Search of human proteins with 30023836

Search of human proteins with 30023836

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
         (505 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                       1041   0.0  
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   572   e-163
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   525   e-149
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   504   e-143
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   456   e-128
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   455   e-128
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   387   e-107
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   384   e-106
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   381   e-106
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   381   e-106
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   380   e-105
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   375   e-104
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   370   e-102
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   230   2e-60
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   177   3e-44
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   172   5e-43
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   171   1e-42
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   166   4e-41
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   157   3e-38
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   130   4e-30
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  116   4e-26
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   112   6e-25
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   112   8e-25
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   112   8e-25
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   112   8e-25
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   112   8e-25
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   105   1e-22
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   100   3e-21
gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide ...    95   1e-19
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ...    95   2e-19

>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score = 1041 bits (2693), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEF 60
           MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEF
Sbjct: 1   MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEF 60

Query: 61  YPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESW 120
           YPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESW
Sbjct: 61  YPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESW 120

Query: 121 VGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELF 180
           VGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELF
Sbjct: 121 VGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELF 180

Query: 181 QHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFS 240
           QHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFS
Sbjct: 181 QHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFS 240

Query: 241 SQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFS 300
           SQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFS
Sbjct: 241 SQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFS 300

Query: 301 EADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLS 360
           EADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLS
Sbjct: 301 EADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLS 360

Query: 361 QMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWED 420
           QMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWED
Sbjct: 361 QMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWED 420

Query: 421 PQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHS 480
           PQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHS
Sbjct: 421 PQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHS 480

Query: 481 RPPQPVRQVVLKSKNGIHVFAKKVC 505
           RPPQPVRQVVLKSKNGIHVFAKKVC
Sbjct: 481 RPPQPVRQVVLKSKNGIHVFAKKVC 505


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  572 bits (1473), Expect = e-163
 Identities = 271/506 (53%), Positives = 372/506 (73%), Gaps = 2/506 (0%)

Query: 1   MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEF 60
           ME SWL+   A PF L  + C++L L Q I+LY RR+ ++R L  FPAPP HWF GH++F
Sbjct: 1   MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 60

Query: 61  YPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESW 120
                 E   +++EKYP A P W+GPF  FF ++DPDYAK LL R DPKS    K     
Sbjct: 61  IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL 120

Query: 121 VGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIA-QNSRLEL 179
           +G+GL  LDG KW +HR+++ PGF+ +ILK +I +M+ SV+MML+KWE+  + Q++ +E+
Sbjct: 121 LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEV 180

Query: 180 FQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKF 239
           ++H++ M+LD IMKCAFS + + Q +ST D Y KA+F LSKI   R+ + L+H+D++FK 
Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

Query: 240 SSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRW-DFLDILLSAKSENTKD 298
           S QG  F K ++ L+Q+T+ +IQ+RK+SL+  +KQD T KR++ DFLDI+LSAK E+   
Sbjct: 241 SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS 300

Query: 299 FSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEH 358
           FS+ D+ +EV TF+ AGHDT +++ISWILYCLA  PEHQ+RCR+E+R +LGDGSSITW+ 
Sbjct: 301 FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ 360

Query: 359 LSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFW 418
           L +M YTTMCIKE  RL   V +ISR L KP+TFPDG +LPAGITV ++IW LHHNP  W
Sbjct: 361 LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW 420

Query: 419 EDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPD 478
           ++P+VF+PLRFS+ENS++ HPYA++PFSAG RNCIGQ FA+IE KV +AL LL F++ PD
Sbjct: 421 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD 480

Query: 479 HSRPPQPVRQVVLKSKNGIHVFAKKV 504
            +RP       +LK KNG+++  KK+
Sbjct: 481 PTRPLTFPNHFILKPKNGMYLHLKKL 506


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  525 bits (1352), Expect = e-149
 Identities = 256/488 (52%), Positives = 348/488 (71%), Gaps = 4/488 (0%)

Query: 19  LLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGH-KEFYPVKEFEVYHKLMEKYP 77
           LL + LLL + ++LY  R+W+++AL  FP PP+HW +GH +E    +E +   K +E +P
Sbjct: 24  LLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFP 83

Query: 78  CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHR 137
            A P W+    +   ++DPDY K++L R DPKS  S++ L  W+G GL+ L+G  W +HR
Sbjct: 84  SACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHR 143

Query: 138 QIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFS 197
           +++ P F+  ILK ++ +M++SVR+ML+KWEE + Q+S LE+FQHVSLMTLD+IMKCAFS
Sbjct: 144 RMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFS 203

Query: 198 HQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 257
           HQGSIQ+D    SY++A+ +L+ +   R+ N  H ND ++  +S G+   +  Q  HQ T
Sbjct: 204 HQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHT 263

Query: 258 EKVIQDRKESL-KDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316
           ++VIQ RK  L K+   +   +KR  DFLDILL AK EN    S+ DL+AEV TFMF GH
Sbjct: 264 DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGH 323

Query: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLY 376
           DTT+S ISWILY LA +P+HQ+RCR+EI  LLGDG+SITW HL QMPYTTMCIKE LRLY
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLY 383

Query: 377 APVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEK 436
            PV  I R L  P+TFPDGRSLP GI V ++I+ LHHNP  W +P+VF+P RF+  +++ 
Sbjct: 384 PPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ- 442

Query: 437 IHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNG 496
            H +AF+PFS G RNCIG+ FA+ E KVA ALTLLRF+L PD +R P P+ ++VLKSKNG
Sbjct: 443 -HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNG 501

Query: 497 IHVFAKKV 504
           IH+  +++
Sbjct: 502 IHLRLRRL 509


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  504 bits (1297), Expect = e-143
 Identities = 252/488 (51%), Positives = 344/488 (70%), Gaps = 4/488 (0%)

Query: 19  LLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGH-KEFYPVKEFEVYHKLMEKYP 77
           LL + LLL +  +LY  R+W+++AL  FP PP+HW +GH +EF   +E +   + ++ +P
Sbjct: 24  LLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFP 83

Query: 78  CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHR 137
            A P W+    +   ++DPDY K++L R DPKS  S+K L   +G GL+ L+G  W +HR
Sbjct: 84  SACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHR 143

Query: 138 QIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFS 197
           +++ P F+  ILK ++ +M++SVR+ML+KWEE + Q+S LE+FQHVSLMTLD+IMK AFS
Sbjct: 144 RMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFS 203

Query: 198 HQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 257
           HQGSIQ+D    SY++A+ +L+ +    M N  H ND ++  +S G+   +  Q  HQ T
Sbjct: 204 HQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT 263

Query: 258 EKVIQDRKESL-KDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316
           ++VIQ RK  L K+   +   +KR  DFLDILL AK EN    S+ DL+AEV TFMF GH
Sbjct: 264 DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGH 323

