Search of human proteins with 122937267

Search of human proteins with 122937267

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
         (1489 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]                  3116   0.0  
gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]      622   e-177
gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]                    417   e-116
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   172   2e-42
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   169   1e-41
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   169   1e-41
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   168   4e-41
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   167   7e-41
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   167   9e-41
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   165   3e-40
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   165   3e-40
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   165   3e-40
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   158   3e-38
gi|62420886 discoidin domain receptor family, member 2 precursor...   158   4e-38
gi|62420884 discoidin domain receptor family, member 2 precursor...   158   4e-38
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    158   4e-38
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [...   156   2e-37
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [...   156   2e-37
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [...   156   2e-37
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [...   156   2e-37
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs...   155   2e-37
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs...   155   2e-37
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            155   4e-37
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           155   4e-37
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]     152   2e-36
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   150   9e-36
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec...   150   9e-36
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso...   150   9e-36
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]         147   7e-35
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]         147   7e-35

>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
          Length = 1489

 Score = 3116 bits (8078), Expect = 0.0
 Identities = 1489/1489 (100%), Positives = 1489/1489 (100%)

Query: 1    MRQVLWLCNVCVTARETRHHLHLPAILDKMPAPGALILLAAVSASGCLASPAHPDGFALG 60
            MRQVLWLCNVCVTARETRHHLHLPAILDKMPAPGALILLAAVSASGCLASPAHPDGFALG
Sbjct: 1    MRQVLWLCNVCVTARETRHHLHLPAILDKMPAPGALILLAAVSASGCLASPAHPDGFALG 60

Query: 61   RAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCSGEYTPPAEET 120
            RAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCSGEYTPPAEET
Sbjct: 61   RAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCSGEYTPPAEET 120

Query: 121  SSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGE 180
            SSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGE
Sbjct: 121  SSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGE 180

Query: 181  IFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIME 240
            IFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIME
Sbjct: 181  IFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIME 240

Query: 241  FCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRN 300
            FCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRN
Sbjct: 241  FCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRN 300

Query: 301  CLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRES 360
            CLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRES
Sbjct: 301  CLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRES 360

Query: 361  NIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSC 420
            NIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSC
Sbjct: 361  NIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSC 420

Query: 421  WRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPF 480
            WRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPF
Sbjct: 421  WRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPF 480

Query: 481  PLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPS 540
            PLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPS
Sbjct: 481  PLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPS 540

Query: 541  NPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQ 600
            NPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQ
Sbjct: 541  NPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQ 600

Query: 601  APSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGE 660
            APSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGE
Sbjct: 601  APSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGE 660

Query: 661  RGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAG 720
            RGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAG
Sbjct: 661  RGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAG 720

Query: 721  WGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPP 780
            WGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPP
Sbjct: 721  WGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPP 780

Query: 781  APPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGG 840
            APPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGG
Sbjct: 781  APPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGG 840

Query: 841  AAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVT 900
            AAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVT
Sbjct: 841  AAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVT 900

Query: 901  RNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLEN 960
            RNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLEN
Sbjct: 901  RNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLEN 960

Query: 961  GDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVN 1020
            GDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVN
Sbjct: 961  GDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVN 1020

Query: 1021 GGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETS 1080
            GGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETS
Sbjct: 1021 GGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETS 1080

Query: 1081 LERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGS 1140
            LERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGS
Sbjct: 1081 LERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGS 1140

Query: 1141 GGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPE 1200
            GGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPE
Sbjct: 1141 GGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPE 1200

Query: 1201 VAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKARLSRL 1260
            VAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKARLSRL
Sbjct: 1201 VAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKARLSRL 1260

Query: 1261 SLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEA 1320
            SLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEA
Sbjct: 1261 SLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEA 1320

Query: 1321 AAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSELERKRKMV 1380
            AAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSELERKRKMV
Sbjct: 1321 AAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSELERKRKMV 1380

Query: 1381 SFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGG 1440
            SFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGG
Sbjct: 1381 SFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGG 1440

