLNT-------------------SDLQCLNKDSLEKWNTSGEPITNFGV-------- 1846
D+MCL + SD + L+ WN S P +
Sbjct: 1573 DSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLP 1632
Query: 1847 --------CSCSENVQ--ECP-KFNYSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQ 1895
C+CS CP PP R + ++ ++TG V YL+ T++ F
Sbjct: 1633 RLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRL 1692
Query: 1896 KRYGGWSFGLPLTKDLRFDITGVP------ANRTLAKVWYDPEGYHSLPAYLNSLNNFLL 1949
RYG +FG L T P A R A+V+Y+ +GYHS+P YLNSLNN +L
Sbjct: 1693 HRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAIL 1752
Query: 1950 RVNM--SKYDAARHGIIMYSHPYPGVQDQEQATIS-----SLIDILVALSILMGYSVTTA 2002
R N+ SK + A +GI + +HP ++ A++S D+++A+ I++ S A
Sbjct: 1753 RANLPKSKGNPAAYGITVTNHP----MNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPA 1808
Query: 2003 SFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFY 2062
SFV ++V E TKAK LQ +SG YW+ N+++DM+ YLVP + I+ +F LPA+
Sbjct: 1809 SFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYT 1868
Query: 2063 SENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYF 2122
S N AV L LL+G++ MY + F A++ + +NLF GI + +V F
Sbjct: 1869 SPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITA----TVATF 1924
Query: 2123 LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYG-VEYPNETF 2181
L + +D L++++ LK FLIFP + G+GL+E++ + + ++ G + F
Sbjct: 1925 LLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPF 1984
Query: 2182 EMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAER 2241
E + + VA+ +G + F L ++ + ++ R + +++D DV +ER
Sbjct: 1985 EWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLR------RPQRMPVSTKPVEDDVDVASER 2038
Query: 2242 LRVESGAAEFDLVQLYCLTKTYQLIH-KKIIAVNNISIGIPAGECFGLLGVNGAGKTTIF 2300
RV G A+ D+V++ LTK Y+ +I+AV+ + +G+ GECFGLLGVNGAGKT+ F
Sbjct: 2039 QRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTF 2098
Query: 2301 KMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHG 2360
KMLTGD + G + N L + +GYCPQ DAL D +T EHL Y R+ G
Sbjct: 2099 KMLTGDESTTGGEAFV-NGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRG 2157
Query: 2361 IPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGM 2420
I KD V L +L L + D+ S G KRKLSTA+ALIG P+ + LDEP++GM
Sbjct: 2158 ISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGM 2217
Query: 2421 DPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2480
DPK++R LW +I + ++ SV+LTSHSMEECEALCTRLAIMVNG+ +C+GS+QH+K+RF
Sbjct: 2218 DPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRF 2277
Query: 2481 GRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLE 2540
G G+ + V K+++ +++ + +F +FP+ LK++H + ++Y + +A +F +E
Sbjct: 2278 GDGYMITVRTKSSQ-SVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKME 2336
Query: 2541 TNKTALNITNFLVSQTTLEEVFINFAKDQ 2569
L I ++ VSQTTL+ VF+NFAK Q
Sbjct: 2337 QVSGVLGIEDYSVSQTTLDNVFVNFAKKQ 2365
Score = 200 bits (509), Expect = 1e-50
Identities = 127/332 (38%), Positives = 180/332 (54%), Gaps = 20/332 (6%)
Query: 1346 VALHGVTKIYGSK-----VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAG 1400
V + +TK+Y S+ +AVD L L G LLG NGAGKT+T MLTG + G
Sbjct: 2051 VKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGG 2110
Query: 1401 TIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVK 1460
FV G + +L V++++G C Q D LF LT +EHL LY ++ W K VK
Sbjct: 2111 EAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW--KDEARVVK 2168
Query: 1461 RTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWD- 1519
L+ L + K GT SGG KRKLS +IALIG + LDEP+TG+DP +RR +W+
Sbjct: 2169 WALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNL 2228
Query: 1520 VISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKK 1579
++ KT R+++L++H ++E E L R+A + G LRC GS +LK FGDGY +T+ K
Sbjct: 2229 ILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK 2288
Query: 1580 KSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALD 1639
S ++ V + PEA LKE ++ Y L S +S A + ++
Sbjct: 2289 SSQSVK--------DVVRFFNRNFPEAMLKERHHTKVQYQLK--SEHISLA--QVFSKME 2336
Query: 1640 NGMGDLNIGCYGISDTTVEEVFLNLTKESQKN 1671
G L I Y +S TT++ VF+N K+ N
Sbjct: 2337 QVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2368
Score = 168 bits (426), Expect = 6e-41
Identities = 106/353 (30%), Positives = 186/353 (52%), Gaps = 38/353 (10%)
Query: 2259 LTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN 2318
LTK Y+ K +A+N +S+ + + LG NGAGKTT +LTG P+SG+ I
Sbjct: 996 LTKVYK--DDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATI-- 1051
Query: 2319 KTGSLGH-----VDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKL 2373
GH +D +G CPQ + L D +TVEEHL+FY+R+ + +++I+ + K+
Sbjct: 1052 ----YGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKM 1107
Query: 2374 LRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIIS 2433
+ L L + S G KRKLS A+A +G ++LDEP++G+DP ++R +W +I
Sbjct: 1108 IEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLIL 1167
Query: 2434 EEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKN- 2492
+ + +++L++H M+E + L R+AI+ +GK +C GS +K +G G+ + + +
Sbjct: 1168 KYKPGR-TILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPA 1226
Query: 2493 --------------------NKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTA--- 2529
+ + +++F++ H L + L Y +P A
Sbjct: 1227 EPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKK 1286
Query: 2530 GGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGS 2582
G +F LE + AL++++F + TTLEEVF+ +++ +S E ++ + S
Sbjct: 1287 GAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKES 1339
Score = 45.4 bits (106), Expect = 7e-04
Identities = 28/74 (37%), Positives = 40/74 (54%), Gaps = 3/74 (4%)
Query: 6 HQLQILVWKNWLGVKRQPLWTLVL-ILWPVIIFIILAITRTKFPP-TAKPTCYLAPRNLP 63
HQLQ+L+WKN + +KR+ W L I P+++F IL R K P + K + L
Sbjct: 5 HQLQLLLWKN-VTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLT 63
Query: 64 STGFFPFLQTLLCD 77
S G P +Q+L D
Sbjct: 64 SAGILPVMQSLCPD 77
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 1018 bits (2631), Expect = 0.0
Identities = 647/1949 (33%), Positives = 1015/1949 (52%), Gaps = 229/1949 (11%)
Query: 808 RILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTL 867
+ILYAP ++ K+N T + + +Q W++ S + L Q LQ L
Sbjct: 489 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRS---FLEQG--RLQQHL 543
Query: 868 RNPFVQVFVKFSVGLDAVELLKQIDELD-ILR---LKLENNIDIIDQLNTLSSLTVNISS 923
R ++Q +V + L L +DEL LR L + + ++ QL+T+ +
Sbjct: 544 R--WLQQYVA-ELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQ 600
Query: 924 CVLYDRIQAAKTIDEMER----EAKRLYKSN-ELFGSVIFKLPSNRSWHRGYDSGNVFLP 978
+ + K + E + Y+ N +F SVIF+ + S LP
Sbjct: 601 FMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGS-----------LP 649
Query: 979 PVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTG 1038
P + Y IR + + T +R W PGP+ +YG F+++QD +ERAII+ G
Sbjct: 650 PHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYG--FVWIQDMMERAIIDTFVG 707
Query: 1039 RNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHE 1098
+ E VQ PYPC+ +D+FL + + +P+ ++++WV +A ++ +V EK+ RL E
Sbjct: 708 HDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKE 767
Query: 1099 YMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSV 1158
MK MG+N+ H+ AW I L +++ L ILK+G +L ++ I++L+ + Y+ +
Sbjct: 768 VMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVAT 827
Query: 1159 IAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVE----NELSYVLKVFMSLLSPT 1214
I +L+SV ++ +A+ G +IY +++ P++ + E ++++ K SL+S T
Sbjct: 828 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTT 887
Query: 1215 AFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNV 1274
AF S+Y A YE G+G+QW SPV+ D + +++ D+ +Y ++ WY+ V
Sbjct: 888 AFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAV 947
Query: 1275 FPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPE---YMF 1331
PG YG+ PWYFP+ SYW G E + + + + + E +
Sbjct: 948 HPGMYGLPRPWYFPLQKSYWLGS-GRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEE 1006
Query: 1332 SSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTIS 1389
+ +E EP L + V + +TK+Y K+A++ L+LN YE + S LG NGAGKTTT+S
Sbjct: 1007 TRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMS 1066
Query: 1390 MLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH 1449
+LTGLF ++G+ +YG DI+T++ +RKN+G+C QH+VLF LT +EHL Y +K
Sbjct: 1067 ILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLK--S 1124
Query: 1450 WTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGV 1509
++++ E+ + ++D L + RH V TLSGGMKRKLS++IA +GGSR +ILDEP+ GV
Sbjct: 1125 MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGV 1184
Query: 1510 DPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFG 1569
DP +RR+IWD+I K K RTI+LSTHH+DEA++L DRIA + G L+CCGSP +LK +G
Sbjct: 1185 DPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYG 1244
Query: 1570 DGYHLTLTKK-------KSPNLNAN-------AVCDTMAVTAMIQSHLPEAYLKEDIGGE 1615
DGY LTL K+ + P L ++ + C + V+ I+ H+ L D E
Sbjct: 1245 DGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTE 1304
Query: 1616 LVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQ--KNSA 1673
L Y+LP + K GA+ L + L+ + L++ +G+ DTT+EEVFL +++E Q +NS
Sbjct: 1305 LSYILPSEAAK-KGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSE 1363
Query: 1674 MSLE---------------------------HLTQKKIGNSNANGIST------------ 1694
++ LTQ + +A+ + +
Sbjct: 1364 ADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDV 1423
Query: 1695 -------------PDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTR 1741
PD++S+ + ++ +LDG L +++ +L+KRFH R
Sbjct: 1424 YGDYRPLFDNPQDPDNVSLQEVE-AEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCAR 1482
Query: 1742 RNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAF----YANYH 1797
RN K L +Q++LP FV AM + P + +SPS Y Q YAN
Sbjct: 1483 RNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEE 1542
Query: 1798 -----------PSTEALVSAMWDFPGI--------------------------------- 1813
S + LVS G+
Sbjct: 1543 RREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFF 1602
Query: 1814 DNMCLNT-------------------SDLQCLNKDSLEKWNTSGEPITNFGV-------- 1846
D+MCL + SD + L+ WN S P +
Sbjct: 1603 DSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLP 1662
Query: 1847 --------CSCSENVQ--ECP-KFNYSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQ 1895
C+CS CP PP R + ++ ++TG V YL+ T++ F
Sbjct: 1663 RLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRL 1722
Query: 1896 KRYGGWSFGLPLTKDLRFDITGVP------ANRTLAKVWYDPEGYHSLPAYLNSLNNFLL 1949
RYG +FG L T P A R A+V+Y+ +GYHS+P YLNSLNN +L
Sbjct: 1723 HRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAIL 1782
Query: 1950 RVNM--SKYDAARHGIIMYSHPYPGVQDQEQATIS-----SLIDILVALSILMGYSVTTA 2002
R N+ SK + A +GI + +HP ++ A++S D+++A+ I++ S A
Sbjct: 1783 RANLPKSKGNPAAYGITVTNHP----MNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPA 1838
Query: 2003 SFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFY 2062
SFV ++V E TKAK LQ +SG YW+ N+++DM+ YLVP + I+ +F LPA+
Sbjct: 1839 SFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYT 1898
Query: 2063 SENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYF 2122
S N AV L LL+G++ MY + F A++ + +NLF GI + +V F
Sbjct: 1899 SPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITA----TVATF 1954
Query: 2123 LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYG-VEYPNETF 2181
L + +D L++++ LK FLIFP + G+GL+E++ + + ++ G + F
Sbjct: 1955 LLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPF 2014
Query: 2182 EMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAER 2241
E + + VA+ +G + F L ++ + ++ R + +++D DV +ER
Sbjct: 2015 EWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLR------RPQRMPVSTKPVEDDVDVASER 2068
Query: 2242 LRVESGAAEFDLVQLYCLTKTYQLIH-KKIIAVNNISIGIPAGECFGLLGVNGAGKTTIF 2300
RV G A+ D+V++ LTK Y+ +I+AV+ + +G+ GECFGLLGVNGAGKT+ F
Sbjct: 2069 QRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTF 2128
Query: 2301 KMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHG 2360
KMLTGD + G + N L + +GYCPQ DAL D +T EHL Y R+ G
Sbjct: 2129 KMLTGDESTTGGEAFV-NGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRG 2187
Query: 2361 IPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGM 2420
I KD V L +L L + D+ S G KRKLSTA+ALIG P+ + LDEP++GM
Sbjct: 2188 ISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGM 2247
Query: 2421 DPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2480
DPK++R LW +I + ++ SV+LTSHSMEECEALCTRLAIMVNG+ +C+GS+QH+K+RF
Sbjct: 2248 DPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRF 2307
Query: 2481 GRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLE 2540
G G+ + V K+++ +++ + +F +FP+ LK++H + ++Y + +A +F +E
Sbjct: 2308 GDGYMITVRTKSSQ-SVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKME 2366
Query: 2541 TNKTALNITNFLVSQTTLEEVFINFAKDQ 2569
L I ++ VSQTTL+ VF+NFAK Q
Sbjct: 2367 QVSGVLGIEDYSVSQTTLDNVFVNFAKKQ 2395
Score = 200 bits (509), Expect = 1e-50
Identities = 127/332 (38%), Positives = 180/332 (54%), Gaps = 20/332 (6%)
Query: 1346 VALHGVTKIYGSK-----VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAG 1400
V + +TK+Y S+ +AVD L L G LLG NGAGKT+T MLTG + G
Sbjct: 2081 VKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGG 2140
Query: 1401 TIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVK 1460
FV G + +L V++++G C Q D LF LT +EHL LY ++ W K VK
Sbjct: 2141 EAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW--KDEARVVK 2198
Query: 1461 RTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWD- 1519
L+ L + K GT SGG KRKLS +IALIG + LDEP+TG+DP +RR +W+
Sbjct: 2199 WALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNL 2258
Query: 1520 VISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKK 1579
++ KT R+++L++H ++E E L R+A + G LRC GS +LK FGDGY +T+ K