Query: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLY 376
           DTT+S ISWILY LA +P+HQ+RCR+EI  LLGDG+SITW HL QMPYTTMCIKE LRLY
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLY 383

Query: 377 APVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEK 436
            PV  I R L  P+TFPDGRSLP GI V ++I+ LHHNP  W + +VF+P RF+  +++ 
Sbjct: 384 PPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ- 442

Query: 437 IHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNG 496
            H +AF+PFS G RNCIG+ FA+ + KVA ALTLLRF+L PD +R P P+ ++VLKSKNG
Sbjct: 443 -HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNG 501

Query: 497 IHVFAKKV 504
           IH+  +++
Sbjct: 502 IHLRLRRL 509


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  456 bits (1173), Expect = e-128
 Identities = 228/504 (45%), Positives = 321/504 (63%), Gaps = 3/504 (0%)

Query: 1   MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHK-E 59
           M PS+L    +   L    L + L   ++I L  RR+ + +A+  FP PP HW +GH  E
Sbjct: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60

Query: 60  FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILES 119
                  +       ++P A PLW G F  F ++++PDYAK +  R DPK+   +     
Sbjct: 61  IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120

Query: 120 WVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLEL 179
           W+GRGL+ L+G KW +HR+++ PGF+  +LK ++ + +ES R+ML+KWEE   +    ++
Sbjct: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180

Query: 180 FQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKF 239
           F  V  M L+++MKC F  +G   L     SY  AV +L+ +  QR+ +F +HND ++  
Sbjct: 181 FCDVGHMALNTLMKCTFG-RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 239

Query: 240 SSQGQIFSKFNQELHQFTEKVIQDRKESLKD-KLKQDTTQKRRWDFLDILLSAKSENTKD 298
           +  G+ F +  Q  H  T++VI++RK +L+D K+++    +R  DFLDILL A+ E+   
Sbjct: 240 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 299

Query: 299 FSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEH 358
            S+ADL+AEV TFMF GHDTT+S ISW LYC+A YPEHQ RCR+E+RE+LGD     W+ 
Sbjct: 300 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 359

Query: 359 LSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFW 418
           L +M Y TMCIKE  RLY PV  + R L KP+TF DGRSLPAG  + ++I+ALH N   W
Sbjct: 360 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 419

Query: 419 EDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPD 478
            DP+VF+ LRFS EN+ K HP+AF+PFSAG RNCIGQ FA+ E KV  A+ LLRF+ + D
Sbjct: 420 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 479

Query: 479 HSRPPQPVRQVVLKSKNGIHVFAK 502
            SR P  + Q+VL+SKNG H+  K
Sbjct: 480 PSRLPIKMPQLVLRSKNGFHLHLK 503


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  455 bits (1171), Expect = e-128
 Identities = 229/505 (45%), Positives = 323/505 (63%), Gaps = 4/505 (0%)

Query: 1   MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHK-E 59
           M PS+L    +   L    L + L   ++I L  RR+ + +A+  FP PP HW +GH  E
Sbjct: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60

Query: 60  FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILES 119
                  +       ++P A PLW G F  F ++++PDYAK +  R DPK+   +     
Sbjct: 61  IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120

Query: 120 WVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLEL 179
           W+GRGL+ L+G KW +HR+++ PGF+  +LK ++ + +ES R+ML+KWEE   +    ++
Sbjct: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180

Query: 180 FQHVSLMTLDSIMKCAFSHQGSIQLDSTLDS-YLKAVFNLSKISNQRMNNFLHHNDLVFK 238
           F  V  M L+++MKC F  +G   L  + DS Y  AV +L+ +  QR+ +F +HND ++ 
Sbjct: 181 FCDVGHMALNTLMKCTFG-RGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYW 239

Query: 239 FSSQGQIFSKFNQELHQFTEKVIQDRKESLKD-KLKQDTTQKRRWDFLDILLSAKSENTK 297
            +  G+ F +  Q  H  T++VI++RK +L+D K+++    +R  DFLDILL A+ E+  
Sbjct: 240 LTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDI 299

Query: 298 DFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWE 357
             S+ADL+AEV TFMF GHDTT+S ISW LYC+A YPEHQ RCR+E+RE+LGD     W+
Sbjct: 300 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD 359

Query: 358 HLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYF 417
            L +M Y TMCIKE  RLY PV  + R L KP+TF DGRSLPAG  + ++I+ALH N   
Sbjct: 360 DLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAV 419

Query: 418 WEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP 477
           W DP+VF+ LRFS EN+ K HP+AF+PFSAG RNCIGQ FA+ E KV  A+ LLRF+ + 
Sbjct: 420 WPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSL 479

Query: 478 DHSRPPQPVRQVVLKSKNGIHVFAK 502
           D SR P  + Q+VL+SKNG H+  K
Sbjct: 480 DPSRLPIKMPQLVLRSKNGFHLHLK 504


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  387 bits (995), Expect = e-107
 Identities = 209/509 (41%), Positives = 312/509 (61%), Gaps = 18/509 (3%)

Query: 4   SWLQ--ELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPA-HWFYGHKEF 60
           SWL    + A P+LLL+L+  S LL  V+          R L  FP PP  +WF+GH+  
Sbjct: 7   SWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGM 66

Query: 61  Y-PVKE-FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD---PKSAVSHK 115
             P +E   V  +L+  YP    +W+GP +   S+  PD  + ++       PK    + 
Sbjct: 67  VNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYS 126

Query: 116 ILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNS 175
            LE W+G GL+   G KW +HR+++ P F+ +ILK ++ + +ESV +M  KW+   ++ S
Sbjct: 127 FLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGS 186

Query: 176 R-LELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHND 234
             L++F+H+SLMTLDS+ KC FS     Q   +   Y+ A+  LS + ++R +  L H D
Sbjct: 187 ACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS--EYIAAILELSALVSKRHHEILLHID 244

Query: 235 LVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK----DKLKQDTTQKRRWDFLDILLS 290
            ++  +  GQ F +  + +H FT+ VIQ+R+ +L     D   Q   + +  DF+D+LL 
Sbjct: 245 FLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLL 304

Query: 291 AKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD 350
           +K E+ K  S+ D++AE  TFMF GHDTT+S +SW+LY LAK+PE+Q+RCR E++ELL D
Sbjct: 305 SKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKD 364

Query: 351 GS--SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408
                I W+ L+ +P+ TMC+KE LRL+ PV  ISR + + I  PDGR +P GI   I++
Sbjct: 365 REPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISV 424

Query: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468
           +  HHNP  W DP+V++P RF  EN ++  P AFIPFSAG RNCIGQ FA+ E KV +AL
Sbjct: 425 FGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLAL 484

Query: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKNGI 497
           TLLRF++ PDH+ P +   ++VL+++ G+
Sbjct: 485 TLLRFRVLPDHTEPRRK-PELVLRAEGGL 512


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  384 bits (986), Expect = e-106
 Identities = 204/509 (40%), Positives = 312/509 (61%), Gaps = 18/509 (3%)

