Search of human proteins with 30089940

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo
sapiens]
         (1498 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]  2858   0.0  
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    213   9e-55
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        197   5e-50
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   187   5e-47
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   186   2e-46
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   186   2e-46
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   186   2e-46
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   186   2e-46
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       185   3e-46
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       185   3e-46
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        185   3e-46
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        185   3e-46
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        185   3e-46
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        185   3e-46
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        185   3e-46
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        185   3e-46
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            181   4e-45
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   179   2e-44
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   175   3e-43
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   175   3e-43
gi|21735548 centrosomal protein 2 [Homo sapiens]                      175   3e-43
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    174   8e-43
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      171   6e-42
gi|55770834 centromere protein F [Homo sapiens]                       170   8e-42
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   170   8e-42
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               170   1e-41
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   170   1e-41
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   169   1e-41
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   169   1e-41
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          169   2e-41

>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 2858 bits (7409), Expect = 0.0
 Identities = 1498/1498 (100%), Positives = 1498/1498 (100%)

Query: 1    MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLVPPDQQDKVQCAEVNRASTEGESPDG 60
            MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLVPPDQQDKVQCAEVNRASTEGESPDG
Sbjct: 1    MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLVPPDQQDKVQCAEVNRASTEGESPDG 60

Query: 61   PGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVRKEA 120
            PGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVRKEA
Sbjct: 61   PGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVRKEA 120

Query: 121  LQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATK 180
            LQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATK
Sbjct: 121  LQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATK 180

Query: 181  TRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKS 240
            TRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKS
Sbjct: 181  TRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKS 240

Query: 241  SKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENT 300
            SKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENT
Sbjct: 241  SKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENT 300

Query: 301  SLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPS 360
            SLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPS
Sbjct: 301  SLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPS 360

Query: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ 420
            IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ
Sbjct: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ 420

Query: 421  LEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDL 480
            LEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDL
Sbjct: 421  LEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDL 480

Query: 481  ERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQM 540
            ERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQM
Sbjct: 481  ERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQM 540

Query: 541  TALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQ 600
            TALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQ
Sbjct: 541  TALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQ 600

Query: 601  VGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQ 660
            VGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQ
Sbjct: 601  VGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQ 660

Query: 661  EAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHL 720
            EAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHL
Sbjct: 661  EAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHL 720

Query: 721  DLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEA 780
            DLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEA
Sbjct: 721  DLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEA 780

Query: 781  ALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            ALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK
Sbjct: 781  ALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAE 900
            IKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAE
Sbjct: 841  IKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAE 900

Query: 901  LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQI 960
            LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQI
Sbjct: 901  LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQI 960

Query: 961  EELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAA 1020
            EELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAA
Sbjct: 961  EELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAA 1020

Query: 1021 DAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESR 1080
            DAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESR
Sbjct: 1021 DAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESR 1080

Query: 1081 EKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILET 1140
            EKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILET
Sbjct: 1081 EKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILET 1140

Query: 1141 ALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKV 1200
            ALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKV
Sbjct: 1141 ALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKV 1200

Query: 1201 EAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAE 1260
            EAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAE
Sbjct: 1201 EAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAE 1260

Query: 1261 ARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG 1320
            ARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG
Sbjct: 1261 ARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG 1320

Query: 1321 LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAK 1380
            LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAK
Sbjct: 1321 LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAK 1380

Query: 1381 TRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMD 1440
            TRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMD
Sbjct: 1381 TRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMD 1440

Query: 1441 SLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQRHSQSRASKEGPGE 1498
            SLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQRHSQSRASKEGPGE
Sbjct: 1441 SLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQRHSQSRASKEGPGE 1498


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  213 bits (543), Expect = 9e-55
 Identities = 223/1046 (21%), Positives = 464/1046 (44%), Gaps = 104/1046 (9%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E      +EE+++V ++++  E +L  +    SQ + EK +LQ QL       QA+ E  
Sbjct: 844  EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL-------QAETELC 896

Query: 457  HSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLM 516
              +++ +  L+++   L++ C DLE  + + +   +   A       ++Q  EEQ +   
Sbjct: 897  AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 956

Query: 517  AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTL-------TSKLKASQAEIS 569
            +  + +Q   ++ +  +  L ++   L+ Q  ++  E+  L       T+ L   + +  
Sbjct: 957  SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK 1016

Query: 570  SLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQH 629
            SL  ++  ++  +   +E   R + +   ++  +    G    L  +   L  Q+ E + 
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM 1076

Query: 630  RSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQR--- 686
            +  K++  + A L  +E +   +  A  +I+E ++ + E LQ  LE     R + ++   
Sbjct: 1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE-LQEDLESERASRNKAEKQKR 1135

Query: 687  -MADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQT 745
             + +   +L+ +LE   L      Q+L + +++ ++++K+ TL +EA     Q  +  Q 
Sbjct: 1136 DLGEELEALKTELEDT-LDSTAAQQELRSKREQEVNILKK-TLEEEAKTHEAQIQEMRQK 1193

Query: 746  H---YDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLE-- 800
            H    +EL  +L + +   A+ E     L+NE+  L   ++    GK + +   +++E  
Sbjct: 1194 HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253

Query: 801  ---------EGTE---ETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQ 848
                     EG     E ++ + KL+ EL   +G +     +++ L K    ++ Q    
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313

Query: 849  KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV 908
            + +++   R   S       L    K+++ E    R++L +    K   E +++ LH +V
Sbjct: 1314 QELLQEENRQKLS-------LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366

Query: 909  AQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIE------- 961
            A +++ M D  G L++A++ + +++  L+ L    E+ VA  +  E  K +++       
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426

Query: 962  -ELQQEARKAIT-EQKQKM--RRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAK 1017
             +L  + + A   E+KQK   + L  + T + K  + + +A   A    ++ L  A A +
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE 1486

Query: 1018 EAAD--AELGQLRAQ---------GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQ 1066
            EA +  AEL +L  Q             D   ++HE  ++  A  Q V   KT LE EL+
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-ELE 1545

Query: 1067 EVIALTSQELEESREKVLELEDELQE-----SRGFRKKIKRLEESNKKLALELEHEKGKL 1121
            +       EL+ + +  L LE  LQ       R  + + ++ EE  K+L  ++   + +L
Sbjct: 1546 D-------ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598

Query: 1122 TGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASL 1181
                      R+  S+   A  K E DL  L   + +  + ++E  +Q++ L QA     
Sbjct: 1599 ED-------ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL-QAQMKDC 1650

Query: 1182 EKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQ 1241
             +E +   + +E++ A   +A  N +  K+   E+ ++++EL A E   ++ Q E D+L 
Sbjct: 1651 MRELDDTRASREEILA---QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707

Query: 1242 IREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQ 1301
                  S + A    E     A++  L+++L+E+     + N  ++    ++DQ      
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ------ 1761

Query: 1302 SLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKF-----MLQAKVSEL 1356
             +   L+L     +K  E  +Q L+    EL++  +++  T K K+      L+AK+++L
Sbjct: 1762 -INTDLNLERSHAQKN-ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819

Query: 1357 KNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            +  +    ++ Q     +RR   K +
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLK 1845



 Score =  168 bits (426), Expect = 3e-41
 Identities = 196/953 (20%), Positives = 423/953 (44%), Gaps = 99/953 (10%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E+   + +E + +  K++  LE     L  +++    + AELQAQ+A L  +L  + E  
Sbjct: 1026 EAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL 1085

Query: 457  HSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLM 516
             ++  R +  +++ +   +   +LE  +++LQ  LE++ AS   +    +   E+ + L 
Sbjct: 1086 QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALK 1145

Query: 517  AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
             ++ED          T+     Q      + Q+V + + TL  + K  +A+I   Q +RQ
Sbjct: 1146 TELED----------TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI---QEMRQ 1192

Query: 577  WYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKG 636
             + Q +    E   + +   A+++  + T       L  E   L Q   +++H+  K   
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK--- 1249

Query: 637  RIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQ 696
             + AQLQ ++    + E    ++ +  T ++ +L            +  ++    ++LE 
Sbjct: 1250 -VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308

Query: 697  QLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGE 756
            QL+  +  L + ++Q  +L  +   +  +    +E L+  E++   L+     L A++ +
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368

Query: 757  LQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEE---GTEETSETLEKL 813
            ++      ED++         LE A +  +  +++L+  ++R EE     ++  +T  +L
Sbjct: 1369 MK---KKMEDSVG-------CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 1418

Query: 814  REELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAY-----RRDATSKD----- 863
            ++EL      ++H +Q    L+K+ +K  +   ++K +   Y     R +A +++     
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478

Query: 864  -------QLISELKATRKRLDSELKELRQELMQVHGE--KRTAEAELSR--LHREVAQVR 912
                   +   E KA  +RL+ + +   ++LM    +  K   E E S+  L ++V +++
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538

Query: 913  QHMADLEGHLQSAQKERDEMETHLQSL--QFDKEQMVAVTEANEALKKQIEELQQEARKA 970
              + +LE  LQ+ +  +  +E +LQ++  QF+++      ++ E  K+ + ++++   + 
Sbjct: 1539 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598

Query: 971  ITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQ 1030
              E+KQ+     S   +A+K+++   K  E  +   ++   EA+       A++     +
Sbjct: 1599 EDERKQR-----SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653

Query: 1031 GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDEL 1090
                D + A  E I A   E +    S      +LQE +A   +   +++++  EL DE+
Sbjct: 1654 ---LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710

Query: 1091 QESRG----FRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE 1146
              S G      ++ +RLE    +L  ELE E+G              +  ++   L K  
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEEELEEEQG--------------NTELINDRLKKAN 1756

Query: 1147 ADLVQLNLQV---QAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAG 1203
              + Q+N  +   ++  Q+ E   +Q++   + L+  L++ +  V S K + +   +EA 
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS-KYKASITALEA- 1814

Query: 1204 HNRRHFKAASLE--LSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEA 1261
                  K A LE  L    KE QA    V++ + +  D+ ++     +   Q++ +  +A
Sbjct: 1815 ------KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA 1868

Query: 1262 RAQLQLLQKQLDEQLSKQPVGN-------QEMENLKWEVDQKEREIQSLKQQL 1307
              +L+ L++QL+E   +    N       +E+E+     D   RE+ SLK +L
Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score =  162 bits (411), Expect = 2e-39
 Identities = 199/916 (21%), Positives = 398/916 (43%), Gaps = 111/916 (12%)

Query: 584  LAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVS----------LSQQLTETQHRSMK 633
            LA++A  + Q ++  ++V Q   A    +LKL N            L Q   + +    K
Sbjct: 794  LARKAFAKRQQQLTAMKVLQRNCAA---YLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAK 850

Query: 634  EKGRIAAQLQGIEAD--MLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSA 691
            E+  +  + + + A+  + + E    Q+   K  ++E LQ   E      E   R+    
Sbjct: 851  EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKK 910

Query: 692  ASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQ 751
              LE+    ++  + + +++ + LQ E   + + +   +E L+  E +   LQ      +
Sbjct: 911  QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970

Query: 752  ARLGELQGEAASREDTICLLQNEKIILE-----------------AALQAAKSGKE---- 790
            A+L +L+ E    ED  C L  EK +LE                  +L   K+  E    
Sbjct: 971  AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030

Query: 791  ELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKV 850
            +L+   RR E+  +E  +T  KL  +    S Q+  LQ + A LK Q+ K +E+      
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090

Query: 851  MVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQ 910
             VE    +A  K+  + ++    + L+S++ EL+++L      +  AE +   L  E+  
Sbjct: 1091 RVE---EEAAQKNMALKKI----RELESQISELQEDLESERASRNKAEKQKRDLGEELEA 1143

Query: 911  VRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKA 970
            ++  + D      + Q+ R + E  +  L+   E+     EA      QI+E++Q+  +A
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA------QIQEMRQKHSQA 1197

Query: 971  I---TEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQL 1027
            +    EQ ++ +R+ ++L  A++ ++ +     N V +L +   ++   ++  +A+L +L
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257

Query: 1028 RAQGGSSDS-SLALHERIQALEAELQAV----SHSKTLLEKELQEVIALTSQELEESREK 1082
            + +    +     L +++  L+ EL  V    S S +   K  ++  AL SQ L++++E 
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ-LQDTQEL 1316

Query: 1083 VLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETAL 1142
               L++E ++      K+K++E+       +LE E                     E A 
Sbjct: 1317 ---LQEENRQKLSLSTKLKQVEDEKNSFREQLEEE---------------------EEAK 1352

Query: 1143 AKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAA--KV 1200
               E  +  L+ QV A +++K E+        + ++  L+K+ E ++   E+  AA  K+
Sbjct: 1353 HNLEKQIATLHAQV-ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL 1411

Query: 1201 EAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIRE----GKHSQEIAQFQA 1256
            E    R   +   L L ++  + Q+  +L +K Q + D L   E     K+++E  + +A
Sbjct: 1412 EKTKTRLQQELDDL-LVDLDHQRQSACNL-EKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469

Query: 1257 ELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRK 1316
            E  E   +   L + L+E + ++     E+E L  +   +  ++ S K  +  +  +  K
Sbjct: 1470 EAREKETKALSLARALEEAMEQK----AELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525

Query: 1317 ELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ----QNQQLKL 1372
                L+Q ++ +K++LE  +++L  T+  K  L+  +  +K   +  LQ    Q+++ K 
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1585

Query: 1373 DLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCL 1432
             L R   +   E + E    + A   +          LE  L+   A      KN +  +
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMAVAAR--------KKLEMDLKDLEAHIDSANKNRDEAI 1637

Query: 1433 QQLKQEMDSLQRQMEE 1448
            +QL++    LQ QM++
Sbjct: 1638 KQLRK----LQAQMKD 1649



 Score =  108 bits (270), Expect = 4e-23
 Identities = 175/907 (19%), Positives = 362/907 (39%), Gaps = 123/907 (13%)

Query: 105  RKSQGTSAEGSVRKEALQS----LRLSLPMQETQLCSTDSPLPLEK-EEQVRLQARKWLE 159
            RK +G S + S +   LQ+    L++ L  +E +L +  + +  E  ++ + L+  + LE
Sbjct: 1051 RKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE 1110

Query: 160  EQLKQYRVKRQQERSSQ--------------PATKTRLFSTLDP-----ELMLNPENLPR 200
             Q+ + +   + ER+S+               A KT L  TLD      EL    E    
Sbjct: 1111 SQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN 1170

Query: 201  ASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSG 260
                 + +E       +    +  S  +     + + +K  K       +T ++  G   
Sbjct: 1171 ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA 1230

Query: 261  GNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGD------SVSEVDGND 314
              V      KG  +  R    + + E+ +  +  +R+  T LA         +  V G  
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR-TELADKVTKLQVELDNVTGLL 1289

Query: 315  SDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADT-LGQFPSIKDVLQAAAAEHQ 373
            S S S SS  T+    + S+   TQ+     N Q++   T L Q    K+  +    E +
Sbjct: 1290 SQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 1349

Query: 374  DQGQEVNGEVRSRRDSICS-SVSLESSAA--ETQEEMLQVLKEKMRLEGQLEALSLEASQ 430
            +    +  ++ +    +      +E S    ET EE+      K +L+  LE LS    Q
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV------KRKLQKDLEGLS----Q 1399

Query: 431  ALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNM 490
              +EK     +L    T+LQ          Q  D L  ++D  +QS  +LE+       +
Sbjct: 1400 RHEEKVAAYDKLEKTKTRLQ----------QELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449

Query: 491  LEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQV 550
            L  +    A      + AEE+  R  A+  + +   LS    + +  +Q   L+   +Q 
Sbjct: 1450 LAEEKTISA------KYAEER-DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQF 1502

Query: 551  QLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLL 610
            + E   L S        +  L+  ++  +QQ+   +E + +L+     +Q  +  +  L 
Sbjct: 1503 RTEMEDLMSSKDDVGKSVHELEKSKRALEQQV---EEMKTQLEELEDELQATEDAKLRLE 1559

Query: 611  EHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDL 670
             +L+       + L     +S ++K ++  Q++ +EA++ D+         A+  +E DL
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL 1619

Query: 671  Q-----------------RRLEEFEGE-RERLQRMADSAASLEQQLEQVKLTLLQRDQQL 712
            +                 ++L + + + ++ ++ + D+ AS E+ L Q K    + +++L
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK----ENEKKL 1675

Query: 713  EALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDE--------------LQARLGELQ 758
            ++++ E + L ++L   + A +  +Q  D L                    L+AR+ +L+
Sbjct: 1676 KSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE 1735

Query: 759  GEAASREDTICLLQ-------------NEKIILEAA-LQAAKSGKEELDRGARRLEEGTE 804
             E    +    L+              N  + LE +  Q  ++ +++L+R  + L+   +
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795

Query: 805  ETSETLEK--------LREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYR 856
            E   T++         L  ++A    Q+++  +E  A  KQ+++ +++     + V+  R
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855

Query: 857  RDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMA 916
            R+A        +     K+L  +L+E  +E  + +  +R  + EL         + + ++
Sbjct: 1856 RNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVS 1915

Query: 917  DLEGHLQ 923
             L+  L+
Sbjct: 1916 SLKNKLR 1922



 Score = 44.3 bits (103), Expect = 9e-04
 Identities = 40/194 (20%), Positives = 87/194 (44%), Gaps = 7/194 (3%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRR---DSICSSVSLESSAAETQEEMLQVLKEKMRLEGQL 421
            L+    E Q   + +N  ++      D I + ++LE S A+  E   Q L E+   E ++
Sbjct: 1734 LEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQL-ERQNKELKV 1792

Query: 422  EALSLEASQALKEKAE---LQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCW 478
            +   +E +   K KA    L+A++A L  +L  + +   ++ ++      ++  +     
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852

Query: 479  DLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQ 538
            D  R     ++  +  +  L      L+ AEE+ QR  A    +QR +     T   + +
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNR 1912

Query: 539  QMTALQSQLQQVQL 552
            ++++L+++L++  L
Sbjct: 1913 EVSSLKNKLRRGDL 1926


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  197 bits (502), Expect = 5e-50
 Identities = 260/1146 (22%), Positives = 498/1146 (43%), Gaps = 170/1146 (14%)

Query: 360  SIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEG 419
            S +D L+   AE++    E + ++   +  I     L    A +  E     KE   L  
Sbjct: 228  SNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEP----KELEELRD 283

Query: 420  QLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWD 479
            + E+L++   + LK+  +L+ + + +  K+    E +     +    +S +  L+ +  +
Sbjct: 284  KNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNE 343

Query: 480  L-ERAMTDLQNMLEAK---NASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD 535
            L E      Q  LE +      L+++  D +  EE+ + L  K+  ++  +    +    
Sbjct: 344  LTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQ 403

Query: 536  LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE 595
             + ++     QL+ ++ E  TL +     QA +  L++ R          QEA+  L  E
Sbjct: 404  EKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG--------QQEAK--LLAE 453

Query: 596  MAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADML----- 650
              H +  +   + L+  L+    +LSQ   E +  S     R+ AQ+  + +++      
Sbjct: 454  RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513

Query: 651  ----DQEAAFM--QIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQV--- 701
                DQE A +  Q +E +  + + LQ++ +  +G R ++++++ S    EQQL++V   
Sbjct: 514  IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK 573

Query: 702  -------------------KLTLLQRD---QQLEALQQEHLD----LMKQLTLTQEALQS 735
                               + +L +RD   +QLEAL++E       L +QL +  EA  S
Sbjct: 574  QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633

Query: 736  REQSLDALQTHYDELQARLGELQG--EAASREDTICLLQNEKIILEAALQAAKSGKEELD 793
             + S+   Q    EL  ++ ELQ   E A +E      Q  ++ L+   +  K+ ++E  
Sbjct: 634  AQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE-- 691

Query: 794  RGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETA-ALKKQMQKIKEQFLQQKVMV 852
                R+ +  ++  E L+ L+E L +  G +E  ++  A AL++Q + I E   + + +V
Sbjct: 692  ----RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747

Query: 853  EAYRRDATSKDQLISELKATRKRLDSELKEL-----------RQELMQVHGEKRTAEAEL 901
            E ++R+       + E +A RK L++ L++L           R+EL +    + TAE+E 
Sbjct: 748  EQHKRERKE----LEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803

Query: 902  SRLHREVAQVRQHMADLEGH--------LQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
             +L +EVA  R+   D +           +     ++E E   Q LQ  KE++  +   +
Sbjct: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863

Query: 954  EA-LKKQIEELQQ------EARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGIL 1006
            E  + +Q  EL +       A + + E++ + ++L  DL++ Q++M    K     V  L
Sbjct: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE----VARL 919

Query: 1007 SRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ---ALEAELQAVSHSKTLLEK 1063
               +++A   +E A  EL +  A+ G         ++ +   + +A LQA       +E+
Sbjct: 920  ETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQA-------MER 972

Query: 1064 ELQEVIALTSQELEESREKVLELEDELQESRGFRKK-IKRLEESNKKLALELEHEKGKLT 1122
            E +++      ELE  R  ++E + + QE RG +++ + RL +   +   +L  EK    
Sbjct: 973  EAEQM----GNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK---- 1024

Query: 1123 GLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQAS-- 1180
                  AA  E    L+ AL ++  +   L   +   L  KE +D+++  L + L+A+  
Sbjct: 1025 ------AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKL-RGLEAAQI 1077

Query: 1181 --LEKEKEKVNSLKEQVAAAKVE--AGHNRRHFKAASLE-----LSEVKKELQAKEHLVQ 1231
              LE+ ++ V  LKEQ+A  + E  +G   +   A   E     L  ++ E+   E   Q
Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ 1137

Query: 1232 KLQAEADDLQ---------------------------IREGKHSQE-IAQFQAELAEARA 1263
            K Q +AD L+                            +E  HSQ  +A  Q ELA  R 
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197

Query: 1264 QLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQ 1323
            ++Q   K  DE  ++   G QE E     +   E E+  L +Q  + E++G  E + L++
Sbjct: 1198 KVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ--VLEKEG--ESKELKR 1253

Query: 1324 LLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRK 1383
            L+     + +  +E L + Q +     A+ +E  + ++  +Q  ++     R  +   R+
Sbjct: 1254 LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQ 1313

Query: 1384 EPKGEA 1389
            E   +A
Sbjct: 1314 ELTSQA 1319



 Score =  184 bits (466), Expect = 7e-46
 Identities = 317/1450 (21%), Positives = 604/1450 (41%), Gaps = 190/1450 (13%)

Query: 144  LEKEEQVRLQARKWLEE--QLKQYRVKRQQERSSQ-----PATKTRLFSTLDPELMLNPE 196
            LEKE    LQ +K LEE  ++ Q ++ + +E  SQ     P  K  +        +L  E
Sbjct: 362  LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGD-----VLQLE 416

Query: 197  NLPR-ASTLAMTKEYSFLRTSV---PRGPKVGS-LGLPAHPREKKTSKSSKIRSLADYRT 251
             L + A+TLA        R  +    RG +    L    H  E+K   SS I    D ++
Sbjct: 417  TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLI---TDLQS 473

Query: 252  EDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVD 311
              SN   +   +       G+  +  +  AS+ SE++    T  + ++  LAG    +  
Sbjct: 474  SISNLSQAKEELEQASQAHGA--RLTAQVASLTSELTTLNATIQQ-QDQELAG-LKQQAK 529

Query: 312  GNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAE 371
               +  +       + + G+  +             +++ +    +   +K+V +   A 
Sbjct: 530  EKQAQLAQTLQQQEQASQGLRHQV------------EQLSSSLKQKEQQLKEVAEKQEAT 577

Query: 372  HQDQGQEVNGEVRSRRDSICS-SVSLESSAAETQEE--MLQVLKEKMRLEGQL-EALSLE 427
             QD  Q++      R  S+     +L+   A  +E+   L++L++++++  +  ++    
Sbjct: 578  RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS 637

Query: 428  ASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTD- 486
             +QA +EKAEL  ++  L   ++   +  H +Q +   L  ++ + +Q   + ER   + 
Sbjct: 638  VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK 697

Query: 487  --LQNMLEAKNASLASSNNDLQV-------AEEQYQRLMAKVEDMQRSMLSKD----NTV 533
              LQ  L+A   SL  +   L+        A E+ QR +++++   RS++ +       +
Sbjct: 698  DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKEL 757

Query: 534  HDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA-RVRL 592
             + R     L+++LQQ+       T  L+   AE  + Q   +   +QL     A R R 
Sbjct: 758  EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY 817

Query: 593  Q-GEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLD 651
            +  +    Q G M Q  L+  LK E     Q+L E + +    +     Q+   + ++ +
Sbjct: 818  EDSQQEEAQYGAMFQEQLMT-LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAE 876

Query: 652  QEA----AFMQIQEAKTMVEE------DLQRRLEEFEGERERLQRMADSAASLEQ--QLE 699
              A    A  Q+QE +   ++       LQ ++     E  RL+ +   A   ++    E
Sbjct: 877  LHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRE 936

Query: 700  QVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQG 759
             VK      D+Q E L+++     +Q   TQ ALQ+ E+  + +    + L+A L E QG
Sbjct: 937  LVKEPARAGDRQPEWLEEQQ---GRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG 993

Query: 760  -----------------------------EAASREDTICLLQN-------EKIILEAALQ 783
                                         E A+R +    LQN       E   L+ AL 
Sbjct: 994  QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053

Query: 784  AAKSGKEELDRGARRLE-------EGTEETSETLEKLREELAIK--------------SG 822
             A + KE  D+   +L        +  EE  +T+++L+E+LA K              +G
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113

Query: 823  QVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKE 882
            + E    +  AL+ ++ K+++Q  +Q+   ++  R   ++    +E  +  + L  +L+E
Sbjct: 1114 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1173

Query: 883  LRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFD 942
              QEL        +A+ EL+    +V    +   + +  +   ++E +   + + SL+ +
Sbjct: 1174 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 1233

Query: 943  ------------------KEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSD 984
                              K  ++A +E ++ L++++  LQ E         ++   L  +
Sbjct: 1234 VSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREE 1293

Query: 985  LTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ-LRA------QGGSSDSS 1037
            + S ++E + +  A EN        L++ L ++     ELGQ L+A      Q   + S+
Sbjct: 1294 VQSLREEAEKQRVASEN--------LRQELTSQAERAEELGQELKAWQEKFFQKEQALST 1345

Query: 1038 LAL-HERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEES-------REKVLELEDE 1089
            L L H   QAL +EL    H    L+ E         +ELE+S       R ++L  + E
Sbjct: 1346 LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRE 1405

Query: 1090 LQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSIL-ETALAKREAD 1148
            L E    R+K+   E + ++L  E      +L+ L +++  L E N  L E A   R+  
Sbjct: 1406 LGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFL 1465

Query: 1149 LVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRH 1208
             V+L+   +  +Q         +  +  +Q   +    ++  +  +   AKV+    R+ 
Sbjct: 1466 EVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQR 1525

Query: 1209 FK------AASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEAR 1262
            F+       A +E  EV +  Q K+  V++L  +  D         Q++   QA+  E++
Sbjct: 1526 FQEERQKLTAQVEQLEVFQREQTKQ--VEELSKKLADSDQASKVQQQKLKAVQAQGGESQ 1583

Query: 1263 AQLQLLQKQLDE---QLSKQPVGNQ----EMENLKWEVDQKEREIQSLKQQLDLTEQQGR 1315
             + Q LQ QL+E   QLS++    +    +ME  K   D K+++ Q L++QL   EQ  +
Sbjct: 1584 QEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQL-Q 1642

Query: 1316 KELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL-KLDL 1374
            KE + L+   + +  EL+ A       ++    L A+V  L+  +    QQ + L K  +
Sbjct: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQV 1702

Query: 1375 RRGAAKTRK-EPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQ 1433
               A K+R+ + K +   S  +  +   +   P S+  +L R  P  +  P +  +   Q
Sbjct: 1703 ATDALKSREPQAKPQLDLSIDSLDLSCEE-GTPLSITSKLPRTQPDGTSVPGEPASPISQ 1761

Query: 1434 QLKQEMDSLQ 1443
            +L  +++SL+
Sbjct: 1762 RLPPKVESLE 1771



 Score =  149 bits (375), Expect = 3e-35
 Identities = 243/1097 (22%), Positives = 449/1097 (40%), Gaps = 147/1097 (13%)

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSS----QQRQDSLSSEVDTLKQSCWDLE 481
            L ++Q + E +EL+  LA ++  L      S  S    +Q +  + +E+  + +   D E
Sbjct: 81   LVSAQKVLEGSELE--LAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHE 138

Query: 482  RAMT---DLQNMLE-AKNASLASSN--NDLQVAEEQYQRLMAKVEDMQRSMLSKDNT--- 532
              +    DL+N L+ A   S  SS    +L     Q +R +  +E  + +  S  N    
Sbjct: 139  DGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLS 198

Query: 533  ------VHDLRQ----QMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQL 582
                  + D+ Q    QM  L+ QL   +  R  L  +L  ++  ++   +       Q+
Sbjct: 199  GSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDA-------QI 251

Query: 583  ALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQL 642
            A+ Q+   RL   +   Q     +   LE L+ +N SL+ +L ET             Q 
Sbjct: 252  AMMQQRIDRL-ALLNEKQAASPLEPKELEELRDKNESLTMRLHET-----------LKQC 299

Query: 643  QGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVK 702
            Q ++ +    +    Q+ E       DL  +L EF      LQ++ D+   L ++  +  
Sbjct: 300  QDLKTEKSQMDRKINQLSEENG----DLSFKLREFASH---LQQLQDALNELTEEHSKAT 352

Query: 703  LTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAA 762
               L++  QLE      L   K L    E LQ +   L  L+ H  +LQ    + +GE  
Sbjct: 353  QEWLEKQAQLEKELSAALQDKKCLEEKNEILQGK---LSQLEEHLSQLQDNPPQEKGEVL 409

Query: 763  SREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEK--LREELAIK 820
                   +LQ E +  EAA  AA + + +        E G +E     E+    EE    
Sbjct: 410  GD-----VLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQL 464

Query: 821  SGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSEL 880
            S  +  LQ   + L +  +++++        + A     TS+   ++ L AT ++ D EL
Sbjct: 465  SSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE---LTTLNATIQQQDQEL 521

Query: 881  KELRQELMQVHGEK----RTAEAELSRLHREVAQVRQHMADLEGHLQS-AQKERDEMETH 935
              L+Q+  +   +     +  E     L  +V Q+   +   E  L+  A+K+    + H
Sbjct: 522  AGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH 581

Query: 936  LQSLQFDKEQMVAVTEANEALKKQIEELQQE--ARKAITEQKQKMRRLGSDLTSAQKEMK 993
             Q L    E+  A     +A  KQ+E L++E  A+  I +Q+ ++     D         
Sbjct: 582  AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA 641

Query: 994  TKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQA 1053
             + KA       LSR+++E  A  E A  E  Q  AQ   ++  L L    Q    E + 
Sbjct: 642  QREKAE------LSRKVEELQACVETARQE--QHEAQAQVAELELQLRSE-QQKATEKER 692

Query: 1054 VSHSKTLLEKELQ---EVIALTSQELEESREKVLE-LEDELQESRGFRKKIKRLEESNKK 1109
            V+  K  L+++LQ   E + +T   LEE + +  + LE++ +     + + + L E +K+
Sbjct: 693  VAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 752

Query: 1110 LALELEHE----KGKLTGLGQSNAALREHNSILETALAKR-------EADLVQLNLQVQA 1158
               ELE E    KG    L Q   A +    +L   LA+        E++  QL  +V A
Sbjct: 753  ERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAA 812

Query: 1159 VLQRKEEEDRQ-------MKHLVQALQASLEKEKEKVNSLKEQVAA----AKVEAGHNRR 1207
              +R E+  ++        +  +  L+   EK ++++   KE+VA     ++++    + 
Sbjct: 813  WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQN 872

Query: 1208 HFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQL 1267
                    L+   +++Q KE   QKL  +   LQ +    S+E+A+ +  + +A  Q + 
Sbjct: 873  ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQET 932

Query: 1268 LQKQLDEQLSK----QPVGNQEMENLKW-----EVDQKEREIQSLKQQLD-----LTEQQ 1313
              ++L ++ ++    QP   +E +  ++      +   ERE + +  +L+     L E Q
Sbjct: 933  ASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQ 992

Query: 1314 GRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLD 1373
            G+++ E  QQ     + E+    ++    Q D  + +A  +EL+  ++  L + +     
Sbjct: 993  GQQQEERGQQ-----EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047

Query: 1374 LRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQ 1433
            L+   A    E +G+                      ++ L     +    +K L    Q
Sbjct: 1048 LQEALAHALTEKEGK----------------------DQELAKLRGLEAAQIKELEELRQ 1085

Query: 1434 QLKQEMDSLQRQMEEHA 1450
             +KQ  + L ++ +EHA
Sbjct: 1086 TVKQLKEQLAKKEKEHA 1102



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 123/552 (22%), Positives = 217/552 (39%), Gaps = 95/552 (17%)

Query: 1006 LSRRLQEALAAKEAADAELGQLRAQGGSSDSSLAL-HERIQALEAELQAVSHSKTLLEKE 1064
            L ++L +  + ++  + EL + R      D+ +A+  +RI  L A L     +  L  KE
Sbjct: 219  LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRL-ALLNEKQAASPLEPKE 277

Query: 1065 LQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALEL---------- 1114
            L+E+            E + + +D   E     +KI +L E N  L+ +L          
Sbjct: 278  LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQL 337

Query: 1115 ---------EHEKG-------------KLTGLGQSNAALREHNSILETALAKREADLVQL 1152
                     EH K              +L+   Q    L E N IL+  L++ E  L QL
Sbjct: 338  QDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQL 397

Query: 1153 -------------------------------NLQVQAVLQRKEEEDRQMKHLVQALQASL 1181
                                           N Q+QA ++  E E  Q +  + A +   
Sbjct: 398  QDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF 457

Query: 1182 EKEKEKVNSL--------------KEQVAAAKVEAGHNRRHFKAASL--ELSEVKKELQA 1225
            E+EK++++SL              KE++  A  +A   R   + ASL  EL+ +   +Q 
Sbjct: 458  EEEKQQLSSLITDLQSSISNLSQAKEELEQAS-QAHGARLTAQVASLTSELTTLNATIQQ 516

Query: 1226 KEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQL----SKQPV 1281
            ++  +  L+ +A + Q +  +  Q+  Q    L     QL    KQ ++QL     KQ  
Sbjct: 517  QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576

Query: 1282 GNQE-MENLKWEVDQKE---REIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQE 1337
              Q+  + L    +++E   RE  +  +QL+  E++   +LE LQQ LQ      + AQ 
Sbjct: 577  TRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636

Query: 1338 DLSMTQKDKFMLQAKVSELKNNMKTLLQ-----QNQQLKLDLRRGAAKTRKEPKGEASSS 1392
             ++  Q++K  L  KV EL+  ++T  Q     Q Q  +L+L+  + + +   K   +  
Sbjct: 637  SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE 696

Query: 1393 NPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALT 1452
                  ++        + +  L      + + L+    C+ +LK E  SL  Q +     
Sbjct: 697  KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKE 756

Query: 1453 VHESLSSWTPLE 1464
            + E  +    LE
Sbjct: 757  LEEERAGRKGLE 768


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  187 bits (476), Expect = 5e-47
 Identities = 211/1037 (20%), Positives = 456/1037 (43%), Gaps = 84/1037 (8%)

Query: 370  AEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEML-------QVLKEKMRLEGQLE 422
            A  QD  ++++ E  +R+      V+ E+   + +EE+L       + +KEK  +E ++ 
Sbjct: 950  AHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIA 1009

Query: 423  ALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLER 482
                E S  L E+ E    LA +  K +  +       ++++    E++  K+    L+ 
Sbjct: 1010 ----ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK---LDG 1062

Query: 483  AMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTA 542
              TDLQ+ +    A +      L   EE+ Q  +A+ +D      +    V +L+ Q+  
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122

Query: 543  LQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVG 602
            LQ   +  +  R     + +    E+ +L++  +      A  QE R + + E+A ++  
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182

Query: 603  ----QMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQ 658
                       ++ ++  + +  ++L+E   ++ + K  +    QG+E D  +       
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242

Query: 659  IQEAKTMVE---EDLQRRLEEF-----EGERERLQRMADSAASLEQQLEQVKLTLLQRDQ 710
            +Q+ K   E   + L  +++E      EG+R R++ +A+ A+ L+ +L+ V   L + ++
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE-LAEKASKLQNELDNVSTLLEEAEK 1301

Query: 711  QLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICL 770
            +     ++   L  QL  TQE LQ   +    L +   +L+     LQ +    E+    
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
            L+ + + L++ L   K   ++       LEE  ++  +  E L + L  K+   + L++ 
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
               L++++  +      Q+ +     +     DQL++E K+   R   E      E    
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR-- 1479

Query: 891  HGEKRTAEAELSRLHREVAQVRQHM----ADLEGHLQSAQKERDEMETHLQSLQFDKEQM 946
              EK T    L+R   E  + ++        L   ++     +D++  ++  L+  K   
Sbjct: 1480 --EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR-- 1535

Query: 947  VAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ--KEMKTKHKAYENAVG 1004
             A+ +  E ++ Q+EEL+ E +   TE  +    +      AQ  ++++T+ +  E    
Sbjct: 1536 -ALEQQVEEMRTQLEELEDELQ--ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR 1592

Query: 1005 ILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHE-RIQALEAELQAVSHSKTLLEK 1063
            +L ++++E        +AEL   R Q   + +S    E  ++ LEA+++A + ++  + K
Sbjct: 1593 LLIKQVRE-------LEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645

Query: 1064 ELQEVIALT---SQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK 1120
            +L+++ A      +ELEE+R    E+  + +ES    KK+K LE    +L  EL   +  
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKES---EKKLKSLEAEILQLQEELASSERA 1702

Query: 1121 LTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQAS 1180
                 Q    L +      T  A  ++ L+    +++A + + EEE  + +  ++ L   
Sbjct: 1703 RRHAEQERDELADE----ITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758

Query: 1181 LEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDL 1240
              K   +V++L  ++AA +  A  +      A  +L    KEL+AK   +Q+L+      
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDN----ARQQLERQNKELKAK---LQELEGAVK-- 1809

Query: 1241 QIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREI 1300
                       ++F+A ++   A++  L++QL+++  ++   N+ +   + ++ +   ++
Sbjct: 1810 -----------SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858

Query: 1301 QSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNM 1360
            +  ++  D    Q ++++E     ++ +K +LE A+E+ +     +  LQ ++ +     
Sbjct: 1859 EDERRHAD----QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914

Query: 1361 KTLLQQNQQLKLDLRRG 1377
            + L ++   LK  LRRG
Sbjct: 1915 EGLSREVSTLKNRLRRG 1931



 Score =  184 bits (466), Expect = 7e-46
 Identities = 231/1100 (21%), Positives = 463/1100 (42%), Gaps = 158/1100 (14%)

Query: 358  FPSIKDVLQAAAAEHQDQGQEVNG-EVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMR 416
            F  +K +LQ    E + Q ++    +V+ ++  +      E    E + +  Q+L+EK  
Sbjct: 838  FTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKV------EGELEEMERKHQQLLEEKNI 891

Query: 417  LEGQLEA---LSLEA----SQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSE 469
            L  QL+A   L  EA    ++   +K EL+  L  L ++++ + E +   Q  +  + + 
Sbjct: 892  LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951

Query: 470  VDTLKQSCWDLERAMTDLQ-----------------NMLEAKNASLASSNNDLQ------ 506
            +  L++   + E A   LQ                  +LE +N+        ++      
Sbjct: 952  IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011

Query: 507  ----VAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLK 562
                  EE+  + +AK+ + Q  M+S      DL +++   +   Q+++  +  L  +  
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMIS------DLEERLKKEEKTRQELEKAKRKLDGETT 1065

Query: 563  ASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQ 622
              Q +I+ LQ+     + QLA  +E    LQG +A      + +   L+ ++     L  
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEE---ELQGALARGDDETLHKNNALKVVR----ELQA 1118

Query: 623  QLTETQ----------HRSMKEKGRIAAQLQGIEA---DMLDQEAAFMQIQEAKTMVEED 669
            Q+ E Q          +++ K+K  ++ +L+ ++    D LD  AA  +++  +     +
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178

Query: 670  LQRRLEEFEGERE-----RLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMK 724
            L++ LEE     E       QR A +   L +QLEQ K      ++  + L+ ++ +L  
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238

Query: 725  QLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784
            ++ + Q+     E     L     EL A++ E         +    LQNE   +   L+ 
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298

Query: 785  AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKE- 843
            A+    +  + A  LE   ++T E L++   +    S ++  L++E  +L++Q ++ +E 
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358

Query: 844  -QFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELS 902
             + L+++V+             L S+L  T+K++D +L           G   + E    
Sbjct: 1359 RKNLEKQVLA------------LQSQLADTKKKVDDDL-----------GTIESLEEAKK 1395

Query: 903  RLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEE 962
            +L ++   + Q + +        +K ++ ++  L  L  D +    V    E  +K+ ++
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 963  LQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADA 1022
            L       + E+K    R   +   A+ E + K    E     L+R L+EAL AKE  + 
Sbjct: 1456 L-------LAEEKSISARYAEERDRAEAEAREK----ETKALSLARALEEALEAKEEFER 1504

Query: 1023 ELGQLRA-----QGGSSDSSLALHERIQALEAELQAVSHSKTLLEK---ELQEV------ 1068
            +  QLRA          D    +HE  ++  A  Q V   +T LE+   ELQ        
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564

Query: 1069 IALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN 1128
            + +  Q ++   E+ L+  DE  E +  R  IK++ E    L  ELE E           
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKK-RLLIKQVRE----LEAELEDE----------- 1608

Query: 1129 AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
               R+  ++   +  K E DL  L  Q++A  + ++E  +Q++ L QA     ++E E+ 
Sbjct: 1609 ---RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL-QAQMKDYQRELEEA 1664

Query: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248
             + ++++ A   E   + +  K+   E+ ++++EL + E   +  + E D+L       +
Sbjct: 1665 RASRDEIFAQSKE---SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721

Query: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD 1308
               +    E     A++  L+++L+E+ S   + N        +VD    E+ +      
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA------ 1775

Query: 1309 LTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKF-----MLQAKVSELKNNMKTL 1363
              E+   ++ +  +Q L+    EL+   ++L    K KF      L+AK+ +L+  ++  
Sbjct: 1776 --ERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833

Query: 1364 LQQNQQLKLDLRRGAAKTRK 1383
             ++       +RR   K ++
Sbjct: 1834 AKERAAANKLVRRTEKKLKE 1853



 Score =  153 bits (386), Expect = 1e-36
 Identities = 199/918 (21%), Positives = 399/918 (43%), Gaps = 100/918 (10%)

Query: 606  QAGLLEHL------KLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQI 659
            +AG+L HL      K+ ++ +  Q     + + K   +   QL  ++  +    AA++++
Sbjct: 771  RAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKV-LQRNCAAYLKL 829

Query: 660  QEAK-----TMVEEDLQ--RRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQL 712
            +  +     T V+  LQ  R+ EE + + E L ++ +    +E +LE+++    ++ QQL
Sbjct: 830  RHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEME----RKHQQL 885

Query: 713  EALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQ 772
              L+++++ L +QL    E     E+    L     EL+  L +L+      E+   +LQ
Sbjct: 886  --LEEKNI-LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ 942

Query: 773  NEKIILEAALQAAKSGKEELDRGARRLEEGTEETSET-LEKLREELAIKSGQVEHLQQET 831
            NEK  ++A +Q  +   +E + GAR+  +  + T+E  ++K+ EE+ +   Q     +E 
Sbjct: 943  NEKKKMQAHIQDLEEQLDE-EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001

Query: 832  AALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVH 891
              ++ ++ +   Q  +++   +   +    ++ +IS+L+   K+ +   +EL +   ++ 
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061

Query: 892  GEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHL-QSLQFDKEQMVAVT 950
            GE    + +++ L  ++ +++  +A  E  LQ A    D+   H   +L+  +E    + 
Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121

Query: 951  EANE----------ALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYE 1000
            E  E            +KQ  +L +E     TE +  +     D T+AQ+E++TK    E
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL-----DTTAAQQELRTKR---E 1173

Query: 1001 NAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTL 1060
              V  L + L+E     EA   ++ Q  A      S     E+ +  +A L+        
Sbjct: 1174 QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL--EQAKRFKANLEKNKQGLET 1231

Query: 1061 LEKELQEVIALTSQELEESREKVLELEDELQE-----SRGFRKKIKRLEESNKKLALELE 1115
              KEL   + +  Q   ES  K  +L+ ++QE     S G R +++ L E   KL  EL+
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE-LAEKASKLQNELD 1290

Query: 1116 H-----EKGKLTGLGQSNAALREHNSILETALAKREADLVQLNL---------QVQAVLQ 1161
            +     E+ +  G+  +  A    + + +T    +E    +LNL         +  ++ +
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350

Query: 1162 RKEEEDRQMKHL---VQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSE 1218
            ++EEE+   K+L   V ALQ+ L   K+KV+     + + +       +  +A S  L E
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410

Query: 1219 VKKELQAKEHLVQKLQAEADDLQIREGKHSQEIA--------QFQAELAEA--------- 1261
                    E    +LQ E DDL + +  H +++A        +F   LAE          
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTV-DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE 1469

Query: 1262 ---RAQLQLLQKQ-----LDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQ 1313
               RA+ +  +K+     L   L +     +E E    ++     ++ S K  +     +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1529

Query: 1314 GRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLD 1373
              K    L+Q ++ ++++LE  +++L  T+  K  L+  +  +K   +  LQ   +   +
Sbjct: 1530 LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEE 1589

Query: 1374 LRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSK---EPLKNLNS 1430
             +R   K  +E + E         + +         L++L     A +K   E +K    
Sbjct: 1590 KKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ--- 1646

Query: 1431 CLQQLKQEMDSLQRQMEE 1448
             L++L+ +M   QR++EE
Sbjct: 1647 -LRKLQAQMKDYQRELEE 1663



 Score =  149 bits (377), Expect = 2e-35
 Identities = 190/900 (21%), Positives = 375/900 (41%), Gaps = 121/900 (13%)

Query: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ 420
            ++D L   AA+          E+R++R+   + +  ++   ET+    Q+   + R    
Sbjct: 1155 LEDTLDTTAAQQ---------ELRTKREQEVAELK-KALEEETKNHEAQIQDMRQRHATA 1204

Query: 421  LEALSLEASQALKEKAELQAQLAALST---------KLQAQVECSHSSQQRQDSLSSEVD 471
            LE LS +  QA + KA L+     L T         K+  QV+    S+ ++  L ++V 
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE--SEHKRKKLDAQVQ 1262

Query: 472  TLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDN 531
             L     + +R   +L          L + +  L+ AE++  +       ++  +     
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322

Query: 532  TVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVR 591
             + +  +Q   L S+++Q++ E+ +L  + +  +    +L+      Q QLA   + + +
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA---DTKKK 1379

Query: 592  LQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTE---TQHRSMKEKGRIAAQLQGIEAD 648
            +  ++  I+  +  +  LL+  +    +LSQ+L E      +  K K R+  +L  +  D
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAE----ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD 1435

Query: 649  MLDQEAAFMQIQEAKTMVEEDLQRRLE---EFEGERERLQRMA----DSAASLEQQLEQV 701
            +  Q      +++ +   ++ L         +  ER+R +  A      A SL + LE+ 
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495

Query: 702  KLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEA 761
                 + ++Q + L+ +  DLM       + +   E+S  AL+   +E++ +L EL+ E 
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555

Query: 762  ASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKS 821
             + ED        K+ LE  +QA K+   + +R  +  +E  EE    L K   EL  + 
Sbjct: 1556 QATEDA-------KLRLEVNMQAMKA---QFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605

Query: 822  GQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELK 881
             + E  Q+  A   K+  +I  + L+ ++      RD   K   + +L+A  K    EL+
Sbjct: 1606 -EDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ--LRKLQAQMKDYQRELE 1662

Query: 882  ELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQF 941
            E R    ++  + + +E +L  L  E+ Q+++ +A  E   + A++ERDE+   + +   
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSAS 1722

Query: 942  DKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYEN 1001
             K    A+ +    L+ +I +L++E    + E++  M                       
Sbjct: 1723 GKS---ALLDEKRRLEARIAQLEEE----LEEEQSNME---------------------- 1753

Query: 1002 AVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSS-LALHERIQALEAELQAVSHSKTL 1060
               +L+ R ++     +  +AEL   R+    SD++   L  + + L+A+LQ +  +   
Sbjct: 1754 ---LLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810

Query: 1061 LEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK 1120
              K     +     +LEE      +LE E +E     K ++R E+  K++ +++E E   
Sbjct: 1811 KFKATISALEAKIGQLEE------QLEQEAKERAAANKLVRRTEKKLKEIFMQVEDE--- 1861

Query: 1121 LTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQAS 1180
                       R H    +  + K  A + QL  Q    L+  EEE  +     + LQ  
Sbjct: 1862 -----------RRHADQYKEQMEKANARMKQLKRQ----LEEAEEEATRANASRRKLQRE 1906

Query: 1181 LEKEKEKVNSLKEQVAAAK-------------VEAGHNRRHFKAASLELSEVKKELQAKE 1227
            L+   E    L  +V+  K               +G  + H + ASLELS+   E +  +
Sbjct: 1907 LDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSD 1966


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  186 bits (471), Expect = 2e-46
 Identities = 226/1088 (20%), Positives = 471/1088 (43%), Gaps = 134/1088 (12%)

Query: 358  FPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL 417
            F  +K +LQ    E + Q +E   +    R         E+   E +++  Q+ +EK  L
Sbjct: 838  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ-----KAENELKELEQKHSQLTEEKNLL 892

Query: 418  EGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSC 477
            + QL+A     ++   E  E++ +LAA   +L+   E  H  + R +        L+   
Sbjct: 893  QEQLQA----ETELYAEAEEMRVRLAAKKQELE---EILHEMEARLEEEEDRGQQLQAER 945

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAK--VEDMQRSMLSKDNTVHD 535
              + + M DL+  LE + A+      +   AE + ++L  +  V D Q + LSK+  +  
Sbjct: 946  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL-- 1003

Query: 536  LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE 595
            L ++++ L + L + + +   LT      ++ IS L+   +  ++     ++ + +L+G+
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063

Query: 596  MA--HIQVGQMTQAGLLEHLKLENVSLSQQLTET-------------------------- 627
             +  H Q+  + QA + E LK++     ++L                             
Sbjct: 1064 ASDFHEQIADL-QAQIAE-LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121

Query: 628  ------------QHRSMKEKGRIAAQLQGIEA---DMLDQEAAFMQIQEAK----TMVEE 668
                        ++++ K+K  +  +L+ ++    D LD  A   +++  +    T++++
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 669  DLQRRLEEFEGE-RERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLT 727
             L       E + +E  Q+ A +   L +QLEQ K      D+  + L++E+ DL  +L 
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241

Query: 728  LTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
            +  +A Q  E     L+    ELQ++  + +   A   D +  LQNE   +   L  A+ 
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301

Query: 788  GKEELDRGARRLEEGTEETSETL-EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFL 846
               +L +    L    ++T E L E+ R++L + S ++  L++E  +L+ Q+ +  E   
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNV-STKLRQLEEERNSLQDQLDEEME--- 1357

Query: 847  QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHR 906
                          +K  L   +      L+ +L + +++L          E    R  +
Sbjct: 1358 --------------AKQNLERHIST----LNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399

Query: 907  EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            E+  + Q   +        +K ++ ++  L  L  D +           L   +E+ Q++
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN-------QRQLVSNLEKKQRK 1452

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
              + + E+K    +   +   A+ E + K    E     L+R L+EAL AKE  +     
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREK----ETKALSLARALEEALEAKEELERTNKM 1508

Query: 1027 LRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE 1085
            L+A+     SS   + + +  LE   +A+      ++ +L+E+      EL+ + +  L 
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL----EDELQATEDAKLR 1564

Query: 1086 LEDELQESRG-FRKKIKRLEESNKKLALELEHEKGKL-TGLGQSNAALREHNSILETALA 1143
            LE  +Q  +G F + ++  +E N++   +L+ +  +  T L       R+  ++   A  
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE----RKQRALAAAAKK 1620

Query: 1144 KREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAG 1203
            K E DL  L LQ  + ++ +EE  +Q++ L QA     ++E E   + ++++ A    A 
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKL-QAQMKDFQRELEDARASRDEIFAT---AK 1676

Query: 1204 HNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQF---QAELAE 1260
             N +  K+   +L +++++L A E   ++   E ++L       ++E+A     +  L +
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-------AEELASSLSGRNALQD 1729

Query: 1261 ARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG 1320
             + +L+    QL+E+L ++  GN  ME +   V +  ++ + L  +L  TE+   ++ E 
Sbjct: 1730 EKRRLEARIAQLEEELEEEQ-GN--MEAMSDRVRKATQQAEQLSNEL-ATERSTAQKNES 1785

Query: 1321 LQQLLQNVKSELEMAQEDLSMTQKDKF-----MLQAKVSELKNNMKTLLQQNQQLKLDLR 1375
             +Q L+    EL     ++    K KF      L+AK+++L+  ++   ++ Q     L+
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1845

Query: 1376 RGAAKTRK 1383
            +   K ++
Sbjct: 1846 QKDKKLKE 1853



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/772 (21%), Positives = 308/772 (39%), Gaps = 111/772 (14%)

Query: 725  QLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784
            Q+T  +E +Q++E  L   +    + +  L EL+ + +        L  EK +L+  LQA
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ-------LTEEKNLLQEQLQA 898

Query: 785  AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
                  E +    RL    +E  E L ++   L  +  + + LQ E   + +QM  ++EQ
Sbjct: 899  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 845  F-----LQQKVMVEAYRRDATSK---------DQLISELKATRKRLDSELKELRQELMQV 890
                   +QK+ +E    +A  K         D   ++L   RK L+  + +L   L + 
Sbjct: 959  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018

Query: 891  HGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVT 950
              EK     +L   H  +      +++LE  L+  +K R E+E   + L+ D        
Sbjct: 1019 E-EKAKNLTKLKNKHESM------ISELEVRLKKEEKSRQELEKLKRKLEGDASDF---H 1068

Query: 951  EANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRL 1010
            E    L+ QI EL+ +  K   E +  + RL  ++      +K K +  E  +  L   L
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1127

Query: 1011 QEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSK-TLLEKELQEVI 1069
                AA+  A+ +   L  +  +  + L       A + EL+A    + T+L+K L E  
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187

Query: 1070 ALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN 1128
                 +++E R+K  +  +EL E    F++    L+++ + L  E     G+L  LGQ+ 
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247

Query: 1129 AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
              +      LE               QVQ +  +  + +R    L   +   L+ E E V
Sbjct: 1248 QEVEHKKKKLEA--------------QVQELQSKCSDGERARAELNDKVH-KLQNEVESV 1292

Query: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248
              +  +     ++     +   + S +L + ++ LQ  E   QKL       Q+ E ++S
Sbjct: 1293 TGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQ--EETRQKLNVSTKLRQLEEERNS 1347

Query: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD 1308
                               LQ QLDE++  +    + +  L  ++   ++++Q     ++
Sbjct: 1348 -------------------LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388

Query: 1309 LTEQ---QGRKELEGLQQL----------LQNVKSELEMAQEDLSMTQKDKFMLQAKVSE 1355
              E+   + +KE+E L Q           L+  K+ L+   +DL +   ++  L + + +
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448

Query: 1356 LKNNMKTLLQQNQQLK---LDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEE 1412
             +     LL + + +     D R  A    +E + +A S               A  LEE
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL--------------ARALEE 1494

Query: 1413 LLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLE 1464
             L      +KE L+  N   + LK EM+ L    ++    VHE   S   LE
Sbjct: 1495 ALE-----AKEELERTN---KMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538



 Score =  115 bits (288), Expect = 3e-25
 Identities = 195/956 (20%), Positives = 388/956 (40%), Gaps = 121/956 (12%)

Query: 100  FHDNLRKSQGTSAEGSVR-KEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWL 158
            FH+ +   Q   AE  ++  +  + L+ +L   + ++   ++ L   +E +  +     L
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD---L 1123

Query: 159  EEQLKQYRVKRQQERSSQ-------PATKTRLFSTLDP-----ELMLNPENLPRASTLAM 206
            +E L   R  R +    +        A KT L  TLD      EL    E        A+
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 207  TKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGNVPAP 266
             +E       V    +  +  +     + +  K +K     + +T +    +  G +   
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 267  DSTKGSLKQNRSSAASVVSEISLSPDTDDRL-----ENTSLAGDSVSEVDGNDSDSSSYS 321
               K  ++  +    + V E+       +R      +      + V  V G  +++   +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 322  SASTRGTYGILSKTVGTQDTPYMVNGQEIPADT-LGQFPSIKDVLQAAAAEHQDQGQEVN 380
                +    + S+   TQ+       Q++   T L Q    ++ LQ    E  +  Q + 
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363

Query: 381  GEVRSRRDSICSSVSLESSAAETQEEMLQ----VLKEKMRLEGQLEALSLEASQALKEKA 436
              + +    +  S       A T E + +      KE   L  Q E  +    +  K K 
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423

Query: 437  ELQAQLAALSTKLQAQVECSHSSQQRQ---DSLSSEVDTLKQSCWD-LERAMTDLQNMLE 492
             LQ +L  L   L  Q +   + +++Q   D L +E   +     D  +RA  + +   E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-E 1482

Query: 493  AKNASLASSNNDLQVAEEQYQR----LMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQ 548
             K  SLA +  +   A+E+ +R    L A++ED+  S       VH+L +   AL++Q++
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 549  QVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAG 608
            +++ +   L  +L+A++                     +A++RL+  M  ++ GQ  +  
Sbjct: 1543 EMKTQLEELEDELQATE---------------------DAKLRLEVNMQALK-GQFERD- 1579

Query: 609  LLEHLKLENVSLSQQLTETQHR-------SMKEKGRIAAQLQGIEADMLD---------- 651
             L+    +N    +QL    H          K++   AA  + +E D+ D          
Sbjct: 1580 -LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638

Query: 652  -QEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADS----AASLEQQLEQVKLTLL 706
             +E A  Q+++ +  ++ D QR LE+    R+ +   A      A SLE  L Q++  L 
Sbjct: 1639 GREEAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697

Query: 707  QRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASRED 766
              ++  +    E  +L ++L  +     + +     L+    +L+  L E QG   +  D
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757

Query: 767  TI--CLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQV 824
             +     Q E++  E A + + + K E  R  ++LE   +E    L ++  E A+KS   
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESAR--QQLERQNKELRSKLHEM--EGAVKS--- 1810

Query: 825  EHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELR 884
               +   AAL+ ++ +++EQ  Q     EA  + A +K         + K+ D +LKE+ 
Sbjct: 1811 -KFKSTIAALEAKIAQLEEQVEQ-----EAREKQAATK---------SLKQKDKKLKEI- 1854

Query: 885  QELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKE 944
              L+QV  E++ AE    +  +  A+V+Q    L+  L+ A++E   +  + + LQ + +
Sbjct: 1855 --LLQVEDERKMAEQYKEQAEKGNARVKQ----LKRQLEEAEEESQRINANRRKLQRELD 1908

Query: 945  QMVAVTEANEALKKQIEELQQEARKA-----ITEQKQKMRRLGSDLTSAQKEMKTK 995
            +    TE+NEA+ +++  L+ + R+      +  ++   RR+  +   +++E  T+
Sbjct: 1909 E---ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTR 1961



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 71/314 (22%), Positives = 147/314 (46%), Gaps = 38/314 (12%)

Query: 1163 KEEEDRQMKHLVQALQASLEK--EKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE----L 1216
            +EE D ++  ++ A QA       ++     ++Q+ A KV   +   + K  + +     
Sbjct: 779  EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 838

Query: 1217 SEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQA-ELAEARAQLQLLQKQLDEQ 1275
            ++VK  LQ      +++QA+ D+LQ  + K  Q+ A+ +  EL +  +QL   +  L EQ
Sbjct: 839  TKVKPLLQVTRQ-EEEMQAKEDELQ--KTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD--LTEQQGR-----KELEGLQQLLQNV 1328
            L  +     E E ++  +  K++E++ +  +++  L E++ R      E + + Q + ++
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 1329 KSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL----KLDLRRGAAKTRKE 1384
            + +LE  +      Q +K   +AK+ +L++ +  +  QN +L    KL   R +  T   
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015

Query: 1385 PKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQR 1444
             + E  + N  T +K        S++ EL      + KE         ++ +QE++ L+R
Sbjct: 1016 AEEEEKAKN-LTKLKNKH----ESMISEL---EVRLKKE---------EKSRQELEKLKR 1058

Query: 1445 QMEEHALTVHESLS 1458
            ++E  A   HE ++
Sbjct: 1059 KLEGDASDFHEQIA 1072


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  186 bits (471), Expect = 2e-46
 Identities = 226/1088 (20%), Positives = 471/1088 (43%), Gaps = 134/1088 (12%)

Query: 358  FPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL 417
            F  +K +LQ    E + Q +E   +    R         E+   E +++  Q+ +EK  L
Sbjct: 845  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ-----KAENELKELEQKHSQLTEEKNLL 899

Query: 418  EGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSC 477
            + QL+A     ++   E  E++ +LAA   +L+   E  H  + R +        L+   
Sbjct: 900  QEQLQA----ETELYAEAEEMRVRLAAKKQELE---EILHEMEARLEEEEDRGQQLQAER 952

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAK--VEDMQRSMLSKDNTVHD 535
              + + M DL+  LE + A+      +   AE + ++L  +  V D Q + LSK+  +  
Sbjct: 953  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL-- 1010

Query: 536  LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE 595
            L ++++ L + L + + +   LT      ++ IS L+   +  ++     ++ + +L+G+
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070

Query: 596  MA--HIQVGQMTQAGLLEHLKLENVSLSQQLTET-------------------------- 627
             +  H Q+  + QA + E LK++     ++L                             
Sbjct: 1071 ASDFHEQIADL-QAQIAE-LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128

Query: 628  ------------QHRSMKEKGRIAAQLQGIEA---DMLDQEAAFMQIQEAK----TMVEE 668
                        ++++ K+K  +  +L+ ++    D LD  A   +++  +    T++++
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 669  DLQRRLEEFEGE-RERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLT 727
             L       E + +E  Q+ A +   L +QLEQ K      D+  + L++E+ DL  +L 
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248

Query: 728  LTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
            +  +A Q  E     L+    ELQ++  + +   A   D +  LQNE   +   L  A+ 
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308

Query: 788  GKEELDRGARRLEEGTEETSETL-EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFL 846
               +L +    L    ++T E L E+ R++L + S ++  L++E  +L+ Q+ +  E   
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNV-STKLRQLEEERNSLQDQLDEEME--- 1364

Query: 847  QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHR 906
                          +K  L   +      L+ +L + +++L          E    R  +
Sbjct: 1365 --------------AKQNLERHIST----LNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

Query: 907  EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            E+  + Q   +        +K ++ ++  L  L  D +           L   +E+ Q++
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN-------QRQLVSNLEKKQRK 1459

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
              + + E+K    +   +   A+ E + K    E     L+R L+EAL AKE  +     
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREK----ETKALSLARALEEALEAKEELERTNKM 1515

Query: 1027 LRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE 1085
            L+A+     SS   + + +  LE   +A+      ++ +L+E+      EL+ + +  L 
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL----EDELQATEDAKLR 1571