Query: 1441 SFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN 1489
            SFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN
Sbjct: 1441 SFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN 1489


>gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]
          Length = 1374

 Score =  622 bits (1603), Expect = e-177
 Identities = 527/1514 (34%), Positives = 688/1514 (45%), Gaps = 270/1514 (17%)

Query: 45   SGCLASPAHPDGFALGRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENP 104
            S   +S   PDG  L         AVV +S SGL A I L+L CLCCK+G +GFKEFEN 
Sbjct: 9    SFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENA 68

Query: 105  EGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHS-DMTTPLGLSRQHLS 163
            EG++ + +    +  T++ Q+ PDVY+LPL EVSLPM A QP  S  +     + R  L 
Sbjct: 69   EGDEYAADLAQGSPATAA-QNGPDVYVLPLTEVSLPM-AKQPGRSVQLLKSTDVGRHSLL 126

Query: 164  YLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVL 223
            YL+EIG GWFGKV LGE+ S  + AQVVVKEL+ASA   EQ +F+ E QPYR+L+H N+L
Sbjct: 127  YLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLL 186

Query: 224  QCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGL 283
            QCL  C E  P+LL+MEFC LGDLK YLR+ R  E ++P     D RTLQRM  E+A G+
Sbjct: 187  QCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP-----DPRTLQRMACEVACGV 241

Query: 284  AHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPEL 343
             HLH +N+VHSDLALRNCLLT+DLTV+IGDYGLAH  Y+EDY++T ++LW+PLRW APEL
Sbjct: 242  LHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPEL 301

Query: 344  LGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARP 403
            + E+H   +VVDQ++  N+WSLGVT+WELFE G QPY   SD++VLA+ VR+Q +KL +P
Sbjct: 302  VDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKP 361

Query: 404  RLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPP---------PPP 454
            +L+L  +D WY+++Q CW  P QRP+A ++ L L+YL ++                 P  
Sbjct: 362  QLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGG 421

Query: 455  PRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPG----ADPDDVLTVTESSRGLNLECLW 510
               GP P    P          +S FPLL+ F G    AD DDVLTVTE+SRGLN E  W
Sbjct: 422  GGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKW 481

Query: 511  EKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIR 570
            E     AGRG  A    PA+  P   A          + P V+PV+SA SPS+ SEY+IR
Sbjct: 482  E-----AGRGAEA---FPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIR 533

Query: 571  LEE-----------HGSPPEPLFPNDWDPLDPGVPAPQAPQ-------APSEVPQLVSET 612
            LEE            G  P P    D D    G  A             P +VP    + 
Sbjct: 534  LEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDH 593

Query: 613  W------ASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPW 666
            +        PL P+  P P    ++G   L+    E    G   A  PA      GT+P 
Sbjct: 594  YPRRSLARDPLCPSRSPSP----SAGPLSLAEGGAEDADWG-VAAFCPAFFEDPLGTSPL 648

Query: 667  VEEEEEEEEGSSP----GEDSSSLGGG--PSRRGPLPCPLCSREGACSCLPLERGDAVAG 720
                     G+ P    GED     G    ++RG     + +   + S  P E  D V+ 
Sbjct: 649  ------GSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNVSANNNSGSRCP-ESWDPVSA 701

Query: 721  WGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMG--AAAPQYPGRGP 778
             GGH A GCP P +               P A P    P   +PL+G  AA+ Q PG   
Sbjct: 702  -GGH-AEGCPSPKQ--------------TPRASPEPGYPG--EPLLGLQAASAQEPG--- 740

Query: 779  PPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPG 838
               P  P         PA     PS   +  SG   P  +P     E E    P    P 
Sbjct: 741  -CCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP-KLATEAEGTTGPRLPLPS 798

Query: 839  GGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLRED 898
              +  +EG P P      PD  AP   PD  P P  G         +VS  +L  +L   
Sbjct: 799  VPSPSQEGAPLPSEEASAPD--APDALPD-SPTPATGG--------EVSAIKLASAL--- 844