Query: 4   SWL--QELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAP-PAHWFYGHKEF 60
           SWL  + + A P+LLL+++  S LL +++          R L  FP P   +WF GH   
Sbjct: 7   SWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGL 66

Query: 61  Y-PVKE-FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP---KSAVSHK 115
             P +E   V  +L+  YP     W+GP T   ++  PD  + ++   D    K  V +K
Sbjct: 67  VTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYK 126

Query: 116 ILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNS 175
            L+ W+G GL+   G KW+ HR+++ P F+ +ILK +I + S+S  +M  KW+    + S
Sbjct: 127 TLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS 186

Query: 176 R-LELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHND 234
             L++F+H+SLMTLDS+ KC FS   + Q   +   Y+ A+  LS +  +R N F  + D
Sbjct: 187 TCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPS--EYITAIMELSALVVKRNNQFFRYKD 244

Query: 235 LVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK----DKLKQDTTQKRRWDFLDILLS 290
            ++  +  G+ F +  + +H FT+ VIQ+R+ +L     D   Q   + +  DF+D+LL 
Sbjct: 245 FLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLL 304

Query: 291 AKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD 350
           ++ +N K+ S+ D++AE  TFMF GHDTT+S +SW+LY LA++PE+Q+RCR E++ELL D
Sbjct: 305 SEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364

Query: 351 GS--SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408
                I W+ L+Q+P+ TMC+KE LRL+ P+   +R   + +  PD R +P G    INI
Sbjct: 365 REPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINI 424

Query: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468
           +A+HHNP  W DP+V++P RF  EN++K  P AFIPFSAG RNCIGQ FA+ E KV +AL
Sbjct: 425 FAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLAL 484

Query: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKNGI 497
           TLLRF++ PDH R P+   ++VL++++G+
Sbjct: 485 TLLRFRILPDH-REPRRTPEIVLRAEDGL 512


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  381 bits (978), Expect = e-106
 Identities = 204/509 (40%), Positives = 311/509 (61%), Gaps = 18/509 (3%)

Query: 4   SWLQ--ELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPA-HWFYGHKEF 60
           SWL    + A P+LLL+L+  S LL +V+          R L  FP PP  +WF+GH+  
Sbjct: 7   SWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGL 66

Query: 61  Y-PVKE-FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD---PKSAVSHK 115
             P +E  +   +L+  YP    LW+GP      +  PD  + +        PK  + + 
Sbjct: 67  VTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYG 126

Query: 116 ILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNS 175
            L+ W+G GL+   G KW +HR+++ P F+ +ILK ++ + ++SV +M +KW+   ++ S
Sbjct: 127 FLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGS 186

Query: 176 -RLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHND 234
            RL++F+H+SLMTLDS+ KC FS + + Q   +   Y+ A+  LS    +R    L H D
Sbjct: 187 ARLDMFEHISLMTLDSLQKCVFSFESNCQEKPS--EYIAAILELSAFVEKRNQQILLHTD 244

Query: 235 LVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK----DKLKQDTTQKRRWDFLDILLS 290
            ++  +  GQ F +    +H FT+ VIQ+R+ +L     D   ++  + +  DF+D+LL 
Sbjct: 245 FLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLL 304

Query: 291 AKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD 350
           +K E+ K+ S+ D++AE  TFMF GHDTT+S +SW+LY LAK+PE+Q++CR E++ELL D
Sbjct: 305 SKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKD 364

Query: 351 GS--SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408
                I W+ L+Q+P+ TMCIKE LRL+ PV  ISR   +    PDGR +P GI   INI
Sbjct: 365 REPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINI 424

Query: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468
             +H+NP  W DP+V++P RF +EN ++  P AFIPFSAG RNCIGQ FA+ E KV +AL
Sbjct: 425 IGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484

Query: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKNGI 497
           TLL F++ P H+ P +   +++L+++ G+
Sbjct: 485 TLLHFRILPTHTEPRRK-PELILRAEGGL 512


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  381 bits (978), Expect = e-106
 Identities = 204/509 (40%), Positives = 311/509 (61%), Gaps = 18/509 (3%)

Query: 4   SWLQ--ELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPA-HWFYGHKEF 60
           SWL    + A P+LLL+L+  S LL +V+          R L  FP PP  +WF+GH+  
Sbjct: 7   SWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGL 66

Query: 61  Y-PVKE-FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD---PKSAVSHK 115
             P +E  +   +L+  YP    LW+GP      +  PD  + +        PK  + + 
Sbjct: 67  VTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYG 126

Query: 116 ILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNS 175
            L+ W+G GL+   G KW +HR+++ P F+ +ILK ++ + ++SV +M +KW+   ++ S
Sbjct: 127 FLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGS 186

Query: 176 -RLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHND 234
            RL++F+H+SLMTLDS+ KC FS + + Q   +   Y+ A+  LS    +R    L H D
Sbjct: 187 ARLDMFEHISLMTLDSLQKCVFSFESNCQEKPS--EYIAAILELSAFVEKRNQQILLHTD 244

Query: 235 LVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK----DKLKQDTTQKRRWDFLDILLS 290
            ++  +  GQ F +    +H FT+ VIQ+R+ +L     D   ++  + +  DF+D+LL 
Sbjct: 245 FLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLL 304

Query: 291 AKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD 350
           +K E+ K+ S+ D++AE  TFMF GHDTT+S +SW+LY LAK+PE+Q++CR E++ELL D
Sbjct: 305 SKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKD 364

Query: 351 GS--SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408
                I W+ L+Q+P+ TMCIKE LRL+ PV  ISR   +    PDGR +P GI   INI
Sbjct: 365 REPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINI 424

Query: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468
             +H+NP  W DP+V++P RF +EN ++  P AFIPFSAG RNCIGQ FA+ E KV +AL
Sbjct: 425 IGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484

Query: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKNGI 497
           TLL F++ P H+ P +   +++L+++ G+
Sbjct: 485 TLLHFRILPTHTEPRRK-PELILRAEGGL 512


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  380 bits (976), Expect = e-105
 Identities = 200/506 (39%), Positives = 308/506 (60%), Gaps = 18/506 (3%)

Query: 6   LQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPA-HWFYGHKEFY-PV 63
           L+ +   P+LLL+L+  S LL +++          R L  FP PP  +WF+GH     P 
Sbjct: 11  LRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPT 70

Query: 64  KE-FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD---PKSAVSHKILES 119
           +E  +   ++   Y     +W+GP   F  +  PD  + +        PK  +  + L+ 
Sbjct: 71  EEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKP 130

Query: 120 WVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQ--NSRL 177
           W+G G++   G KW +HR+++ P F+ +ILK +IT+ ++S  +ML+KW+ H+A   +SRL
Sbjct: 131 WLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQ-HLASEGSSRL 189