Query: 1086 LEDELQESRG-FRKKIKRLEESNKKLALELEHEKGKL-TGLGQSNAALREHNSILETALA 1143
            LE  +Q  +G F + ++  +E N++   +L+ +  +  T L       R+  ++   A  
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE----RKQRALAAAAKK 1627

Query: 1144 KREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAG 1203
            K E DL  L LQ  + ++ +EE  +Q++ L QA     ++E E   + ++++ A    A 
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKL-QAQMKDFQRELEDARASRDEIFAT---AK 1683

Query: 1204 HNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQF---QAELAE 1260
             N +  K+   +L +++++L A E   ++   E ++L       ++E+A     +  L +
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-------AEELASSLSGRNALQD 1736

Query: 1261 ARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG 1320
             + +L+    QL+E+L ++  GN  ME +   V +  ++ + L  +L  TE+   ++ E 
Sbjct: 1737 EKRRLEARIAQLEEELEEEQ-GN--MEAMSDRVRKATQQAEQLSNEL-ATERSTAQKNES 1792

Query: 1321 LQQLLQNVKSELEMAQEDLSMTQKDKF-----MLQAKVSELKNNMKTLLQQNQQLKLDLR 1375
             +Q L+    EL     ++    K KF      L+AK+++L+  ++   ++ Q     L+
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1852

Query: 1376 RGAAKTRK 1383
            +   K ++
Sbjct: 1853 QKDKKLKE 1860



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/772 (21%), Positives = 308/772 (39%), Gaps = 111/772 (14%)

Query: 725  QLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784
            Q+T  +E +Q++E  L   +    + +  L EL+ + +        L  EK +L+  LQA
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ-------LTEEKNLLQEQLQA 905

Query: 785  AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
                  E +    RL    +E  E L ++   L  +  + + LQ E   + +QM  ++EQ
Sbjct: 906  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 845  F-----LQQKVMVEAYRRDATSK---------DQLISELKATRKRLDSELKELRQELMQV 890
                   +QK+ +E    +A  K         D   ++L   RK L+  + +L   L + 
Sbjct: 966  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025

Query: 891  HGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVT 950
              EK     +L   H  +      +++LE  L+  +K R E+E   + L+ D        
Sbjct: 1026 E-EKAKNLTKLKNKHESM------ISELEVRLKKEEKSRQELEKLKRKLEGDASDF---H 1075

Query: 951  EANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRL 1010
            E    L+ QI EL+ +  K   E +  + RL  ++      +K K +  E  +  L   L
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1134

Query: 1011 QEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSK-TLLEKELQEVI 1069
                AA+  A+ +   L  +  +  + L       A + EL+A    + T+L+K L E  
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194

Query: 1070 ALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN 1128
                 +++E R+K  +  +EL E    F++    L+++ + L  E     G+L  LGQ+ 
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254

Query: 1129 AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
              +      LE               QVQ +  +  + +R    L   +   L+ E E V
Sbjct: 1255 QEVEHKKKKLEA--------------QVQELQSKCSDGERARAELNDKVH-KLQNEVESV 1299

Query: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248
              +  +     ++     +   + S +L + ++ LQ  E   QKL       Q+ E ++S
Sbjct: 1300 TGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQ--EETRQKLNVSTKLRQLEEERNS 1354

Query: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD 1308
                               LQ QLDE++  +    + +  L  ++   ++++Q     ++
Sbjct: 1355 -------------------LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395

Query: 1309 LTEQ---QGRKELEGLQQL----------LQNVKSELEMAQEDLSMTQKDKFMLQAKVSE 1355
              E+   + +KE+E L Q           L+  K+ L+   +DL +   ++  L + + +
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455

Query: 1356 LKNNMKTLLQQNQQLK---LDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEE 1412
             +     LL + + +     D R  A    +E + +A S               A  LEE
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL--------------ARALEE 1501

Query: 1413 LLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLE 1464
             L      +KE L+  N   + LK EM+ L    ++    VHE   S   LE
Sbjct: 1502 ALE-----AKEELERTN---KMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545



 Score =  115 bits (288), Expect = 3e-25
 Identities = 195/956 (20%), Positives = 388/956 (40%), Gaps = 121/956 (12%)

Query: 100  FHDNLRKSQGTSAEGSVR-KEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWL 158
            FH+ +   Q   AE  ++  +  + L+ +L   + ++   ++ L   +E +  +     L
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD---L 1130

Query: 159  EEQLKQYRVKRQQERSSQ-------PATKTRLFSTLDP-----ELMLNPENLPRASTLAM 206
            +E L   R  R +    +        A KT L  TLD      EL    E        A+
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 207  TKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGNVPAP 266
             +E       V    +  +  +     + +  K +K     + +T +    +  G +   
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 267  DSTKGSLKQNRSSAASVVSEISLSPDTDDRL-----ENTSLAGDSVSEVDGNDSDSSSYS 321
               K  ++  +    + V E+       +R      +      + V  V G  +++   +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 322  SASTRGTYGILSKTVGTQDTPYMVNGQEIPADT-LGQFPSIKDVLQAAAAEHQDQGQEVN 380
                +    + S+   TQ+       Q++   T L Q    ++ LQ    E  +  Q + 
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370

Query: 381  GEVRSRRDSICSSVSLESSAAETQEEMLQ----VLKEKMRLEGQLEALSLEASQALKEKA 436
              + +    +  S       A T E + +      KE   L  Q E  +    +  K K 
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430

Query: 437  ELQAQLAALSTKLQAQVECSHSSQQRQ---DSLSSEVDTLKQSCWD-LERAMTDLQNMLE 492
             LQ +L  L   L  Q +   + +++Q   D L +E   +     D  +RA  + +   E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-E 1489

Query: 493  AKNASLASSNNDLQVAEEQYQR----LMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQ 548
             K  SLA +  +   A+E+ +R    L A++ED+  S       VH+L +   AL++Q++
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 549  QVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAG 608
            +++ +   L  +L+A++                     +A++RL+  M  ++ GQ  +  
Sbjct: 1550 EMKTQLEELEDELQATE---------------------DAKLRLEVNMQALK-GQFERD- 1586

Query: 609  LLEHLKLENVSLSQQLTETQHR-------SMKEKGRIAAQLQGIEADMLD---------- 651
             L+    +N    +QL    H          K++   AA  + +E D+ D          
Sbjct: 1587 -LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645

Query: 652  -QEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADS----AASLEQQLEQVKLTLL 706
             +E A  Q+++ +  ++ D QR LE+    R+ +   A      A SLE  L Q++  L 
Sbjct: 1646 GREEAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 707  QRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASRED 766
              ++  +    E  +L ++L  +     + +     L+    +L+  L E QG   +  D
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764

Query: 767  TI--CLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQV 824
             +     Q E++  E A + + + K E  R  ++LE   +E    L ++  E A+KS   
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESAR--QQLERQNKELRSKLHEM--EGAVKS--- 1817

Query: 825  EHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELR 884
               +   AAL+ ++ +++EQ  Q     EA  + A +K         + K+ D +LKE+ 
Sbjct: 1818 -KFKSTIAALEAKIAQLEEQVEQ-----EAREKQAATK---------SLKQKDKKLKEI- 1861

Query: 885  QELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKE 944
              L+QV  E++ AE    +  +  A+V+Q    L+  L+ A++E   +  + + LQ + +
Sbjct: 1862 --LLQVEDERKMAEQYKEQAEKGNARVKQ----LKRQLEEAEEESQRINANRRKLQRELD 1915

Query: 945  QMVAVTEANEALKKQIEELQQEARKA-----ITEQKQKMRRLGSDLTSAQKEMKTK 995
            +    TE+NEA+ +++  L+ + R+      +  ++   RR+  +   +++E  T+
Sbjct: 1916 E---ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTR 1968



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 71/314 (22%), Positives = 147/314 (46%), Gaps = 38/314 (12%)

Query: 1163 KEEEDRQMKHLVQALQASLEK--EKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE----L 1216
            +EE D ++  ++ A QA       ++     ++Q+ A KV   +   + K  + +     
Sbjct: 786  EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845

Query: 1217 SEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQA-ELAEARAQLQLLQKQLDEQ 1275
            ++VK  LQ      +++QA+ D+LQ  + K  Q+ A+ +  EL +  +QL   +  L EQ
Sbjct: 846  TKVKPLLQVTRQ-EEEMQAKEDELQ--KTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD--LTEQQGR-----KELEGLQQLLQNV 1328
            L  +     E E ++  +  K++E++ +  +++  L E++ R      E + + Q + ++
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 1329 KSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL----KLDLRRGAAKTRKE 1384
            + +LE  +      Q +K   +AK+ +L++ +  +  QN +L    KL   R +  T   
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022

Query: 1385 PKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQR 1444
             + E  + N  T +K        S++ EL      + KE         ++ +QE++ L+R
Sbjct: 1023 AEEEEKAKN-LTKLKNKH----ESMISEL---EVRLKKE---------EKSRQELEKLKR 1065

Query: 1445 QMEEHALTVHESLS 1458
            ++E  A   HE ++
Sbjct: 1066 KLEGDASDFHEQIA 1079


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  186 bits (471), Expect = 2e-46
 Identities = 226/1088 (20%), Positives = 471/1088 (43%), Gaps = 134/1088 (12%)

Query: 358  FPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL 417
            F  +K +LQ    E + Q +E   +    R         E+   E +++  Q+ +EK  L
Sbjct: 845  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ-----KAENELKELEQKHSQLTEEKNLL 899

Query: 418  EGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSC 477
            + QL+A     ++   E  E++ +LAA   +L+   E  H  + R +        L+   
Sbjct: 900  QEQLQA----ETELYAEAEEMRVRLAAKKQELE---EILHEMEARLEEEEDRGQQLQAER 952

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAK--VEDMQRSMLSKDNTVHD 535
              + + M DL+  LE + A+      +   AE + ++L  +  V D Q + LSK+  +  
Sbjct: 953  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL-- 1010

Query: 536  LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE 595
            L ++++ L + L + + +   LT      ++ IS L+   +  ++     ++ + +L+G+
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070

Query: 596  MA--HIQVGQMTQAGLLEHLKLENVSLSQQLTET-------------------------- 627
             +  H Q+  + QA + E LK++     ++L                             
Sbjct: 1071 ASDFHEQIADL-QAQIAE-LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128

Query: 628  ------------QHRSMKEKGRIAAQLQGIEA---DMLDQEAAFMQIQEAK----TMVEE 668
                        ++++ K+K  +  +L+ ++    D LD  A   +++  +    T++++
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 669  DLQRRLEEFEGE-RERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLT 727
             L       E + +E  Q+ A +   L +QLEQ K      D+  + L++E+ DL  +L 
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248

Query: 728  LTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
            +  +A Q  E     L+    ELQ++  + +   A   D +  LQNE   +   L  A+ 
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308

Query: 788  GKEELDRGARRLEEGTEETSETL-EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFL 846
               +L +    L    ++T E L E+ R++L + S ++  L++E  +L+ Q+ +  E   
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNV-STKLRQLEEERNSLQDQLDEEME--- 1364

Query: 847  QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHR 906
                          +K  L   +      L+ +L + +++L          E    R  +
Sbjct: 1365 --------------AKQNLERHIST----LNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

Query: 907  EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            E+  + Q   +        +K ++ ++  L  L  D +           L   +E+ Q++
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN-------QRQLVSNLEKKQRK 1459

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
              + + E+K    +   +   A+ E + K    E     L+R L+EAL AKE  +     
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREK----ETKALSLARALEEALEAKEELERTNKM 1515

Query: 1027 LRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE 1085
            L+A+     SS   + + +  LE   +A+      ++ +L+E+      EL+ + +  L 
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL----EDELQATEDAKLR 1571

Query: 1086 LEDELQESRG-FRKKIKRLEESNKKLALELEHEKGKL-TGLGQSNAALREHNSILETALA 1143
            LE  +Q  +G F + ++  +E N++   +L+ +  +  T L       R+  ++   A  
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE----RKQRALAAAAKK 1627

Query: 1144 KREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAG 1203
            K E DL  L LQ  + ++ +EE  +Q++ L QA     ++E E   + ++++ A    A 
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKL-QAQMKDFQRELEDARASRDEIFAT---AK 1683

Query: 1204 HNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQF---QAELAE 1260
             N +  K+   +L +++++L A E   ++   E ++L       ++E+A     +  L +
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-------AEELASSLSGRNALQD 1736

Query: 1261 ARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG 1320
             + +L+    QL+E+L ++  GN  ME +   V +  ++ + L  +L  TE+   ++ E 
Sbjct: 1737 EKRRLEARIAQLEEELEEEQ-GN--MEAMSDRVRKATQQAEQLSNEL-ATERSTAQKNES 1792

Query: 1321 LQQLLQNVKSELEMAQEDLSMTQKDKF-----MLQAKVSELKNNMKTLLQQNQQLKLDLR 1375
             +Q L+    EL     ++    K KF      L+AK+++L+  ++   ++ Q     L+
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1852

Query: 1376 RGAAKTRK 1383
            +   K ++
Sbjct: 1853 QKDKKLKE 1860



 Score =  173 bits (438), Expect = 1e-42
 Identities = 208/963 (21%), Positives = 426/963 (44%), Gaps = 95/963 (9%)

Query: 370  AEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEAS 429
            AE +++ + +  +++++ +S+ S + +     E   + L+ LK K  LEG       +AS
Sbjct: 1023 AEEEEKAKNLT-KLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEG-------DAS 1072

Query: 430  QALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQN 489
               ++ A+LQAQ+A L  +L  + E   ++  R D   ++ +   +   +LE  ++DLQ 
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 490  MLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQ 549
             L+++ A+   +    +   E+ + L  ++ED   S  ++        Q++T L+  L +
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 550  VQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGL 609
                      + ++ +A++   Q +RQ + Q +    E   + +   A++   + T    
Sbjct: 1193 ----------ETRSHEAQV---QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239

Query: 610  LEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEED 669
               L  E   L Q   E +H+    K ++ AQ+Q +++   D E A  ++ +    ++ +
Sbjct: 1240 NADLAGELRVLGQAKQEVEHK----KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295

Query: 670  LQR---RLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQ-------LEALQQEH 719
            ++     L E EG+  +L   A   ASL  QL+  +  L +  +Q       L  L++E 
Sbjct: 1296 VESVTGMLNEAEGKAIKL---AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352

Query: 720  LDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILE 779
              L  QL    EA Q+ E+ +  L     + + +L +      + E+     Q E   L 
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412

Query: 780  AALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQ 839
               +   +  ++L++   RL++  ++    L+  R+ ++     +E  Q++   L  + +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS----NLEKKQRKFDQLLAEEK 1468

Query: 840  KIKEQFLQQKVMVEAYRRDATSKDQLIS-----------ELKATRKRLDSELKELRQELM 888
             I  ++  ++   EA  R+  +K   ++           EL+ T K L +E+++L     
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSL--QFDKEQM 946
             V       E     L  ++ +++  + +LE  LQ+ +  +  +E ++Q+L  QF+++ +
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD-L 1587

Query: 947  VAVTEANEALKKQIE-ELQQEARKAITEQKQKM------RRLGSDLTSAQKEMKTKHKAY 999
             A  E NE  ++Q++ +L +   +   E+KQ+       ++L  DL   + +  +  K  
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647

Query: 1000 ENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHER-IQALEAELQAVSHSK 1058
            E A+    ++L++  A  +    EL   RA      ++   +E+  ++LEA+L  +    
Sbjct: 1648 EEAI----KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 1059 TLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEK 1118
               E+  ++   L  +EL E     L   + LQ+ +      +RLE    +L  ELE E+
Sbjct: 1704 AAAERARKQA-DLEKEELAEELASSLSGRNALQDEK------RRLEARIAQLEEELEEEQ 1756

Query: 1119 GKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQ 1178
            G +  +        +    L   LA  E    Q N   +  L+R+ +E R   H ++   
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815

Query: 1179 ASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQ------- 1231
             S  K K  + +L+ ++A  + +     R  +AA+  L +  K+L  KE L+Q       
Sbjct: 1816 KS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL--KEILLQVEDERKM 1871

Query: 1232 ----KLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEME 1287
                K QAE  + ++++ K   E A+ +++     A  + LQ++LDE         +E+ 
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEESQ--RINANRRKLQRELDEATESNEAMGREVN 1929

Query: 1288 NLK 1290
             LK
Sbjct: 1930 ALK 1932



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/772 (21%), Positives = 308/772 (39%), Gaps = 111/772 (14%)

Query: 725  QLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784
            Q+T  +E +Q++E  L   +    + +  L EL+ + +        L  EK +L+  LQA
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ-------LTEEKNLLQEQLQA 905

Query: 785  AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
                  E +    RL    +E  E L ++   L  +  + + LQ E   + +QM  ++EQ
Sbjct: 906  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 845  F-----LQQKVMVEAYRRDATSK---------DQLISELKATRKRLDSELKELRQELMQV 890
                   +QK+ +E    +A  K         D   ++L   RK L+  + +L   L + 
Sbjct: 966  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025

Query: 891  HGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVT 950
              EK     +L   H  +      +++LE  L+  +K R E+E   + L+ D        
Sbjct: 1026 E-EKAKNLTKLKNKHESM------ISELEVRLKKEEKSRQELEKLKRKLEGDASDF---H 1075

Query: 951  EANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRL 1010
            E    L+ QI EL+ +  K   E +  + RL  ++      +K K +  E  +  L   L
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1134

Query: 1011 QEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSK-TLLEKELQEVI 1069
                AA+  A+ +   L  +  +  + L       A + EL+A    + T+L+K L E  
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194

Query: 1070 ALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN 1128
                 +++E R+K  +  +EL E    F++    L+++ + L  E     G+L  LGQ+ 
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254

Query: 1129 AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
              +      LE               QVQ +  +  + +R    L   +   L+ E E V
Sbjct: 1255 QEVEHKKKKLEA--------------QVQELQSKCSDGERARAELNDKVH-KLQNEVESV 1299

Query: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248
              +  +     ++     +   + S +L + ++ LQ  E   QKL       Q+ E ++S
Sbjct: 1300 TGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQ--EETRQKLNVSTKLRQLEEERNS 1354

Query: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD 1308
                               LQ QLDE++  +    + +  L  ++   ++++Q     ++
Sbjct: 1355 -------------------LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395

Query: 1309 LTEQ---QGRKELEGLQQL----------LQNVKSELEMAQEDLSMTQKDKFMLQAKVSE 1355
              E+   + +KE+E L Q           L+  K+ L+   +DL +   ++  L + + +
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455

Query: 1356 LKNNMKTLLQQNQQLK---LDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEE 1412
             +     LL + + +     D R  A    +E + +A S               A  LEE
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL--------------ARALEE 1501

Query: 1413 LLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLE 1464
             L      +KE L+  N   + LK EM+ L    ++    VHE   S   LE
Sbjct: 1502 ALE-----AKEELERTN---KMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 71/314 (22%), Positives = 147/314 (46%), Gaps = 38/314 (12%)

Query: 1163 KEEEDRQMKHLVQALQASLEK--EKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE----L 1216
            +EE D ++  ++ A QA       ++     ++Q+ A KV   +   + K  + +     
Sbjct: 786  EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845

Query: 1217 SEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQA-ELAEARAQLQLLQKQLDEQ 1275
            ++VK  LQ      +++QA+ D+LQ  + K  Q+ A+ +  EL +  +QL   +  L EQ
Sbjct: 846  TKVKPLLQVTRQ-EEEMQAKEDELQ--KTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD--LTEQQGR-----KELEGLQQLLQNV 1328
            L  +     E E ++  +  K++E++ +  +++  L E++ R      E + + Q + ++
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 1329 KSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL----KLDLRRGAAKTRKE 1384
            + +LE  +      Q +K   +AK+ +L++ +  +  QN +L    KL   R +  T   
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022

Query: 1385 PKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQR 1444
             + E  + N  T +K        S++ EL      + KE         ++ +QE++ L+R
Sbjct: 1023 AEEEEKAKN-LTKLKNKH----ESMISEL---EVRLKKE---------EKSRQELEKLKR 1065

Query: 1445 QMEEHALTVHESLS 1458
            ++E  A   HE ++
Sbjct: 1066 KLEGDASDFHEQIA 1079



 Score = 44.3 bits (103), Expect = 9e-04
 Identities = 49/201 (24%), Positives = 92/201 (45%), Gaps = 22/201 (10%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSI----------CSSVSLESSAAETQEEMLQVLKEK 414
            L+A  A+ +++ +E  G + +  D +           + ++ E S A+  E   Q L+ +
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800

Query: 415  MRLEGQLEALSLEASQALKEKAELQAQLAALSTK---LQAQVEC-SHSSQQRQDSLSSEV 470
             +   +L +   E   A+K K   ++ +AAL  K   L+ QVE  +   Q    SL  + 
Sbjct: 1801 NK---ELRSKLHEMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

Query: 471  DTLKQSCWDLE--RAMTD-LQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSML 527
              LK+    +E  R M +  +   E  NA +      L+ AEE+ QR+ A    +QR + 
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915

Query: 528  SKDNTVHDLRQQMTALQSQLQ 548
                +   + +++ AL+S+L+
Sbjct: 1916 EATESNEAMGREVNALKSKLR 1936


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  186 bits (471), Expect = 2e-46
 Identities = 226/1088 (20%), Positives = 471/1088 (43%), Gaps = 134/1088 (12%)

Query: 358  FPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL 417
            F  +K +LQ    E + Q +E   +    R         E+   E +++  Q+ +EK  L
Sbjct: 838  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ-----KAENELKELEQKHSQLTEEKNLL 892

Query: 418  EGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSC 477
            + QL+A     ++   E  E++ +LAA   +L+   E  H  + R +        L+   
Sbjct: 893  QEQLQA----ETELYAEAEEMRVRLAAKKQELE---EILHEMEARLEEEEDRGQQLQAER 945

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAK--VEDMQRSMLSKDNTVHD 535
              + + M DL+  LE + A+      +   AE + ++L  +  V D Q + LSK+  +  
Sbjct: 946  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL-- 1003

Query: 536  LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE 595
            L ++++ L + L + + +   LT      ++ IS L+   +  ++     ++ + +L+G+
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063

Query: 596  MA--HIQVGQMTQAGLLEHLKLENVSLSQQLTET-------------------------- 627
             +  H Q+  + QA + E LK++     ++L                             
Sbjct: 1064 ASDFHEQIADL-QAQIAE-LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121

Query: 628  ------------QHRSMKEKGRIAAQLQGIEA---DMLDQEAAFMQIQEAK----TMVEE 668
                        ++++ K+K  +  +L+ ++    D LD  A   +++  +    T++++
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 669  DLQRRLEEFEGE-RERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLT 727
             L       E + +E  Q+ A +   L +QLEQ K      D+  + L++E+ DL  +L 
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241

Query: 728  LTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
            +  +A Q  E     L+    ELQ++  + +   A   D +  LQNE   +   L  A+ 
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301

Query: 788  GKEELDRGARRLEEGTEETSETL-EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFL 846
               +L +    L    ++T E L E+ R++L + S ++  L++E  +L+ Q+ +  E   
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNV-STKLRQLEEERNSLQDQLDEEME--- 1357

Query: 847  QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHR 906
                          +K  L   +      L+ +L + +++L          E    R  +
Sbjct: 1358 --------------AKQNLERHIST----LNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399

Query: 907  EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            E+  + Q   +        +K ++ ++  L  L  D +           L   +E+ Q++
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN-------QRQLVSNLEKKQRK 1452

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
              + + E+K    +   +   A+ E + K    E     L+R L+EAL AKE  +     
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREK----ETKALSLARALEEALEAKEELERTNKM 1508

Query: 1027 LRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE 1085
            L+A+     SS   + + +  LE   +A+      ++ +L+E+      EL+ + +  L 
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL----EDELQATEDAKLR 1564

Query: 1086 LEDELQESRG-FRKKIKRLEESNKKLALELEHEKGKL-TGLGQSNAALREHNSILETALA 1143
            LE  +Q  +G F + ++  +E N++   +L+ +  +  T L       R+  ++   A  
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE----RKQRALAAAAKK 1620

Query: 1144 KREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAG 1203
            K E DL  L LQ  + ++ +EE  +Q++ L QA     ++E E   + ++++ A    A 
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKL-QAQMKDFQRELEDARASRDEIFAT---AK 1676

Query: 1204 HNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQF---QAELAE 1260
             N +  K+   +L +++++L A E   ++   E ++L       ++E+A     +  L +
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-------AEELASSLSGRNALQD 1729

Query: 1261 ARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG 1320
             + +L+    QL+E+L ++  GN  ME +   V +  ++ + L  +L  TE+   ++ E 
Sbjct: 1730 EKRRLEARIAQLEEELEEEQ-GN--MEAMSDRVRKATQQAEQLSNEL-ATERSTAQKNES 1785

Query: 1321 LQQLLQNVKSELEMAQEDLSMTQKDKF-----MLQAKVSELKNNMKTLLQQNQQLKLDLR 1375
             +Q L+    EL     ++    K KF      L+AK+++L+  ++   ++ Q     L+
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK 1845

Query: 1376 RGAAKTRK 1383
            +   K ++
Sbjct: 1846 QKDKKLKE 1853



 Score =  173 bits (438), Expect = 1e-42
 Identities = 208/963 (21%), Positives = 426/963 (44%), Gaps = 95/963 (9%)

Query: 370  AEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEAS 429
            AE +++ + +  +++++ +S+ S + +     E   + L+ LK K  LEG       +AS
Sbjct: 1016 AEEEEKAKNLT-KLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEG-------DAS 1065

Query: 430  QALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQN 489
               ++ A+LQAQ+A L  +L  + E   ++  R D   ++ +   +   +LE  ++DLQ 
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 490  MLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQ 549
             L+++ A+   +    +   E+ + L  ++ED   S  ++        Q++T L+  L +
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 550  VQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGL 609
                      + ++ +A++   Q +RQ + Q +    E   + +   A++   + T    
Sbjct: 1186 ----------ETRSHEAQV---QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232

Query: 610  LEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEED 669
               L  E   L Q   E +H+    K ++ AQ+Q +++   D E A  ++ +    ++ +
Sbjct: 1233 NADLAGELRVLGQAKQEVEHK----KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288

Query: 670  LQR---RLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQ-------LEALQQEH 719
            ++     L E EG+  +L   A   ASL  QL+  +  L +  +Q       L  L++E 
Sbjct: 1289 VESVTGMLNEAEGKAIKL---AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345

Query: 720  LDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILE 779
              L  QL    EA Q+ E+ +  L     + + +L +      + E+     Q E   L 
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405

Query: 780  AALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQ 839
               +   +  ++L++   RL++  ++    L+  R+ ++     +E  Q++   L  + +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS----NLEKKQRKFDQLLAEEK 1461

Query: 840  KIKEQFLQQKVMVEAYRRDATSKDQLIS-----------ELKATRKRLDSELKELRQELM 888
             I  ++  ++   EA  R+  +K   ++           EL+ T K L +E+++L     
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSL--QFDKEQM 946
             V       E     L  ++ +++  + +LE  LQ+ +  +  +E ++Q+L  QF+++ +
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD-L 1580

Query: 947  VAVTEANEALKKQIE-ELQQEARKAITEQKQKM------RRLGSDLTSAQKEMKTKHKAY 999
             A  E NE  ++Q++ +L +   +   E+KQ+       ++L  DL   + +  +  K  
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640

Query: 1000 ENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHER-IQALEAELQAVSHSK 1058
            E A+    ++L++  A  +    EL   RA      ++   +E+  ++LEA+L  +    
Sbjct: 1641 EEAI----KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 1059 TLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEK 1118
               E+  ++   L  +EL E     L   + LQ+ +      +RLE    +L  ELE E+
Sbjct: 1697 AAAERARKQA-DLEKEELAEELASSLSGRNALQDEK------RRLEARIAQLEEELEEEQ 1749

Query: 1119 GKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQ 1178
            G +  +        +    L   LA  E    Q N   +  L+R+ +E R   H ++   
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808

Query: 1179 ASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQ------- 1231
             S  K K  + +L+ ++A  + +     R  +AA+  L +  K+L  KE L+Q       
Sbjct: 1809 KS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL--KEILLQVEDERKM 1864

Query: 1232 ----KLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEME 1287
                K QAE  + ++++ K   E A+ +++     A  + LQ++LDE         +E+ 
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEESQ--RINANRRKLQRELDEATESNEAMGREVN 1922

Query: 1288 NLK 1290
             LK
Sbjct: 1923 ALK 1925



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/772 (21%), Positives = 308/772 (39%), Gaps = 111/772 (14%)

Query: 725  QLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784
            Q+T  +E +Q++E  L   +    + +  L EL+ + +        L  EK +L+  LQA
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ-------LTEEKNLLQEQLQA 898

Query: 785  AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
                  E +    RL    +E  E L ++   L  +  + + LQ E   + +QM  ++EQ
Sbjct: 899  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 845  F-----LQQKVMVEAYRRDATSK---------DQLISELKATRKRLDSELKELRQELMQV 890
                   +QK+ +E    +A  K         D   ++L   RK L+  + +L   L + 
Sbjct: 959  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018

Query: 891  HGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVT 950
              EK     +L   H  +      +++LE  L+  +K R E+E   + L+ D        
Sbjct: 1019 E-EKAKNLTKLKNKHESM------ISELEVRLKKEEKSRQELEKLKRKLEGDASDF---H 1068

Query: 951  EANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRL 1010
            E    L+ QI EL+ +  K   E +  + RL  ++      +K K +  E  +  L   L
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1127

Query: 1011 QEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSK-TLLEKELQEVI 1069
                AA+  A+ +   L  +  +  + L       A + EL+A    + T+L+K L E  
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187

Query: 1070 ALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN 1128
                 +++E R+K  +  +EL E    F++    L+++ + L  E     G+L  LGQ+ 
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247

Query: 1129 AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
              +      LE               QVQ +  +  + +R    L   +   L+ E E V
Sbjct: 1248 QEVEHKKKKLEA--------------QVQELQSKCSDGERARAELNDKVH-KLQNEVESV 1292

Query: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248
              +  +     ++     +   + S +L + ++ LQ  E   QKL       Q+ E ++S
Sbjct: 1293 TGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQ--EETRQKLNVSTKLRQLEEERNS 1347

Query: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD 1308
                               LQ QLDE++  +    + +  L  ++   ++++Q     ++
Sbjct: 1348 -------------------LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388

Query: 1309 LTEQ---QGRKELEGLQQL----------LQNVKSELEMAQEDLSMTQKDKFMLQAKVSE 1355
              E+   + +KE+E L Q           L+  K+ L+   +DL +   ++  L + + +
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448

Query: 1356 LKNNMKTLLQQNQQLK---LDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEE 1412
             +     LL + + +     D R  A    +E + +A S               A  LEE
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL--------------ARALEE 1494

Query: 1413 LLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLE 1464
             L      +KE L+  N   + LK EM+ L    ++    VHE   S   LE
Sbjct: 1495 ALE-----AKEELERTN---KMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 71/314 (22%), Positives = 147/314 (46%), Gaps = 38/314 (12%)

Query: 1163 KEEEDRQMKHLVQALQASLEK--EKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE----L 1216
            +EE D ++  ++ A QA       ++     ++Q+ A KV   +   + K  + +     
Sbjct: 779  EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 838

Query: 1217 SEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQA-ELAEARAQLQLLQKQLDEQ 1275
            ++VK  LQ      +++QA+ D+LQ  + K  Q+ A+ +  EL +  +QL   +  L EQ
Sbjct: 839  TKVKPLLQVTRQ-EEEMQAKEDELQ--KTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD--LTEQQGR-----KELEGLQQLLQNV 1328
            L  +     E E ++  +  K++E++ +  +++  L E++ R      E + + Q + ++
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 1329 KSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL----KLDLRRGAAKTRKE 1384
            + +LE  +      Q +K   +AK+ +L++ +  +  QN +L    KL   R +  T   
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015

Query: 1385 PKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQR 1444
             + E  + N  T +K        S++ EL      + KE         ++ +QE++ L+R
Sbjct: 1016 AEEEEKAKN-LTKLKNKH----ESMISEL---EVRLKKE---------EKSRQELEKLKR 1058

Query: 1445 QMEEHALTVHESLS 1458
            ++E  A   HE ++
Sbjct: 1059 KLEGDASDFHEQIA 1072



 Score = 44.3 bits (103), Expect = 9e-04
 Identities = 49/201 (24%), Positives = 92/201 (45%), Gaps = 22/201 (10%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSI----------CSSVSLESSAAETQEEMLQVLKEK 414
            L+A  A+ +++ +E  G + +  D +           + ++ E S A+  E   Q L+ +
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793

Query: 415  MRLEGQLEALSLEASQALKEKAELQAQLAALSTK---LQAQVEC-SHSSQQRQDSLSSEV 470
             +   +L +   E   A+K K   ++ +AAL  K   L+ QVE  +   Q    SL  + 
Sbjct: 1794 NK---ELRSKLHEMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848

Query: 471  DTLKQSCWDLE--RAMTD-LQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSML 527
              LK+    +E  R M +  +   E  NA +      L+ AEE+ QR+ A    +QR + 
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908

Query: 528  SKDNTVHDLRQQMTALQSQLQ 548
                +   + +++ AL+S+L+
Sbjct: 1909 EATESNEAMGREVNALKSKLR 1929


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  185 bits (469), Expect = 3e-46
 Identities = 228/1070 (21%), Positives = 458/1070 (42%), Gaps = 119/1070 (11%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E   AE +E + +V     +     EA +   +QA +E  ELQ ++     ++  + E +
Sbjct: 1352 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA 1408

Query: 457  HSSQQRQDSLSSEVDTLKQS-----------CWDLERAMTDLQNMLEAKNASLASSNNDL 505
              +QQ++ S+  E+  L+QS               ER+   ++  +      L ++    
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
              AE + Q L A+ E+ +            LR+Q+     + +Q ++E   L S++KA +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE---LASRVKA-E 1524

Query: 566  AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLT 625
            AE +         ++Q AL     +RLQ E A  ++ Q      +E  +   V+L     
Sbjct: 1525 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQR 1572

Query: 626  ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA---KTMVEEDLQRRLEEFEGERE 682
              +     ++   A +   +E  + ++  A  Q++E    +   + + +R  EE E E E
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 683  RLQRMADSAASLEQQLEQV----KLTLLQRDQQLEALQQE-------HLDLMKQLTLTQE 731
            R Q  A+ A  L  Q E+V     L   + ++Q E  ++E           ++Q  L ++
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 732  ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
             L+ + Q  +         +  L  L+ E    E    LL+ E   L+    AA   ++E
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 792  LDRGARRLE-----------EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            L+    ++               EE+  T EK ++ L  ++G+   L +E A L+   ++
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRT 896
             K Q  +Q    +A R+ A ++  L  +L    +ATR + ++E+  L+++  +    +R 
Sbjct: 1813 AKRQ--RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA-LKEKEAENERLRRL 1869

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE--------METHLQSLQFDKEQMVA 948
            AE E  +  R   Q  QH AD+E  L   +K  D         +E  L+  +  +E+++A
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929

Query: 949  V----------------------TEANEALK-KQIEELQQEARKAITEQKQKMRRLGSDL 985
            +                      + A + L+ K+  EL+   ++ +  ++++ RR   + 
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989

Query: 986  T----SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG-QLRAQGGSSDSSLAL 1040
                 +A++E   + KA    V  L  +++EA   +E A+ E   QL+    ++   L  
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049

Query: 1041 HER-----IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095
             E+     +Q  E ELQ     +  +  +L+       +  EE+ E  ++ E E  +SR 
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109

Query: 1096 FRKKIKRLEESNKKLA---LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
              ++ +RL++S ++ A    + +    KL    +  AA R      + AL +++A   ++
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEM 2167

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
                +   Q   ++  Q++  +  L+  LE+   + N L E++   K EA    R     
Sbjct: 2168 EKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226

Query: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
              EL  V+ +++    L  +++AE   L +R+  ++Q   Q +AE            KQ+
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK----------MKQV 2276

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
             E+ ++  V  QE   L+   ++   + ++L +++   + Q  +E   L+   + ++ + 
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            E+AQE     Q+DK  +  +++E     +  L+  +Q +L++   A + +
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386



 Score =  180 bits (456), Expect = 1e-44
 Identities = 270/1151 (23%), Positives = 491/1151 (42%), Gaps = 185/1151 (16%)

Query: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
            Q  A   + Q Q+ +   R     + S V  E+ AA  ++  LQ L+E   L  Q E   
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAE 1549

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
                QA  E+A  Q Q+A  + +  A+ E     Q ++ S + +   L++S  +   A+ 
Sbjct: 1550 RRLRQAEVERAR-QVQVALETAQRSAEAEL----QSKRASFAEKTAQLERSLQEEHVAVA 1604

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD---------- 535
             L+   E +    A +    + AE + +R   K  +  R  L  +               
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 536  -------------------LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
                               +RQ+  A Q   +Q QL   T   +L A Q E+  L++  +
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETE 1723

Query: 577  WYQQQLALAQEARVRLQGEMAHI-QVGQMTQAGLLE-HLKLENVSLSQQLTETQHRSMKE 634
              +QQ  L +E   RLQ E A   Q  Q  +A L +   ++E +  S+   E + RS  E
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783

Query: 635  KGRIAAQLQGIEADMLDQEAAFMQI--QEAKT---MVEEDLQRR---------------- 673
            K +   + +      L +EAA ++   +EAK    + EED  R+                
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843

Query: 674  ------------LEEFEGERERLQRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQ 717
                        L+E E E ERL+R+A+  A     LE+Q  Q K  + +R  QL     
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 718  EHLDLMKQLTLTQEALQSR---EQSLDALQTHYDELQARLGELQGEA----ASREDTICL 770
              L+  +Q  L ++ L+ R   E+ + AL+  +++  A   EL+ E     ++ EDT  L
Sbjct: 1904 SELE--RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT--L 1959

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
               E+  LEAA Q   + +EE     RR  E  E   ++L    E    +   +E +++ 
Sbjct: 1960 RSKEQAELEAARQRQLAAEEE-----RRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
             A ++ + ++++E+  Q+        ++A  K +L +E KA    +  + +EL+Q L Q 
Sbjct: 2015 KAKVE-EARRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2072

Query: 891  HG--EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                ++   EAE +R   E A+  +  A+ E     A + R ++E   +  Q  +EQ  A
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR 1008
              +A  A +K  +E +QEA +    ++  +R+      +A  EM+ KHK +         
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QAADAEME-KHKKFA-------- 2174

Query: 1009 RLQEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKEL-- 1065
              ++ L  K   + EL  LR Q   +D     L E +Q L+AE    +  ++ +E+EL  
Sbjct: 2175 --EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232

Query: 1066 -----QEVIALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKG 1119
                 +E+  L ++   E+R  +L  +D  Q   +   +K+K++ E   +L++  + E  
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAA 2291

Query: 1120 KLTGLGQSNAA---------LREH-NSILETALAKREADLVQLNLQVQAVLQRKEEEDR- 1168
            +L  L + + A         L+E   ++ E    K EA+L+Q   ++     R+ +ED+ 
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351

Query: 1169 ----QMKHLVQALQASLEKEKEK-------VNSLKEQVAA---AKVEAGHNRRHFKAASL 1214
                Q+    Q  Q +LE E+++          LK +VA    A+  A  + + F+  + 
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 1215 ELSEV--KKELQAKEHL-------VQKLQAEADDLQIREG-----------KHSQEIAQF 1254
            E+ E   + EL  +E +       +Q+ Q++ D  ++RE            +   ++ Q 
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2471

Query: 1255 QAELAEARAQLQLLQK----------QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
            ++E  +   Q QLLQ+          + D  L ++    QE   L+     +  + Q L+
Sbjct: 2472 KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR 2531

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
            ++    +QQ  +E + L   ++  +     A+E +   Q++   LQ    + +   + L 
Sbjct: 2532 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQEELLA 2588

Query: 1365 QQNQQLKLDLR 1375
            ++NQ+L+  L+
Sbjct: 2589 EENQRLREQLQ 2599



 Score =  155 bits (392), Expect = 3e-37
 Identities = 253/1169 (21%), Positives = 477/1169 (40%), Gaps = 174/1169 (14%)

Query: 393  SVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQALKEKAELQAQLA-----AL 445
            ++SL     +  EE+L+  +E+++    + A    LEA++A  +K   QA+       AL
Sbjct: 1090 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1149

Query: 446  STKLQAQVECSHSSQQRQDSLSSEVDTLKQSC------WDLERAMTDL-QNMLEAKNASL 498
              +L+   E     QQR      EV+  ++        W    A TD+ Q  LE     L
Sbjct: 1150 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1209

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
                          Q    + E +Q   L+    V   R+Q+   Q+ L++++     + 
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV---REQLRQEQALLEEIERHGEKVE 1266

Query: 559  SKLKASQAEISSLQSVRQWYQQQLAL--AQEARVRLQGEMAHIQVGQMTQAGLLEHLKL- 615
               + ++  I++++     Y+ QL    AQ   V    +   +Q G  +++ + E++ L 
Sbjct: 1267 ECQRFAKQYINAIKD----YELQLVTYKAQLEPVASPAKKPKVQSG--SESVIQEYVDLR 1320

Query: 616  ----ENVSLSQQ----LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
                E  +L+ Q    ++ET  R M+E+ R+A Q +  E +                   
Sbjct: 1321 THYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERE------------------- 1360

Query: 668  EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH--LDLMKQ 725
                 RL E E   E+ +++A++ A  + Q E+    L QR Q+ E +++E   +D  +Q
Sbjct: 1361 -----RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQ 1414

Query: 726  LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR---EDTICLLQNEKIILEAAL 782
                QE LQ   QS +A      E+QA+  + +    SR   E+ I +++ +    E   
Sbjct: 1415 KRSIQEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 783  QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
              A+   + L   A   E    +  E  E+LR ++  +S +    + E A+  K   +  
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528

Query: 843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKR-----LDSELKELRQELMQVHGE--KR 895
             +  +    +E  R  A   ++ + + +  R R     L++  +    EL        ++
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 896  TAEAE--LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
            TA+ E  L   H  VAQ+R+           A++ R+E E  L+  Q    + + +    
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
            E + +Q    Q EA K   E +++ RR G     A ++ +   +  E    +     Q+ 
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708

Query: 1014 LAAKE-----AADAELGQLRAQ-------------GGSSDSSLALHERIQALEAELQAVS 1055
            LAA++      A+ E G+ + Q               ++     L   +  + AE++ + 
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR----LEESNKKLA 1111
             SK   E+E +     + Q LE    +  EL +E    R   ++ KR     EE   +  
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1828

Query: 1112 LELEHEKG-KLTGLG-------QSNAALREHNS-----------------ILETALAKRE 1146
             E E     KL  +G       ++  AL+E  +                  LE   A+ +
Sbjct: 1829 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1888

Query: 1147 AD----LVQLNLQVQAVLQRKE-------EEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
            AD    L QL     + L+R++        + RQ++  + AL+AS EK       L+ ++
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1948

Query: 1196 AAAKVEAGHNRRHFKAASLELS--------EVKKELQAKEHLVQKLQAEADDLQIREGKH 1247
               +  A    R  + A LE +        E ++  +A+E + + L AE +  + R+   
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA- 2007

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER--EIQSLKQ 1305
             +E+ + +A++ EAR     L+++ +++ ++Q    QE    + + ++K     +Q  +Q
Sbjct: 2008 LEEVERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2063

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
            +L  T QQ +  L+ L+   +  +   E A+E     +++    + +V E +  +K   +
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAE 2122

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  Q +   +  A K RKE + EA+                A   +  LR   A   E  
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARR--------------AQAEQAALRQKQAADAEME 2168

Query: 1426 KNLNSCLQ------QLKQEMDSLQRQMEE 1448
            K+     Q      Q++QE+ +L+ Q+EE
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197



 Score =  117 bits (293), Expect = 8e-26
 Identities = 167/735 (22%), Positives = 311/735 (42%), Gaps = 115/735 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE-A 423
            LQ    + Q    ++ GE  + R           +A E +E  +Q  +E  +   Q+E A
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAAR----------RAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 424  LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL------SSEVDTLKQSC 477
              L+ S   + +A  QAQ AA   + +A+ E +  +Q  Q +L       +E++  K+  
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
                R    ++  L      L  +++   + +E+ QRL A+  +  R     +  +  +R
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 538  QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
             QM  L     +++ E   L  + K          + +++ Q++     E   ++  E A
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDK---------DNTQRFLQEEA----EKMKQVAEEAA 2281

Query: 598  HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAF 656
             + V    +A  L  L  E+++  + L E   + +KEK      +Q + EA  L  EA  
Sbjct: 2282 RLSVAAQ-EAARLRQLAEEDLAQQRALAE---KMLKEK------MQAVQEATRLKAEAEL 2331

Query: 657  MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            +Q Q  K + +E  +R  E+ E   +  Q++A+     ++ LE       +R +QLE   
Sbjct: 2332 LQQQ--KELAQEQARRLQEDKE---QMAQQLAEETQGFQRTLEA------ERQRQLE--- 2377

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
                     ++   E L+ R   +   Q   +E   R  +   E   +     L   EK+
Sbjct: 2378 ---------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE---LAIKSGQVEHLQ----- 828
             L   +Q  +  +++ D  A RL E   E     EKL++E   L +KS +++ +Q     
Sbjct: 2429 TL---VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
            QET AL++     K+  LQ++  +E   ++    +QL  +  A  ++L  E +  +Q++ 
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIE---QEKAKLEQLFQDEVAKAQQLREEQQRQQQQM- 2541

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                     E E  RL   + + R+   + E  ++  Q+E  ++E      Q  ++Q   
Sbjct: 2542 ---------EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE------QQRRQQEEL 2586

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQ---------KMRRLGSD-LTSAQKEMKTKHKA 998
            + E N+ L++Q++ L+++ R A+   ++         K    G D L     E + +H  
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF 2646

Query: 999  YENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSH 1056
                  + ++RLQEA  L+A+E       Q  AQG ++   LA  E ++     LQ  S 
Sbjct: 2647 DGLRRKVSAQRLQEAGILSAEEL------QRLAQGHTTVDELARREDVRHY---LQGRSS 2697

Query: 1057 SKTLLEKELQEVIAL 1071
               LL K   E +++
Sbjct: 2698 IAGLLLKATNEKLSV 2712



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 181/955 (18%), Positives = 363/955 (38%), Gaps = 94/955 (9%)

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVE-CSHSSQQRQDSLSSEVDTLK--- 474
            G+L    LE  + L+ + E    L  + TKLQ +   C     Q    L S+V  L    
Sbjct: 371  GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGK 430

Query: 475  --QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
              Q   ++ER +    +M+      + +  +      EQ  R + ++ +   ++ ++ N 
Sbjct: 431  VPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 490

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
               L+  + A  +Q+ QV     TL S  +  + E S+L+    + Q  LA  +E + R+
Sbjct: 491  --RLKAGVAAPATQVAQV-----TLQSVQRRPELEDSTLR----YLQDLLAWVEENQHRV 539

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
             G    + +  + +A L  H  L      ++      R+  ++G+++   +G   D L +
Sbjct: 540  DGAEWGVDLPSV-EAQLGSHRGLHQSI--EEFRAKIERARSDEGQLSPATRGAYRDCLGR 596

Query: 653  EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTLLQRDQQ 711
                + +Q AK +     + RL   E     +         L E++ E+V      R+  
Sbjct: 597  ----LDLQYAKLL--NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 650

Query: 712  LEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE----------- 760
            + A ++ +  LM++L L ++ ++  + + D L       +  +   Q             
Sbjct: 651  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 710

Query: 761  ----AASREDTICLLQNEKIILEA-----ALQAAKSGKEELDRGA--RRLEEGTEETSET 809
                 A  ++     Q    + EA      LQ A   K   DR A   RLE+  ++  + 
Sbjct: 711  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 770

Query: 810  LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
             E+L E      G +  L +   A+ +   +     ++ ++ + A       K   ++  
Sbjct: 771  KEQLNE----YKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV---CDYKQVEVTVH 823

Query: 870  KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
            K    +L    +    +++   G +    +    +     + ++ +  LE   Q+     
Sbjct: 824  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 883

Query: 930  DEMETHLQSL---QFDKEQMVAVTEANEALKKQIE-ELQQEARKAITEQKQKMRRLGSDL 985
             ++   ++SL   Q  +  +  +   + A  + ++ E Q++A  ++    Q   R   D 
Sbjct: 884  HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 943

Query: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
                 E +      E   G  S   Q+ L + E           QG   +S      R Q
Sbjct: 944  GGFGPEDRL---MAEREYGSCSHHYQQLLQSLE-----------QGAQEES------RCQ 983

Query: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105
               +EL+ +      L+ E  E   +    L   +E   E    + E +  + +++ L +
Sbjct: 984  RCISELKDIR-----LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1038

Query: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE--ADLVQLNLQVQAVLQRK 1163
               +L+ E E    K+  L + + A     S LE  L K E    L  + L+    +   
Sbjct: 1039 GVARLSAEAE----KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 1164 EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKEL 1223
                +  + +++A +  L KE + V +   ++ A K      R   +A       ++ EL
Sbjct: 1095 IRGTQGAEEVLRAHEEQL-KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1153

Query: 1224 QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
            +  + + ++LQ    +  +   +  + +AQ         AQ  + Q++L EQL +Q    
Sbjct: 1154 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL-EQLGRQLRYY 1212

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQE 1337
            +E  +      Q  R  Q   Q + L + Q  R++L   Q LL+ ++   E  +E
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 96/471 (20%), Positives = 187/471 (39%), Gaps = 57/471 (12%)

Query: 918  LEGHLQSAQK-----------ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            LEG +Q+ Q            E++  + H+  L+ +K Q+ +  E  E L++ + +LQ E
Sbjct: 346  LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK-QLRSEFERLECLQRIVTKLQME 404

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            A     +  Q    L SD+                A G + +R  E     + AD+ +  
Sbjct: 405  AGLCEEQLNQADALLQSDVRLL-------------AAGKVPQRAGEVERDLDKADSMIRL 451

Query: 1027 L-----RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            L       + G       ++ R+  L   L A+   +T     L+  +A  + ++ +   
Sbjct: 452  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTL 508

Query: 1082 KVLELEDELQES--RGFRKKIKRLEESNKKL--------ALELEHEKGKLTGLGQSNAAL 1131
            + ++   EL++S  R  +  +  +EE+  ++           +E + G   GL QS    
Sbjct: 509  QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF 568

Query: 1132 R---------EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
            R         E      T  A R+  L +L+LQ   +L   +   R ++ L  +  A+  
Sbjct: 569  RAKIERARSDEGQLSPATRGAYRDC-LGRLDLQYAKLLNSSKARLRSLESL-HSFVAAAT 626

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
            KE   +N  +E+      +      +  A     S + +EL+ KE  +++LQ   D L  
Sbjct: 627  KELMWLNEKEEEEVG--FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 684

Query: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
             +      +  FQA L    + +  L   ++  L +     Q   +++    Q ++  ++
Sbjct: 685  EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 744

Query: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLS-MTQKDKFMLQAK 1352
            L+++           LE L Q  Q+ K +L   +  LS + ++ K ++Q K
Sbjct: 745  LRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 795


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  185 bits (469), Expect = 3e-46
 Identities = 228/1070 (21%), Positives = 458/1070 (42%), Gaps = 119/1070 (11%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E   AE +E + +V     +     EA +   +QA +E  ELQ ++     ++  + E +
Sbjct: 1356 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA 1412

Query: 457  HSSQQRQDSLSSEVDTLKQS-----------CWDLERAMTDLQNMLEAKNASLASSNNDL 505
              +QQ++ S+  E+  L+QS               ER+   ++  +      L ++    
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472

Query: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
              AE + Q L A+ E+ +            LR+Q+     + +Q ++E   L S++KA +
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE---LASRVKA-E 1528

Query: 566  AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLT 625
            AE +         ++Q AL     +RLQ E A  ++ Q      +E  +   V+L     
Sbjct: 1529 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQR 1576

Query: 626  ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA---KTMVEEDLQRRLEEFEGERE 682
              +     ++   A +   +E  + ++  A  Q++E    +   + + +R  EE E E E
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636

Query: 683  RLQRMADSAASLEQQLEQV----KLTLLQRDQQLEALQQE-------HLDLMKQLTLTQE 731
            R Q  A+ A  L  Q E+V     L   + ++Q E  ++E           ++Q  L ++
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696

Query: 732  ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
             L+ + Q  +         +  L  L+ E    E    LL+ E   L+    AA   ++E
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756

Query: 792  LDRGARRLE-----------EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            L+    ++               EE+  T EK ++ L  ++G+   L +E A L+   ++
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1816

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRT 896
             K Q  +Q    +A R+ A ++  L  +L    +ATR + ++E+  L+++  +    +R 
Sbjct: 1817 AKRQ--RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA-LKEKEAENERLRRL 1873

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE--------METHLQSLQFDKEQMVA 948
            AE E  +  R   Q  QH AD+E  L   +K  D         +E  L+  +  +E+++A
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933

Query: 949  V----------------------TEANEALK-KQIEELQQEARKAITEQKQKMRRLGSDL 985
            +                      + A + L+ K+  EL+   ++ +  ++++ RR   + 
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993

Query: 986  T----SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG-QLRAQGGSSDSSLAL 1040
                 +A++E   + KA    V  L  +++EA   +E A+ E   QL+    ++   L  
Sbjct: 1994 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053

Query: 1041 HER-----IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095
             E+     +Q  E ELQ     +  +  +L+       +  EE+ E  ++ E E  +SR 
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113

Query: 1096 FRKKIKRLEESNKKLA---LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
              ++ +RL++S ++ A    + +    KL    +  AA R      + AL +++A   ++
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEM 2171

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
                +   Q   ++  Q++  +  L+  LE+   + N L E++   K EA    R     
Sbjct: 2172 EKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2230

Query: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
              EL  V+ +++    L  +++AE   L +R+  ++Q   Q +AE            KQ+
Sbjct: 2231 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK----------MKQV 2280

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
             E+ ++  V  QE   L+   ++   + ++L +++   + Q  +E   L+   + ++ + 
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            E+AQE     Q+DK  +  +++E     +  L+  +Q +L++   A + +
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390



 Score =  180 bits (456), Expect = 1e-44
 Identities = 270/1151 (23%), Positives = 491/1151 (42%), Gaps = 185/1151 (16%)

Query: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
            Q  A   + Q Q+ +   R     + S V  E+ AA  ++  LQ L+E   L  Q E   
Sbjct: 1497 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAE 1553

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
                QA  E+A  Q Q+A  + +  A+ E     Q ++ S + +   L++S  +   A+ 
Sbjct: 1554 RRLRQAEVERAR-QVQVALETAQRSAEAEL----QSKRASFAEKTAQLERSLQEEHVAVA 1608

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD---------- 535
             L+   E +    A +    + AE + +R   K  +  R  L  +               
Sbjct: 1609 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1668

Query: 536  -------------------LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
                               +RQ+  A Q   +Q QL   T   +L A Q E+  L++  +
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETE 1727

Query: 577  WYQQQLALAQEARVRLQGEMAHI-QVGQMTQAGLLE-HLKLENVSLSQQLTETQHRSMKE 634
              +QQ  L +E   RLQ E A   Q  Q  +A L +   ++E +  S+   E + RS  E
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787

Query: 635  KGRIAAQLQGIEADMLDQEAAFMQI--QEAKT---MVEEDLQRR---------------- 673
            K +   + +      L +EAA ++   +EAK    + EED  R+                
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847

Query: 674  ------------LEEFEGERERLQRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQ 717
                        L+E E E ERL+R+A+  A     LE+Q  Q K  + +R  QL     
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907

Query: 718  EHLDLMKQLTLTQEALQSR---EQSLDALQTHYDELQARLGELQGEA----ASREDTICL 770
              L+  +Q  L ++ L+ R   E+ + AL+  +++  A   EL+ E     ++ EDT  L
Sbjct: 1908 SELE--RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT--L 1963

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
               E+  LEAA Q   + +EE     RR  E  E   ++L    E    +   +E +++ 
Sbjct: 1964 RSKEQAELEAARQRQLAAEEE-----RRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2018

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
             A ++ + ++++E+  Q+        ++A  K +L +E KA    +  + +EL+Q L Q 
Sbjct: 2019 KAKVE-EARRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2076

Query: 891  HG--EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                ++   EAE +R   E A+  +  A+ E     A + R ++E   +  Q  +EQ  A
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQA 2131

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR 1008
              +A  A +K  +E +QEA +    ++  +R+      +A  EM+ KHK +         
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QAADAEME-KHKKFA-------- 2178

Query: 1009 RLQEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKEL-- 1065
              ++ L  K   + EL  LR Q   +D     L E +Q L+AE    +  ++ +E+EL  
Sbjct: 2179 --EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236

Query: 1066 -----QEVIALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKG 1119
                 +E+  L ++   E+R  +L  +D  Q   +   +K+K++ E   +L++  + E  
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAA 2295

Query: 1120 KLTGLGQSNAA---------LREH-NSILETALAKREADLVQLNLQVQAVLQRKEEEDR- 1168
            +L  L + + A         L+E   ++ E    K EA+L+Q   ++     R+ +ED+ 
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355

Query: 1169 ----QMKHLVQALQASLEKEKEK-------VNSLKEQVAA---AKVEAGHNRRHFKAASL 1214
                Q+    Q  Q +LE E+++          LK +VA    A+  A  + + F+  + 
Sbjct: 2356 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415

Query: 1215 ELSEV--KKELQAKEHL-------VQKLQAEADDLQIREG-----------KHSQEIAQF 1254
            E+ E   + EL  +E +       +Q+ Q++ D  ++RE            +   ++ Q 
Sbjct: 2416 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2475

Query: 1255 QAELAEARAQLQLLQK----------QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
            ++E  +   Q QLLQ+          + D  L ++    QE   L+     +  + Q L+
Sbjct: 2476 KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR 2535

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
            ++    +QQ  +E + L   ++  +     A+E +   Q++   LQ    + +   + L 
Sbjct: 2536 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQEELLA 2592

Query: 1365 QQNQQLKLDLR 1375
            ++NQ+L+  L+
Sbjct: 2593 EENQRLREQLQ 2603



 Score =  155 bits (392), Expect = 3e-37
 Identities = 253/1169 (21%), Positives = 477/1169 (40%), Gaps = 174/1169 (14%)

Query: 393  SVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQALKEKAELQAQLA-----AL 445
            ++SL     +  EE+L+  +E+++    + A    LEA++A  +K   QA+       AL
Sbjct: 1094 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1153

Query: 446  STKLQAQVECSHSSQQRQDSLSSEVDTLKQSC------WDLERAMTDL-QNMLEAKNASL 498
              +L+   E     QQR      EV+  ++        W    A TD+ Q  LE     L
Sbjct: 1154 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1213

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
                          Q    + E +Q   L+    V   R+Q+   Q+ L++++     + 
Sbjct: 1214 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV---REQLRQEQALLEEIERHGEKVE 1270

Query: 559  SKLKASQAEISSLQSVRQWYQQQLAL--AQEARVRLQGEMAHIQVGQMTQAGLLEHLKL- 615
               + ++  I++++     Y+ QL    AQ   V    +   +Q G  +++ + E++ L 
Sbjct: 1271 ECQRFAKQYINAIKD----YELQLVTYKAQLEPVASPAKKPKVQSG--SESVIQEYVDLR 1324

Query: 616  ----ENVSLSQQ----LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
                E  +L+ Q    ++ET  R M+E+ R+A Q +  E +                   
Sbjct: 1325 THYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERE------------------- 1364

Query: 668  EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH--LDLMKQ 725
                 RL E E   E+ +++A++ A  + Q E+    L QR Q+ E +++E   +D  +Q
Sbjct: 1365 -----RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQ 1418

Query: 726  LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR---EDTICLLQNEKIILEAAL 782
                QE LQ   QS +A      E+QA+  + +    SR   E+ I +++ +    E   
Sbjct: 1419 KRSIQEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472

Query: 783  QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
              A+   + L   A   E    +  E  E+LR ++  +S +    + E A+  K   +  
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532

Query: 843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKR-----LDSELKELRQELMQVHGE--KR 895
             +  +    +E  R  A   ++ + + +  R R     L++  +    EL        ++
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592

Query: 896  TAEAE--LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
            TA+ E  L   H  VAQ+R+           A++ R+E E  L+  Q    + + +    
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652

Query: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
            E + +Q    Q EA K   E +++ RR G     A ++ +   +  E    +     Q+ 
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712

Query: 1014 LAAKE-----AADAELGQLRAQ-------------GGSSDSSLALHERIQALEAELQAVS 1055
            LAA++      A+ E G+ + Q               ++     L   +  + AE++ + 
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR----LEESNKKLA 1111
             SK   E+E +     + Q LE    +  EL +E    R   ++ KR     EE   +  
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1832

Query: 1112 LELEHEKG-KLTGLG-------QSNAALREHNS-----------------ILETALAKRE 1146
             E E     KL  +G       ++  AL+E  +                  LE   A+ +
Sbjct: 1833 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1892

Query: 1147 AD----LVQLNLQVQAVLQRKE-------EEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
            AD    L QL     + L+R++        + RQ++  + AL+AS EK       L+ ++
Sbjct: 1893 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1952

Query: 1196 AAAKVEAGHNRRHFKAASLELS--------EVKKELQAKEHLVQKLQAEADDLQIREGKH 1247
               +  A    R  + A LE +        E ++  +A+E + + L AE +  + R+   
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA- 2011

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER--EIQSLKQ 1305
             +E+ + +A++ EAR     L+++ +++ ++Q    QE    + + ++K     +Q  +Q
Sbjct: 2012 LEEVERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2067

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
            +L  T QQ +  L+ L+   +  +   E A+E     +++    + +V E +  +K   +
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAE 2126

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  Q +   +  A K RKE + EA+                A   +  LR   A   E  
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARR--------------AQAEQAALRQKQAADAEME 2172

Query: 1426 KNLNSCLQ------QLKQEMDSLQRQMEE 1448
            K+     Q      Q++QE+ +L+ Q+EE
Sbjct: 2173 KHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201



 Score =  117 bits (293), Expect = 8e-26
 Identities = 167/735 (22%), Positives = 311/735 (42%), Gaps = 115/735 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE-A 423
            LQ    + Q    ++ GE  + R           +A E +E  +Q  +E  +   Q+E A
Sbjct: 2069 LQQTLQQEQSVLDQLRGEAEAAR----------RAAEEAEEARVQAEREAAQSRRQVEEA 2118

Query: 424  LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL------SSEVDTLKQSC 477
              L+ S   + +A  QAQ AA   + +A+ E +  +Q  Q +L       +E++  K+  
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
                R    ++  L      L  +++   + +E+ QRL A+  +  R     +  +  +R
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238

Query: 538  QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
             QM  L     +++ E   L  + K          + +++ Q++     E   ++  E A
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDK---------DNTQRFLQEEA----EKMKQVAEEAA 2285

Query: 598  HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAF 656
             + V    +A  L  L  E+++  + L E   + +KEK      +Q + EA  L  EA  
Sbjct: 2286 RLSVAAQ-EAARLRQLAEEDLAQQRALAE---KMLKEK------MQAVQEATRLKAEAEL 2335

Query: 657  MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            +Q Q  K + +E  +R  E+ E   +  Q++A+     ++ LE       +R +QLE   
Sbjct: 2336 LQQQ--KELAQEQARRLQEDKE---QMAQQLAEETQGFQRTLEA------ERQRQLE--- 2381

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
                     ++   E L+ R   +   Q   +E   R  +   E   +     L   EK+
Sbjct: 2382 ---------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2432