Sbjct: 2259 ILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK 2318
Query: 1580 KSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALD 1639
S ++ V + PEA LKE ++ Y L S +S A + ++
Sbjct: 2319 SSQSVK--------DVVRFFNRNFPEAMLKERHHTKVQYQLK--SEHISLA--QVFSKME 2366
Query: 1640 NGMGDLNIGCYGISDTTVEEVFLNLTKESQKN 1671
G L I Y +S TT++ VF+N K+ N
Sbjct: 2367 QVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2398
Score = 168 bits (426), Expect = 6e-41
Identities = 106/353 (30%), Positives = 186/353 (52%), Gaps = 38/353 (10%)
Query: 2259 LTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN 2318
LTK Y+ K +A+N +S+ + + LG NGAGKTT +LTG P+SG+ I
Sbjct: 1026 LTKVYK--DDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATI-- 1081
Query: 2319 KTGSLGH-----VDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKL 2373
GH +D +G CPQ + L D +TVEEHL+FY+R+ + +++I+ + K+
Sbjct: 1082 ----YGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKM 1137
Query: 2374 LRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIIS 2433
+ L L + S G KRKLS A+A +G ++LDEP++G+DP ++R +W +I
Sbjct: 1138 IEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLIL 1197
Query: 2434 EEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKN- 2492
+ + +++L++H M+E + L R+AI+ +GK +C GS +K +G G+ + + +
Sbjct: 1198 KYKPGR-TILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPA 1256
Query: 2493 --------------------NKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTA--- 2529
+ + +++F++ H L + L Y +P A
Sbjct: 1257 EPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKK 1316
Query: 2530 GGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGS 2582
G +F LE + AL++++F + TTLEEVF+ +++ +S E ++ + S
Sbjct: 1317 GAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKES 1369
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 476 bits (1225), Expect = e-133
Identities = 292/858 (34%), Positives = 469/858 (54%), Gaps = 86/858 (10%)
Query: 949 SNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMS---------------LKTAQ 993
S+ + +V+F+ P N S LP +KY +R S LK +
Sbjct: 126 SSSVLAAVVFEHPFNHSKEP--------LPLAVKYHLRFSYTRRNYMWTQTGSFFLKETE 177
Query: 994 T--TRSLRTKIWAPGPHN--SPSHNQ--IYGRAFIYLQDSIERAIIELQ----TGRNSQE 1043
T SL PGP SP + F+ +Q +++RAI+E T + Q
Sbjct: 178 GWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQR 237
Query: 1044 IAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMM 1103
+ V ++ PYP F+ D FL ++ Y LP++L++++ + +V EK+ RL EYM+MM
Sbjct: 238 LTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMM 297
Query: 1104 GVNSCSHFFAWLIESVGFLLV-----TIVILIIILKFGNILPKTNGFILFLYFSDYSFSV 1158
G++S H+ AW + FLL+ T++ + + +L +++ ++ + ++ S
Sbjct: 298 GLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAIST 357
Query: 1159 IAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSY 1218
I+ S+++S FF+ N+AA G +Y + P+ + N ++ K+ LLS A +
Sbjct: 358 ISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAM 417
Query: 1219 ASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGT 1278
+Q I ++E +G+G+QW ++ + DD FG + ++L DS +Y L+ WY+ VFPG
Sbjct: 418 GAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQ 477
Query: 1279 YGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPE 1338
+G+ PWYF I+PSYW C KP G + S + + + E E
Sbjct: 478 FGVPQPWYFFIMPSYW-----CG--KPRAVAG--------KEEEDSDPEKALRNEYFEAE 522
Query: 1339 PKDLTVGVALHGVTKIY--GSK--VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGL 1394
P+DL G+ + ++K++ G+K AV +LNLN YEG IT LLG NGAGKTTT+SMLTGL
Sbjct: 523 PEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGL 582
Query: 1395 FGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQ 1454
F ++G ++ G +I D+ +RK++G+C QHD+LF LT EHL Y +K ++++
Sbjct: 583 FPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLK--GLSRQK 640
Query: 1455 LHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSR 1514
EEVK+ L GL + R LSGGM+RKLSI IALI GS+V+ILDEP++G+D SR
Sbjct: 641 CPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISR 700
Query: 1515 RSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHL 1574
R+IWD++ + K+ RTI+L+TH +DEA++L DRIA + +G L+CCGS +LK+ +G GYH+
Sbjct: 701 RAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHM 760
Query: 1575 TLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSL 1634
TL K+ C+ ++ ++ H+P A L+ G EL ++LP ST + L
Sbjct: 761 TLVKEPH--------CNPEDISQLVHHHVPNATLESSAGAELSFILPRESTH---RFEGL 809
Query: 1635 LRALDNGMGDLNIGCYGISDTTVEEVFLNLTK------ESQKNSAMSLEHLTQKKIG--- 1685
L+ +L I +G S TT+EEVFL + K + Q +L++ +++
Sbjct: 810 FAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWA 869
Query: 1686 -NSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNW 1744
+SN G P D + + +R T + G L ++ A+ +K+ ++ R W
Sbjct: 870 VDSNLCGAMDPSD-GIGALIEEER-----TAVKLNTGLALHCQQFWAMFLKKAAYSWREW 923
Query: 1745 KGLIAQVILPIVFVTTAM 1762
K + AQV++P+ VT A+
Sbjct: 924 KMVAAQVLVPLTCVTLAL 941
Score = 363 bits (933), Expect = e-100
Identities = 217/671 (32%), Positives = 361/671 (53%), Gaps = 38/671 (5%)
Query: 1922 RTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYP--GVQDQEQA 1979
RT+ ++ + YHS L ++N L ++ + + I++ + P P +Q +
Sbjct: 1035 RTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHAS----IVVSNFPQPRSALQAAKDQ 1090
Query: 1980 TISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDM 2039
+AL++L + ++F V E +AK +Q +SG+ V +W++ ++D+
Sbjct: 1091 FNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDL 1150
Query: 2040 VFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAF 2099
+ +L+P + + F + AF + ++ LLLLL+G+A MYL+ F A+
Sbjct: 1151 ISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAY 1210
Query: 2100 ITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIEL 2159
N+ GI + + ++++ + + LE +S+TL +FL+ P C G +
Sbjct: 1211 TRLTIFNILSGIATFLMVTIMRIPAVK------LEELSKTLDHVFLVLPNHCLGMAVSSF 1264
Query: 2160 ----------SQQQSVLDFLKAYGVEYPNETFEMNK--LGAMFVALVSQGTMFFSLRLLI 2207
+ + + K Y ++Y + + +G ++ + G + L LI
Sbjct: 1265 YENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLI 1324
Query: 2208 NESLIKKLRLFF------RKFNSSHVR-ETIDEDEDVRAERLRVESGAAEFDLVQLYCLT 2260
+L+++LR R + R + ED+DV ER R+ + + + L+ +
Sbjct: 1325 ETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPD-SLLHTPLII 1383
Query: 2261 KTYQLIHKK---IIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR 2317
K ++++ ++AV+ +S+ + GECFGLLG NGAGKTT FKMLTG+ +SG+ +
Sbjct: 1384 KELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVG 1443
Query: 2318 NKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRL 2377
S V +GYCPQ DAL D +T E L YAR+ GIPE+ I V LR L
Sbjct: 1444 GHRIS-SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
Query: 2378 HLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQ 2437
L P ++ S G KRKLST +ALIG+P+++ LDEPS+GMDP ++R LW ++ +
Sbjct: 1503 LLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562
Query: 2438 NKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTV--KVHLKNNKV 2495
+ ++I+TSHSMEECEALCTRLAIMV G+F+C+GS QH+KS+FG G+++ KV + +
Sbjct: 1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQE 1622
Query: 2496 TMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQ 2555
+E F+ L FP + L+D+H M+ YH+P A +F +LE K + ++ VSQ
Sbjct: 1623 ALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQ 1682
Query: 2556 TTLEEVFINFA 2566
+LE+VF++FA
Sbjct: 1683 ISLEQVFLSFA 1693
Score = 196 bits (499), Expect = 2e-49
Identities = 170/600 (28%), Positives = 282/600 (47%), Gaps = 34/600 (5%)
Query: 1985 IDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLV 2044
I + L +L+ ++ T + VV+E + + K+ + G+ +W F+ +F L+
Sbjct: 259 IQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLI 318
Query: 2045 PVAFSIGIIAIFKLP--AFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITY 2102
+F + + P A S ++ V LL F +T S+ ++++ F + MA
Sbjct: 319 AASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAA-- 376
Query: 2103 VCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQ 2162
FG + YF + N TL S+ L L G LI +
Sbjct: 377 ------FGGFLYFFTYIPYFFVAPRYNWMTL---SQKLCSCLLSNVAMAMGAQLIGKFEA 427
Query: 2163 QSV----LDFLKAYGVEYPNETFEMNK-LGAMFVALVSQGTMFFSLRLLINESLIKKLRL 2217
+ + D L V+ + F + LG + + V G + + + +
Sbjct: 428 KGMGIQWRDLLSPVNVD---DDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPW 484
Query: 2218 FFRKFNSSHVRETI----DEDEDVRAER-LRVESGAAE-FDLV---QLYCLTKTYQLIHK 2268
+F S + E+ED E+ LR E AE DLV ++ L+K +++ +K
Sbjct: 485 YFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK 544
Query: 2269 KIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDS 2328
AV ++++ + G+ LLG NGAGKTT MLTG P+SG I S V
Sbjct: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQI 604
Query: 2329 HSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATS 2388
SL G CPQ D L D +TV EHLYFYA++ G+ + E V ++L + L + +
Sbjct: 605 RKSL-GLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSR 663
Query: 2389 MCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHS 2448
S G +RKLS +ALI +L+LDEP+SGMD S+R +W ++ + ++ +++LT+H
Sbjct: 664 FLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDR-TIVLTTHF 722
Query: 2449 MEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHF 2508
M+E + L R+AIM G+ QC GS +K ++G G+ + + +K E +++ + H
Sbjct: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTL-VKEPHCNPEDISQLVHHHV 781
Query: 2509 PKTYLKDQHLSMLEYHVP-VTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAK 2567
P L+ + L + +P + +F LE + L I +F S TT+EEVF+ K
Sbjct: 782 PNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
Score = 191 bits (484), Expect = 1e-47
Identities = 162/626 (25%), Positives = 292/626 (46%), Gaps = 61/626 (9%)
Query: 1067 YSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLI-ESVGFLLVT 1125
+ + + L+ A + F V E+ ++ + GV+ S + + L+ + + FL+ +
Sbjct: 1098 FDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPS 1157
Query: 1126 IVILIIILKFGNILPKTNGFIL--FLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIY 1183
+++L++ F +G + L Y +++I + YL++ FF A ++
Sbjct: 1158 LLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFN 1217
Query: 1184 IIAFFPFIVLVTVEN-------ELSYVLK-VFMSLLSPTAFSYASQYIARYEEQG----- 1230
I++ ++VT+ ELS L VF+ L + S + YE +
Sbjct: 1218 ILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSS 1277
Query: 1231 -IGLQWENMYTSPVQDDTTSF-----GWLCCLILADSFIYFLIAWYVR-NVFPGTYGMAA 1283
+ + Y Q++ ++ G + A Y ++ + + N+ G+
Sbjct: 1278 EVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGIL- 1336
Query: 1284 PWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLT 1343
CA ++ ++ ++T + + + + E + + P P L
Sbjct: 1337 ----------------CA-LRRRRTLTELYTRMPVLPEDQDVADER--TRILAPSPDSLL 1377
Query: 1344 -VGVALHGVTKIYGSKV---AVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA 1399
+ + ++K+Y +V AVD L+L +G LLG NGAGKTTT MLTG ++
Sbjct: 1378 HTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTS 1437
Query: 1400 GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIK-VPHWTKKQLHEE 1458
G FV G I +D+ VR+ +G C Q D L ++T +E L++Y ++ +P ++ +
Sbjct: 1438 GDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIP---ERHIGAC 1494
Query: 1459 VKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIW 1518
V+ TL+ L H +K V T SGG KRKLS IALIG V+ LDEPSTG+DP +RR +W
Sbjct: 1495 VENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 1519 DVISK-NKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLT 1577
D +++ ++ + II+++H ++E E L R+A + QG +C GSP +LK FG GY L
Sbjct: 1555 DTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAK 1614
Query: 1578 KKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRA 1637
+ A A + P + L+++ G + Y LP ++ +
Sbjct: 1615 VQSEGQQEA-----LEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDL----SWAKVFGI 1665
Query: 1638 LDNGMGDLNIGCYGISDTTVEEVFLN 1663
L+ + Y +S ++E+VFL+
Sbjct: 1666 LEKAKEKYGVDDYSVSQISLEQVFLS 1691
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 290 bits (743), Expect = 1e-77
Identities = 209/784 (26%), Positives = 385/784 (49%), Gaps = 64/784 (8%)
Query: 1015 QIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLM 1074
Q + F LQ SI+ AII+L+T + + +A+ T + I L+
Sbjct: 167 QYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLV 226
Query: 1075 VAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILK 1134
+A+ F +V EK+ ++ E++K+MG++ + + +W++ + + +++ +I
Sbjct: 227 IAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIAT 286
Query: 1135 FGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194
+ P+++ ++FL F Y S + + +++ F + ++ + + F ++++
Sbjct: 287 ASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMII 346
Query: 1195 TVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLC 1254
+E+ ++ +F T F + E+ G + N+ P T
Sbjct: 347 LIESFPKSLVWLFSPFCHCT-FVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITII---- 401
Query: 1255 CLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFT 1314
++ +S Y L+A Y+ V PG +G+ + + PSYW + K N +
Sbjct: 402 -MLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSK---------SKRN---YE 448
Query: 1315 NIMMQNTNPSASPEYMFSSNIEPEPKDLT--VGVALHGVTKIYGSK----VAVDNLNLNF 1368
+ N N + S FS IEP + + + G+ K Y K A+ NL+ +
Sbjct: 449 ELSEGNVNGNIS----FSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDI 504
Query: 1369 YEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT--DLHTVRKNMGVCMQH 1426
YEG IT+LLG +G GK+T +++L GL S G +YG + ++ RK +G+C Q
Sbjct: 505 YEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQL 564
Query: 1427 DVLFSYLTTKEHLLLYGSIK-VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKR 1485
D+ F LT +E+L + SIK +P + +EV++ L D + + + + LSGG KR
Sbjct: 565 DIHFDVLTVEENLSILASIKGIP---ANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKR 621
Query: 1486 KLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSD 1545