Query: 178 ELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVF 237
           ++F+H+SLMTLDS+ KC FS     Q       Y+  +  LS +  +R  + L H D ++
Sbjct: 190 DMFEHISLMTLDSLQKCIFSFDSHCQ--ERPSEYIATILELSALVEKRSQHILQHMDFLY 247

Query: 238 KFSSQGQIFSKFNQELHQFTEKVIQDRKESLK----DKLKQDTTQKRRWDFLDILLSAKS 293
             S  G+ F +  + +H FT+ VI++R+ +L     D   +D  + +  DF+D+LL +K 
Sbjct: 248 YLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD 307

Query: 294 ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS- 352
           E+ K  S+ D++AE  TFMF GHDTT+S +SW+LY LA++PE+Q+RCR E++ELL D   
Sbjct: 308 EDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDP 367

Query: 353 -SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWAL 411
             I W+ L+Q+P+ TMC+KE LRL+ P   ISR   + I  PDGR +P GIT  I+I  +
Sbjct: 368 KEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGV 427

Query: 412 HHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLL 471
           HHNP  W DP+V++P RF  ENS+   P AFIPFSAG RNCIGQ FA+ E KV +AL LL
Sbjct: 428 HHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLL 487

Query: 472 RFKLAPDHSRPPQPVRQVVLKSKNGI 497
            F+  PDH+ P + + +++++++ G+
Sbjct: 488 HFRFLPDHTEPRRKL-ELIMRAEGGL 512


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  375 bits (964), Expect = e-104
 Identities = 196/496 (39%), Positives = 304/496 (61%), Gaps = 16/496 (3%)

Query: 15  LLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPA-HWFYGHKEFYPVKE--FEVYHK 71
           LL +L  +  LL + +RL +      R L  FP PP  +W  GH   Y   E   +   K
Sbjct: 28  LLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKK 87

Query: 72  LMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD---PKSAVSHKILESWVGRGLVTL 128
           +++     + +W+GP      +  PDY K LL       PK  + +  L+ W+G GL+  
Sbjct: 88  VLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLS 147

Query: 129 DGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSR--LELFQHVSLM 186
            G KW +HR+++ P F+  ILK ++ + ++S  +M  KW  H+A+ S   L++F+H+SLM
Sbjct: 148 KGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWR-HLAEGSAVSLDMFEHISLM 206

Query: 187 TLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIF 246
           TLDS+ KC FS+  + Q    +  Y+ A+  LS +S +R     H+ D ++  S+ G+ F
Sbjct: 207 TLDSLQKCVFSYNSNCQ--EKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRF 264

Query: 247 SKFNQELHQFTEKVIQDRKESLKDKLKQ---DTTQKRRWDFLDILLSAKSENTKDFSEAD 303
            +    +H FT +VIQ+R+ +L+ +  +      Q +  DF+D+LL A+ E+ K+ S+ D
Sbjct: 265 RQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDED 324

Query: 304 LQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG--DGSSITWEHLSQ 361
           ++AE  TFMF GHDTTSS ISW+L+ LAKYPE+Q++CR+EI+E++   +   + W+ L+Q
Sbjct: 325 IRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQ 384

Query: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421
           +P+TTMCIKE LR Y PV  +SR   + I  PDGR +P GI   ++I+  HHNP  W D 
Sbjct: 385 LPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDS 444

Query: 422 QVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSR 481
           +V+NP RF  +N ++  P A++PFSAG RNCIGQ FA+ E +V VALTLLRF+L+ D +R
Sbjct: 445 KVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTR 504

Query: 482 PPQPVRQVVLKSKNGI 497
             +   +++L+++NG+
Sbjct: 505 KVRRKPELILRTENGL 520


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  370 bits (950), Expect = e-102
 Identities = 202/505 (40%), Positives = 301/505 (59%), Gaps = 16/505 (3%)

Query: 6   LQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPA-HWFYGHKEFYPVK 64
           L  + A P+LLL+L+  S LL +++            L  FP PP  +WF GH       
Sbjct: 11  LWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSS 70

Query: 65  EFEVYH--KLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD---PKSAVSHKILES 119
           E  + +   L   +      WVGP+     +  P Y K +L       PK  V +  L+ 
Sbjct: 71  EEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKP 130

Query: 120 WVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNS-RLE 178
           W+G GL+   G KW +HR+++ P F+ +ILK ++ + +ESV +M  KW+   ++ S RL+
Sbjct: 131 WLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLD 190

Query: 179 LFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFK 238
           +F+H+SLMTLDS+ KC FS     Q   +   Y+ A+  LS +  +R    L + D ++ 
Sbjct: 191 MFEHISLMTLDSLQKCVFSFDSHCQEKPS--EYIAAILELSALVTKRHQQILLYIDFLYY 248

Query: 239 FSSQGQIFSKFNQELHQFTEKVIQDRKESLK----DKLKQDTTQKRRWDFLDILLSAKSE 294
            +  GQ F +  + +H FT+ VIQ+R+ +L     D   Q   + +  DF+D+LL +K E
Sbjct: 249 LTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDE 308

Query: 295 NTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-- 352
           + K  S+ D++AE  TFMF GHDTT+S +SW+LY LAK+PE+Q+RCR E++ELL D    
Sbjct: 309 DGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPK 368

Query: 353 SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALH 412
            I W+ L+Q+P+ TMCIKE LRL+ PV  +SR   + I  PDGR +P GI   I+++  H
Sbjct: 369 EIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTH 428

Query: 413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLR 472
           HNP  W DP+V++P RF  +N ++  P AFIPFSAG RNCIGQ FA+ E KV + LTLLR
Sbjct: 429 HNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLR 488

Query: 473 FKLAPDHSRPPQPVRQVVLKSKNGI 497
           F++ PDH+ P +   ++VL+++ G+
Sbjct: 489 FRVLPDHTEPRRK-PELVLRAEGGL 512


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  230 bits (587), Expect = 2e-60
 Identities = 157/495 (31%), Positives = 252/495 (50%), Gaps = 21/495 (4%)

Query: 24  LLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLME-----KYPC 78
           L L Q +  Y R+   +R +       A+   GH         E + +++E     ++  
Sbjct: 31  LSLLQRVASYARKWQQMRPIPTVAR--AYPLVGHALLMKPDGREFFQQIIEYTEEYRHMP 88

Query: 79  AVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138
            + LWVGP  M    +  +   IL   +    +  +K LE W+G GL+T  G+KW+  R+
Sbjct: 89  LLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRK 148

Query: 139 IVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSH 198
           ++ P F+ +IL+ F+ +M+E   +++ K E+HI Q +    F +++L  LD I + A   
Sbjct: 149 MLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA-FNCFFYITLCALDIICETAMGK 207

Query: 199 QGSIQLDSTLDS-YLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 257
             +I   S  DS Y++AV+ +S++  +R+       DL +    +G    K  Q LH FT
Sbjct: 208 --NIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFT 265