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE---LAIKSGQVEHLQ----- 828
             L   +Q  +  +++ D  A RL E   E     EKL++E   L +KS +++ +Q     
Sbjct: 2433 TL---VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2489

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
            QET AL++     K+  LQ++  +E   ++    +QL  +  A  ++L  E +  +Q++ 
Sbjct: 2490 QETQALQQSFLSEKDSLLQRERFIE---QEKAKLEQLFQDEVAKAQQLREEQQRQQQQM- 2545

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                     E E  RL   + + R+   + E  ++  Q+E  ++E      Q  ++Q   
Sbjct: 2546 ---------EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE------QQRRQQEEL 2590

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQ---------KMRRLGSD-LTSAQKEMKTKHKA 998
            + E N+ L++Q++ L+++ R A+   ++         K    G D L     E + +H  
Sbjct: 2591 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF 2650

Query: 999  YENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSH 1056
                  + ++RLQEA  L+A+E       Q  AQG ++   LA  E ++     LQ  S 
Sbjct: 2651 DGLRRKVSAQRLQEAGILSAEEL------QRLAQGHTTVDELARREDVRHY---LQGRSS 2701

Query: 1057 SKTLLEKELQEVIAL 1071
               LL K   E +++
Sbjct: 2702 IAGLLLKATNEKLSV 2716



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 181/955 (18%), Positives = 363/955 (38%), Gaps = 94/955 (9%)

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVE-CSHSSQQRQDSLSSEVDTLK--- 474
            G+L    LE  + L+ + E    L  + TKLQ +   C     Q    L S+V  L    
Sbjct: 375  GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGK 434

Query: 475  --QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
              Q   ++ER +    +M+      + +  +      EQ  R + ++ +   ++ ++ N 
Sbjct: 435  VPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 494

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
               L+  + A  +Q+ QV     TL S  +  + E S+L+    + Q  LA  +E + R+
Sbjct: 495  --RLKAGVAAPATQVAQV-----TLQSVQRRPELEDSTLR----YLQDLLAWVEENQHRV 543

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
             G    + +  + +A L  H  L      ++      R+  ++G+++   +G   D L +
Sbjct: 544  DGAEWGVDLPSV-EAQLGSHRGLHQSI--EEFRAKIERARSDEGQLSPATRGAYRDCLGR 600

Query: 653  EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTLLQRDQQ 711
                + +Q AK +     + RL   E     +         L E++ E+V      R+  
Sbjct: 601  ----LDLQYAKLL--NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 654

Query: 712  LEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE----------- 760
            + A ++ +  LM++L L ++ ++  + + D L       +  +   Q             
Sbjct: 655  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 714

Query: 761  ----AASREDTICLLQNEKIILEA-----ALQAAKSGKEELDRGA--RRLEEGTEETSET 809
                 A  ++     Q    + EA      LQ A   K   DR A   RLE+  ++  + 
Sbjct: 715  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 774

Query: 810  LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
             E+L E      G +  L +   A+ +   +     ++ ++ + A       K   ++  
Sbjct: 775  KEQLNE----YKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV---CDYKQVEVTVH 827

Query: 870  KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
            K    +L    +    +++   G +    +    +     + ++ +  LE   Q+     
Sbjct: 828  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 887

Query: 930  DEMETHLQSL---QFDKEQMVAVTEANEALKKQIE-ELQQEARKAITEQKQKMRRLGSDL 985
             ++   ++SL   Q  +  +  +   + A  + ++ E Q++A  ++    Q   R   D 
Sbjct: 888  HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 947

Query: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
                 E +      E   G  S   Q+ L + E           QG   +S      R Q
Sbjct: 948  GGFGPEDRL---MAEREYGSCSHHYQQLLQSLE-----------QGAQEES------RCQ 987

Query: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105
               +EL+ +      L+ E  E   +    L   +E   E    + E +  + +++ L +
Sbjct: 988  RCISELKDIR-----LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1042

Query: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE--ADLVQLNLQVQAVLQRK 1163
               +L+ E E    K+  L + + A     S LE  L K E    L  + L+    +   
Sbjct: 1043 GVARLSAEAE----KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1098

Query: 1164 EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKEL 1223
                +  + +++A +  L KE + V +   ++ A K      R   +A       ++ EL
Sbjct: 1099 IRGTQGAEEVLRAHEEQL-KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1157

Query: 1224 QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
            +  + + ++LQ    +  +   +  + +AQ         AQ  + Q++L EQL +Q    
Sbjct: 1158 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL-EQLGRQLRYY 1216

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQE 1337
            +E  +      Q  R  Q   Q + L + Q  R++L   Q LL+ ++   E  +E
Sbjct: 1217 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 96/471 (20%), Positives = 187/471 (39%), Gaps = 57/471 (12%)

Query: 918  LEGHLQSAQK-----------ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            LEG +Q+ Q            E++  + H+  L+ +K Q+ +  E  E L++ + +LQ E
Sbjct: 350  LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK-QLRSEFERLECLQRIVTKLQME 408

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            A     +  Q    L SD+                A G + +R  E     + AD+ +  
Sbjct: 409  AGLCEEQLNQADALLQSDVRLL-------------AAGKVPQRAGEVERDLDKADSMIRL 455

Query: 1027 L-----RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            L       + G       ++ R+  L   L A+   +T     L+  +A  + ++ +   
Sbjct: 456  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTL 512

Query: 1082 KVLELEDELQES--RGFRKKIKRLEESNKKL--------ALELEHEKGKLTGLGQSNAAL 1131
            + ++   EL++S  R  +  +  +EE+  ++           +E + G   GL QS    
Sbjct: 513  QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF 572

Query: 1132 R---------EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
            R         E      T  A R+  L +L+LQ   +L   +   R ++ L  +  A+  
Sbjct: 573  RAKIERARSDEGQLSPATRGAYRDC-LGRLDLQYAKLLNSSKARLRSLESL-HSFVAAAT 630

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
            KE   +N  +E+      +      +  A     S + +EL+ KE  +++LQ   D L  
Sbjct: 631  KELMWLNEKEEEEVG--FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 688

Query: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
             +      +  FQA L    + +  L   ++  L +     Q   +++    Q ++  ++
Sbjct: 689  EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 748

Query: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLS-MTQKDKFMLQAK 1352
            L+++           LE L Q  Q+ K +L   +  LS + ++ K ++Q K
Sbjct: 749  LRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 799


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  185 bits (469), Expect = 3e-46
 Identities = 228/1070 (21%), Positives = 458/1070 (42%), Gaps = 119/1070 (11%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E   AE +E + +V     +     EA +   +QA +E  ELQ ++     ++  + E +
Sbjct: 1352 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA 1408

Query: 457  HSSQQRQDSLSSEVDTLKQS-----------CWDLERAMTDLQNMLEAKNASLASSNNDL 505
              +QQ++ S+  E+  L+QS               ER+   ++  +      L ++    
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
              AE + Q L A+ E+ +            LR+Q+     + +Q ++E   L S++KA +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE---LASRVKA-E 1524

Query: 566  AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLT 625
            AE +         ++Q AL     +RLQ E A  ++ Q      +E  +   V+L     
Sbjct: 1525 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQR 1572

Query: 626  ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA---KTMVEEDLQRRLEEFEGERE 682
              +     ++   A +   +E  + ++  A  Q++E    +   + + +R  EE E E E
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 683  RLQRMADSAASLEQQLEQV----KLTLLQRDQQLEALQQE-------HLDLMKQLTLTQE 731
            R Q  A+ A  L  Q E+V     L   + ++Q E  ++E           ++Q  L ++
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 732  ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
             L+ + Q  +         +  L  L+ E    E    LL+ E   L+    AA   ++E
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 792  LDRGARRLE-----------EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            L+    ++               EE+  T EK ++ L  ++G+   L +E A L+   ++
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRT 896
             K Q  +Q    +A R+ A ++  L  +L    +ATR + ++E+  L+++  +    +R 
Sbjct: 1813 AKRQ--RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA-LKEKEAENERLRRL 1869

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE--------METHLQSLQFDKEQMVA 948
            AE E  +  R   Q  QH AD+E  L   +K  D         +E  L+  +  +E+++A
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929

Query: 949  V----------------------TEANEALK-KQIEELQQEARKAITEQKQKMRRLGSDL 985
            +                      + A + L+ K+  EL+   ++ +  ++++ RR   + 
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989

Query: 986  T----SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG-QLRAQGGSSDSSLAL 1040
                 +A++E   + KA    V  L  +++EA   +E A+ E   QL+    ++   L  
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049

Query: 1041 HER-----IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095
             E+     +Q  E ELQ     +  +  +L+       +  EE+ E  ++ E E  +SR 
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109

Query: 1096 FRKKIKRLEESNKKLA---LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
              ++ +RL++S ++ A    + +    KL    +  AA R      + AL +++A   ++
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEM 2167

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
                +   Q   ++  Q++  +  L+  LE+   + N L E++   K EA    R     
Sbjct: 2168 EKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226

Query: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
              EL  V+ +++    L  +++AE   L +R+  ++Q   Q +AE            KQ+
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK----------MKQV 2276

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
             E+ ++  V  QE   L+   ++   + ++L +++   + Q  +E   L+   + ++ + 
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            E+AQE     Q+DK  +  +++E     +  L+  +Q +L++   A + +
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386



 Score =  180 bits (456), Expect = 1e-44
 Identities = 270/1151 (23%), Positives = 491/1151 (42%), Gaps = 185/1151 (16%)

Query: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
            Q  A   + Q Q+ +   R     + S V  E+ AA  ++  LQ L+E   L  Q E   
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAE 1549

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
                QA  E+A  Q Q+A  + +  A+ E     Q ++ S + +   L++S  +   A+ 
Sbjct: 1550 RRLRQAEVERAR-QVQVALETAQRSAEAEL----QSKRASFAEKTAQLERSLQEEHVAVA 1604

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD---------- 535
             L+   E +    A +    + AE + +R   K  +  R  L  +               
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 536  -------------------LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
                               +RQ+  A Q   +Q QL   T   +L A Q E+  L++  +
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETE 1723

Query: 577  WYQQQLALAQEARVRLQGEMAHI-QVGQMTQAGLLE-HLKLENVSLSQQLTETQHRSMKE 634
              +QQ  L +E   RLQ E A   Q  Q  +A L +   ++E +  S+   E + RS  E
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783

Query: 635  KGRIAAQLQGIEADMLDQEAAFMQI--QEAKT---MVEEDLQRR---------------- 673
            K +   + +      L +EAA ++   +EAK    + EED  R+                
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843

Query: 674  ------------LEEFEGERERLQRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQ 717
                        L+E E E ERL+R+A+  A     LE+Q  Q K  + +R  QL     
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 718  EHLDLMKQLTLTQEALQSR---EQSLDALQTHYDELQARLGELQGEA----ASREDTICL 770
              L+  +Q  L ++ L+ R   E+ + AL+  +++  A   EL+ E     ++ EDT  L
Sbjct: 1904 SELE--RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT--L 1959

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
               E+  LEAA Q   + +EE     RR  E  E   ++L    E    +   +E +++ 
Sbjct: 1960 RSKEQAELEAARQRQLAAEEE-----RRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
             A ++ + ++++E+  Q+        ++A  K +L +E KA    +  + +EL+Q L Q 
Sbjct: 2015 KAKVE-EARRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2072

Query: 891  HG--EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                ++   EAE +R   E A+  +  A+ E     A + R ++E   +  Q  +EQ  A
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR 1008
              +A  A +K  +E +QEA +    ++  +R+      +A  EM+ KHK +         
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QAADAEME-KHKKFA-------- 2174

Query: 1009 RLQEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKEL-- 1065
              ++ L  K   + EL  LR Q   +D     L E +Q L+AE    +  ++ +E+EL  
Sbjct: 2175 --EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232

Query: 1066 -----QEVIALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKG 1119
                 +E+  L ++   E+R  +L  +D  Q   +   +K+K++ E   +L++  + E  
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAA 2291

Query: 1120 KLTGLGQSNAA---------LREH-NSILETALAKREADLVQLNLQVQAVLQRKEEEDR- 1168
            +L  L + + A         L+E   ++ E    K EA+L+Q   ++     R+ +ED+ 
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351

Query: 1169 ----QMKHLVQALQASLEKEKEK-------VNSLKEQVAA---AKVEAGHNRRHFKAASL 1214
                Q+    Q  Q +LE E+++          LK +VA    A+  A  + + F+  + 
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 1215 ELSEV--KKELQAKEHL-------VQKLQAEADDLQIREG-----------KHSQEIAQF 1254
            E+ E   + EL  +E +       +Q+ Q++ D  ++RE            +   ++ Q 
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2471

Query: 1255 QAELAEARAQLQLLQK----------QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
            ++E  +   Q QLLQ+          + D  L ++    QE   L+     +  + Q L+
Sbjct: 2472 KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR 2531

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
            ++    +QQ  +E + L   ++  +     A+E +   Q++   LQ    + +   + L 
Sbjct: 2532 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQEELLA 2588

Query: 1365 QQNQQLKLDLR 1375
            ++NQ+L+  L+
Sbjct: 2589 EENQRLREQLQ 2599



 Score =  155 bits (392), Expect = 3e-37
 Identities = 253/1169 (21%), Positives = 477/1169 (40%), Gaps = 174/1169 (14%)

Query: 393  SVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQALKEKAELQAQLA-----AL 445
            ++SL     +  EE+L+  +E+++    + A    LEA++A  +K   QA+       AL
Sbjct: 1090 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1149

Query: 446  STKLQAQVECSHSSQQRQDSLSSEVDTLKQSC------WDLERAMTDL-QNMLEAKNASL 498
              +L+   E     QQR      EV+  ++        W    A TD+ Q  LE     L
Sbjct: 1150 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1209

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
                          Q    + E +Q   L+    V   R+Q+   Q+ L++++     + 
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV---REQLRQEQALLEEIERHGEKVE 1266

Query: 559  SKLKASQAEISSLQSVRQWYQQQLAL--AQEARVRLQGEMAHIQVGQMTQAGLLEHLKL- 615
               + ++  I++++     Y+ QL    AQ   V    +   +Q G  +++ + E++ L 
Sbjct: 1267 ECQRFAKQYINAIKD----YELQLVTYKAQLEPVASPAKKPKVQSG--SESVIQEYVDLR 1320

Query: 616  ----ENVSLSQQ----LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
                E  +L+ Q    ++ET  R M+E+ R+A Q +  E +                   
Sbjct: 1321 THYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERE------------------- 1360

Query: 668  EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH--LDLMKQ 725
                 RL E E   E+ +++A++ A  + Q E+    L QR Q+ E +++E   +D  +Q
Sbjct: 1361 -----RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQ 1414

Query: 726  LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR---EDTICLLQNEKIILEAAL 782
                QE LQ   QS +A      E+QA+  + +    SR   E+ I +++ +    E   
Sbjct: 1415 KRSIQEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 783  QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
              A+   + L   A   E    +  E  E+LR ++  +S +    + E A+  K   +  
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528

Query: 843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKR-----LDSELKELRQELMQVHGE--KR 895
             +  +    +E  R  A   ++ + + +  R R     L++  +    EL        ++
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 896  TAEAE--LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
            TA+ E  L   H  VAQ+R+           A++ R+E E  L+  Q    + + +    
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
            E + +Q    Q EA K   E +++ RR G     A ++ +   +  E    +     Q+ 
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708

Query: 1014 LAAKE-----AADAELGQLRAQ-------------GGSSDSSLALHERIQALEAELQAVS 1055
            LAA++      A+ E G+ + Q               ++     L   +  + AE++ + 
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR----LEESNKKLA 1111
             SK   E+E +     + Q LE    +  EL +E    R   ++ KR     EE   +  
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1828

Query: 1112 LELEHEKG-KLTGLG-------QSNAALREHNS-----------------ILETALAKRE 1146
             E E     KL  +G       ++  AL+E  +                  LE   A+ +
Sbjct: 1829 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1888

Query: 1147 AD----LVQLNLQVQAVLQRKE-------EEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
            AD    L QL     + L+R++        + RQ++  + AL+AS EK       L+ ++
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1948

Query: 1196 AAAKVEAGHNRRHFKAASLELS--------EVKKELQAKEHLVQKLQAEADDLQIREGKH 1247
               +  A    R  + A LE +        E ++  +A+E + + L AE +  + R+   
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA- 2007

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER--EIQSLKQ 1305
             +E+ + +A++ EAR     L+++ +++ ++Q    QE    + + ++K     +Q  +Q
Sbjct: 2008 LEEVERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2063

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
            +L  T QQ +  L+ L+   +  +   E A+E     +++    + +V E +  +K   +
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAE 2122

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  Q +   +  A K RKE + EA+                A   +  LR   A   E  
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARR--------------AQAEQAALRQKQAADAEME 2168

Query: 1426 KNLNSCLQ------QLKQEMDSLQRQMEE 1448
            K+     Q      Q++QE+ +L+ Q+EE
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197



 Score =  117 bits (293), Expect = 8e-26
 Identities = 167/735 (22%), Positives = 311/735 (42%), Gaps = 115/735 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE-A 423
            LQ    + Q    ++ GE  + R           +A E +E  +Q  +E  +   Q+E A
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAAR----------RAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 424  LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL------SSEVDTLKQSC 477
              L+ S   + +A  QAQ AA   + +A+ E +  +Q  Q +L       +E++  K+  
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
                R    ++  L      L  +++   + +E+ QRL A+  +  R     +  +  +R
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 538  QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
             QM  L     +++ E   L  + K          + +++ Q++     E   ++  E A
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDK---------DNTQRFLQEEA----EKMKQVAEEAA 2281

Query: 598  HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAF 656
             + V    +A  L  L  E+++  + L E   + +KEK      +Q + EA  L  EA  
Sbjct: 2282 RLSVAAQ-EAARLRQLAEEDLAQQRALAE---KMLKEK------MQAVQEATRLKAEAEL 2331

Query: 657  MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            +Q Q  K + +E  +R  E+ E   +  Q++A+     ++ LE       +R +QLE   
Sbjct: 2332 LQQQ--KELAQEQARRLQEDKE---QMAQQLAEETQGFQRTLEA------ERQRQLE--- 2377

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
                     ++   E L+ R   +   Q   +E   R  +   E   +     L   EK+
Sbjct: 2378 ---------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE---LAIKSGQVEHLQ----- 828
             L   +Q  +  +++ D  A RL E   E     EKL++E   L +KS +++ +Q     
Sbjct: 2429 TL---VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
            QET AL++     K+  LQ++  +E   ++    +QL  +  A  ++L  E +  +Q++ 
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIE---QEKAKLEQLFQDEVAKAQQLREEQQRQQQQM- 2541

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                     E E  RL   + + R+   + E  ++  Q+E  ++E      Q  ++Q   
Sbjct: 2542 ---------EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE------QQRRQQEEL 2586

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQ---------KMRRLGSD-LTSAQKEMKTKHKA 998
            + E N+ L++Q++ L+++ R A+   ++         K    G D L     E + +H  
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF 2646

Query: 999  YENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSH 1056
                  + ++RLQEA  L+A+E       Q  AQG ++   LA  E ++     LQ  S 
Sbjct: 2647 DGLRRKVSAQRLQEAGILSAEEL------QRLAQGHTTVDELARREDVRHY---LQGRSS 2697

Query: 1057 SKTLLEKELQEVIAL 1071
               LL K   E +++
Sbjct: 2698 IAGLLLKATNEKLSV 2712



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 181/955 (18%), Positives = 363/955 (38%), Gaps = 94/955 (9%)

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVE-CSHSSQQRQDSLSSEVDTLK--- 474
            G+L    LE  + L+ + E    L  + TKLQ +   C     Q    L S+V  L    
Sbjct: 371  GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGK 430

Query: 475  --QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
              Q   ++ER +    +M+      + +  +      EQ  R + ++ +   ++ ++ N 
Sbjct: 431  VPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 490

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
               L+  + A  +Q+ QV     TL S  +  + E S+L+    + Q  LA  +E + R+
Sbjct: 491  --RLKAGVAAPATQVAQV-----TLQSVQRRPELEDSTLR----YLQDLLAWVEENQHRV 539

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
             G    + +  + +A L  H  L      ++      R+  ++G+++   +G   D L +
Sbjct: 540  DGAEWGVDLPSV-EAQLGSHRGLHQSI--EEFRAKIERARSDEGQLSPATRGAYRDCLGR 596

Query: 653  EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTLLQRDQQ 711
                + +Q AK +     + RL   E     +         L E++ E+V      R+  
Sbjct: 597  ----LDLQYAKLL--NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 650

Query: 712  LEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE----------- 760
            + A ++ +  LM++L L ++ ++  + + D L       +  +   Q             
Sbjct: 651  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 710

Query: 761  ----AASREDTICLLQNEKIILEA-----ALQAAKSGKEELDRGA--RRLEEGTEETSET 809
                 A  ++     Q    + EA      LQ A   K   DR A   RLE+  ++  + 
Sbjct: 711  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 770

Query: 810  LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
             E+L E      G +  L +   A+ +   +     ++ ++ + A       K   ++  
Sbjct: 771  KEQLNE----YKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV---CDYKQVEVTVH 823

Query: 870  KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
            K    +L    +    +++   G +    +    +     + ++ +  LE   Q+     
Sbjct: 824  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 883

Query: 930  DEMETHLQSL---QFDKEQMVAVTEANEALKKQIE-ELQQEARKAITEQKQKMRRLGSDL 985
             ++   ++SL   Q  +  +  +   + A  + ++ E Q++A  ++    Q   R   D 
Sbjct: 884  HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 943

Query: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
                 E +      E   G  S   Q+ L + E           QG   +S      R Q
Sbjct: 944  GGFGPEDRL---MAEREYGSCSHHYQQLLQSLE-----------QGAQEES------RCQ 983

Query: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105
               +EL+ +      L+ E  E   +    L   +E   E    + E +  + +++ L +
Sbjct: 984  RCISELKDIR-----LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1038

Query: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE--ADLVQLNLQVQAVLQRK 1163
               +L+ E E    K+  L + + A     S LE  L K E    L  + L+    +   
Sbjct: 1039 GVARLSAEAE----KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 1164 EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKEL 1223
                +  + +++A +  L KE + V +   ++ A K      R   +A       ++ EL
Sbjct: 1095 IRGTQGAEEVLRAHEEQL-KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1153

Query: 1224 QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
            +  + + ++LQ    +  +   +  + +AQ         AQ  + Q++L EQL +Q    
Sbjct: 1154 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL-EQLGRQLRYY 1212

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQE 1337
            +E  +      Q  R  Q   Q + L + Q  R++L   Q LL+ ++   E  +E
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 96/471 (20%), Positives = 187/471 (39%), Gaps = 57/471 (12%)

Query: 918  LEGHLQSAQK-----------ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            LEG +Q+ Q            E++  + H+  L+ +K Q+ +  E  E L++ + +LQ E
Sbjct: 346  LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK-QLRSEFERLECLQRIVTKLQME 404

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            A     +  Q    L SD+                A G + +R  E     + AD+ +  
Sbjct: 405  AGLCEEQLNQADALLQSDVRLL-------------AAGKVPQRAGEVERDLDKADSMIRL 451

Query: 1027 L-----RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            L       + G       ++ R+  L   L A+   +T     L+  +A  + ++ +   
Sbjct: 452  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTL 508

Query: 1082 KVLELEDELQES--RGFRKKIKRLEESNKKL--------ALELEHEKGKLTGLGQSNAAL 1131
            + ++   EL++S  R  +  +  +EE+  ++           +E + G   GL QS    
Sbjct: 509  QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF 568

Query: 1132 R---------EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
            R         E      T  A R+  L +L+LQ   +L   +   R ++ L  +  A+  
Sbjct: 569  RAKIERARSDEGQLSPATRGAYRDC-LGRLDLQYAKLLNSSKARLRSLESL-HSFVAAAT 626

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
            KE   +N  +E+      +      +  A     S + +EL+ KE  +++LQ   D L  
Sbjct: 627  KELMWLNEKEEEEVG--FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 684

Query: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
             +      +  FQA L    + +  L   ++  L +     Q   +++    Q ++  ++
Sbjct: 685  EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 744

Query: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLS-MTQKDKFMLQAK 1352
            L+++           LE L Q  Q+ K +L   +  LS + ++ K ++Q K
Sbjct: 745  LRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 795


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  185 bits (469), Expect = 3e-46
 Identities = 228/1070 (21%), Positives = 458/1070 (42%), Gaps = 119/1070 (11%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E   AE +E + +V     +     EA +   +QA +E  ELQ ++     ++  + E +
Sbjct: 1320 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA 1376

Query: 457  HSSQQRQDSLSSEVDTLKQS-----------CWDLERAMTDLQNMLEAKNASLASSNNDL 505
              +QQ++ S+  E+  L+QS               ER+   ++  +      L ++    
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436

Query: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
              AE + Q L A+ E+ +            LR+Q+     + +Q ++E   L S++KA +
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE---LASRVKA-E 1492

Query: 566  AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLT 625
            AE +         ++Q AL     +RLQ E A  ++ Q      +E  +   V+L     
Sbjct: 1493 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQR 1540

Query: 626  ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA---KTMVEEDLQRRLEEFEGERE 682
              +     ++   A +   +E  + ++  A  Q++E    +   + + +R  EE E E E
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600

Query: 683  RLQRMADSAASLEQQLEQV----KLTLLQRDQQLEALQQE-------HLDLMKQLTLTQE 731
            R Q  A+ A  L  Q E+V     L   + ++Q E  ++E           ++Q  L ++
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660

Query: 732  ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
             L+ + Q  +         +  L  L+ E    E    LL+ E   L+    AA   ++E
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720

Query: 792  LDRGARRLE-----------EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            L+    ++               EE+  T EK ++ L  ++G+   L +E A L+   ++
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1780

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRT 896
             K Q  +Q    +A R+ A ++  L  +L    +ATR + ++E+  L+++  +    +R 
Sbjct: 1781 AKRQ--RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA-LKEKEAENERLRRL 1837

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE--------METHLQSLQFDKEQMVA 948
            AE E  +  R   Q  QH AD+E  L   +K  D         +E  L+  +  +E+++A
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1897

Query: 949  V----------------------TEANEALK-KQIEELQQEARKAITEQKQKMRRLGSDL 985
            +                      + A + L+ K+  EL+   ++ +  ++++ RR   + 
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957

Query: 986  T----SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG-QLRAQGGSSDSSLAL 1040
                 +A++E   + KA    V  L  +++EA   +E A+ E   QL+    ++   L  
Sbjct: 1958 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2017

Query: 1041 HER-----IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095
             E+     +Q  E ELQ     +  +  +L+       +  EE+ E  ++ E E  +SR 
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2077

Query: 1096 FRKKIKRLEESNKKLA---LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
              ++ +RL++S ++ A    + +    KL    +  AA R      + AL +++A   ++
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEM 2135

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
                +   Q   ++  Q++  +  L+  LE+   + N L E++   K EA    R     
Sbjct: 2136 EKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2194

Query: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
              EL  V+ +++    L  +++AE   L +R+  ++Q   Q +AE            KQ+
Sbjct: 2195 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK----------MKQV 2244

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
             E+ ++  V  QE   L+   ++   + ++L +++   + Q  +E   L+   + ++ + 
Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            E+AQE     Q+DK  +  +++E     +  L+  +Q +L++   A + +
Sbjct: 2305 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354



 Score =  180 bits (456), Expect = 1e-44
 Identities = 270/1151 (23%), Positives = 491/1151 (42%), Gaps = 185/1151 (16%)

Query: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
            Q  A   + Q Q+ +   R     + S V  E+ AA  ++  LQ L+E   L  Q E   
Sbjct: 1461 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAE 1517

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
                QA  E+A  Q Q+A  + +  A+ E     Q ++ S + +   L++S  +   A+ 
Sbjct: 1518 RRLRQAEVERAR-QVQVALETAQRSAEAEL----QSKRASFAEKTAQLERSLQEEHVAVA 1572

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD---------- 535
             L+   E +    A +    + AE + +R   K  +  R  L  +               
Sbjct: 1573 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1632

Query: 536  -------------------LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
                               +RQ+  A Q   +Q QL   T   +L A Q E+  L++  +
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETE 1691

Query: 577  WYQQQLALAQEARVRLQGEMAHI-QVGQMTQAGLLE-HLKLENVSLSQQLTETQHRSMKE 634
              +QQ  L +E   RLQ E A   Q  Q  +A L +   ++E +  S+   E + RS  E
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751

Query: 635  KGRIAAQLQGIEADMLDQEAAFMQI--QEAKT---MVEEDLQRR---------------- 673
            K +   + +      L +EAA ++   +EAK    + EED  R+                
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811

Query: 674  ------------LEEFEGERERLQRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQ 717
                        L+E E E ERL+R+A+  A     LE+Q  Q K  + +R  QL     
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871

Query: 718  EHLDLMKQLTLTQEALQSR---EQSLDALQTHYDELQARLGELQGEA----ASREDTICL 770
              L+  +Q  L ++ L+ R   E+ + AL+  +++  A   EL+ E     ++ EDT  L
Sbjct: 1872 SELE--RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT--L 1927

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
               E+  LEAA Q   + +EE     RR  E  E   ++L    E    +   +E +++ 
Sbjct: 1928 RSKEQAELEAARQRQLAAEEE-----RRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1982

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
             A ++ + ++++E+  Q+        ++A  K +L +E KA    +  + +EL+Q L Q 
Sbjct: 1983 KAKVE-EARRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2040

Query: 891  HG--EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                ++   EAE +R   E A+  +  A+ E     A + R ++E   +  Q  +EQ  A
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQA 2095

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR 1008
              +A  A +K  +E +QEA +    ++  +R+      +A  EM+ KHK +         
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QAADAEME-KHKKFA-------- 2142

Query: 1009 RLQEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKEL-- 1065
              ++ L  K   + EL  LR Q   +D     L E +Q L+AE    +  ++ +E+EL  
Sbjct: 2143 --EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200

Query: 1066 -----QEVIALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKG 1119
                 +E+  L ++   E+R  +L  +D  Q   +   +K+K++ E   +L++  + E  
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAA 2259

Query: 1120 KLTGLGQSNAA---------LREH-NSILETALAKREADLVQLNLQVQAVLQRKEEEDR- 1168
            +L  L + + A         L+E   ++ E    K EA+L+Q   ++     R+ +ED+ 
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319

Query: 1169 ----QMKHLVQALQASLEKEKEK-------VNSLKEQVAA---AKVEAGHNRRHFKAASL 1214
                Q+    Q  Q +LE E+++          LK +VA    A+  A  + + F+  + 
Sbjct: 2320 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379

Query: 1215 ELSEV--KKELQAKEHL-------VQKLQAEADDLQIREG-----------KHSQEIAQF 1254
            E+ E   + EL  +E +       +Q+ Q++ D  ++RE            +   ++ Q 
Sbjct: 2380 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2439

Query: 1255 QAELAEARAQLQLLQK----------QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
            ++E  +   Q QLLQ+          + D  L ++    QE   L+     +  + Q L+
Sbjct: 2440 KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR 2499

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
            ++    +QQ  +E + L   ++  +     A+E +   Q++   LQ    + +   + L 
Sbjct: 2500 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQEELLA 2556

Query: 1365 QQNQQLKLDLR 1375
            ++NQ+L+  L+
Sbjct: 2557 EENQRLREQLQ 2567



 Score =  155 bits (392), Expect = 3e-37
 Identities = 253/1169 (21%), Positives = 477/1169 (40%), Gaps = 174/1169 (14%)

Query: 393  SVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQALKEKAELQAQLA-----AL 445
            ++SL     +  EE+L+  +E+++    + A    LEA++A  +K   QA+       AL
Sbjct: 1058 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1117

Query: 446  STKLQAQVECSHSSQQRQDSLSSEVDTLKQSC------WDLERAMTDL-QNMLEAKNASL 498
              +L+   E     QQR      EV+  ++        W    A TD+ Q  LE     L
Sbjct: 1118 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1177

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
                          Q    + E +Q   L+    V   R+Q+   Q+ L++++     + 
Sbjct: 1178 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV---REQLRQEQALLEEIERHGEKVE 1234

Query: 559  SKLKASQAEISSLQSVRQWYQQQLAL--AQEARVRLQGEMAHIQVGQMTQAGLLEHLKL- 615
               + ++  I++++     Y+ QL    AQ   V    +   +Q G  +++ + E++ L 
Sbjct: 1235 ECQRFAKQYINAIKD----YELQLVTYKAQLEPVASPAKKPKVQSG--SESVIQEYVDLR 1288

Query: 616  ----ENVSLSQQ----LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
                E  +L+ Q    ++ET  R M+E+ R+A Q +  E +                   
Sbjct: 1289 THYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERE------------------- 1328

Query: 668  EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH--LDLMKQ 725
                 RL E E   E+ +++A++ A  + Q E+    L QR Q+ E +++E   +D  +Q
Sbjct: 1329 -----RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQ 1382

Query: 726  LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR---EDTICLLQNEKIILEAAL 782
                QE LQ   QS +A      E+QA+  + +    SR   E+ I +++ +    E   
Sbjct: 1383 KRSIQEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436

Query: 783  QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
              A+   + L   A   E    +  E  E+LR ++  +S +    + E A+  K   +  
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496

Query: 843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKR-----LDSELKELRQELMQVHGE--KR 895
             +  +    +E  R  A   ++ + + +  R R     L++  +    EL        ++
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556

Query: 896  TAEAE--LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
            TA+ E  L   H  VAQ+R+           A++ R+E E  L+  Q    + + +    
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616

Query: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
            E + +Q    Q EA K   E +++ RR G     A ++ +   +  E    +     Q+ 
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676

Query: 1014 LAAKE-----AADAELGQLRAQ-------------GGSSDSSLALHERIQALEAELQAVS 1055
            LAA++      A+ E G+ + Q               ++     L   +  + AE++ + 
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR----LEESNKKLA 1111
             SK   E+E +     + Q LE    +  EL +E    R   ++ KR     EE   +  
Sbjct: 1737 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1796

Query: 1112 LELEHEKG-KLTGLG-------QSNAALREHNS-----------------ILETALAKRE 1146
             E E     KL  +G       ++  AL+E  +                  LE   A+ +
Sbjct: 1797 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1856

Query: 1147 AD----LVQLNLQVQAVLQRKE-------EEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
            AD    L QL     + L+R++        + RQ++  + AL+AS EK       L+ ++
Sbjct: 1857 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1916

Query: 1196 AAAKVEAGHNRRHFKAASLELS--------EVKKELQAKEHLVQKLQAEADDLQIREGKH 1247
               +  A    R  + A LE +        E ++  +A+E + + L AE +  + R+   
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA- 1975

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER--EIQSLKQ 1305
             +E+ + +A++ EAR     L+++ +++ ++Q    QE    + + ++K     +Q  +Q
Sbjct: 1976 LEEVERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2031

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
            +L  T QQ +  L+ L+   +  +   E A+E     +++    + +V E +  +K   +
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAE 2090

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  Q +   +  A K RKE + EA+                A   +  LR   A   E  
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARR--------------AQAEQAALRQKQAADAEME 2136

Query: 1426 KNLNSCLQ------QLKQEMDSLQRQMEE 1448
            K+     Q      Q++QE+ +L+ Q+EE
Sbjct: 2137 KHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165



 Score =  117 bits (293), Expect = 8e-26
 Identities = 167/735 (22%), Positives = 311/735 (42%), Gaps = 115/735 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE-A 423
            LQ    + Q    ++ GE  + R           +A E +E  +Q  +E  +   Q+E A
Sbjct: 2033 LQQTLQQEQSVLDQLRGEAEAAR----------RAAEEAEEARVQAEREAAQSRRQVEEA 2082

Query: 424  LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL------SSEVDTLKQSC 477
              L+ S   + +A  QAQ AA   + +A+ E +  +Q  Q +L       +E++  K+  
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
                R    ++  L      L  +++   + +E+ QRL A+  +  R     +  +  +R
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202

Query: 538  QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
             QM  L     +++ E   L  + K          + +++ Q++     E   ++  E A
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDK---------DNTQRFLQEEA----EKMKQVAEEAA 2249

Query: 598  HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAF 656
             + V    +A  L  L  E+++  + L E   + +KEK      +Q + EA  L  EA  
Sbjct: 2250 RLSVAAQ-EAARLRQLAEEDLAQQRALAE---KMLKEK------MQAVQEATRLKAEAEL 2299

Query: 657  MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            +Q Q  K + +E  +R  E+ E   +  Q++A+     ++ LE       +R +QLE   
Sbjct: 2300 LQQQ--KELAQEQARRLQEDKE---QMAQQLAEETQGFQRTLEA------ERQRQLE--- 2345

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
                     ++   E L+ R   +   Q   +E   R  +   E   +     L   EK+
Sbjct: 2346 ---------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2396

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE---LAIKSGQVEHLQ----- 828
             L   +Q  +  +++ D  A RL E   E     EKL++E   L +KS +++ +Q     
Sbjct: 2397 TL---VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2453

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
            QET AL++     K+  LQ++  +E   ++    +QL  +  A  ++L  E +  +Q++ 
Sbjct: 2454 QETQALQQSFLSEKDSLLQRERFIE---QEKAKLEQLFQDEVAKAQQLREEQQRQQQQM- 2509

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                     E E  RL   + + R+   + E  ++  Q+E  ++E      Q  ++Q   
Sbjct: 2510 ---------EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE------QQRRQQEEL 2554

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQ---------KMRRLGSD-LTSAQKEMKTKHKA 998
            + E N+ L++Q++ L+++ R A+   ++         K    G D L     E + +H  
Sbjct: 2555 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF 2614

Query: 999  YENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSH 1056
                  + ++RLQEA  L+A+E       Q  AQG ++   LA  E ++     LQ  S 
Sbjct: 2615 DGLRRKVSAQRLQEAGILSAEEL------QRLAQGHTTVDELARREDVRHY---LQGRSS 2665

Query: 1057 SKTLLEKELQEVIAL 1071
               LL K   E +++
Sbjct: 2666 IAGLLLKATNEKLSV 2680



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 181/955 (18%), Positives = 363/955 (38%), Gaps = 94/955 (9%)

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVE-CSHSSQQRQDSLSSEVDTLK--- 474
            G+L    LE  + L+ + E    L  + TKLQ +   C     Q    L S+V  L    
Sbjct: 339  GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGK 398

Query: 475  --QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
              Q   ++ER +    +M+      + +  +      EQ  R + ++ +   ++ ++ N 
Sbjct: 399  VPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 458

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
               L+  + A  +Q+ QV     TL S  +  + E S+L+    + Q  LA  +E + R+
Sbjct: 459  --RLKAGVAAPATQVAQV-----TLQSVQRRPELEDSTLR----YLQDLLAWVEENQHRV 507

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
             G    + +  + +A L  H  L      ++      R+  ++G+++   +G   D L +
Sbjct: 508  DGAEWGVDLPSV-EAQLGSHRGLHQSI--EEFRAKIERARSDEGQLSPATRGAYRDCLGR 564

Query: 653  EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTLLQRDQQ 711
                + +Q AK +     + RL   E     +         L E++ E+V      R+  
Sbjct: 565  ----LDLQYAKLL--NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 618

Query: 712  LEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE----------- 760
            + A ++ +  LM++L L ++ ++  + + D L       +  +   Q             
Sbjct: 619  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 678

Query: 761  ----AASREDTICLLQNEKIILEA-----ALQAAKSGKEELDRGA--RRLEEGTEETSET 809
                 A  ++     Q    + EA      LQ A   K   DR A   RLE+  ++  + 
Sbjct: 679  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 738

Query: 810  LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
             E+L E      G +  L +   A+ +   +     ++ ++ + A       K   ++  
Sbjct: 739  KEQLNE----YKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV---CDYKQVEVTVH 791

Query: 870  KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
            K    +L    +    +++   G +    +    +     + ++ +  LE   Q+     
Sbjct: 792  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 851

Query: 930  DEMETHLQSL---QFDKEQMVAVTEANEALKKQIE-ELQQEARKAITEQKQKMRRLGSDL 985
             ++   ++SL   Q  +  +  +   + A  + ++ E Q++A  ++    Q   R   D 
Sbjct: 852  HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 911

Query: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
                 E +      E   G  S   Q+ L + E           QG   +S      R Q
Sbjct: 912  GGFGPEDRL---MAEREYGSCSHHYQQLLQSLE-----------QGAQEES------RCQ 951

Query: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105
               +EL+ +      L+ E  E   +    L   +E   E    + E +  + +++ L +
Sbjct: 952  RCISELKDIR-----LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1006

Query: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE--ADLVQLNLQVQAVLQRK 1163
               +L+ E E    K+  L + + A     S LE  L K E    L  + L+    +   
Sbjct: 1007 GVARLSAEAE----KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1062

Query: 1164 EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKEL 1223
                +  + +++A +  L KE + V +   ++ A K      R   +A       ++ EL
Sbjct: 1063 IRGTQGAEEVLRAHEEQL-KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1121

Query: 1224 QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
            +  + + ++LQ    +  +   +  + +AQ         AQ  + Q++L EQL +Q    
Sbjct: 1122 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL-EQLGRQLRYY 1180

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQE 1337
            +E  +      Q  R  Q   Q + L + Q  R++L   Q LL+ ++   E  +E
Sbjct: 1181 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 96/471 (20%), Positives = 187/471 (39%), Gaps = 57/471 (12%)

Query: 918  LEGHLQSAQK-----------ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            LEG +Q+ Q            E++  + H+  L+ +K Q+ +  E  E L++ + +LQ E
Sbjct: 314  LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK-QLRSEFERLECLQRIVTKLQME 372

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            A     +  Q    L SD+                A G + +R  E     + AD+ +  
Sbjct: 373  AGLCEEQLNQADALLQSDVRLL-------------AAGKVPQRAGEVERDLDKADSMIRL 419

Query: 1027 L-----RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            L       + G       ++ R+  L   L A+   +T     L+  +A  + ++ +   
Sbjct: 420  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTL 476

Query: 1082 KVLELEDELQES--RGFRKKIKRLEESNKKL--------ALELEHEKGKLTGLGQSNAAL 1131
            + ++   EL++S  R  +  +  +EE+  ++           +E + G   GL QS    
Sbjct: 477  QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF 536

Query: 1132 R---------EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
            R         E      T  A R+  L +L+LQ   +L   +   R ++ L  +  A+  
Sbjct: 537  RAKIERARSDEGQLSPATRGAYRDC-LGRLDLQYAKLLNSSKARLRSLESL-HSFVAAAT 594

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
            KE   +N  +E+      +      +  A     S + +EL+ KE  +++LQ   D L  
Sbjct: 595  KELMWLNEKEEEEVG--FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 652

Query: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
             +      +  FQA L    + +  L   ++  L +     Q   +++    Q ++  ++
Sbjct: 653  EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 712

Query: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLS-MTQKDKFMLQAK 1352
            L+++           LE L Q  Q+ K +L   +  LS + ++ K ++Q K
Sbjct: 713  LRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 763


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  185 bits (469), Expect = 3e-46
 Identities = 228/1070 (21%), Positives = 458/1070 (42%), Gaps = 119/1070 (11%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E   AE +E + +V     +     EA +   +QA +E  ELQ ++     ++  + E +
Sbjct: 1489 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA 1545

Query: 457  HSSQQRQDSLSSEVDTLKQS-----------CWDLERAMTDLQNMLEAKNASLASSNNDL 505
              +QQ++ S+  E+  L+QS               ER+   ++  +      L ++    
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605

Query: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
              AE + Q L A+ E+ +            LR+Q+     + +Q ++E   L S++KA +
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE---LASRVKA-E 1661

Query: 566  AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLT 625
            AE +         ++Q AL     +RLQ E A  ++ Q      +E  +   V+L     
Sbjct: 1662 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQR 1709

Query: 626  ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA---KTMVEEDLQRRLEEFEGERE 682
              +     ++   A +   +E  + ++  A  Q++E    +   + + +R  EE E E E
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769

Query: 683  RLQRMADSAASLEQQLEQV----KLTLLQRDQQLEALQQE-------HLDLMKQLTLTQE 731
            R Q  A+ A  L  Q E+V     L   + ++Q E  ++E           ++Q  L ++
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829

Query: 732  ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
             L+ + Q  +         +  L  L+ E    E    LL+ E   L+    AA   ++E
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889

Query: 792  LDRGARRLE-----------EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            L+    ++               EE+  T EK ++ L  ++G+   L +E A L+   ++
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1949

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRT 896
             K Q  +Q    +A R+ A ++  L  +L    +ATR + ++E+  L+++  +    +R 
Sbjct: 1950 AKRQ--RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA-LKEKEAENERLRRL 2006

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE--------METHLQSLQFDKEQMVA 948
            AE E  +  R   Q  QH AD+E  L   +K  D         +E  L+  +  +E+++A
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066

Query: 949  V----------------------TEANEALK-KQIEELQQEARKAITEQKQKMRRLGSDL 985
            +                      + A + L+ K+  EL+   ++ +  ++++ RR   + 
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126

Query: 986  T----SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG-QLRAQGGSSDSSLAL 1040
                 +A++E   + KA    V  L  +++EA   +E A+ E   QL+    ++   L  
Sbjct: 2127 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2186

Query: 1041 HER-----IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095
             E+     +Q  E ELQ     +  +  +L+       +  EE+ E  ++ E E  +SR 
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2246

Query: 1096 FRKKIKRLEESNKKLA---LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
              ++ +RL++S ++ A    + +    KL    +  AA R      + AL +++A   ++
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEM 2304

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
                +   Q   ++  Q++  +  L+  LE+   + N L E++   K EA    R     
Sbjct: 2305 EKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2363

Query: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
              EL  V+ +++    L  +++AE   L +R+  ++Q   Q +AE            KQ+
Sbjct: 2364 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK----------MKQV 2413

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
             E+ ++  V  QE   L+   ++   + ++L +++   + Q  +E   L+   + ++ + 
Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            E+AQE     Q+DK  +  +++E     +  L+  +Q +L++   A + +
Sbjct: 2474 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523



 Score =  180 bits (456), Expect = 1e-44
 Identities = 270/1151 (23%), Positives = 491/1151 (42%), Gaps = 185/1151 (16%)

Query: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
            Q  A   + Q Q+ +   R     + S V  E+ AA  ++  LQ L+E   L  Q E   
Sbjct: 1630 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAE 1686

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
                QA  E+A  Q Q+A  + +  A+ E     Q ++ S + +   L++S  +   A+ 
Sbjct: 1687 RRLRQAEVERAR-QVQVALETAQRSAEAEL----QSKRASFAEKTAQLERSLQEEHVAVA 1741

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD---------- 535
             L+   E +    A +    + AE + +R   K  +  R  L  +               
Sbjct: 1742 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1801

Query: 536  -------------------LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
                               +RQ+  A Q   +Q QL   T   +L A Q E+  L++  +
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETE 1860

Query: 577  WYQQQLALAQEARVRLQGEMAHI-QVGQMTQAGLLE-HLKLENVSLSQQLTETQHRSMKE 634
              +QQ  L +E   RLQ E A   Q  Q  +A L +   ++E +  S+   E + RS  E
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920

Query: 635  KGRIAAQLQGIEADMLDQEAAFMQI--QEAKT---MVEEDLQRR---------------- 673
            K +   + +      L +EAA ++   +EAK    + EED  R+                
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980

Query: 674  ------------LEEFEGERERLQRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQ 717
                        L+E E E ERL+R+A+  A     LE+Q  Q K  + +R  QL     
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040

Query: 718  EHLDLMKQLTLTQEALQSR---EQSLDALQTHYDELQARLGELQGEA----ASREDTICL 770
              L+  +Q  L ++ L+ R   E+ + AL+  +++  A   EL+ E     ++ EDT  L
Sbjct: 2041 SELE--RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT--L 2096

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
               E+  LEAA Q   + +EE     RR  E  E   ++L    E    +   +E +++ 
Sbjct: 2097 RSKEQAELEAARQRQLAAEEE-----RRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
             A ++ + ++++E+  Q+        ++A  K +L +E KA    +  + +EL+Q L Q 
Sbjct: 2152 KAKVE-EARRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2209

Query: 891  HG--EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                ++   EAE +R   E A+  +  A+ E     A + R ++E   +  Q  +EQ  A
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQA 2264

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR 1008
              +A  A +K  +E +QEA +    ++  +R+      +A  EM+ KHK +         
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QAADAEME-KHKKFA-------- 2311

Query: 1009 RLQEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKEL-- 1065
              ++ L  K   + EL  LR Q   +D     L E +Q L+AE    +  ++ +E+EL  
Sbjct: 2312 --EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369

Query: 1066 -----QEVIALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKG 1119
                 +E+  L ++   E+R  +L  +D  Q   +   +K+K++ E   +L++  + E  
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAA 2428

Query: 1120 KLTGLGQSNAA---------LREH-NSILETALAKREADLVQLNLQVQAVLQRKEEEDR- 1168
            +L  L + + A         L+E   ++ E    K EA+L+Q   ++     R+ +ED+ 
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488

Query: 1169 ----QMKHLVQALQASLEKEKEK-------VNSLKEQVAA---AKVEAGHNRRHFKAASL 1214
                Q+    Q  Q +LE E+++          LK +VA    A+  A  + + F+  + 
Sbjct: 2489 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548

Query: 1215 ELSEV--KKELQAKEHL-------VQKLQAEADDLQIREG-----------KHSQEIAQF 1254
            E+ E   + EL  +E +       +Q+ Q++ D  ++RE            +   ++ Q 
Sbjct: 2549 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2608

Query: 1255 QAELAEARAQLQLLQK----------QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
            ++E  +   Q QLLQ+          + D  L ++    QE   L+     +  + Q L+
Sbjct: 2609 KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR 2668

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
            ++    +QQ  +E + L   ++  +     A+E +   Q++   LQ    + +   + L 
Sbjct: 2669 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQEELLA 2725

Query: 1365 QQNQQLKLDLR 1375
            ++NQ+L+  L+
Sbjct: 2726 EENQRLREQLQ 2736



 Score =  155 bits (392), Expect = 3e-37
 Identities = 253/1169 (21%), Positives = 477/1169 (40%), Gaps = 174/1169 (14%)

Query: 393  SVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQALKEKAELQAQLA-----AL 445
            ++SL     +  EE+L+  +E+++    + A    LEA++A  +K   QA+       AL
Sbjct: 1227 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1286

Query: 446  STKLQAQVECSHSSQQRQDSLSSEVDTLKQSC------WDLERAMTDL-QNMLEAKNASL 498
              +L+   E     QQR      EV+  ++        W    A TD+ Q  LE     L
Sbjct: 1287 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1346

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
                          Q    + E +Q   L+    V   R+Q+   Q+ L++++     + 
Sbjct: 1347 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV---REQLRQEQALLEEIERHGEKVE 1403

Query: 559  SKLKASQAEISSLQSVRQWYQQQLAL--AQEARVRLQGEMAHIQVGQMTQAGLLEHLKL- 615
               + ++  I++++     Y+ QL    AQ   V    +   +Q G  +++ + E++ L 
Sbjct: 1404 ECQRFAKQYINAIKD----YELQLVTYKAQLEPVASPAKKPKVQSG--SESVIQEYVDLR 1457

Query: 616  ----ENVSLSQQ----LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
                E  +L+ Q    ++ET  R M+E+ R+A Q +  E +                   
Sbjct: 1458 THYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERE------------------- 1497

Query: 668  EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH--LDLMKQ 725
                 RL E E   E+ +++A++ A  + Q E+    L QR Q+ E +++E   +D  +Q
Sbjct: 1498 -----RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQ 1551

Query: 726  LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR---EDTICLLQNEKIILEAAL 782
                QE LQ   QS +A      E+QA+  + +    SR   E+ I +++ +    E   
Sbjct: 1552 KRSIQEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605

Query: 783  QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
              A+   + L   A   E    +  E  E+LR ++  +S +    + E A+  K   +  
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665

Query: 843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKR-----LDSELKELRQELMQVHGE--KR 895
             +  +    +E  R  A   ++ + + +  R R     L++  +    EL        ++
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725

Query: 896  TAEAE--LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
            TA+ E  L   H  VAQ+R+           A++ R+E E  L+  Q    + + +    
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785

Query: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
            E + +Q    Q EA K   E +++ RR G     A ++ +   +  E    +     Q+ 
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845

Query: 1014 LAAKE-----AADAELGQLRAQ-------------GGSSDSSLALHERIQALEAELQAVS 1055
            LAA++      A+ E G+ + Q               ++     L   +  + AE++ + 
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR----LEESNKKLA 1111
             SK   E+E +     + Q LE    +  EL +E    R   ++ KR     EE   +  
Sbjct: 1906 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1965

Query: 1112 LELEHEKG-KLTGLG-------QSNAALREHNS-----------------ILETALAKRE 1146
             E E     KL  +G       ++  AL+E  +                  LE   A+ +
Sbjct: 1966 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 2025

Query: 1147 AD----LVQLNLQVQAVLQRKE-------EEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
            AD    L QL     + L+R++        + RQ++  + AL+AS EK       L+ ++
Sbjct: 2026 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 2085

Query: 1196 AAAKVEAGHNRRHFKAASLELS--------EVKKELQAKEHLVQKLQAEADDLQIREGKH 1247
               +  A    R  + A LE +        E ++  +A+E + + L AE +  + R+   
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA- 2144

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER--EIQSLKQ 1305
             +E+ + +A++ EAR     L+++ +++ ++Q    QE    + + ++K     +Q  +Q
Sbjct: 2145 LEEVERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2200

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
            +L  T QQ +  L+ L+   +  +   E A+E     +++    + +V E +  +K   +
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAE 2259

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  Q +   +  A K RKE + EA+                A   +  LR   A   E  
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARR--------------AQAEQAALRQKQAADAEME 2305

Query: 1426 KNLNSCLQ------QLKQEMDSLQRQMEE 1448
            K+     Q      Q++QE+ +L+ Q+EE
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334



 Score =  117 bits (293), Expect = 8e-26
 Identities = 167/735 (22%), Positives = 311/735 (42%), Gaps = 115/735 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE-A 423
            LQ    + Q    ++ GE  + R           +A E +E  +Q  +E  +   Q+E A
Sbjct: 2202 LQQTLQQEQSVLDQLRGEAEAAR----------RAAEEAEEARVQAEREAAQSRRQVEEA 2251

Query: 424  LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL------SSEVDTLKQSC 477
              L+ S   + +A  QAQ AA   + +A+ E +  +Q  Q +L       +E++  K+  
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
                R    ++  L      L  +++   + +E+ QRL A+  +  R     +  +  +R
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371

Query: 538  QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
             QM  L     +++ E   L  + K          + +++ Q++     E   ++  E A
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDK---------DNTQRFLQEEA----EKMKQVAEEAA 2418

Query: 598  HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAF 656
             + V    +A  L  L  E+++  + L E   + +KEK      +Q + EA  L  EA  
Sbjct: 2419 RLSVAAQ-EAARLRQLAEEDLAQQRALAE---KMLKEK------MQAVQEATRLKAEAEL 2468

Query: 657  MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            +Q Q  K + +E  +R  E+ E   +  Q++A+     ++ LE       +R +QLE   
Sbjct: 2469 LQQQ--KELAQEQARRLQEDKE---QMAQQLAEETQGFQRTLEA------ERQRQLE--- 2514

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
                     ++   E L+ R   +   Q   +E   R  +   E   +     L   EK+
Sbjct: 2515 ---------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2565

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE---LAIKSGQVEHLQ----- 828
             L   +Q  +  +++ D  A RL E   E     EKL++E   L +KS +++ +Q     
Sbjct: 2566 TL---VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
            QET AL++     K+  LQ++  +E   ++    +QL  +  A  ++L  E +  +Q++ 
Sbjct: 2623 QETQALQQSFLSEKDSLLQRERFIE---QEKAKLEQLFQDEVAKAQQLREEQQRQQQQM- 2678

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                     E E  RL   + + R+   + E  ++  Q+E  ++E      Q  ++Q   
Sbjct: 2679 ---------EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE------QQRRQQEEL 2723

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQ---------KMRRLGSD-LTSAQKEMKTKHKA 998
            + E N+ L++Q++ L+++ R A+   ++         K    G D L     E + +H  
Sbjct: 2724 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF 2783

Query: 999  YENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSH 1056
                  + ++RLQEA  L+A+E       Q  AQG ++   LA  E ++     LQ  S 
Sbjct: 2784 DGLRRKVSAQRLQEAGILSAEEL------QRLAQGHTTVDELARREDVRHY---LQGRSS 2834

Query: 1057 SKTLLEKELQEVIAL 1071
               LL K   E +++
Sbjct: 2835 IAGLLLKATNEKLSV 2849



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 181/955 (18%), Positives = 363/955 (38%), Gaps = 94/955 (9%)

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVE-CSHSSQQRQDSLSSEVDTLK--- 474
            G+L    LE  + L+ + E    L  + TKLQ +   C     Q    L S+V  L    
Sbjct: 508  GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGK 567

Query: 475  --QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
              Q   ++ER +    +M+      + +  +      EQ  R + ++ +   ++ ++ N 
Sbjct: 568  VPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 627

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
               L+  + A  +Q+ QV     TL S  +  + E S+L+    + Q  LA  +E + R+
Sbjct: 628  --RLKAGVAAPATQVAQV-----TLQSVQRRPELEDSTLR----YLQDLLAWVEENQHRV 676

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
             G    + +  + +A L  H  L      ++      R+  ++G+++   +G   D L +
Sbjct: 677  DGAEWGVDLPSV-EAQLGSHRGLHQSI--EEFRAKIERARSDEGQLSPATRGAYRDCLGR 733

Query: 653  EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTLLQRDQQ 711
                + +Q AK +     + RL   E     +         L E++ E+V      R+  
Sbjct: 734  ----LDLQYAKLL--NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 787

Query: 712  LEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE----------- 760
            + A ++ +  LM++L L ++ ++  + + D L       +  +   Q             
Sbjct: 788  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 847

Query: 761  ----AASREDTICLLQNEKIILEA-----ALQAAKSGKEELDRGA--RRLEEGTEETSET 809
                 A  ++     Q    + EA      LQ A   K   DR A   RLE+  ++  + 
Sbjct: 848  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 907

Query: 810  LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
             E+L E      G +  L +   A+ +   +     ++ ++ + A       K   ++  
Sbjct: 908  KEQLNE----YKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV---CDYKQVEVTVH 960

Query: 870  KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
            K    +L    +    +++   G +    +    +     + ++ +  LE   Q+     
Sbjct: 961  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 1020

Query: 930  DEMETHLQSL---QFDKEQMVAVTEANEALKKQIE-ELQQEARKAITEQKQKMRRLGSDL 985
             ++   ++SL   Q  +  +  +   + A  + ++ E Q++A  ++    Q   R   D 
Sbjct: 1021 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1080

Query: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
                 E +      E   G  S   Q+ L + E           QG   +S      R Q
Sbjct: 1081 GGFGPEDRL---MAEREYGSCSHHYQQLLQSLE-----------QGAQEES------RCQ 1120

Query: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105
               +EL+ +      L+ E  E   +    L   +E   E    + E +  + +++ L +
Sbjct: 1121 RCISELKDIR-----LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1175

Query: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE--ADLVQLNLQVQAVLQRK 1163
               +L+ E E    K+  L + + A     S LE  L K E    L  + L+    +   
Sbjct: 1176 GVARLSAEAE----KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231

Query: 1164 EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKEL 1223
                +  + +++A +  L KE + V +   ++ A K      R   +A       ++ EL
Sbjct: 1232 IRGTQGAEEVLRAHEEQL-KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1290

Query: 1224 QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
            +  + + ++LQ    +  +   +  + +AQ         AQ  + Q++L EQL +Q    
Sbjct: 1291 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL-EQLGRQLRYY 1349

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQE 1337
            +E  +      Q  R  Q   Q + L + Q  R++L   Q LL+ ++   E  +E
Sbjct: 1350 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 96/471 (20%), Positives = 187/471 (39%), Gaps = 57/471 (12%)

Query: 918  LEGHLQSAQK-----------ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            LEG +Q+ Q            E++  + H+  L+ +K Q+ +  E  E L++ + +LQ E
Sbjct: 483  LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK-QLRSEFERLECLQRIVTKLQME 541

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            A     +  Q    L SD+                A G + +R  E     + AD+ +  
Sbjct: 542  AGLCEEQLNQADALLQSDVRLL-------------AAGKVPQRAGEVERDLDKADSMIRL 588

Query: 1027 L-----RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            L       + G       ++ R+  L   L A+   +T     L+  +A  + ++ +   
Sbjct: 589  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTL 645

Query: 1082 KVLELEDELQES--RGFRKKIKRLEESNKKL--------ALELEHEKGKLTGLGQSNAAL 1131
            + ++   EL++S  R  +  +  +EE+  ++           +E + G   GL QS    
Sbjct: 646  QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF 705

Query: 1132 R---------EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
            R         E      T  A R+  L +L+LQ   +L   +   R ++ L  +  A+  
Sbjct: 706  RAKIERARSDEGQLSPATRGAYRDC-LGRLDLQYAKLLNSSKARLRSLESL-HSFVAAAT 763

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
            KE   +N  +E+      +      +  A     S + +EL+ KE  +++LQ   D L  
Sbjct: 764  KELMWLNEKEEEEVG--FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 821

Query: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
             +      +  FQA L    + +  L   ++  L +     Q   +++    Q ++  ++
Sbjct: 822  EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 881

Query: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLS-MTQKDKFMLQAK 1352
            L+++           LE L Q  Q+ K +L   +  LS + ++ K ++Q K
Sbjct: 882  LRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 932


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  185 bits (469), Expect = 3e-46
 Identities = 228/1070 (21%), Positives = 458/1070 (42%), Gaps = 119/1070 (11%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E   AE +E + +V     +     EA +   +QA +E  ELQ ++     ++  + E +
Sbjct: 1330 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA 1386

Query: 457  HSSQQRQDSLSSEVDTLKQS-----------CWDLERAMTDLQNMLEAKNASLASSNNDL 505
              +QQ++ S+  E+  L+QS               ER+   ++  +      L ++    
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446

Query: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
              AE + Q L A+ E+ +            LR+Q+     + +Q ++E   L S++KA +
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE---LASRVKA-E 1502

Query: 566  AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLT 625
            AE +         ++Q AL     +RLQ E A  ++ Q      +E  +   V+L     
Sbjct: 1503 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQR 1550

Query: 626  ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA---KTMVEEDLQRRLEEFEGERE 682
              +     ++   A +   +E  + ++  A  Q++E    +   + + +R  EE E E E
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610

Query: 683  RLQRMADSAASLEQQLEQV----KLTLLQRDQQLEALQQE-------HLDLMKQLTLTQE 731
            R Q  A+ A  L  Q E+V     L   + ++Q E  ++E           ++Q  L ++
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670

Query: 732  ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
             L+ + Q  +         +  L  L+ E    E    LL+ E   L+    AA   ++E
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730

Query: 792  LDRGARRLE-----------EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            L+    ++               EE+  T EK ++ L  ++G+   L +E A L+   ++
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1790

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRT 896
             K Q  +Q    +A R+ A ++  L  +L    +ATR + ++E+  L+++  +    +R 
Sbjct: 1791 AKRQ--RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA-LKEKEAENERLRRL 1847

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE--------METHLQSLQFDKEQMVA 948
            AE E  +  R   Q  QH AD+E  L   +K  D         +E  L+  +  +E+++A
Sbjct: 1848 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1907

Query: 949  V----------------------TEANEALK-KQIEELQQEARKAITEQKQKMRRLGSDL 985
            +                      + A + L+ K+  EL+   ++ +  ++++ RR   + 
Sbjct: 1908 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967