KLS+ IA++G ++++LDEP+ G+DPCSR +W+++ K R + STH +DEA++L+D
Sbjct: 622 KLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILAD 681
Query: 1546 RIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPE 1605
R A + QG L+C GS +LK +G GY L++ K C T +++++++ H+P
Sbjct: 682 RKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDK--------YCATESLSSLVKQHIPG 733
Query: 1606 AYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLT 1665
A L + +LVY LP K + L ALD+ +L + YG+S TT+E+VFL L
Sbjct: 734 ATLLQQNDQQLVYSLP---FKDMDKFSGLFSALDS-HSNLGVISYGVSMTTLEDVFLKLE 789
Query: 1666 KESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKIL----TRGERLDG 1721
E++ + A TQ+ P + + S +F + + +L T+ +
Sbjct: 790 VEAEIDQA-DYSVFTQQ------------PLEEEMDSKSFDEMEQSLLILSETKAALVST 836
Query: 1722 FGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNS-SNSYPEIQIS 1780
L +++ I F +R K + + ++L ++F T + + + +S N+ I++
Sbjct: 837 MSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLV 896
Query: 1781 PSLY 1784
P LY
Sbjct: 897 PDLY 900
Score = 246 bits (627), Expect = 3e-64
Identities = 196/687 (28%), Positives = 323/687 (47%), Gaps = 88/687 (12%)
Query: 1935 HSLPAYLNSLNNFLL-RVNMSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSI 1993
+SLP +N ++N+ L +N+++ I ++S P+ QE I I++ ++
Sbjct: 978 YSLPILVNIISNYYLYHLNVTET------IQIWSTPF----FQEITDIVFKIELYFQAAL 1027
Query: 1994 LMGYSVTTAS--FVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIG 2051
L G VT F H+ KA +SG+ + YW+ + D+ + + + +G
Sbjct: 1028 L-GIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLG 1086
Query: 2052 IIAIFKLPA-FYSENNLGAVSLLL------LLFGY-ATFSWMYLL------AGLFHETGM 2097
+ F FY+ L V L+ +LF Y A+F++ +L + ++ +
Sbjct: 1087 SLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAAL 1146
Query: 2098 AFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLI 2157
A I + F G L + + I I+P
Sbjct: 1147 ACIAITEITFFMGYTIATILHYAFCI-------------------IIPIYPLL------- 1180
Query: 2158 ELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTM----FFSLRLLINESLIK 2213
++ F+K N + VA++S F L+ + +
Sbjct: 1181 -----GCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGR 1235
Query: 2214 KLRL--FFRKFNSSHVRETI-------DEDEDVRAERLRVES-----GAAEFDLVQLYCL 2259
+R FFR ++ + DEDEDV+AERL+V+ E + + L
Sbjct: 1236 SIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNL 1295
Query: 2260 TKTYQ-----LIHKKI--IAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSG 2312
K Y L+ +K+ +A IS + GE GLLG NGAGK+TI +L GDI P+SG
Sbjct: 1296 HKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSG 1355
Query: 2313 NILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHK 2372
+ + + + D +GYCPQ + L T++EH Y V G+ D+KE + +
Sbjct: 1356 QVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISR 1415
Query: 2373 LLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKII 2432
+ L L + G KRKL AL+++G P I LLDEPS+GMDPK+K+H+W+ I
Sbjct: 1416 ITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAI 1475
Query: 2433 SEEVQN-KCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLK 2491
+N K + ILT+H MEE EA+C R+AIMV+G+ +CIG++QH+KS+FG+G+ +++ LK
Sbjct: 1476 RTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK 1535
Query: 2492 N--NKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVP-VTAGGVANIFDLLETNKTALNI 2548
+ + ++ L + +Q FP ++ S+L Y +P ++ F LE K A I
Sbjct: 1536 DWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAI 1595
Query: 2549 TNFLVSQTTLEEVFINFAKDQKSYETA 2575
+ SQ TLE+VF+ K+Q+ + +
Sbjct: 1596 EEYSFSQATLEQVFVELTKEQEEEDNS 1622
Score = 202 bits (514), Expect = 3e-51
Identities = 154/594 (25%), Positives = 287/594 (48%), Gaps = 45/594 (7%)
Query: 1988 LVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVT-NFIYDMVFYLVPV 2046
++ + +++ +S ++V E + K K+ I G+ T +W++ +Y + +L+ +
Sbjct: 220 VILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSL 279
Query: 2047 AFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVN 2106
++ A P +++ + LL L+G ++ + +L LF ++ I V
Sbjct: 280 LMAVIATASLLFP----QSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVT 335
Query: 2107 LFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVL 2166
+ FG + L ++ LI K + +F FC +I ++Q +
Sbjct: 336 VAFGF---IGLMII--------------LIESFPKSLVWLFSPFCHCTFVIGIAQVMHLE 378
Query: 2167 DFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESL-----IKKLRLFFRK 2221
DF + G + N T L + L + L + +++ + +++ L+F K
Sbjct: 379 DFNE--GASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLK 436
Query: 2222 ----FNSSHVRETIDEDE---DVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHKKII 2271
S E + E ++ + +E ++EF + +++ + KTY+ + +
Sbjct: 437 PSYWSKSKRNYEELSEGNVNGNISFSEI-IEPVSSEFVGKEAIRISGIQKTYRKKGENVE 495
Query: 2272 AVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR-NKTGSLGHVDSHS 2330
A+ N+S I G+ LLG +G GK+T+ +L G PS G I ++ + +
Sbjct: 496 ALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEAR 555
Query: 2331 SLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMC 2390
++G CPQ D D++TVEE+L A + GIP +I + V K+L L + KD
Sbjct: 556 KMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKL 615
Query: 2391 SYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSME 2450
S G KRKLS +A++G P ILLLDEP++GMDP S+ +W ++ N+ +V T H M+
Sbjct: 616 SGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFST-HFMD 674
Query: 2451 ECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPK 2510
E + L R A++ G +C+GS +KS++G G+ + +++ T E+L+ ++ H P
Sbjct: 675 EADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT-ESLSSLVKQHIPG 733
Query: 2511 TYLKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFI 2563
L Q+ L Y +P + +F L+++ L + ++ VS TTLE+VF+
Sbjct: 734 ATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFL 786
Score = 160 bits (404), Expect = 2e-38
Identities = 108/319 (33%), Positives = 166/319 (52%), Gaps = 19/319 (5%)
Query: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFV--YGKDIKTDLHT 1415
KVA ++ +G I LLGPNGAGK+T I++L G ++G +F+ Y + D +
Sbjct: 1313 KVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDS 1372
Query: 1416 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR 1475
+ K MG C Q + L+ T +EH +YG++K + + E + R L H K
Sbjct: 1373 L-KCMGYCPQINPLWPDTTLQEHFEIYGAVK--GMSASDMKEVISRITHALDLKEHLQKT 1429
Query: 1476 VGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVIS---KNKTARTIIL 1532
V L G+KRKL +++++G ++ +LDEPSTG+DP +++ +W I KN+ R IL
Sbjct: 1430 VKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNR-KRAAIL 1488
Query: 1533 STHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKK-SPNLNANAVCD 1591
+TH+++EAE + DR+A + G LRC G+ +LK FG GY L + K NL +
Sbjct: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVD---- 1544
Query: 1592 TMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYG 1651
+ IQ P A +E L Y +P V S + L+ I Y
Sbjct: 1545 --RLQREIQYIFPNASRQESFSSILAYKIP--KEDVQSLSQSFFK-LEEAKHAFAIEEYS 1599
Query: 1652 ISDTTVEEVFLNLTKESQK 1670
S T+E+VF+ LTKE ++
Sbjct: 1600 FSQATLEQVFVELTKEQEE 1618
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 290 bits (743), Expect = 1e-77
Identities = 209/784 (26%), Positives = 385/784 (49%), Gaps = 64/784 (8%)
Query: 1015 QIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLM 1074
Q + F LQ SI+ AII+L+T + + +A+ T + I L+
Sbjct: 167 QYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLV 226
Query: 1075 VAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILK 1134
+A+ F +V EK+ ++ E++K+MG++ + + +W++ + + +++ +I
Sbjct: 227 IAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIAT 286
Query: 1135 FGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194
+ P+++ ++FL F Y S + + +++ F + ++ + + F ++++
Sbjct: 287 ASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMII 346
Query: 1195 TVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLC 1254
+E+ ++ +F T F + E+ G + N+ P T
Sbjct: 347 LIESFPKSLVWLFSPFCHCT-FVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITII---- 401
Query: 1255 CLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFT 1314
++ +S Y L+A Y+ V PG +G+ + + PSYW + K N +
Sbjct: 402 -MLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSK---------SKRN---YE 448
Query: 1315 NIMMQNTNPSASPEYMFSSNIEPEPKDLT--VGVALHGVTKIYGSK----VAVDNLNLNF 1368
+ N N + S FS IEP + + + G+ K Y K A+ NL+ +
Sbjct: 449 ELSEGNVNGNIS----FSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDI 504
Query: 1369 YEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT--DLHTVRKNMGVCMQH 1426
YEG IT+LLG +G GK+T +++L GL S G +YG + ++ RK +G+C Q
Sbjct: 505 YEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQL 564
Query: 1427 DVLFSYLTTKEHLLLYGSIK-VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKR 1485
D+ F LT +E+L + SIK +P + +EV++ L D + + + + LSGG KR
Sbjct: 565 DIHFDVLTVEENLSILASIKGIP---ANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKR 621
Query: 1486 KLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSD 1545
KLS+ IA++G ++++LDEP+ G+DPCSR +W+++ K R + STH +DEA++L+D
Sbjct: 622 KLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILAD 681
Query: 1546 RIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPE 1605
R A + QG L+C GS +LK +G GY L++ K C T +++++++ H+P
Sbjct: 682 RKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDK--------YCATESLSSLVKQHIPG 733
Query: 1606 AYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLT 1665
A L + +LVY LP K + L ALD+ +L + YG+S TT+E+VFL L
Sbjct: 734 ATLLQQNDQQLVYSLP---FKDMDKFSGLFSALDS-HSNLGVISYGVSMTTLEDVFLKLE 789
Query: 1666 KESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKIL----TRGERLDG 1721
E++ + A TQ+ P + + S +F + + +L T+ +
Sbjct: 790 VEAEIDQA-DYSVFTQQ------------PLEEEMDSKSFDEMEQSLLILSETKAALVST 836
Query: 1722 FGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNS-SNSYPEIQIS 1780
L +++ I F +R K + + ++L ++F T + + + +S N+ I++
Sbjct: 837 MSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLV 896
Query: 1781 PSLY 1784
P LY
Sbjct: 897 PDLY 900
Score = 246 bits (627), Expect = 3e-64
Identities = 196/687 (28%), Positives = 323/687 (47%), Gaps = 88/687 (12%)
Query: 1935 HSLPAYLNSLNNFLL-RVNMSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSI 1993
+SLP +N ++N+ L +N+++ I ++S P+ QE I I++ ++
Sbjct: 978 YSLPILVNIISNYYLYHLNVTET------IQIWSTPF----FQEITDIVFKIELYFQAAL 1027
Query: 1994 LMGYSVTTAS--FVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIG 2051
L G VT F H+ KA +SG+ + YW+ + D+ + + + +G
Sbjct: 1028 L-GIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLG 1086
Query: 2052 IIAIFKLPA-FYSENNLGAVSLLL------LLFGY-ATFSWMYLL------AGLFHETGM 2097
+ F FY+ L V L+ +LF Y A+F++ +L + ++ +
Sbjct: 1087 SLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAAL 1146
Query: 2098 AFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLI 2157
A I + F G L + + I I+P
Sbjct: 1147 ACIAITEITFFMGYTIATILHYAFCI-------------------IIPIYPLL------- 1180
Query: 2158 ELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTM----FFSLRLLINESLIK 2213
++ F+K N + VA++S F L+ + +
Sbjct: 1181 -----GCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGR 1235
Query: 2214 KLRL--FFRKFNSSHVRETI-------DEDEDVRAERLRVES-----GAAEFDLVQLYCL 2259
+R FFR ++ + DEDEDV+AERL+V+ E + + L
Sbjct: 1236 SIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNL 1295
Query: 2260 TKTYQ-----LIHKKI--IAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSG 2312
K Y L+ +K+ +A IS + GE GLLG NGAGK+TI +L GDI P+SG
Sbjct: 1296 HKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSG 1355
Query: 2313 NILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHK 2372
+ + + + D +GYCPQ + L T++EH Y V G+ D+KE + +
Sbjct: 1356 QVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISR 1415
Query: 2373 LLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKII 2432
+ L L + G KRKL AL+++G P I LLDEPS+GMDPK+K+H+W+ I
Sbjct: 1416 ITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAI 1475
Query: 2433 SEEVQN-KCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLK 2491
+N K + ILT+H MEE EA+C R+AIMV+G+ +CIG++QH+KS+FG+G+ +++ LK
Sbjct: 1476 RTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK 1535
Query: 2492 N--NKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVP-VTAGGVANIFDLLETNKTALNI 2548
+ + ++ L + +Q FP ++ S+L Y +P ++ F LE K A I
Sbjct: 1536 DWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAI 1595
Query: 2549 TNFLVSQTTLEEVFINFAKDQKSYETA 2575
+ SQ TLE+VF+ K+Q+ + +
Sbjct: 1596 EEYSFSQATLEQVFVELTKEQEEEDNS 1622
Score = 202 bits (514), Expect = 3e-51
Identities = 154/594 (25%), Positives = 287/594 (48%), Gaps = 45/594 (7%)
Query: 1988 LVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVT-NFIYDMVFYLVPV 2046
++ + +++ +S ++V E + K K+ I G+ T +W++ +Y + +L+ +
Sbjct: 220 VILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSL 279
Query: 2047 AFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVN 2106
++ A P +++ + LL L+G ++ + +L LF ++ I V
Sbjct: 280 LMAVIATASLLFP----QSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVT 335
Query: 2107 LFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVL 2166
+ FG + L ++ LI K + +F FC +I ++Q +
Sbjct: 336 VAFGF---IGLMII--------------LIESFPKSLVWLFSPFCHCTFVIGIAQVMHLE 378
Query: 2167 DFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESL-----IKKLRLFFRK 2221
DF + G + N T L + L + L + +++ + +++ L+F K
Sbjct: 379 DFNE--GASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLK 436
Query: 2222 ----FNSSHVRETIDEDE---DVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHKKII 2271
S E + E ++ + +E ++EF + +++ + KTY+ + +
Sbjct: 437 PSYWSKSKRNYEELSEGNVNGNISFSEI-IEPVSSEFVGKEAIRISGIQKTYRKKGENVE 495
Query: 2272 AVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR-NKTGSLGHVDSHS 2330
A+ N+S I G+ LLG +G GK+T+ +L G PS G I ++ + +