Query: 899  VTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAP-------SLSLP 951
                     G+++       +       E   G+  D +  G   + P       SL   
Sbjct: 845  --------NGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQ 896

Query: 952  VNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENG-ELRS 1010
            V     L++ D     I   A++ G         +V       P   + +AL++G +  +
Sbjct: 897  VGTPDSLDSLD-----IPSSASDGG--------YEVFSPSATGPSGGQPRALDSGYDTEN 943

Query: 1011 PEAGEKVL--VNGGLTPPKSEDKVSENGGLRFPRNTERPPETG-PWRAPGPWEKTPESWG 1067
             E+ E VL     G  P    +  SE  G          PET       G  EK P    
Sbjct: 944  YESPEFVLKEAQEGCEPQAFAELASEGEG--------PGPETRLSTSLSGLNEKNP---- 991

Query: 1068 PAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGA 1127
                  + A  + LE     ++    + GG+ APGP    P  G  +P  +         
Sbjct: 992  ----YRDSAYFSDLEAEAEATSGPEKKCGGDRAPGPELGLPSTG--QPSEQ--------V 1037

Query: 1128 PRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPP---LPPPPE 1184
               PG               +G A G GPG  V      ++ + P+P   P   +P PPE
Sbjct: 1038 CLRPGV--------------SGEAQGSGPGE-VLPPLLQLEGSSPEPSTCPSGLVPEPPE 1082

Query: 1185 AQ-PRRLEPAPPRARPEV-----APEGEPGAPDSRAGGDTALSGDGDPPKPERK--GPEM 1236
             Q P ++ P P  +  +       P    G      G    LSG    P P+++  GP  
Sbjct: 1083 PQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSG----PAPQKRMGGPGT 1138

Query: 1237 PRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGG 1296
            PR                   + L LALP                         G  A  
Sbjct: 1139 PR-------------------APLRLALP-------------------------GLPAAL 1154

Query: 1297 AGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLR 1356
             G P   EED ED DE +EE        +   P       A  VPVVV  A++ +AR LR
Sbjct: 1155 EGRPEEEEEDSEDSDESDEE----LRCYSVQEPSEDSEEEAPAVPVVV--AESQSARNLR 1208

Query: 1357 GLLKSPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPS--- 1413
             LLK P    E    +LERK+K VSF  DVTVYLFDQE+PT EL    P   ++ P+   
Sbjct: 1209 SLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLR 1268

Query: 1414 TPPAPPTPPHPATPGDGFPSNDSG-FGGSFEWAEDFPL----------LPPPGP------ 1456
              P  P+ P+     DG P+  +   GG F W +DFPL          L P  P      
Sbjct: 1269 GSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPAAPT 1328

Query: 1457 --PLCFSRFSVSPA 1468
              P  FSRF+VSPA
Sbjct: 1329 PTPAPFSRFTVSPA 1342


>gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]
          Length = 1503

 Score =  417 bits (1073), Expect = e-116
 Identities = 251/610 (41%), Positives = 352/610 (57%), Gaps = 61/610 (10%)

Query: 30  MPAPGAL------ILLAAVSASGCLASPAHPDGFALGRAPLAPPYA---VVLISCSGLLA 80
           MP P AL      +LL  + A    A+P    G   G AP A   +   V+L  CS L+ 
Sbjct: 1   MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTG--AGEAPPAAEVSSSFVILCVCS-LII 57

Query: 81  FIFLLLTCL-CCKRGDVGFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSL 139
            I L+  C+ CCK  ++ FKEFE+   ++   ++TPPAE+T S QS  +V+ L +  +SL
Sbjct: 58  LIVLIANCVSCCKDPEIDFKEFEDNFDDEI--DFTPPAEDTPSVQSPAEVFTLSVPNISL 115