Query: 986  T----SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG-QLRAQGGSSDSSLAL 1040
                 +A++E   + KA    V  L  +++EA   +E A+ E   QL+    ++   L  
Sbjct: 1968 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2027

Query: 1041 HER-----IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095
             E+     +Q  E ELQ     +  +  +L+       +  EE+ E  ++ E E  +SR 
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2087

Query: 1096 FRKKIKRLEESNKKLA---LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
              ++ +RL++S ++ A    + +    KL    +  AA R      + AL +++A   ++
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEM 2145

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
                +   Q   ++  Q++  +  L+  LE+   + N L E++   K EA    R     
Sbjct: 2146 EKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2204

Query: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
              EL  V+ +++    L  +++AE   L +R+  ++Q   Q +AE            KQ+
Sbjct: 2205 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK----------MKQV 2254

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
             E+ ++  V  QE   L+   ++   + ++L +++   + Q  +E   L+   + ++ + 
Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            E+AQE     Q+DK  +  +++E     +  L+  +Q +L++   A + +
Sbjct: 2315 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364



 Score =  180 bits (456), Expect = 1e-44
 Identities = 270/1151 (23%), Positives = 491/1151 (42%), Gaps = 185/1151 (16%)

Query: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
            Q  A   + Q Q+ +   R     + S V  E+ AA  ++  LQ L+E   L  Q E   
Sbjct: 1471 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAE 1527

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
                QA  E+A  Q Q+A  + +  A+ E     Q ++ S + +   L++S  +   A+ 
Sbjct: 1528 RRLRQAEVERAR-QVQVALETAQRSAEAEL----QSKRASFAEKTAQLERSLQEEHVAVA 1582

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD---------- 535
             L+   E +    A +    + AE + +R   K  +  R  L  +               
Sbjct: 1583 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1642

Query: 536  -------------------LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
                               +RQ+  A Q   +Q QL   T   +L A Q E+  L++  +
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETE 1701

Query: 577  WYQQQLALAQEARVRLQGEMAHI-QVGQMTQAGLLE-HLKLENVSLSQQLTETQHRSMKE 634
              +QQ  L +E   RLQ E A   Q  Q  +A L +   ++E +  S+   E + RS  E
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1761

Query: 635  KGRIAAQLQGIEADMLDQEAAFMQI--QEAKT---MVEEDLQRR---------------- 673
            K +   + +      L +EAA ++   +EAK    + EED  R+                
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821

Query: 674  ------------LEEFEGERERLQRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQ 717
                        L+E E E ERL+R+A+  A     LE+Q  Q K  + +R  QL     
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881

Query: 718  EHLDLMKQLTLTQEALQSR---EQSLDALQTHYDELQARLGELQGEA----ASREDTICL 770
              L+  +Q  L ++ L+ R   E+ + AL+  +++  A   EL+ E     ++ EDT  L
Sbjct: 1882 SELE--RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT--L 1937

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
               E+  LEAA Q   + +EE     RR  E  E   ++L    E    +   +E +++ 
Sbjct: 1938 RSKEQAELEAARQRQLAAEEE-----RRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
             A ++ + ++++E+  Q+        ++A  K +L +E KA    +  + +EL+Q L Q 
Sbjct: 1993 KAKVE-EARRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2050

Query: 891  HG--EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                ++   EAE +R   E A+  +  A+ E     A + R ++E   +  Q  +EQ  A
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQA 2105

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR 1008
              +A  A +K  +E +QEA +    ++  +R+      +A  EM+ KHK +         
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QAADAEME-KHKKFA-------- 2152

Query: 1009 RLQEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKEL-- 1065
              ++ L  K   + EL  LR Q   +D     L E +Q L+AE    +  ++ +E+EL  
Sbjct: 2153 --EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2210

Query: 1066 -----QEVIALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKG 1119
                 +E+  L ++   E+R  +L  +D  Q   +   +K+K++ E   +L++  + E  
Sbjct: 2211 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAA 2269

Query: 1120 KLTGLGQSNAA---------LREH-NSILETALAKREADLVQLNLQVQAVLQRKEEEDR- 1168
            +L  L + + A         L+E   ++ E    K EA+L+Q   ++     R+ +ED+ 
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329

Query: 1169 ----QMKHLVQALQASLEKEKEK-------VNSLKEQVAA---AKVEAGHNRRHFKAASL 1214
                Q+    Q  Q +LE E+++          LK +VA    A+  A  + + F+  + 
Sbjct: 2330 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389

Query: 1215 ELSEV--KKELQAKEHL-------VQKLQAEADDLQIREG-----------KHSQEIAQF 1254
            E+ E   + EL  +E +       +Q+ Q++ D  ++RE            +   ++ Q 
Sbjct: 2390 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2449

Query: 1255 QAELAEARAQLQLLQK----------QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
            ++E  +   Q QLLQ+          + D  L ++    QE   L+     +  + Q L+
Sbjct: 2450 KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR 2509

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
            ++    +QQ  +E + L   ++  +     A+E +   Q++   LQ    + +   + L 
Sbjct: 2510 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQEELLA 2566

Query: 1365 QQNQQLKLDLR 1375
            ++NQ+L+  L+
Sbjct: 2567 EENQRLREQLQ 2577



 Score =  155 bits (392), Expect = 3e-37
 Identities = 253/1169 (21%), Positives = 477/1169 (40%), Gaps = 174/1169 (14%)

Query: 393  SVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQALKEKAELQAQLA-----AL 445
            ++SL     +  EE+L+  +E+++    + A    LEA++A  +K   QA+       AL
Sbjct: 1068 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1127

Query: 446  STKLQAQVECSHSSQQRQDSLSSEVDTLKQSC------WDLERAMTDL-QNMLEAKNASL 498
              +L+   E     QQR      EV+  ++        W    A TD+ Q  LE     L
Sbjct: 1128 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1187

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
                          Q    + E +Q   L+    V   R+Q+   Q+ L++++     + 
Sbjct: 1188 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV---REQLRQEQALLEEIERHGEKVE 1244

Query: 559  SKLKASQAEISSLQSVRQWYQQQLAL--AQEARVRLQGEMAHIQVGQMTQAGLLEHLKL- 615
               + ++  I++++     Y+ QL    AQ   V    +   +Q G  +++ + E++ L 
Sbjct: 1245 ECQRFAKQYINAIKD----YELQLVTYKAQLEPVASPAKKPKVQSG--SESVIQEYVDLR 1298

Query: 616  ----ENVSLSQQ----LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
                E  +L+ Q    ++ET  R M+E+ R+A Q +  E +                   
Sbjct: 1299 THYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERE------------------- 1338

Query: 668  EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH--LDLMKQ 725
                 RL E E   E+ +++A++ A  + Q E+    L QR Q+ E +++E   +D  +Q
Sbjct: 1339 -----RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQ 1392

Query: 726  LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR---EDTICLLQNEKIILEAAL 782
                QE LQ   QS +A      E+QA+  + +    SR   E+ I +++ +    E   
Sbjct: 1393 KRSIQEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446

Query: 783  QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
              A+   + L   A   E    +  E  E+LR ++  +S +    + E A+  K   +  
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506

Query: 843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKR-----LDSELKELRQELMQVHGE--KR 895
             +  +    +E  R  A   ++ + + +  R R     L++  +    EL        ++
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566

Query: 896  TAEAE--LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
            TA+ E  L   H  VAQ+R+           A++ R+E E  L+  Q    + + +    
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626

Query: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
            E + +Q    Q EA K   E +++ RR G     A ++ +   +  E    +     Q+ 
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686

Query: 1014 LAAKE-----AADAELGQLRAQ-------------GGSSDSSLALHERIQALEAELQAVS 1055
            LAA++      A+ E G+ + Q               ++     L   +  + AE++ + 
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1746

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR----LEESNKKLA 1111
             SK   E+E +     + Q LE    +  EL +E    R   ++ KR     EE   +  
Sbjct: 1747 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1806

Query: 1112 LELEHEKG-KLTGLG-------QSNAALREHNS-----------------ILETALAKRE 1146
             E E     KL  +G       ++  AL+E  +                  LE   A+ +
Sbjct: 1807 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1866

Query: 1147 AD----LVQLNLQVQAVLQRKE-------EEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
            AD    L QL     + L+R++        + RQ++  + AL+AS EK       L+ ++
Sbjct: 1867 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1926

Query: 1196 AAAKVEAGHNRRHFKAASLELS--------EVKKELQAKEHLVQKLQAEADDLQIREGKH 1247
               +  A    R  + A LE +        E ++  +A+E + + L AE +  + R+   
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA- 1985

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER--EIQSLKQ 1305
             +E+ + +A++ EAR     L+++ +++ ++Q    QE    + + ++K     +Q  +Q
Sbjct: 1986 LEEVERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2041

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
            +L  T QQ +  L+ L+   +  +   E A+E     +++    + +V E +  +K   +
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAE 2100

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  Q +   +  A K RKE + EA+                A   +  LR   A   E  
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARR--------------AQAEQAALRQKQAADAEME 2146

Query: 1426 KNLNSCLQ------QLKQEMDSLQRQMEE 1448
            K+     Q      Q++QE+ +L+ Q+EE
Sbjct: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175



 Score =  117 bits (293), Expect = 8e-26
 Identities = 167/735 (22%), Positives = 311/735 (42%), Gaps = 115/735 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE-A 423
            LQ    + Q    ++ GE  + R           +A E +E  +Q  +E  +   Q+E A
Sbjct: 2043 LQQTLQQEQSVLDQLRGEAEAAR----------RAAEEAEEARVQAEREAAQSRRQVEEA 2092

Query: 424  LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL------SSEVDTLKQSC 477
              L+ S   + +A  QAQ AA   + +A+ E +  +Q  Q +L       +E++  K+  
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
                R    ++  L      L  +++   + +E+ QRL A+  +  R     +  +  +R
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212

Query: 538  QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
             QM  L     +++ E   L  + K          + +++ Q++     E   ++  E A
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDK---------DNTQRFLQEEA----EKMKQVAEEAA 2259

Query: 598  HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAF 656
             + V    +A  L  L  E+++  + L E   + +KEK      +Q + EA  L  EA  
Sbjct: 2260 RLSVAAQ-EAARLRQLAEEDLAQQRALAE---KMLKEK------MQAVQEATRLKAEAEL 2309

Query: 657  MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            +Q Q  K + +E  +R  E+ E   +  Q++A+     ++ LE       +R +QLE   
Sbjct: 2310 LQQQ--KELAQEQARRLQEDKE---QMAQQLAEETQGFQRTLEA------ERQRQLE--- 2355

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
                     ++   E L+ R   +   Q   +E   R  +   E   +     L   EK+
Sbjct: 2356 ---------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2406

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE---LAIKSGQVEHLQ----- 828
             L   +Q  +  +++ D  A RL E   E     EKL++E   L +KS +++ +Q     
Sbjct: 2407 TL---VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2463

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
            QET AL++     K+  LQ++  +E   ++    +QL  +  A  ++L  E +  +Q++ 
Sbjct: 2464 QETQALQQSFLSEKDSLLQRERFIE---QEKAKLEQLFQDEVAKAQQLREEQQRQQQQM- 2519

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                     E E  RL   + + R+   + E  ++  Q+E  ++E      Q  ++Q   
Sbjct: 2520 ---------EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE------QQRRQQEEL 2564

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQ---------KMRRLGSD-LTSAQKEMKTKHKA 998
            + E N+ L++Q++ L+++ R A+   ++         K    G D L     E + +H  
Sbjct: 2565 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF 2624

Query: 999  YENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSH 1056
                  + ++RLQEA  L+A+E       Q  AQG ++   LA  E ++     LQ  S 
Sbjct: 2625 DGLRRKVSAQRLQEAGILSAEEL------QRLAQGHTTVDELARREDVRHY---LQGRSS 2675

Query: 1057 SKTLLEKELQEVIAL 1071
               LL K   E +++
Sbjct: 2676 IAGLLLKATNEKLSV 2690



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 181/955 (18%), Positives = 363/955 (38%), Gaps = 94/955 (9%)

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVE-CSHSSQQRQDSLSSEVDTLK--- 474
            G+L    LE  + L+ + E    L  + TKLQ +   C     Q    L S+V  L    
Sbjct: 349  GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGK 408

Query: 475  --QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
              Q   ++ER +    +M+      + +  +      EQ  R + ++ +   ++ ++ N 
Sbjct: 409  VPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 468

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
               L+  + A  +Q+ QV     TL S  +  + E S+L+    + Q  LA  +E + R+
Sbjct: 469  --RLKAGVAAPATQVAQV-----TLQSVQRRPELEDSTLR----YLQDLLAWVEENQHRV 517

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
             G    + +  + +A L  H  L      ++      R+  ++G+++   +G   D L +
Sbjct: 518  DGAEWGVDLPSV-EAQLGSHRGLHQSI--EEFRAKIERARSDEGQLSPATRGAYRDCLGR 574

Query: 653  EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTLLQRDQQ 711
                + +Q AK +     + RL   E     +         L E++ E+V      R+  
Sbjct: 575  ----LDLQYAKLL--NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 628

Query: 712  LEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE----------- 760
            + A ++ +  LM++L L ++ ++  + + D L       +  +   Q             
Sbjct: 629  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 688

Query: 761  ----AASREDTICLLQNEKIILEA-----ALQAAKSGKEELDRGA--RRLEEGTEETSET 809
                 A  ++     Q    + EA      LQ A   K   DR A   RLE+  ++  + 
Sbjct: 689  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 748

Query: 810  LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
             E+L E      G +  L +   A+ +   +     ++ ++ + A       K   ++  
Sbjct: 749  KEQLNE----YKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV---CDYKQVEVTVH 801

Query: 870  KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
            K    +L    +    +++   G +    +    +     + ++ +  LE   Q+     
Sbjct: 802  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 861

Query: 930  DEMETHLQSL---QFDKEQMVAVTEANEALKKQIE-ELQQEARKAITEQKQKMRRLGSDL 985
             ++   ++SL   Q  +  +  +   + A  + ++ E Q++A  ++    Q   R   D 
Sbjct: 862  HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 921

Query: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
                 E +      E   G  S   Q+ L + E           QG   +S      R Q
Sbjct: 922  GGFGPEDRL---MAEREYGSCSHHYQQLLQSLE-----------QGAQEES------RCQ 961

Query: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105
               +EL+ +      L+ E  E   +    L   +E   E    + E +  + +++ L +
Sbjct: 962  RCISELKDIR-----LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1016

Query: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE--ADLVQLNLQVQAVLQRK 1163
               +L+ E E    K+  L + + A     S LE  L K E    L  + L+    +   
Sbjct: 1017 GVARLSAEAE----KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072

Query: 1164 EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKEL 1223
                +  + +++A +  L KE + V +   ++ A K      R   +A       ++ EL
Sbjct: 1073 IRGTQGAEEVLRAHEEQL-KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1131

Query: 1224 QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
            +  + + ++LQ    +  +   +  + +AQ         AQ  + Q++L EQL +Q    
Sbjct: 1132 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL-EQLGRQLRYY 1190

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQE 1337
            +E  +      Q  R  Q   Q + L + Q  R++L   Q LL+ ++   E  +E
Sbjct: 1191 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 96/471 (20%), Positives = 187/471 (39%), Gaps = 57/471 (12%)

Query: 918  LEGHLQSAQK-----------ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            LEG +Q+ Q            E++  + H+  L+ +K Q+ +  E  E L++ + +LQ E
Sbjct: 324  LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK-QLRSEFERLECLQRIVTKLQME 382

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            A     +  Q    L SD+                A G + +R  E     + AD+ +  
Sbjct: 383  AGLCEEQLNQADALLQSDVRLL-------------AAGKVPQRAGEVERDLDKADSMIRL 429

Query: 1027 L-----RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            L       + G       ++ R+  L   L A+   +T     L+  +A  + ++ +   
Sbjct: 430  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTL 486

Query: 1082 KVLELEDELQES--RGFRKKIKRLEESNKKL--------ALELEHEKGKLTGLGQSNAAL 1131
            + ++   EL++S  R  +  +  +EE+  ++           +E + G   GL QS    
Sbjct: 487  QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF 546

Query: 1132 R---------EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
            R         E      T  A R+  L +L+LQ   +L   +   R ++ L  +  A+  
Sbjct: 547  RAKIERARSDEGQLSPATRGAYRDC-LGRLDLQYAKLLNSSKARLRSLESL-HSFVAAAT 604

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
            KE   +N  +E+      +      +  A     S + +EL+ KE  +++LQ   D L  
Sbjct: 605  KELMWLNEKEEEEVG--FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 662

Query: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
             +      +  FQA L    + +  L   ++  L +     Q   +++    Q ++  ++
Sbjct: 663  EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 722

Query: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLS-MTQKDKFMLQAK 1352
            L+++           LE L Q  Q+ K +L   +  LS + ++ K ++Q K
Sbjct: 723  LRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 773


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  185 bits (469), Expect = 3e-46
 Identities = 228/1070 (21%), Positives = 458/1070 (42%), Gaps = 119/1070 (11%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E   AE +E + +V     +     EA +   +QA +E  ELQ ++     ++  + E +
Sbjct: 1338 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA 1394

Query: 457  HSSQQRQDSLSSEVDTLKQS-----------CWDLERAMTDLQNMLEAKNASLASSNNDL 505
              +QQ++ S+  E+  L+QS               ER+   ++  +      L ++    
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454

Query: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
              AE + Q L A+ E+ +            LR+Q+     + +Q ++E   L S++KA +
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE---LASRVKA-E 1510

Query: 566  AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLT 625
            AE +         ++Q AL     +RLQ E A  ++ Q      +E  +   V+L     
Sbjct: 1511 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQR 1558

Query: 626  ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA---KTMVEEDLQRRLEEFEGERE 682
              +     ++   A +   +E  + ++  A  Q++E    +   + + +R  EE E E E
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618

Query: 683  RLQRMADSAASLEQQLEQV----KLTLLQRDQQLEALQQE-------HLDLMKQLTLTQE 731
            R Q  A+ A  L  Q E+V     L   + ++Q E  ++E           ++Q  L ++
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678

Query: 732  ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
             L+ + Q  +         +  L  L+ E    E    LL+ E   L+    AA   ++E
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738

Query: 792  LDRGARRLE-----------EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            L+    ++               EE+  T EK ++ L  ++G+   L +E A L+   ++
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1798

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRT 896
             K Q  +Q    +A R+ A ++  L  +L    +ATR + ++E+  L+++  +    +R 
Sbjct: 1799 AKRQ--RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA-LKEKEAENERLRRL 1855

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE--------METHLQSLQFDKEQMVA 948
            AE E  +  R   Q  QH AD+E  L   +K  D         +E  L+  +  +E+++A
Sbjct: 1856 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1915

Query: 949  V----------------------TEANEALK-KQIEELQQEARKAITEQKQKMRRLGSDL 985
            +                      + A + L+ K+  EL+   ++ +  ++++ RR   + 
Sbjct: 1916 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975

Query: 986  T----SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG-QLRAQGGSSDSSLAL 1040
                 +A++E   + KA    V  L  +++EA   +E A+ E   QL+    ++   L  
Sbjct: 1976 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2035

Query: 1041 HER-----IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095
             E+     +Q  E ELQ     +  +  +L+       +  EE+ E  ++ E E  +SR 
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2095

Query: 1096 FRKKIKRLEESNKKLA---LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
              ++ +RL++S ++ A    + +    KL    +  AA R      + AL +++A   ++
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEM 2153

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
                +   Q   ++  Q++  +  L+  LE+   + N L E++   K EA    R     
Sbjct: 2154 EKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2212

Query: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
              EL  V+ +++    L  +++AE   L +R+  ++Q   Q +AE            KQ+
Sbjct: 2213 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK----------MKQV 2262

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
             E+ ++  V  QE   L+   ++   + ++L +++   + Q  +E   L+   + ++ + 
Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            E+AQE     Q+DK  +  +++E     +  L+  +Q +L++   A + +
Sbjct: 2323 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372



 Score =  180 bits (456), Expect = 1e-44
 Identities = 270/1151 (23%), Positives = 491/1151 (42%), Gaps = 185/1151 (16%)

Query: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
            Q  A   + Q Q+ +   R     + S V  E+ AA  ++  LQ L+E   L  Q E   
Sbjct: 1479 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAE 1535

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
                QA  E+A  Q Q+A  + +  A+ E     Q ++ S + +   L++S  +   A+ 
Sbjct: 1536 RRLRQAEVERAR-QVQVALETAQRSAEAEL----QSKRASFAEKTAQLERSLQEEHVAVA 1590

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD---------- 535
             L+   E +    A +    + AE + +R   K  +  R  L  +               
Sbjct: 1591 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1650

Query: 536  -------------------LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
                               +RQ+  A Q   +Q QL   T   +L A Q E+  L++  +
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETE 1709

Query: 577  WYQQQLALAQEARVRLQGEMAHI-QVGQMTQAGLLE-HLKLENVSLSQQLTETQHRSMKE 634
              +QQ  L +E   RLQ E A   Q  Q  +A L +   ++E +  S+   E + RS  E
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1769

Query: 635  KGRIAAQLQGIEADMLDQEAAFMQI--QEAKT---MVEEDLQRR---------------- 673
            K +   + +      L +EAA ++   +EAK    + EED  R+                
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829

Query: 674  ------------LEEFEGERERLQRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQ 717
                        L+E E E ERL+R+A+  A     LE+Q  Q K  + +R  QL     
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889

Query: 718  EHLDLMKQLTLTQEALQSR---EQSLDALQTHYDELQARLGELQGEA----ASREDTICL 770
              L+  +Q  L ++ L+ R   E+ + AL+  +++  A   EL+ E     ++ EDT  L
Sbjct: 1890 SELE--RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT--L 1945

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
               E+  LEAA Q   + +EE     RR  E  E   ++L    E    +   +E +++ 
Sbjct: 1946 RSKEQAELEAARQRQLAAEEE-----RRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2000

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
             A ++ + ++++E+  Q+        ++A  K +L +E KA    +  + +EL+Q L Q 
Sbjct: 2001 KAKVE-EARRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2058

Query: 891  HG--EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                ++   EAE +R   E A+  +  A+ E     A + R ++E   +  Q  +EQ  A
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQA 2113

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR 1008
              +A  A +K  +E +QEA +    ++  +R+      +A  EM+ KHK +         
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QAADAEME-KHKKFA-------- 2160

Query: 1009 RLQEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKEL-- 1065
              ++ L  K   + EL  LR Q   +D     L E +Q L+AE    +  ++ +E+EL  
Sbjct: 2161 --EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2218

Query: 1066 -----QEVIALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKG 1119
                 +E+  L ++   E+R  +L  +D  Q   +   +K+K++ E   +L++  + E  
Sbjct: 2219 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAA 2277

Query: 1120 KLTGLGQSNAA---------LREH-NSILETALAKREADLVQLNLQVQAVLQRKEEEDR- 1168
            +L  L + + A         L+E   ++ E    K EA+L+Q   ++     R+ +ED+ 
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337

Query: 1169 ----QMKHLVQALQASLEKEKEK-------VNSLKEQVAA---AKVEAGHNRRHFKAASL 1214
                Q+    Q  Q +LE E+++          LK +VA    A+  A  + + F+  + 
Sbjct: 2338 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397

Query: 1215 ELSEV--KKELQAKEHL-------VQKLQAEADDLQIREG-----------KHSQEIAQF 1254
            E+ E   + EL  +E +       +Q+ Q++ D  ++RE            +   ++ Q 
Sbjct: 2398 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2457

Query: 1255 QAELAEARAQLQLLQK----------QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
            ++E  +   Q QLLQ+          + D  L ++    QE   L+     +  + Q L+
Sbjct: 2458 KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR 2517

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
            ++    +QQ  +E + L   ++  +     A+E +   Q++   LQ    + +   + L 
Sbjct: 2518 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQEELLA 2574

Query: 1365 QQNQQLKLDLR 1375
            ++NQ+L+  L+
Sbjct: 2575 EENQRLREQLQ 2585



 Score =  155 bits (392), Expect = 3e-37
 Identities = 253/1169 (21%), Positives = 477/1169 (40%), Gaps = 174/1169 (14%)

Query: 393  SVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQALKEKAELQAQLA-----AL 445
            ++SL     +  EE+L+  +E+++    + A    LEA++A  +K   QA+       AL
Sbjct: 1076 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1135

Query: 446  STKLQAQVECSHSSQQRQDSLSSEVDTLKQSC------WDLERAMTDL-QNMLEAKNASL 498
              +L+   E     QQR      EV+  ++        W    A TD+ Q  LE     L
Sbjct: 1136 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1195

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
                          Q    + E +Q   L+    V   R+Q+   Q+ L++++     + 
Sbjct: 1196 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV---REQLRQEQALLEEIERHGEKVE 1252

Query: 559  SKLKASQAEISSLQSVRQWYQQQLAL--AQEARVRLQGEMAHIQVGQMTQAGLLEHLKL- 615
               + ++  I++++     Y+ QL    AQ   V    +   +Q G  +++ + E++ L 
Sbjct: 1253 ECQRFAKQYINAIKD----YELQLVTYKAQLEPVASPAKKPKVQSG--SESVIQEYVDLR 1306

Query: 616  ----ENVSLSQQ----LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
                E  +L+ Q    ++ET  R M+E+ R+A Q +  E +                   
Sbjct: 1307 THYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERE------------------- 1346

Query: 668  EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH--LDLMKQ 725
                 RL E E   E+ +++A++ A  + Q E+    L QR Q+ E +++E   +D  +Q
Sbjct: 1347 -----RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQ 1400

Query: 726  LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR---EDTICLLQNEKIILEAAL 782
                QE LQ   QS +A      E+QA+  + +    SR   E+ I +++ +    E   
Sbjct: 1401 KRSIQEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454

Query: 783  QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
              A+   + L   A   E    +  E  E+LR ++  +S +    + E A+  K   +  
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514

Query: 843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKR-----LDSELKELRQELMQVHGE--KR 895
             +  +    +E  R  A   ++ + + +  R R     L++  +    EL        ++
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574

Query: 896  TAEAE--LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
            TA+ E  L   H  VAQ+R+           A++ R+E E  L+  Q    + + +    
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634

Query: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
            E + +Q    Q EA K   E +++ RR G     A ++ +   +  E    +     Q+ 
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694

Query: 1014 LAAKE-----AADAELGQLRAQ-------------GGSSDSSLALHERIQALEAELQAVS 1055
            LAA++      A+ E G+ + Q               ++     L   +  + AE++ + 
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1754

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR----LEESNKKLA 1111
             SK   E+E +     + Q LE    +  EL +E    R   ++ KR     EE   +  
Sbjct: 1755 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1814

Query: 1112 LELEHEKG-KLTGLG-------QSNAALREHNS-----------------ILETALAKRE 1146
             E E     KL  +G       ++  AL+E  +                  LE   A+ +
Sbjct: 1815 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1874

Query: 1147 AD----LVQLNLQVQAVLQRKE-------EEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
            AD    L QL     + L+R++        + RQ++  + AL+AS EK       L+ ++
Sbjct: 1875 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1934

Query: 1196 AAAKVEAGHNRRHFKAASLELS--------EVKKELQAKEHLVQKLQAEADDLQIREGKH 1247
               +  A    R  + A LE +        E ++  +A+E + + L AE +  + R+   
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA- 1993

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER--EIQSLKQ 1305
             +E+ + +A++ EAR     L+++ +++ ++Q    QE    + + ++K     +Q  +Q
Sbjct: 1994 LEEVERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2049

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
            +L  T QQ +  L+ L+   +  +   E A+E     +++    + +V E +  +K   +
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAE 2108

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  Q +   +  A K RKE + EA+                A   +  LR   A   E  
Sbjct: 2109 EQAQARAQAQAAAEKLRKEAEQEAARR--------------AQAEQAALRQKQAADAEME 2154

Query: 1426 KNLNSCLQ------QLKQEMDSLQRQMEE 1448
            K+     Q      Q++QE+ +L+ Q+EE
Sbjct: 2155 KHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183



 Score =  117 bits (293), Expect = 8e-26
 Identities = 167/735 (22%), Positives = 311/735 (42%), Gaps = 115/735 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE-A 423
            LQ    + Q    ++ GE  + R           +A E +E  +Q  +E  +   Q+E A
Sbjct: 2051 LQQTLQQEQSVLDQLRGEAEAAR----------RAAEEAEEARVQAEREAAQSRRQVEEA 2100

Query: 424  LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL------SSEVDTLKQSC 477
              L+ S   + +A  QAQ AA   + +A+ E +  +Q  Q +L       +E++  K+  
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
                R    ++  L      L  +++   + +E+ QRL A+  +  R     +  +  +R
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220

Query: 538  QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
             QM  L     +++ E   L  + K          + +++ Q++     E   ++  E A
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDK---------DNTQRFLQEEA----EKMKQVAEEAA 2267

Query: 598  HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAF 656
             + V    +A  L  L  E+++  + L E   + +KEK      +Q + EA  L  EA  
Sbjct: 2268 RLSVAAQ-EAARLRQLAEEDLAQQRALAE---KMLKEK------MQAVQEATRLKAEAEL 2317

Query: 657  MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            +Q Q  K + +E  +R  E+ E   +  Q++A+     ++ LE       +R +QLE   
Sbjct: 2318 LQQQ--KELAQEQARRLQEDKE---QMAQQLAEETQGFQRTLEA------ERQRQLE--- 2363

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
                     ++   E L+ R   +   Q   +E   R  +   E   +     L   EK+
Sbjct: 2364 ---------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2414

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE---LAIKSGQVEHLQ----- 828
             L   +Q  +  +++ D  A RL E   E     EKL++E   L +KS +++ +Q     
Sbjct: 2415 TL---VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2471

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
            QET AL++     K+  LQ++  +E   ++    +QL  +  A  ++L  E +  +Q++ 
Sbjct: 2472 QETQALQQSFLSEKDSLLQRERFIE---QEKAKLEQLFQDEVAKAQQLREEQQRQQQQM- 2527

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                     E E  RL   + + R+   + E  ++  Q+E  ++E      Q  ++Q   
Sbjct: 2528 ---------EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE------QQRRQQEEL 2572

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQ---------KMRRLGSD-LTSAQKEMKTKHKA 998
            + E N+ L++Q++ L+++ R A+   ++         K    G D L     E + +H  
Sbjct: 2573 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF 2632

Query: 999  YENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSH 1056
                  + ++RLQEA  L+A+E       Q  AQG ++   LA  E ++     LQ  S 
Sbjct: 2633 DGLRRKVSAQRLQEAGILSAEEL------QRLAQGHTTVDELARREDVRHY---LQGRSS 2683

Query: 1057 SKTLLEKELQEVIAL 1071
               LL K   E +++
Sbjct: 2684 IAGLLLKATNEKLSV 2698



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 181/955 (18%), Positives = 363/955 (38%), Gaps = 94/955 (9%)

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVE-CSHSSQQRQDSLSSEVDTLK--- 474
            G+L    LE  + L+ + E    L  + TKLQ +   C     Q    L S+V  L    
Sbjct: 357  GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGK 416

Query: 475  --QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
              Q   ++ER +    +M+      + +  +      EQ  R + ++ +   ++ ++ N 
Sbjct: 417  VPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 476

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
               L+  + A  +Q+ QV     TL S  +  + E S+L+    + Q  LA  +E + R+
Sbjct: 477  --RLKAGVAAPATQVAQV-----TLQSVQRRPELEDSTLR----YLQDLLAWVEENQHRV 525

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
             G    + +  + +A L  H  L      ++      R+  ++G+++   +G   D L +
Sbjct: 526  DGAEWGVDLPSV-EAQLGSHRGLHQSI--EEFRAKIERARSDEGQLSPATRGAYRDCLGR 582

Query: 653  EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTLLQRDQQ 711
                + +Q AK +     + RL   E     +         L E++ E+V      R+  
Sbjct: 583  ----LDLQYAKLL--NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 636

Query: 712  LEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE----------- 760
            + A ++ +  LM++L L ++ ++  + + D L       +  +   Q             
Sbjct: 637  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 696

Query: 761  ----AASREDTICLLQNEKIILEA-----ALQAAKSGKEELDRGA--RRLEEGTEETSET 809
                 A  ++     Q    + EA      LQ A   K   DR A   RLE+  ++  + 
Sbjct: 697  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 756

Query: 810  LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
             E+L E      G +  L +   A+ +   +     ++ ++ + A       K   ++  
Sbjct: 757  KEQLNE----YKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV---CDYKQVEVTVH 809

Query: 870  KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
            K    +L    +    +++   G +    +    +     + ++ +  LE   Q+     
Sbjct: 810  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 869

Query: 930  DEMETHLQSL---QFDKEQMVAVTEANEALKKQIE-ELQQEARKAITEQKQKMRRLGSDL 985
             ++   ++SL   Q  +  +  +   + A  + ++ E Q++A  ++    Q   R   D 
Sbjct: 870  HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 929

Query: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
                 E +      E   G  S   Q+ L + E           QG   +S      R Q
Sbjct: 930  GGFGPEDRL---MAEREYGSCSHHYQQLLQSLE-----------QGAQEES------RCQ 969

Query: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105
               +EL+ +      L+ E  E   +    L   +E   E    + E +  + +++ L +
Sbjct: 970  RCISELKDIR-----LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1024

Query: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE--ADLVQLNLQVQAVLQRK 1163
               +L+ E E    K+  L + + A     S LE  L K E    L  + L+    +   
Sbjct: 1025 GVARLSAEAE----KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1080

Query: 1164 EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKEL 1223
                +  + +++A +  L KE + V +   ++ A K      R   +A       ++ EL
Sbjct: 1081 IRGTQGAEEVLRAHEEQL-KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1139

Query: 1224 QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
            +  + + ++LQ    +  +   +  + +AQ         AQ  + Q++L EQL +Q    
Sbjct: 1140 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL-EQLGRQLRYY 1198

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQE 1337
            +E  +      Q  R  Q   Q + L + Q  R++L   Q LL+ ++   E  +E
Sbjct: 1199 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 96/471 (20%), Positives = 187/471 (39%), Gaps = 57/471 (12%)

Query: 918  LEGHLQSAQK-----------ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            LEG +Q+ Q            E++  + H+  L+ +K Q+ +  E  E L++ + +LQ E
Sbjct: 332  LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK-QLRSEFERLECLQRIVTKLQME 390

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            A     +  Q    L SD+                A G + +R  E     + AD+ +  
Sbjct: 391  AGLCEEQLNQADALLQSDVRLL-------------AAGKVPQRAGEVERDLDKADSMIRL 437

Query: 1027 L-----RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            L       + G       ++ R+  L   L A+   +T     L+  +A  + ++ +   
Sbjct: 438  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTL 494

Query: 1082 KVLELEDELQES--RGFRKKIKRLEESNKKL--------ALELEHEKGKLTGLGQSNAAL 1131
            + ++   EL++S  R  +  +  +EE+  ++           +E + G   GL QS    
Sbjct: 495  QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF 554

Query: 1132 R---------EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
            R         E      T  A R+  L +L+LQ   +L   +   R ++ L  +  A+  
Sbjct: 555  RAKIERARSDEGQLSPATRGAYRDC-LGRLDLQYAKLLNSSKARLRSLESL-HSFVAAAT 612

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
            KE   +N  +E+      +      +  A     S + +EL+ KE  +++LQ   D L  
Sbjct: 613  KELMWLNEKEEEEVG--FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 670

Query: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
             +      +  FQA L    + +  L   ++  L +     Q   +++    Q ++  ++
Sbjct: 671  EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 730

Query: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLS-MTQKDKFMLQAK 1352
            L+++           LE L Q  Q+ K +L   +  LS + ++ K ++Q K
Sbjct: 731  LRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 781


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  185 bits (469), Expect = 3e-46
 Identities = 228/1070 (21%), Positives = 458/1070 (42%), Gaps = 119/1070 (11%)

Query: 397  ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECS 456
            E   AE +E + +V     +     EA +   +QA +E  ELQ ++     ++  + E +
Sbjct: 1379 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA 1435

Query: 457  HSSQQRQDSLSSEVDTLKQS-----------CWDLERAMTDLQNMLEAKNASLASSNNDL 505
              +QQ++ S+  E+  L+QS               ER+   ++  +      L ++    
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495

Query: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
              AE + Q L A+ E+ +            LR+Q+     + +Q ++E   L S++KA +
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE---LASRVKA-E 1551

Query: 566  AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLT 625
            AE +         ++Q AL     +RLQ E A  ++ Q      +E  +   V+L     
Sbjct: 1552 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQR 1599

Query: 626  ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA---KTMVEEDLQRRLEEFEGERE 682
              +     ++   A +   +E  + ++  A  Q++E    +   + + +R  EE E E E
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659

Query: 683  RLQRMADSAASLEQQLEQV----KLTLLQRDQQLEALQQE-------HLDLMKQLTLTQE 731
            R Q  A+ A  L  Q E+V     L   + ++Q E  ++E           ++Q  L ++
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719

Query: 732  ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
             L+ + Q  +         +  L  L+ E    E    LL+ E   L+    AA   ++E
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779

Query: 792  LDRGARRLE-----------EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
            L+    ++               EE+  T EK ++ L  ++G+   L +E A L+   ++
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1839

Query: 841  IKEQFLQQKVMVEAYRRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRT 896
             K Q  +Q    +A R+ A ++  L  +L    +ATR + ++E+  L+++  +    +R 
Sbjct: 1840 AKRQ--RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA-LKEKEAENERLRRL 1896

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE--------METHLQSLQFDKEQMVA 948
            AE E  +  R   Q  QH AD+E  L   +K  D         +E  L+  +  +E+++A
Sbjct: 1897 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1956

Query: 949  V----------------------TEANEALK-KQIEELQQEARKAITEQKQKMRRLGSDL 985
            +                      + A + L+ K+  EL+   ++ +  ++++ RR   + 
Sbjct: 1957 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016

Query: 986  T----SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG-QLRAQGGSSDSSLAL 1040
                 +A++E   + KA    V  L  +++EA   +E A+ E   QL+    ++   L  
Sbjct: 2017 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2076

Query: 1041 HER-----IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095
             E+     +Q  E ELQ     +  +  +L+       +  EE+ E  ++ E E  +SR 
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2136

Query: 1096 FRKKIKRLEESNKKLA---LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
              ++ +RL++S ++ A    + +    KL    +  AA R      + AL +++A   ++
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEM 2194

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
                +   Q   ++  Q++  +  L+  LE+   + N L E++   K EA    R     
Sbjct: 2195 EKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2253

Query: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
              EL  V+ +++    L  +++AE   L +R+  ++Q   Q +AE            KQ+
Sbjct: 2254 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK----------MKQV 2303

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
             E+ ++  V  QE   L+   ++   + ++L +++   + Q  +E   L+   + ++ + 
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
            E+AQE     Q+DK  +  +++E     +  L+  +Q +L++   A + +
Sbjct: 2364 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413



 Score =  180 bits (456), Expect = 1e-44
 Identities = 270/1151 (23%), Positives = 491/1151 (42%), Gaps = 185/1151 (16%)

Query: 366  QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
            Q  A   + Q Q+ +   R     + S V  E+ AA  ++  LQ L+E   L  Q E   
Sbjct: 1520 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---LRLQAEEAE 1576

Query: 426  LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
                QA  E+A  Q Q+A  + +  A+ E     Q ++ S + +   L++S  +   A+ 
Sbjct: 1577 RRLRQAEVERAR-QVQVALETAQRSAEAEL----QSKRASFAEKTAQLERSLQEEHVAVA 1631

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD---------- 535
             L+   E +    A +    + AE + +R   K  +  R  L  +               
Sbjct: 1632 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1691

Query: 536  -------------------LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
                               +RQ+  A Q   +Q QL   T   +L A Q E+  L++  +
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETE 1750

Query: 577  WYQQQLALAQEARVRLQGEMAHI-QVGQMTQAGLLE-HLKLENVSLSQQLTETQHRSMKE 634
              +QQ  L +E   RLQ E A   Q  Q  +A L +   ++E +  S+   E + RS  E
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810

Query: 635  KGRIAAQLQGIEADMLDQEAAFMQI--QEAKT---MVEEDLQRR---------------- 673
            K +   + +      L +EAA ++   +EAK    + EED  R+                
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870

Query: 674  ------------LEEFEGERERLQRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQ 717
                        L+E E E ERL+R+A+  A     LE+Q  Q K  + +R  QL     
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930

Query: 718  EHLDLMKQLTLTQEALQSR---EQSLDALQTHYDELQARLGELQGEA----ASREDTICL 770
              L+  +Q  L ++ L+ R   E+ + AL+  +++  A   EL+ E     ++ EDT  L
Sbjct: 1931 SELE--RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT--L 1986

Query: 771  LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
               E+  LEAA Q   + +EE     RR  E  E   ++L    E    +   +E +++ 
Sbjct: 1987 RSKEQAELEAARQRQLAAEEE-----RRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041

Query: 831  TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
             A ++ + ++++E+  Q+        ++A  K +L +E KA    +  + +EL+Q L Q 
Sbjct: 2042 KAKVE-EARRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2099

Query: 891  HG--EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                ++   EAE +R   E A+  +  A+ E     A + R ++E   +  Q  +EQ  A
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQA 2154

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR 1008
              +A  A +K  +E +QEA +    ++  +R+      +A  EM+ KHK +         
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QAADAEME-KHKKFA-------- 2201

Query: 1009 RLQEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKEL-- 1065
              ++ L  K   + EL  LR Q   +D     L E +Q L+AE    +  ++ +E+EL  
Sbjct: 2202 --EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2259

Query: 1066 -----QEVIALTSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKG 1119
                 +E+  L ++   E+R  +L  +D  Q   +   +K+K++ E   +L++  + E  
Sbjct: 2260 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAA 2318

Query: 1120 KLTGLGQSNAA---------LREH-NSILETALAKREADLVQLNLQVQAVLQRKEEEDR- 1168
            +L  L + + A         L+E   ++ E    K EA+L+Q   ++     R+ +ED+ 
Sbjct: 2319 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2378

Query: 1169 ----QMKHLVQALQASLEKEKEK-------VNSLKEQVAA---AKVEAGHNRRHFKAASL 1214
                Q+    Q  Q +LE E+++          LK +VA    A+  A  + + F+  + 
Sbjct: 2379 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438

Query: 1215 ELSEV--KKELQAKEHL-------VQKLQAEADDLQIREG-----------KHSQEIAQF 1254
            E+ E   + EL  +E +       +Q+ Q++ D  ++RE            +   ++ Q 
Sbjct: 2439 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2498

Query: 1255 QAELAEARAQLQLLQK----------QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
            ++E  +   Q QLLQ+          + D  L ++    QE   L+     +  + Q L+
Sbjct: 2499 KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR 2558

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
            ++    +QQ  +E + L   ++  +     A+E +   Q++   LQ    + +   + L 
Sbjct: 2559 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQEELLA 2615

Query: 1365 QQNQQLKLDLR 1375
            ++NQ+L+  L+
Sbjct: 2616 EENQRLREQLQ 2626



 Score =  155 bits (392), Expect = 3e-37
 Identities = 253/1169 (21%), Positives = 477/1169 (40%), Gaps = 174/1169 (14%)

Query: 393  SVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQALKEKAELQAQLA-----AL 445
            ++SL     +  EE+L+  +E+++    + A    LEA++A  +K   QA+       AL
Sbjct: 1117 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1176

Query: 446  STKLQAQVECSHSSQQRQDSLSSEVDTLKQSC------WDLERAMTDL-QNMLEAKNASL 498
              +L+   E     QQR      EV+  ++        W    A TD+ Q  LE     L
Sbjct: 1177 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1236

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
                          Q    + E +Q   L+    V   R+Q+   Q+ L++++     + 
Sbjct: 1237 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV---REQLRQEQALLEEIERHGEKVE 1293

Query: 559  SKLKASQAEISSLQSVRQWYQQQLAL--AQEARVRLQGEMAHIQVGQMTQAGLLEHLKL- 615
               + ++  I++++     Y+ QL    AQ   V    +   +Q G  +++ + E++ L 
Sbjct: 1294 ECQRFAKQYINAIKD----YELQLVTYKAQLEPVASPAKKPKVQSG--SESVIQEYVDLR 1347

Query: 616  ----ENVSLSQQ----LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVE 667
                E  +L+ Q    ++ET  R M+E+ R+A Q +  E +                   
Sbjct: 1348 THYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERE------------------- 1387

Query: 668  EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH--LDLMKQ 725
                 RL E E   E+ +++A++ A  + Q E+    L QR Q+ E +++E   +D  +Q
Sbjct: 1388 -----RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQ 1441

Query: 726  LTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR---EDTICLLQNEKIILEAAL 782
                QE LQ   QS +A      E+QA+  + +    SR   E+ I +++ +    E   
Sbjct: 1442 KRSIQEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495

Query: 783  QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
              A+   + L   A   E    +  E  E+LR ++  +S +    + E A+  K   +  
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555

Query: 843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKR-----LDSELKELRQELMQVHGE--KR 895
             +  +    +E  R  A   ++ + + +  R R     L++  +    EL        ++
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615

Query: 896  TAEAE--LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
            TA+ E  L   H  VAQ+R+           A++ R+E E  L+  Q    + + +    
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675

Query: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
            E + +Q    Q EA K   E +++ RR G     A ++ +   +  E    +     Q+ 
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735

Query: 1014 LAAKE-----AADAELGQLRAQ-------------GGSSDSSLALHERIQALEAELQAVS 1055
            LAA++      A+ E G+ + Q               ++     L   +  + AE++ + 
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1795

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR----LEESNKKLA 1111
             SK   E+E +     + Q LE    +  EL +E    R   ++ KR     EE   +  
Sbjct: 1796 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1855

Query: 1112 LELEHEKG-KLTGLG-------QSNAALREHNS-----------------ILETALAKRE 1146
             E E     KL  +G       ++  AL+E  +                  LE   A+ +
Sbjct: 1856 AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1915

Query: 1147 AD----LVQLNLQVQAVLQRKE-------EEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
            AD    L QL     + L+R++        + RQ++  + AL+AS EK       L+ ++
Sbjct: 1916 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1975

Query: 1196 AAAKVEAGHNRRHFKAASLELS--------EVKKELQAKEHLVQKLQAEADDLQIREGKH 1247
               +  A    R  + A LE +        E ++  +A+E + + L AE +  + R+   
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA- 2034

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER--EIQSLKQ 1305
             +E+ + +A++ EAR     L+++ +++ ++Q    QE    + + ++K     +Q  +Q
Sbjct: 2035 LEEVERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2090

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
            +L  T QQ +  L+ L+   +  +   E A+E     +++    + +V E +  +K   +
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAE 2149

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  Q +   +  A K RKE + EA+                A   +  LR   A   E  
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARR--------------AQAEQAALRQKQAADAEME 2195

Query: 1426 KNLNSCLQ------QLKQEMDSLQRQMEE 1448
            K+     Q      Q++QE+ +L+ Q+EE
Sbjct: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224



 Score =  117 bits (293), Expect = 8e-26
 Identities = 167/735 (22%), Positives = 311/735 (42%), Gaps = 115/735 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE-A 423
            LQ    + Q    ++ GE  + R           +A E +E  +Q  +E  +   Q+E A
Sbjct: 2092 LQQTLQQEQSVLDQLRGEAEAAR----------RAAEEAEEARVQAEREAAQSRRQVEEA 2141

Query: 424  LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL------SSEVDTLKQSC 477
              L+ S   + +A  QAQ AA   + +A+ E +  +Q  Q +L       +E++  K+  
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201

Query: 478  WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
                R    ++  L      L  +++   + +E+ QRL A+  +  R     +  +  +R
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261

Query: 538  QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
             QM  L     +++ E   L  + K          + +++ Q++     E   ++  E A
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDK---------DNTQRFLQEEA----EKMKQVAEEAA 2308

Query: 598  HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAF 656
             + V    +A  L  L  E+++  + L E   + +KEK      +Q + EA  L  EA  
Sbjct: 2309 RLSVAAQ-EAARLRQLAEEDLAQQRALAE---KMLKEK------MQAVQEATRLKAEAEL 2358

Query: 657  MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            +Q Q  K + +E  +R  E+ E   +  Q++A+     ++ LE       +R +QLE   
Sbjct: 2359 LQQQ--KELAQEQARRLQEDKE---QMAQQLAEETQGFQRTLEA------ERQRQLE--- 2404

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
                     ++   E L+ R   +   Q   +E   R  +   E   +     L   EK+
Sbjct: 2405 ---------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2455

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE---LAIKSGQVEHLQ----- 828
             L   +Q  +  +++ D  A RL E   E     EKL++E   L +KS +++ +Q     
Sbjct: 2456 TL---VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2512

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
            QET AL++     K+  LQ++  +E   ++    +QL  +  A  ++L  E +  +Q++ 
Sbjct: 2513 QETQALQQSFLSEKDSLLQRERFIE---QEKAKLEQLFQDEVAKAQQLREEQQRQQQQM- 2568

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA 948
                     E E  RL   + + R+   + E  ++  Q+E  ++E      Q  ++Q   
Sbjct: 2569 ---------EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE------QQRRQQEEL 2613

Query: 949  VTEANEALKKQIEELQQEARKAITEQKQ---------KMRRLGSD-LTSAQKEMKTKHKA 998
            + E N+ L++Q++ L+++ R A+   ++         K    G D L     E + +H  
Sbjct: 2614 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF 2673

Query: 999  YENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSH 1056
                  + ++RLQEA  L+A+E       Q  AQG ++   LA  E ++     LQ  S 
Sbjct: 2674 DGLRRKVSAQRLQEAGILSAEEL------QRLAQGHTTVDELARREDVRHY---LQGRSS 2724

Query: 1057 SKTLLEKELQEVIAL 1071
               LL K   E +++
Sbjct: 2725 IAGLLLKATNEKLSV 2739



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 181/955 (18%), Positives = 363/955 (38%), Gaps = 94/955 (9%)

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVE-CSHSSQQRQDSLSSEVDTLK--- 474
            G+L    LE  + L+ + E    L  + TKLQ +   C     Q    L S+V  L    
Sbjct: 398  GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGK 457

Query: 475  --QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
              Q   ++ER +    +M+      + +  +      EQ  R + ++ +   ++ ++ N 
Sbjct: 458  VPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 517

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
               L+  + A  +Q+ QV     TL S  +  + E S+L+    + Q  LA  +E + R+
Sbjct: 518  --RLKAGVAAPATQVAQV-----TLQSVQRRPELEDSTLR----YLQDLLAWVEENQHRV 566

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
             G    + +  + +A L  H  L      ++      R+  ++G+++   +G   D L +
Sbjct: 567  DGAEWGVDLPSV-EAQLGSHRGLHQSI--EEFRAKIERARSDEGQLSPATRGAYRDCLGR 623

Query: 653  EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTLLQRDQQ 711
                + +Q AK +     + RL   E     +         L E++ E+V      R+  
Sbjct: 624  ----LDLQYAKLL--NSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 677

Query: 712  LEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE----------- 760
            + A ++ +  LM++L L ++ ++  + + D L       +  +   Q             
Sbjct: 678  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 737

Query: 761  ----AASREDTICLLQNEKIILEA-----ALQAAKSGKEELDRGA--RRLEEGTEETSET 809
                 A  ++     Q    + EA      LQ A   K   DR A   RLE+  ++  + 
Sbjct: 738  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 797

Query: 810  LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
             E+L E      G +  L +   A+ +   +     ++ ++ + A       K   ++  
Sbjct: 798  KEQLNE----YKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV---CDYKQVEVTVH 850

Query: 870  KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
            K    +L    +    +++   G +    +    +     + ++ +  LE   Q+     
Sbjct: 851  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 910

Query: 930  DEMETHLQSL---QFDKEQMVAVTEANEALKKQIE-ELQQEARKAITEQKQKMRRLGSDL 985
             ++   ++SL   Q  +  +  +   + A  + ++ E Q++A  ++    Q   R   D 
Sbjct: 911  HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 970

Query: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
                 E +      E   G  S   Q+ L + E           QG   +S      R Q
Sbjct: 971  GGFGPEDRL---MAEREYGSCSHHYQQLLQSLE-----------QGAQEES------RCQ 1010

Query: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105
               +EL+ +      L+ E  E   +    L   +E   E    + E +  + +++ L +
Sbjct: 1011 RCISELKDIR-----LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1065

Query: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE--ADLVQLNLQVQAVLQRK 1163
               +L+ E E    K+  L + + A     S LE  L K E    L  + L+    +   
Sbjct: 1066 GVARLSAEAE----KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121

Query: 1164 EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKEL 1223
                +  + +++A +  L KE + V +   ++ A K      R   +A       ++ EL
Sbjct: 1122 IRGTQGAEEVLRAHEEQL-KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1180

Query: 1224 QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
            +  + + ++LQ    +  +   +  + +AQ         AQ  + Q++L EQL +Q    
Sbjct: 1181 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL-EQLGRQLRYY 1239

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKELEGLQQLLQNVKSELEMAQE 1337
            +E  +      Q  R  Q   Q + L + Q  R++L   Q LL+ ++   E  +E
Sbjct: 1240 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 96/471 (20%), Positives = 187/471 (39%), Gaps = 57/471 (12%)

Query: 918  LEGHLQSAQK-----------ERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
            LEG +Q+ Q            E++  + H+  L+ +K Q+ +  E  E L++ + +LQ E
Sbjct: 373  LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK-QLRSEFERLECLQRIVTKLQME 431

Query: 967  ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            A     +  Q    L SD+                A G + +R  E     + AD+ +  
Sbjct: 432  AGLCEEQLNQADALLQSDVRLL-------------AAGKVPQRAGEVERDLDKADSMIRL 478

Query: 1027 L-----RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            L       + G       ++ R+  L   L A+   +T     L+  +A  + ++ +   
Sbjct: 479  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTL 535

Query: 1082 KVLELEDELQES--RGFRKKIKRLEESNKKL--------ALELEHEKGKLTGLGQSNAAL 1131
            + ++   EL++S  R  +  +  +EE+  ++           +E + G   GL QS    
Sbjct: 536  QSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF 595

Query: 1132 R---------EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
            R         E      T  A R+  L +L+LQ   +L   +   R ++ L  +  A+  
Sbjct: 596  RAKIERARSDEGQLSPATRGAYRDC-LGRLDLQYAKLLNSSKARLRSLESL-HSFVAAAT 653

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI 1242
            KE   +N  +E+      +      +  A     S + +EL+ KE  +++LQ   D L  
Sbjct: 654  KELMWLNEKEEEEVG--FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 711

Query: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
             +      +  FQA L    + +  L   ++  L +     Q   +++    Q ++  ++
Sbjct: 712  EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 771

Query: 1303 LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLS-MTQKDKFMLQAK 1352
            L+++           LE L Q  Q+ K +L   +  LS + ++ K ++Q K
Sbjct: 772  LRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 822


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  181 bits (460), Expect = 4e-45
 Identities = 219/1085 (20%), Positives = 465/1085 (42%), Gaps = 94/1085 (8%)

Query: 332  LSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEH------QDQGQEVNGEVRS 385
            L K  G Q      +G  +  D+  +  S++  L+ A  E+      +D  ++   ++ +
Sbjct: 113  LEKYQGLQQQEAKPDG--LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLAT 170

Query: 386  RRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ-LEALSLEASQ--ALKEKAELQAQL 442
                I S    E S  E  E+ +  L E++  E   ++ L  E  Q   +++ A L+ +L
Sbjct: 171  EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKEL 230

Query: 443  AALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSN 502
              + T +      +   ++  + L  E   L+      E  ++ L++ L      +A   
Sbjct: 231  VQVQTLMD---NMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287

Query: 503  NDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTA-------LQSQLQQVQLERT 555
             +LQ  +     L  K + +  ++L K+     L ++          +Q+ L Q  L+  
Sbjct: 288  QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347

Query: 556  TLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKL 615
             L S+L AS+  +  +         +L+   EA  +L+ E++ ++          +HLK 
Sbjct: 348  QLQSRLSASETSLHRIHV-------ELSEKGEATQKLKEELSEVETKY-------QHLKA 393

Query: 616  ENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLE 675
            E   L QQ  E +   ++    + +++  + + +L+ E    Q+ EA   ++E  Q   E
Sbjct: 394  EFKQLQQQREEKEQHGLQ----LQSEINQLHSKLLETER---QLGEAHGRLKEQRQLSSE 446

Query: 676  EFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQS 735
            +   + +++  +    + LE+QL++      +   QL+  +Q+H +       T   L+ 
Sbjct: 447  KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506

Query: 736  REQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRG 795
             +  L+ +     +   ++  L+      ++ I LL+ E+  L A +QA +     L++ 
Sbjct: 507  AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566

Query: 796  ARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAY 855
              +     E+ ++  EKL+ +        E+L  +    K  ++  +++ L  +  V   
Sbjct: 567  QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626

Query: 856  RRDATSKDQLISEL----KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQV 911
                    + +S+L    KA  + L S       +   +     TA+  L    +E+ ++
Sbjct: 627  NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686

Query: 912  RQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEAR--K 969
               +  +   LQ  Q+   ++E+HL+     KE+ +++ +  E L+ QI++L+ ++   K
Sbjct: 687  TTQLDQVTAKLQDKQEHCSQLESHLKEY---KEKYLSLEQKTEELEGQIKKLEADSLEVK 743

Query: 970  AITEQK----QKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG 1025
            A  EQ     Q+ R+L +DL     E+  + +  +  V      LQ+   A E+   +L 
Sbjct: 744  ASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803

Query: 1026 QLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE 1085
            +               E  Q L+ + + +S    +  +EL   I  T  EL++ +   +E
Sbjct: 804  K-------------QEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK---ME 847

Query: 1086 LEDELQESRGFRKKIKRLEES--NKKLALELEHEKGK--LTGLGQSNAALREHNSI-LET 1140
             E  + E    + K+ ++ +S  N K   E E++KGK  +  L ++   L+    + +E 
Sbjct: 848  KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907

Query: 1141 ALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEK------VNSLKEQ 1194
             L +++     L  + +A  Q K E +   + L+QA     + EKE+      +N LK+ 
Sbjct: 908  TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967

Query: 1195 VAAAKVEAGHNRRHFKAASLELSEVKKELQAK-EHLVQKLQAEADDLQIREG---KHSQE 1250
                K +    +   K A L+ +E++ +LQ +     Q+L AE + + + +    K  + 
Sbjct: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027

Query: 1251 IAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLT 1310
              Q Q++     ++L   ++ L     K  +  +++ + + ++  + + IQ LK      
Sbjct: 1028 FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087

Query: 1311 EQQGRKELEGLQQ---LLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELK-NNMKTLLQQ 1366
            EQ   K+ + LQ+    LQ+++ E  + +++L + +K K    A++ E+K    K + + 
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKEL-VNEKSKL---AEIEEIKCRQEKEITKL 1143

Query: 1367 NQQLK 1371
            N++LK
Sbjct: 1144 NEELK 1148



 Score =  178 bits (451), Expect = 4e-44
 Identities = 276/1362 (20%), Positives = 554/1362 (40%), Gaps = 186/1362 (13%)

Query: 149  QVRLQARKWLEEQLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPRASTLAMTK 208
            Q  L+  KW  E+LK+  +++ Q    Q A    L +    EL    ++L +    A T+
Sbjct: 96   QASLKEEKWYSEELKK-ELEKYQGLQQQEAKPDGLVTDSSAEL----QSLEQQLEEAQTE 150

Query: 209  EYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRSLADYR-TEDSNAGNSGGNVPAPD 267
             ++  +       K   L       + K  +   +R  A+ + T  +   N    V    
Sbjct: 151  NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL 210

Query: 268  STKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSSYSSASTRG 327
             T+   +      A +  E+         ++N +L  +  SE   ++        AS+  
Sbjct: 211  KTELLQRPGIEDVAVLKKELV---QVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 267

Query: 328  TYGILSKTV--GTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRS 385
            T   L   +  G Q+    V   +    ++ +       L     + +    ++  E + 
Sbjct: 268  TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL--EEKH 325

Query: 386  RRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAAL 445
              +S+ S  +++++  +   +  Q+       E  L  + +E S+  +   +L+ +L+ +
Sbjct: 326  NEESV-SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV 384

Query: 446  STKLQ-AQVECSHSSQQRQDS------LSSEVDTLKQSCWDLERAMTDLQNMLEAKNASL 498
             TK Q  + E     QQR++       L SE++ L     + ER + +    L+ +    
Sbjct: 385  ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQL- 443

Query: 499  ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
              S+  L   E+Q   L  K+  ++  +  K     +L+ Q+   + Q Q+ Q  + + T
Sbjct: 444  --SSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501

Query: 559  SKLKASQAE--------------ISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQM 604
            +KL+ +Q +              I +L+++ Q  ++ ++L ++ R  L    A IQ G+ 
Sbjct: 502  AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLY---AKIQAGE- 557

Query: 605  TQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKT 664
             +  +L  L+ +N +L +Q+T+   +   +           E+    QE    Q+QE K 
Sbjct: 558  GETAVLNQLQEKNHTLQEQVTQLTEKLKNQS----------ESHKQAQENLHDQVQEQKA 607

Query: 665  MVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQ------- 717
                            ++R+  +  S   L  QL + K  + Q D Q++A  +       
Sbjct: 608  -----------HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656

Query: 718  ----EHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQN 773
                +  DL   L   Q ALQ ++Q L+ + T  D++ A+L + Q   +  E  +   + 
Sbjct: 657  AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716

Query: 774  EKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAA 833
            + + LE          EEL+   ++LE  + E   + E+  ++L  +      L+     
Sbjct: 717  KYLSLEQKT-------EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769

Query: 834  LKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGE 893
            L KQ++  KE       +V + R D   K + +  +K    + + E + L+Q+   +  E
Sbjct: 770  LSKQLEMEKE-------IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822

Query: 894  KRTAEAELS-RLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSL-----QFDKEQM- 946
             +    EL+ R+   V ++++   + E  +      +D++     SL     +F+KE   
Sbjct: 823  TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882

Query: 947  --VAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVG 1004
               A+ +  +  K+   +LQ +    + EQK+  + L       +KE   + K   N++ 
Sbjct: 883  GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL-----EKEKEASHQLKLELNSMQ 937

Query: 1005 ILSRRLQEALAAKEAADAEL-GQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEK 1063
                + Q  L   E  + +L G +     SS+      ++I+AL+ EL+     KT LE 
Sbjct: 938  EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK---KKQIEALQGELKIAVLQKTELEN 994

Query: 1064 ELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTG 1123
            +LQ+ +   +QEL   +EK+  L++  ++S          +E+ K+L  +    + +L  
Sbjct: 995  KLQQQLTQAAQELAAEKEKISVLQNNYEKS----------QETFKQLQSDFYGRESELLA 1044

Query: 1124 LGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKE-------EEDRQMKHLVQA 1176
              Q   ++ E  S+ +  L      +   N  +Q +   K        ++++Q++   +A
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104

Query: 1177 LQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAE 1236
            LQ  ++KEK    SLKE+                    EL   K +L   E +  + + E
Sbjct: 1105 LQ-DIQKEK----SLKEK--------------------ELVNEKSKLAEIEEIKCRQEKE 1139

Query: 1237 ADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQK 1296
               L      H  E  +    L +A+ QL L+Q++L+ Q         + ++LK  V+Q+
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAK-QL-LIQQKLELQ--------GKADSLKAAVEQE 1189

Query: 1297 EREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSEL 1356
            +R  Q LK Q+   E++ +KE    +  L    SE++  +  +   ++++  L  +++ L
Sbjct: 1190 KRNQQILKDQVKKEEEELKKEFIEKEAKLH---SEIKEKEVGMKKHEENEAKLTMQITAL 1246