Sbjct: 496 ALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEAR 555
Query: 2331 SLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMC 2390
++G CPQ D D++TVEE+L A + GIP +I + V K+L L + KD
Sbjct: 556 KMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKL 615
Query: 2391 SYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSME 2450
S G KRKLS +A++G P ILLLDEP++GMDP S+ +W ++ N+ +V T H M+
Sbjct: 616 SGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFST-HFMD 674
Query: 2451 ECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPK 2510
E + L R A++ G +C+GS +KS++G G+ + +++ T E+L+ ++ H P
Sbjct: 675 EADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT-ESLSSLVKQHIPG 733
Query: 2511 TYLKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFI 2563
L Q+ L Y +P + +F L+++ L + ++ VS TTLE+VF+
Sbjct: 734 ATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFL 786
Score = 160 bits (404), Expect = 2e-38
Identities = 108/319 (33%), Positives = 166/319 (52%), Gaps = 19/319 (5%)
Query: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFV--YGKDIKTDLHT 1415
KVA ++ +G I LLGPNGAGK+T I++L G ++G +F+ Y + D +
Sbjct: 1313 KVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDS 1372
Query: 1416 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR 1475
+ K MG C Q + L+ T +EH +YG++K + + E + R L H K
Sbjct: 1373 L-KCMGYCPQINPLWPDTTLQEHFEIYGAVK--GMSASDMKEVISRITHALDLKEHLQKT 1429
Query: 1476 VGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVIS---KNKTARTIIL 1532
V L G+KRKL +++++G ++ +LDEPSTG+DP +++ +W I KN+ R IL
Sbjct: 1430 VKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNR-KRAAIL 1488
Query: 1533 STHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKK-SPNLNANAVCD 1591
+TH+++EAE + DR+A + G LRC G+ +LK FG GY L + K NL +
Sbjct: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVD---- 1544
Query: 1592 TMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYG 1651
+ IQ P A +E L Y +P V S + L+ I Y
Sbjct: 1545 --RLQREIQYIFPNASRQESFSSILAYKIP--KEDVQSLSQSFFK-LEEAKHAFAIEEYS 1599
Query: 1652 ISDTTVEEVFLNLTKESQK 1670
S T+E+VF+ LTKE ++
Sbjct: 1600 FSQATLEQVFVELTKEQEE 1618
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 277 bits (709), Expect = 9e-74
Identities = 189/662 (28%), Positives = 328/662 (49%), Gaps = 54/662 (8%)
Query: 1019 RAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPY---PCFMKDNFLTSVSYSLPIVLMV 1075
+ F+ Q +I AIIE+ T + E V I P K + + +V
Sbjct: 86 KGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSFS 145
Query: 1076 AWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKF 1135
+++ F + V + + + + M +MG+ + + +W + + F+ + + + +++
Sbjct: 146 SFIYFASLNVAR----ERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITS 201
Query: 1136 GNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVT 1195
I+ T ++F +S Y S+IA+++L+SV +A L G L + F+ +
Sbjct: 202 IPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTV--FWGCLGFTV 259
Query: 1196 VENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCC 1255
+ +L L +SLLSP AF+ I + G+ + + + T F
Sbjct: 260 LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFF----- 314
Query: 1256 LILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTN 1315
++ D+ Y + Y V P G F + S+W K + ++ +F N
Sbjct: 315 ILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWS--------KHQNTHHEIFEN 366
Query: 1316 IMMQNTNPSASPEYMFSSNIEPEPKDL--TVGVALHGVTKIYGSKV----AVDNLNLNFY 1369
+PE+ + EP + + + V K Y K A+ + + Y
Sbjct: 367 --------EINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIY 418
Query: 1370 EGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGVCMQHD 1427
EG IT++LG NGAGK+T +++L+GL ++ G+ +Y + TD+ +RKN+G C Q +
Sbjct: 419 EGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFN 478
Query: 1428 VLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKL 1487
F +LT +E+L ++ IK K++ +EVKR + + + S + LSGG KRKL
Sbjct: 479 FQFDFLTVRENLRVFAKIKGIQ--PKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKL 536
Query: 1488 SISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRI 1547
++ IA++G +V++LDEP+ G+DP SR +W ++ ++K R I+ ST +DEA++L+DR
Sbjct: 537 TLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRK 596
Query: 1548 AFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAY 1607
FL G L+C GS +LK +G GYHL +L+ N +CDT +T++I+ H+P+A
Sbjct: 597 VFLSNGKLKCAGSSLFLKRKWGIGYHL--------SLHRNEMCDTEKITSLIKQHIPDAK 648
Query: 1608 LKEDIGGELVYVLPPFST-KVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTK 1666
L + +LVY LP T K Y L + D G+ + Y +S T++ EVFLNL
Sbjct: 649 LTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQGIRN-----YAVSVTSLNEVFLNLEG 703
Query: 1667 ES 1668
+S
Sbjct: 704 KS 705
Score = 237 bits (604), Expect = 1e-61
Identities = 178/598 (29%), Positives = 302/598 (50%), Gaps = 67/598 (11%)
Query: 2009 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLG 2068
+ +++ + ISG+ + YW + D+ Y + + FSI +I F F L
Sbjct: 955 ISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFL-ILFSIHLIYYFIFLGFQLSWELM 1013
Query: 2069 AVSLLLLLFGYAT--FSWMYLLAGLFHE--------TGMAFITYVCVNLFFGINSIVSLS 2118
V L++ + G A Y+L+ +F + + FI +CV S + +S
Sbjct: 1014 FV-LVVCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICV-------STIMVS 1065
Query: 2119 VVYFLSKEKPNDPTLELISETLKRIFLIFPQF-CFGYGLIELSQQQSVLDFLKAYGVEYP 2177
Y E ++ L IF+ P F GY ++ + LDF++
Sbjct: 1066 TQY------------EKLNLILCMIFI--PSFTLLGYVMLLIQ-----LDFMRNLD-SLD 1105
Query: 2178 NETFEMNK--LGAMFVALVSQGTMFFSLRLL--------INESLIKKLRLFFRKFNSSHV 2227
N E+NK L + + F +R L +N+ + ++ R+ +
Sbjct: 1106 NRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDPVFRISPRSRE-THPNP 1164
Query: 2228 RETIDEDEDVRAERLRVESGAA-----EFDLVQLYCLTKTYQ-------LIHKKIIAVNN 2275
E +EDEDV+AER++ + E ++ CL K Y KK IA+ N
Sbjct: 1165 EEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIRN 1224
Query: 2276 ISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHV-DSHSSLVG 2334
+S + GE GLLG NGAGK+T KM+TG P++G ++++ S+ D+ +G
Sbjct: 1225 VSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLG 1284
Query: 2335 YCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGT 2394
YCPQE++L +T++EHL YA V G+ ++D ++ +L+ L L S G
Sbjct: 1285 YCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGI 1344
Query: 2395 KRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNK-CSVILTSHSMEECE 2453
KRKL L+++G PS++LLDEP +GMDP+ ++ +W+I+ V+NK +LT+H M E E
Sbjct: 1345 KRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAE 1404
Query: 2454 ALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYL 2513
A+C R+A+MV+G +CIGS+QH+K++FGR + +++ +K T+ ++L FP+
Sbjct: 1405 AVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKL-FPQAAW 1463
Query: 2514 KDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQK 2570
++++ S++ Y +PV ++ F LE K N+ + +SQ TLE+VF+ K+Q+
Sbjct: 1464 QERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKEQE 1521
Score = 181 bits (458), Expect = 1e-44
Identities = 156/601 (25%), Positives = 283/601 (47%), Gaps = 77/601 (12%)
Query: 1999 VTTASFVTYV---VREHQTKAKQLQHISGIGVTCYWVT------NFIYDMVFYL------ 2043
V+ +SF+ + V + K K+L + G+ + +W++ FI+ M ++
Sbjct: 142 VSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITS 201
Query: 2044 VPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYV 2103
+P+ F G + IF L + Y +SL+ L F + +LAGL G F +
Sbjct: 202 IPIVFHTGFMVIFTLYSLYG------LSLIALAFLMSVLIRKPMLAGL---AGFLFTVFW 252
Query: 2104 CVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQ 2163
F + + LS+ + LS P F F G+ +++
Sbjct: 253 GCLGFTVLYRQLPLSLGWVLSLLSP---------------------FAFTAGMAQITHLD 291
Query: 2164 SVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLR------L 2217
+ L GV +P+ + + K+ A F L T+F+ + L E ++ L
Sbjct: 292 NYLS-----GVIFPDPSGDSYKMIATFFILAFD-TLFYLIFTLYFERVLPDKDGHGDSPL 345
Query: 2218 FFRK--FNSSHVRETIDE--DEDVRAERLRVESG---AAEF---DLVQLYCLTKTYQLIH 2267
FF K F S H + T E + ++ E +S + EF + +++ + K Y
Sbjct: 346 FFLKSSFWSKH-QNTHHEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKT 404
Query: 2268 KKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN-KTGSLGHV 2326
K+ A+ I I G+ +LG NGAGK+T+ +L+G + + G+ I N + + +
Sbjct: 405 GKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDM 464
Query: 2327 DSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRA 2386
+ +G+CPQ + D +TV E+L +A++ GI K++++ V +++ L + +D
Sbjct: 465 EEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDII 524
Query: 2387 TSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTS 2446
S G KRKL+ +A++G P +LLLDEP++G+DP S+ +W ++ E ++ ++ ++
Sbjct: 525 AKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRL-ILFST 583
Query: 2447 HSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQL 2506
M+E + L R + NGK +C GS +K ++G G+ + +H +N E +T ++
Sbjct: 584 QFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLH-RNEMCDTEKITSLIKQ 642
Query: 2507 HFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALN---ITNFLVSQTTLEEVFI 2563
H P L + L Y +P+ N F L ++ + I N+ VS T+L EVF+
Sbjct: 643 HIPDAKLTTESEEKLVYSLPLEK---TNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFL 699
Query: 2564 N 2564
N
Sbjct: 700 N 700
Score = 158 bits (399), Expect = 8e-38
Identities = 107/317 (33%), Positives = 161/317 (50%), Gaps = 19/317 (5%)
Query: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGK--DIKTDLHT 1415
K+A+ N++ +G + LLG NGAGK+T+I M+TG +AG + + G ++
Sbjct: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDN 1278
Query: 1416 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR 1475
K +G C Q + L+ LT KEHL LY ++K K+ + R ++ L
Sbjct: 1279 SLKFLGYCPQENSLWPKLTMKEHLELYAAVK--GLGKEDAALSISRLVEALKLQEQLKAP 1336
Query: 1476 VGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVIS---KNKTARTIIL 1532
V TLS G+KRKL ++++G VV+LDEP TG+DP ++ +W ++ KNK R +L
Sbjct: 1337 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNK-ERGTLL 1395
Query: 1533 STHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDT 1592
+TH++ EAE + DR+A + G LRC GS +LK FG Y L + K K P
Sbjct: 1396 TTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI-KMKEPT-------QV 1447
Query: 1593 MAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGI 1652
A+ I P+A +E + Y LP L A+ N+ Y +
Sbjct: 1448 EALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQ---TFNLEEYSL 1504
Query: 1653 SDTTVEEVFLNLTKESQ 1669
S T+E+VFL L KE +
Sbjct: 1505 SQATLEQVFLELCKEQE 1521
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 270 bits (690), Expect = 1e-71
Identities = 204/746 (27%), Positives = 360/746 (48%), Gaps = 64/746 (8%)
Query: 1017 YGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPC--FMKDNFLTSVSYSLPIVLM 1074
+ R F+ LQ +I AIIE+ T E + V AI F+ N L + + L +L
Sbjct: 171 WNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLH 230
Query: 1075 VAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILK 1134
+ +V+ F+ V ++ + MKMMG+ + + +W + GF+ + + + II+
Sbjct: 231 FSPLVY---FISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIIT 287
Query: 1135 FGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194
F I+ T ++F+ F Y S++A+ +L+SV + L+ L+ + F+ +
Sbjct: 288 FTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTL--FWGCLGFT 345
Query: 1195 TVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLC 1254
+L L+ +++ SP AF+ I + + G+ ++ P D T
Sbjct: 346 VFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGV----IFPDPSGDSYTMIATFS 401
Query: 1255 CLILADSFIYFLIAWYVRNVFP-GTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMF 1313
L+L D IY L+A Y + P G +P +F S ++ + A+V
Sbjct: 402 MLLL-DGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKV---------- 450
Query: 1314 TNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIY----GSKVAVDNLNLNFY 1369
++ + P + + PE + + + V K Y G A+ L + Y
Sbjct: 451 ----IEKEIDAEHPSDDYFEPVAPEFQGKEA-IRIRNVKKEYKGKSGKVEALKGLLFDIY 505
Query: 1370 EGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT--DLHTVRKNMGVCMQHD 1427
EG IT++LG +GAGK++ +++L GL + G++ +Y K++ DL +RK GVC Q +
Sbjct: 506 EGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFN 565
Query: 1428 VLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKL 1487
V F LT KE+L L+ IK H K++ +EV+R L + + + + LS G KRKL
Sbjct: 566 VQFDILTVKENLSLFAKIKGIHL--KEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKL 623
Query: 1488 SISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRI 1547
+ I ++G ++++LDEP+TG+DP SR +W ++ + + I+ ST +DEA++L+DR
Sbjct: 624 TFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRK 683
Query: 1548 AFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAY 1607
+ G L+C GS +LK +G GYHL +L+ N +C+ +T+ I H+P+A
Sbjct: 684 VIMSNGRLKCAGSSMFLKRRWGLGYHL--------SLHRNEICNPEQITSFITHHIPDAK 735
Query: 1608 LKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKE 1667
LK + +LVY LP + + + L LD D + Y IS +T+ EVF+ L E
Sbjct: 736 LKTENKEKLVYTLP---LERTNTFPDLFSDLDK-CSDQGVTGYDISMSTLNEVFMKL--E 789
Query: 1668 SQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLK 1727
Q E + + S +++ ++ S+F++ + GL
Sbjct: 790 GQSTIEQDFEQVEMIRDSES-------LNEMELAHSSFSEMQTAV-------SDMGLWRM 835
Query: 1728 KIMAILIKRFHHTRRNWKGLIAQVIL 1753
++ A+ RF +R K L+ +++
Sbjct: 836 QVFAMARLRFLKLKRQTKVLLTLLLV 861
Score = 231 bits (588), Expect = 9e-60
Identities = 189/668 (28%), Positives = 318/668 (47%), Gaps = 77/668 (11%)
Query: 1935 HSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYP--------GVQDQEQATISSLID 1986
H P +N ++N LL++ ++ +H I + S P+P G+ D S
Sbjct: 972 HCFPILMNIISNGLLQM----FNHTQH-IRIESSPFPLSHIGLWTGLPD------GSFFL 1020
Query: 1987 ILVALSILMGYSVTTASFVTY-VVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVP 2045
LV SI + ++T + +++ AK ISG+ + YW + D+ F++
Sbjct: 1021 FLVLCSI--------SPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFI-- 1070