Query: 140 PMPAP-QPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRAS 198
           P P+  QPS   + + +  +R  L+Y+QEIG+GWFGKV+LGEI++  + A+V+VKEL+AS
Sbjct: 116 PAPSQFQPSVEGLKSQV--ARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKAS 173

Query: 199 AGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPE 258
           A P EQ  F+   +PY  LQHPN+LQC+G CVE +P+LL+ EFC LGDLK YLR+++   
Sbjct: 174 ANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQ--- 230

Query: 259 GLSPELPPRDLRT--LQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGL 316
               E    D +T  LQRM  E+A GLA +H  +++HSDLALRNC LTSDL V++GDYG+
Sbjct: 231 ----EHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGI 286

Query: 317 AHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFG 376
             S YKEDY  T ++   PLRW APEL+       +  DQ++ SNIWSLGVTLWELF+  
Sbjct: 287 GFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNA 346

Query: 377 AQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQ 436
           AQPY +LS+ +VL  V+R++  KL +P+L+ PY+D WY++LQ CW  P +RP+A D+   
Sbjct: 347 AQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRL 406

Query: 437 LTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFP----GADPD 492
           LTYL      R         D    W     ++  R  + ++ FP+LD F     G + +
Sbjct: 407 LTYL------RLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREME 460

Query: 493 DVLTVTESSRGLNLECLWEKARRG----AGRGG------------GAPAWQPASAPPAPH 536
           +VLTVTE+S+GL+ E +WE A+        RG                 ++ + + P P 
Sbjct: 461 EVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPG 520

Query: 537 ANPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSP------PEPLFPNDWDPLD 590
               +     L  P V+PV  A + SV S+YYI+LEE          P  L   D D  +
Sbjct: 521 KQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMD--N 578

Query: 591 PGVPAPQAPQ 600
           P    P+  Q
Sbjct: 579 PERTGPELSQ 588



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 141/538 (26%), Positives = 190/538 (35%), Gaps = 70/538 (13%)

Query: 997  RREEKALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAP 1056
            RR EK LE  E  +    +      GL    S D  S++  L    +   P        P
Sbjct: 938  RRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETP 997

Query: 1057 GPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKN-GTLEP 1115
               E          ++G   P+  L     P+         E+    L PAP+     EP
Sbjct: 998  DSLESVDVHEALLDSLGSHTPQ-KLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEP 1056

Query: 1116 GTERRAPETGGAPRAPGAGRLDLGSGGRAP-VGTGTAPGGGPGSGVDAKAGWVDNTRPQP 1174
             T      +G  P  P     D G G R   V   T   G  GS  D+ A + DN     
Sbjct: 1057 ATTGDGGHSGLPPN-PVIVISDAGDGHRGTEVTPETFTAGSQGSYRDS-AYFSDND--SE 1112

Query: 1175 PPPPLPPPPEAQPRRLEPAPPRARPE-VAPEGEPGAPDS--------------------- 1212
            P       P   P  L     +  PE V PE  P A DS                     
Sbjct: 1113 PEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCLEARKSQPDESCLSALHNSS 1172

Query: 1213 ----RAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIK-------------- 1254
                RA  + A +G      P       P   L+     G+  + +              
Sbjct: 1173 DLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNT 1232

Query: 1255 -ARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDED 1313
               L+  + AL     +   GP  + P  EG   G  G             EDG D DE+
Sbjct: 1233 NELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLG-----VSGMLDLSEDGMDADEE 1287

Query: 1314 EEE----DEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLK-SPRGADEP 1368
            +E     DE+  A    +           PVP+++S+ D    R LR LLK +   A +P
Sbjct: 1288 DENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDG---RHLRSLLKPTAANAPDP 1344

Query: 1369 EDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPG 1428
               + ++++K V+F  DVTVYLFDQETPT EL          D S P      P+ +   
Sbjct: 1345 LPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCI 1404