Query: 258 EKVIQDRKESLK-------DKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKT 310
             VI +R   +        D      ++ +R  FLD+LLS   +     S  D++ EV T
Sbjct: 266 NSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDT 325

Query: 311 FMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCI 369
           FMF GHDTT++AI+W LY L   PE Q++   E+ ++ G      T E L ++ Y    I
Sbjct: 326 FMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVI 385

Query: 370 KECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRF 429
           KE LRL+  V   +R + +       R L     V I  +ALH +P ++ +P+ F P RF
Sbjct: 386 KETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIP-YALHRDPRYFPNPEEFQPERF 444

Query: 430 SRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVR-Q 488
             EN++  HPYA++PFSAG RNCIGQ FA++E K  ++  L  F +  +  R    +  Q
Sbjct: 445 FPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQ 504

Query: 489 VVLKSKNGIHVFAKK 503
           ++L+  NGI +  K+
Sbjct: 505 LILRPSNGIWIKLKR 519


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  177 bits (448), Expect = 3e-44
 Identities = 144/500 (28%), Positives = 240/500 (48%), Gaps = 45/500 (9%)

Query: 18  ILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYP 77
           +L+  SL+L  +   +  +  + + L + P P    F G   FY    +    +  EKY 
Sbjct: 13  VLVATSLVLLYIYGTHSHK--LFKKLGI-PGPTPLPFLGTILFYLRGLWNFDRECNEKYG 69

Query: 78  CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTLDGSKWKK 135
               L+ G   M   + DPD  K +L ++      +   L    ++   L   +  +WK+
Sbjct: 70  EMWGLYEGQQPMLV-IMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKR 128

Query: 136 HRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCA 195
            R ++ P F     K  + ++S+   M++    +    +  + L       T+D I    
Sbjct: 129 IRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTL 188

Query: 196 FSHQGSIQLDST---LDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFN-- 250
           F     + LDS     D +LK +  L K+    ++ FL    L+  F     +F   N  
Sbjct: 189 FG----VNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLL---LISLFPFLTPVFEALNIG 239

Query: 251 ---QELHQFTEKVIQDRKES-LKDKLKQDTTQKRRWDFLDILL----SAKSENTKDFSEA 302
              +++  F +  I+  KES LKDK      QK R DF   ++    S ++++ K  S+ 
Sbjct: 240 LFPKDVTHFLKNSIERMKESRLKDK------QKHRVDFFQQMIDSQNSKETKSHKALSDL 293

Query: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQM 362
           +L A+    +FA +DTTS+ + +I+Y LA +P+ QQ+ ++EI  +L + + +T++ L QM
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQM 353

Query: 363 PYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQ 422
            Y  M + E LRL+  V  ++R+  K I   +G  +P G+ V + I+ALHH+P +W +P+
Sbjct: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412

Query: 423 VFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP----- 477
            F P RFS++N + I  Y +IPF AG RNCIG  FA+   K+AV   L  F   P     
Sbjct: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ 472

Query: 478 -----DHSRPPQPVRQVVLK 492
                D+    QP + +VLK
Sbjct: 473 IPLKLDNLPILQPEKPIVLK 492


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  172 bits (437), Expect = 5e-43
 Identities = 144/501 (28%), Positives = 240/501 (47%), Gaps = 46/501 (9%)

Query: 18  ILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYP 77
           +L+  SL+L  +   +  +  + + L + P P    F G   FY    +    +  EKY 
Sbjct: 13  VLVATSLVLLYIYGTHSHK--LFKKLGI-PGPTPLPFLGTILFYLRGLWNFDRECNEKYG 69

Query: 78  CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTLDGSKWKK 135
               L+ G   M   + DPD  K +L ++      +   L    ++   L   +  +WK+
Sbjct: 70  EMWGLYEGQQPMLV-IMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKR 128

Query: 136 HRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCA 195
            R ++ P F     K  + ++S+   M++    +    +  + L       T+D I    
Sbjct: 129 IRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTL 188

Query: 196 FSHQGSIQLDST---LDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFN-- 250
           F     + LDS     D +LK +  L K+    ++ FL    L+  F     +F   N  
Sbjct: 189 FG----VNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLL---LISLFPFLTPVFEALNIG 239

Query: 251 ---QELHQFTEKVIQDRKES-LKDKLKQDTTQKRRWDFLDILL----SAKSENTKDFSEA 302
              +++  F +  I+  KES LKDK      QK R DF   ++    S ++++ K  S+ 
Sbjct: 240 LFPKDVTHFLKNSIERMKESRLKDK------QKHRVDFFQQMIDSQNSKETKSHKALSDL 293

Query: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQM 362
           +L A+    +FA +DTTS+ + +I+Y LA +P+ QQ+ ++EI  +L + + +T++ L QM
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQM 353

Query: 363 PYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQ 422
            Y  M + E LRL+  V  ++R+  K I   +G  +P G+ V + I+ALHH+P +W +P+
Sbjct: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412

Query: 423 VFNP-LRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP---- 477
            F P  RFS++N + I  Y +IPF AG RNCIG  FA+   K+AV   L  F   P    
Sbjct: 413 KFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKET 472

Query: 478 ------DHSRPPQPVRQVVLK 492
                 D+    QP + +VLK
Sbjct: 473 QIPLKLDNLPILQPEKPIVLK 493


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  171 bits (433), Expect = 1e-42
 Identities = 126/476 (26%), Positives = 231/476 (48%), Gaps = 37/476 (7%)

Query: 18  ILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGH-----KEF--YPVKEFEVYH 70
           +LL +SL+L   + LY  R   +      P P    F G+     K +  + ++ ++ Y 
Sbjct: 13  LLLAVSLIL---LYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYR 69

Query: 71  KLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTL 128
           K+   Y C  P+         ++ DPD  K +L ++      + +      ++   +   
Sbjct: 70  KVWGIYDCQQPM--------LAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIA 121

Query: 129 DGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTL 188
           +  +WK+ R ++ P F    LK  + ++++   +++            + L       ++
Sbjct: 122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSM 181

Query: 189 DSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSS---QGQI 245
           D I   +F     + +DS  +     V N  K+      +    +  VF F +   +   
Sbjct: 182 DVITSTSFG----VSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALN 237

Query: 246 FSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAK----SENTKDFSE 301
            + F +++  F  K ++  KE    +LK+  TQK R DFL +++ ++    SE  K  S+
Sbjct: 238 ITVFPRKVISFLTKSVKQIKEG---RLKE--TQKHRVDFLQLMIDSQNSKDSETHKALSD 292

Query: 302 ADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQ 361
            +L A+   F+FAG++TTSS +S+I+Y LA +P+ QQ+ + EI  +L + +  T++ + Q
Sbjct: 293 LELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQ 352

Query: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421
           + Y  M + E LRL+   + + R+  K +   +G  +P G+ V I  + LHH+P +W +P
Sbjct: 353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEP 411