Query: 2046 VAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCV 2105
+I + FY EN LL+ F+ + + G + + F Y+
Sbjct: 1071 ------LILLLMYLIFYIEN-----MQYLLITSQIVFALVIVTPG--YAASLVFFIYMIS 1117
Query: 2106 NLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSV 2165
+F L YF ++ LI+ I + Y L+ V
Sbjct: 1118 FIFRKRRKNSGLWSFYFFFASTIMF-SITLINHFDLSILITTMVLVPSYTLLGFKTFLEV 1176
Query: 2166 LDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL----FFRK 2221
D + + E+P FE++ + + T+ F L E K R+ FR
Sbjct: 1177 RD--QEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRI 1234
Query: 2222 FNSS-----HVRETIDEDEDVRAERLRVESGAA-----EFDLVQLYCLTKTYQ------- 2264
S + E IDEDED++ ER+R + E ++ CL K Y
Sbjct: 1235 SPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCF 1294
Query: 2265 LIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLG 2324
KK IA NIS + GE GLLG NGAGK++ +M++G P++G + ++ + LG
Sbjct: 1295 SKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLG 1354
Query: 2325 HVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKD 2384
H+ GYCPQE+ L ++T+ EHL YA V G+ + D + + +L+ L +
Sbjct: 1355 HL-------GYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLN 1407
Query: 2385 RATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSVI 2443
+ G RKL L+L+G +LLLDEPS+G+DP ++ +W+ I V+N + V+
Sbjct: 1408 VPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL 1467
Query: 2444 LTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKF 2503
LT+H++ E EALC R+AIMV+G+ +CIGS+QH+K++ G+ + +++ +K T+
Sbjct: 1468 LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEI 1527
Query: 2504 MQLHFPKTYLKDQHLSMLEYHVPVT-AGGVANIFDLLETNKTALNITNFLVSQTTLEEVF 2562
++L FP+ ++++ S+L Y +PV ++ F LE K N+ + +SQ TLE+VF
Sbjct: 1528 LKL-FPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVF 1586
Query: 2563 INFAKDQK 2570
+ +K+Q+
Sbjct: 1587 LELSKEQE 1594
Score = 195 bits (495), Expect = 6e-49
Identities = 147/577 (25%), Positives = 284/577 (49%), Gaps = 44/577 (7%)
Query: 2004 FVTYVVREHQTKAKQLQHISGIGVTCYWVT-NFIYDMVFYLVPVAFSIGIIAIFKLPAFY 2062
F++ V + + K+K L + G+ + +W++ IY +++ SI + I
Sbjct: 237 FISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFII----SIFVTIIITFTQII 292
Query: 2063 SENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYF 2122
+ +L L+G + + ++L++ L + + + + LF+G + +V Y
Sbjct: 293 VMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGC---LGFTVFY- 348
Query: 2123 LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFE 2182
E + +L+ I I F F G+I++ + LD+ GV +P+ + +
Sbjct: 349 -----------EQLPSSLEWILNICSPFAFTTGMIQIIK----LDY-NLNGVIFPDPSGD 392
Query: 2183 MNKLGAMFVALVSQGTMFFSLRLLINESLI-----KKLRLFFRKFNSSHVRETIDE---D 2234
+ A F L+ G ++ L L ++ L LFF +S + + +
Sbjct: 393 SYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIE 452
Query: 2235 EDVRAERLR---VESGAAEF---DLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGL 2288
+++ AE E A EF + +++ + K Y+ K+ A+ + I G+ +
Sbjct: 453 KEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAI 512
Query: 2289 LGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGS-LGHVDSHSSLVGYCPQEDALDDLVT 2347
LG +GAGK+++ +L G +P+ G++ I NK S + ++ + G CPQ + D++T
Sbjct: 513 LGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILT 572
Query: 2348 VEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGK 2407
V+E+L +A++ GI K++++ V ++L L + +D S G KRKL+ + ++G
Sbjct: 573 VKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGD 632
Query: 2408 PSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKF 2467
P ILLLDEP++G+DP S+ +W ++ E + ++ ++ SM+E + L R IM NG+
Sbjct: 633 PQILLLDEPTTGLDPFSRDQVWSLLRERRADHV-ILFSTQSMDEADILADRKVIMSNGRL 691
Query: 2468 QCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPV 2527
+C GS +K R+G G+ + +H +N E +T F+ H P LK ++ L Y +P+
Sbjct: 692 KCAGSSMFLKRRWGLGYHLSLH-RNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPL 750
Query: 2528 -TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFI 2563
++F L+ + +T + +S +TL EVF+
Sbjct: 751 ERTNTFPDLFSDLD-KCSDQGVTGYDISMSTLNEVFM 786
Score = 162 bits (411), Expect = 3e-39
Identities = 106/314 (33%), Positives = 167/314 (53%), Gaps = 21/314 (6%)
Query: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVR 1417
K+A N++ EG I LLGPNGAGK+++I M++G+ +AG + + G +V
Sbjct: 1300 KIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVL 1353
Query: 1418 KNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVG 1477
++G C Q +VL+ LT +EHL +Y ++K K + R + L+ + V
Sbjct: 1354 GHLGYCPQENVLWPMLTLREHLEVYAAVK--GLRKADARLAIARLVSAFKLHEQLNVPVQ 1411
Query: 1478 TLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK--NKTARTIILSTH 1535
L+ G+ RKL ++L+G S V++LDEPSTG+DP ++ +W I T R ++L+TH
Sbjct: 1412 KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTH 1471
Query: 1536 HLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAV 1595
+L EAE L DR+A + G LRC GS +LK G Y L L K++ + T+
Sbjct: 1472 NLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQV-------TLVH 1524
Query: 1596 TAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDT 1655
T +++ P+A +E L Y LP L A+ + + N+ Y +S
Sbjct: 1525 TEILKL-FPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKH---NFNLEEYSLSQC 1580
Query: 1656 TVEEVFLNLTKESQ 1669
T+E+VFL L+KE +
Sbjct: 1581 TLEKVFLELSKEQE 1594
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 268 bits (686), Expect = 4e-71
Identities = 209/786 (26%), Positives = 379/786 (48%), Gaps = 70/786 (8%)
Query: 1014 NQIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPY---PCFMKDNFLTSVSYSLP 1070
++ + + F+ Q +I AIIE+ T + E + V + P + T
Sbjct: 171 SEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFC 230
Query: 1071 IVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILI 1130
I+ ++ +++ V ++ + M MMG+ + + +W + GF+L+ ++
Sbjct: 231 IISFSTFIYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMA 286
Query: 1131 IILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPF 1190
+I+K I+ T ++F F Y S+I +++L+SV + L+ + +I F+
Sbjct: 287 LIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLV--VFLLIVFWGI 344
Query: 1191 IVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSF 1250
+ + L L+ + LLSP AF+ + + + +P T F
Sbjct: 345 LGFPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLF 404
Query: 1251 GWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNG 1310
+++ D+ +Y ++ Y + P YG F + +W + ++N
Sbjct: 405 -----MLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQH--------GRANH 451
Query: 1311 LMFTNIMMQNTNPSASPEYMFSSNIEPE--PKDLTVGVALHGVTKIYGSKV----AVDNL 1364
++ N T+ +P F + PE K+ + + + K Y K A+ +
Sbjct: 452 VVLEN----ETDSDPTPNDCFEP-VSPEFCGKE---AIRIKNLKKEYAGKCERVEALKGV 503
Query: 1365 NLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGV 1422
+ YEG IT+LLG +GAGKTT +++L+GL ++G++ VY + D+ + K G
Sbjct: 504 VFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGF 563
Query: 1423 CMQHDVLFSYLTTKEHLLLYGSIK--VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLS 1480
C Q +V F +LT KE+L L+ IK +PH ++ +EV+R +++ + + + LS
Sbjct: 564 CPQSNVQFGFLTVKENLRLFAKIKGILPH----EVEKEVQRVVQELEMENIQDILAQNLS 619
Query: 1481 GGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEA 1540
GG RKL+ IA++G +V++LDEP+ G+DP SR IW+++ + K+ R I+ ST +DEA
Sbjct: 620 GGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEA 679
Query: 1541 EVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQ 1600
++L+DR F+ G L+C GS +LK+ +G GYHL +L+ N CD ++T++++
Sbjct: 680 DILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL--------SLHLNERCDPESITSLVK 731
Query: 1601 SHLPEAYLKEDIGGELVYVLPPFST-KVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEE 1659
H+ +A L +LVY+LP T K Y L R + G+ D YG+S TT+ E
Sbjct: 732 QHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIED-----YGVSITTLNE 786
Query: 1660 VFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERL 1719
VFL L +S + + + ++ A I + +L S+F + TR + +
Sbjct: 787 VFLKLEGKSTIDES---DIGIWGQLQTDGAKDIGSLVELEQVLSSFHE------TR-KTI 836
Query: 1720 DGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVIL-PIVFVTTAMGLGTLRNSSNSYPEIQ 1778
G L +++ AI RF ++ K L ++L I F+ + + SYP +
Sbjct: 837 SGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYP-WE 895
Query: 1779 ISPSLY 1784
+SP+ Y
Sbjct: 896 LSPNTY 901
Score = 233 bits (595), Expect = 1e-60
Identities = 182/599 (30%), Positives = 297/599 (49%), Gaps = 60/599 (10%)
Query: 2002 ASFVTYV----VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFK 2057
ASF Y+ + +++ KA ISG+ + YW + D+ Y F I ++
Sbjct: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLY-----FLILLLMQIM 1088
Query: 2058 LPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLF------FGI 2111
F E + + LL+ +L + + + + F+TYV +F GI
Sbjct: 1089 DYIFSPEEIIFIIQNLLI----------QILCSIGYVSSLVFLTYVISFIFRNGRKNSGI 1138
Query: 2112 NSIVSLSVVYF--LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFL 2169
S L VV F ++ + L L T+ LI P G I +D+L
Sbjct: 1139 WSFFFLIVVIFSIVATDLNEYGFLGLFFGTM----LIPPFTLIGSLFIFSEISPDSMDYL 1194
Query: 2170 KAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHV-- 2227
A E + L + + + L + + L++K +F S+ +
Sbjct: 1195 GASESEIVYLALLIPYLHFLIFLFILR-----CLEMNCRKKLMRKDPVFRISPRSNAIFP 1249
Query: 2228 --RETIDEDEDVRAERLRVESGAA--EFD---LVQLYCLTKTYQ-------LIHKKIIAV 2273
E E+ED++ ER+R + A +FD ++ CL K Y KK IA
Sbjct: 1250 NPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIAT 1309
Query: 2274 NNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLV 2333
N+S + GE GLLG NGAGK+T KM+TGD P++G ++++ G +
Sbjct: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG-----EPLGFL 1364
Query: 2334 GYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYG 2393
GYCPQE+AL +TV +HL YA V G+ + D + +L+ L L S G
Sbjct: 1365 GYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEG 1424
Query: 2394 TKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSVILTSHSMEEC 2452
KRKL L+++G PS++LLDEPS+GMDP+ ++ +W++I +N + +LT+H M E
Sbjct: 1425 IKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEA 1484
Query: 2453 EALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTY 2512
EA+C R+AIMV+G+ +CIGS+QH+KS+FG+ + +++ LK N ME L + FP+
Sbjct: 1485 EAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLK-NLAQMEPLHAEILRLFPQAA 1543
Query: 2513 LKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQK 2570
+++ S++ Y +PV ++ F LE K + ++ + +SQ+TLE+VF+ +K+Q+
Sbjct: 1544 QQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQE 1602
Score = 162 bits (409), Expect = 5e-39
Identities = 139/598 (23%), Positives = 272/598 (45%), Gaps = 52/598 (8%)
Query: 1989 VALSILMGYSVTTASFVTYVVREHQTKAKQ----LQHISGIGVTCYWVTNFIYDMVFYLV 2044
VA + + + + S Y V + T+ +Q L + G+ + +W++ + F L+
Sbjct: 221 VATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILI 280
Query: 2045 PVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVC 2104
I+ ++ V L LL+G + + +L++ L + + +
Sbjct: 281 MATLMALIVKSAQIVVL---TGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFL 337
Query: 2105 VNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQS 2164
+ +F+GI +L + L+ + F F G+ +L
Sbjct: 338 LIVFWGILGFPALYT---------------RLPAFLEWTLCLLSPFAFTVGMAQLIH--- 379
Query: 2165 VLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESL------------I 2212
LD+ + + +F+ LV ++ L L ++ L
Sbjct: 380 -LDYDVNSNAHLDSSQNPYLIIATLFM-LVFDTLLYLVLTLYFDKILPAEYGHRCSPLFF 437
Query: 2213 KKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHKK 2269
K +F+ ++HV + D D E + EF + +++ L K Y ++
Sbjct: 438 LKSCFWFQHGRANHVVLENETDSDPTPNDC-FEPVSPEFCGKEAIRIKNLKKEYAGKCER 496
Query: 2270 IIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGS-LGHVDS 2328
+ A+ + I G+ LLG +GAGKTT+ +L+G +P+SG++ + N T S + +++
Sbjct: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
Query: 2329 HSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATS 2388
S G+CPQ + +TV+E+L +A++ GI ++++ V ++++ L + +D
Sbjct: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQ 616
Query: 2389 MCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHS 2448
S G RKL+ +A++G P +LLLDEP++G+DP S+ +W ++ E ++ ++ ++
Sbjct: 617 NLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRV-ILFSTQF 675
Query: 2449 MEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHF 2508
++E + L R + NGK +C GS +K ++G G+ + +HL N + E++T ++ H
Sbjct: 676 IDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHL-NERCDPESITSLVKQHI 734
Query: 2509 PKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALN---ITNFLVSQTTLEEVFI 2563
L Q L Y +P+ N F L + + I ++ VS TTL EVF+
Sbjct: 735 SDAKLTAQSEEKLVYILPLER---TNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFL 789
Score = 155 bits (391), Expect = 6e-37
Identities = 162/622 (26%), Positives = 268/622 (43%), Gaps = 77/622 (12%)
Query: 1077 WVVFIAAFVKKLV------YEKDLRLHEYMKMMGVNSCSHFFAWLIESVG-FLLVTIVIL 1129
W+ A+F + Y+K + H +++ G+ +++F + V + L+ +++
Sbjct: 1029 WIPMAASFTPYIAMSSIGDYKK--KAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQ 1086
Query: 1130 IIILKFGN---ILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIA 1186
I+ F I N I L Y S++ ++Y+IS F N + I S ++I
Sbjct: 1087 IMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIV 1146
Query: 1187 FFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDD 1246
F ++ T NE ++ F ++L P S +I + + +
Sbjct: 1147 VI-FSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFI-----------FSEISPDSMDYL 1194
Query: 1247 TTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYG---MAAPWYFPILPSYWKERFGCAEV 1303
S + L L +++FLI ++ M F I P R
Sbjct: 1195 GASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISP-----RSNAIFP 1249
Query: 1304 KPEKSNGLMFTNIM--MQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSK--- 1358
PE+ G M M+ N A ++ D T + + K Y K
Sbjct: 1250 NPEEPEGEEEDIQMERMRTVNAMAVRDF-----------DETPVIIASCLRKEYAGKKKN 1298