Query: 1357 KNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVP------ASLL 1410
              N+ T+ ++ Q          +  R+  + E  + +    I + +  V        +LL
Sbjct: 1247 NENLGTVKKEWQ----------SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALL 1296

Query: 1411 EELLRPPPAVSK---------EPLKNLNSCLQQLKQEMDSLQ 1443
            E  L+    + K           L N  + +Q+L +E  SLQ
Sbjct: 1297 ERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338



 Score =  160 bits (404), Expect = 1e-38
 Identities = 215/964 (22%), Positives = 413/964 (42%), Gaps = 139/964 (14%)

Query: 544  QSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQ 603
            +S L   + + T L  +++  QA +       +WY ++L    E   + QG    +Q  +
Sbjct: 75   ESNLALKRDDVTLLRQEVQDLQASLKE----EKWYSEELKKELE---KYQG----LQQQE 123

Query: 604  MTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAK 663
                GL+     E  SL QQL E Q  +   K     Q++    D+ +Q+AA +  + A 
Sbjct: 124  AKPDGLVTDSSAELQSLEQQLEEAQTENFNIK-----QMK----DLFEQKAAQLATEIAD 174

Query: 664  TMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRD--QQLEALQQEHLD 721
               + D +R L E     +++ R+ +        ++ +K  LLQR   + +  L++E + 
Sbjct: 175  IKSKYDEERSLRE--AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ 232

Query: 722  ---LMKQLTLTQEALQSR-EQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKII 777
               LM  +TL +E    + +     LQ+ Y   +A + +L+ E A     + +   E   
Sbjct: 233  VQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQE--- 289

Query: 778  LEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQ 837
                LQ  KS   EL +  + L E   +  +   KL E+   +S   +++Q         
Sbjct: 290  ----LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD 345

Query: 838  MQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTA 897
             Q+++ +    +  +     + + K +   +LK     ++++ + L+ E  Q+  ++   
Sbjct: 346  CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEK 405

Query: 898  EAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALK 957
            E    +L  E+ Q+   + + E  L  A     E          DKEQ VA       L+
Sbjct: 406  EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVA------DLQ 459

Query: 958  KQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAK 1017
             ++  L+++ ++ +T   +   +L           KTK +  E       + LQ++  AK
Sbjct: 460  LKLSRLEEQLKEKVTNSTELQHQLD----------KTKQQHQEQ------QALQQSTTAK 503

Query: 1018 -EAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALT---- 1072
               A  +L Q+  Q G  D      ++IQ LEA LQ    + +LLEKE +++ A      
Sbjct: 504  LREAQNDLEQVLRQIGDKD------QKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 557

Query: 1073 --SQELEESREKVLELEDELQESRGFRKKIKRLEESNKK----LALELEHEKGKLTGLGQ 1126
              +  L + +EK   L++++ +     +K+K   ES+K+    L  +++ +K  L     
Sbjct: 558  GETAVLNQLQEKNHTLQEQVTQ---LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD 614

Query: 1127 SNAALREHNSILETALAKREADLVQLNLQVQAVLQ-------RKEEEDRQMKHLVQALQA 1179
               +L    + L + L + +  + QL++Q++A  +        K  +   +++ +   Q 
Sbjct: 615  RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674

Query: 1180 SLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQA---- 1235
            +L+ +++++N +  Q+     +    + H       L E K++  + E   ++L+     
Sbjct: 675  ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734

Query: 1236 -EADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLS--KQPVGN--------- 1283
             EAD L+++  K  ++  Q   +  +    L+L   +L +QL   K+ V +         
Sbjct: 735  LEADSLEVKASK--EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792

Query: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQL-------LQNVKSELEMAQ 1336
            + +E++K ++ ++E E Q LKQ  +   Q+ + + E L          LQ VK E E   
Sbjct: 793  EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852

Query: 1337 EDLSMTQKDKFMLQAKVSE-LKNNMKTLLQQNQQLK---LDLRRGAAKTRKEPKGEASSS 1392
             +LS T KDK    +KVS+ LKN+     ++NQ+ K   LDL     KT KE K +    
Sbjct: 853  TELS-TVKDKL---SKVSDSLKNSKSEFEKENQKGKAAILDLE----KTCKELKHQLQVQ 904

Query: 1393 NPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALT 1452
                             +E  L+    + K  L+       QLK E++S+Q Q+ +   T
Sbjct: 905  -----------------MENTLKEQKELKKS-LEKEKEASHQLKLELNSMQEQLIQAQNT 946

Query: 1453 VHES 1456
            + ++
Sbjct: 947  LKQN 950



 Score =  154 bits (390), Expect = 5e-37
 Identities = 230/1042 (22%), Positives = 459/1042 (44%), Gaps = 142/1042 (13%)

Query: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ 420
            +K+ L     ++Q    E     + R +     + L+S   +   ++L+  ++     G+
Sbjct: 377  LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR 436

Query: 421  LEALSLEASQALKEK----AELQAQLAAL----------STKLQAQVECSHSSQQRQDSL 466
            L+     +S+ L +K    A+LQ +L+ L          ST+LQ Q++ +    Q Q +L
Sbjct: 437  LKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 496

Query: 467  S-SEVDTLKQSCWDLE---RAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVE-- 520
              S    L+++  DLE   R + D    ++   A L  S  ++ + E++ + L AK++  
Sbjct: 497  QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAG 556

Query: 521  DMQRSMLSK-DNTVHDLRQQMTALQSQLQ---------------QVQLERTTLTSKLKAS 564
            + + ++L++     H L++Q+T L  +L+               QVQ ++    + L+A+
Sbjct: 557  EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK----AHLRAA 612

Query: 565  QAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGL-LEHLKLENVSLSQQ 623
            Q  + SL++       QL  ++E   +L      IQ+   T+  L  E  K    +  Q 
Sbjct: 613  QDRVLSLETSVNELNSQLNESKEKVSQLD-----IQIKAKTELLLSAEAAKTAQRADLQN 667

Query: 624  LTETQHRSMKEK----GRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEE---DLQRRLEE 676
              +T   ++++K     +I  QL  + A + D++    Q++      +E    L+++ EE
Sbjct: 668  HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727

Query: 677  FEGERERLQRMADSA---ASLEQQLEQVKLTLLQRDQQLEA-LQQEHLDLMKQLTLTQEA 732
             EG+ ++L+  ADS    AS EQ L+      LQ+ +QL   L+    +L KQL + +E 
Sbjct: 728  LEGQIKKLE--ADSLEVKASKEQALQD-----LQQQRQLNTDLELRATELSKQLEMEKEI 780

Query: 733  LQSREQSLDALQTHYDELQARLGELQGEAAS-REDTICLLQNEKIILE----------AA 781
            + S    L       + ++ +L + + E    ++D   L Q  KI  E            
Sbjct: 781  VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840

Query: 782  LQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQ----VEHLQQETAALKKQ 837
            LQ  K  KE L      +++   + S++L+  + E   ++ +    +  L++    LK Q
Sbjct: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900

Query: 838  MQKIKEQFL-QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRT 896
            +Q   E  L +QK + ++  ++  +  QL  EL +    +  +L + +  L Q   E++ 
Sbjct: 901  LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS----MQEQLIQAQNTLKQNEKEEQQ 956

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQS--------LQFDKEQMVA 948
             +  ++ L +   Q ++ +  L+G L+ A  ++ E+E  LQ         L  +KE++  
Sbjct: 957  LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV 1016

Query: 949  VTEANEALKKQIEELQQE---ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGI 1005
            +    E  ++  ++LQ +       +   +Q ++ +   L+ AQ+++ +      N +G 
Sbjct: 1017 LQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR----NQIGN 1072

Query: 1006 LSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKEL 1065
             ++ +QE   AK   + +  +   Q         L ER +AL    Q +   K+L EKEL
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQ---------LQERCKAL----QDIQKEKSLKEKEL 1119

Query: 1066 QEVIALTSQELEESR----EKVLELEDELQESR-GFRKKIKRLEESNKKLALELEHEKGK 1120
                +  + E+EE +    +++ +L +EL+  +    K+I  L+++ + L  +    +GK
Sbjct: 1120 VNEKSKLA-EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178

Query: 1121 LTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR--KEEEDRQMKHLVQALQ 1178
               L  +    + +  IL+  + K E +L +  ++ +A L    KE+E    KH     +
Sbjct: 1179 ADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK 1238

Query: 1179 ASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEAD 1238
             +++     + +L E +   K E   ++R       +  +++ E+   E  VQ  Q E  
Sbjct: 1239 LTMQ-----ITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293

Query: 1239 DLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSK-QPVG--NQEME-------N 1288
             L  R  K   EI + Q ++ E       LQ++LD   +  Q +G  NQ ++       N
Sbjct: 1294 ALLERCLKGEGEIEKLQTKVLE-------LQRKLDNTTAAVQELGRENQSLQIKHTQALN 1346

Query: 1289 LKWEVDQKEREIQSLKQQLDLT 1310
             KW  D + +   +  +   +T
Sbjct: 1347 RKWAEDNEVQNCMACGKGFSVT 1368



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 135/703 (19%), Positives = 296/703 (42%), Gaps = 100/703 (14%)

Query: 357  QFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVS--------LESSAAETQEEML 408
            Q   +++ L  A    QD+ QE+N ++ ++ D + + +         LES   E +E+ L
Sbjct: 661  QRADLQNHLDTAQNALQDKQQELN-KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719

Query: 409  QVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSS 468
             + ++   LEGQ++ L  ++   L+ KA  +  L  L  + Q   +    + +    L  
Sbjct: 720  SLEQKTEELEGQIKKLEADS---LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 776

Query: 469  EVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKV----EDMQR 524
            E + +  +  DL++        LE+    L     + Q+ ++ ++ L  +     E++  
Sbjct: 777  EKEIVSSTRLDLQKK----SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832

Query: 525  SMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAE-----------ISSLQS 573
             + +    +  ++ +  AL ++L  V+ + + ++  LK S++E           I  L+ 
Sbjct: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892

Query: 574  VRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMK 633
              +  + QL +  E  ++ Q E+      +   +     LKLE  S+ +QL + Q+ ++K
Sbjct: 893  TCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS---HQLKLELNSMQEQLIQAQN-TLK 948

Query: 634  EKGRIAAQLQG---------------IEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFE 678
            +  +   QLQG               IEA   + + A +Q  E +  +++ L +  +E  
Sbjct: 949  QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA 1008

Query: 679  GERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQE------- 731
             E+E++  + ++    ++  +Q++     R+ +L A +Q+   + ++L+L QE       
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN 1068

Query: 732  ----------------------------ALQSREQSLDALQTHYDELQARLGELQGEAAS 763
                                         LQ R ++L  +Q      +  L   + + A 
Sbjct: 1069 QIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE 1128

Query: 764  REDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQ 823
             E+  C  + E   L   L   KS K E  +    L++  +   +   +L+ +       
Sbjct: 1129 IEEIKCRQEKEITKLNEEL---KSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAA 1185

Query: 824  VEHLQQETAALKKQMQKIKEQFLQQKVMVEA-YRRDATSKDQLISELKATRKRLDSELKE 882
            VE  ++    LK Q++K +E+  ++ +  EA    +   K+  + + +    +L  ++  
Sbjct: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245

Query: 883  LRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEM-------ETH 935
            L + L  V  E ++++  +S L ++   +R  +A LE  +Q+ Q ER  +       E  
Sbjct: 1246 LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE 1305

Query: 936  LQSLQFD----KEQMVAVTEANEALKKQIEELQQEARKAITEQ 974
            ++ LQ      + ++   T A + L ++ + LQ +  +A+  +
Sbjct: 1306 IEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRK 1348


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  179 bits (454), Expect = 2e-44
 Identities = 228/1061 (21%), Positives = 446/1061 (42%), Gaps = 140/1061 (13%)

Query: 371  EHQDQGQEVNGEVRSRRDSI---CSSVS-----LESSAAETQEEMLQVLKEKMRLEGQLE 422
            E  ++ +E+N E+ +++ ++   CSS+      LE +  + ++E      +   L  ++ 
Sbjct: 928  ERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMT 987

Query: 423  ALSLEASQALKEKAELQA-------QLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQ 475
            AL    S+  KEK  LQ         L     K+   ++ +   +Q+ D L   ++  K+
Sbjct: 988  ALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKK 1047

Query: 476  SCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQR-------LMAKVEDMQRSMLS 528
               DLERA   L+  L+    S+    ND Q  EE+ ++       L AK++D Q   L 
Sbjct: 1048 LRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQ 1107

Query: 529  KDNTVHDLRQQMTALQSQLQ-------QVQLERTTLTSKLK-----------ASQAEISS 570
                + +L+ ++  L+ +++       +++ +R+ L  +L+           A+ A+I  
Sbjct: 1108 FQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEM 1167

Query: 571  LQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHR 630
             +     +Q+     +EA ++ +   A ++  Q      L   +++N+   +Q  E +  
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGE-QIDNLQRVKQKLEKEKS 1226

Query: 631  SMK-EKGRIAAQLQ-------GIEADMLDQEAAFMQIQ---EAKTMVEEDLQRRLEEFEG 679
             +K E   +A+ ++        IE      E  F +I+   E +T +  DL  +    + 
Sbjct: 1227 ELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQT 1286

Query: 680  ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQS 739
            +   L    +   SL  QL + K  L    QQLE L+++  +  K       ALQS    
Sbjct: 1287 QNGELSHRVEEKESLISQLTKSKQAL---TQQLEELKRQMEEETKAKNAMAHALQSSRHD 1343

Query: 740  LDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRL 799
             D L+  Y+E Q    ELQ  A S+ ++       K   +A  +      EEL+   ++L
Sbjct: 1344 CDLLREQYEEEQEAKAELQ-RALSKANSEVAQWRTKYETDAIQRT-----EELEEAKKKL 1397

Query: 800  EEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKI--------KEQFLQQKVM 851
             +  +E  E  E    + A      + LQ E   L + +++         K+Q    KV+
Sbjct: 1398 AQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVL 1457

Query: 852  VEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQV 911
             E  ++   S+ +L +  K +R  L +EL ++R    +V  +  T   E   L  E++ +
Sbjct: 1458 AEWKQKLDESQAELEAAQKESRS-LSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDL 1516

Query: 912  RQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAI 971
             + +A+   +LQ A+K +  +E     LQ   E++    E  E+   +I  +Q E  +  
Sbjct: 1517 TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEES---KILRVQLELSQVK 1573

Query: 972  TEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQG 1031
            +E  +K+     ++   ++  +   +A ++ +    R   +AL  K+  + +L ++  Q 
Sbjct: 1574 SELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQL 1633

Query: 1032 GSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQ 1091
            G S+  +A                        E Q+ +     +L++S+   L L+D L+
Sbjct: 1634 GHSNRQMA------------------------ETQKHLRTVQGQLKDSQ---LHLDDALR 1666

Query: 1092 ESRGFRKKIKRLEESNKKLALELEHEK--------------GKLTGLGQSNAALREHNSI 1137
             +   ++++  +E  N  L  ELE  K               +L         L   N+ 
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726

Query: 1138 LETALAKREADLVQLNLQVQ-AVLQRKEEEDRQMKHLVQALQASLEKEKEKVNS-----L 1191
            L     K EAD+ Q   +V+ ++ + +  E++  K +  A   + E +KE+  S     +
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786

Query: 1192 KEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEI 1251
            K+ +     +  H  R  +A  L L   KK++Q  E+ V++L+ E D  Q R        
Sbjct: 1787 KKNLEQTVKDLQH--RLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRG------- 1837

Query: 1252 AQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTE 1311
                   AEA       ++++ E   +    ++ +  L+  VD+ + +++S K+Q +  E
Sbjct: 1838 -------AEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAE 1890

Query: 1312 QQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAK 1352
            +Q   +L   ++    V+ ELE A E   + +     L+AK
Sbjct: 1891 EQANTQLSRCRR----VQHELEEAAERADIAESQVNKLRAK 1927



 Score =  172 bits (435), Expect = 3e-42
 Identities = 236/1128 (20%), Positives = 495/1128 (43%), Gaps = 164/1128 (14%)

Query: 358  FPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL 417
            F  IK +L++A AE +    + + E R++ +   S    E+   E +E+M+ +L+EK  L
Sbjct: 837  FFKIKPLLKSAEAEKEMATMKEDFE-RTKEELARS----EARRKELEEKMVSLLQEKNDL 891

Query: 418  EGQLEALSLEASQA-------LKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEV 470
            + Q+++ +     A       +K K  L+A++  L+ +L+ + E +     ++ +L  + 
Sbjct: 892  QLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKC 951

Query: 471  DTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKD 530
             +LK+   DLE  +T ++    A    + + + ++   EE   +L  + + +Q +     
Sbjct: 952  SSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEA---HQ 1008

Query: 531  NTVHDLR-----------------QQMTALQSQLQQ-----VQLERTT--LTSKLKASQA 566
             T+ DL+                 QQ   L+  L+Q       LER    L   LK SQ 
Sbjct: 1009 QTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE 1068

Query: 567  EISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTE 626
             I  L++ +Q  +++L   +    +LQ ++   QV  +     ++ L+     L +++ E
Sbjct: 1069 SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI-E 1127

Query: 627  TQH----RSMKEKGRIAAQLQGIEADMLDQEAAF---MQIQEAKTMVEEDLQRRLEEFEG 679
             +H    +  K++  +A +L+ I   + +   A    +++ + +    + ++R LEE   
Sbjct: 1128 AEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATL 1187

Query: 680  ERERL-----QRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQ 734
            + E       ++ ADS A L +Q++ ++    + +++   L+ E  D+   +    ++  
Sbjct: 1188 QHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247

Query: 735  SREQSLDALQTHYDE---------------------LQARLGELQGEAASREDTICLLQN 773
            + E++   ++  + E                     LQ + GEL      +E  I  L  
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307

Query: 774  EKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQ---- 829
             K  L   L+  K   EE  +    +    + +    + LRE+   +      LQ+    
Sbjct: 1308 SKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSK 1367

Query: 830  ------------ETAALKK--QMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKR 875
                        ET A+++  ++++ K++  Q+    E     A SK    + L+ T++R
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSK---CASLEKTKQR 1424

Query: 876  LDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETH 935
            L  E+++L ++L + H    T + +     + +A+ +Q + + +  L++AQKE   + T 
Sbjct: 1425 LQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTE 1484

Query: 936  LQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTK 995
            L  ++   E++V   +  E L+++ + LQ+E    I++  +++   G +L  A+K   TK
Sbjct: 1485 LFKMRNAYEEVV---DQLETLRRENKNLQEE----ISDLTEQIAETGKNLQEAEK---TK 1534

Query: 996  HKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVS 1055
             K  E     L   L+E   + E  ++++  LR Q   S     L  ++   + E++ + 
Sbjct: 1535 -KLVEQEKSDLQVALEEVEGSLEHEESKI--LRVQLELSQVKSELDRKVIEKDEEIEQLK 1591

Query: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELE 1115
             +     + LQ V+    +   ++     ++E +L E         +L  SN+++A   E
Sbjct: 1592 RNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEME------IQLGHSNRQMA---E 1642

Query: 1116 HEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKE----EEDRQMK 1171
             +K   T  GQ    L++    L+ AL   E    QL     A+++R+     EE  +MK
Sbjct: 1643 TQKHLRTVQGQ----LKDSQLHLDDALRSNEDLKEQL-----AIVERRNGLLLEELEEMK 1693

Query: 1172 HLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQ 1231
              ++        + E+   L EQ     ++A    +   + +  L   KK+L+A    + 
Sbjct: 1694 VALE--------QTERTRRLSEQEL---LDASDRVQLLHSQNTSLINTKKKLEAD---IA 1739

Query: 1232 KLQAEADDLQIREGKHSQEIAQFQ----AELAE-------ARAQLQLLQKQLDEQLSKQP 1280
            + QAE ++  I+E ++++E A+      A +AE         A L+ ++K L++ +    
Sbjct: 1740 QCQAEVEN-SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1798

Query: 1281 VGNQEMENL-----KWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMA 1335
                E E L     K ++ + E  ++ L+ +LD+ +++G + L+G  +  + VK     A
Sbjct: 1799 HRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQA 1858

Query: 1336 QEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRK 1383
            +ED     K+   LQ  V +L+  +K+  +Q ++ +       ++ R+
Sbjct: 1859 EED----HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRR 1902



 Score =  157 bits (397), Expect = 7e-38
 Identities = 179/815 (21%), Positives = 371/815 (45%), Gaps = 121/815 (14%)

Query: 660  QEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKL-------TLLQRDQQL 712
            +E  TM +ED +R  EE      R + + +   SL Q+   ++L        L+  +++ 
Sbjct: 851  KEMATM-KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909

Query: 713  EALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQ 772
            E L +  + L  ++    E L+  E+    L      L+ +   L+ +    E T+  ++
Sbjct: 910  EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVE 969

Query: 773  NEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETA 832
             EK   E  ++        L+    +L +  +   E  ++  ++L ++  +V  L +  A
Sbjct: 970  KEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINA 1029

Query: 833  ALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHG 892
             L++Q   ++    Q+K              +L ++L+  +++L+ +LK  ++ +M +  
Sbjct: 1030 KLEQQTDDLEGSLEQEK--------------KLRADLERAKRKLEGDLKMSQESIMDLEN 1075

Query: 893  EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEA 952
            +K+  E +L +   E++Q++  + D + H    QK+  E++  ++ L+ +        EA
Sbjct: 1076 DKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEE-------IEA 1128

Query: 953  NEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQE 1012
               L+ +IE+ + +  + + E  +++    S  TSAQ EM  K +A       + R L+E
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEE-ASGATSAQIEMNKKREAEFQK---MRRDLEE 1184

Query: 1013 ALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALT 1072
            A    EA  A L + +A     DS   L E+I  L+   Q +   K+ L+ E+ + +A  
Sbjct: 1185 ATLQHEATAATLRKKQA-----DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDD-MASN 1238

Query: 1073 SQELEESREKV----LELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKL-TGLGQS 1127
             + L +S+  +      +ED+  E       IK  +E   +L  +L  +K +L T  G+ 
Sbjct: 1239 IEALSKSKSNIERTCRTVEDQFSE-------IKAKDEQQTQLIHDLNMQKARLQTQNGEL 1291

Query: 1128 NAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQAS------- 1180
            +  + E  S++      ++A    L  Q++ + ++ EEE +    +  ALQ+S       
Sbjct: 1292 SHRVEEKESLISQLTKSKQA----LTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLL 1347

Query: 1181 ---LEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASL----ELSEVKKELQAK------- 1226
                E+E+E    L+  ++ A  E    R  ++  ++    EL E KK+L  +       
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407

Query: 1227 -----------EHLVQKLQAEADD--------------LQIREGKHSQEIAQFQAELAEA 1261
                       E   Q+LQ E +D              L  ++    + +A+++ +L E+
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467

Query: 1262 RAQLQLLQKQ---LDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQL-DLTEQ----- 1312
            +A+L+  QK+   L  +L K     +E+ +   +++   RE ++L++++ DLTEQ     
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVD---QLETLRRENKNLQEEISDLTEQIAETG 1524

Query: 1313 QGRKELEGLQQLLQNVKSELEMAQEDL--SMTQKDKFML--QAKVSELKNNMKTLL---- 1364
            +  +E E  ++L++  KS+L++A E++  S+  ++  +L  Q ++S++K+ +   +    
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKD 1584

Query: 1365 QQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIK 1399
            ++ +QLK + +R A   +     E  S N A  +K
Sbjct: 1585 EEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLK 1619



 Score =  152 bits (385), Expect = 2e-36
 Identities = 212/1052 (20%), Positives = 450/1052 (42%), Gaps = 160/1052 (15%)

Query: 478  WDLERAMTDLQNMLEAKNAS--LASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD 535
            W        ++ +L++  A   +A+   D +  +E+  R  A+ ++++  M+S     +D
Sbjct: 831  WPWMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKND 890

Query: 536  LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE 595
            L+ Q+ +    L   +     L       +A++  L        ++L   +E    L  +
Sbjct: 891  LQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELT-------ERLEEEEEMNSELVAK 943

Query: 596  MAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAA 655
              +++            LK +   L   LT+ +    KEK     +++ +  +M   E  
Sbjct: 944  KRNLE-------DKCSSLKRDIDDLELTLTKVE----KEKHATENKVKNLSEEMTALEEN 992

Query: 656  FMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEAL 715
              ++ + K  ++E  Q+ L++ + E +++  +    A LEQQ + ++ +L Q  +    L
Sbjct: 993  ISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADL 1052

Query: 716  QQEHLDLMKQLTLTQEAL-------QSREQSLDALQTHYDELQARLGELQGEAASREDTI 768
            ++    L   L ++QE++       Q  E+ L   +    +LQA++ + Q  +   +  I
Sbjct: 1053 ERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKI 1112

Query: 769  CLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQ 828
              LQ     LE  ++A  + + ++++    L    EE SE LE   E     S Q+E  +
Sbjct: 1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE---EASGATSAQIEMNK 1169

Query: 829  QETAALKKQMQKIKEQFLQQKVMVEAYR-RDATSKDQL---ISELKATRKRLDSELKELR 884
            +  A  +K  + ++E  LQ +      R + A S  +L   I  L+  +++L+ E  EL+
Sbjct: 1170 KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK 1229

Query: 885  QEL--------------MQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERD 930
             E+                +    RT E + S +  +  Q  Q + DL       Q +  
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNG 1289

Query: 931  EMETHLQSLQFDKEQMVA-VTEANEALKKQIEELQQE------ARKAIT----------- 972
            E+   ++    +KE +++ +T++ +AL +Q+EEL+++      A+ A+            
Sbjct: 1290 ELSHRVE----EKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCD 1345

Query: 973  ----------EQKQKMRRLGSDLTSAQKEMKTKHKA--------YENAVGILSRRLQEAL 1014
                      E K +++R  S   S   + +TK++          E A   L++RLQEA 
Sbjct: 1346 LLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1405

Query: 1015 AAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKE---LQEVIAL 1071
               E A+++   L        +   L   ++ L  +L+    +   L+K+     +V+A 
Sbjct: 1406 ENTETANSKCASL------EKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE 1459

Query: 1072 TSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAAL 1131
              Q+L+ES+    ELE   +ESR    ++ ++  + +++  +LE        L + N  L
Sbjct: 1460 WKQKLDESQ---AELEAAQKESRSLSTELFKMRNAYEEVVDQLE-------TLRRENKNL 1509

Query: 1132 REHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSL 1191
            +E  S L   +A+   +L +     + V    E+E   ++  ++ ++ SLE E+ K+  +
Sbjct: 1510 QEEISDLTEQIAETGKNLQEAEKTKKLV----EQEKSDLQVALEEVEGSLEHEESKILRV 1565

Query: 1192 KEQVAAAKVEAGH------------NRRHFKAASLELSEVKKELQAKE---HLVQKLQAE 1236
            + +++  K E                R   +AA    S +  E++++     L +K++ +
Sbjct: 1566 QLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD 1625

Query: 1237 ADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQK 1296
             ++++I+ G  ++++A+ Q  L   + QL+  Q  LD+ L                    
Sbjct: 1626 LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDAL-------------------- 1665

Query: 1297 EREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSEL 1356
             R  + LK+QL + E++    LE L+++    K  LE  +    +++++      +V  L
Sbjct: 1666 -RSNEDLKEQLAIVERRNGLLLEELEEM----KVALEQTERTRRLSEQELLDASDRVQLL 1720

Query: 1357 KNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRP 1416
             +   +L+   ++L+ D+ +  A+     + E+ ++       I D    A + EEL + 
Sbjct: 1721 HSQNTSLINTKKKLEADIAQCQAEVENSIQ-ESRNAEEKAKKAITDA---AMMAEELKK- 1775

Query: 1417 PPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448
                 ++   +L    + L+Q +  LQ +++E
Sbjct: 1776 ----EQDTSAHLERMKKNLEQTVKDLQHRLDE 1803


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  175 bits (444), Expect = 3e-43
 Identities = 246/1125 (21%), Positives = 475/1125 (42%), Gaps = 154/1125 (13%)

Query: 358  FPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEK--M 415
            F  IK +L++A  E + +   +  E +  +D +  S   E+   E +E+M+ +LKEK  +
Sbjct: 836  FFKIKPLLKSA--ETEKEMATMKEEFQKTKDELAKS---EAKRKELEEKMVTLLKEKNDL 890

Query: 416  RLEGQLEALSL-----EASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEV 470
            +L+ Q EA SL        Q +K K +L+A++  ++ + + + E +     ++  L  E 
Sbjct: 891  QLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDEC 950

Query: 471  DTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKD 530
              LK+   DLE  +  +                     E++      KV+++   M   D
Sbjct: 951  SELKKDIDDLELTLAKV---------------------EKEKHATENKVKNLTEEMAGLD 989

Query: 531  NTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQL-----ALA 585
             T+  L ++  ALQ   QQ           L+A + +++ L   +   +QQ+     +L 
Sbjct: 990  ETIAKLSKEKKALQETHQQT-------LDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLE 1042

Query: 586  QEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI 645
            QE ++R+  E A  ++    +      + +EN    QQL E   +   E   + ++++  
Sbjct: 1043 QEKKLRMDLERAKRKLEGDLKLAQESTMDMEND--KQQLDEKLEKKEFEISNLISKIE-- 1098

Query: 646  EADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTL 705
                 D++A  +Q+Q+    ++  ++   EE E ER    +     + L ++LE++   L
Sbjct: 1099 -----DEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL 1153

Query: 706  LQ----RDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGE----L 757
             +       Q+E  ++   +  K     +EA    E  + AL+  + +  A LGE    L
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213

Query: 758  QGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETS---------- 807
            Q      E     L+ E   L +  +A    K  L++  R LE+   E            
Sbjct: 1214 QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI 1273

Query: 808  ETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQ-KVMVEAYRRDATSKDQLI 866
              L   R  L  ++G+      E  AL  Q+ + K+   QQ + +      +  +K+ L 
Sbjct: 1274 NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALA 1333

Query: 867  SELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVR-------------- 912
              L+++R   D     LR++  +    K   +  LS+ + EVAQ R              
Sbjct: 1334 HALQSSRHDCDL----LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1389

Query: 913  --------QHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQ 964
                    Q + + E H+++   +   +E   Q LQ + E ++   E + A    +++ Q
Sbjct: 1390 EEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQ 1449

Query: 965  QEARKAITEQKQKMRRLGSDLTSAQKE--------MKTKHKAYENAVGILSRRLQEALAA 1016
            +   K ++E KQK     ++L ++QKE         K K+   E+   + + R +     
Sbjct: 1450 RNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQ 1509

Query: 1017 KEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQEL 1076
            +E +D  L +  A+GG         ++I  LE   + V   K  ++  L+E  A     L
Sbjct: 1510 QEISD--LTEQIAEGG---------KQIHELEKIKKQVEQEKCEIQAALEEAEA----SL 1554

Query: 1077 EESREKVLELEDELQE--SRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREH 1134
            E    K+L ++ EL +  S   RK  ++ EE ++   L+  H +   T     +A +R  
Sbjct: 1555 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ---LKRNHTRVVETMQSTLDAEIRSR 1611

Query: 1135 NSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKH---LVQALQASLEKEKEKVNSL 1191
            N  L     K E DL ++ +Q+    +   E  R  ++   +++  Q  L+        L
Sbjct: 1612 NDALRVK-KKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDL 1670

Query: 1192 KEQVAAAKVEAGHNRRHFKA--ASLELSEVKKELQAKEHL-----VQKLQAEADDLQIRE 1244
            KEQ+A  +  A   +   +   A+LE +E  +++  +E L     VQ L  +   L   +
Sbjct: 1671 KEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1730

Query: 1245 GKHSQEIAQFQAEL---------AEARAQLQLLQ-KQLDEQLSKQPVGNQEMENLKWEVD 1294
             K   +++Q Q+E+         AE +A+  +     + E+L K+   +  +E +K  ++
Sbjct: 1731 KKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1790

Query: 1295 QKEREIQ-SLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKV 1353
            Q  +++Q  L +   L  + G+K+++ L+  ++ ++ E+E  Q+  +   K     + +V
Sbjct: 1791 QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRV 1850

Query: 1354 SEL-----KNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSN 1393
             EL     ++    L  Q+   KL  +  + K + E   E S++N
Sbjct: 1851 KELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNAN 1895



 Score =  165 bits (417), Expect = 3e-40
 Identities = 232/1080 (21%), Positives = 451/1080 (41%), Gaps = 151/1080 (13%)

Query: 361  IKDVLQAAA-----AEHQDQGQEVNGEVRSRRDSI---CSSVS-----LESSAAETQEEM 407
            IK+ +Q  A      E  ++ +E+N E+ +++  +   CS +      LE + A+ ++E 
Sbjct: 912  IKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK 971

Query: 408  LQVLKEKMRLEGQLEALSLEASQALKEKAELQA-------QLAALSTKLQAQVECSHSSQ 460
                 +   L  ++  L    ++  KEK  LQ         L A   K+    +     +
Sbjct: 972  HATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLE 1031

Query: 461  QRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQR------ 514
            Q+ D L   ++  K+   DLERA   L+  L+    S     ND Q  +E+ ++      
Sbjct: 1032 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEIS 1091

Query: 515  -LMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTL---TSKLKASQAEISS 570
             L++K+ED Q   +     + +L+ ++  L  +++  +  R       S L     EIS 
Sbjct: 1092 NLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISE 1151

Query: 571  -LQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQH 629
             L+        Q+ L ++     Q     ++   +    ++  L+ ++     +L E   
Sbjct: 1152 RLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQID 1211

Query: 630  RSMKEKGRIAAQLQGI--EADMLDQEAAFM----------------QIQEAKTMVEEDLQ 671
               + K ++  +   +  E D L   A  +                Q+ E KT  EE+ Q
Sbjct: 1212 NLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTK-EEEQQ 1270

Query: 672  RRLEEFEGERERLQ-------RMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMK 724
            R + +   +R RLQ       R  D   +L  QL + K       QQ+E L+ +  +  K
Sbjct: 1271 RLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQA---STQQIEELKHQLEEETK 1327

Query: 725  QLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784
                   ALQS     D L+  Y+E Q    ELQ  A S+ ++           E A   
Sbjct: 1328 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ-RALSKANS-----------EVAQWR 1375

Query: 785  AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
             K   + + R        TEE  E  +KL + L      VE +  + A+L+K  Q+++ +
Sbjct: 1376 TKYETDAIQR--------TEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNE 1427

Query: 845  FLQQKVMVEAYRRDAT---------SKDQLISELK----ATRKRLDSELKELRQ---ELM 888
               + +M++  R +A          + D+++SE K     T+  L++  KE R    EL 
Sbjct: 1428 V--EDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485

Query: 889  QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDK-EQMV 947
            +V      +  +L  L RE   ++Q ++DL   +    K+  E+E   + ++ +K E   
Sbjct: 1486 KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA 1545

Query: 948  AVTEANEALKKQ---IEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVG 1004
            A+ EA  +L+ +   I  +Q E  +  +E  +K+     ++   ++      +  ++ + 
Sbjct: 1546 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD 1605

Query: 1005 ILSRRLQEALAAKEAADAELGQLRAQGGSSD----SSLALHERIQALEAELQAVSHSKTL 1060
               R   +AL  K+  + +L ++  Q   ++     SL  +   Q +  E Q        
Sbjct: 1606 AEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALR 1665

Query: 1061 LEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK 1120
             +++L+E +A+  +     + ++ EL   L+++           E ++K+A      + +
Sbjct: 1666 GQEDLKEQLAIVERRANLLQAEIEELWATLEQT-----------ERSRKIA------EQE 1708

Query: 1121 LTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR-KEEEDRQMKHLVQALQA 1179
            L    +    L   N+ L     K E D+ QL  +V+ V+Q  +  E++  K +  A   
Sbjct: 1709 LLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMM 1768

Query: 1180 SLEKEKEKVNS-----LKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQ 1234
            + E +KE+  S     +K+ +     +  H  R  +A  L L   KK++Q  E  V++L+
Sbjct: 1769 AEELKKEQDTSAHLERMKKNLEQTVKDLQH--RLDEAEQLALKGGKKQIQKLEARVRELE 1826

Query: 1235 AEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVD 1294
             E ++ Q R               AEA   L+  ++++ E   +     + +  L+  VD
Sbjct: 1827 GEVENEQKRN--------------AEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVD 1872

Query: 1295 QKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQE--DLSMTQKDKFMLQAK 1352
            + + +++S K+Q +  E+Q    L   ++L    + ELE A+E  D++ +Q +K  ++++
Sbjct: 1873 KLQAKVKSYKRQAEEAEEQSNANLSKFRKL----QHELEEAEERADIAESQVNKLRVKSR 1928



 Score =  150 bits (380), Expect = 7e-36
 Identities = 245/1156 (21%), Positives = 481/1156 (41%), Gaps = 180/1156 (15%)

Query: 460  QQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNND---LQVAEEQYQRLM 516
            ++ +D   +++ T  Q+         + Q ML+ + A      N    + V    + +L 
Sbjct: 777  EEMRDEKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLF 836

Query: 517  AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
             K++ + +S    +  +  ++++    + +L + + +R  L  K+     E + LQ   Q
Sbjct: 837  FKIKPLLKSA-ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 895

Query: 577  WYQQQLALAQEA-------RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTE--- 626
                 LA A+E        +++L+ ++  +      +  +   L  +   L  + +E   
Sbjct: 896  SEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKK 955

Query: 627  -------TQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
                   T  +  KEK     +++ +  +M   +    ++ + K  ++E  Q+ L++ + 
Sbjct: 956  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQA 1015

Query: 680  ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQS 739
            E +++  +  +   LEQQ++ ++ +L Q  +    L++    L   L L QE+    E  
Sbjct: 1016 EEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMEND 1075

Query: 740  LDALQTHYDELQARLGELQGEAASREDTICL-LQNEKIILEAALQAAKSGKE-ELDRGAR 797
               L    ++L+ +  E+    +  ED   + +Q +K I E   +  + G+E E +R +R
Sbjct: 1076 KQQLD---EKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132

Query: 798  RLEEG-----TEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV 852
               E      + E  E  E+L E     S QVE  ++  A  +K  + ++E  LQ + MV
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192

Query: 853  EAYR-RDATSKDQL---ISELKATRKRLDSELKELRQE---------------------- 886
             A R + A S  +L   I  L+  +++L+ E  EL+ E                      
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252

Query: 887  --LMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHL-------- 936
              L     E +T E E  RL  ++   R  +    G       E+D + + L        
Sbjct: 1253 RSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST 1312

Query: 937  QSLQFDKEQMVAVTEANEALKKQIE------ELQQEARKAITEQKQKMRRLGSDLTSAQK 990
            Q ++  K Q+   T+A  AL   ++      +L +E  +   E K +++R  S   S   
Sbjct: 1313 QQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1372

Query: 991  EMKTKHKA--------YENAVGILSRRLQEALAAKEAADAELGQL-----RAQGGSSDSS 1037
            + +TK++          E A   L++RLQEA    EA +A+   L     R Q    D  
Sbjct: 1373 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1432

Query: 1038 LALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDEL------- 1090
            L + ER  A  A L     +   +  E ++    T  ELE S+++   L  EL       
Sbjct: 1433 LDV-ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVY 1491

Query: 1091 -----------QESRGFRKKIKRLEE----------SNKKLALELEHEKGKLTGLGQSNA 1129
                       +E++  +++I  L E            +K+  ++E EK ++    +   
Sbjct: 1492 EESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAE 1551

Query: 1130 ALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMK----HLVQALQASLEKE- 1184
            A  EH    E  + + + +L Q+  +V   +  K+EE  Q+K     +V+ +Q++L+ E 
Sbjct: 1552 ASLEHE---EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608

Query: 1185 ---------KEK----VNSLKEQVAAAKVEAGHNRRHF-------KAASLEL-------S 1217
                     K+K    +N ++ Q+  A   A  + R++       K   L L        
Sbjct: 1609 RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE 1668

Query: 1218 EVKKELQAKEHLVQKLQAEADDL--QIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQ 1275
            ++K++L   E     LQAE ++L   + + + S++IA  + EL +A  ++QLL  Q    
Sbjct: 1669 DLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA--EQELLDASERVQLLHTQNTSL 1726

Query: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSE---- 1331
            ++ +    +++EN   +V Q + E++ + Q+    E++ +K +     + + +K E    
Sbjct: 1727 INTK----KKLEN---DVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTS 1779

Query: 1332 --LEMAQEDLSMTQKDKFMLQAKVSELKN-NMKTLLQQNQQLKLDLRRGAAKTRKEPKGE 1388
              LE  +++L  T KD   LQ ++ E +   +K   +Q Q+L+  +R        E +GE
Sbjct: 1780 AHLERMKKNLEQTVKD---LQHRLDEAEQLALKGGKKQIQKLEARVR--------ELEGE 1828

Query: 1389 ASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448
              +        +         ++EL        K  L+ L   + +L+ ++ S +RQ EE
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLR-LQDLVDKLQAKVKSYKRQAEE 1887

Query: 1449 HALTVHESLSSWTPLE 1464
                 + +LS +  L+
Sbjct: 1888 AEEQSNANLSKFRKLQ 1903



 Score = 95.9 bits (237), Expect = 3e-19
 Identities = 183/954 (19%), Positives = 373/954 (39%), Gaps = 137/954 (14%)

Query: 116  VRKEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKW---LEEQLKQYRVKRQQE 172
            +  E    ++L   ++E Q    +    +E E   R +A K    L  +L++   +R +E
Sbjct: 1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEIS-ERLEE 1155

Query: 173  RSSQPATKTRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHP 232
                 + +  L    + E      +L  A TL      + LR        +  LG     
Sbjct: 1156 AGGATSAQVELNKKREAEFQKLRRDLEEA-TLQHEAMVAALRKK--HADSMAELGEQIDN 1212

Query: 233  REKKTSKSSKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPD 292
             ++   K  K +S     T+D ++     N  A    KG+L++   S    VSE+    +
Sbjct: 1213 LQRVKQKLEKEKSELKMETDDLSS-----NAEAISKAKGNLEKMCRSLEDQVSELKTKEE 1267

Query: 293  TDDRLENTSLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPA 352
               RL N     D  ++     +++  YS                               
Sbjct: 1268 EQQRLIN-----DLTAQRARLQTEAGEYSRQLDE-------------------------- 1296

Query: 353  DTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLK 412
                     KD L +  +  +    +   E++ + +    + +  + A ++      +L+
Sbjct: 1297 ---------KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLR 1347

Query: 413  EKM--RLEGQLE---ALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLS 467
            E+     EG+ E   ALS   S+  + + + +      + +L+   E      QR     
Sbjct: 1348 EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELE---EAKKKLAQRLQEAE 1404

Query: 468  SEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSML 527
              V+ +   C  LE+    LQN +E           DL +  E+     A ++  QR+  
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVE-----------DLMLDVERSNAACAALDKKQRNF- 1452

Query: 528  SKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQE 587
              D  + + +Q+    Q++L+  Q E  +L++       E+  +++V +    QL   + 
Sbjct: 1453 --DKVLSEWKQKYEETQAELEASQKESRSLST-------ELFKVKNVYEESLDQLETLRR 1503

Query: 588  ARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEA 647
                LQ E++ +   Q+ + G   H          +L + + +  +EK  I A L+  EA
Sbjct: 1504 ENKNLQQEISDL-TEQIAEGGKQIH----------ELEKIKKQVEQEKCEIQAALEEAEA 1552

Query: 648  DMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQR-----MADSAASLEQQLEQVK 702
             +  +E   ++IQ     V+ ++ R++ E + E ++L+R     +    ++L+ ++    
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRN 1612

Query: 703  LTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQS---LDALQTHYDELQARLGELQG 759
              L  + +    L +  + L     L  E+L++   +   L   Q H D+      +L+ 
Sbjct: 1613 DALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKE 1672

Query: 760  EAASREDTICLLQNEKIILEAALQAAKSGK-----EELDRGARRLEEGTEETS--ETLEK 812
            + A  E    LLQ E   L A L+  +  +     E LD   R     T+ TS   T +K
Sbjct: 1673 QLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1732

Query: 813  LREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKAT 872
            L  +++    +VE + QE+   +   +K K+      +M E  +++  +     + L+  
Sbjct: 1733 LENDVSQLQSEVEEVIQES---RNAEEKAKKAITDAAMMAEELKKEQDTS----AHLERM 1785

Query: 873  RKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEM 932
            +K L+  +K+L+  L +        +  L    +++ ++   + +LEG +++ QK   E 
Sbjct: 1786 KKNLEQTVKDLQHRLDEAE------QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEA 1839

Query: 933  ETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEM 992
               ++ L+  + ++  +T   E  +K +  LQ    K   + K   R+         +E 
Sbjct: 1840 ---VKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQ--------AEEA 1888

Query: 993  KTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQA 1046
            + +  A  +    L   L+EA    + A++++ +LR +      S  +H +I A
Sbjct: 1889 EEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVK------SREVHTKISA 1936


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  175 bits (443), Expect = 3e-43
 Identities = 248/1125 (22%), Positives = 480/1125 (42%), Gaps = 160/1125 (14%)

Query: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ 420
            IK +L++A  E + +   +  E    ++++  S   E+   E +E+M+ +L+EK  L+ Q
Sbjct: 836  IKPLLKSA--EREKEMASMKEEFTRLKEALEKS---EARRKELEEKMVSLLQEKNDLQLQ 890

Query: 421  LEA-------LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTL 473
            ++A             Q +K K +L+A++  ++ +L+ + E +     ++  L  E   L
Sbjct: 891  VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950

Query: 474  KQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTV 533
            K+   DLE  +  +                     E++      KV+++   M   D  +
Sbjct: 951  KRDIDDLELTLAKV---------------------EKEKHATENKVKNLTEEMAGLDEII 989

Query: 534  HDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQL-----ALAQEA 588
              L ++  ALQ   QQ           L+A + ++++L   +   +QQ+     +L QE 
Sbjct: 990  AKLTKEKKALQEAHQQA-------LDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEK 1042

Query: 589  RVRLQGEMAHIQVG---QMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI 645
            +VR+  E A  ++    ++TQ  +++   LEN    QQL E     +K+K     +L  +
Sbjct: 1043 KVRMDLERAKRKLEGDLKLTQESIMD---LEND--KQQLDE----RLKKKD---FELNAL 1090

Query: 646  EADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTL 705
             A + D++A   Q+Q+    ++  ++   EE E ER    ++    + L ++LE++   L
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150

Query: 706  LQ----RDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEA 761
             +       Q+E  ++   +  K     +EA    E +  AL+  + +  A LGE   + 
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE---QI 1207

Query: 762  ASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKS 821
             + +     L+ EK   +  L    S  E++ +    LE+      + + + R +     
Sbjct: 1208 DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQ 1267

Query: 822  GQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELK-------ATRK 874
              V  L  + A L+ +  ++  Q  +++ ++    R   +  Q + +LK         + 
Sbjct: 1268 RSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN 1327

Query: 875  RLDSELKELRQE---LMQVHGEKRTAEAELSRL----HREVAQVR--------------- 912
             L   L+  R +   L + + E+  A+AEL R+    + EVAQ R               
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1387

Query: 913  -------QHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQ 965
                   Q + + E  +++   +   +E     LQ + E ++   E + A    +++ Q+
Sbjct: 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447

Query: 966  EARKAITEQKQKMRRLGSDLTSAQKE---MKTKHKAYENAVGILSRRLQEALAAKEAADA 1022
               K + E KQK     S+L S+QKE   + T+    +NA       L+      +    
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE 1507

Query: 1023 ELGQLRAQGGSSDSSLALHERI-QALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
            E+  L  Q GSS  ++   E++ + LEAE           + ELQ  +      LE    
Sbjct: 1508 EISDLTEQLGSSGKTIHELEKVRKQLEAE-----------KMELQSALEEAEASLEHEEG 1556

Query: 1082 KVLELEDELQESRG--FRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILE 1139
            K+L  + E  + +    RK  ++ EE  +     L       T L   +A  R  N  L 
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSL---DAETRSRNEALR 1613

Query: 1140 TALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQAL---QASLEKEKEKVNSLKEQVA 1196
                K E DL ++ +Q+    +   E  +Q+K L   L   Q  L+      + LKE +A
Sbjct: 1614 VK-KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIA 1672

Query: 1197 AAKVEAGHNRRHFK----AASLELSEVKKELQAKEHL-----VQKLQAEADDLQIREGKH 1247
               VE  +N    +     A +E +E  ++L  +E +     VQ L ++   L  ++ K 
Sbjct: 1673 I--VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM 1730

Query: 1248 SQEIAQFQAELAEARAQLQLLQKQ----------LDEQLSKQPVGNQEMENLKWEVDQKE 1297
              +++Q Q E+ EA  + +  +++          + E+L K+   +  +E +K  ++Q  
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ-- 1788

Query: 1298 REIQSLKQQLDLTEQ----QGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKV 1353
              I+ L+ +LD  EQ     G+K+L+ L+  ++ +++ELE  Q+  + + K     + ++
Sbjct: 1789 -TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI 1847

Query: 1354 SEL----KNNMKTLLQ-QNQQLKLDLRRGAAKTRKEPKGEASSSN 1393
             EL    + + K LL+ Q+   KL L+  A K + E   E +++N
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTN 1892



 Score =  160 bits (404), Expect = 1e-38
 Identities = 216/1054 (20%), Positives = 454/1054 (43%), Gaps = 139/1054 (13%)

Query: 483  AMTDLQNMLEAKNASLASSNND---LQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQ 539
            A  + + +LE +++ L    N    + V    + +L  K++ + +S   ++  +  ++++
Sbjct: 797  ARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSA-EREKEMASMKEE 855

Query: 540  MTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA-------RVRL 592
             T L+  L++ +  R  L  K+ +   E + LQ   Q  Q  LA A+E        +++L
Sbjct: 856  FTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQL 915

Query: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTE----------TQHRSMKEKGRIAAQL 642
            + ++  +      +  +   L  +   L  + +E          T  +  KEK     ++
Sbjct: 916  EAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV 975

Query: 643  QGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVK 702
            + +  +M   +    ++ + K  ++E  Q+ L++ + E +++  +  +   LEQQ++ ++
Sbjct: 976  KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035

Query: 703  LTLLQRDQQLEALQQEHLDLMKQLTLTQEA---LQSREQSLDALQTHYD----ELQARLG 755
             +L Q  +    L++    L   L LTQE+   L++ +Q LD      D     L AR+ 
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095

Query: 756  ELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLRE 815
            + Q   +  +  +  LQ     LE  L+A ++ + ++++    L    EE SE LE   E
Sbjct: 1096 DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE---E 1152

Query: 816  ELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRR----DATSKDQLISELKA 871
                 S Q+E  ++  A  +K  + ++E  LQ +    A R+          + I  L+ 
Sbjct: 1153 AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQR 1212

Query: 872  TRKRLDSELKELRQELMQVHGEK--------------RTAEAELSRLHREVAQVRQHMAD 917
             +++L+ E  E + EL  V                  RT E +++    +  + ++ + D
Sbjct: 1213 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND 1272

Query: 918  LEGHLQSAQKERDEMETHLQSLQFDKEQM----VAVTEANEALKKQIEE----------- 962
            L       Q E  E+   L   +    Q+    +  T+  E LK+Q+EE           
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332

Query: 963  ---------LQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKA--------YENAVGI 1005
                     L +E  +  TE K +++R+ S   S   + +TK++          E A   
Sbjct: 1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1392

Query: 1006 LSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKE- 1064
            L++RLQEA  A EA +A+   L        +   L   I+ L  +++  + +   L+K+ 
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSL------EKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446

Query: 1065 --LQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLT 1122
                +++A   Q+ EES+    ELE   +E+R    ++ +L+ + ++    LEH    L 
Sbjct: 1447 RNFDKILAEWKQKYEESQS---ELESSQKEARSLSTELFKLKNAYEE---SLEH----LE 1496

Query: 1123 GLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
               + N  L+E  S L   L      + +L    + V ++ E E  +++  ++  +ASLE
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHEL----EKVRKQLEAEKMELQSALEEAEASLE 1552

Query: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKK-ELQAKEHLVQKLQAEA---- 1237
             E+ K+  L+ Q+   +++A   R+       E+ + K+  L+  + L   L AE     
Sbjct: 1553 HEEGKI--LRAQLEFNQIKAEIERK-LAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRN 1609

Query: 1238 DDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKE 1297
            + L++++ K   ++ + + +L+ A       QKQ+    S        +++ + ++D   
Sbjct: 1610 EALRVKK-KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSL-------LKDTQIQLDDAV 1661

Query: 1298 REIQSLKQQLDLTEQQG---RKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVS 1354
            R    LK+ + + E++    + ELE L+ +++  +   ++A+++L  T +   +L ++ +
Sbjct: 1662 RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1721

Query: 1355 ELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELL 1414
             L N  K +     QL+ ++     + R   +    +   A           A + EEL 
Sbjct: 1722 SLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDA-----------AMMAEELK 1770

Query: 1415 RPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448
            +      ++   +L    + ++Q +  LQ +++E
Sbjct: 1771 K-----EQDTSAHLERMKKNMEQTIKDLQHRLDE 1799



 Score =  160 bits (404), Expect = 1e-38
 Identities = 231/1072 (21%), Positives = 449/1072 (41%), Gaps = 154/1072 (14%)

Query: 371  EHQDQGQEVNGEVRSRRDSICSSVS-LESSAAETQEEMLQVLKEKMRLEGQLEALSLEAS 429
            E  +  +E+N E+ +++  +    S L+    + +  + +V KEK   E +++ L+ E +
Sbjct: 924  ERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMA 983

Query: 430  -------QALKEKAELQA-------QLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQ 475
                   +  KEK  LQ         L A   K+    +     +Q+ D L   ++  K+
Sbjct: 984  GLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043

Query: 476  SCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD 535
               DLERA   L+  L+    S+    ND Q  +E+ ++     +D + + L+    + D
Sbjct: 1044 VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKK-----KDFELNALNA--RIED 1096

Query: 536  LRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE 595
             +   + LQ +L+++Q     L  +L+A +   + ++ +R    ++L    E      G 
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1156

Query: 596  MA-HIQVGQMTQAGL------LEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEAD 648
             +  I++ +  +A        LE   L++ + +  L +    S+ E G     LQ ++  
Sbjct: 1157 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1216

Query: 649  MLDQEAAFM-----------QIQEAKTMVE-----------------EDLQRRLEEFEGE 680
            +  +++ F            QI +AK  +E                 E+ QR + +   +
Sbjct: 1217 LEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQ 1276

Query: 681  RERLQ-------RMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEAL 733
            R +LQ       R  D   +L  QL + KLT     QQLE L+++  + +K       AL
Sbjct: 1277 RAKLQTENGELSRQLDEKEALISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALAHAL 1333

Query: 734  QSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAK-SGKEEL 792
            QS     D L+  Y+E      ELQ                +++ +A  + A+   K E 
Sbjct: 1334 QSARHDCDLLREQYEEETEAKAELQ----------------RVLSKANSEVAQWRTKYET 1377

Query: 793  DRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV 852
            D   R     TEE  E  +KL + L      VE +  + ++L+K   +++ +   + +MV
Sbjct: 1378 DAIQR-----TEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI--EDLMV 1430

Query: 853  EAYRRDATSK---------DQLISELKATRKRLDSELKELRQELMQVHGE----KRTAEA 899
            +  R +A +          D++++E K   +   SEL+  ++E   +  E    K   E 
Sbjct: 1431 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1490

Query: 900  ELSRLH---REVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEAL 956
             L  L    RE   +++ ++DL   L S+ K   E+E   + L+ +K ++ +  E  EA 
Sbjct: 1491 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS 1550

Query: 957  KKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKH----KAYENAVGILSRRLQE 1012
             +  E     A+    + K ++ R  ++     ++ K  H     + + ++   +R   E
Sbjct: 1551 LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE 1610

Query: 1013 ALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALT 1072
            AL  K+  + +L ++  Q          H    A EA+ Q  S    L + ++Q   A+ 
Sbjct: 1611 ALRVKKKMEGDLNEMEIQ--------LSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1662

Query: 1073 SQELEESREKVLELEDEL--QESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAA 1130
            + +  +    ++E  + L   E    R  +++ E S K    EL     ++  L   N +
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722

Query: 1131 LREHNSILETALAKREADLVQLNLQV-QAVLQRKEEEDRQMKHLVQALQASLEKEKEKVN 1189
            L            K +ADL QL  +V +AV + +  E++  K +  A   + E +KE+  
Sbjct: 1723 LINQKK-------KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775

Query: 1190 S-----LKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIRE 1244
            S     +K+ +     +  H  R  +A  + L   KK+LQ  E  V++L+ E +  Q R 
Sbjct: 1776 SAHLERMKKNMEQTIKDLQH--RLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRN 1833

Query: 1245 GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
             +  + + + +  + E   Q +  +K L             +++L   VD+ + ++++ K
Sbjct: 1834 AESVKGMRKSERRIKELTYQTEEDRKNL-----------LRLQDL---VDKLQLKVKAYK 1879

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSEL 1356
            +Q +  E+Q    L   ++    V+ EL+ A+E   + +     L+AK  ++
Sbjct: 1880 RQAEEAEEQANTNLSKFRK----VQHELDEAEERADIAESQVNKLRAKSRDI 1927


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  175 bits (443), Expect = 3e-43
 Identities = 253/1183 (21%), Positives = 497/1183 (42%), Gaps = 141/1183 (11%)

Query: 361  IKDVLQAAAAEHQDQGQ--------EVNGEVRSRRD--SICSSVSLESSAAETQEEMLQV 410
            IKD+ Q    E  +  Q        E++  + S+ D      +++L  S    + + +Q 
Sbjct: 345  IKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQD 404

Query: 411  LKEKMRLEGQLEALSL---------EASQALKEKAEL----QAQLAALSTKLQAQVECSH 457
            L+++  L G  EA++L         E  +AL+++ +     +  LA  +  LQ +V+   
Sbjct: 405  LRQQ--LAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLS 462

Query: 458  SS----QQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVA---EE 510
                  Q+ ++ L  +++ L+Q  W L R   +LQ   ++          +L +A    E
Sbjct: 463  KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE 522

Query: 511  QYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS 570
            + Q ++  +E  Q   LS+  T+ +  +        L+Q Q E T   ++ + S AE+SS
Sbjct: 523  RLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSS 582

Query: 571  LQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHR 630
             ++                  L+ E+A ++   +  + L E L L+ V L+QQL + +  
Sbjct: 583  SENT-----------------LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE 625

Query: 631  SMKEKGRIAAQLQ---GIEADMLDQEAAFMQIQEAKTMVEEDLQRR----------LEEF 677
            +     R+ A  Q    ++ D+ + E     + E  T +E  LQ+           L + 
Sbjct: 626  NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685

Query: 678  EGERERLQRMADSAASLEQ----QLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEAL 733
            + E+E +Q+    +   ++    QLEQ+     ++++ L    QE   L+++    +  L
Sbjct: 686  QEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRL 745

Query: 734  QSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELD 793
            Q+ E+    L      L +    L+      +    +++  K  LE  +Q     KE + 
Sbjct: 746  QAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805

Query: 794  RGARRLEEGTEETSETLEKLREELAIKSGQVEH-----LQQETAALKKQMQKIKEQFLQQ 848
               R L+   +      E+ R+  A +  Q E      L+Q+ AA +K++ +++E++ ++
Sbjct: 806  GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865

Query: 849  KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQEL--MQVHGEKRTAEAELSRLHR 906
            +    ++ +   +K   +  L+  +  L+  LKE + E+  +Q   E+   +AE +    
Sbjct: 866  R----SWHQQELAK--ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919

Query: 907  EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFD-KEQMVAVTEANEALKKQIEELQQ 965
            ++   ++ ++ LE  LQ+ QKE  +    L+ L+ D K Q +   E    L+ Q++E Q+
Sbjct: 920  QLETEKERVSLLETLLQT-QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978

Query: 966  EARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG 1025
            E ++A  + +  +  L  + +S  ++     K  E+    L  +       ++    +L 
Sbjct: 979  ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLR 1038

Query: 1026 QLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKE-----LQEVIALTSQELEESR 1080
            + +            + RIQ  E E +  S + +L+EKE     LQE  ++  QEL   R
Sbjct: 1039 ETQE-----------YNRIQK-ELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR 1086

Query: 1081 EKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILET 1140
            + + E + E +E     + ++  +E  +K A  L  E   L  L  S+   ++    L  
Sbjct: 1087 QDMQEAQGEQKELSAQMELLR--QEVKEKEADFLAQEAQLLEELEASHITEQQ----LRA 1140

Query: 1141 ALAKREADLVQLNLQVQAVLQRKE------------EEDRQMKHLVQALQASLEKEKEKV 1188
            +L  +EA   QL L++++   + E            +   Q+  L  ALQ +L    E  
Sbjct: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR 1200

Query: 1189 NSLK------EQVAAAKVEAGHNRRHFK----AASLELSEVKKELQAKEHLVQKLQAEAD 1238
              L         V   + +    R  FK      +L    V   L      + K Q   D
Sbjct: 1201 PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRD 1260

Query: 1239 DLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER 1298
             L+ +  K  + +   +AE ++   +LQ LQ+QL +   ++     +  +L+ E+ +   
Sbjct: 1261 VLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE 1320

Query: 1299 EIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKN 1358
             + SL+ +L   E Q R E +G ++LLQ  K  L    E L     +     +    L+ 
Sbjct: 1321 TMASLQSRLRRAELQ-RMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEE 1379

Query: 1359 NMKT----LLQQNQQLKLDLRRGAAKTR----KEPKGEASSSNPATPIKI-----PDCPV 1405
            +++T    L  +N++++ +  R  A       K  +G+A   N A   +       +   
Sbjct: 1380 DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET 1439

Query: 1406 PASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448
                ++E L     + K  L+ L+  L++  QE+D  Q Q++E
Sbjct: 1440 LRGQIQE-LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481



 Score =  171 bits (434), Expect = 4e-42
 Identities = 249/1078 (23%), Positives = 469/1078 (43%), Gaps = 143/1078 (13%)

Query: 362  KDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQL 421
            +++LQAA      Q + +   V   R         ++SAA   EE L+  +  ++L+ + 
Sbjct: 1343 RELLQAAKENLTAQVEHLQAAVVEAR--------AQASAAGILEEDLRTARSALKLKNEE 1394

Query: 422  EALSLEASQALKEKAELQ-AQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDL 480
                 E +QAL+E+ EL+ AQ  AL   L    +     ++       EV+TL+    +L
Sbjct: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREE-------EVETLRGQIQEL 1447

Query: 481  ERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSK-DNTVHDLRQQ 539
            E+     +  LE  +  L   N ++ + +EQ Q L     +  RS+L      V +  Q+
Sbjct: 1448 EKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL-----EKCRSVLEHLPMAVQEREQK 1502

Query: 540  MTALQSQLQQVQLERTTLTSKLKASQAEISS----LQSVRQWYQ---------QQLALAQ 586
            +T  + Q+++++ +R T  + L+    E+      ++S R   Q         + LAL  
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562

Query: 587  EA---RVRLQGEMAHIQVGQM-TQAGLLEHLKLENVSLSQQLTETQ---HRSMKEKGRIA 639
            E    ++  Q ++     GQ  TQ   L HL L+    SQ+L       H        +A
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622