Query: 422 QVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP 477
           + F P RFS++N + I PY + PF +G RNCIG  FA++  K+A+   L  F   P
Sbjct: 412 EKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  166 bits (421), Expect = 4e-41
 Identities = 116/420 (27%), Positives = 208/420 (49%), Gaps = 29/420 (6%)

Query: 92  SVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTLDGSKWKKHRQIVKPGFNISIL 149
           ++ DPD  K +L ++      + +      ++   +   +  +WK+ R ++ P F    L
Sbjct: 83  AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL 142

Query: 150 KIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLD 209
           K  + ++++   +++            + L       ++D I   +F     + +DS  +
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG----VNIDSLNN 198

Query: 210 SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSS---QGQIFSKFNQELHQFTEKVIQDRKE 266
                V N  K+      +    +  VF F     +      F +E+  F  K ++  KE
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKE 258

Query: 267 SLKDKLKQDTTQKRRWDFLDILL----SAKSENTKDFSEADLQAEVKTFMFAGHDTTSSA 322
           S     + + TQK R DFL +++    S ++E+ K  S+ +L A+   F+FAG++TTSS 
Sbjct: 259 S-----RLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313

Query: 323 ISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNI 382
           +S+I+Y LA +P+ QQ+ ++EI  +L + +  T++ + QM Y  M + E LRL+   + +
Sbjct: 314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373

Query: 383 SRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAF 442
            R+  K +   +G  +P G+ V I  +ALH +P +W +P+ F P RFS++N + I PY +
Sbjct: 374 ERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIY 432

Query: 443 IPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP-DHSRPP---------QPVRQVVLK 492
            PF +G RNCIG  FA++  K+A+   L  F   P   ++ P         QP + VVLK
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLK 492


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  157 bits (396), Expect = 3e-38
 Identities = 119/447 (26%), Positives = 212/447 (47%), Gaps = 40/447 (8%)

Query: 66  FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGR 123
           ++ Y K+   Y   +P+         ++ DPD  + +L ++      + + L    ++  
Sbjct: 65  YKKYGKMWGTYEGQLPV--------LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS 116

Query: 124 GLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHV 183
            +   +  +WK+ R ++ P F    LK    ++++   +++        +   + L    
Sbjct: 117 AISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIF 176

Query: 184 SLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSS-- 241
              ++D I   +F     + +DS  +     V +  K       + L  + ++F F +  
Sbjct: 177 GAYSMDVITGTSFG----VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPV 232

Query: 242 -QGQIFSKFNQELHQFTEKVIQDRKES-LKDKLKQDTTQKRRWDFLDILL----SAKSEN 295
            +    S F ++   F  K +   K+S L DK      QK R DFL +++    S ++E+
Sbjct: 233 FEALNVSLFPKDTINFLSKSVNRMKKSRLNDK------QKHRLDFLQLMIDSQNSKETES 286

Query: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355
            K  S+ +L A+   F+FAG++TTSS +S+ LY LA +P+ QQ+ + EI  +L + +  T
Sbjct: 287 HKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT 346

Query: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415
           ++ + QM Y  M + E LRL+   + + R   K +   +G  +P G  V I  +ALHH+P
Sbjct: 347 YDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDP 405

Query: 416 YFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKL 475
            +W +P+ F P RFS++  + I PY + PF  G RNCIG  FA++  K+A+   L  F  
Sbjct: 406 KYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464

Query: 476 AP----------DHSRPPQPVRQVVLK 492
            P          D     QP + +VLK
Sbjct: 465 KPCKETQIPLKLDTQGLLQPEKPIVLK 491


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  130 bits (326), Expect = 4e-30
 Identities = 115/426 (26%), Positives = 202/426 (47%), Gaps = 35/426 (8%)

Query: 18  ILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYP 77
           +L+  SL+L  +   +  +  + + L + P P    F G   FY    +    +  EKY 
Sbjct: 13  VLVATSLVLLYIYGTHSHK--LFKKLGI-PGPTPLPFLGTILFYLRGLWNFDRECNEKYG 69

Query: 78  CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTLDGSKWKK 135
               L+ G   M   + DPD  K +L ++      +   L    ++   L   +  +WK+
Sbjct: 70  EMWGLYEGQQPMLV-IMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKR 128

Query: 136 HRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCA 195
            R ++ P F     K  + ++S+   M++    +    +  + L       T+D I    
Sbjct: 129 IRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTL 188

Query: 196 FSHQGSIQLDST---LDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFN-- 250
           F     + LDS     D +LK +  L K+    ++ FL    L+  F     +F   N  
Sbjct: 189 FG----VNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLL---LISLFPFLTPVFEALNIG 239

Query: 251 ---QELHQFTEKVIQDRKES-LKDKLKQDTTQKRRWDFLDILL----SAKSENTKDFSEA 302
              +++  F +  I+  KES LKDK      QK R DF   ++    S ++++ K  S+ 
Sbjct: 240 LFPKDVTHFLKNSIERMKESRLKDK------QKHRVDFFQQMIDSQNSKETKSHKALSDL 293

Query: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQM 362
           +L A+    +FA +DTTS+ + +I+Y LA +P+ QQ+ ++EI  +L + + +T++ L QM
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQM 353

Query: 363 PYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQ 422
            Y  M + E LRL+  V  ++R+  K I   +G  +P G+ V + I+ALHH+P +W +P+
Sbjct: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412

Query: 423 VFNPLR 428
            F P R
Sbjct: 413 KFCPER 418


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  116 bits (291), Expect = 4e-26
 Identities = 108/430 (25%), Positives = 188/430 (43%), Gaps = 44/430 (10%)

Query: 58  KEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKIL 117
           K++ PV    V+HK                T           K L+  +  K +  ++ L
Sbjct: 69  KKYGPVVRVNVFHK----------------TSVIVTSPESVKKFLMSTKYNKDSKMYRAL 112

Query: 118 -----ESWVGRGLVT-LDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHI 171
                E   G+GLV+  +  +W K R+++   F+ S L   +   +E    ++   E   
Sbjct: 113 QTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKA 172

Query: 172 AQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDST--LDSYLKAVFNLSKISNQRMNNF 229
              + + +   ++   +D + K AF  + S+ L +   L   +K +      S   +  F
Sbjct: 173 DGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKF 232

Query: 230 LHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILL 289
           L       +   +   F      L Q     +Q R+E+LK        ++   D L  +L
Sbjct: 233 LPGKRKQLREVRESIRF------LRQVGRDWVQRRREALK------RGEEVPADILTQIL 280

Query: 290 SAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG 349
            A+ E  +D  +  L     TF  AGH+T+++ +++ +  L++ PE   R + E+ E++G
Sbjct: 281 KAE-EGAQD--DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG 337

Query: 350 DGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIW 409
               + +E L ++ Y +  +KE LRLY P     RLL++  T  DG  +P    +  + +
Sbjct: 338 SKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTY 396