Query: 1429 DGFPSNDSGFGGSFEWAEDFPLLPPPGPPLCFSR-FSVSPALET-----PGPPARAPD 1480
            +   S D   GG FEW +DF   P P      S   S  P+L+T     P PPAR+ +
Sbjct: 1405 NSESSTDEE-GGGFEWDDDFS--PDPFMSKTTSNLLSSKPSLQTSKYFSPPPPARSTE 1459



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 34/95 (35%), Positives = 36/95 (37%), Gaps = 15/95 (15%)

Query: 781  APPPPPPPPRAPADPAASPDPPSAVA-SPGSGLSS---PGPKPGDSGYETETPFSPEGAF 836
            AP P   P     D   S D   A+  S GS       P  KP DSGYETE   SPE   
Sbjct: 985  APFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTL 1044

Query: 837  ---PGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDP 868
               P G A  E        P    D G    PP+P
Sbjct: 1045 HPAPEGTADSE--------PATTGDGGHSGLPPNP 1071


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score =  172 bits (436), Expect = 2e-42
 Identities = 131/411 (31%), Positives = 200/411 (48%), Gaps = 47/411 (11%)

Query: 60  GRAPLAPPYAVVLISCSG--LLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCS------- 110
           GR  L+    VV+ S  G  LL  +FLL      K G  G     + + +  S       
Sbjct: 427 GREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISN 486

Query: 111 GEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPL--------GLSRQHL 162
           G  TP     SSS+  PD  I+ + ++ +      P +  +T            + R ++
Sbjct: 487 GSNTP-----SSSEGGPDAVIIGMTKIPV---IENPQYFGITNSQLKPDTFVQHIKRHNI 538

Query: 163 SYLQEIGSGWFGKVILGEIFSDYTPAQ----VVVKELRASAGPLEQRKFISEAQPYRSLQ 218
              +E+G G FGKV L E ++   P Q    V VK L+  A    ++ F  EA+   +LQ
Sbjct: 539 VLKRELGEGAFGKVFLAECYN-LCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQ 596

Query: 219 HPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPE-LPPRDLRTLQRMGL 277
           H ++++  G+CVE  P +++ E+ + GDL ++LRA  P   L  E  PP +L   Q + +
Sbjct: 597 HEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHI 656

Query: 278 --EIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIP 335
             +IA G+ +L S ++VH DLA RNCL+  +L V+IGD+G++   Y  DYY       +P
Sbjct: 657 AQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 716

Query: 336 LRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQ 395
           +RW  PE       + M    + ES++WSLGV LWE+F +G QP+  LS+ EV+  +   
Sbjct: 717 IRWMPPE-------SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT-- 767

Query: 396 QHVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDLQLQLTYLLSERP 445
           Q   L RPR         Y+++  CW R P  R +   +   L  L    P
Sbjct: 768 QGRVLQRPR---TCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASP 815


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  169 bits (429), Expect = 1e-41
 Identities = 101/277 (36%), Positives = 158/277 (57%), Gaps = 16/277 (5%)

Query: 157  LSRQHLSYLQEIGSGWFGKVILG---EIFSDYTPAQVVVKELRASAGPLEQRKFISEAQP 213
            +SR+ ++ L+E+G G FG V  G   +I       +V VK +  SA   E+ +F++EA  
Sbjct: 1006 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 1065

Query: 214  YRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQ 273
             +     +V++ LG+  +  P L++ME    GDLK YLR+ RP    +P  PP  L+ + 
Sbjct: 1066 MKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMI 1125

Query: 274  RMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLW 333
            +M  EIA G+A+L++  +VH DLA RNC++  D TV+IGD+G+    Y+ DYY    +  
Sbjct: 1126 QMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGL 1185

Query: 334  IPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVV 393
            +P+RW APE L +  G F     +  S++WS GV LWE+     QPY+ LS+E+VL FV+
Sbjct: 1186 LPVRWMAPESLKD--GVF-----TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM 1238

Query: 394  RQQHVKLARPRLKLPYADYWYDILQSCWR-PPAQRPS 429
               +  L +P       +   D+++ CW+  P  RP+
Sbjct: 1239 DGGY--LDQPD---NCPERVTDLMRMCWQFNPKMRPT 1270