Query: 1359 --------VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK 1410
+A N++ +G + LLG NGAGK+TTI M+TG +AG + + G
Sbjct: 1299 CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG 1358
Query: 1411 TDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYS 1470
L +G C Q + L+ LT ++HL +Y ++K K + R + L
Sbjct: 1359 EPLGF----LGYCPQENALWPNLTVRQHLEVYAAVK--GLRKGDAMIAITRLVDALKLQD 1412
Query: 1471 HRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVI--SKNKTAR 1528
V TLS G+KRKL ++++G VV+LDEPSTG+DP ++ +W VI + T R
Sbjct: 1413 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTER 1472
Query: 1529 TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANA 1588
+L+TH++ EAE + DR+A + G LRC GS +LK FG Y L + K +
Sbjct: 1473 GALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQME--- 1529
Query: 1589 VCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTK-VSGAYLSLLRALDNGMGDLNI 1647
+ A I P+A +E +VY LP + +S A+ L+ ++
Sbjct: 1530 -----PLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFK----LEIVKQSFDL 1580
Query: 1648 GCYGISDTTVEEVFLNLTKESQ 1669
Y +S +T+E+VFL L+KE +
Sbjct: 1581 EEYSLSQSTLEQVFLELSKEQE 1602
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 236 bits (602), Expect = 2e-61
Identities = 176/662 (26%), Positives = 312/662 (47%), Gaps = 88/662 (13%)
Query: 1021 FIYLQDSIERAIIELQTGRNSQE--IAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWV 1078
F+ LQ +I AIIE+ T + E ++V + + F+ + + + Y ++ +
Sbjct: 177 FVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSF 236
Query: 1079 VFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNI 1138
++ A+ V + R+ M MMG+ + + +W + GF+ + + L ++++
Sbjct: 237 IYYASVN---VTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQF 293
Query: 1139 LPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVEN 1198
+ + ++F F Y S++A+++L+S+ + + L+ L+ + F+ + ++
Sbjct: 294 IILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTV--FWGCLGFTSLYR 351
Query: 1199 ELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLIL 1258
L L+ +SLLSP AF + + N P D ++ +L
Sbjct: 352 HLPASLEWILSLLSPFAFMLGMAQLLHLDYD------LNSNAFPHPSDGSNLIVATNFML 405
Query: 1259 A-DSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIM 1317
A D+ +Y +A Y + P YG P F + S+W + +K++ + + M
Sbjct: 406 AFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQT--------QKTDHVALEDEM 457
Query: 1318 MQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKV----AVDNLNLNFYEGHI 1373
A P + S P + + VTK Y K A+ +L + YEG I
Sbjct: 458 ------DADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQI 511
Query: 1374 TSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGVCMQHDVLFS 1431
T++LG +GAGK+T +++L+GL + G++ +Y + DL + K GVC Q +V F
Sbjct: 512 TAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFD 571
Query: 1432 YLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISI 1491
+LT +E+L L+ I K L +EV +
Sbjct: 572 FLTVRENLRLFAKI------KGILPQEVDK------------------------------ 595
Query: 1492 ALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLE 1551
+ +LDEP+ G+DP SR +W+++ + KT R I+ ST +DEA++L+DR FL
Sbjct: 596 ------EIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLS 649
Query: 1552 QGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKED 1611
QG L+C GS +LK+ +G GYHL +L N +C +T++++ H+P+A L
Sbjct: 650 QGKLKCAGSSLFLKKKWGIGYHL--------SLQLNEICVEENITSLVKQHIPDAKLSAK 701
Query: 1612 IGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKN 1671
G+L+Y LP + + + L + LD+ DL I YG+S TT+ EVFL L +S N
Sbjct: 702 SEGKLIYTLP---LERTNKFPELYKDLDS-YPDLGIENYGVSMTTLNEVFLKLEGKSTIN 757
Query: 1672 SA 1673
+
Sbjct: 758 ES 759
Score = 226 bits (576), Expect = 2e-58
Identities = 177/609 (29%), Positives = 298/609 (48%), Gaps = 60/609 (9%)
Query: 1991 LSILMGYSVTTASFVTYV----VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPV 2046
L+ +M + V T+S Y+ + +++ +A+ ISG+ + YW + D+ Y +
Sbjct: 982 LAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVF 1041
Query: 2047 AFSIGIIAIFKLPAFYSENNLGAVSLLLL--LFGYATFSWMYLLAGLFHETGMAFITYVC 2104
F I + + + + L + ++ + GY+ FS + F+TYV
Sbjct: 1042 VF----IYLMSYISNFEDMLLTIIHIIQIPCAVGYS-FS-------------LIFMTYVI 1083
Query: 2105 VNLFFG--INSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQ 2162
+F NS + Y ++ + + IF G + LS
Sbjct: 1084 SFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSH 1143
Query: 2163 QSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL--FFR 2220
+ + E ++ + + F+LR L + K +R FFR
Sbjct: 1144 L-------LFSSLFSEERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFR 1196
Query: 2221 -KFNSSHV----RETIDEDEDVRAERLRVESG--AAEFD---LVQLYCLTKTYQ------ 2264
SS V E EDEDV+ ER+R + + FD ++ CL K Y
Sbjct: 1197 ISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGC 1256
Query: 2265 -LIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSL 2323
K IA N+S + GE GLLG NGAGK+T K++TGD P++G +L++ G
Sbjct: 1257 FSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGG- 1315
Query: 2324 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFK 2383
+GYCPQE+AL +TV +HL YA V G+ + D + + +L+ L L
Sbjct: 1316 ----DALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQL 1371
Query: 2384 DRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSV 2442
S G KRKL L+++G PS++LLDEPS+GMDP+ ++ +W+ I +N +
Sbjct: 1372 KSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGA 1431
Query: 2443 ILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTK 2502
+LT+H M E EA+C R+AIMV+G+ +CIGS+QH+KS+FG+ + +++ +KN +
Sbjct: 1432 LLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAE 1491
Query: 2503 FMQLHFPKTYLKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEV 2561
++L FP+ ++++ S++ Y +PV +A F LE K + ++ + +SQ+TLE+V
Sbjct: 1492 ILRL-FPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQV 1550
Query: 2562 FINFAKDQK 2570
F+ +K+Q+
Sbjct: 1551 FLELSKEQE 1559
Score = 159 bits (403), Expect = 3e-38
Identities = 152/596 (25%), Positives = 270/596 (45%), Gaps = 67/596 (11%)
Query: 1095 RLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILII---ILKFGNILPKTNGFILFLYF 1151
R +++ G++ +++F + V + V + + I F ++L I
Sbjct: 1010 RARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCA 1069
Query: 1152 SDYSFSVIAMSYLISVFFNNTNIAALIGSL------IYIIAFFPFIVLVTVENELSYVLK 1205
YSFS+I M+Y+IS F + I S ++ +A F F + E+++ ++
Sbjct: 1070 VGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIF---ESDIPFIF- 1125
Query: 1206 VFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYF 1265
+ L P A +++ + L + +++ S + D F L+ F++F
Sbjct: 1126 ---TFLIPPATMIGCLFLSSH------LLFSSLF-SEERMDVQPF-----LVFLIPFLHF 1170
Query: 1266 LIAWYVRNVFPGTYG---MAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTN 1322
+I + +G M +F I P R PE+ G ++ M+
Sbjct: 1171 IIFLFTLRCLEWKFGKKSMRKDPFFRISP-----RSSDVCQNPEEPEG-EDEDVQMERVR 1224
Query: 1323 PSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYG------SKVAVDNLNLNFYEGHITSL 1376
+ + + S+N + +P + + K G +K+A N++ +G + L
Sbjct: 1225 TANA---LNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGL 1281
Query: 1377 LGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTK 1436
LG NGAGK+T+I ++TG +AG + + G L +G C Q + L+ LT +
Sbjct: 1282 LGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF----LGYCPQENALWPNLTVR 1337
Query: 1437 EHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGG 1496
+HL +Y ++K K + R + L V TLS G+KRKL ++++G
Sbjct: 1338 QHLEVYAAVK--GLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGN 1395
Query: 1497 SRVVILDEPSTGVDPCSRRSIWDVI--SKNKTARTIILSTHHLDEAEVLSDRIAFLEQGG 1554
VV+LDEPSTG+DP ++ +W I + T R +L+TH++ EAE + DR+A + G
Sbjct: 1396 PSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGR 1455
Query: 1555 LRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGG 1614
LRC GS +LK FG Y L + K + + A I P+A +E
Sbjct: 1456 LRCIGSIQHLKSKFGKDYLLEMKVKN--------LAQVEPLHAEILRLFPQAARQERYSS 1507
Query: 1615 ELVYVLPPFSTK-VSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQ 1669
+VY LP + ++ A+ L + + ++ Y +S +T+E+VFL L+KE +
Sbjct: 1508 LMVYKLPVEDVQPLAQAFFKLEKVKQS----FDLEEYSLSQSTLEQVFLELSKEQE 1559
Score = 140 bits (353), Expect = 2e-32
Identities = 147/638 (23%), Positives = 273/638 (42%), Gaps = 109/638 (17%)
Query: 1982 SSLIDILVALSILMGYSVTTASFVTYV---VREHQTKAKQLQHISGIGVTCYWVT----- 2033
S +I L S ++ +S SF+ Y V + + K L + G+ + +W++
Sbjct: 218 SGVITDLYLFSCIISFS----SFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLY 273
Query: 2034 -NFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLF 2092
FI+ M +L V S I + +S L LL+G + + +L++ L
Sbjct: 274 AGFIFIMALFLALVIRSTQFIILSGFMVVFS---------LFLLYGLSLVALAFLMSILV 324
Query: 2093 HETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCF 2152
++ + + + +F+G SL + +L+ I + F F
Sbjct: 325 KKSFLTGLVVFLLTVFWGCLGFTSL---------------YRHLPASLEWILSLLSPFAF 369
Query: 2153 GYGLIELSQQQSVLDF-LKAYGVEYPNETFEM----NKLGAMFVALVSQGTMFFSLRLLI 2207
G+ +L LD+ L + +P++ + N + A L ++F ++L
Sbjct: 370 MLGMAQLLH----LDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE-KILP 424
Query: 2208 NESLIKKLRLFFRKFN-------SSHVRETIDEDEDVRAERLRVESGAAEF---DLVQLY 2257
NE ++ LFF K + + HV + D D E EF + +++
Sbjct: 425 NEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHD-SFEQAPPEFQGKEAIRIR 483
Query: 2258 CLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILI- 2316
+TK Y+ KI A+ ++ I G+ +LG +GAGK+T+ +L+G +P+ G++ I
Sbjct: 484 NVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIY 543
Query: 2317 RNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRR 2376
NK + +++ S L G CPQ + D +TV E+L +A++ GI +++ +
Sbjct: 544 NNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDK-------- 595
Query: 2377 LHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEV 2436
I LLDEP++G+DP S+ +W ++ E
Sbjct: 596 --------------------------------EIFLLDEPTAGLDPFSRHQVWNLLKERK 623
Query: 2437 QNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVT 2496
++ ++ ++ M+E + L R + GK +C GS +K ++G G+ + + L N
Sbjct: 624 TDRV-ILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQL-NEICV 681
Query: 2497 METLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTA---LNITNFLV 2553
E +T ++ H P L + L Y +P+ N F L + + L I N+ V
Sbjct: 682 EENITSLVKQHIPDAKLSAKSEGKLIYTLPLER---TNKFPELYKDLDSYPDLGIENYGV 738
Query: 2554 SQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDD 2591
S TTL EVF+ + + + +D + G + + DD
Sbjct: 739 SMTTLNEVFLKL-EGKSTINESDIAILGE-VQAEKADD 774
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 146 bits (368), Expect = 3e-34
Identities = 73/164 (44%), Positives = 109/164 (66%), Gaps = 1/164 (0%)
Query: 2346 VTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALI 2405
+T +E + YAR+ G+ E I V+K L L L R + S G KR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2406 GKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNG 2465
G+ S++ LDEPS+GMDP ++R LW ++++ ++ ++++TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2466 KFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFP 2509
KF C+GS QH+KS+FG + +KV +K +E ++ FP
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTED-KLEDFKCYVATTFP 163
Score = 104 bits (260), Expect = 1e-21
Identities = 56/155 (36%), Positives = 93/155 (60%), Gaps = 7/155 (4%)
Query: 1433 LTTKEHLLLYGSIKVPHW--TKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSIS 1490
+T +E +++Y I W ++ Q+ V + L L SH + + T S G KR+LS +
Sbjct: 1 MTAQEIMIMYARI----WGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTA 56
Query: 1491 IALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNK-TARTIILSTHHLDEAEVLSDRIAF 1549
IAL+G S V+ LDEPSTG+DP +RR +W++++K + + + I++++H ++E + L +A
Sbjct: 57 IALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAI 116
Query: 1550 LEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNL 1584
+ QG C GSP +LK FG+ Y L + K L
Sbjct: 117 MVQGKFTCLGSPQHLKSKFGNIYILKVKVKTEDKL 151
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 146 bits (368), Expect = 3e-34
Identities = 73/164 (44%), Positives = 109/164 (66%), Gaps = 1/164 (0%)
Query: 2346 VTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALI 2405
+T +E + YAR+ G+ E I V+K L L L R + S G KR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2406 GKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNG 2465
G+ S++ LDEPS+GMDP ++R LW ++++ ++ ++++TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2466 KFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFP 2509
KF C+GS QH+KS+FG + +KV +K +E ++ FP
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTED-KLEDFKCYVATTFP 163
Score = 104 bits (260), Expect = 1e-21
Identities = 56/155 (36%), Positives = 93/155 (60%), Gaps = 7/155 (4%)
Query: 1433 LTTKEHLLLYGSIKVPHW--TKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSIS 1490
+T +E +++Y I W ++ Q+ V + L L SH + + T S G KR+LS +
Sbjct: 1 MTAQEIMIMYARI----WGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTA 56
Query: 1491 IALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNK-TARTIILSTHHLDEAEVLSDRIAF 1549
IAL+G S V+ LDEPSTG+DP +RR +W++++K + + + I++++H ++E + L +A
Sbjct: 57 IALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAI 116
Query: 1550 LEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNL 1584
+ QG C GSP +LK FG+ Y L + K L
Sbjct: 117 MVQGKFTCLGSPQHLKSKFGNIYILKVKVKTEDKL 151
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 146 bits (368), Expect = 3e-34
Identities = 73/164 (44%), Positives = 109/164 (66%), Gaps = 1/164 (0%)
Query: 2346 VTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALI 2405
+T +E + YAR+ G+ E I V+K L L L R + S G KR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2406 GKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNG 2465