Query: 640  AQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAAS----LE 695
             +LQ  + ++  Q     ++Q  K  + +DL+RR +E   ++ER+Q + D        LE
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE 1682

Query: 696  QQLEQVKLTLLQRDQQLEA---LQQEHLDLMKQLTLTQEA--------LQSREQSLDALQ 744
            + LEQ+KL+L +R ++L     L QE  +  K  +  Q          L+ +E+ ++  Q
Sbjct: 1683 EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQ 1742

Query: 745  THYDELQARLGELQGEAASR-----EDTICLLQNEK--IILEAALQAAKSGKEELDRGAR 797
             H  ELQ    +L+ +         E ++ L Q E+  ++L+  LQ A+   E       
Sbjct: 1743 EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE------- 1795

Query: 798  RLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRR 857
             L+E  +     L++ +  LA +  ++E LQQE    + Q +++KE+    +  +E    
Sbjct: 1796 -LKE--QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHM 1852

Query: 858  DATSKDQLISELKATRKRLDSEL-------KELRQELMQVHGEKRTAEAELSRLHREVA- 909
                +   + + K   +RL+ EL       + L + L  +  E R  E  L  L ++ A 
Sbjct: 1853 TLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE 1912

Query: 910  QVRQHMADLEG------HLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEEL 963
            Q ++H  +           Q+  KERD+    L++L+ + +      EA  A  + ++E 
Sbjct: 1913 QAQEHEVETRALQDSWLQAQAVLKERDQ---ELEALRAESQSSRHQEEAARARAEALQEA 1969

Query: 964  QQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAE 1023
              +A  A+  ++Q +    ++L+ + +      +A  +A    SR+L+EAL  +E  + +
Sbjct: 1970 LGKAHAALQGKEQHLLEQ-AELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG-EIQ 2027

Query: 1024 LGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKV 1083
               LR Q        AL +R    + EL+     + LLEK L + +    QE     ++ 
Sbjct: 2028 DQDLRYQEDVQQLQQALAQR----DEELRHQQEREQLLEKSLAQRV----QENMIQEKQN 2079

Query: 1084 LELEDELQESRGFRKKIKRLE-----ESNKKLALELEHEKGKLTGLGQSN--AALREHNS 1136
            L  E E +E RG  + ++ L+     +  + L L    ++  L  L  S+  + + E + 
Sbjct: 2080 LGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSL 2139

Query: 1137 ILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVA 1196
             L++   + + +L +L    QA L++ E  + + +   Q L  SL + K  V+SL+E   
Sbjct: 2140 KLDSLEPRLQRELERL----QAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAM 2195

Query: 1197 AAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIR--EGKHSQEIAQF 1254
              +          +    EL   ++ L+ KE L         +L  R  +G    E++  
Sbjct: 2196 FLQASVLERDSEQQRLQDELELTRRALE-KERLHSPGATSTAELGSRGEQGVQLGEVSGV 2254

Query: 1255 QAELAEARAQLQLLQKQLDEQLSKQPVGNQEMEN---------LKWEVDQKEREIQSLKQ 1305
            +AE +    + Q  +++L+    +Q V   E++          L+  ++Q ERE + LK+
Sbjct: 2255 EAEPSPDGMEKQSWRQRLEHL--QQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKR 2312

Query: 1306 Q---------LDL--------TEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDK 1346
            +         L++        T+Q GR +     + +  ++ E+ + Q  L++ +K K
Sbjct: 2313 EAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQK 2370



 Score =  165 bits (418), Expect = 3e-40
 Identities = 248/1152 (21%), Positives = 485/1152 (42%), Gaps = 173/1152 (15%)

Query: 404  QEEMLQVLKEKMR-LEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQR 462
            QE     L+ ++R  E QLEAL+ E  Q    +A+ QAQLA+L + LQ   +   S  + 
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAE--QQPGNQAQAQAQLASLYSALQ---QALGSVCES 1199

Query: 463  QDSLSSEVDTLKQSCWDLERAMTDLQNML-----------EAKNASLASSNNDLQVAEEQ 511
            +  LS   D+   S W LE      +++            EA  ++L   + DL   ++ 
Sbjct: 1200 RPELSGGGDSAP-SVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQT 1258

Query: 512  YQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSL 571
               L  +V+ ++  +   +     +  ++  LQ QL Q Q E++    K  + ++E+  L
Sbjct: 1259 RDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMEL 1318

Query: 572  QSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRS 631
                   Q +L  A+  R+  QGE   +Q  +      +EHL+   V             
Sbjct: 1319 HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE------------ 1366

Query: 632  MKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSA 691
                    A+ Q   A +L+++     ++ A++     L+ + EE E ERER Q + +  
Sbjct: 1367 --------ARAQASAAGILEED-----LRTARSA----LKLKNEEVESERERAQALQEQG 1409

Query: 692  A-------SLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQ 744
                    +L++ L  +  TL +R++++E L+ +  +L KQ  + + AL+     L    
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRN 1469

Query: 745  THYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTE 804
               D  Q ++ EL       E    +L++  + ++   Q     +E++    R LE+  E
Sbjct: 1470 QEVDLQQEQIQEL-------EKCRSVLEHLPMAVQEREQKLTVQREQI----RELEKDRE 1518

Query: 805  ETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQ 864
                 LE    EL  K   +E  + +   LKKQ+  ++   L+    +E        + +
Sbjct: 1519 TQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE----LEENHHKMECQQK 1574

Query: 865  LISELKATRK-------RLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMAD 917
            LI EL+  R+        L  +L+E  QEL     +    E+  + L RE+ +  Q +  
Sbjct: 1575 LIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634

Query: 918  LEGHLQSAQKERD----EMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITE 973
                ++  Q++++    ++E   Q L   KE++  + +      K +EE  ++ + ++ E
Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRE 1694

Query: 974  QKQKMRRLGSDLTSAQKEMKTKHKAYENAVG---ILSRRLQEALAAKEAADAELGQLRAQ 1030
            + +++      +    +E K   KA   ++    ++ R  ++ +  ++    EL +L+ Q
Sbjct: 1695 RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQ 1754

Query: 1031 GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE----KVLEL 1086
                     L +++Q L  +   V  +  LL +  QE++ L  Q+L+E+RE    K   L
Sbjct: 1755 ---------LEQQLQGLHRK---VGETSLLLSQREQEIVVL-QQQLQEAREQGELKEQSL 1801

Query: 1087 EDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE 1146
            + +L E+   ++ + + ++  + L  E +  +G+   + +   AL+         L +R 
Sbjct: 1802 QSQLDEA---QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858

Query: 1147 ADLVQLNLQVQAVLQRKEEEDRQMKHLVQA---LQASLEKEKEKVNSLKEQVAAAKVEAG 1203
             +L     Q + + +    E R+++ L +    L+A   ++++ + +L++Q A    E  
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918

Query: 1204 HNRRH-----------FKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGK------ 1246
               R             K    EL  ++ E Q+  H  +  +A A+ LQ   GK      
Sbjct: 1919 VETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ 1978

Query: 1247 ----HSQEIAQFQAELAEARAQLQLL-------QKQLDEQLSKQPVGNQEMENLKWEVDQ 1295
                H  E A+    L  + A LQ          +QL+E L  Q  G  + ++L+++ D 
Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE-GEIQDQDLRYQEDV 2037

Query: 1296 KEREIQSLKQQLDLTEQQGRKEL----------EGLQQLLQNVKSELE----------MA 1335
            ++ +    ++  +L  QQ R++L          E + Q  QN+  E E          + 
Sbjct: 2038 QQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVR 2097

Query: 1336 QEDLSMTQKDKFMLQAKVSELKNNM-------KTLLQQNQQLKLD---------LRRGAA 1379
            +  L++ QK++ +L+ + ++ +NN+       KT   + Q LKLD         L R  A
Sbjct: 2098 ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157

Query: 1380 KTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEM 1439
              R+    E      A  + +      AS+    L+      +  +   +S  Q+L+ E+
Sbjct: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASV--SSLQEVAMFLQASVLERDSEQQRLQDEL 2215

Query: 1440 DSLQRQMEEHAL 1451
            +  +R +E+  L
Sbjct: 2216 ELTRRALEKERL 2227



 Score =  133 bits (334), Expect = 1e-30
 Identities = 223/983 (22%), Positives = 417/983 (42%), Gaps = 149/983 (15%)

Query: 362  KDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQV-LKEKM--RLE 418
            ++VL+    E + + Q +  +    +D     V+LE  A E +E   ++  ++K+   LE
Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580

Query: 419  GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCW 478
            GQ E   +  +    +  E   +L A S+++      S    +       EV + ++   
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640

Query: 479  DLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKV--EDMQRSMLSKDNTVHDL 536
            +L+R    L   LE ++  L      +QV E+Q  R   K+  ED+++  LS      +L
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR-QTKILEEDLEQIKLSLRERGREL 1699

Query: 537  RQQMTALQ---------SQLQQVQLERTTL-----TSKLKASQAEISSLQSVRQWYQQQL 582
              Q   +Q         S+ Q+  LE   L       +++  Q  I  LQ ++   +QQ 
Sbjct: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQ- 1758

Query: 583  ALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQL 642
                     LQG   H +VG+ +   LL   + E V L QQL E + +   ++  + +QL
Sbjct: 1759 ---------LQG--LHRKVGETSL--LLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL 1805

Query: 643  QGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVK 702
               EA    Q A   + QE      E LQ+  ++ +G+ ER++  AD   +L+  LEQ  
Sbjct: 1806 D--EA----QRALAQRDQEL-----EALQQEQQQAQGQEERVKEKAD---ALQGALEQAH 1851

Query: 703  LTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAA 762
            +TL +R  +L+  +++   L ++L +    +Q+ E+               LG+L+ E+ 
Sbjct: 1852 MTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV--------------LGDLRAESR 1897

Query: 763  SREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSG 822
             +E  +  LQ      + A QA     +E +   R L++   +    L++  +EL     
Sbjct: 1898 EQEKALLALQQ-----QCAEQA-----QEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947

Query: 823  QVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKE 882
            + +  + +  A + + + ++E   +    ++   +    + +L   L+A+   L + L  
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDA 2007

Query: 883  LRQELMQVHGEKRTAEAELS----RLHREVAQVRQHMADLEGHLQSAQKERDEMETHL-- 936
             +    Q+    R  E E+     R   +V Q++Q +A  +  L+  Q+    +E  L  
Sbjct: 2008 CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQ 2067

Query: 937  ---QSLQFDKEQMVAVTEANE--ALKKQIEELQ----QEARKAI----TEQKQKMRRL-G 982
               +++  +K+ +    E  E   L + + ELQ    Q+ ++ +    T+Q+  +  L  
Sbjct: 2068 RVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPH 2127

Query: 983  SDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHE 1042
            S  TS  +E   K  + E  +     RLQ AL   EA + E                  E
Sbjct: 2128 SHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIE----------------WRE 2171

Query: 1043 RIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR 1102
            + Q L   L     S +     LQEV       + E   +   L+DEL+ +R   +K +R
Sbjct: 2172 KAQDLALSLAQTKASVS----SLQEVAMFLQASVLERDSEQQRLQDELELTRRALEK-ER 2226

Query: 1103 LEESNKKLALELEH------EKGKLTGL-------GQSNAALREHNSILETALAKREADL 1149
            L         EL        + G+++G+       G    + R+    L+ A+A+ E D 
Sbjct: 2227 LHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDR 2286

Query: 1150 VQL---NLQVQAVLQRKEEEDRQMK-HLVQALQA-SLEKEKEKVNSLKEQVAAAKVEAGH 1204
             +L   N+Q+++ L++ E E R++K   ++A QA SLE  K   +S  +Q        G 
Sbjct: 2287 SRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQ-------DGR 2339

Query: 1205 NRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAE---A 1261
             +++  A    ++E++KE+   +  +   + +  D   R  + S+E+A     L+    A
Sbjct: 2340 GQKNSDAKC--VAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLA 2397

Query: 1262 RAQ------LQLLQKQLDEQLSK 1278
             AQ      L+   ++LDE L++
Sbjct: 2398 VAQAPEATVLEAETRRLDESLTQ 2420



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 93/436 (21%), Positives = 178/436 (40%), Gaps = 24/436 (5%)

Query: 1038 LALHERIQALE---AELQAVSHSKTLLEKELQEVIALTSQELE----ESREKVLELEDEL 1090
            L L E++ AL+   AE QA S  K    +E Q+  A   ++L+    + R    ELE  L
Sbjct: 18   LVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRL 77

Query: 1091 QESRG-FRKKIKRLEESN-KKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREAD 1148
            + + G   ++ + +EE N  +L + LE E+ +   L + N  LR H    +        D
Sbjct: 78   EATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALRED 137

Query: 1149 LVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRH 1208
            + +L +           ++ Q +   +  +  L+ E  ++ SL  +V          RRH
Sbjct: 138  VEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF-------RRH 190

Query: 1209 FKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLL 1268
            F            EL+A EH+          L++  G  S+E            AQL LL
Sbjct: 191  FLEMKSATDRDLMELKA-EHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLL 249

Query: 1269 QKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNV 1328
              +  E   +    +QE+  LK + D ++ E+Q    +L     Q +K+ E  +++++ +
Sbjct: 250  LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309

Query: 1329 KSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGE 1388
            +  +E+ + + +   + +  L     E K +++ +++   Q+ ++     A+        
Sbjct: 310  RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369

Query: 1389 ASSSNPATPIKIPDCPVPASLLEELL-RPPPAVS--KEPLKNLNSCLQQLKQEMDSLQRQ 1445
               S+  +     D     +L+  +L R   AV   ++ L      +  L+Q+ D    Q
Sbjct: 370  ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD----Q 425

Query: 1446 MEEHALTVHESLSSWT 1461
             EE    + + L   T
Sbjct: 426  WEEEGKALRQRLQKLT 441


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  174 bits (440), Expect = 8e-43
 Identities = 270/1251 (21%), Positives = 528/1251 (42%), Gaps = 196/1251 (15%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSS--VSLESSAAETQEEMLQVLKEKMRLEGQLE 422
            LQ    ++Q + +++  +    ++++     +  ++   E  E+ L+ L  K   + +LE
Sbjct: 631  LQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK---QTELE 687

Query: 423  ALSLEASQALKEKAELQAQLAAL---STKLQAQVECS-----HSSQQRQDSLSSEVDT-- 472
            +LS E S+ LK + +L+ +L+ L   + K++ ++E       +  QQ+ DS+  E +   
Sbjct: 688  SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSI 747

Query: 473  ------LKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSM 526
                  LK     LE  + +    L+   A + +   D++ +E + Q+  AK++  Q   
Sbjct: 748  QRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 807

Query: 527  LSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQ 586
             +         +Q+  LQ +L  ++ ER  LT ++   +A+   + +    ++ Q+    
Sbjct: 808  SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867

Query: 587  EARVRLQGEMAHIQVGQMTQA--GLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQG 644
            +   +   EM   +V  +TQ     LE    E     Q L E ++  ++ +     +++ 
Sbjct: 868  QQLEKQNSEMEQ-KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926

Query: 645  IEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQ-----RMADSAASLEQQLE 699
            +   +  +E +   + E      ++ ++++E+ + + + +Q     ++ D  A L+++LE
Sbjct: 927  LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986

Query: 700  QVKLTLLQRDQQLEALQQEHL--------DLMKQLTLTQEALQSREQSLDALQTHYDEL- 750
               L L Q+++Q  A   E          D + +L   Q     +EQ     + H  EL 
Sbjct: 987  NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ-----KEQIESLTEVHRRELN 1041

Query: 751  ------QARLGELQGEAASREDTICLLQNEKIILEAALQAAKSG--KEELDRGARRLEEG 802
                  + +L + Q E       I L + E+ + E   +    G  KEE+++    L+E 
Sbjct: 1042 DVISIWEKKLNQ-QAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEE 1100

Query: 803  TEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK--------------EQFLQQ 848
              +   TL +L+E+L  KS  V  L Q+   LK  ++K++              EQ ++ 
Sbjct: 1101 GVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL 1160

Query: 849  KVMVEAYRR---DATSK----DQLISELKATRKRLDS-------ELKELRQEL-MQV--- 890
            K++ E  +R   + TSK    D+    LK++ ++ +        E K+L +EL +Q+   
Sbjct: 1161 KMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDIC 1220

Query: 891  -------------------------------HGEKRTAEAE---------LSRLHREVAQ 910
                                           H + RT + +         +S L  ++ Q
Sbjct: 1221 CKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQ 1280

Query: 911  VRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKA 970
            + +    L    Q A  + +E E  ++S++ D E +V   EA +      ++   E    
Sbjct: 1281 LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESC 1340

Query: 971  ITEQKQKMRRLGSDLTSAQKEMKTKH---KAYENAVGILSRRLQEALAAKEAADAELGQL 1027
            IT+ K+++    + +T  ++E+K K     +    +  L+ +LQ +++  E  +A +  L
Sbjct: 1341 ITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE-KEAAISSL 1399

Query: 1028 RAQGGSSDSSL-------------ALHERIQALE---------------AELQAVSHSKT 1059
            R Q       L                E+I ALE               A+ +   H  T
Sbjct: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459

Query: 1060 LLEKELQEVIALTSQELEESREKVLELEDEL-QESRGFRKKIKRLEESNKKLALELEHEK 1118
            +  KELQ  + L S+E  E  E++  L++EL Q+++ F      +E+   K+    + E 
Sbjct: 1460 V--KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKME---KKES 1514

Query: 1119 GKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQ 1178
               T L    A + E    LE  + ++  ++  LN   + +    +++D + K LVQ LQ
Sbjct: 1515 NLETELKSQTARIME----LEDHITQKTIEIESLN---EVLKNYNQQKDIEHKELVQKLQ 1567

Query: 1179 ASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEAD 1238
               E  +EK N +KE  A  K+    N+ +   A LE    KKEL   EH+   ++++ +
Sbjct: 1568 HFQELGEEKDNRVKE--AEEKILTLENQVYSMKAELETK--KKEL---EHVNLSVKSKEE 1620

Query: 1239 DLQIREGKHSQEIAQFQAEL-AEARAQLQLLQKQLDEQLSKQPV-----GNQEMENLKWE 1292
            +L+  E +   E A   AEL  +A  ++  ++KQL  Q+ ++           +  L  +
Sbjct: 1621 ELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680

Query: 1293 VDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAK 1352
            + ++ERE+  L+++L   E   + E   + +  +NV +  E  + D     +  +  + K
Sbjct: 1681 LQEREREVHILEEKLKSVE-SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTY--EEK 1737

Query: 1353 VSELKNNM---KTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASL 1409
            +S L+ N+   + LLQ+  Q K +      + R + +        A   +  D  +   L
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHL 1797

Query: 1410 LEEL--------LRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALT 1452
             EEL        L     V KE  KN     Q L+   D +Q+ ++E  LT
Sbjct: 1798 QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELT 1848



 Score =  169 bits (427), Expect = 2e-41
 Identities = 257/1133 (22%), Positives = 492/1133 (43%), Gaps = 160/1133 (14%)

Query: 355  LGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAET-QEEMLQVLKE 413
            L Q   +K  L+  A E   + ++ N ++     +  + +S   S  ET Q+E ++ L E
Sbjct: 975  LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034

Query: 414  KMRLEGQLEALSLEASQALKEKAELQA-QLAALSTKLQAQVECSHSSQQ---RQDSLSSE 469
              R E   + +S+   +  ++  ELQ      L  K Q   E           ++ ++ E
Sbjct: 1035 VHRRELN-DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1093

Query: 470  VDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVE-DMQRSMLS 528
            +  LK+     +  + +LQ  L+ K+A +    N L   E + +  + K+E D+ +S+  
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHV----NSLAQDETKLKAHLEKLEVDLNKSL-- 1147

Query: 529  KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA 588
            K+NT   L++Q+  L+   ++ + + + LTSKLK +  E  SL+S  +   + L      
Sbjct: 1148 KENTF--LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLE 1205

Query: 589  RVRLQGEMA-HIQVGQMTQAGLLEHLKLENVSLSQQLTET--------QHRSMKEKGRIA 639
              +L  E+A  + +       LLE    E +++S   T          QHR+ K K  + 
Sbjct: 1206 FKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL 1265

Query: 640  AQ---LQGIEADML----DQEAAFMQIQEAKTMVEE------DLQRRLEEFEGERERLQR 686
             +   +  +EA +     +Q    +  Q+A   +EE       ++  +E    E+E LQ+
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQK 1325

Query: 687  ----MADSAASLEQQLEQVKLTLLQR-------DQQLEALQQEHLDLMKQLTLTQEALQS 735
                   +A+  E  + Q+K  L +         ++L+  + E   L KQLT     LQ+
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385

Query: 736  ------REQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGK 789
                  +E ++ +L+  YDE +  L +   + + + DT   L  EKI   +AL+      
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT---LSKEKI---SALEQVDDWS 1439

Query: 790  EELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQK 849
             +     ++ +    +   T+++L+ +L +KS +     ++   LK+++ +  ++F   K
Sbjct: 1440 NKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499

Query: 850  VMVEAYRRDATSKDQ-LISELKATRKR---LDSELKELRQELMQVHGEKRTAEAELSRLH 905
              +E  +     K+  L +ELK+   R   L+  + +   E+  ++   +    +    H
Sbjct: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH 1559

Query: 906  REVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQ 965
            +E+ Q  QH  +L     +  KE +E    L++      Q+ ++    E  KK++E +  
Sbjct: 1560 KELVQKLQHFQELGEEKDNRVKEAEEKILTLEN------QVYSMKAELETKKKELEHVNL 1613

Query: 966  EARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG 1025
              +    E K    RL S+  SA K  + K KA E  +  + ++L   +  KE    E  
Sbjct: 1614 SVKSKEEELKALEDRLESE--SAAKLAELKRKA-EQKIAAIKKQLLSQMEEKE----EQY 1666

Query: 1026 QLRAQGGSSDSSLALHER---IQALEAELQAV--SHSKTLL-EKELQEVIALTSQELEES 1079
            +   +   S+ +  L ER   +  LE +L++V  S S+TL+  +  + V A T QE  +S
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726

Query: 1080 R--------EKVLELEDELQESRGFRKKIKRLEESN-----------KKLALELEHEKGK 1120
            +        EK+  L+  L E     +++ + +E             ++  ++LEH + K
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786

Query: 1121 L----TGLGQSNAALREHNSILETALAKR-EADLVQLNLQ-----------VQAVLQRKE 1164
                 + +G     L E N      +A+  E +  + N+Q           VQ  LQ KE
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846

Query: 1165 EEDRQMKHLVQALQASLEKEKE-------KVNSLKEQVAAAKVEAGHNRRHFKAASLELS 1217
               + ++  ++ L + L ++KE       ++ S  E++ A +   G N+        EL 
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNK------PTELL 1900

Query: 1218 EVKKELQAKEHLVQ-----KLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
            E   E ++K HLVQ      ++A+ +DL+ +     +E  +   E+   +  L++L+K+ 
Sbjct: 1901 EENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE- 1959

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
                       QE+E LK E DQ ERE +  ++Q DL      K    L+QL++   ++L
Sbjct: 1960 ---------HQQELEILKKEYDQ-EREEKIKQEQEDLE----LKHNSTLKQLMREFNTQL 2005

Query: 1333 EMAQEDLSMTQKDKF---------MLQAKVSELKNNMKTLLQQNQQLKLDLRR 1376
               +++L MT K+           +L++   E    +K + +++  LK   +R
Sbjct: 2006 AQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058



 Score =  158 bits (399), Expect = 4e-38
 Identities = 245/1160 (21%), Positives = 497/1160 (42%), Gaps = 164/1160 (14%)

Query: 373  QDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMR--------LEGQLEAL 424
            +++  E +GE      +   ++       + QE +L+  KE ++        L  + EAL
Sbjct: 260  KEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEAL 319

Query: 425  SLEASQALKEKAELQAQLAALSTKLQAQVECSHS--SQQRQDSLSSEVDTLKQSCWDLER 482
              +  + L+E  +++    A  TKL  Q+  + +   Q  QD      +T +Q    LE 
Sbjct: 320  QEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM 379

Query: 483  AMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTA 542
               ++   L ++   + +   +L+  +E+ +R  A  E++++++ +   T    R+    
Sbjct: 380  KEEEIAQ-LRSRIKQMTTQGEELREQKEKSER--AAFEELEKALSTAQKTEEARRKLKAE 436

Query: 543  LQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVG 602
            +  Q++ ++          K S+ E  SLQ       Q+L+  ++  V +  + +  Q+ 
Sbjct: 437  MDEQIKTIE----------KTSEEERISLQ-------QELSRVKQEVVDVMKKSSEEQIA 479

Query: 603  QMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEA 662
            ++ +    E  + E   L+++L +T+ R  +E+ ++A +    E   + QE    + QE+
Sbjct: 480  KLQKLHEKELARKEQ-ELTKKL-QTREREFQEQMKVALEKSQSEYLKISQEK---EQQES 534

Query: 663  KTMVEEDLQRR--LEEFEGERERLQRMADS--------AASLEQQLEQVKLTLLQRDQQL 712
              + E +LQ++  L E E +   LQ+ A++         +SLE+ L++ K         L
Sbjct: 535  LALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHL 594

Query: 713  EALQQEH---LDLMKQLTLTQ-EALQSREQSL--DALQTHYDELQARLGELQGEAASRED 766
            EA + +H   + +M +   T+ E+L+ ++ +L  + LQ    + Q  + +L+ +    ++
Sbjct: 595  EAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKE 654

Query: 767  TICLLQNEKIILEAALQAAKSGK-EELDRGARRLEEGTEETSETLE---KLREELAIKSG 822
            T  LL++++II +A ++       E+LD     LE  + E SE L+   KL EEL++   
Sbjct: 655  T--LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712

Query: 823  QVEHLQQETAALKKQMQKIKEQFLQQKVM---VEAYRRDATSKDQLISELKATRKRLDSE 879
            Q + ++QE  A   + +   +Q +   +    V   R +   KDQ I++L+   K  D  
Sbjct: 713  QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ-INQLELLLKERDKH 771

Query: 880  LKE-------LRQELMQVHGEKRTAEAEL-------SRLHRE-------VAQVRQHMADL 918
            LKE       L  ++ +  GE + A A+L       S  H +       +AQ++Q + DL
Sbjct: 772  LKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831

Query: 919  EGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKM 978
            E       K+  E+E           Q   V    +A K Q+++L Q+  K  +E +QK+
Sbjct: 832  ETERILLTKQVAEVEA----------QKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV 881

Query: 979  RRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSL 1038
            + L     S   +++  +K  E    IL  +    L  +E    E+  L  +  + + S+
Sbjct: 882  KSLTQVYES---KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938

Query: 1039 AL---------------HERIQALEAELQAVSHSKTL-----LEKELQEVIALTSQELEE 1078
             +                E+++    E+Q     K L     L+KEL+      SQ+ ++
Sbjct: 939  HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998

Query: 1079 SREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSIL 1138
               K+LE+      S G    + RL E+N+K  +E       LT + +    L +  SI 
Sbjct: 999  FNAKMLEMAQ--ANSAGISDAVSRL-ETNQKEQIE------SLTEVHRRE--LNDVISIW 1047

Query: 1139 ETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAA 1198
            E  L ++  +L +++   +  LQ KE+E  ++K  +       E+  +++  LKE+    
Sbjct: 1048 EKKLNQQAEELQEIH---EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQ 1104

Query: 1199 KVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAEL 1258
                   +   K  S  ++ + ++         KL+A  + L++   K  +E    Q +L
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQD-------ETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157

Query: 1259 AEARAQLQLLQKQLDEQLSKQPVGNQEMENLK-------WEVDQKEREIQSLKQQLDLTE 1311
             E +   +  ++++ E  SK    ++E ++LK         ++ K  E + L ++L +  
Sbjct: 1158 VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQL 1217

Query: 1312 QQGRKELEGLQQLLQN------------VKSELEMAQEDLSMTQKDKFMLQAKVSELKNN 1359
                K+ E L +   N            + S +   Q   +  ++   +    VSEL+  
Sbjct: 1218 DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ 1277

Query: 1360 MKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPA 1419
            ++ L ++   L +  ++ A    +E + +  S        + +        +E L+    
Sbjct: 1278 LRQLTEEQNTLNISFQQ-ATHQLEEKENQIKSMKADIESLVTE--------KEALQKEGG 1328

Query: 1420 VSKEPLKNLNSCLQQLKQEM 1439
              ++      SC+ QLK+E+
Sbjct: 1329 NQQQAASEKESCITQLKKEL 1348



 Score =  155 bits (391), Expect = 4e-37
 Identities = 265/1159 (22%), Positives = 492/1159 (42%), Gaps = 178/1159 (15%)

Query: 394  VSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQV 453
            +SL+   +  ++E++ V+K+    E Q+  L     Q L EK EL  +   L+ KLQ + 
Sbjct: 453  ISLQQELSRVKQEVVDVMKKSS--EEQIAKL-----QKLHEK-ELARKEQELTKKLQTR- 503

Query: 454  ECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNN---DLQVAEE 510
            E     Q +     S+ + LK S    ++    L+ +   K A L  S N   DLQ   E
Sbjct: 504  EREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAE 563

Query: 511  QYQRLMAKVED-MQRSMLSKDNTVHDLRQQMTALQSQLQQ-----VQLERTTLTSKLKAS 564
             Y+  + ++E  +++S+    N   DL   + A +++  +     V+  +T L S LK  
Sbjct: 564  TYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES-LKHQ 622

Query: 565  QAEI--SSLQSVRQWYQQQLA-----LAQEARVRLQGE----MAHIQVGQMTQAGLLEHL 613
            Q  +    LQ ++Q YQ ++        QE    L+ +     AHI+         L+  
Sbjct: 623  QDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK 682

Query: 614  KLENVSLSQQLTETQHRSMKEKGRIAAQLQGI--EADMLDQEAAFMQIQEAKTMVEEDLQ 671
            + E  SLS +L+E     +K + ++  +L  +  + D + QE    ++ E K   ++ + 
Sbjct: 683  QTELESLSSELSEV----LKARHKLEEELSVLKDQTDKMKQELE-AKMDEQKNHHQQQVD 737

Query: 672  RRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQE 731
              ++E E   +R ++      +L+ Q+ Q++L L +RD+ L+  Q    +L   +  ++ 
Sbjct: 738  SIIKEHEVSIQRTEK------ALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791

Query: 732  ALQSREQSLDALQTH----------YDE----LQARLGELQGEA-----------ASRED 766
             LQ     LD  Q++          Y+E    LQ +L +L+ E            A ++D
Sbjct: 792  ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851

Query: 767  TICLLQNEKIILEAALQAAKSGKEELDRGAR--------RLEEGTEETSETLEKLREE-- 816
                L   KI ++  +Q  +    E+++  +        +LE+G +E  +T + L E+  
Sbjct: 852  VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911

Query: 817  --LAIKSGQ---VEHLQQETAALKKQMQKIKEQ----FLQQKVMVEAYRRDATSKDQLIS 867
              L ++ GQ   +E L Q+ +A +  +  + E+    F  Q+  +E  ++ A    + + 
Sbjct: 912  MILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK 971

Query: 868  ELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQH-MADLEGHLQSAQ 926
                 +K LD E K L++EL     E    E + +    E+AQ     ++D    L++ Q
Sbjct: 972  -----KKLLDQEAK-LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ 1025

Query: 927  KERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQ-------QEARKAITEQKQKMR 979
            KE+ E  T +   + +   ++++ E  + L +Q EELQ       QE  + + E KQK+ 
Sbjct: 1026 KEQIESLTEVHRRELN--DVISIWE--KKLNQQAEELQEIHEIQLQEKEQEVAELKQKIL 1081

Query: 980  RLGSDLTSAQKEMK-TKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSL 1038
              G +     KE+   K +  +    +    LQE L  K A    L Q        ++ L
Sbjct: 1082 LFGCEKEEMNKEITWLKEEGVKQDTTL--NELQEQLKQKSAHVNSLAQ-------DETKL 1132

Query: 1039 ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQES-RGFR 1097
              H  ++ LE +L       T L+++L E+  L     EE + KV EL  +L+ +   F+
Sbjct: 1133 KAH--LEKLEVDLNKSLKENTFLQEQLVELKMLA----EEDKRKVSELTSKLKTTDEEFQ 1186

Query: 1098 KKIKRLEESNKKLA-LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNL-Q 1155
                  E+SNK L    LE +K       Q +   ++  ++LE     +  +L+ ++  +
Sbjct: 1187 SLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA----KTNELINISSSK 1242

Query: 1156 VQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE 1215
              A+L R        +H    ++ +L  +   V+ L+ Q+     E       F+ A+ +
Sbjct: 1243 TNAILSRISH----CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQ 1298

Query: 1216 LSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQ 1275
            L E + ++++ +  ++ L  E + LQ +EG + Q+ A      +E  + +  L+K+L E 
Sbjct: 1299 LEEKENQIKSMKADIESLVTEKEALQ-KEGGNQQQAA------SEKESCITQLKKELSEN 1351

Query: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKE--LEGLQQLLQNVKSELE 1333
            ++   +  +E++  K E+    +++  L  QL  +     KE  +  L++     K EL 
Sbjct: 1352 INAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411

Query: 1334 MAQEDLSMT----QKDKFMLQAKV-------SELKNNMKTLLQQNQQLKLDLRRGAAKTR 1382
               +DLS       K+K     +V       SE K   ++   Q+Q    +L+       
Sbjct: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471

Query: 1383 KEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSL 1442
            KE   +    N                          + KE L   N     LK EM+  
Sbjct: 1472 KEAYEKDEQIN--------------------------LLKEELDQQNKRFDCLKGEMEDD 1505

Query: 1443 QRQMEEHALTVHESLSSWT 1461
            + +ME+    +   L S T
Sbjct: 1506 KSKMEKKESNLETELKSQT 1524



 Score =  123 bits (309), Expect = 1e-27
 Identities = 187/948 (19%), Positives = 402/948 (42%), Gaps = 127/948 (13%)

Query: 399  SAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHS 458
            + +E + ++ Q+ +E+  L    +  + +  +   +   ++A + +L T+ +A  +   +
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGN 1329

Query: 459  SQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAK 518
             QQ      S +  LK+   +   A+T ++  L+ K   ++S +  L     Q Q  +  
Sbjct: 1330 QQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387

Query: 519  VEDMQRSMLSKDNTVHDLRQQMTA----LQSQLQQVQLERTTLTSKLKASQAEISSLQSV 574
                  S+  K+  +  LR+Q       L  Q+Q +  +  TL      S+ +IS+L+ V
Sbjct: 1388 ------SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL------SKEKISALEQV 1435

Query: 575  RQW---YQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRS 631
              W   + +    AQ    + Q  +  +Q+ Q+       + K E ++L ++  + Q++ 
Sbjct: 1436 DDWSNKFSEWKKKAQSRFTQHQNTVKELQI-QLELKSKEAYEKDEQINLLKEELDQQNKR 1494

Query: 632  MK--------EKGRIAAQLQGIEADMLDQEAAFMQIQE---AKTMVEEDLQRRLEEFEGE 680
                      +K ++  +   +E ++  Q A  M++++    KT+  E L   L+ +  +
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQ 1554

Query: 681  RE--------RLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEA 732
            ++        +LQ   +     + ++++ +  +L  + Q+ +++ E     K+L     +
Sbjct: 1555 KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS 1614

Query: 733  LQSREQSLDALQTHYD-ELQARLGELQGEAASREDTICLLQNEKI--ILEAALQAAKSGK 789
            ++S+E+ L AL+   + E  A+L EL+ +A   E  I  ++ + +  + E   Q  K  +
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKA---EQKIAAIKKQLLSQMEEKEEQYKKGTE 1671

Query: 790  EELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQK 849
              L     +L+E   E     EKL+   +++S Q E L    +A        +E+   Q 
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLK---SVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728

Query: 850  VMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVA 909
             + + Y    +   + ++E +   +R+  E    ++E +  H E R    E   +  E A
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQE----KEETVSSHFEMRCQYQE-RLIKLEHA 1783

Query: 910  QVRQHM-ADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEAR 968
            + +QH    + GHLQ   +E+++  + + +   +KE      +A + L+   +++Q+  +
Sbjct: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ 1843

Query: 969  -KAITEQ--KQKMRRLGSDLTSAQK----EMKTKHKAYENAVGI------------LSRR 1009
             K +T Q  +QK++ L S L   ++    EM+     YE    +            L   
Sbjct: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEEN 1903

Query: 1010 LQEALAAKEAADAELGQLRAQGGSSDSSLALHERI-QALEAELQAVSHSKTLLEKELQEV 1068
             +E   +       L  + AQ    +  LA  ER  Q L  E+  +     +L KE Q+ 
Sbjct: 1904 TEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQE 1963

Query: 1069 IALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN 1128
            + +  +E ++ RE+                KIK+ +E      LEL+H           N
Sbjct: 1964 LEILKKEYDQEREE----------------KIKQEQED-----LELKH-----------N 1991

Query: 1129 AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
            + L++      T LA++E +L    + ++  + + +E + ++          LE  +E+ 
Sbjct: 1992 STLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAEL----------LESHQEET 2038

Query: 1189 NSLKEQVAAAKVEAGHNRRHFK----AASLELSEVKKELQAKEHLVQKLQAEADDLQIRE 1244
            N L +++A    +     + ++    A   E++   ++LQ +   +QK   +  + +   
Sbjct: 2039 NQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENP 2098

Query: 1245 GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWE 1292
            G  +  I + Q +LA+    +     +L EQ  ++ + N E    K+E
Sbjct: 2099 GNDNVTIMELQTQLAQKTTLIS--DSKLKEQEFREQIHNLEDRLKKYE 2144



 Score =  107 bits (267), Expect = 9e-23
 Identities = 170/759 (22%), Positives = 321/759 (42%), Gaps = 107/759 (14%)

Query: 735  SREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDR 794
            ++EQ +  L+     ++  L   +G+ +       +LQ EK  L+  L  ++      D+
Sbjct: 135  NKEQLIQRLR----RMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQ------DK 184

Query: 795  GARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE-TAALKKQMQKIKEQFLQQKVMVE 853
              RR+ E           LREEL +     +HLQ+E  A+L+++ Q I     Q  ++ +
Sbjct: 185  SLRRIAE-----------LREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQ 233

Query: 854  AYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQ 913
              R    + D L               K L Q  ++   E  T E         V +   
Sbjct: 234  RLRNGPMNVDVL---------------KPLPQ--LEPQAEVFTKEENPESDGEPVVEDGT 276

Query: 914  HMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITE 973
             +  LE   Q  +++ + ++   +++Q  KEQ   +T   EAL++Q++E  QE  K    
Sbjct: 277  SVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDL 336

Query: 974  QKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAEL----GQLRA 1029
               +  +L + L  A+  ++   +     +    R++ E L  KE   A+L     Q+  
Sbjct: 337  HMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396

Query: 1030 QG-----GSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL 1084
            QG         S  A  E ++   +  Q    ++  L+ E+ E I    +  EE R   +
Sbjct: 397  QGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER---I 453

Query: 1085 ELEDELQE---------SRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHN 1135
             L+ EL            +   ++I +L++ ++K   EL  ++ +LT   Q+    RE  
Sbjct: 454  SLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK---ELARKEQELTKKLQTRE--REFQ 508

Query: 1136 SILETALAKREAD---------------LVQLNLQVQAVLQRKEEEDRQMKHLVQA---- 1176
              ++ AL K +++               L +L LQ +A+L   E + R ++   +     
Sbjct: 509  EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568

Query: 1177 ---LQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKL 1233
               L++SLEK  ++ N  + +  A  +EA  N +H K  ++ + + K EL++ +H    L
Sbjct: 569  ILELESSLEKSLQE-NKNQSKDLAVHLEAEKN-KHNKEITVMVEKHKTELESLKHQQDAL 626

Query: 1234 QAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEV 1293
              E   LQ+ + ++  E+ + + E  E   +  L  K++  Q   + +  + +E L    
Sbjct: 627  WTE--KLQVLKQQYQTEMEKLR-EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL---- 679

Query: 1294 DQKEREIQSLKQQLDLTEQQGRK---ELEGLQQLLQNVKSELEM---AQEDLSMTQKDKF 1347
            D K+ E++SL  +L    +   K   EL  L+     +K ELE     Q++    Q D  
Sbjct: 680  DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739

Query: 1348 MLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPV-P 1406
            + + +VS ++   K L  Q  QL+L L+    + +   + +A   N    IK  +  +  
Sbjct: 740  IKEHEVS-IQRTEKALKDQINQLELLLKE---RDKHLKEHQAHVENLEADIKRSEGELQQ 795

Query: 1407 ASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQ 1445
            AS   ++ +   + + E  K     L QL+Q++  L+ +
Sbjct: 796  ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 109/582 (18%), Positives = 232/582 (39%), Gaps = 78/582 (13%)

Query: 373  QDQGQEVNGEVRSRRDSICS--------SVSLESSAAETQEEMLQVL---KEKMRLEGQL 421
            Q+ G+E +  V+   + I +           LE+   E +   L V    +E   LE +L
Sbjct: 1570 QELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL 1629

Query: 422  EALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLE 481
            E+ S      LK KAE   ++AA+  +L +Q+E     +Q +    S +  L     + E
Sbjct: 1630 ESESAAKLAELKRKAE--QKIAAIKKQLLSQME--EKEEQYKKGTESHLSELNTKLQERE 1685

Query: 482  RAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMA-------------------KVEDM 522
            R +    ++LE K  S+ SS ++  +     + + A                   K+  +
Sbjct: 1686 REV----HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741

Query: 523  QRSMLSKDNTVHDLRQQMTA-------LQSQLQQVQLERTTLTSKLKASQAEISSLQSVR 575
            QR++  K+  +  + Q+          ++ Q Q+  ++     +K    Q+ I  LQ   
Sbjct: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801

Query: 576  QWYQQQLALAQEARVRLQGEMAHIQVGQMTQ------AGLLEHLKLENVSLSQQLTETQH 629
            +   ++ +L     V  +G   +IQ  Q  +         L+  +L    L Q++ E   
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861

Query: 630  RSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEE------------- 676
              +++K     +++ + +     +A  +Q  + +    E L+   EE             
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQA--LQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919

Query: 677  -FEGERERLQRMADSAASLEQQLEQVKLTLLQRD-QQLEALQQEHLDLMKQLTLTQEALQ 734
              E +   L+     A   +Q+L + ++  LQ+D + L    Q+ L+++K+    +   +
Sbjct: 1920 NMEAQHNDLEFKLAGAEREKQKLGK-EIVRLQKDLRMLRKEHQQELEILKKEYDQEREEK 1978

Query: 735  SREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI--ILEAALQAAKSGKEEL 792
             +++  D    H   L+  + E   + A +E  + +   E I    E   +  +S +EE 
Sbjct: 1979 IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEET 2038

Query: 793  DRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQK--- 849
            ++  +++ E  ++   T ++  E L  +  ++    ++     +++QK  +Q L+Q+   
Sbjct: 2039 NQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENP 2098

Query: 850  ----VMVEAYRRDATSKDQLISELKATRKRLDSELKELRQEL 887
                V +   +     K  LIS+ K   +    ++  L   L
Sbjct: 2099 GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRL 2140



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/268 (21%), Positives = 113/268 (42%), Gaps = 38/268 (14%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKM------RLE 418
            L  A  E Q  G+E+   VR ++D       L     E Q+E L++LK++       +++
Sbjct: 1932 LAGAEREKQKLGKEI---VRLQKD-------LRMLRKEHQQE-LEILKKEYDQEREEKIK 1980

Query: 419  GQLEALSLEASQALKE-KAELQAQLAALSTKLQAQVECSHSSQQR---------QDSLSS 468
             + E L L+ +  LK+   E   QLA    +L+  ++ + +  Q          Q+  + 
Sbjct: 1981 QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQ 2040

Query: 469  EVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLS 528
             +  + +   DL+R     + +L+A+   + +   DLQ   E+ Q+        Q+ +  
Sbjct: 2041 LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK------KYQQKLEQ 2094

Query: 529  KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ--AEISSLQSVRQWYQQQLALAQ 586
            ++N  +D    +T ++ Q Q  Q       SKLK  +   +I +L+   + Y++ +    
Sbjct: 2095 EENPGND---NVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATT 2151

Query: 587  EARVRLQGEMAHIQVGQMTQAGLLEHLK 614
                   G + H  V    +    E+L+
Sbjct: 2152 VGTPYKGGNLYHTDVSLFGEPTEFEYLR 2179



 Score = 38.9 bits (89), Expect = 0.038
 Identities = 70/408 (17%), Positives = 159/408 (38%), Gaps = 49/408 (12%)

Query: 373  QDQGQEVNGEVRSRRDSICSS----VSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEA 428
            Q  GQE    V S  +  C      + LE + A+  E+   +   +  LE + +  SL  
Sbjct: 1753 QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIV 1812

Query: 429  SQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDT---LKQSCWDLERAMT 485
            +Q ++++             +QA+    +     Q +L  +  T   L+Q   +L+  + 
Sbjct: 1813 AQHVEKEGG--------KNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLV 1864

Query: 486  DLQNMLEAKNASLASSNNDLQVAEEQYQR------LMAKVEDMQRSMLSKDNTVHDLRQQ 539
              + +   +   L S    LQ  ++   R      L    E+  +S L +   + ++  Q
Sbjct: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924

Query: 540  MTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALA-----QEARVRLQG 594
               L+ +L   + E+  L  ++   Q +   L+ +R+ +QQ+L +      QE   +++ 
Sbjct: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKD---LRMLRKEHQQELEILKKEYDQEREEKIKQ 1981

Query: 595  EMAHIQVGQ-MTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ- 652
            E   +++    T   L+     +     Q+L  T   ++ +   + A+L     +  +Q 
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL 2041

Query: 653  ------------------EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL 694
                              E      +E  T    DLQ +LEE + + ++     ++  + 
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGND 2101

Query: 695  EQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDA 742
               + +++  L Q+   +   + +  +  +Q+   ++ L+  E+++ A
Sbjct: 2102 NVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYA 2149


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  171 bits (432), Expect = 6e-42
 Identities = 238/1085 (21%), Positives = 467/1085 (43%), Gaps = 125/1085 (11%)

Query: 400  AAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSS 459
            +AET++EM  + +E  R++  LE       +  ++   L  +   L  ++QA+ +  + +
Sbjct: 844  SAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDA 903

Query: 460  QQRQDSLSSEVDTLKQSCWDLERAMTDLQNM---LEAKNASLASSNNDLQVAEEQYQRLM 516
            ++R D L      L+    ++   + D + M   L AK   L    ++L+   +  +  +
Sbjct: 904  EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTL 963

Query: 517  AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTL-------TSKLKASQAEIS 569
            AKVE   +   + +N V +L ++M  L   + ++  E+  L          L+  + +++
Sbjct: 964  AKVE---KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN 1020

Query: 570  SLQSVRQWYQQQL-----ALAQEARVRLQGEMAHIQVG---QMTQAGLLEHLKLENVSLS 621
            SL   +   +QQ+     +L QE +VR+  E A  ++    ++TQ  +++   LEN  L 
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD---LENDKL- 1076

Query: 622  QQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGER 681
                + + +  K++  I  Q   IE    D++   +Q+Q+     +  ++   EE E ER
Sbjct: 1077 ----QLEEKLKKKEFDINQQNSKIE----DEQVLALQLQKKLKENQARIEELEEELEAER 1128

Query: 682  ERLQRMADSAASLEQQLEQVKLTLLQ----RDQQLEALQQEHLDLMKQLTLTQEALQSRE 737
                ++    + L ++LE++   L +       Q+E  ++   +  K     +EA    E
Sbjct: 1129 TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1188

Query: 738  QSLDALQTHYDELQARLGE----LQGEAASREDTICLLQNEKIILEAALQAAKSGKEELD 793
             +  AL+  + +  A LGE    LQ      E      + E   + + ++     K  L+
Sbjct: 1189 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1248

Query: 794  RGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVE 853
            + +R LE+   E    LE+ +  L   + Q   LQ E   L +Q+++ KE  + Q    +
Sbjct: 1249 KVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE-KEALISQLTRGK 1307

Query: 854  -AYRRDATSKDQLISELKATRKRLDSELKELRQE---LMQVHGEKRTAEAELSRL----H 905
             +Y +      + + E    +  L   L+  R +   L + + E+  A+AEL R+    +
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367

Query: 906  REVAQVR----------------------QHMADLEGHLQSAQKERDEMETHLQSLQFDK 943
             EVAQ R                      Q + D E  +++   +   +E     LQ + 
Sbjct: 1368 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI 1427

Query: 944  EQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKE---MKTKHKAYE 1000
            E ++   E + A    +++ Q+   K + E KQK     S+L S+QKE   + T+    +
Sbjct: 1428 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487

Query: 1001 NAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTL 1060
            NA       L+      +    E+  L  Q G    ++           EL+ V     +
Sbjct: 1488 NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV----------HELEKVRKQLEV 1537

Query: 1061 LEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK 1120
             + ELQ  +      LE    K+L  + E  + +   +  ++L E ++++     + +  
Sbjct: 1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA--EIERKLAEKDEEMEQAKRNHQRV 1595

Query: 1121 LTGLGQS-NAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQAL-- 1177
            +  L  S +A  R  N +L     K E DL ++ +Q+    +   E  +Q+K L   L  
Sbjct: 1596 VDSLQTSLDAETRSRNEVLRVK-KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1654

Query: 1178 -QASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFK----AASLELSEVKKELQAKEHL--- 1229
             Q  L+      + LKE +A   VE  +N    +     A +E +E  ++L  +E +   
Sbjct: 1655 TQIQLDDAVRANDDLKENIAI--VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETS 1712

Query: 1230 --VQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQ----------LDEQLS 1277
              VQ L ++   L  ++ K   ++ Q Q+E+ EA  + +  +++          + E+L 
Sbjct: 1713 ERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1772

Query: 1278 KQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQ----QGRKELEGLQQLLQNVKSELE 1333
            K+   +  +E +K  ++Q    I+ L+ +LD  EQ     G+K+L+ L+  ++ ++ ELE
Sbjct: 1773 KEQDTSAHLERMKKNMEQ---TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELE 1829

Query: 1334 MAQEDLSMTQKDKFMLQAKVSEL----KNNMKTLLQ-QNQQLKLDLRRGAAKTRKEPKGE 1388
              Q+  + + K     + ++ EL    + + K LL+ Q+   KL L+  A K + E   E
Sbjct: 1830 AEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1889

Query: 1389 ASSSN 1393
             +++N
Sbjct: 1890 QANTN 1894



 Score =  157 bits (396), Expect = 9e-38
 Identities = 213/928 (22%), Positives = 416/928 (44%), Gaps = 136/928 (14%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEAL 424
            LQ    E+Q + +E+  E+ + R +      L S  +   EE+ +      RLE    A 
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE------RLEEAGGAT 1159

Query: 425  SLEASQALKEKAELQAQLAAL-STKLQAQVECSHSSQQRQDS---LSSEVDTLKQSCWDL 480
            S++     K +AE Q     L    LQ +   +   ++  DS   L  ++D L++     
Sbjct: 1160 SVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQR----- 1214

Query: 481  ERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQM 540
                  ++  LE + +      +D+    EQ  +  A +E + R++   ++  ++ R ++
Sbjct: 1215 ------VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL---EDQANEYRVKL 1265

Query: 541  TALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQ 600
               Q  L     + TT  +KL+    E++     RQ  +++  ++Q  R    G++++ Q
Sbjct: 1266 EEAQRSLN----DFTTQRAKLQTENGELA-----RQLEEKEALISQLTR----GKLSYTQ 1312

Query: 601  VGQMTQAGLLEHLKLENVSLSQQLTETQH------RSMKEKGRIAAQLQGIEADMLDQEA 654
              +  +  L E  K +N +L+  L   +H         +E+    A+LQ +         
Sbjct: 1313 QMEDLKRQLEEEGKAKN-ALAHALQSARHDCDLLREQYEEETEAKAELQRV------LSK 1365

Query: 655  AFMQIQEAKTMVEEDLQRRLEEFEGERERL-QRMADSAASLEQQLEQVKLTLLQRDQQLE 713
            A  ++ + +T  E D  +R EE E  +++L QR+ D+    E+ +E V       ++   
Sbjct: 1366 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA----EEAVEAVNAKCSSLEKTKH 1421

Query: 714  ALQQEHLDLM---KQLTLTQEALQSREQSLDAL----QTHYDELQARLGELQGEAASRED 766
             LQ E  DLM   ++      AL  ++++ D +    +  Y+E Q+ L   Q EA S   
Sbjct: 1422 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1481

Query: 767  TICLLQN--EKII--LEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSG 822
             +  L+N  E+ +  LE   +  K+ +EE+     +L EG +   E LEK+R++L ++  
Sbjct: 1482 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE-LEKVRKQLEVEKL 1540

Query: 823  QVEH-LQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKR------ 875
            +++  L++  A+L+ +  KI    L+   +     R    KD+ + + K   +R      
Sbjct: 1541 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQ 1600

Query: 876  --LDSELKELRQELMQV----HGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
              LD+E +  R E+++V     G+    E +LS  +R  A+ ++ +  L+  L+  Q + 
Sbjct: 1601 TSLDAETRS-RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1659

Query: 930  DEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ 989
            D+       L   KE +  V   N  L+ ++EEL     +A+ EQ ++ R+L     + Q
Sbjct: 1660 DDAVRANDDL---KENIAIVERRNNLLQAELEEL-----RAVVEQTERSRKL-----AEQ 1706

Query: 990  KEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEA 1049
            + ++T  +     V +L  +    +  K+  +++L QL+     S+   A+ E   A E 
Sbjct: 1707 ELIETSER-----VQLLHSQNTSLINQKKKMESDLTQLQ-----SEVEEAVQECRNAEEK 1756

Query: 1050 ELQAVSHSKTLLE--KELQEVIALTSQELEESREKVLELEDELQES-----RGFRKKIKR 1102
              +A++ +  + E  K+ Q+  A   +  +   + + +L+  L E+     +G +K++++
Sbjct: 1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816

Query: 1103 LEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR 1162
            LE   ++L  ELE E              ++ N+     + K E  + +L  Q       
Sbjct: 1817 LEARVRELEGELEAE--------------QKRNAESVKGMRKSERRIKELTYQT------ 1856

Query: 1163 KEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKE 1222
              EED+  K+L++ LQ  ++K + KV + K Q   A+ +A  N   F+    EL E ++ 
Sbjct: 1857 --EEDK--KNLLR-LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1911

Query: 1223 LQAKEHLVQKLQAEADDLQIREGKHSQE 1250
                E  V KL+A++ D+  ++  H +E
Sbjct: 1912 ADIAESQVNKLRAKSRDIGAKQKMHDEE 1939



 Score =  155 bits (391), Expect = 4e-37
 Identities = 229/1068 (21%), Positives = 447/1068 (41%), Gaps = 136/1068 (12%)

Query: 371  EHQDQGQEVNGEVRSRRDSICSSVS-LESSAAETQEEMLQVLKEKMRLEGQLEALSLEAS 429
            E  +  +E+N E+ +++  +    S L+    + +  + +V KEK   E +++ L+ E +
Sbjct: 926  ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985

Query: 430  -------QALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSC----- 477
                   +  KEK  LQ         LQ + +  +S  + +  L  +VD L+ S      
Sbjct: 986  GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKK 1045

Query: 478  --WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQR-------LMAKVED------- 521
               DLERA   L+  L+    S+    ND    EE+ ++         +K+ED       
Sbjct: 1046 VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ 1105

Query: 522  MQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLK--ASQAEISSLQSVRQWYQ 579
            +Q+ +      + +L +++ A ++   +V+  R+ L+ +L+  + + E +   +  Q   
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1165

Query: 580  QQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQ---HRSMKEKG 636
             +   A+  ++R   E A +Q  + T A L +        L +Q+   Q    +  KEK 
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1224

Query: 637  RIAAQLQGIEADMLDQEAAFMQIQEAKTMVE----------EDLQRRLEEFEGERERLQ- 685
                +L  + ++M     A   +++    +E          E+ QR L +F  +R +LQ 
Sbjct: 1225 EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT 1284

Query: 686  ---RMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDA 742
                +A      E  + Q+    L   QQ+E L+++  +  K       ALQS     D 
Sbjct: 1285 ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL 1344

Query: 743  LQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAK-SGKEELDRGARRLEE 801
            L+  Y+E      ELQ                +++ +A  + A+   K E D   R    
Sbjct: 1345 LREQYEEETEAKAELQ----------------RVLSKANSEVAQWRTKYETDAIQR---- 1384

Query: 802  GTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATS 861
             TEE  E  +KL + L      VE +  + ++L+K   +++ +   + +MV+  R +A +
Sbjct: 1385 -TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI--EDLMVDVERSNAAA 1441

Query: 862  K---------DQLISELKATRKRLDSELKELRQELMQVHGE----KRTAEAELSRLH--- 905
                      D++++E K   +   SEL+  ++E   +  E    K   E  L  L    
Sbjct: 1442 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1501

Query: 906  REVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDK-EQMVAVTEANEALKKQ---IE 961
            RE   +++ ++DL   L    K   E+E   + L+ +K E   A+ EA  +L+ +   I 
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561

Query: 962  ELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAAD 1021
              Q E  +   E ++K+     ++  A++  +    + + ++   +R   E L  K+  +
Sbjct: 1562 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621

Query: 1022 AELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
             +L ++  Q          H    A EA+ Q  S    L + ++Q   A+ + +  +   
Sbjct: 1622 GDLNEMEIQ--------LSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1673

Query: 1082 KVLELEDEL--QESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILE 1139
             ++E  + L   E    R  +++ E S K    EL     ++  L   N +L        
Sbjct: 1674 AIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--- 1730

Query: 1140 TALAKREADLVQLNLQV-QAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNS-----LKE 1193
                K E+DL QL  +V +AV + +  E++  K +  A   + E +KE+  S     +K+
Sbjct: 1731 ----KMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1786

Query: 1194 QVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQ 1253
             +     +  H  R  +A  + L   KK+LQ  E  V++L+ E +  Q R  +  + + +
Sbjct: 1787 NMEQTIKDLQH--RLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRK 1844

Query: 1254 FQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQ 1313
             +  + E   Q +  +K L             +++L   VD+ + ++++ K+Q +  E+Q
Sbjct: 1845 SERRIKELTYQTEEDKKNL-----------LRLQDL---VDKLQLKVKAYKRQAEEAEEQ 1890

Query: 1314 GRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMK 1361
                L   ++    V+ EL+ A+E   + +     L+AK  ++    K
Sbjct: 1891 ANTNLSKFRK----VQHELDEAEERADIAESQVNKLRAKSRDIGAKQK 1934



 Score =  150 bits (378), Expect = 1e-35
 Identities = 224/1139 (19%), Positives = 464/1139 (40%), Gaps = 146/1139 (12%)

Query: 460  QQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNND---LQVAEEQYQRLM 516
            ++ +D   S + T  Q+    +    + + ++E ++A L    N    + V    + +L 
Sbjct: 776  EEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLY 835

Query: 517  AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
             K++ + +S    +  +  ++++   ++  L++ +  R  L  K+ +   E + LQ   Q
Sbjct: 836  FKIKPLLKSA-ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ 894

Query: 577  WYQQQLALAQEA-------RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTE--- 626
              Q  L  A+E        +++L+ ++  +      +  +   L  +   L  + +E   
Sbjct: 895  AEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKK 954

Query: 627  -------TQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
                   T  +  KEK     +++ +  +M   +    ++ + K  ++E  Q+ L++ + 
Sbjct: 955  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQV 1014

Query: 680  ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQS 739
            E +++  ++ S   LEQQ++ ++ +L Q  +    L++    L   L LTQE++   E  
Sbjct: 1015 EEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN- 1073

Query: 740  LDALQTHYDELQARLGELQGEAASREDTICLLQNEKII---------LEAALQAAKSGKE 790
             D LQ      +      Q  +   ++ +  LQ +K +         LE  L+A ++ + 
Sbjct: 1074 -DKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARA 1132

Query: 791  ELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKV 850
            ++++    L    EE SE LE   E     S Q+E  ++  A  +K  + ++E  LQ + 
Sbjct: 1133 KVEKLRSDLSRELEEISERLE---EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1189

Query: 851  MVEAYRR----DATSKDQLISELKATRKRLDSELKELRQELMQVHGE------------- 893
               A R+          + I  L+  +++L+ E  E + EL  V                
Sbjct: 1190 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1249

Query: 894  -KRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQM----VA 948
              RT E + +    ++ + ++ + D        Q E  E+   L+  +    Q+    ++
Sbjct: 1250 VSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLS 1309

Query: 949  VTEANEALKKQIEE--------------------LQQEARKAITEQKQKMRRLGSDLTSA 988
             T+  E LK+Q+EE                    L +E  +  TE K +++R+ S   S 
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369

Query: 989  QKEMKTKHKA--------YENAVGILSRRLQEALAAKEAADAELGQL-----RAQGGSSD 1035
              + +TK++          E A   L++RLQ+A  A EA +A+   L     R Q    D
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429

Query: 1036 SSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLEL--------- 1086
              + + ER  A  A L     +   +  E ++    +  ELE S+++   L         
Sbjct: 1430 LMVDV-ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1488

Query: 1087 --EDELQESRGFRKKIKRLEE-----------------SNKKLALELEHEKGKLTGLGQS 1127
              E+ L+    F+++ K L+E                   +K+  +LE EK +L    + 
Sbjct: 1489 AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEE 1548

Query: 1128 NAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMK----HLVQALQASLEK 1183
              A  EH    E  + + + +  Q+  +++  L  K+EE  Q K     +V +LQ SL+ 
Sbjct: 1549 AEASLEHE---EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDA 1605

Query: 1184 EKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIR 1243
            E    N +       + +          A+   +E +K++++ + L++  Q + DD    
Sbjct: 1606 ETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1665

Query: 1244 EGKHSQEIA-------QFQAELAEARA---QLQLLQKQLDEQLSKQPVGNQEMENLKWEV 1293
                 + IA         QAEL E RA   Q +  +K  +++L +     Q + +    +
Sbjct: 1666 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1725

Query: 1294 DQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKV 1353
              ++++++S   QL    ++  +E    ++  +   ++  M  E+L   Q     L+   
Sbjct: 1726 INQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1785

Query: 1354 SELKNNMKTL---LQQNQQL-----KLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPV 1405
              ++  +K L   L + +Q+     K  L++  A+ R E +GE  +        +     
Sbjct: 1786 KNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR-ELEGELEAEQKRNAESVKGMRK 1844

Query: 1406 PASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLE 1464
                ++EL        K+ L  L   + +L+ ++ + +RQ EE     + +LS +  ++
Sbjct: 1845 SERRIKELTYQTEE-DKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1902



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 176/909 (19%), Positives = 355/909 (39%), Gaps = 147/909 (16%)

Query: 144  LEKEEQVRLQARKWLEE---QLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPR 200
            +E E+ + LQ +K L+E   ++++   + + ER+++ A   +L S L  EL    E L  
Sbjct: 1096 IEDEQVLALQLQKKLKENQARIEELEEELEAERTAR-AKVEKLRSDLSRELEEISERLEE 1154

Query: 201  ASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSG 260
            A                      G+  +     +K+ ++  K+R   +  T    A    
Sbjct: 1155 AG---------------------GATSVQIEMNKKREAEFQKMRRDLEEATLQHEA---- 1189

Query: 261  GNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSSY 320
                    T  +L++  + +   V+E+    D   R++       S  +++ +D  S+  
Sbjct: 1190 --------TAAALRKKHADS---VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238