Query: 410 ALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVA-- 467
            +     ++EDP  FNP RF     +    + + PFS G R+CIGQ FA +E KV +A  
Sbjct: 397 VMGRMDTYFEDPLTFNPDRFGPGAPKP--RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454

Query: 468 LTLLRFKLAP 477
           L  L F+L P
Sbjct: 455 LQRLEFRLVP 464


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  112 bits (281), Expect = 6e-25
 Identities = 100/388 (25%), Positives = 169/388 (43%), Gaps = 35/388 (9%)

Query: 124 GLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQ-- 181
           GL+   G  WK+ R+     F ++ L+ F  +  +S+   + +  +H+ +  + E  Q  
Sbjct: 125 GLIMSSGQAWKEQRR-----FTLTALRNF-GLGKKSLEERIQEEAQHLTEAIKEENGQPF 178

Query: 182 --HVSLMTLDSIMKCAFSHQGSIQL-DSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFK 238
             H  +    S + C+ +     +  DS     LK +  ++ +   +     +    + K
Sbjct: 179 DPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMK 238

Query: 239 F--SSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENT 296
           F       +FS + ++L  F   +I        DK ++D       DF+D  L   S++T
Sbjct: 239 FLPGPHQTLFSNW-KKLKLFVSHMI--------DKHRKDWNPAETRDFIDAYLKEMSKHT 289

Query: 297 ----KDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS 352
                 F E +L        FAG +TTS+ + W L  +A YPE Q++ + EI  ++G G 
Sbjct: 290 GNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQ 349

Query: 353 SITWEHLSQMPYTTMCIKECLRLYAPV-VNISRLLDKPITFPDGRSLPAGITVFINIWAL 411
             +      MPYT   I E  R+   + +N+ R +    T   G  LP G  +  N+ AL
Sbjct: 350 QPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA-GYHLPKGTMILTNLTAL 408

Query: 412 HHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLL 471
           H +P  W  P  FNP  F  EN +     AF+PFS G R C+G+  A  E  +     + 
Sbjct: 409 HRDPTEWATPDTFNPDHF-LENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQ 467

Query: 472 RFKLAPDHSRPPQPVRQVVLKSKNGIHV 499
           +F   P ++       ++ LK + GI +
Sbjct: 468 KFTFRPPNN------EKLSLKFRMGITI 489


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  112 bits (280), Expect = 8e-25
 Identities = 113/532 (21%), Positives = 223/532 (41%), Gaps = 67/532 (12%)

Query: 17  LILLCMSLLLFQVIRLYQR----RRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKL 72
           ++ + +S+ L  +++ Y      R   +   H  P+P    F G+  F+    +E   +L
Sbjct: 16  MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSP----FIGNLTFFRQGFWESQMEL 71

Query: 73  MEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPK--SAVSHKILESWVGRGLVTLDG 130
            + Y      ++G   MF  + +PD  K +L        + ++  +    V   ++ L  
Sbjct: 72  RKLYGPLCGYYLGR-RMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD 130

Query: 131 SKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDS 190
            +W++ R  +   F+   L   + ++S++  ++L   + +       ++ +     T D 
Sbjct: 131 KRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDV 190

Query: 191 IMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIF---- 246
           +   AF         + +DS+        K   +     +    LV   S    +     
Sbjct: 191 VASVAFG--------TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLAR 242

Query: 247 ---SKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAK----------- 292
              +K   EL+ F  K+I++   +L+D   Q   ++RR DFL ++L A+           
Sbjct: 243 ILPNKNRDELNGFFNKLIRN-VIALRD---QQAAEERRRDFLQMVLDARHSASPMGVQDF 298

Query: 293 ----------------------SENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCL 330
                                 S   +  +  ++  +   F+ AG++  ++ +S+  Y L
Sbjct: 299 DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLL 358

Query: 331 AKYPEHQQRCRDEIRELLGDGSSITWEHLSQ-MPYTTMCIKECLRLYAPVVNISRLLDKP 389
           A  P+ Q++   E+        +  +  L + +PY  M I E LR+Y P    +R   + 
Sbjct: 359 ATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQD 418

Query: 390 ITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGL 449
                G+ +PAG  + + + ALHH+P  W  P+ FNP RF+ E  ++  P+ ++PF AG 
Sbjct: 419 CEVL-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGP 477

Query: 450 RNCIGQHFAIIECKVAV--ALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHV 499
           R+C+G    ++E K+ +   L   RF+  P+   P Q   +  L  KNG+++
Sbjct: 478 RSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYI 529


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  112 bits (280), Expect = 8e-25
 Identities = 113/532 (21%), Positives = 223/532 (41%), Gaps = 67/532 (12%)

Query: 17  LILLCMSLLLFQVIRLYQR----RRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKL 72
           ++ + +S+ L  +++ Y      R   +   H  P+P    F G+  F+    +E   +L
Sbjct: 16  MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSP----FIGNLTFFRQGFWESQMEL 71

Query: 73  MEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPK--SAVSHKILESWVGRGLVTLDG 130
            + Y      ++G   MF  + +PD  K +L        + ++  +    V   ++ L  
Sbjct: 72  RKLYGPLCGYYLGR-RMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD 130

Query: 131 SKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDS 190
            +W++ R  +   F+   L   + ++S++  ++L   + +       ++ +     T D 
Sbjct: 131 KRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDV 190

Query: 191 IMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIF---- 246
           +   AF         + +DS+        K   +     +    LV   S    +     
Sbjct: 191 VASVAFG--------TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLAR 242

Query: 247 ---SKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAK----------- 292
              +K   EL+ F  K+I++   +L+D   Q   ++RR DFL ++L A+           
Sbjct: 243 ILPNKNRDELNGFFNKLIRN-VIALRD---QQAAEERRRDFLQMVLDARHSASPMGVQDF 298

Query: 293 ----------------------SENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCL 330
                                 S   +  +  ++  +   F+ AG++  ++ +S+  Y L
Sbjct: 299 DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLL 358

Query: 331 AKYPEHQQRCRDEIRELLGDGSSITWEHLSQ-MPYTTMCIKECLRLYAPVVNISRLLDKP 389
           A  P+ Q++   E+        +  +  L + +PY  M I E LR+Y P    +R   + 
Sbjct: 359 ATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQD 418

Query: 390 ITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGL 449
                G+ +PAG  + + + ALHH+P  W  P+ FNP RF+ E  ++  P+ ++PF AG 
Sbjct: 419 CEVL-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGP 477

Query: 450 RNCIGQHFAIIECKVAV--ALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHV 499
           R+C+G    ++E K+ +   L   RF+  P+   P Q   +  L  KNG+++
Sbjct: 478 RSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYI 529


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  112 bits (280), Expect = 8e-25
 Identities = 69/242 (28%), Positives = 116/242 (47%), Gaps = 14/242 (5%)

Query: 248 KFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAE 307
           +  +++  F +K+I+D +ESL  +  QD        F+D+ L    E  K+ S +    E
Sbjct: 289 QIEKDITSFLKKIIKDHQESLDRENPQD--------FIDMYLLHMEEERKNNSNSSFDEE 340