G+ S++ LDEPS+GMDP ++R LW ++++ ++ ++++TSHSMEEC+ALCT LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2466 KFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFP 2509
KF C+GS QH+KS+FG + +KV +K +E ++ FP
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTED-KLEDFKCYVATTFP 163
Score = 104 bits (260), Expect = 1e-21
Identities = 56/155 (36%), Positives = 93/155 (60%), Gaps = 7/155 (4%)
Query: 1433 LTTKEHLLLYGSIKVPHW--TKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSIS 1490
+T +E +++Y I W ++ Q+ V + L L SH + + T S G KR+LS +
Sbjct: 1 MTAQEIMIMYARI----WGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTA 56
Query: 1491 IALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNK-TARTIILSTHHLDEAEVLSDRIAF 1549
IAL+G S V+ LDEPSTG+DP +RR +W++++K + + + I++++H ++E + L +A
Sbjct: 57 IALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAI 116
Query: 1550 LEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNL 1584
+ QG C GSP +LK FG+ Y L + K L
Sbjct: 117 MVQGKFTCLGSPQHLKSKFGNIYILKVKVKTEDKL 151
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 90.9 bits (224), Expect = 1e-17
Identities = 63/219 (28%), Positives = 112/219 (51%), Gaps = 6/219 (2%)
Query: 1338 EPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1397
E +DL+ V + G K + ++ F G + +++GP+GAGK+T +++L G
Sbjct: 75 EFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRET 134
Query: 1398 SA-GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLH 1456
G + + G + DL RK MQ D+L +LT +E +++ +K+ + +
Sbjct: 135 GMKGAVLING--LPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR-R 191
Query: 1457 EEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1516
E VK L GL S + R G+LSGG +++L+I++ L+ V+ DEP++G+D S
Sbjct: 192 EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 251
Query: 1517 IWDVISKNKTARTIILSTHHLDEAEV--LSDRIAFLEQG 1553
+ ++ I+ T H A++ L D++ L QG
Sbjct: 252 VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQG 290
Score = 66.2 bits (160), Expect = 4e-10
Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTG-DIIPSSGNILIRNKTGSLGHVDSHSS 2331
+ IS +GE ++G +GAGK+T+ +L G G +LI L S
Sbjct: 98 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 157
Query: 2332 LVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDI--KETVHKLLRRLHLMPFKDRATSM 2389
Y Q+D L +TV+E + A + + EKD +E V ++L L L+ + T
Sbjct: 158 ---YIMQDDMLLPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGS 213
Query: 2390 CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
S G +++L+ AL L+ P ++ DEP+SG+D S + ++ Q S+I T H
Sbjct: 214 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 271
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 90.9 bits (224), Expect = 1e-17
Identities = 63/219 (28%), Positives = 112/219 (51%), Gaps = 6/219 (2%)
Query: 1338 EPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1397
E +DL+ V + G K + ++ F G + +++GP+GAGK+T +++L G
Sbjct: 56 EFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRET 115
Query: 1398 SA-GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLH 1456
G + + G + DL RK MQ D+L +LT +E +++ +K+ + +
Sbjct: 116 GMKGAVLING--LPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR-R 172
Query: 1457 EEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1516
E VK L GL S + R G+LSGG +++L+I++ L+ V+ DEP++G+D S
Sbjct: 173 EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 232
Query: 1517 IWDVISKNKTARTIILSTHHLDEAEV--LSDRIAFLEQG 1553
+ ++ I+ T H A++ L D++ L QG
Sbjct: 233 VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQG 271
Score = 66.2 bits (160), Expect = 4e-10
Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTG-DIIPSSGNILIRNKTGSLGHVDSHSS 2331
+ IS +GE ++G +GAGK+T+ +L G G +LI L S
Sbjct: 79 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 138
Query: 2332 LVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDI--KETVHKLLRRLHLMPFKDRATSM 2389
Y Q+D L +TV+E + A + + EKD +E V ++L L L+ + T
Sbjct: 139 ---YIMQDDMLLPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGS 194
Query: 2390 CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
S G +++L+ AL L+ P ++ DEP+SG+D S + ++ Q S+I T H
Sbjct: 195 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 252
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 90.9 bits (224), Expect = 1e-17
Identities = 63/219 (28%), Positives = 112/219 (51%), Gaps = 6/219 (2%)
Query: 1338 EPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1397
E +DL+ V + G K + ++ F G + +++GP+GAGK+T +++L G
Sbjct: 80 EFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRET 139
Query: 1398 SA-GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLH 1456
G + + G + DL RK MQ D+L +LT +E +++ +K+ + +
Sbjct: 140 GMKGAVLING--LPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR-R 196
Query: 1457 EEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1516
E VK L GL S + R G+LSGG +++L+I++ L+ V+ DEP++G+D S
Sbjct: 197 EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 256
Query: 1517 IWDVISKNKTARTIILSTHHLDEAEV--LSDRIAFLEQG 1553
+ ++ I+ T H A++ L D++ L QG
Sbjct: 257 VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQG 295
Score = 66.2 bits (160), Expect = 4e-10
Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTG-DIIPSSGNILIRNKTGSLGHVDSHSS 2331
+ IS +GE ++G +GAGK+T+ +L G G +LI L S
Sbjct: 103 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 162
Query: 2332 LVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDI--KETVHKLLRRLHLMPFKDRATSM 2389
Y Q+D L +TV+E + A + + EKD +E V ++L L L+ + T
Sbjct: 163 ---YIMQDDMLLPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGS 218
Query: 2390 CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
S G +++L+ AL L+ P ++ DEP+SG+D S + ++ Q S+I T H
Sbjct: 219 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 276
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 90.9 bits (224), Expect = 1e-17
Identities = 63/219 (28%), Positives = 112/219 (51%), Gaps = 6/219 (2%)
Query: 1338 EPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1397
E +DL+ V + G K + ++ F G + +++GP+GAGK+T +++L G
Sbjct: 89 EFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRET 148
Query: 1398 SA-GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLH 1456
G + + G + DL RK MQ D+L +LT +E +++ +K+ + +
Sbjct: 149 GMKGAVLING--LPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR-R 205
Query: 1457 EEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1516
E VK L GL S + R G+LSGG +++L+I++ L+ V+ DEP++G+D S
Sbjct: 206 EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 265
Query: 1517 IWDVISKNKTARTIILSTHHLDEAEV--LSDRIAFLEQG 1553
+ ++ I+ T H A++ L D++ L QG
Sbjct: 266 VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQG 304
Score = 66.2 bits (160), Expect = 4e-10
Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTG-DIIPSSGNILIRNKTGSLGHVDSHSS 2331
+ IS +GE ++G +GAGK+T+ +L G G +LI L S
Sbjct: 112 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 171
Query: 2332 LVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDI--KETVHKLLRRLHLMPFKDRATSM 2389
Y Q+D L +TV+E + A + + EKD +E V ++L L L+ + T
Sbjct: 172 ---YIMQDDMLLPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGS 227
Query: 2390 CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
S G +++L+ AL L+ P ++ DEP+SG+D S + ++ Q S+I T H
Sbjct: 228 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 90.9 bits (224), Expect = 1e-17
Identities = 63/219 (28%), Positives = 112/219 (51%), Gaps = 6/219 (2%)
Query: 1338 EPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1397
E +DL+ V + G K + ++ F G + +++GP+GAGK+T +++L G
Sbjct: 78 EFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRET 137
Query: 1398 SA-GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLH 1456
G + + G + DL RK MQ D+L +LT +E +++ +K+ + +
Sbjct: 138 GMKGAVLING--LPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR-R 194
Query: 1457 EEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1516
E VK L GL S + R G+LSGG +++L+I++ L+ V+ DEP++G+D S
Sbjct: 195 EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 254
Query: 1517 IWDVISKNKTARTIILSTHHLDEAEV--LSDRIAFLEQG 1553
+ ++ I+ T H A++ L D++ L QG
Sbjct: 255 VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQG 293
Score = 66.2 bits (160), Expect = 4e-10
Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTG-DIIPSSGNILIRNKTGSLGHVDSHSS 2331
+ IS +GE ++G +GAGK+T+ +L G G +LI L S
Sbjct: 101 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 160
Query: 2332 LVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDI--KETVHKLLRRLHLMPFKDRATSM 2389
Y Q+D L +TV+E + A + + EKD +E V ++L L L+ + T
Sbjct: 161 ---YIMQDDMLLPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGS 216
Query: 2390 CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
S G +++L+ AL L+ P ++ DEP+SG+D S + ++ Q S+I T H
Sbjct: 217 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 90.9 bits (224), Expect = 1e-17
Identities = 63/219 (28%), Positives = 112/219 (51%), Gaps = 6/219 (2%)
Query: 1338 EPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1397
E +DL+ V + G K + ++ F G + +++GP+GAGK+T +++L G
Sbjct: 78 EFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRET 137
Query: 1398 SA-GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLH 1456
G + + G + DL RK MQ D+L +LT +E +++ +K+ + +
Sbjct: 138 GMKGAVLING--LPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR-R 194
Query: 1457 EEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1516
E VK L GL S + R G+LSGG +++L+I++ L+ V+ DEP++G+D S
Sbjct: 195 EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 254
Query: 1517 IWDVISKNKTARTIILSTHHLDEAEV--LSDRIAFLEQG 1553
+ ++ I+ T H A++ L D++ L QG
Sbjct: 255 VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQG 293
Score = 66.2 bits (160), Expect = 4e-10
Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTG-DIIPSSGNILIRNKTGSLGHVDSHSS 2331
+ IS +GE ++G +GAGK+T+ +L G G +LI L S
Sbjct: 101 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 160
Query: 2332 LVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDI--KETVHKLLRRLHLMPFKDRATSM 2389
Y Q+D L +TV+E + A + + EKD +E V ++L L L+ + T
Sbjct: 161 ---YIMQDDMLLPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGS 216
Query: 2390 CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
S G +++L+ AL L+ P ++ DEP+SG+D S + ++ Q S+I T H
Sbjct: 217 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 87.0 bits (214), Expect = 2e-16
Identities = 61/202 (30%), Positives = 102/202 (50%), Gaps = 22/202 (10%)
Query: 1364 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT-DLHTVRKNMGV 1422
LNL G +L+G +G GK+TT+ ++ L+ GTI + G+DI+ +++ +R+ +GV
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGV 474
Query: 1423 CMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHK-------- 1474
Q VLFS TT + YG V +E+K+ +K+ Y K
Sbjct: 475 VSQEPVLFS--TTIAENICYGRGNVTM-------DEIKKAVKEANAYEFIMKLPQKFDTL 525
Query: 1475 ---RVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTII 1531
R LSGG K++++I+ AL+ ++++LDE ++ +D S + + K + RT I
Sbjct: 526 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTI 585
Query: 1532 LSTHHLDEAEVLSDRIAFLEQG 1553
+ H L +D IA E G
Sbjct: 586 VIAHRLSTVR-NADVIAGFEDG 606
Score = 69.3 bits (168), Expect = 5e-11
Identities = 58/243 (23%), Positives = 116/243 (47%), Gaps = 27/243 (11%)
Query: 1361 VDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFV-YGKDI-------KTD 1412
+ L+L +G +L+G +G GK+T + +L + AGT+FV +G + K +
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLN 1111
Query: 1413 LHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYS-- 1470
+ +R +G+ Q +LF + + YG ++ +E+ K ++
Sbjct: 1112 VQWLRAQLGIVSQEPILFDCSIAEN--IAYGDN-----SRVVSQDEIVSAAKAANIHPFI 1164
Query: 1471 ----HRHK-RVGT----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVI 1521
H+++ RVG LSGG K++++I+ ALI ++++LDE ++ +D S + + + +
Sbjct: 1165 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1224
Query: 1522 SKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKS 1581
K + RT I+ H L + +D I + G ++ G+ L G + + + +
Sbjct: 1225 DKAREGRTCIVIAHRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT 1283
Query: 1582 PNL 1584
NL
Sbjct: 1284 QNL 1286
Score = 55.5 bits (132), Expect = 7e-07
Identities = 40/178 (22%), Positives = 83/178 (46%), Gaps = 8/178 (4%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2332
+ +++ + +G+ L+G +G GK+T +++ P G I I + +V+ +
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 2333 VGYCPQEDALDDLVTVEEHLYFYARV------HGIPEKDIKETVHKLLRRLHLMPFKDRA 2386
+G QE L E Y V + E + E + KL ++ + + A
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 2387 TSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVIL 2444
S G K++++ A AL+ P ILLLDE +S +D +S+ + + + + + ++++
Sbjct: 532 --QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVI 587
Score = 54.7 bits (130), Expect = 1e-06
Identities = 50/232 (21%), Positives = 112/232 (48%), Gaps = 25/232 (10%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNI-------LIRNKTGSLGH 2325
+ +S+ + G+ L+G +G GK+T+ ++L P +G + L+ + +
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLN 1111
Query: 2326 VDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKET-----VHKLLRRLHLM 2380
V + +G QE L D ++ E++ + + + +I +H + L
Sbjct: 1112 VQWLRAQLGIVSQEPILFDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL--- 1167
Query: 2381 PFK------DRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISE 2434
P K D+ T + S G K++++ A ALI +P ILLLDE +S +D +S++ + + + +
Sbjct: 1168 PHKYETRVGDKGTQL-SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK 1226
Query: 2435 EVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTV 2486
+ + +++ +H + + + + NG+ + G+ Q + ++ G F++
Sbjct: 1227 AREGRTCIVI-AHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 87.0 bits (214), Expect = 2e-16