Query: 321  SSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVN 380
                 +     +S+T+  Q   Y V  +E    +L  F + +  LQ             N
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQR-SLNDFTTQRAKLQTE-----------N 1286

Query: 381  GEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKE------ 434
            GE+  + +   + +S  +    +  + ++ LK ++  EG+ +     A Q+ +       
Sbjct: 1287 GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR 1346

Query: 435  ---------KAELQAQLAALSTKL-QAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAM 484
                     KAELQ  L+  ++++ Q + +    + QR + L      L Q   D E A+
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV 1406

Query: 485  TDLQ---NMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMT 541
              +    + LE     L +   DL V  E+     A ++  QR+    D  + + +Q+  
Sbjct: 1407 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNF---DKILAEWKQKYE 1463

Query: 542  ALQSQLQQVQLERTTLTSKL-KASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQ 600
              QS+L+  Q E  +L+++L K   A   SL+ +  + ++   L +E    L  ++    
Sbjct: 1464 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS-DLTEQLGEGG 1522

Query: 601  VGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIA-AQLQ------GIEADMLDQE 653
                    + + L++E + L   L E +     E+G+I  AQL+       IE  + +++
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1582

Query: 654  AAFMQIQEAKTMVEEDLQRRLEEFEGERERLQR----MADSAASLEQQLEQVKLTLLQRD 709
                Q +     V + LQ  L+     R  + R    M      +E QL        +  
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1642

Query: 710  QQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQG---------- 759
            +Q+++LQ    D   QL     A    ++++  ++   + LQA L EL+           
Sbjct: 1643 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK 1702

Query: 760  ----EAASREDTICLLQ-------NEKIILEAALQAAKSGKEELDRGARRLEEGT----- 803
                E     + + LL        N+K  +E+ L   +S  EE  +  R  EE       
Sbjct: 1703 LAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAIT 1762

Query: 804  ------------EETSETLEKLREELAIKSGQVEHLQQETAAL-----KKQMQKIKEQFL 846
                        ++TS  LE++++ +      ++H   E   +     KKQ+QK++ +  
Sbjct: 1763 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV- 1821

Query: 847  QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHR 906
                             +L  EL+A +KR    +K +R+   ++       E +   L R
Sbjct: 1822 ----------------RELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 1865

Query: 907  EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
                V +    ++ + + A++  ++  T+L   +  + ++    E  +  + Q+ +L+ +
Sbjct: 1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925

Query: 967  ARKAITEQK 975
            +R    +QK
Sbjct: 1926 SRDIGAKQK 1934


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  170 bits (431), Expect = 8e-42
 Identities = 276/1338 (20%), Positives = 549/1338 (41%), Gaps = 196/1338 (14%)

Query: 297  LENTSLAG-DSVSEVDGNDSD---SSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPA 352
            L + SL G D+   + G +     S  ++S +T  T       +  +D    +N   +  
Sbjct: 1650 LSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLN---LDI 1706

Query: 353  DTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSS---------------VSLE 397
            + + +  ++K   + +  +  D   E  GE +++  S C S               +  +
Sbjct: 1707 EKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQ 1766

Query: 398  SSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSH 457
                  Q  + +   E +RL   +E    +    L E  EL ++L     +L  ++E   
Sbjct: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI 1826

Query: 458  SSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRL-- 515
              ++    L  E   L +    LE    D Q +L+    S    N+DL++  ++  R   
Sbjct: 1827 ELEKIVGELKKENSDLSEK---LEYFSCDHQELLQRVETS-EGLNSDLEMHADKSSREDI 1882

Query: 516  ---MAKVEDMQRS-MLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSL 571
               +AKV D  +   L  +N +  +R +  +++ +   ++ +   + ++    + +  + 
Sbjct: 1883 GDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENK 1942

Query: 572  QSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLK----------------- 614
            Q V    +++L++    R +L+GE+  +         L E +K                 
Sbjct: 1943 QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002

Query: 615  -------LENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADM-------LDQEAAFMQIQ 660
                    E   L Q L+      +K+K  +  +LQ +E D         + E    Q+ 
Sbjct: 2003 QVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN 2062

Query: 661  EAKTMV---EEDLQRRLEEFEGERERLQRMADSA-----------ASLEQQLEQVKLTLL 706
            + K ++    E LQ RL E + E+  + +  ++A           +S ++++ Q++  + 
Sbjct: 2063 KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE 2122

Query: 707  QRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASRED 766
            +   ++EA      D  KQL +  E L+ RE+  D+L+   + L+    ELQ    ++E 
Sbjct: 2123 KLRVRIEA------DEKKQLHIA-EKLKERERENDSLKDKVENLER---ELQMSEENQEL 2172

Query: 767  TICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEH 826
             I   +N K    A ++  K+  EE+ R  +  E          E L +++  K GQ+  
Sbjct: 2173 VILDAENSK----AEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE 2228

Query: 827  LQQETAALKKQMQKIKEQFLQ----QKVMVEAYRRDATSKDQLISEL-------KATRKR 875
            L +  ++ K  +++ ++  +Q     K  VE  +      ++ ++ L       KAT + 
Sbjct: 2229 LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS 2288

Query: 876  LDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQ--HMADL-EGHLQSAQKERDEM 932
            LD  ++E  Q    +   +   EA+  +    + Q+++  H ADL +G +++ ++E +  
Sbjct: 2289 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2348

Query: 933  ETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEAR----KAITEQKQKMRRLGSDLTSA 988
             T+ +    + E      E    LK +IE + Q  R      +T + +K   L ++L   
Sbjct: 2349 RTNQEHAALEAENSKGEVET---LKAKIEGMTQSLRGLELDVVTIRSEK-ENLTNELQKE 2404

Query: 989  QK---EMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLA-LHERI 1044
            Q+   E++  + ++EN   IL  + QE +  KE +   +  L+ Q    +  +A LH   
Sbjct: 2405 QERISELEIINSSFEN---ILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461

Query: 1045 QALEAELQAVSHSKTLLEKELQEV-----------IALTS-------------QELEESR 1080
            +A +A+ Q +S     LE E  ++           I L S             Q+LE+  
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521

Query: 1081 EKVLELEDELQESRGFRKKIKRLE-------ESN---KKLALELEHEKGKLTGLGQSNAA 1130
            E++  L++++Q+      K+ ++E       E N   + L +ELE    K+  L   NA+
Sbjct: 2522 EEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQ---KIQVLQSKNAS 2578

Query: 1131 LREHNSILETALAKREADLVQLNL-------QVQAVLQRKEEEDRQMKHLVQALQASLEK 1183
            L++   +L+++    E +L    +       +V  +  ++ E  R+M  + Q      E+
Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638

Query: 1184 EKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIR 1243
               + N L  ++     E   ++   K  +LE SE+KK L      + K Q E      +
Sbjct: 2639 LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC----MHKDQVE------K 2688

Query: 1244 EGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSL 1303
            EGK  +EIA++Q  L EA  + Q L    ++Q         E++  + ++  KE  + S 
Sbjct: 2689 EGKVREEIAEYQLRLHEAEKKHQALLLDTNKQY------EVEIQTYREKLTSKEECLSSQ 2742

Query: 1304 KQQLDL---TEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNM 1360
            K ++DL   ++++    L+   Q+L+ +K       + ++  +K+    Q K+  L  + 
Sbjct: 2743 KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSC 2802

Query: 1361 KTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAV 1420
            K L ++ + L+ +L +  A   K+  G    +      K+ +       L+E L      
Sbjct: 2803 KQLEEEKEILQKELSQLQAAQEKQKTGTVMDT------KVDELTTEIKELKETLEEKTKE 2856

Query: 1421 SKEPLKNLNSCL---QQLKQEMDSLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHA 1477
            + E L    S L   ++L++  + L+ Q+        +  S  +PL      PV PG   
Sbjct: 2857 ADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPL----LGPVVPGPSP 2912

Query: 1478 GPRGDPQRHSQSRASKEG 1495
             P    +R S  +    G
Sbjct: 2913 IPSVTEKRLSSGQNKASG 2930



 Score =  145 bits (367), Expect = 2e-34
 Identities = 258/1235 (20%), Positives = 511/1235 (41%), Gaps = 218/1235 (17%)

Query: 377  QEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQAL--KE 434
            QE N   +    +    V    S  E   + L+ L+EKM  +G ++   ++  + L   E
Sbjct: 1532 QEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1591

Query: 435  KAELQA-QLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEA 493
            + EL   +   LS   Q Q + +  + + +  L++E    +Q   +LE A   LQ  L+ 
Sbjct: 1592 RQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQG-LDL 1650

Query: 494  KNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLE 553
             + SL   + +  +   Q +     +     S  ++    HD+ Q       Q   + +E
Sbjct: 1651 SSRSLLGIDTEDAI---QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIE 1707

Query: 554  RTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHL 613
            + T T  +K +  E S  QS    Y+       +       E++      +     L + 
Sbjct: 1708 KITETGAVKPT-GECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQ 1766

Query: 614  K-LENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEA--AFMQIQEAKTMVEEDL 670
            + + N+ L  ++ ET + +++    I  + + +E+ + + +   + + +QE + M + + 
Sbjct: 1767 EDIHNLQL--RVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA 1824

Query: 671  QRRLEEFEGERERLQRMADSAASLEQQLEQVKLT---LLQRDQQLEALQQEHLDLMKQLT 727
               LE+  GE ++        + L ++LE        LLQR +  E L  + L++    +
Sbjct: 1825 CIELEKIVGELKK------ENSDLSEKLEYFSCDHQELLQRVETSEGLNSD-LEMHADKS 1877

Query: 728  LTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
              ++   +  +  D+ +  + +++  L  ++ E AS       +++E + LEA L+  ++
Sbjct: 1878 SREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS-------IEHEALYLEADLEVVQT 1930

Query: 788  GKEELDRGARRLEEGTEETSETLEKLREELAIKS-------GQVEHLQQETAALKKQMQK 840
             K         LE+  E   + +  L EEL++ +       G+++ + ++T AL +  +K
Sbjct: 1931 EK-------LCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEK 1983

Query: 841  IKEQFLQQKV-------MVEAYRRDATSKDQL-------ISELKATRKRLDSELK----- 881
            +KE+  + +         ++    +   K +L       +SEL   +  L  +L+     
Sbjct: 1984 MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKD 2043

Query: 882  ---------ELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEM 932
                     EL  ++ Q++ EK     E   L   +++      ++   L++A  E+ E 
Sbjct: 2044 SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEF 2103

Query: 933  ETHLQS------------------LQFDKEQMVAVTE-------ANEALKKQIEELQQEA 967
               L S                  ++ D+++ + + E        N++LK ++E L++E 
Sbjct: 2104 ALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL 2163

Query: 968  RKAITEQKQKMRRLGSDLTSAQKE-MKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
            +  ++E+ Q++  L ++ + A+ E +KT+ +    ++ +    L    + KE    ++ +
Sbjct: 2164 Q--MSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221

Query: 1027 LRAQGGSSDSSLALHERI--QALEAELQAVSHSKTLLE------KELQEVIALT--SQEL 1076
             + Q    D  L+  + +  +  +AE+Q    SKT +E      KEL E +A     QE+
Sbjct: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEI 2281

Query: 1077 EESREKVLE--LEDELQESRGFRKKIKRLEESNKK------------------------- 1109
             ++ E+ L+  +E+E Q      K   RLE   KK                         
Sbjct: 2282 MKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENL 2341

Query: 1110 -------------LALELEHEKG-------KLTGLGQSNAAL-------REHNSILETAL 1142
                          ALE E+ KG       K+ G+ QS   L       R     L   L
Sbjct: 2342 ERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNEL 2401

Query: 1143 AK---READLVQLNLQVQAVLQRKEEEDRQMKH----LVQALQASLEKEKEKVNSLKEQV 1195
             K   R ++L  +N   + +LQ KE+E  QMK      ++ LQ  L++  E+V +L    
Sbjct: 2402 QKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461

Query: 1196 AAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDL--QIREGKHSQEIAQ 1253
             A K +  +     +   LE +++ + L   ++    LQ+  + L  ++ +GK  Q++ +
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK--QKLEK 2519

Query: 1254 FQAELAEARAQLQ--------LLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQ 1305
               E++  + Q+Q        L Q + + QL K+   N E+ NL  E++QK + +QS   
Sbjct: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQ--NLELRNLTVELEQKIQVLQSKNA 2577

Query: 1306 QLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQ 1365
             L  T       LE LQ   +N+++ELE+ + D     +    + AK +EL+  M  + Q
Sbjct: 2578 SLQDT-------LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQ 2630

Query: 1366 QNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPL 1425
            +  +L+ +L    +  +    GE                    LLEE+       SK+ L
Sbjct: 2631 KTAELQEEL----SGEKNRLAGELQ-----------------LLLEEI-----KSSKDQL 2664

Query: 1426 KNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSW 1460
            K L     +LK+ +D + +   E    V E ++ +
Sbjct: 2665 KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEY 2699



 Score =  131 bits (329), Expect = 6e-30
 Identities = 193/1027 (18%), Positives = 421/1027 (40%), Gaps = 125/1027 (12%)

Query: 409  QVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSS 468
            + L++   LEGQL+ L        KEK + Q QL +L   LQ Q +   + +    +L  
Sbjct: 15   RALQKIQELEGQLDKLK-------KEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKR 67

Query: 469  EVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLS 528
            E   L + C  LE+    + + L+ K + +      L   ++Q       +E +++ +  
Sbjct: 68   ENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQ-------IEKLEQELKR 120

Query: 529  KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ-AEISSLQSVRQWYQQQLALAQE 587
              + +   +Q   +    L      +   T+ L  SQ    S  + +++ Y +++    E
Sbjct: 121  CKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEV----E 176

Query: 588  ARVRLQGEMAHIQVGQMTQA---GLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQG 644
             R RL+ E+  +Q  + +Q      + H  +     S  +   Q           +Q   
Sbjct: 177  ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTP 236

Query: 645  IEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLT 704
            I  D     A++   ++  T     LQ       G+R+      D+++S           
Sbjct: 237  IRRDF---SASYFSGEQEVTPSRSTLQ------IGKRDANSSFFDNSSS----------- 276

Query: 705  LLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR 764
                   L+ L+ ++ +L  ++   +  LQ  E+ +      + ELQ +L + + E   +
Sbjct: 277  ----PHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEK 332

Query: 765  EDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQV 824
            E  +   ++E +   A    A +    L++  ++L E      +  E  R  L  K  + 
Sbjct: 333  EKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEK 392

Query: 825  E-HLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQL----ISELKATRKRLDSE 879
            E   Q+E +  ++  Q + ++ +Q K  +    + A +   +    + +L + +++L++ 
Sbjct: 393  EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENN 452

Query: 880  LKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSL 939
            L+E +Q+L +     + ++ + + L R + ++++    L+ H +   +E   +E  L+++
Sbjct: 453  LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNI 512

Query: 940  -------QFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKM-------------- 978
                   Q   E+M A   + E + + ++E   +   ++T +K K+              
Sbjct: 513  KQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD 572

Query: 979  ---------RRLGSDLTSAQKEMKT-------KHKAYENA----------VGILSRRLQE 1012
                      +L   L+  +KE K        K K YE                 + L +
Sbjct: 573  LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ 632

Query: 1013 ALAAKEAADAELGQLRAQGGSSD-SSLALHERIQALEAELQAVSHSKTLLEKELQEVIAL 1071
              + KE   +++  L     +    S   +ER++ LE + + +S    +  + L  V+  
Sbjct: 633  MESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLS----VEIRNLHNVLDS 688

Query: 1072 TSQELEESREKVLELEDELQES-RGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAA 1130
             S E+E  +   +EL+ + + S +  +K+I+ +     +L  ++E  + KL  L      
Sbjct: 689  KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNE--- 745

Query: 1131 LREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQ--ALQASLEKEKEKV 1188
            + + +   +   A+ E+ L  L     A L   E+  R +    Q  A+  S      + 
Sbjct: 746  IMDKDRCYQDLHAEYES-LRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ 804

Query: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248
             S+  + +  ++EA  + ++       +  ++  L++++ +   LQ + ++L   +G   
Sbjct: 805  GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG--- 861

Query: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWE----VDQKEREIQSLK 1304
                + +  L +A    Q    +  +++SK        +N+  E    ++ KE+E+Q L 
Sbjct: 862  ----EIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLN 917

Query: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
             +++ TEQ   +EL+    LL++   EL++  E LS+ +K+   + + +S  K  ++ L 
Sbjct: 918  DKVE-TEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKE---MSSIISLNKREIEELT 973

Query: 1365 QQNQQLK 1371
            Q+N  LK
Sbjct: 974  QENGTLK 980



 Score =  114 bits (286), Expect = 5e-25
 Identities = 190/892 (21%), Positives = 382/892 (42%), Gaps = 88/892 (9%)

Query: 622  QQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGER 681
            Q+L     +  KEK +   QL  +EA +  Q+      +   T ++ + QR +E  E   
Sbjct: 21   QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80

Query: 682  ERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLD 741
            +  Q+++      E Q+   +  L    +Q+E L+QE      +L  +Q+A QS + SL+
Sbjct: 81   KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLN 140

Query: 742  ALQTHYDELQARLGELQGEAASREDTICLLQNEKI----ILEAALQA--AKSGKEEL--- 792
               T        L   Q  + S+ + +    N+++     LEA ++A  AK   + L   
Sbjct: 141  PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA 200

Query: 793  ---DRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQK 849
                R   R +  +   S   EK    L+  S +    +  +A+     Q++       +
Sbjct: 201  TMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV----TPSR 256

Query: 850  VMVEAYRRDA-------TSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELS 902
              ++  +RDA       +S   L+ +LKA  + L +++ EL    +++ G ++  + +++
Sbjct: 257  STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE---LRLQGHEKEMKGQVN 313

Query: 903  RLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEE 962
            +      Q+ +   +L    +   K RDE+     + Q+D +     T   + LKK  E+
Sbjct: 314  KFQELQLQLEKAKVELIEKEKVLNKCRDELVR--TTAQYD-QASTKYTALEQKLKKLTED 370

Query: 963  L-----QQEARKAITEQ--KQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALA 1015
            L       E+ +   EQ  K+K +    +L+  Q+  +T  +        L++ LQ+A  
Sbjct: 371  LSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKN 430

Query: 1016 AKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQAVSHSKTLLEKELQEVIA---L 1071
                  AEL +L +     +++L    +++   E   QA    +  L + ++E+     L
Sbjct: 431  MHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490

Query: 1072 TSQELEESREKVLELEDELQ-------ESRGFRKKIKRLEESNKKLALELEHEKGK---- 1120
                 E+   +V  LE EL+       +S+ F +++K    S + +  +L+ +  +    
Sbjct: 491  LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550

Query: 1121 --LTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQ 1178
              L  L  + A L +     +  L KRE  + QLN +    L + E+E +       AL 
Sbjct: 551  LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK----LSKTEKESK-------ALL 599

Query: 1179 ASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK-EHLVQKLQAEA 1237
            ++LE +K++   LKE+          N +       ++   K+ LQ+K  HL   L+ + 
Sbjct: 600  SALELKKKEYEELKEEKTLFSCWKSENEK----LLTQMESEKENLQSKINHLETCLKTQ- 654

Query: 1238 DDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDE---QLSKQPVGNQEMENLKWEVD 1294
               QI+  ++++ +   + +      +++ L   LD    ++  Q +   E++      D
Sbjct: 655  ---QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD 711

Query: 1295 QK-EREIQSL-KQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKD-KFMLQA 1351
            QK ++EI+++  +   LT Q   ++LE   QLL N   + +   +DL    +  + +L++
Sbjct: 712  QKHQKEIENMCLKTSQLTGQV--EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769

Query: 1352 KVSELKNN---MKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPAS 1408
            K + L  N    ++LL  +QQ    +    A    E +G   S      ++    P  ++
Sbjct: 770  KDASLVTNEDHQRSLLAFDQQPA--MHHSFANIIGE-QGSMPSERSECRLEADQSPKNSA 826

Query: 1409 LLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSW 1460
            +L+  +      S E  K +NS LQ+  +E+  ++ ++EE+ +   +   S+
Sbjct: 827  ILQNRV-DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSF 877



 Score =  112 bits (279), Expect = 4e-24
 Identities = 229/1210 (18%), Positives = 489/1210 (40%), Gaps = 152/1210 (12%)

Query: 355  LGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEK 414
            L Q  ++ +VLQA   +     Q++   +   +  +C +      A++ +E  L+   E+
Sbjct: 425  LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQA-FQASQIKENELRRSMEE 483

Query: 415  MRLEGQLEALSLEASQALKEKAELQAQLAAL------STKLQAQVECSHSSQQ------- 461
            M+ E  L  L   + Q  +E   L+A+L  +      S     +++  ++SQ+       
Sbjct: 484  MKKENNL--LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQ 541

Query: 462  ---RQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAK 518
                Q   S  ++ LK +  DLE+     Q++L+ +   +   N+ L   E++ + L++ 
Sbjct: 542  EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSA 601

Query: 519  VEDMQRSMLSKDNTVHDLRQQMTAL-------QSQLQQVQLERTTLTSKLKASQAEISSL 571
            +E        K     +L+++ T         +  L Q++ E+  L SK+   +  + + 
Sbjct: 602  LE-------LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654

Query: 572  QSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRS 631
            Q     Y +++   +  R  L  E+ ++     +++  +E  KL  + L Q+   +  + 
Sbjct: 655  QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH 714

Query: 632  MKE-------KGRIAAQLQGIEA-------DMLDQEAAFMQI-------------QEAKT 664
             KE         ++  Q++ +E        +++D++  +  +             ++A  
Sbjct: 715  QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774

Query: 665  MVEEDLQRRLEEFE--------------------GERERLQRMAD----SAASLEQQLEQ 700
            +  ED QR L  F+                     ER   +  AD    ++A L+ +++ 
Sbjct: 775  VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834

Query: 701  VKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE 760
            ++ +L  + Q    LQ++  +L++     +E L   EQ     Q+   E   R+ +LQ +
Sbjct: 835  LEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMH---QSFVAETSQRISKLQED 891

Query: 761  AASRE----DTICLLQN---EKIILEAALQAAKSGKEELDRGARRLEEGTEET---SETL 810
             ++ +    +T+  L+N   E  +L   ++  ++  +EL +    LE+  +E    SETL
Sbjct: 892  TSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETL 951

Query: 811  EKLREELA----IKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLI 866
               ++E++    +   ++E L QE   LK+    + ++ +      E++      +++ I
Sbjct: 952  SLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSI 1011

Query: 867  SELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQS-A 925
            SE       L  + K+ +  L+Q   E   A  +LS+ ++   +    +  L     S  
Sbjct: 1012 SE-------LSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1064

Query: 926  QKERDEMETHLQSLQFDKEQMVA----VTEANEALKKQIEELQQEARKAITEQKQKMRRL 981
            +  ++E+E   ++   + ++ +       E N+ L  ++E +QQ  R  +T+ +   +  
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124

Query: 982  GSDLTSAQKEMKTKHKAYENAVGIL---SRRLQEALAAK-EAADAELGQLRAQGGSSDSS 1037
               L      +K +    +  V  L   + +L + +  K E  + E   +R      +S 
Sbjct: 1125 AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESE 1184

Query: 1038 LALHERIQALEAELQAVS-HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGF 1096
                     ++ E++ +S  S      +L+ ++     +L+ES ++   L+ ELQ  RG 
Sbjct: 1185 RNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGD 1244

Query: 1097 RKKIKRLEESNKKLA----LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
             +     +  +++++     E++ E+  ++G  + + + +  N+ L+ +L      L +L
Sbjct: 1245 LETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTS-QNDNAHLQCSLQTTMNKLNEL 1303

Query: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAG--HNRRHFK 1210
                + +   K E   ++         +  K  E+V  L  +V     ++G  H      
Sbjct: 1304 EKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVED 1363

Query: 1211 AASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQK 1270
                E  E   E    +H V     +  +         +E+    AEL E    LQ   K
Sbjct: 1364 IPGGEFGEQPNE----QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHK 1419

Query: 1271 QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELE-GLQQ-LLQNV 1328
             L +Q  +    + +M  L+  VD  + E   L   L   +    KE++ GL++ L+ ++
Sbjct: 1420 ILHDQHCQM---SSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSL 1476

Query: 1329 KSELEMAQEDLSMTQKDKF----MLQAKVSELKNNMKTLLQQNQ----QLKLDLRRGAAK 1380
             S        LS      F    + Q     L +N++  +  NQ    ++     +    
Sbjct: 1477 SSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENL 1536

Query: 1381 TRKEPKGEASSSNPATPIKIPD--CPV---PASLLEELLRPPPAVSKEPLKNLNSCLQQL 1435
            TRKE     + S PA  ++  +  C V       LEE +     +  + ++ L   L   
Sbjct: 1537 TRKE-----TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1591

Query: 1436 KQEMDSLQRQ 1445
            +QE+D L++Q
Sbjct: 1592 RQELDCLRKQ 1601



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 111/616 (18%), Positives = 255/616 (41%), Gaps = 78/616 (12%)

Query: 820  KSGQVEHLQQETAALKKQMQKIKEQFLQ--------------QKVMVEAYRRDATSKD-- 863
            K G      Q+   L+ Q+ K+K++  Q              QK  VE  + + T+    
Sbjct: 9    KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRE 68

Query: 864  -----QLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADL 918
                 ++   L+ T++++  EL+    ++    G+  + + ++ +L +E+ + +  +   
Sbjct: 69   NQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128

Query: 919  EGHLQSAQKERDEMET-------------HLQSLQFD--KEQMVAVTEANEALKKQIEEL 963
            +   QSA    +   T             +    +++  KE+     E  + L+ +++ L
Sbjct: 129  QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL 188

Query: 964  Q-QEARKAITEQKQKMR-----RLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAK 1017
            Q ++A + + +     R     +  S + S Q+E    H +  +    + R    +  + 
Sbjct: 189  QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSG 248

Query: 1018 E------AADAELGQLRAQGGSSDSSLALH--ERIQAL---------EAELQAVSHSKTL 1060
            E       +  ++G+  A     D+S + H  ++++A          E EL+   H K +
Sbjct: 249  EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308

Query: 1061 LE-----KELQEVIALTSQELEESREKVLELEDELQESRG----FRKKIKRLEESNKKLA 1111
                   +ELQ  +     EL E  + + +  DEL  +         K   LE+  KKL 
Sbjct: 309  KGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLT 368

Query: 1112 LELEHEKGKLTGLGQS-NAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQM 1170
             +L  ++        S    ++E     +  L++++     L+ +   +  R  +E +Q 
Sbjct: 369  EDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQA 428

Query: 1171 KHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLV 1230
            K++   LQA L+K       L+  +   K +     + F+A+ ++ +E+++ +       
Sbjct: 429  KNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSM------- 481

Query: 1231 QKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLK 1290
            ++++ E + L+    + ++E+   +AEL   +  L   Q   +E  +K       + +L+
Sbjct: 482  EEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQ 541

Query: 1291 WEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQ 1350
             +++Q+E  +   K +L + + +  K+ +  Q LL+  +  +E   + LS T+K+   L 
Sbjct: 542  EKINQQENSLTLEKLKLAVADLE--KQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALL 599

Query: 1351 AKVSELKNNMKTLLQQ 1366
            + +   K   + L ++
Sbjct: 600  SALELKKKEYEELKEE 615



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 43/187 (22%), Positives = 85/187 (45%), Gaps = 42/187 (22%)

Query: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQ--- 1305
            Q+I + + +L + + + Q  Q QLD   +      Q++EN K E    +RE Q L +   
Sbjct: 18   QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77

Query: 1306 QLDLTEQQ---------------------GRKELEGLQQLLQNVKSELEMAQE-----DL 1339
             L+ T+Q+                     G+K++E L+Q L+  KSELE +Q+     D+
Sbjct: 78   SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137

Query: 1340 SMT-----QK--------DKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPK 1386
            S+      QK         ++   +K  +LK      +++ ++L+ +++   AK   +  
Sbjct: 138  SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197

Query: 1387 GEASSSN 1393
             +A+ ++
Sbjct: 198  PQATMNH 204


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  170 bits (431), Expect = 8e-42
 Identities = 244/1088 (22%), Positives = 458/1088 (42%), Gaps = 159/1088 (14%)

Query: 512  YQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSL 571
            + +L  K++ + RS  +++     LR ++  L+  L   + +R  L     +   E + L
Sbjct: 878  WMKLFFKMKPLLRSAQAEEELAA-LRAELRGLRGALAAAEAKRQELEETHVSITQEKNDL 936

Query: 572  QSVRQWYQQQLALAQE-------ARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL 624
                Q  Q  LA A+E       ++V+L+G++  +      +  +   L      L  + 
Sbjct: 937  ALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDEC 996

Query: 625  TE----------TQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRL 674
            TE          T  ++ KEK     +++ +  +M   + +  ++ + K  ++E  Q+ L
Sbjct: 997  TELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQAL 1056

Query: 675  EEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEAL- 733
             + + E +R+  +  +   LEQQ+E ++ +L Q  +     ++    L   L LTQE++ 
Sbjct: 1057 GDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVA 1116

Query: 734  ------QSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
                  Q  E+ L    +   +L  R+ + Q   A  +  I  LQ     LE  L+A ++
Sbjct: 1117 DAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERA 1176

Query: 788  GKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQ 847
             +  ++   ++  E   E  E  E+L E     +GQ E  ++  A L +  ++++E  L+
Sbjct: 1177 ARARVE---KQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR 1233

Query: 848  QKVMVEAYRR----DATSKDQLISELKATRKRLDSELKELRQEL------------MQVH 891
             +  V A RR     A    + +  L+  R++L+ E  ELR E+             +  
Sbjct: 1234 HEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKAS 1293

Query: 892  GEK--RTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHL------------- 936
             EK  RT E +LS    +V ++++ +AD        Q E  E+   L             
Sbjct: 1294 AEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRG 1353

Query: 937  -----QSLQFDKEQMVAVTEANEALKKQIE------ELQQEARKAITEQKQKMRRLGSDL 985
                 QSL+  + Q+   ++A  AL   ++      +L +E  +   E + +++RL S  
Sbjct: 1354 KALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKA 1413

Query: 986  TSAQKEMKTKHKA--------YENAVGILSRRLQEALAAKEAADA-----ELGQLRAQGG 1032
             +   + ++K++A         E A   L+ RLQEA    EAA+A     E  +LR Q  
Sbjct: 1414 NAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTE 1473

Query: 1033 SSDSSLALHERIQALEA------ELQAVSHSKTLLEKELQEVIALTSQE----------L 1076
            S D +L L     A  A       L+     +   E+E+Q  +    +E          L
Sbjct: 1474 SEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRL 1533

Query: 1077 EESREKVLE-LEDELQESRGFRKKIKRLEES---NKKLALELEHEKGKLTG-LGQSNAAL 1131
                E+ LE LE   +E++  +++I  L +    + K   ELE  K  L G   +  AAL
Sbjct: 1534 RHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAAL 1593

Query: 1132 REHNSIL---ETALAKREADLVQLNLQVQAVLQRKEEE----DRQMKHLVQALQASLEKE 1184
             E    L   ET   + + +L Q+  +V   L  K+EE     R  +  V++LQASL+ E
Sbjct: 1594 EEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAE 1653

Query: 1185 ----------KEK----VNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLV 1230
                      K+K    +N L+ Q+  A  +A   +   +    +L E +     ++ L 
Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLA 1713

Query: 1231 QKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQ------LSKQPVG-- 1282
             +L  +A  L+ R    + E+ + +A L +     +L +++L E       L  Q  G  
Sbjct: 1714 AELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLL 1773

Query: 1283 NQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSE------LEMAQ 1336
            NQ+ + L+ ++ Q   E++   Q+    E++ +K +     + + +K E      LE  +
Sbjct: 1774 NQK-KKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1832

Query: 1337 EDLSMTQKDKFMLQAKVSELKN-NMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPA 1395
            + L  T ++   LQA++ E +   ++   +Q Q+L+  +R   A+   E K  A +    
Sbjct: 1833 KTLEQTVRE---LQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGV 1889

Query: 1396 TPIKIPDCPVPASLLEELLRPPPAVSKEPLKNL---NSCLQQLKQEMDSLQRQMEEHALT 1452
                           E  ++     ++E  KNL      + +L+ ++ S +RQ EE    
Sbjct: 1890 RK------------HERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQ 1937

Query: 1453 VHESLSSW 1460
             + +L+ +
Sbjct: 1938 ANTNLAKY 1945



 Score =  162 bits (411), Expect = 2e-39
 Identities = 231/1087 (21%), Positives = 467/1087 (42%), Gaps = 111/1087 (10%)

Query: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ 420
            ++  L AA A+ Q+  +      + + D      + + + A+ +E    ++K K++LEG+
Sbjct: 908  LRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGK 967

Query: 421  LEALSLEASQALKEKAELQAQLAALSTKLQAQVECSH-------------SSQQRQDSLS 467
            ++    E S+ L+++ E+ A LAA   KL+   EC+               +++ + +  
Sbjct: 968  VK----ELSERLEDEEEVNADLAARRRKLED--ECTELKKDIDDLKLTLAKAEKEKQATE 1021

Query: 468  SEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQ-------RLMAKVE 520
            ++V  L +    L+ ++  L    +A   +   +  DLQ  E++         RL  +VE
Sbjct: 1022 NKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVE 1081

Query: 521  DMQRSMLSKDNTVHDLRQQMTALQSQLQQVQ-------LERTTLTSKLKASQAEISSLQS 573
            D++ S+  +     D  +    L+  L+  Q        ++  L  KLK   +E+S L S
Sbjct: 1082 DLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQL-S 1140

Query: 574  VRQWYQQQLALAQEARVR-LQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSM 632
            +R   +Q L    + +++ LQ     ++     +      ++ +    +++L E   R  
Sbjct: 1141 LRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLE 1200

Query: 633  KEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERL-----QRM 687
            +  G  A Q +G       +EA   +           L+R LEE     E       ++ 
Sbjct: 1201 EAGGASAGQREGCR----KREAELGR-----------LRRELEEAALRHEATVAALRRKQ 1245

Query: 688  ADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHY 747
            A+ AA L +Q++ ++    + +++   L+ E  DL   +     A  S E+     +   
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305

Query: 748  DELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETS 807
             E + ++ ELQ + A        LQ E   L   L+  +    +L RG     +  EE  
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365

Query: 808  ETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKE-QFLQQKVMVEAYRRDATSKDQLI 866
              LE+  +  +  +  V+ L+ +   L++Q ++  E Q   Q+++ +A    A  + +  
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425

Query: 867  SELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQ--- 923
            ++     + L+   K+L   L +       A A+ S L +   +++    D+   L+   
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485

Query: 924  SAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGS 983
            SA    D+ + HL+    ++ +        E +++++E  Q+E+R   TE   ++R    
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQ------EEEMQRELEAAQRESRGLGTE-LFRLRHGHE 1538

Query: 984  DLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHER 1043
            +   A + +K ++K  +  +  L+   Q +L+ K   + E  +   +G  S+   AL E 
Sbjct: 1539 EALEALETLKRENKNLQEEISDLTD--QVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596

Query: 1044 IQALEAELQAVSHSKTL-LEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKR 1102
              ALE E      +KTL ++ EL +V A   ++L E  E+   L    Q +    +    
Sbjct: 1597 EGALELE-----ETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLD 1651

Query: 1103 LEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR 1162
             E   +  AL L   K K+ G   ++  L+  ++  +   A+    L+Q  L+ +     
Sbjct: 1652 AETRARNEALRL---KKKMEG-DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQA--G 1705

Query: 1163 KEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKE 1222
            ++EE R    L +  QA LE+    + +  E++ AA  +   +RR  +   LE +E    
Sbjct: 1706 RDEEQRLAAELHEQAQA-LERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNL 1764

Query: 1223 LQAKEH--LVQKLQAEADDLQ----IREGKHSQEIAQFQAELA---------------EA 1261
            L ++    L QK + EAD  Q    + E    +  A+ +A+ A               + 
Sbjct: 1765 LHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDT 1824

Query: 1262 RAQLQLLQKQLDEQLSKQPVGNQEMENL-----KWEVDQKEREIQSLKQQLDLTEQQGRK 1316
             A L+ ++K L++ + +     +E E       K +V + E +++ L+ +LD  +++  +
Sbjct: 1825 SAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1884

Query: 1317 ELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRR 1376
             L+G+++  + VK     A+ED    +K+   +Q  V +L++ +K+  +Q ++ +     
Sbjct: 1885 ALKGVRKHERRVKELAYQAEED----RKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANT 1940

Query: 1377 GAAKTRK 1383
              AK RK
Sbjct: 1941 NLAKYRK 1947


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  170 bits (430), Expect = 1e-41
 Identities = 245/1104 (22%), Positives = 479/1104 (43%), Gaps = 142/1104 (12%)

Query: 392  SSVSLESSAAETQEEMLQVLKEKMRL-EGQLEALSLEASQALKEKAELQAQLAALSTKLQ 450
            S+++L  SA   ++  +Q ++ +    +  L  L  + S +  E+  L+ QL  L  K  
Sbjct: 519  STLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTD 578

Query: 451  AQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEE 510
              ++    +Q+    L S  + L +   +L  ++   Q   E     L      LQ A+E
Sbjct: 579  GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAE----ELRQEREKLQAAQE 634

Query: 511  QYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS 570
            + +R   ++E+ Q   +     V   R+++     QL+Q++ +R+ L  +L   +  +S 
Sbjct: 635  ELRRQRDRLEEEQEDAVQDGARV---RRELERSHRQLEQLEGKRSVLAKELVEVREALSR 691

Query: 571  LQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHR 630
                R   Q + A   EA  + +     +++  MT+    E    +++S    L E+  +
Sbjct: 692  ATLQRDMLQAEKAEVAEALTKAEAGRVELELS-MTKLRAEEASLQDSLSKLSALNESLAQ 750

Query: 631  SMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADS 690
               +  R+ AQL+  ++ +  ++    Q ++  T+  E+ Q RLEE   E+E  ++  + 
Sbjct: 751  DKLDLNRLVAQLEEEKSALQGRQR---QAEQEATVAREE-QERLEELRLEQEVARQGLEG 806

Query: 691  AASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDEL 750
            +  + +Q ++        +QQL  L+ E   L +QL      L  REQ L+  +    E 
Sbjct: 807  SLRVAEQAQEAL------EQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR---EA 857

Query: 751  QARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETL 810
            Q ++  L+  A  +E     L  E   L   L AA+     L   A RL    E    +L
Sbjct: 858  QRQVEALERAAREKE----ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSL 913

Query: 811  EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELK 870
             +++ +LA    + E L+ E  AL    + +  +    +  + A +  A+          
Sbjct: 914  FEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS---------- 963

Query: 871  ATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERD 930
                 LD EL  + Q+L+Q   E + +  E    H E  Q       L+   ++A +E +
Sbjct: 964  -----LDKEL--MAQKLVQAEREAQASLREQRAAHEEDLQ------RLQREKEAAWRELE 1010

Query: 931  EMETHLQS-LQFDKEQMVAVTEAN-EALKKQIEELQQEARKAI----TEQKQKMRRLGSD 984
                 LQS LQ ++E+++A  EA  E L ++I  LQQE  + +    +E++Q +    S+
Sbjct: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070

Query: 985  LTS-AQKEMKTKHKAYENAVGILSRRLQEALAAKE-------AADAELGQLRAQGGSSDS 1036
             T+ ++K M T+H     ++  + R+ ++A + +E       A  +EL  LRAQ    ++
Sbjct: 1071 KTALSEKLMGTRHSLATISLE-MERQKRDAQSRQEQDRSTVNALTSELRDLRAQ--REEA 1127

Query: 1037 SLALHERIQALEAELQAVSHSKTLLEKELQEV---IALTSQELEESREKVLELEDELQES 1093
            + A  + ++ L+ + + +   +    +E +E+   + L     +  R ++LE + +L+ES
Sbjct: 1128 AAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRES 1187

Query: 1094 RGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLN 1153
            +  R       E  ++ A EL    G+     +   ALR  N  L +A+ K E++ + L 
Sbjct: 1188 QEGR-------EVQRQEAGELRRSLGEGA---KEREALRRSNEELRSAVKKAESERISLK 1237

Query: 1154 LQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAAS 1213
            L          E+  Q   L++  + ++ KE  ++ +  ++V  +++EA   RR      
Sbjct: 1238 LA--------NEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEA---RR------ 1280

Query: 1214 LELSEVKKELQAKEHLVQKLQAEADDLQIR-------EGKHSQEIAQFQAELAEARAQLQ 1266
             EL E++++++  +    +L  E  +LQ R       E +  +E    +  L +  A L+
Sbjct: 1281 -ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLE 1339

Query: 1267 LLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQ 1326
            +++++L        V  ++++  + E   +ER +    ++   TE+Q      GL+  L+
Sbjct: 1340 VMRQELQ-------VAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLE 1392

Query: 1327 NVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRG--------- 1377
              ++E       LS  +     L+A+++ ++   +    Q   L+  LRRG         
Sbjct: 1393 AARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSP 1452

Query: 1378 ---------AAKTRKEPKGEASSSNPAT----PIKIPDCPVPASLLEELLRPPPAVSKEP 1424
                     A     E  GE  +S P+T    P   P  P PA+        P +   +P
Sbjct: 1453 APRPVPGSPARDAPAEGSGEGLNS-PSTLECSPGSQPPSPGPAT-------SPASPDLDP 1504

Query: 1425 LKNLNSCLQQLKQEMDSLQRQMEE 1448
             + +   L++  QE+ S QR+ +E
Sbjct: 1505 -EAVRGALREFLQELRSAQRERDE 1527



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1137 (22%), Positives = 482/1137 (42%), Gaps = 164/1137 (14%)

Query: 357  QFPSIKDVLQAAAAEHQDQGQEVN-----GEVRSRRDS-ICSSVSLESSAAET---QEEM 407
            Q   ++D    A   H+D  +EV       E+ SR  S +  S+ +    AE    + E 
Sbjct: 569  QLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREK 628

Query: 408  LQVLKEKMRLEGQLEALSLEASQALKEKAELQAQL--------------AALSTKLQAQV 453
            LQ  +E++R   Q + L  E   A+++ A ++ +L              + L+ +L    
Sbjct: 629  LQAAQEELRR--QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686

Query: 454  ECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQ---NMLEAKNASLASSNNDLQVAEE 510
            E    +  ++D L +E   + ++    E    +L+     L A+ ASL  S + L    E
Sbjct: 687  EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 746

Query: 511  QY-------QRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKA 563
                      RL+A++E+ + ++  +              Q +L++++LE+      L+ 
Sbjct: 747  SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 806

Query: 564  SQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQ 623
            S   +   +  ++  +QQL   +  R +LQ ++A +      +   LE  + E    +Q+
Sbjct: 807  S---LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE----AQR 859

Query: 624  LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEE--FEGER 681
              E   R+ +EK  +A +  G+   ++  E      +E +T+ EE  + RLE+   EG  
Sbjct: 860  QVEALERAAREKEALAKEHAGLAVQLVAAE------REGRTLSEEATRLRLEKEALEGSL 913

Query: 682  ERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQE-ALQSREQSL 740
              +QR      +  +QLE     LL      E L  E   L +Q+  TQE A   +E   
Sbjct: 914  FEVQRQLAQLEARREQLEAEGQALLLAK---ETLTGELAGLRQQIIATQEKASLDKELMA 970

Query: 741  DALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSG-----KEELDRG 795
              L     E QA L E   + A+ E+ +  LQ EK      L+A ++      + E +  
Sbjct: 971  QKLVQAEREAQASLRE---QRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL 1027

Query: 796  ARRLEEGTEETSETLEKLREE-----LAIKSGQVEHL---QQETAALKKQMQKIKEQFLQ 847
              RLE   EE SE +  L++E     L  +S + + L   + E  AL +++   +     
Sbjct: 1028 LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT 1087

Query: 848  QKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHRE 907
              + +E  +RDA S+ +   + ++T   L SEL++LR +      E   A A+      E
Sbjct: 1088 ISLEMERQKRDAQSRQE---QDRSTVNALTSELRDLRAQ----REEAAAAHAQ------E 1134

Query: 908  VAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA-VTEANEALKKQIE--ELQ 964
            V ++++   DL     S  +E +E+ T L+ L+  ++ +   + EA   L++  E  E+Q
Sbjct: 1135 VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194

Query: 965  Q----EARKAITE---QKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAK 1017
            +    E R+++ E   +++ +RR   +L SA K+ +++  + + A     ++L     A+
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254

Query: 1018 EAADAELGQLRAQGGSSDSS-LALHERIQALEAELQAVSHSKTLLEKELQEV---IALTS 1073
             A   E G+LR      + S L     +Q L  +++ +    T L +EL E+   +AL  
Sbjct: 1255 TAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGE 1314

Query: 1074 QELEESREKVLELED---------------------ELQESRG-FRKKIKRL----EESN 1107
            +  +ESR + L L                       +LQE  G FR + +RL    EE+ 
Sbjct: 1315 RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374

Query: 1108 KKLALELEHEKG---KLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKE 1164
                 +L+H +G   KL       A L    S  E      EA+L ++ +Q +A      
Sbjct: 1375 GTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAA----- 1429

Query: 1165 EEDRQMKHLVQALQASL-----------------------EKEKEKVNSLKEQVAAAKVE 1201
              + Q+  L  AL+  L                       E   E +NS      +   +
Sbjct: 1430 --EAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQ 1487

Query: 1202 AGHNRRHFKAASLELSEVKKELQAKEHL--VQKLQAEADDLQIREGKHSQEIAQFQAELA 1259
                      AS +L         +E L  ++  Q E D+L+ +    ++++A+ +AE  
Sbjct: 1488 PPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERD 1547

Query: 1260 EARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELE 1319
             A ++ + LQK + E    +   +  +  ++ E+  +E  ++  +++   T  Q    + 
Sbjct: 1548 SATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQ----VA 1603

Query: 1320 GLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRR 1376
             L++ LQ  +SEL  +QE +S  + ++  L+     LK  +     +++ +KL+L+R
Sbjct: 1604 TLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA--SESRTVKLELQR 1658



 Score =  163 bits (413), Expect = 1e-39
 Identities = 303/1437 (21%), Positives = 592/1437 (41%), Gaps = 203/1437 (14%)

Query: 99   GFHDNLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTD--SPLPLEKEEQVRLQARK 156
            G  D  + +Q TS    +R+  + +  LS P     L +T+  S L L++E Q+  Q   
Sbjct: 34   GARDLAQDAQITSLPALIRE--IVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELS 91

Query: 157  WLEEQLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTS 216
             +E+ L Q R +R +      A   RL    +  L L P  L                T 
Sbjct: 92   RVEDLLAQSRAERDELAIKYNAVSERL----EQALRLEPGEL---------------ETQ 132

Query: 217  VPRGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQN 276
             PRG    S+ L    +E++ S   K+++  + +   +               +G + Q 
Sbjct: 133  EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQL---------VQRLQGKILQY 183

Query: 277  RSSAASVVSEI-SLSPDTDD-RLENTSLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSK 334
            +   + +  ++   S + +  RL +T  + D  S +   + +     SAS      +L +
Sbjct: 184  KKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQR--SASLAQVNAMLRE 241

Query: 335  TVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSIC--- 391
             +    +      ++I   T       K++    AA  +++ +  N    +    +    
Sbjct: 242  QLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE-ESFNAYFSNEHSRLLLLW 300

Query: 392  -SSVSLESSAAE----TQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALS 446
               V      +E    T+ ++LQ+  E  R    ++   L  S  L+  AE +A+ AAL 
Sbjct: 301  RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLR-LAESRAE-AALE 358

Query: 447  TK--LQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNND 504
             +  LQAQ+E     +Q +D +  E D  +Q            Q   +   A L++   +
Sbjct: 359  KQALLQAQLE-----EQLRDKVLREKDLAQQ------------QMQSDLDKADLSARVTE 401

Query: 505  LQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKAS 564
            L +A          V+ +++  L KD    DL +++ AL+S   Q Q       + L+  
Sbjct: 402  LGLA----------VKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQ-------AALETE 444

Query: 565  QAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL 624
              E   LQ   +   Q +    E+ V+L G          +  GL            Q+ 
Sbjct: 445  DGE--GLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLS----------GQRT 492

Query: 625  TETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERL 684
                 RS   +GR  +  +G      D             ++   L +R  + +  R R 
Sbjct: 493  PSPPRRSSPGRGR--SPRRGPSPACSDSSTL--------ALIHSALHKRQLQVQDMRGRY 542

Query: 685  QRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQ 744
            +   D   +L +QL   +      ++QL+ L+ +          T  A+Q+ E +    Q
Sbjct: 543  EASQDLLGTLRKQLSDSESERRALEEQLQRLRDK----------TDGAMQAHEDA----Q 588

Query: 745  THYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTE 804
                 L++    L  E ++   ++ + Q +   L    +  ++ +EEL R   RLEE  E
Sbjct: 589  REVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQE 648

Query: 805  ETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQ 864
            +  +   ++R EL     Q+E L+ + + L K++ +++E   +  +  +  + +     +
Sbjct: 649  DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708

Query: 865  LISELKATRKRLDSELKELRQE-------LMQVHGEKRTAEAELSRLHREVAQVRQHMAD 917
             +++ +A R  L+  + +LR E       L ++     +   +   L+R VAQ+ +  + 
Sbjct: 709  ALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSA 768

Query: 918  LEGHLQSAQKE----RDEMETHLQSLQFDKE--------QMVAVTEANEALKKQIEELQQ 965
            L+G  + A++E    R+E E  L+ L+ ++E         +    +A EAL++Q+  L+ 
Sbjct: 769  LQGRQRQAEQEATVAREEQE-RLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827

Query: 966  EARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG 1025
            E     ++ ++++ +L   L+  ++E++   +  +  V  L R  +E    KEA   E  
Sbjct: 828  ER----SQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAARE----KEALAKEHA 879

Query: 1026 QLRAQGGSSD-SSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL 1084
             L  Q  +++     L E    L  E +A+  S   ++++L ++ A   Q   E +  +L
Sbjct: 880  GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLL 939

Query: 1085 ELEDELQESRGFRKKIKRLEES---NKKLALE--LEHEKGKLTGLGQSNAALREHNSIL- 1138
              E    E  G R++I   +E    +K+L  +  ++ E+     L +  AA  E    L 
Sbjct: 940  AKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ 999

Query: 1139 ---ETALAKREADLVQLNLQVQ----AVLQRKEEEDRQMKHLVQALQAS-------LEKE 1184
               E A  + EA+  QL  Q+Q     +L R E E  ++   + ALQ          E E
Sbjct: 1000 REKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESE 1059

Query: 1185 KEKVNSLKEQVAAAKVEAGHNRRHFKAA-SLELSEVKKELQAKEH----LVQKLQAEADD 1239
            K++  SLKE    A  E     RH  A  SLE+   K++ Q+++      V  L +E  D
Sbjct: 1060 KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRD 1119

Query: 1240 LQIRE----GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQ 1295
            L+ +       H+QE+ + Q +  +   Q     ++ +E  ++  +     + L+ E+ +
Sbjct: 1120 LRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179

Query: 1296 KEREIQSLKQQLDLTEQ----------QGRKELEGLQQLLQNVKSELEMAQED---LSMT 1342
             +R+++  ++  ++  Q          +G KE E L++  + ++S ++ A+ +   L + 
Sbjct: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239

Query: 1343 QKDKFMLQAKVSELK-------NNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPA 1395
             +DK    A + E +         ++T LQ+ ++ +L+ RR   + R++ K    S N  
Sbjct: 1240 NEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK-MLDSENTR 1298

Query: 1396 TPIKIPDCPVPASLLE----ELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448
               ++ +     +L E    E  R    + +  LK   + L+ ++QE+   QR+++E
Sbjct: 1299 LGRELAELQGRLALGERAEKESRRETLGLRQRLLKG-EASLEVMRQELQVAQRKLQE 1354



 Score =  155 bits (392), Expect = 3e-37
 Identities = 259/1181 (21%), Positives = 487/1181 (41%), Gaps = 213/1181 (18%)

Query: 369  AAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLK-EKMRLEGQLEALSLE 427
            A E Q++ +E+  E    R  +  S+ +   A E  E+ L  L+ E+ +L+ QL  LS +
Sbjct: 783  AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842

Query: 428  AS---------------------QALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSL 466
             S                     +A +EK  L  + A L+ +L A      +  +    L
Sbjct: 843  LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902

Query: 467  SSEVDTLKQSCWDLERAMTDLQ---NMLEAKNASLASSNNDL---------QVAEEQYQR 514
              E + L+ S ++++R +  L+     LEA+  +L  +   L         Q+   Q + 
Sbjct: 903  RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA 962

Query: 515  LMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSV 574
             + K    Q+ + ++      LR+Q  A +  LQ++Q E+     +L+A +A+   LQS 
Sbjct: 963  SLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQ---LQSQ 1019

Query: 575  RQWYQQQLALAQEA-RVRLQGEMAHIQVGQMTQAGLL-------EHLKL---ENVSLSQQ 623
             Q  Q++L    EA +  L  E+A +Q  Q    GLL       + L L   E  +LS++
Sbjct: 1020 LQREQEELLARLEAEKEELSEEIAALQ--QERDEGLLLAESEKQQALSLKESEKTALSEK 1077

Query: 624  LTETQH----------------RSMKEKGR-----IAAQLQGIEADMLDQEAAFMQIQEA 662
            L  T+H                +S +E+ R     + ++L+ + A    +EAA    QE 
Sbjct: 1078 LMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQR--EEAAAAHAQEV 1135

Query: 663  KTMVEE--DLQRR----LEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            + + E+  DL ++    L E E  R +L+ + D+   L ++L + +  L +  +  E  +
Sbjct: 1136 RRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQR 1195

Query: 717  QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
            QE  +L + L    E  + RE    AL+   +EL++ + + + E  S +      + +  
Sbjct: 1196 QEAGELRRSLG---EGAKERE----ALRRSNEELRSAVKKAESERISLKLANEDKEQKLA 1248

Query: 777  ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAAL-- 834
            +LE A  A      EL  G + +E    E    L++LR ++ +   +   L +E A L  
Sbjct: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQG 1308

Query: 835  ------------KKQMQKIKEQFLQQKVMVEAYRRD------------------------ 858
                        +++   ++++ L+ +  +E  R++                        
Sbjct: 1309 RLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLG 1368

Query: 859  ------ATSKDQL----------------ISELKATRKRLDSELKELRQELMQVHGEKRT 896
                   T K QL                 +EL       +   + L  EL +V  ++R 
Sbjct: 1369 SLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRA 1428

Query: 897  AEAELSRLH-----------------REVAQVRQHMADLEGHLQSAQKERD-EMETHLQS 938
            AEA+L  L                  R V       A  EG  +        E     Q 
Sbjct: 1429 AEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQP 1488

Query: 939  LQFDKEQMVAVTEAN-EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHK 997
                     A  + + EA++  + E  QE R A  E + ++R   S L     EM+ +  
Sbjct: 1489 PSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE-RDELRTQTSALNRQLAEMEAERD 1547

Query: 998  AYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHER-IQALEAELQAVSH 1056
            +  +    L + + E+  A+ + D  L  ++A+       LAL E  ++  E E +A   
Sbjct: 1548 SATSRARQLQKAVAESEEARRSVDGRLSGVQAE-------LALQEESVRRSERERRATLD 1600

Query: 1057 SKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEH 1116
                LE+ LQ     T  EL  S+EK+ +++    +  G ++++K + ++++   ++LE 
Sbjct: 1601 QVATLERSLQA----TESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLEL 1656

Query: 1117 EKGKLTG------LGQSNA-----ALREHNSILETALAKREADLVQLNLQVQAV---LQR 1162
            ++  L G      LG S+      AL++    L+  +A  E     L L V+ +   L +
Sbjct: 1657 QRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAK 1716

Query: 1163 KEEEDRQMKHLVQALQASLEKEKEKVNSLKEQ---VAAAKVEAGHNRR----HFKAASLE 1215
             EE +  ++  V+ L  +L +    +NS +++   +  A     H+R+       AA   
Sbjct: 1717 VEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQA 1776

Query: 1216 LSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEAR----AQLQLLQKQ 1271
            LSE +K+  +    VQ L+ E  DL+++  +   ++ Q +  L + +    A L  +QK 
Sbjct: 1777 LSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKL 1836

Query: 1272 LDEQ-LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKS 1330
             DE+ L ++ +G+ +    + E +++E E  +L+ +         K+   L++ L  V+ 
Sbjct: 1837 QDERRLLQERLGSLQRALAQLEAEKREVERSALRLE---------KDRVALRRTLDKVER 1887

Query: 1331 ELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLK 1371
            E   + ED      +K  L   ++  +  +    +Q QQL+
Sbjct: 1888 EKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLE 1928



 Score =  153 bits (386), Expect = 1e-36
 Identities = 238/1055 (22%), Positives = 451/1055 (42%), Gaps = 151/1055 (14%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEAL 424
            L+A  A+ Q Q Q    E+ +R ++    +S E +A + + +   +L E  + +    AL
Sbjct: 1009 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQ----AL 1064

Query: 425  SLEASQ--ALKEKAE-LQAQLAALSTKLQAQVECSHSSQQRQDS----LSSEVDTLK--- 474
            SL+ S+  AL EK    +  LA +S +++ Q   + S Q++  S    L+SE+  L+   
Sbjct: 1065 SLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQR 1124

Query: 475  --------QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSM 526
                    Q    L+    DL    ++           L++ E+    L  ++ + QR +
Sbjct: 1125 EEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKL 1184

Query: 527  LSKDNTVHDLRQQMTALQSQLQQVQLERTTLT-------SKLKASQAEISSLQSVRQWYQ 579
                      RQ+   L+  L +   ER  L        S +K +++E  SL+   +  +
Sbjct: 1185 RESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKE 1244

Query: 580  QQLALAQEARVRLQGEMAHIQVG-QMTQAGLLEH-------------LKLENVSLSQQLT 625
            Q+LAL +EAR  +  E   ++ G Q  +   LE              L  EN  L ++L 
Sbjct: 1245 QKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304

Query: 626  ETQ------HRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
            E Q       R+ KE  R   +  G+   +L  EA+   +++   + +  LQ +  EF  
Sbjct: 1305 ELQGRLALGERAEKESRR---ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRT 1361

Query: 680  ERERLQRMADSAASLE-QQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQ 738
               RL    + A   E QQL+  +   L+    LEA + E  +L  +L+  +   Q  E 
Sbjct: 1362 RERRLLGSLEEARGTEKQQLDHARGLELK----LEAARAEAAELGLRLSAAEGRAQGLEA 1417

Query: 739  SLDALQTHYDELQARLGELQ---------GEAAS----------REDTICLLQNEKIILE 779
             L  ++      +A+LG L+         G A S            D       E +   
Sbjct: 1418 ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP 1477

Query: 780  AALQAAKSGKEELDRGARRLEE---GTEETSETLEKLREELAIKSGQVEHLQQETAALKK 836
            + L+ +   +      A          E     L +  +EL     + + L+ +T+AL +
Sbjct: 1478 STLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR 1537

Query: 837  QMQKIKEQFLQQKVMVEAYRRDATSK----DQLISELKATRKRLDSELKELRQELMQVHG 892
            Q+ ++           EA R  ATS+     + ++E +  R+ +D  L  ++ EL     
Sbjct: 1538 QLAEM-----------EAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE 1586

Query: 893  EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEA 952
              R +E E      +VA + + +   E  L+++Q++  +M+ +   L+ DK ++  V +A
Sbjct: 1587 SVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA 1646

Query: 953  NEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQE 1012
            +E+   ++E LQ+ +     E + +  RLG     AQ +      A ++ V  L R++  
Sbjct: 1647 SESRTVKLE-LQRRS----LEGELQRSRLGLSDREAQAQ------ALQDRVDSLQRQV-- 1693

Query: 1013 ALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKE---LQEVI 1069
                   AD+E+            +  L   ++ L   L  V  S+  L  +   L E +
Sbjct: 1694 -------ADSEV-----------KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735

Query: 1070 ALTSQELEESREKVLELEDELQESRGFRKKIK-RLEESNKKLALELEHEKGKLTGLGQSN 1128
            A +S  L  +R+K L L+  L      R+ ++ RL+ + + L+      + + + LG+  
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS----EARKQSSSLGEQV 1791

Query: 1129 AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
              LR   + LE    + E  L QL    + VL++++E +    + VQ LQ      +E++
Sbjct: 1792 QTLRGEVADLELQRVEAEGQLQQL----REVLRQRQEGEAAALNTVQKLQDERRLLQERL 1847

Query: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQ--KLQAEADDLQI--RE 1244
             SL+  +A  + E    +R  + ++L L + +  L+     V+  KL++  D +++   +
Sbjct: 1848 GSLQRALAQLEAE----KREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEK 1903

Query: 1245 GKHSQEIAQFQAELAEARAQLQLLQKQ---LDEQLSKQPV---GNQEMENLKWEVDQKER 1298
            G+  + +   + ELAEA+ Q+Q L+ Q   L++  S   +     Q+   L+ EV++   
Sbjct: 1904 GRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRS 1963

Query: 1299 EIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELE 1333
                 ++ L+  E+  R+ + GL++ +  +K +L+
Sbjct: 1964 AQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ 1998



 Score =  109 bits (273), Expect = 2e-23
 Identities = 196/945 (20%), Positives = 381/945 (40%), Gaps = 121/945 (12%)

Query: 365  LQAAAAEHQDQGQEVNGEVRSRRDSICSSVS-LESSAAETQEEMLQVLKEKMRLEGQLEA 423
            L   + E + Q ++        R ++ +  S L    A+ +E      +E  RL+ Q   
Sbjct: 1085 LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARD 1144

Query: 424  LSLEASQALKEKAELQAQLAALSTK--------LQAQVECSHSSQQRQDSLSSEVDTLKQ 475
            L  +    L+E  EL+ QL  L           L+AQ +    SQ+ ++    E   L++
Sbjct: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKL-RESQEGREVQRQEAGELRR 1203

Query: 476  SCWD-------LERAMTDLQNML---EAKNASLASSNND----LQVAEE-------QYQR 514
            S  +       L R+  +L++ +   E++  SL  +N D    L + EE       +   
Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263

Query: 515  LMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKL-------KASQAE 567
            L   +++++RS L     + +LR+QM  L S+  ++  E   L  +L       K S+ E
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323

Query: 568  ISSL-------QSVRQWYQQQLALAQEARVRLQGEMAHIQ---VGQMTQAGLLEHLKLEN 617
               L       ++  +  +Q+L +AQ      +GE    +   +G + +A   E  +L++
Sbjct: 1324 TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383

Query: 618  VSLSQQLTETQHRSMKEKG-RIAA---QLQGIEADM----LDQEAAFMQIQEAKTMVEED 669
                +   E       E G R++A   + QG+EA++    + + AA  Q+   ++ +   
Sbjct: 1384 ARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443

Query: 670  L----------------QRRLEEFEGERERLQRM----------------ADSAASLEQQ 697
            L                  R    EG  E L                   A S AS +  
Sbjct: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503

Query: 698  LEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGEL 757
             E V+  L +  Q+L + Q+E  +L  Q +     L   E   D+  +   +LQ  + E 
Sbjct: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563

Query: 758  QGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREEL 817
            +    S +  +  +Q E  + E +++ ++  +         LE   + T   L   +E++
Sbjct: 1564 EEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKI 1623