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  169 bits (429), Expect = 1e-41
 Identities = 101/277 (36%), Positives = 158/277 (57%), Gaps = 16/277 (5%)

Query: 157  LSRQHLSYLQEIGSGWFGKVILG---EIFSDYTPAQVVVKELRASAGPLEQRKFISEAQP 213
            +SR+ ++ L+E+G G FG V  G   +I       +V VK +  SA   E+ +F++EA  
Sbjct: 1018 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 1077

Query: 214  YRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQ 273
             +     +V++ LG+  +  P L++ME    GDLK YLR+ RP    +P  PP  L+ + 
Sbjct: 1078 MKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMI 1137

Query: 274  RMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLW 333
            +M  EIA G+A+L++  +VH DLA RNC++  D TV+IGD+G+    Y+ DYY    +  
Sbjct: 1138 QMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGL 1197

Query: 334  IPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVV 393
            +P+RW APE L +  G F     +  S++WS GV LWE+     QPY+ LS+E+VL FV+
Sbjct: 1198 LPVRWMAPESLKD--GVF-----TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM 1250

Query: 394  RQQHVKLARPRLKLPYADYWYDILQSCWR-PPAQRPS 429
               +  L +P       +   D+++ CW+  P  RP+
Sbjct: 1251 DGGY--LDQPD---NCPERVTDLMRMCWQFNPKMRPT 1282


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
           a precursor [Homo sapiens]
          Length = 838

 Score =  168 bits (425), Expect = 4e-41
 Identities = 115/352 (32%), Positives = 179/352 (50%), Gaps = 38/352 (10%)

Query: 110 SGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPL--------GLSRQH 161
           +G  TP     SSS+  PD  I+ + ++ +      P +  +T            + R +
Sbjct: 502 NGSNTP-----SSSEGGPDAVIIGMTKIPV---IENPQYFGITNSQLKPDTFVQHIKRHN 553

Query: 162 LSYLQEIGSGWFGKVILGEIFSDYTPAQ----VVVKELRASAGPLEQRKFISEAQPYRSL 217
           +   +E+G G FGKV L E ++   P Q    V VK L+  A    ++ F  EA+   +L
Sbjct: 554 IVLKRELGEGAFGKVFLAECYN-LCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNL 611

Query: 218 QHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPE-LPPRDLRTLQRMG 276
           QH ++++  G+CVE  P +++ E+ + GDL ++LRA  P   L  E  PP +L   Q + 
Sbjct: 612 QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH 671

Query: 277 L--EIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWI 334
           +  +IA G+ +L S ++VH DLA RNCL+  +L V+IGD+G++   Y  DYY       +
Sbjct: 672 IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML 731

Query: 335 PLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVR 394
           P+RW  PE       + M    + ES++WSLGV LWE+F +G QP+  LS+ EV+  +  
Sbjct: 732 PIRWMPPE-------SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT- 783

Query: 395 QQHVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDLQLQLTYLLSERP 445
            Q   L RPR         Y+++  CW R P  R +   +   L  L    P
Sbjct: 784 -QGRVLQRPR---TCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASP 831


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  167 bits (423), Expect = 7e-41
 Identities = 98/277 (35%), Positives = 158/277 (57%), Gaps = 16/277 (5%)

Query: 157  LSRQHLSYLQEIGSGWFGKVILGE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQP 213
            ++R+ ++  +E+G G FG V  G    +  D    +V +K +  +A   E+ +F++EA  
Sbjct: 994  VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASV 1053

Query: 214  YRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQ 273
             +     +V++ LG+  +  P L+IME    GDLK YLR+ RP    +P L P  L  + 
Sbjct: 1054 MKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI 1113

Query: 274  RMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLW 333
            +M  EIA G+A+L+++ +VH DLA RNC++  D TV+IGD+G+    Y+ DYY    +  
Sbjct: 1114 QMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGL 1173