Query: 308 -----VKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQM 362
                +     AG DTT++++ W L  ++  P+ Q++  +EI  ++G   + +    +QM
Sbjct: 341 YLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQM 400

Query: 363 PYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQ 422
           PYT   I E  RL   V      +    T   G ++P G  +  N+W++H +P  WE P+
Sbjct: 401 PYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPE 460

Query: 423 VFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLA-PDHSR 481
            F P RF  +  + I    FIPF  G R C+G+  A +E  +     +  F  A P+ S+
Sbjct: 461 DFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSK 520

Query: 482 PP 483
            P
Sbjct: 521 KP 522


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  112 bits (280), Expect = 8e-25
 Identities = 73/252 (28%), Positives = 120/252 (47%), Gaps = 13/252 (5%)

Query: 236 VFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSEN 295
           +  F    Q+F      ++ F  ++I+    + K +L Q         +LD +   K++ 
Sbjct: 237 ILPFGKHQQLFRNA-AVVYDFLSRLIEKASVNRKPQLPQHFVDA----YLDEMDQGKNDP 291

Query: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355
           +  FS+ +L   V   + AG +TT++ + W +  +A YP  Q + + EI  ++G     +
Sbjct: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351

Query: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPD----GRSLPAGITVFINIWAL 411
           W+   +MPYT   + E LR      NI  L     T  D    G S+P G TV  N++++
Sbjct: 352 WDDKCKMPYTEAVLHEVLRF----CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407

Query: 412 HHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLL 471
           H +  +W DP+VF+P RF   +       A +PFS G R+C+G+H A +E  +     L 
Sbjct: 408 HFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467

Query: 472 RFKLAPDHSRPP 483
           RF L   H   P
Sbjct: 468 RFHLHFPHELVP 479


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  105 bits (262), Expect = 1e-22
 Identities = 88/367 (23%), Positives = 172/367 (46%), Gaps = 24/367 (6%)

Query: 122 GRGLVTLDGSKWKKHR-----QIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSR 176
           G GL+ L+G  W++ R     +++KPG    ++K+    ++E +   + + +E   +   
Sbjct: 144 GYGLLILEGEDWQRVRSAFQKKLMKPG---EVMKLD-NKINEVLADFMGRIDELCDERGH 199

Query: 177 LE-LFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDL 235
           +E L+  ++  + +SI    +  +  +   +  D  +  +  +  +    M+ F     +
Sbjct: 200 VEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTM----MSTF--GRMM 253

Query: 236 VFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSEN 295
           V        + +K  Q+     + + +  K  + ++L++ + Q       D L     +N
Sbjct: 254 VTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSA----DFLCDIYHQN 309

Query: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355
               S+ +L A V     A  +TT++++ WILY L++ P+ QQ+   EI+ +L +     
Sbjct: 310 R--LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPR 367

Query: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415
            E L  MPY   C+KE +RL   V   +R LDK     +  +LP G  + +N   L  + 
Sbjct: 368 AEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGTVLMLNTQVLGSSE 426

Query: 416 YFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKL 475
             +ED   F P R+ +E  EKI+P+A +PF  G R CIG+  A ++  +A+   + ++ +
Sbjct: 427 DNFEDSSQFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 485

Query: 476 APDHSRP 482
               + P
Sbjct: 486 QATDNEP 492


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  100 bits (249), Expect = 3e-21
 Identities = 67/195 (34%), Positives = 102/195 (52%), Gaps = 5/195 (2%)

Query: 308 VKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSI--TWEHLSQMPYT 365
           V   + AG DT S+ +SW LY L+++PE Q     EI   L  GSS   +   LSQ+P  
Sbjct: 311 VTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLL 370

Query: 366 TMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFN 425
              +KE LRLY  V   SR+ DK I   D   +P    V +  +A   +P  + +P  F 
Sbjct: 371 KAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRDPAQFPEPNSFR 429

Query: 426 PLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPD-HSRPPQ 484
           P R+  E     HP+A +PF  G R+C+G+  A +E ++A+A  L  F++ P+  + P +
Sbjct: 430 PARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVR 488

Query: 485 PVRQVVLKSKNGIHV 499
           P  + VL  +  I++
Sbjct: 489 PKTRTVLVPERSINL 503


>gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 71/222 (31%), Positives = 121/222 (54%), Gaps = 12/222 (5%)

Query: 265 KESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAIS 324
           ++++++KL Q T  K   D LD+L+ +  E+ K+ +  +L+      +FA + TT+SA +
Sbjct: 248 EKAIREKL-QCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASAST 306

Query: 325 WILYCLAKYPEHQQRCRDEIRE--LLGDG-----SSITWEHLSQMPYTTMCIKECLRLYA 377
            ++  L K+P   ++ RDE+R   +L  G      ++  + LS + Y    IKE +RL+ 
Sbjct: 307 SLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFT 366

Query: 378 PVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSE-K 436
           P+    R + +     DG  +P G +V  +I   H     ++D  VF+P RFS+  SE K
Sbjct: 367 PISGGYRTVLQTFEL-DGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDK 425

Query: 437 IHPYAFIPFSAGLRNCIGQHFAIIECKV-AVAL-TLLRFKLA 476
              + ++PF  G+R C+G+H A +  KV AV L +  RF+LA
Sbjct: 426 DGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELA 467


>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
           precursor [Homo sapiens]
          Length = 531

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 69/262 (26%), Positives = 125/262 (47%), Gaps = 17/262 (6%)

Query: 253 LHQFTEKVIQDRKESLKDKLKQ---DTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVK 309
           +  F +K+I ++ E ++ +L+    D  Q     +L  LL++        S  +    + 
Sbjct: 278 IFSFGKKLIDEKLEDMEAQLQAAGPDGIQVS--GYLHFLLASGQ-----LSPREAMGSLP 330

Query: 310 TFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCI 369
             + AG DTTS+ ++W LY L+K PE Q+   +E+  ++  G     +  + MP     +
Sbjct: 331 ELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVL 390

Query: 370 KECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRF 429
           KE LRLY  V   SR+++K I   DG   P         + +  +P  + +P+ F P R+
Sbjct: 391 KETLRLYPVVPTNSRIIEKEIEV-DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRW 449

Query: 430 SRENSEKI----HPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFK--LAPDHSRPP 483
            R +        HP+  +PF  G+R C+G+  A +E ++ +A  + ++K  LAP+     
Sbjct: 450 LRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELK 509

Query: 484 QPVRQVVLKSKNGIHVFAKKVC 505
              R V++ +K     F ++ C
Sbjct: 510 SVARIVLVPNKKVGLQFLQRQC 531


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.138    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,547,073
Number of Sequences: 37866
Number of extensions: 846997
Number of successful extensions: 2903
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2645
Number of HSP's gapped (non-prelim): 121
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.