Query: 818  AIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQL----ISELKATR 873
            +        L+ +    K++++++ +    + V +E  RR    + Q     +S+ +A  
Sbjct: 1624 SKMKANETKLEGD----KRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQA 1679

Query: 874  KRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEME 933
            + L   +  L++++     +  T +  + RL+  +A+V +    L   ++   +   +  
Sbjct: 1680 QALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSS 1739

Query: 934  THLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMK 993
              L S +     +     A E  ++ ++E    AR+A++E +++   LG  + + + E+ 
Sbjct: 1740 ASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVA 1799

Query: 994  TKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQA------- 1046
                    A G L ++L+E L  ++  + E   L       D    L ER+ +       
Sbjct: 1800 DLELQRVEAEGQL-QQLREVL--RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQ 1856

Query: 1047 LEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEES 1106
            LEAE + V  S   LEK+    +AL     +  REK+   ED ++ S     +  RL+ +
Sbjct: 1857 LEAEKREVERSALRLEKDR---VALRRTLDKVEREKLRSHEDTVRLS----AEKGRLDRT 1909

Query: 1107 NKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEE 1166
                 LEL   + ++  L      L + +S      A+ E D  Q  L++Q  ++R    
Sbjct: 1910 LTGAELELAEAQRQIQQLEAQVVVLEQSHS-----PAQLEVDAQQQQLELQQEVERLRSA 1964

Query: 1167 DRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKA 1211
              Q +   + L+A     +++V  L+EQV+  K +     R   A
Sbjct: 1965 QAQTE---RTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 110/476 (23%), Positives = 203/476 (42%), Gaps = 61/476 (12%)

Query: 360  SIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKM---- 415
            S+   L    AE   Q + V    R RR ++    +LE S   T+ E L+  +EK+    
Sbjct: 1569 SVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESE-LRASQEKISKMK 1627

Query: 416  ----RLEGQLEALS--LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSE 469
                +LEG    L   L+AS++   K ELQ +  +L  +LQ         + +  +L   
Sbjct: 1628 ANETKLEGDKRRLKEVLDASESRTVKLELQRR--SLEGELQRSRLGLSDREAQAQALQDR 1685

Query: 470  VDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSK 529
            VD+L++   D E     LQ  +E  N +LA         EE    L  KV  +  ++   
Sbjct: 1686 VDSLQRQVADSEVKAGTLQLTVERLNGALAK-------VEESEGALRDKVRGLTEALAQS 1738

Query: 530  DNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEAR 589
              +++  R +   LQ  L   + +R  L  +L A++  +S  +      +Q  +L ++ +
Sbjct: 1739 SASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEAR------KQSSSLGEQVQ 1792

Query: 590  VRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADM 649
              L+GE+A +++ ++   G L+ L+                       +  Q Q  EA  
Sbjct: 1793 T-LRGEVADLELQRVEAEGQLQQLR----------------------EVLRQRQEGEAAA 1829

Query: 650  LDQEAAFMQIQEAKTMVEE---DLQRRLEEFEGERERLQRMA----DSAASLEQQLEQVK 702
            L+      ++Q+ + +++E    LQR L + E E+  ++R A        +L + L++V+
Sbjct: 1830 LN---TVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE 1886

Query: 703  LTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAA 762
               L+  +    L  E   L + LT  +  L   ++ +  L+     L+      Q E  
Sbjct: 1887 REKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVD 1946

Query: 763  SREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLE-KLREEL 817
            +++  + L Q  + +  A  Q  ++  E  +R  R+   G EE   TL+ +L++EL
Sbjct: 1947 AQQQQLELQQEVERLRSAQAQTERT-LEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 115/545 (21%), Positives = 209/545 (38%), Gaps = 76/545 (13%)

Query: 67   CQNGPTPPFPDPPSSLDPTTSPVGPDASP-----GVAGFHDNLRKSQGTSAEGSVRKEAL 121
            C  G  PP P P       TSP  PD  P      +  F   LR +Q    E   +  AL
Sbjct: 1482 CSPGSQPPSPGP------ATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSAL 1535

Query: 122  QSLRLSLPMQETQLCSTDSPLP---LEKEEQVR--------LQARKWLEEQLKQYRVKRQ 170
                  +  +     S    L     E EE  R        +QA   L+E+  +   + +
Sbjct: 1536 NRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERER 1595

Query: 171  QERSSQPATKTRLFSTLDPELMLNPENLPRA-------------------STLAMTKEYS 211
            +    Q AT  R     + EL  + E + +                    ++ + T +  
Sbjct: 1596 RATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655

Query: 212  FLRTSVPRGPKVGSLGL---PAHPREKKTSKSSKIRSLADYR----TEDSNAGNSGGNVP 264
              R S+    +   LGL    A  +  +    S  R +AD      T         G + 
Sbjct: 1656 LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALA 1715

Query: 265  APDSTKGSLKQNRSSAASVVSEISLS----PDTDDRLENTSLAGDSVSEVDGNDSDSSSY 320
              + ++G+L+         +++ S S     D +  L+    A +   +V     D++  
Sbjct: 1716 KVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQ 1775

Query: 321  SSASTRGTYGILSKTVGT-QDTPYMVNGQEIPADTLGQFPSIKDVL------QAAAAEHQ 373
            + +  R     L + V T +     +  Q + A+  GQ   +++VL      +AAA    
Sbjct: 1776 ALSEARKQSSSLGEQVQTLRGEVADLELQRVEAE--GQLQQLREVLRQRQEGEAAALNTV 1833

Query: 374  DQGQEVNGEVRSRRDSICSSVS-LESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQAL 432
             + Q+    ++ R  S+  +++ LE+   E +   L++ K+++ L   L+ +  E  ++ 
Sbjct: 1834 QKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSH 1893

Query: 433  KEKAELQAQLAALSTKLQ-AQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNML 491
            ++   L A+   L   L  A++E + + +Q Q  L ++V  L+QS    +  +   Q  L
Sbjct: 1894 EDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ-QLEAQVVVLEQSHSPAQLEVDAQQQQL 1952

Query: 492  EAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQ 551
            E     L      L+ A+ Q +R +   E   R        V  L +Q++ L+ QLQQ +
Sbjct: 1953 E-----LQQEVERLRSAQAQTERTLEARERAHR------QRVRGLEEQVSTLKGQLQQ-E 2000

Query: 552  LERTT 556
            L R++
Sbjct: 2001 LRRSS 2005


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  170 bits (430), Expect = 1e-41
 Identities = 245/1098 (22%), Positives = 470/1098 (42%), Gaps = 138/1098 (12%)

Query: 390  ICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKL 449
            +  S   E   A  +EE  +  +E  + E + + L  +    ++EK +LQ Q+ A +  L
Sbjct: 843  LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902

Query: 450  -QAQVECSH--SSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQ 506
              A+  C     ++ + ++   EV    +   ++   +T  +  LE + + L    +DL+
Sbjct: 903  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962

Query: 507  V----AEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLK 562
            +     E++      KV+++   M   D T+  L ++  ALQ   QQ           L+
Sbjct: 963  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT-------LDDLQ 1015

Query: 563  ASQAEISSLQSVRQWYQQQL-----ALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLEN 617
            A + ++++L   +   +QQ+     +L QE ++R+  E A  ++    +      + +EN
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEN 1075

Query: 618  VSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEF 677
                QQL E     +K+K     ++ G+++ + D++A  MQ+Q+    ++  ++   EE 
Sbjct: 1076 D--KQQLDE----KLKKK---EFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEI 1126

Query: 678  EGERERLQRMADSAASLEQQLEQVKLTLLQ----RDQQLEALQQEHLDLMKQLTLTQEAL 733
            E ER    +     + L ++LE++   L +       Q+E  ++   +  K     +EA 
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186

Query: 734  QSREQSLDALQTHYDELQARLGE----LQGEAASREDTICLLQNEKIILEAALQAAKSGK 789
               E +   L+  + +  A LGE    LQ      E     ++ E   L + ++     K
Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAK 1246

Query: 790  EELDRGARRLEEGTEETS----------ETLEKLREELAIKSGQVEHLQQETAALKKQMQ 839
              L++  R LE+   E              L   R  L  +SG+      E   L  Q+ 
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS 1306

Query: 840  KIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQE---LMQVHGEKRT 896
            + K+ F QQ   +E  +R      QL  E+KA +  L   L+  R +   L + + E++ 
Sbjct: 1307 RGKQAFTQQ---IEELKR------QLEEEIKA-KSALAHALQSSRHDCDLLREQYEEEQE 1356

Query: 897  AEAEL----SRLHREVAQVR----------------------QHMADLEGHLQSAQKERD 930
            A+AEL    S+ + EVAQ R                      Q + D E H+++   +  
Sbjct: 1357 AKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCA 1416

Query: 931  EMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQK 990
             +E   Q LQ + E ++   E   A    +++ Q+   K + E KQK     ++L ++QK
Sbjct: 1417 SLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1476

Query: 991  EMKTK-------HKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHER 1043
            E ++          AYE ++  L    +E    ++   ++L +  A+GG         +R
Sbjct: 1477 ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEI-SDLTEQIAEGG---------KR 1526

Query: 1044 IQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE--SRGFRKKIK 1101
            I  LE   + V   K+ L+  L+E  A     LE    K+L ++ EL +  S   RK  +
Sbjct: 1527 IHELEKIKKQVEQEKSELQAALEEAEA----SLEHEEGKILRIQLELNQVKSEVDRKIAE 1582

Query: 1102 RLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQ 1161
            + EE ++   ++  H +   +     +A +R  N  +     K E DL ++ +Q+    +
Sbjct: 1583 KDEEIDQ---MKRNHIRIVESMQSTLDAEIRSRNDAIRLK-KKMEGDLNEMEIQLNHANR 1638

Query: 1162 RKEEEDRQMKH---LVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFK--AASLEL 1216
               E  R  ++   +++  Q  L+        LKEQ+A  +  A   +   +   A+LE 
Sbjct: 1639 MAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1698

Query: 1217 SEVKKELQAKEHL-----VQKLQAEADDLQIREGKHSQEIAQFQAEL---------AEAR 1262
            +E  +++  +E L     VQ L  +   L   + K   +I+Q Q E+         AE +
Sbjct: 1699 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEK 1758

Query: 1263 AQLQLLQ-KQLDEQLSKQPVGNQEMENLKWEVDQKEREIQ-SLKQQLDLTEQQGRKELEG 1320
            A+  +     + E+L K+   +  +E +K  ++Q  +++Q  L +   L  + G+K+++ 
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818

Query: 1321 LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSEL----KNNMKTLLQ-QNQQLKLDLR 1375
            L+  ++ ++ E+E  Q+      K     + KV EL    + + K +L+ Q+   KL  +
Sbjct: 1819 LEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAK 1878

Query: 1376 RGAAKTRKEPKGEASSSN 1393
              + K + E   E S+ N
Sbjct: 1879 VKSYKRQAEEAEEQSNVN 1896



 Score =  164 bits (415), Expect = 6e-40
 Identities = 235/1071 (21%), Positives = 455/1071 (42%), Gaps = 143/1071 (13%)

Query: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSI---CSSVS-----LESSAAETQEEMLQVLK 412
            IK+V + A  E     +E+N E+ +++  +   CS +      LE + A+ ++E      
Sbjct: 923  IKEVTERAEDE-----EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 977

Query: 413  EKMRLEGQLEALSLEASQALKEKAELQA-------QLAALSTKLQAQVECSHSSQQRQDS 465
            +   L  ++  L    ++  KEK  LQ         L A   K+    +     +Q+ D 
Sbjct: 978  KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1037

Query: 466  LSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQR-------LMAK 518
            L   ++  K+   DLERA   L+  L+    S     ND Q  +E+ ++       L +K
Sbjct: 1038 LEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSK 1097

Query: 519  VEDMQRSMLSKDNTVHDLRQQMTALQSQLQ-------QVQLERTTLTSKLK--------- 562
            +ED Q   +     + +L+ ++  L+ +++       + + +R+ L+ +L+         
Sbjct: 1098 IEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1157

Query: 563  --ASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSL 620
              A+ A+I   +     +Q+     +EA ++ +   A ++         L   +++N+  
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE-QIDNLQR 1216

Query: 621  SQQLTETQHRSMK-EKGRIAAQLQGIEADMLDQE----AAFMQIQEAKTMVEEDLQRRLE 675
             +Q  E +   MK E   +A+ ++ +     + E    A   Q+ E KT  EE+ QR + 
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK-EEEQQRLIN 1275

Query: 676  EFEGERERLQ-------RMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTL 728
            +   +R RLQ       R  D   +L  QL + K    Q   Q+E L+++  + +K  + 
Sbjct: 1276 DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQ---QIEELKRQLEEEIKAKSA 1332

Query: 729  TQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSG 788
               ALQS     D L+  Y+E Q    ELQ  A S+ ++           E A    K  
Sbjct: 1333 LAHALQSSRHDCDLLREQYEEEQEAKAELQ-RAMSKANS-----------EVAQWRTKYE 1380

Query: 789  KEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQ 848
             + + R        TEE  E  +KL + L      VE +  + A+L+K  Q+++ +   +
Sbjct: 1381 TDAIQR--------TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV--E 1430

Query: 849  KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV 908
             +M++  R +A       + L   ++  D  L E +Q+  + H E   ++ E   L  E+
Sbjct: 1431 DLMIDVERTNAAC-----AALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485

Query: 909  AQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIE----ELQ 964
             +++    +    L++ ++E   ++  +  L     +        E +KKQ+E    ELQ
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545

Query: 965  ---QEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRR-------LQEAL 1014
               +EA  ++  ++ K+ R+  +L   + E+  K    +  +  + R        +Q  L
Sbjct: 1546 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTL 1605

Query: 1015 AA--KEAADAELGQLRAQGGSSDSSLAL-HERIQALEAELQAVSHSKTLLEKELQEVIAL 1071
             A  +   DA   + + +G  ++  + L H    A EA     +    L + +L    AL
Sbjct: 1606 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665

Query: 1072 TSQE-LEESREKVLELEDELQ-ESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNA 1129
             SQE L+E    V    + LQ E    R  +++ E S K    EL     ++  L   N 
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725

Query: 1130 ALREHNSILETALAKREADLVQLNLQVQAVLQR-KEEEDRQMKHLVQALQASLEKEKEKV 1188
            +L      LET       D+ Q+  +++ ++Q  +  E++  K +  A   + E +KE+ 
Sbjct: 1726 SLINTKKKLET-------DISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQD 1778

Query: 1189 NS-----LKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIR 1243
             S     +K+ +     +  H  R  +A  L L   KK++Q  E  V++L+ E +  Q R
Sbjct: 1779 TSAHLERMKKNLEQTVKDLQH--RLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1836

Query: 1244 EGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSL 1303
                            EA   L+  ++++ E   +     + +  L+  VD+ + +++S 
Sbjct: 1837 N--------------VEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSY 1882

Query: 1304 KQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQE--DLSMTQKDKFMLQAK 1352
            K+Q +  E+Q    L   ++    ++ ELE A+E  D++ +Q +K  ++++
Sbjct: 1883 KRQAEEAEEQSNVNLSKFRR----IQHELEEAEERADIAESQVNKLRVKSR 1929



 Score =  149 bits (376), Expect = 2e-35
 Identities = 232/1156 (20%), Positives = 475/1156 (41%), Gaps = 181/1156 (15%)

Query: 460  QQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNND---LQVAEEQYQRLM 516
            + R + L+  +   +  C     A  + Q M+E + +      N    + V    + +L 
Sbjct: 779  EMRDEKLAQLITRTQAMCRGF-LARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLY 837

Query: 517  AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
             K++ + +S    +  + +++++    + +L + + +R  L  K+     E + LQ   Q
Sbjct: 838  FKIKPLLKSA-ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896

Query: 577  WYQQQLALAQE-------ARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTE--- 626
                 LA A+E        +++L+ ++  +      +  +   L  +   L  + +E   
Sbjct: 897  AEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 956

Query: 627  -------TQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
                   T  +  KEK     +++ +  +M   +    ++ + K  ++E  Q+ L++ + 
Sbjct: 957  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1016

Query: 680  ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEAL------ 733
            E +++  +  +   LEQQ++ ++ +L Q  +    L++    L   L L QE+       
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEND 1076

Query: 734  -QSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEEL 792
             Q  ++ L   +     LQ+++ + Q      +  I  LQ     LE  ++A ++ + + 
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA 1136

Query: 793  DRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV 852
            ++    L    EE SE LE   E     S Q+E  ++  A  +K  + ++E  LQ +   
Sbjct: 1137 EKQRSDLSRELEEISERLE---EAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193

Query: 853  EAYRR----DATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV 908
               R+          + I  L+  +++L+ E  E++ E+  +     T       L +  
Sbjct: 1194 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMC 1253

Query: 909  AQVRQHMADLEGHLQ---------SAQKERDEMETHLQSLQFDKEQMV---------AVT 950
              +   +++++   +         +AQ+ R + E+   S Q D++  +         A T
Sbjct: 1254 RALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFT 1313

Query: 951  EANEALKKQIEE--------------------LQQEARKAITEQKQKMRRLGSDLTSAQK 990
            +  E LK+Q+EE                    L +E  +   E K +++R  S   S   
Sbjct: 1314 QQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVA 1373

Query: 991  EMKTKHKA--------YENAVGILSRRLQEALAAKEAADAELGQL-----RAQGGSSDSS 1037
            + +TK++          E A   L++RLQ+A    EA +A+   L     R Q    D  
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1433

Query: 1038 LALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDEL------- 1090
            + + ER  A  A L     +   +  E ++    T  ELE S+++   L  EL       
Sbjct: 1434 IDV-ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAY 1492

Query: 1091 -----------QESRGFRKKIKRLEE----------SNKKLALELEHEKGKLTGLGQSNA 1129
                       +E++  +++I  L E            +K+  ++E EK +L    +   
Sbjct: 1493 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAE 1552

Query: 1130 ALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMK----HLVQALQASLEKE- 1184
            A  EH    E  + + + +L Q+  +V   +  K+EE  QMK     +V+++Q++L+ E 
Sbjct: 1553 ASLEHE---EGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEI 1609

Query: 1185 ---------KEK----VNSLKEQVAAAK---VEAGHNRR-----------HFKAASLELS 1217
                     K+K    +N ++ Q+  A     EA  N R           H   A     
Sbjct: 1610 RSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQE 1669

Query: 1218 EVKKELQAKEHLVQKLQAEADDLQ--IREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQ 1275
            ++K++L   E     LQAE ++L+  + + + S++IA  + EL +A  ++QLL  Q    
Sbjct: 1670 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA--EQELLDASERVQLLHTQNTSL 1727

Query: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSE---- 1331
            ++ +       + L+ ++ Q + E++ + Q+    E++ +K +     + + +K E    
Sbjct: 1728 INTK-------KKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1780

Query: 1332 --LEMAQEDLSMTQKDKFMLQAKVSELKN-NMKTLLQQNQQLKLDLRRGAAKTRKEPKGE 1388
              LE  +++L  T KD   LQ ++ E +   +K   +Q Q+L+  +R        E +GE
Sbjct: 1781 AHLERMKKNLEQTVKD---LQHRLDEAEQLALKGGKKQIQKLEARVR--------ELEGE 1829

Query: 1389 ASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448
              S        +         ++EL        K  L+ L   + +L+ ++ S +RQ EE
Sbjct: 1830 VESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILR-LQDLVDKLQAKVKSYKRQAEE 1888

Query: 1449 HALTVHESLSSWTPLE 1464
                 + +LS +  ++
Sbjct: 1889 AEEQSNVNLSKFRRIQ 1904



 Score = 67.8 bits (164), Expect = 8e-11
 Identities = 81/421 (19%), Positives = 185/421 (43%), Gaps = 39/421 (9%)

Query: 362  KDVLQAAAAEHQDQGQEVNGEV-RSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL--- 417
            K  LQAA  E +   +   G++ R + +       ++   AE  EE+ Q+ +  +R+   
Sbjct: 1541 KSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVES 1600

Query: 418  -EGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQS 476
             +  L+A     + A++ K +++  L  +      +++ +H+++   ++L +  +T    
Sbjct: 1601 MQSTLDAEIRSRNDAIRLKKKMEGDLNEM------EIQLNHANRMAAEALRNYRNT---- 1650

Query: 477  CWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDL 536
                +  + D Q  L+    S       L + E +   L A++E+++ ++   + +    
Sbjct: 1651 ----QAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1706

Query: 537  RQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEM 596
             Q++     ++Q +  + T+L +  K  + +IS +Q   +   Q+   A+E   +   + 
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDA 1766

Query: 597  AHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAA-----QLQGIEADMLD 651
            A +      +     HL+    +L Q + + QHR + E  ++A      Q+Q +EA + +
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR-LDEAEQLALKGGKKQIQKLEARVRE 1825

Query: 652  QEAAFMQIQEAKTMVEEDL---QRRLEEF----EGERERLQRMADSAASLEQQLEQVKLT 704
             E      Q+      + L   +R+++E     E +R+ + R+ D    L+ +++  K  
Sbjct: 1826 LEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK-- 1883

Query: 705  LLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR 764
                 Q  EA +Q +++L K     Q  L+  E+  D  ++  ++L+ +  E+  +  S 
Sbjct: 1884 ----RQAEEAEEQSNVNLSK-FRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISE 1938

Query: 765  E 765
            E
Sbjct: 1939 E 1939


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  169 bits (429), Expect = 1e-41
 Identities = 242/1094 (22%), Positives = 463/1094 (42%), Gaps = 126/1094 (11%)

Query: 390  ICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKL 449
            +  S   E   A  +EE  ++  E  + E + + L  +    LKEK +LQ Q+ A +  L
Sbjct: 845  LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 450  -QAQVECSH--SSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQ 506
              A+  C     ++ + ++   EV    +   ++   +T  +  LE + + L    +DL+
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 507  V----AEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLK 562
            +     E++      KV+++   M   D T+  L ++  ALQ   QQ           L+
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT-------LDDLQ 1017

Query: 563  ASQAEISSLQSVRQWYQQQL-----ALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLEN 617
            A + ++++L   +   +QQ+     +L QE ++R+  E A        +  L   LKL  
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERA--------KRKLEGDLKLAQ 1069

Query: 618  VSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEF 677
             S+     E Q    K K +   ++  +++ + D++A  +Q+Q+    ++  ++   EE 
Sbjct: 1070 ESIMDIENEKQQLDEKLKKK-EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128

Query: 678  EGERERLQRMADSAASLEQQLEQVKLTLLQ----RDQQLEALQQEHLDLMKQLTLTQEAL 733
            E ER    +     + L ++LE++   L +       Q+E  ++   +  K     +EA 
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188

Query: 734  QSREQSLDALQTHYDELQARLGE----LQGEAASREDTICLLQNEKIILEAALQAAKSGK 789
               E +   L+  + +  A LGE    LQ      E     ++ E   L + ++     K
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248

Query: 790  EELDRGARRLEEGTEETSETLEK----------LREELAIKSGQVEHLQQETAALKKQMQ 839
              L++  R LE+   E     E+           R  L  +SG+      E  AL  Q+ 
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS 1308

Query: 840  KIKEQFLQQ-KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAE 898
            + K+ F QQ + +      +  +K+ L   L+++R   D     LR++  +    K   +
Sbjct: 1309 RGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL----LREQYEEEQESKAELQ 1364

Query: 899  AELSRLHREVAQVR----------------------QHMADLEGHLQSAQKERDEMETHL 936
              LS+ + EVAQ R                      Q +   E H+++   +   +E   
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 937  QSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTK- 995
            Q LQ + E ++   E   A    +++ Q+   K + E KQK     ++L ++QKE ++  
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484

Query: 996  ------HKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEA 1049
                    AYE ++  L    +E    ++   ++L +  A+GG         +RI  LE 
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEI-SDLTEQIAEGG---------KRIHELEK 1534

Query: 1050 ELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE--SRGFRKKIKRLEESN 1107
              + V   K  L+  L+E  A     LE    K+L ++ EL +  S   RK  ++ EE +
Sbjct: 1535 IKKQVEQEKCELQAALEEAEA----SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590

Query: 1108 KKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEED 1167
            +   L+  H +   +     +A +R  N  +     K E DL ++ +Q+    +   E  
Sbjct: 1591 Q---LKRNHIRIVESMQSTLDAEIRSRNDAIRLK-KKMEGDLNEMEIQLNHANRMAAEAL 1646

Query: 1168 RQMKH---LVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFK--AASLELSEVKKE 1222
            R  ++   +++  Q  L+        LKEQ+A  +  A   +   +   A+LE +E  ++
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706

Query: 1223 LQAKEHL-----VQKLQAEADDLQIREGKHSQEIAQFQAE----LAEARAQLQLLQK--- 1270
            +  +E L     VQ L  +   L   + K   +I+Q Q E    L EAR   +  +K   
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAIT 1766

Query: 1271 ---QLDEQLSKQPVGNQEMENLKWEVDQKEREIQ-SLKQQLDLTEQQGRKELEGLQQLLQ 1326
                + E+L K+   +  +E +K  ++Q  +++Q  L +   L  + G+K+++ L+  ++
Sbjct: 1767 DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826

Query: 1327 NVKSELEMAQEDLSMTQKDKFMLQAKVSEL----KNNMKTLLQ-QNQQLKLDLRRGAAKT 1381
             ++ E+E  Q+  +   K     + +V EL    + + K +L+ Q+   KL  +  + K 
Sbjct: 1827 ELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1886

Query: 1382 RKEPKGEASSSNPA 1395
            + E   E S++N A
Sbjct: 1887 QAEEAEEQSNTNLA 1900



 Score =  159 bits (403), Expect = 1e-38
 Identities = 240/1077 (22%), Positives = 447/1077 (41%), Gaps = 155/1077 (14%)

Query: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVS-LESSAAETQEEMLQVLKEKMRLEG 419
            IK+V + A  E     +E+N E+ +++  +    S L+    + +  + +V KEK   E 
Sbjct: 925  IKEVTERAEDE-----EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979

Query: 420  QLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSE---VDTLKQS 476
            +++ L+       +E A L   +A L+ + +A  E   + QQ  D L +E   V+TL ++
Sbjct: 980  KVKNLT-------EEMAGLDETIAKLTKEKKALQE---AHQQTLDDLQAEEDKVNTLTKA 1029

Query: 477  CWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDL 536
               LE+ + DL+  LE +           +  E   +     + D++      D  +   
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089

Query: 537  RQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEM 596
              +++ LQS+++  Q     L  K+K  QA I  L+   +  +   A A++ R  L  E+
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149

Query: 597  AHI-----QVGQMTQAGL----------------LEHLKLENVSLSQQLTETQHRSMKEK 635
              I     + G  T A +                LE   L++ + +  L +    S+ E 
Sbjct: 1150 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1209

Query: 636  GRIAAQLQGIEADMLDQEAAFM------------------------------QIQEAKTM 665
            G     LQ ++   L++E + M                              Q+ E K+ 
Sbjct: 1210 GEQIDNLQRVK-QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268

Query: 666  VEEDLQRRLEEFEGERERLQ-------RMADSAASLEQQLEQVKLTLLQRDQQLEALQQE 718
             EE+ QR + +   +R RLQ       R  D   +L  QL + K       QQ+E L+++
Sbjct: 1269 -EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAF---TQQIEELKRQ 1324

Query: 719  HLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIIL 778
              + +K       ALQS     D L+  Y+E Q    ELQ  A S+ +T           
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ-RALSKANT----------- 1372

Query: 779  EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQM 838
            E A    K   + + R        TEE  E  +KL + L      VE +  + A+L+K  
Sbjct: 1373 EVAQWRTKYETDAIQR--------TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 839  QKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAE 898
            Q+++ +       VE    D    +   + L   ++  D  L E +Q+  + H E   ++
Sbjct: 1425 QRLQNE-------VEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477

Query: 899  AELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKK 958
             E   L  E+ +++    +    L++ ++E   ++  +  L     +        E +KK
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537

Query: 959  QIE----ELQ---QEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR--- 1008
            Q+E    ELQ   +EA  ++  ++ K+ R+  +L   + E+  K    +  +  L R   
Sbjct: 1538 QVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHI 1597

Query: 1009 RLQEALAA------KEAADAELGQLRAQGGSSDSSLAL-HERIQALEAELQAVSHSKTLL 1061
            R+ E++ +      +   DA   + + +G  ++  + L H    A EA     +    L 
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657

Query: 1062 EKELQEVIALTSQE-LEESREKVLELEDELQ-ESRGFRKKIKRLEESNKKLALELEHEKG 1119
            + ++    AL SQE L+E    V    + LQ E    R  +++ E S K    EL     
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717

Query: 1120 KLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR-KEEEDRQMKHLVQALQ 1178
            ++  L   N +L      LET       D+ Q+  +++ +LQ  +  E++  K +  A  
Sbjct: 1718 RVQLLHTQNTSLINTKKKLET-------DISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770

Query: 1179 ASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKK-ELQAKEHLVQKLQAEA 1237
             + E +KE+  S   +     +E     +  K   L L E ++  L+  +  +QKL+A  
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNME-----QTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1825

Query: 1238 DDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKE 1297
             +L+        E+   Q   AEA   L+  ++++ E   +     + +  L+  VD+ +
Sbjct: 1826 RELE-------GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQ 1878

Query: 1298 REIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQE--DLSMTQKDKFMLQAK 1352
             +++S K+Q +  E+Q    L   ++L    + ELE A+E  D++ +Q +K  ++++
Sbjct: 1879 AKVKSYKRQAEEAEEQSNTNLAKFRKL----QHELEEAEERADIAESQVNKLRVKSR 1931



 Score =  152 bits (385), Expect = 2e-36
 Identities = 241/1159 (20%), Positives = 481/1159 (41%), Gaps = 187/1159 (16%)

Query: 460  QQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNND---LQVAEEQYQRLM 516
            + R D L+  +   +  C     A  + Q M+E + A      N    + V    + +L 
Sbjct: 781  EMRDDKLAQLITRTQARCRGF-LARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLF 839

Query: 517  AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
             K++ + +S    +  +  ++++   ++ +L + + +R  L  K+     E + LQ   Q
Sbjct: 840  FKIKPLLKSA-ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 898

Query: 577  WYQQQLALAQE-------ARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTE--- 626
               + LA A+E        +++L+ ++  +      +  +   L  +   L  + +E   
Sbjct: 899  AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958

Query: 627  -------TQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
                   T  +  KEK     +++ +  +M   +    ++ + K  ++E  Q+ L++ + 
Sbjct: 959  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1018

Query: 680  ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEAL------ 733
            E +++  +  +   LEQQ++ ++ +L Q  +    L++    L   L L QE++      
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE 1078

Query: 734  -QSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEEL 792
             Q  ++ L   +     LQ+++ + Q      +  I  LQ     LE  ++A ++ + + 
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138

Query: 793  DRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV 852
            ++    L    EE SE LE   E     S Q+E  ++  A  +K  + ++E  LQ +   
Sbjct: 1139 EKQRSDLSRELEEISERLE---EAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 853  EAYRR----DATSKDQLISELKATRKRLDSELKELRQELMQVHG------------EK-- 894
               R+          + I  L+  +++L+ E  E++ E+  +              EK  
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 895  RTAEAELSRLHREVAQVRQHMADL---EGHLQSA----QKERDEMETHLQSLQFDKEQMV 947
            RT E +LS L  +  + ++ + DL    G LQ+      ++ DE E  +  L   K+   
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQ--- 1312

Query: 948  AVTEANEALKKQIEE--------------------LQQEARKAITEQKQKMRRLGSDLTS 987
            A T+  E LK+Q+EE                    L +E  +   E K +++R  S   +
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372

Query: 988  AQKEMKTKHKA--------YENAVGILSRRLQEALAAKEAADAELGQL-----RAQGGSS 1034
               + +TK++          E A   L++RLQ A    EA +A+   L     R Q    
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432

Query: 1035 DSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDEL---- 1090
            D  L + ER  A  A L     +   +  E ++    T  ELE S+++   L  EL    
Sbjct: 1433 DLMLDV-ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIK 1491

Query: 1091 --------------QESRGFRKKIKRLEE----------SNKKLALELEHEKGKLTGLGQ 1126
                          +E++  +++I  L E            +K+  ++E EK +L    +
Sbjct: 1492 NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALE 1551

Query: 1127 SNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMK----HLVQALQASLE 1182
               A  EH    E  + + + +L Q+  +V   +  K+EE  Q+K     +V+++Q++L+
Sbjct: 1552 EAEASLEHE---EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608

Query: 1183 KE----------KEK----VNSLKEQVAAAK---VEAGHNRR-----------HFKAASL 1214
             E          K+K    +N ++ Q+  A     EA  N R           H   A  
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668

Query: 1215 ELSEVKKELQAKEHLVQKLQAEADDLQ--IREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
               ++K++L   E     LQAE ++L+  + + + S++IA  + EL +A  ++QLL  Q 
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA--EQELLDASERVQLLHTQN 1726

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSE- 1331
               ++ +       + L+ ++ Q + E++ + Q+    E++ +K +     + + +K E 
Sbjct: 1727 TSLINTK-------KKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779

Query: 1332 -----LEMAQEDLSMTQKDKFMLQAKVSELKN-NMKTLLQQNQQLKLDLRRGAAKTRKEP 1385
                 LE  ++++  T KD   LQ ++ E +   +K   +Q Q+L+  +R        E 
Sbjct: 1780 DTSAHLERMKKNMEQTVKD---LQLRLDEAEQLALKGGKKQIQKLEARVR--------EL 1828

Query: 1386 KGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQ 1445
            +GE  S        +         ++EL        K  L+ L   + +L+ ++ S +RQ
Sbjct: 1829 EGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILR-LQDLVDKLQAKVKSYKRQ 1887

Query: 1446 MEEHALTVHESLSSWTPLE 1464
             EE     + +L+ +  L+
Sbjct: 1888 AEEAEEQSNTNLAKFRKLQ 1906


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  169 bits (429), Expect = 1e-41
 Identities = 242/1094 (22%), Positives = 463/1094 (42%), Gaps = 126/1094 (11%)

Query: 390  ICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKL 449
            +  S   E   A  +EE  ++  E  + E + + L  +    LKEK +LQ Q+ A +  L
Sbjct: 845  LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 450  -QAQVECSH--SSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQ 506
              A+  C     ++ + ++   EV    +   ++   +T  +  LE + + L    +DL+
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 507  V----AEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLK 562
            +     E++      KV+++   M   D T+  L ++  ALQ   QQ           L+
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT-------LDDLQ 1017

Query: 563  ASQAEISSLQSVRQWYQQQL-----ALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLEN 617
            A + ++++L   +   +QQ+     +L QE ++R+  E A        +  L   LKL  
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERA--------KRKLEGDLKLAQ 1069

Query: 618  VSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEF 677
             S+     E Q    K K +   ++  +++ + D++A  +Q+Q+    ++  ++   EE 
Sbjct: 1070 ESIMDIENEKQQLDEKLKKK-EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128

Query: 678  EGERERLQRMADSAASLEQQLEQVKLTLLQ----RDQQLEALQQEHLDLMKQLTLTQEAL 733
            E ER    +     + L ++LE++   L +       Q+E  ++   +  K     +EA 
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188

Query: 734  QSREQSLDALQTHYDELQARLGE----LQGEAASREDTICLLQNEKIILEAALQAAKSGK 789
               E +   L+  + +  A LGE    LQ      E     ++ E   L + ++     K
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248

Query: 790  EELDRGARRLEEGTEETSETLEK----------LREELAIKSGQVEHLQQETAALKKQMQ 839
              L++  R LE+   E     E+           R  L  +SG+      E  AL  Q+ 
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS 1308

Query: 840  KIKEQFLQQ-KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAE 898
            + K+ F QQ + +      +  +K+ L   L+++R   D     LR++  +    K   +
Sbjct: 1309 RGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL----LREQYEEEQESKAELQ 1364

Query: 899  AELSRLHREVAQVR----------------------QHMADLEGHLQSAQKERDEMETHL 936
              LS+ + EVAQ R                      Q +   E H+++   +   +E   
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 937  QSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTK- 995
            Q LQ + E ++   E   A    +++ Q+   K + E KQK     ++L ++QKE ++  
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484

Query: 996  ------HKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEA 1049
                    AYE ++  L    +E    ++   ++L +  A+GG         +RI  LE 
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEI-SDLTEQIAEGG---------KRIHELEK 1534

Query: 1050 ELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE--SRGFRKKIKRLEESN 1107
              + V   K  L+  L+E  A     LE    K+L ++ EL +  S   RK  ++ EE +
Sbjct: 1535 IKKQVEQEKCELQAALEEAEA----SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590

Query: 1108 KKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEED 1167
            +   L+  H +   +     +A +R  N  +     K E DL ++ +Q+    +   E  
Sbjct: 1591 Q---LKRNHIRIVESMQSTLDAEIRSRNDAIRLK-KKMEGDLNEMEIQLNHANRMAAEAL 1646

Query: 1168 RQMKH---LVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFK--AASLELSEVKKE 1222
            R  ++   +++  Q  L+        LKEQ+A  +  A   +   +   A+LE +E  ++
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706

Query: 1223 LQAKEHL-----VQKLQAEADDLQIREGKHSQEIAQFQAE----LAEARAQLQLLQK--- 1270
            +  +E L     VQ L  +   L   + K   +I+Q Q E    L EAR   +  +K   
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAIT 1766

Query: 1271 ---QLDEQLSKQPVGNQEMENLKWEVDQKEREIQ-SLKQQLDLTEQQGRKELEGLQQLLQ 1326
                + E+L K+   +  +E +K  ++Q  +++Q  L +   L  + G+K+++ L+  ++
Sbjct: 1767 DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826

Query: 1327 NVKSELEMAQEDLSMTQKDKFMLQAKVSEL----KNNMKTLLQ-QNQQLKLDLRRGAAKT 1381
             ++ E+E  Q+  +   K     + +V EL    + + K +L+ Q+   KL  +  + K 
Sbjct: 1827 ELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1886

Query: 1382 RKEPKGEASSSNPA 1395
            + E   E S++N A
Sbjct: 1887 QAEEAEEQSNTNLA 1900



 Score =  159 bits (403), Expect = 1e-38
 Identities = 240/1077 (22%), Positives = 447/1077 (41%), Gaps = 155/1077 (14%)

Query: 361  IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVS-LESSAAETQEEMLQVLKEKMRLEG 419
            IK+V + A  E     +E+N E+ +++  +    S L+    + +  + +V KEK   E 
Sbjct: 925  IKEVTERAEDE-----EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979

Query: 420  QLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSE---VDTLKQS 476
            +++ L+       +E A L   +A L+ + +A  E   + QQ  D L +E   V+TL ++
Sbjct: 980  KVKNLT-------EEMAGLDETIAKLTKEKKALQE---AHQQTLDDLQAEEDKVNTLTKA 1029

Query: 477  CWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDL 536
               LE+ + DL+  LE +           +  E   +     + D++      D  +   
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089

Query: 537  RQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEM 596
              +++ LQS+++  Q     L  K+K  QA I  L+   +  +   A A++ R  L  E+
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149

Query: 597  AHI-----QVGQMTQAGL----------------LEHLKLENVSLSQQLTETQHRSMKEK 635
              I     + G  T A +                LE   L++ + +  L +    S+ E 
Sbjct: 1150 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1209

Query: 636  GRIAAQLQGIEADMLDQEAAFM------------------------------QIQEAKTM 665
            G     LQ ++   L++E + M                              Q+ E K+ 
Sbjct: 1210 GEQIDNLQRVK-QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268

Query: 666  VEEDLQRRLEEFEGERERLQ-------RMADSAASLEQQLEQVKLTLLQRDQQLEALQQE 718
             EE+ QR + +   +R RLQ       R  D   +L  QL + K       QQ+E L+++
Sbjct: 1269 -EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAF---TQQIEELKRQ 1324

Query: 719  HLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIIL 778
              + +K       ALQS     D L+  Y+E Q    ELQ  A S+ +T           
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ-RALSKANT----------- 1372

Query: 779  EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQM 838
            E A    K   + + R        TEE  E  +KL + L      VE +  + A+L+K  
Sbjct: 1373 EVAQWRTKYETDAIQR--------TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 839  QKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAE 898
            Q+++ +       VE    D    +   + L   ++  D  L E +Q+  + H E   ++
Sbjct: 1425 QRLQNE-------VEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477

Query: 899  AELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKK 958
             E   L  E+ +++    +    L++ ++E   ++  +  L     +        E +KK
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537

Query: 959  QIE----ELQ---QEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR--- 1008
            Q+E    ELQ   +EA  ++  ++ K+ R+  +L   + E+  K    +  +  L R   
Sbjct: 1538 QVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHI 1597

Query: 1009 RLQEALAA------KEAADAELGQLRAQGGSSDSSLAL-HERIQALEAELQAVSHSKTLL 1061
            R+ E++ +      +   DA   + + +G  ++  + L H    A EA     +    L 
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657

Query: 1062 EKELQEVIALTSQE-LEESREKVLELEDELQ-ESRGFRKKIKRLEESNKKLALELEHEKG 1119
            + ++    AL SQE L+E    V    + LQ E    R  +++ E S K    EL     
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717

Query: 1120 KLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR-KEEEDRQMKHLVQALQ 1178
            ++  L   N +L      LET       D+ Q+  +++ +LQ  +  E++  K +  A  
Sbjct: 1718 RVQLLHTQNTSLINTKKKLET-------DISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770

Query: 1179 ASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKK-ELQAKEHLVQKLQAEA 1237
             + E +KE+  S   +     +E     +  K   L L E ++  L+  +  +QKL+A  
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNME-----QTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1825

Query: 1238 DDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKE 1297
             +L+        E+   Q   AEA   L+  ++++ E   +     + +  L+  VD+ +
Sbjct: 1826 RELE-------GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQ 1878

Query: 1298 REIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQE--DLSMTQKDKFMLQAK 1352
             +++S K+Q +  E+Q    L   ++L    + ELE A+E  D++ +Q +K  ++++
Sbjct: 1879 AKVKSYKRQAEEAEEQSNTNLAKFRKL----QHELEEAEERADIAESQVNKLRVKSR 1931



 Score =  152 bits (385), Expect = 2e-36
 Identities = 241/1159 (20%), Positives = 481/1159 (41%), Gaps = 187/1159 (16%)

Query: 460  QQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNND---LQVAEEQYQRLM 516
            + R D L+  +   +  C     A  + Q M+E + A      N    + V    + +L 
Sbjct: 781  EMRDDKLAQLITRTQARCRGF-LARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLF 839

Query: 517  AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
             K++ + +S    +  +  ++++   ++ +L + + +R  L  K+     E + LQ   Q
Sbjct: 840  FKIKPLLKSA-ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 898

Query: 577  WYQQQLALAQE-------ARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTE--- 626
               + LA A+E        +++L+ ++  +      +  +   L  +   L  + +E   
Sbjct: 899  AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958

Query: 627  -------TQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
                   T  +  KEK     +++ +  +M   +    ++ + K  ++E  Q+ L++ + 
Sbjct: 959  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1018

Query: 680  ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEAL------ 733
            E +++  +  +   LEQQ++ ++ +L Q  +    L++    L   L L QE++      
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE 1078

Query: 734  -QSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEEL 792
             Q  ++ L   +     LQ+++ + Q      +  I  LQ     LE  ++A ++ + + 
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138

Query: 793  DRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV 852
            ++    L    EE SE LE   E     S Q+E  ++  A  +K  + ++E  LQ +   
Sbjct: 1139 EKQRSDLSRELEEISERLE---EAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 853  EAYRR----DATSKDQLISELKATRKRLDSELKELRQELMQVHG------------EK-- 894
               R+          + I  L+  +++L+ E  E++ E+  +              EK  
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 895  RTAEAELSRLHREVAQVRQHMADL---EGHLQSA----QKERDEMETHLQSLQFDKEQMV 947
            RT E +LS L  +  + ++ + DL    G LQ+      ++ DE E  +  L   K+   
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQ--- 1312

Query: 948  AVTEANEALKKQIEE--------------------LQQEARKAITEQKQKMRRLGSDLTS 987
            A T+  E LK+Q+EE                    L +E  +   E K +++R  S   +
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372

Query: 988  AQKEMKTKHKA--------YENAVGILSRRLQEALAAKEAADAELGQL-----RAQGGSS 1034
               + +TK++          E A   L++RLQ A    EA +A+   L     R Q    
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432

Query: 1035 DSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDEL---- 1090
            D  L + ER  A  A L     +   +  E ++    T  ELE S+++   L  EL    
Sbjct: 1433 DLMLDV-ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIK 1491

Query: 1091 --------------QESRGFRKKIKRLEE----------SNKKLALELEHEKGKLTGLGQ 1126
                          +E++  +++I  L E            +K+  ++E EK +L    +
Sbjct: 1492 NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALE 1551

Query: 1127 SNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMK----HLVQALQASLE 1182
               A  EH    E  + + + +L Q+  +V   +  K+EE  Q+K     +V+++Q++L+
Sbjct: 1552 EAEASLEHE---EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608

Query: 1183 KE----------KEK----VNSLKEQVAAAK---VEAGHNRR-----------HFKAASL 1214
             E          K+K    +N ++ Q+  A     EA  N R           H   A  
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668

Query: 1215 ELSEVKKELQAKEHLVQKLQAEADDLQ--IREGKHSQEIAQFQAELAEARAQLQLLQKQL 1272
               ++K++L   E     LQAE ++L+  + + + S++IA  + EL +A  ++QLL  Q 
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA--EQELLDASERVQLLHTQN 1726

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSE- 1331
               ++ +       + L+ ++ Q + E++ + Q+    E++ +K +     + + +K E 
Sbjct: 1727 TSLINTK-------KKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779

Query: 1332 -----LEMAQEDLSMTQKDKFMLQAKVSELKN-NMKTLLQQNQQLKLDLRRGAAKTRKEP 1385
                 LE  ++++  T KD   LQ ++ E +   +K   +Q Q+L+  +R        E 
Sbjct: 1780 DTSAHLERMKKNMEQTVKD---LQLRLDEAEQLALKGGKKQIQKLEARVR--------EL 1828

Query: 1386 KGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQ 1445
            +GE  S        +         ++EL        K  L+ L   + +L+ ++ S +RQ
Sbjct: 1829 EGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILR-LQDLVDKLQAKVKSYKRQ 1887

Query: 1446 MEEHALTVHESLSSWTPLE 1464
             EE     + +L+ +  L+
Sbjct: 1888 AEEAEEQSNTNLAKFRKLQ 1906


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  169 bits (428), Expect = 2e-41
 Identities = 243/1131 (21%), Positives = 467/1131 (41%), Gaps = 148/1131 (13%)

Query: 358  FPSIKDVLQAAAAEH--QDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKM 415
            F  +K +LQ    +   Q + QE+      ++ S      L+   A+ +EE  + L E++
Sbjct: 863  FTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERAR-LAEQL 921

Query: 416  RLEGQLEALSLEASQALK-EKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLK 474
            R E +L A + E    L   K EL+  ++ L  ++  + ECS   Q  +  L   +  L+
Sbjct: 922  RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 981

Query: 475  QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMA----------------- 517
                  E A   LQ       A +     DL + E+Q  +L                   
Sbjct: 982  AHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAA 1041

Query: 518  ----KVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQS 573
                KV+ + +  L  + T+ D+  ++   +   Q+++  +  L  +    Q ++   Q 
Sbjct: 1042 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1101

Query: 574  VRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSL--------SQQLT 625
              +  + QL   +E    LQ  +A  +     +A LL+ L+    +L        S+++ 
Sbjct: 1102 RAEELRAQLGRKEE---ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVA 1158

Query: 626  ETQ-HRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFE-----G 679
             T+  +  ++ G     L+G   D LD   A  +++  +     +L++ LEE        
Sbjct: 1159 RTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAA 1218

Query: 680  ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQS 739
             +E  QR   +   L +QLEQ +      ++   AL+ E  +L  +L+  Q A Q  EQ 
Sbjct: 1219 VQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQR 1278

Query: 740  LDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRL 799
               L+    E+Q R G+ +   A   + +   Q E   +  AL  A+S    L +     
Sbjct: 1279 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1338

Query: 800  EEGTEETSETL-EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRD 858
            E    +  E L E+ R +LA+ S +V  ++ E A L++Q+++                 +
Sbjct: 1339 EAQLHDAQELLQEETRAKLALGS-RVRAMEAEAAGLREQLEE-----------------E 1380

Query: 859  ATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADL 918
            A ++++   EL+  +    ++L E R+   +  G     E    R  RE   + Q +A+ 
Sbjct: 1381 AAARERAGRELQTAQ----AQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1436

Query: 919  EGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAI---TEQK 975
               +   ++ R  ++  L     D EQ   +    E  +++ ++L  E + A+    E++
Sbjct: 1437 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1496

Query: 976  QKMRRLGSD-------LTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQL- 1027
            ++    G +       LT A +E +   +  E     L   L+  L++K+     + +L 
Sbjct: 1497 ERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELE 1556

Query: 1028 RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQEL--------EES 1079
            RA   +  ++  L  ++  LE EL A   +K  LE  +Q +     ++L        E  
Sbjct: 1557 RACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1616

Query: 1080 REKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN----------- 1128
            R+   +L D   E    RK+      + KKL  ELE  K ++   GQ             
Sbjct: 1617 RQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQ 1676

Query: 1129 AALRE-----------------HNSILETALAKREADLVQLNLQVQAV--LQRKEEEDR- 1168
            A ++E                  N   E  L   EA++++L  ++ A    +R+ ++DR 
Sbjct: 1677 AQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRD 1736

Query: 1169 ----QMKHLVQALQASLEKEKE---KVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKK 1221
                ++ +   +  A LE++++   ++  L+E++   +  +      ++   L++  +  
Sbjct: 1737 EMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT 1796

Query: 1222 ELQAKEHLV-------QKLQAEADDLQIREG--------KHSQEIAQFQAELAEARAQLQ 1266
            EL A+           Q+L+ +  +L+ R G        +H   IA  +++LA+A  QL+
Sbjct: 1797 ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1856

Query: 1267 LLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQ 1326
              Q+  +  LS + V   E + LK  V Q E E +           Q R +LE     ++
Sbjct: 1857 --QETRERILSGKLVRRAE-KRLKEVVLQVEEERR--------VADQLRDQLEKGNLRVK 1905

Query: 1327 NVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRG 1377
             +K +LE A+E+ S  Q  +  LQ ++ ++  + +++ ++   L+  LRRG
Sbjct: 1906 QLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG 1956



 Score =  147 bits (370), Expect = 1e-34
 Identities = 228/1075 (21%), Positives = 445/1075 (41%), Gaps = 158/1075 (14%)

Query: 432  LKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSC--------WDLERA 483
            L+E+ +L+     +S +  A+   +  + Q++    S +  ++++C        W   R 
Sbjct: 803  LEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRL 862

Query: 484  MTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTA- 542
             T ++ +L+                  Q + L A+ +++Q+        V +L+QQ    
Sbjct: 863  FTKVKPLLQVTR---------------QDEVLQARAQELQK--------VQELQQQSARE 899

Query: 543  ---LQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHI 599
               LQ ++ Q++ ER  L  +L+A +AE+              A A+E R RL      +
Sbjct: 900  VGELQGRVAQLEEERARLAEQLRA-EAELC-------------AEAEETRGRLAARKQEL 945

Query: 600  QVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQI 659
            ++        LE    E    S+Q+         EK R+   +Q +EA +  +E A  ++
Sbjct: 946  EL----VVSELEARVGEEEECSRQM-------QTEKKRLQQHIQELEAHLEAEEGARQKL 994

Query: 660  QEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEH 719
            Q  K   E  +++  E+     ++  +++     LE +L +      + ++++++L +  
Sbjct: 995  QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLR 1054

Query: 720  LDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILE 779
            L     +   ++ L+  E+    L+     L     ELQ +   ++     L+ +    E
Sbjct: 1055 LKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1114

Query: 780  AALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQ 839
              LQAA +  E+      +L +   E    L + +E+L  +       +++   L ++++
Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE 1174

Query: 840  KIKEQFLQQKVMVEAYRRDATSKDQLISELKAT---------------RKRLDSELKELR 884
             ++ +         A +   + ++Q ++ELK T               R+R    L EL 
Sbjct: 1175 ALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELA 1234

Query: 885  QELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQ---F 941
            ++L Q    K   E     L  EV+++R  ++ L+   Q  ++ R  +E  LQ +Q    
Sbjct: 1235 EQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAG 1294

Query: 942  DKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMK-------- 993
            D E+  A  EA E L++   EL +    A+ E + K  RL  +L+S + ++         
Sbjct: 1295 DGER--ARAEAAEKLQRAQAEL-ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQE 1351

Query: 994  ---------TKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERI 1044
                     ++ +A E     L  +L+E  AA+E A  EL   +AQ   S+      E  
Sbjct: 1352 ETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ--LSEWRRRQEEEA 1409

Query: 1045 QALEAELQAVSHSKTLLEKELQEVIALTS--QELEESREKV-LELEDELQESRGFRKKIK 1101
             ALEA  +A   +    E   Q +   T     LE  R ++  EL+D   +    R+ + 
Sbjct: 1410 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1469

Query: 1102 RLEESNKKLALELEHEKGKLTGLGQSNAALR--EHNSILETALAKREADLVQLNLQVQAV 1159
             LE+  +K    L  EK          A LR  E     E    +REA  + L   ++  
Sbjct: 1470 TLEKKQRKFDQLLAEEKA---------AVLRAVEERERAEAEGREREARALSLTRALEEE 1520

Query: 1160 LQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKV--EAGHNRRHFKAASLELS 1217
             + +EE +RQ + L   L+A L  + +   S+ E   A +V  +A ++ R       +++
Sbjct: 1521 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR------AQVT 1574

Query: 1218 EVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEAR-----AQLQLLQKQL 1272
            E++ EL A E    +L+     +Q  + +H +++ Q + E  E R      QL+  + + 
Sbjct: 1575 ELEDELTAAEDAKLRLEV---TVQALKTQHERDL-QGRDEAGEERRRQLAKQLRDAEVER 1630

Query: 1273 DEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL 1332
            DE+  ++ +     + L+ E+++ + ++ S  Q  +   +Q RK    +++L + V+   
Sbjct: 1631 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1690

Query: 1333 EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSS 1392
               +E  S  ++ +  L+   +E+       LQ+        RR A + R E   E ++ 
Sbjct: 1691 TSREEIFSQNRESEKRLKGLEAEVLR-----LQEELAASDRARRQAQQDRDEMADEVANG 1745

Query: 1393 NPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQME 1447
            N +           A++LEE             + L   L QL++E++  Q   E
Sbjct: 1746 NLS----------KAAILEE------------KRQLEGRLGQLEEELEEEQSNSE 1778



 Score =  137 bits (345), Expect = 8e-32
 Identities = 188/862 (21%), Positives = 357/862 (41%), Gaps = 103/862 (11%)

Query: 664  TMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLM 723
            T  +E LQ R +E +  +E  Q+ A     L+ ++ Q              L++E   L 
Sbjct: 873  TRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQ--------------LEEERARLA 918

Query: 724  KQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQ 783
            +QL    E     E++   L     EL+  + EL+      E+    +Q EK  L+  +Q
Sbjct: 919  EQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQ 978

Query: 784  AAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKE 843
              ++  E  +   ++L+     T   ++K  E+L +   Q   L +E   L+ ++ +   
Sbjct: 979  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038

Query: 844  QFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSR 903
            Q  +++  V++  +     +  I++++   ++ +   +EL +   ++ GE    + ++  
Sbjct: 1039 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1098

Query: 904  LHREVAQVRQHMADLEGHLQSA-QKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEE 962
              +   ++R  +   E  LQ+A  +  DE     Q L+  +E   A+ EA E L+ +   
Sbjct: 1099 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE--- 1155

Query: 963  LQQEARKAITEQKQKMRRLGSDL-------------TSAQKEMKTKHKAYENAVGILSRR 1009
                 R A T+ +++ R LG +L             T+AQ+E+++K    E  V  L + 
Sbjct: 1156 -----RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR---EQEVTELKKT 1207

Query: 1010 LQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVI 1069
            L+E     EAA  EL Q   Q         L E+++       A   ++  LE E+ E+ 
Sbjct: 1208 LEEETRIHEAAVQELRQRHGQALGE-----LAEQLEQARRGKGAWEKTRLALEAEVSELR 1262

Query: 1070 A-----LTSQELEESREKVLELEDELQESRGFRKKIKRLEESNK--KLALELEHEKGKLT 1122
            A      T+++  E R + LEL+ +  + R    +  R E + K  +   ELE+  G L 
Sbjct: 1263 AELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALN 1322

Query: 1123 GLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
                    L +  S  E  L   + +L+Q   + +  L  +    R M+     L+  LE
Sbjct: 1323 EAESKTIRLSKELSSTEAQLHDAQ-ELLQEETRAKLALGSRV---RAMEAEAAGLREQLE 1378

Query: 1183 KE---KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK--EHLVQKLQAE- 1236
            +E   +E+    + Q A A++     R+  +A +LE  E  +   A+  E L Q+L  + 
Sbjct: 1379 EEAAARERAGR-ELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKT 1437

Query: 1237 --ADDLQIREGKHSQEIAQFQAELAEAR---AQLQLLQKQLDEQLS--KQPVGNQEMENL 1289
               D L+    +  QE+     +L + R   + L+  Q++ D+ L+  K  V     E  
Sbjct: 1438 ETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERE 1497

Query: 1290 KWEVDQKEREIQSLKQQLDLTEQQG------------RKELEGL---------------- 1321
            + E + +ERE ++L     L E+Q             R ELE L                
Sbjct: 1498 RAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELER 1557

Query: 1322 -----QQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRR 1376
                 +Q   ++++++   +++L+  +  K  L+  V  LK   +  LQ   +   + RR
Sbjct: 1558 ACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRR 1617

Query: 1377 GAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLK 1436
              AK  ++ + E         + +         LEE L+   A + +  +     L++++
Sbjct: 1618 QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEEAVKQLRKMQ 1676

Query: 1437 QEMDSLQRQMEEHALTVHESLS 1458
             +M  L R++EE   +  E  S
Sbjct: 1677 AQMKELWREVEETRTSREEIFS 1698



 Score =  134 bits (338), Expect = 5e-31
 Identities = 195/910 (21%), Positives = 376/910 (41%), Gaps = 109/910 (11%)

Query: 344  MVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAET 403
            MV  Q+   +   Q    ++ LQAA A  +D+G      ++S R++  +    +      
Sbjct: 1096 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1155

Query: 404  QEEMLQVLKEKMRLEGQLEAL---------SLEASQALKEKAELQAQLAALSTKLQAQVE 454
            +    +  K++  L  +LEAL         S  A Q L+ K E +      + + + ++ 
Sbjct: 1156 RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH 1215

Query: 455  CSHSSQQRQ------DSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVA 508
             +   + RQ        L+ +++  ++     E+    L+  +    A L+S     Q  
Sbjct: 1216 EAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEG 1275

Query: 509  EEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQV-------QLERTTLTSKL 561
            E++ +RL  +++++Q      +    +  +++   Q++L+ V       + +   L+ +L
Sbjct: 1276 EQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKEL 1335

Query: 562  KASQAEISSLQSVRQWYQQQLALAQEARVR-LQGEMAHIQVGQMTQAGLLEHLKLENVSL 620
             +++A++   Q + Q  + +  LA  +RVR ++ E A ++     +A   E    E  + 
Sbjct: 1336 SSTEAQLHDAQELLQ-EETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1394

Query: 621  SQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGE 680
              QL+E + R  +E G + A  +       + EA   ++ E KT   + L+R      G 
Sbjct: 1395 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE-KTETVDRLER------GR 1447

Query: 681  RERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSL 740
            R   Q + D+   LEQQ  Q+  TL ++ ++ + L      L ++      A++ RE++ 
Sbjct: 1448 RRLQQELDDATMDLEQQ-RQLVSTLEKKQRKFDQL------LAEEKAAVLRAVEERERA- 1499

Query: 741  DALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKE-------ELD 793
               +    E +AR   L       ++    L+ +   L A L+A  S K+       EL+
Sbjct: 1500 ---EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELE 1556

Query: 794  RGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK----------IKE 843
            R  R  E+   +    + +L +EL         L+    ALK Q ++           + 
Sbjct: 1557 RACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1616

Query: 844  QFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEK-------RT 896
            + L +++      RD   K + ++   A RK+L+ EL+EL+ ++      K       R 
Sbjct: 1617 RQLAKQLRDAEVERDEERKQRTLA--VAARKKLEGELEELKAQMASAGQGKEEAVKQLRK 1674

Query: 897  AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEAL 956
             +A++  L REV + R    ++    + ++K    +E  +  LQ   E++ A   A    
Sbjct: 1675 MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ---EELAASDRARRQA 1731

Query: 957  KKQIEELQQE------ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRL 1010
            ++  +E+  E      ++ AI E+K   R+L   L   ++E++ +    E    +L+ R 
Sbjct: 1732 QQDRDEMADEVANGNLSKAAILEEK---RQLEGRLGQLEEELEEEQSNSE----LLNDRY 1784

Query: 1011 QEALAAKEAADAELGQLRAQGGSSDSS-LALHERIQALEAELQAVSHSKTLLEKELQEVI 1069
            ++ L   E+   EL   R+    ++S    L  +IQ L   L           K     I
Sbjct: 1785 RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHK---MTI 1841

Query: 1070 ALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNA 1129
            A    +L ++ E   +LE E +E     K ++R E+  K++ L++E E            
Sbjct: 1842 AALESKLAQAEE---QLEQETRERILSGKLVRRAEKRLKEVVLQVEEE------------ 1886

Query: 1130 ALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVN 1189
              R     L   L K    + QL  Q    L+  EEE  + +   + LQ  LE   E   
Sbjct: 1887 --RRVADQLRDQLEKGNLRVKQLKRQ----LEEAEEEASRAQAGRRRLQRELEDVTESAE 1940

Query: 1190 SLKEQVAAAK 1199
            S+  +V   +
Sbjct: 1941 SMNREVTTLR 1950



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 50/206 (24%), Positives = 92/206 (44%), Gaps = 19/206 (9%)

Query: 365  LQAAAAEHQDQGQEVNGEVRS---RRDSICSSVSLESSAAETQEEMLQVLKEKMR-LEGQ 420
            L+    E Q   + +N   R    + +S+ + +S E S +   E   Q L+ +++ L G+
Sbjct: 1766 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGR 1825

Query: 421  LEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEV-----DTLKQ 475
            L        +    +A  +  +AAL +KL AQ E     + R+  LS ++       LK+
Sbjct: 1826 L------GEEDAGARARHKMTIAALESKL-AQAEEQLEQETRERILSGKLVRRAEKRLKE 1878

Query: 476  SCWDLE---RAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
                +E   R    L++ LE  N  +      L+ AEE+  R  A    +QR +     +
Sbjct: 1879 VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTES 1938

Query: 533  VHDLRQQMTALQSQLQQVQLERTTLT 558
               + +++T L+++L++  L  TT T
Sbjct: 1939 AESMNREVTTLRNRLRRGPLTFTTRT 1964


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.122    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,000,285
Number of Sequences: 37866
Number of extensions: 2670086
Number of successful extensions: 51276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 604
Number of HSP's successfully gapped in prelim test: 1625
Number of HSP's that attempted gapping in prelim test: 17868
Number of HSP's gapped (non-prelim): 13921
length of query: 1498
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1383
effective length of database: 13,892,928
effective search space: 19213919424
effective search space used: 19213919424
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.