Identities = 61/202 (30%), Positives = 102/202 (50%), Gaps = 22/202 (10%)
Query: 1364 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT-DLHTVRKNMGV 1422
LNL G +L+G +G GK+TT+ ++ L+ GTI + G+DI+ +++ +R+ +GV
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGV 474
Query: 1423 CMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHK-------- 1474
Q VLFS TT + YG V +E+K+ +K+ Y K
Sbjct: 475 VSQEPVLFS--TTIAENICYGRGNVTM-------DEIKKAVKEANAYEFIMKLPQKFDTL 525
Query: 1475 ---RVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTII 1531
R LSGG K++++I+ AL+ ++++LDE ++ +D S + + K + RT I
Sbjct: 526 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTI 585
Query: 1532 LSTHHLDEAEVLSDRIAFLEQG 1553
+ H L +D IA E G
Sbjct: 586 VIAHRLSTVR-NADVIAGFEDG 606
Score = 71.6 bits (174), Expect = 9e-12
Identities = 56/236 (23%), Positives = 115/236 (48%), Gaps = 20/236 (8%)
Query: 1361 VDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT-DLHTVRKN 1419
+ L+L +G +L+G +G GK+T + +L + AGT+ + G++ K ++ +R
Sbjct: 1005 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ 1064
Query: 1420 MGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYS------HRH 1473
+G+ Q +LF + + YG ++ +E+ K ++ H++
Sbjct: 1065 LGIVSQEPILFDCSIAEN--IAYGDN-----SRVVSQDEIVSAAKAANIHPFIETLPHKY 1117
Query: 1474 K-RVGT----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTAR 1528
+ RVG LSGG K++++I+ ALI ++++LDE ++ +D S + + + + K + R
Sbjct: 1118 ETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR 1177
Query: 1529 TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNL 1584
T I+ H L + +D I + G ++ G+ L G + + + + NL
Sbjct: 1178 TCIVIAHRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL 1232
Score = 61.6 bits (148), Expect = 1e-08
Identities = 50/225 (22%), Positives = 112/225 (49%), Gaps = 18/225 (8%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2332
+ +S+ + G+ L+G +G GK+T+ ++L P +G +L+ + +V +
Sbjct: 1005 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ 1064
Query: 2333 VGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKET-----VHKLLRRLHLMPFK---- 2383
+G QE L D ++ E++ + + + +I +H + L P K
Sbjct: 1065 LGIVSQEPILFDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL---PHKYETR 1120
Query: 2384 --DRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCS 2441
D+ T + S G K++++ A ALI +P ILLLDE +S +D +S++ + + + + + +
Sbjct: 1121 VGDKGTQL-SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC 1179
Query: 2442 VILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTV 2486
+++ +H + + + + NG+ + G+ Q + ++ G F++
Sbjct: 1180 IVI-AHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
Score = 55.5 bits (132), Expect = 7e-07
Identities = 40/178 (22%), Positives = 83/178 (46%), Gaps = 8/178 (4%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2332
+ +++ + +G+ L+G +G GK+T +++ P G I I + +V+ +
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 2333 VGYCPQEDALDDLVTVEEHLYFYARV------HGIPEKDIKETVHKLLRRLHLMPFKDRA 2386
+G QE L E Y V + E + E + KL ++ + + A
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 2387 TSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVIL 2444
S G K++++ A AL+ P ILLLDE +S +D +S+ + + + + + ++++
Sbjct: 532 --QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVI 587
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 87.0 bits (214), Expect = 2e-16
Identities = 61/202 (30%), Positives = 102/202 (50%), Gaps = 22/202 (10%)
Query: 1364 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT-DLHTVRKNMGV 1422
LNL G +L+G +G GK+TT+ ++ L+ GTI + G+DI+ +++ +R+ +GV
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGV 474
Query: 1423 CMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHK-------- 1474
Q VLFS TT + YG V +E+K+ +K+ Y K
Sbjct: 475 VSQEPVLFS--TTIAENICYGRGNVTM-------DEIKKAVKEANAYEFIMKLPQKFDTL 525
Query: 1475 ---RVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTII 1531
R LSGG K++++I+ AL+ ++++LDE ++ +D S + + K + RT I
Sbjct: 526 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTI 585
Query: 1532 LSTHHLDEAEVLSDRIAFLEQG 1553
+ H L +D IA E G
Sbjct: 586 VIAHRLSTVR-NADVIAGFEDG 606
Score = 71.6 bits (174), Expect = 9e-12
Identities = 56/236 (23%), Positives = 115/236 (48%), Gaps = 20/236 (8%)
Query: 1361 VDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT-DLHTVRKN 1419
+ L+L +G +L+G +G GK+T + +L + AGT+ + G++ K ++ +R
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ 1111
Query: 1420 MGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYS------HRH 1473
+G+ Q +LF + + YG ++ +E+ K ++ H++
Sbjct: 1112 LGIVSQEPILFDCSIAEN--IAYGDN-----SRVVSQDEIVSAAKAANIHPFIETLPHKY 1164
Query: 1474 K-RVGT----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTAR 1528
+ RVG LSGG K++++I+ ALI ++++LDE ++ +D S + + + + K + R
Sbjct: 1165 ETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR 1224
Query: 1529 TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNL 1584
T I+ H L + +D I + G ++ G+ L G + + + + NL
Sbjct: 1225 TCIVIAHRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL 1279
Score = 61.6 bits (148), Expect = 1e-08
Identities = 50/225 (22%), Positives = 112/225 (49%), Gaps = 18/225 (8%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2332
+ +S+ + G+ L+G +G GK+T+ ++L P +G +L+ + +V +
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ 1111
Query: 2333 VGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKET-----VHKLLRRLHLMPFK---- 2383
+G QE L D ++ E++ + + + +I +H + L P K
Sbjct: 1112 LGIVSQEPILFDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL---PHKYETR 1167
Query: 2384 --DRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCS 2441
D+ T + S G K++++ A ALI +P ILLLDE +S +D +S++ + + + + + +
Sbjct: 1168 VGDKGTQL-SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC 1226
Query: 2442 VILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTV 2486
+++ +H + + + + NG+ + G+ Q + ++ G F++
Sbjct: 1227 IVI-AHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1269
Score = 55.5 bits (132), Expect = 7e-07
Identities = 40/178 (22%), Positives = 83/178 (46%), Gaps = 8/178 (4%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2332
+ +++ + +G+ L+G +G GK+T +++ P G I I + +V+ +
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 2333 VGYCPQEDALDDLVTVEEHLYFYARV------HGIPEKDIKETVHKLLRRLHLMPFKDRA 2386
+G QE L E Y V + E + E + KL ++ + + A
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 2387 TSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVIL 2444
S G K++++ A AL+ P ILLLDE +S +D +S+ + + + + + ++++
Sbjct: 532 --QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVI 587
>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 86.7 bits (213), Expect = 3e-16
Identities = 61/203 (30%), Positives = 104/203 (51%), Gaps = 10/203 (4%)
Query: 1356 GSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA-GTIFVYGKDIKTDLH 1414
G K + L+ F + ++GP+GAGK+T +++L G + G I V G+ +L
Sbjct: 80 GYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELR 137
Query: 1415 TVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHW--TKKQLHEEVKRTLKDTGLYSHR 1472
T RK MQ D+L +LT E +++ ++K+ KK+L E+ L GL S
Sbjct: 138 TFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTAL---GLMSCS 194
Query: 1473 HKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIIL 1532
H R LSGG +++L+I++ L+ V+ DEP++G+D S + ++ I+
Sbjct: 195 HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTII 254
Query: 1533 STHHLDEAEV--LSDRIAFLEQG 1553
T H A++ + D++ L QG
Sbjct: 255 CTIHQPSAKLFEMFDKLYILSQG 277
Score = 68.2 bits (165), Expect = 1e-10
Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 5/166 (3%)
Query: 2284 ECFGLLGVNGAGKTTIFKMLTGDIIPS-SGNILIRNKTGSLGHVDSHSSLVGYCPQEDAL 2342
E G++G +GAGK+T +L G G IL+ + L S Y Q+D L
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSC---YIMQDDML 152
Query: 2343 DDLVTVEEHLYFYARVHGIPEKDIK-ETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTA 2401
+TV E + A + ++++K E V ++L L LM T++ S G +++L+ A
Sbjct: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
Query: 2402 LALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
L L+ P ++ DEP+SG+D S + ++ Q ++I T H
Sbjct: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 86.7 bits (213), Expect = 3e-16
Identities = 61/203 (30%), Positives = 104/203 (51%), Gaps = 10/203 (4%)
Query: 1356 GSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA-GTIFVYGKDIKTDLH 1414
G K + L+ F + ++GP+GAGK+T +++L G + G I V G+ +L
Sbjct: 80 GYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELR 137
Query: 1415 TVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHW--TKKQLHEEVKRTLKDTGLYSHR 1472
T RK MQ D+L +LT E +++ ++K+ KK+L E+ L GL S
Sbjct: 138 TFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTAL---GLMSCS 194
Query: 1473 HKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIIL 1532
H R LSGG +++L+I++ L+ V+ DEP++G+D S + ++ I+
Sbjct: 195 HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTII 254
Query: 1533 STHHLDEAEV--LSDRIAFLEQG 1553
T H A++ + D++ L QG
Sbjct: 255 CTIHQPSAKLFEMFDKLYILSQG 277
Score = 68.2 bits (165), Expect = 1e-10
Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 5/166 (3%)
Query: 2284 ECFGLLGVNGAGKTTIFKMLTGDIIPS-SGNILIRNKTGSLGHVDSHSSLVGYCPQEDAL 2342
E G++G +GAGK+T +L G G IL+ + L S Y Q+D L
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSC---YIMQDDML 152
Query: 2343 DDLVTVEEHLYFYARVHGIPEKDIK-ETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTA 2401
+TV E + A + ++++K E V ++L L LM T++ S G +++L+ A
Sbjct: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
Query: 2402 LALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
L L+ P ++ DEP+SG+D S + ++ Q ++I T H
Sbjct: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 82.4 bits (202), Expect = 5e-15
Identities = 72/262 (27%), Positives = 125/262 (47%), Gaps = 26/262 (9%)
Query: 1346 VALHGVTKIYGSKVAV---DNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTI 1402
+ H VT Y S+ V ++LN+ G +T+L+GP+GAGK+T + ++ + G +
Sbjct: 420 IEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMV 479
Query: 1403 FVYGKDIKT-DLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKR 1461
V G DI++ ++ +R +G+ Q VLFS TT + YG + E++ +
Sbjct: 480 TVDGHDIRSLNIQWLRDQIGIVEQEPVLFS--TTIAENIRYGR-------EDATMEDIVQ 530
Query: 1462 TLKDTGLYSHRH-----------KRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVD 1510
K+ Y+ + G +SGG K++++I+ ALI ++++LD ++ +D
Sbjct: 531 AAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD 590
Query: 1511 PCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGD 1570
S + +V+SK + TII H L +D I E G G+ L E G
Sbjct: 591 NESEAMVQEVLSKIQHGHTIISVAHRLSTVRA-ADTIIGFEHGTAVERGTHEELLERKGV 649
Query: 1571 GYHL-TLTKKKSPNLNANAVCD 1591
+ L TL + + LN + D
Sbjct: 650 YFTLVTLQSQGNQALNEEDIKD 671
Score = 68.9 bits (167), Expect = 6e-11
Identities = 58/229 (25%), Positives = 108/229 (47%), Gaps = 20/229 (8%)
Query: 1361 VDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK-TDLHTVRKN 1419
++ L+++ G + +G +G GK+T+I +L + G + + G D K ++ +R N
Sbjct: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSN 1155
Query: 1420 MGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSH-------R 1472
+G+ Q VLF+ + +IK TK+ E V K L+
Sbjct: 1156 IGIVSQEPVLFA-------CSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKY 1208
Query: 1473 HKRVGT----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTAR 1528
VG+ LS G K++++I+ A++ ++++LDE ++ +D S +++ + K + R
Sbjct: 1209 ETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGR 1268
Query: 1529 TIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLT 1577
T I+ H L + +D IA + QG + G+ L G Y L T
Sbjct: 1269 TCIVIAHRLSTIQ-NADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
Score = 55.5 bits (132), Expect = 7e-07
Identities = 38/179 (21%), Positives = 82/179 (45%), Gaps = 8/179 (4%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2332
+N +S+ I G+ +G +G GK+T ++L P G ++I +V S
Sbjct: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSN 1155
Query: 2333 VGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRAT----- 2387
+G QE L ++ +++ + IP + + + +M ++
Sbjct: 1156 IGIVSQEPVLF-ACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGS 1214
Query: 2388 --SMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVIL 2444
S S G K++++ A A++ P ILLLDE +S +D +S++ + + + + + +++
Sbjct: 1215 QGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVI 1273
Score = 52.0 bits (123), Expect = 8e-06
Identities = 47/192 (24%), Positives = 91/192 (47%), Gaps = 11/192 (5%)
Query: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2332
+N++++ I GE L+G +GAGK+T +++ P G + + ++
Sbjct: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
Query: 2333 VGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMC-- 2390
+G QE L T+ E++ Y R E DI + + +M + ++
Sbjct: 498 IGIVEQEPVLFS-TTIAENIR-YGREDATME-DIVQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 2391 -----SYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILT 2445
S G K++++ A ALI P ILLLD +S +D +S+ + +++S ++Q+ ++I
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLS-KIQHGHTIISV 613
Query: 2446 SHSMEECEALCT 2457
+H + A T
Sbjct: 614 AHRLSTVRAADT 625
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,650,062
Number of Sequences: 37866
Number of extensions: 4067933
Number of successful extensions: 10532
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 9806
Number of HSP's gapped (non-prelim): 341
length of query: 2595
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2476
effective length of database: 13,741,464
effective search space: 34023864864
effective search space used: 34023864864
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.