Query: 334  IPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVV 393
            +P+RW +PE L +  G F     +  S++WS GV LWE+     QPY+ LS+E+VL FV+
Sbjct: 1174 LPVRWMSPESLKD--GVF-----TTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVM 1226

Query: 394  RQQHVKLARPRLKLPYADYWYDILQSCWR-PPAQRPS 429
              +   L +P       D  +++++ CW+  P  RPS
Sbjct: 1227 --EGGLLDKPD---NCPDMLFELMRMCWQYNPKMRPS 1258


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  167 bits (422), Expect = 9e-41
 Identities = 108/292 (36%), Positives = 164/292 (56%), Gaps = 24/292 (8%)

Query: 147  SHSDMTTP--LGLSRQHLSYLQEIGSGWFGKVILG-----EIFSDYTPAQVVVKELRASA 199
            S SDM  P    + R+ +S ++E+G G FG V  G     E   + TP  V +K +   A
Sbjct: 962  SASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTP--VALKTVNELA 1019

Query: 200  GPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEG 259
             P E  +F+ EA   ++ +  +V++ LG+  +  P L+IME    GDLK +LR+ RP   
Sbjct: 1020 SPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE 1079

Query: 260  LSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHS 319
             +P LP   L  + +M  EIA G+A+L ++ +VH DLA RNC+++ D TV+IGD+G+   
Sbjct: 1080 NNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRD 1139

Query: 320  NYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQP 379
             Y+ DYY    +  +P+RW APE L +  G F     +  S++WS GV LWE+     QP
Sbjct: 1140 VYETDYYRKGGKGLLPVRWMAPESLKD--GIF-----TTHSDVWSFGVVLWEIVTLAEQP 1192

Query: 380  YRHLSDEEVLAFVVRQQHV-KLARPRLKLPYADYWYDILQSCWRP-PAQRPS 429
            Y+ LS+E+VL FV+    + +L    L+L       +++  CW+P P  RPS
Sbjct: 1193 YQGLSNEQVLKFVMDGGVLEELEGCPLQL------QELMSRCWQPNPRLRPS 1238


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score =  165 bits (417), Expect = 3e-40
 Identities = 105/301 (34%), Positives = 160/301 (53%), Gaps = 27/301 (8%)

Query: 157 LSRQHLSYLQEIGSGWFGKVILGE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQP 213
           + R+ +    E+G G FGKV L E   +  +     V VK L+ ++    Q  F  EA+ 
Sbjct: 499 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ-DFQREAEL 557

Query: 214 YRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPP-------EGLSPELPP 266
              LQH ++++  G+C E  P L++ E+ + GDL R+LR+  P        E ++P   P
Sbjct: 558 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG--P 615

Query: 267 RDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYY 326
             L  L  +  ++A G+ +L   ++VH DLA RNCL+   L V+IGD+G++   Y  DYY
Sbjct: 616 LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYY 675

Query: 327 LTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDE 386
               R  +P+RW  PE +  L+  F     + ES++WS GV LWE+F +G QP+  LS+ 
Sbjct: 676 RVGGRTMLPIRWMPPESI--LYRKF-----TTESDVWSFGVVLWEIFTYGKQPWYQLSNT 728

Query: 387 EVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDLQLQLTYLLSERP 445
           E +  +   Q  +L RPR   P     Y I++ CW R P QR S  D+  +L   L++ P
Sbjct: 729 EAIDCIT--QGRELERPRACPPEV---YAIMRGCWQREPQQRHSIKDVHARL-QALAQAP 782

Query: 446 P 446
           P
Sbjct: 783 P 783


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score =  165 bits (417), Expect = 3e-40
 Identities = 105/301 (34%), Positives = 160/301 (53%), Gaps = 27/301 (8%)

Query: 157 LSRQHLSYLQEIGSGWFGKVILGE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQP 213
           + R+ +    E+G G FGKV L E   +  +     V VK L+ ++    Q  F  EA+ 
Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ-DFQREAEL 563

Query: 214 YRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPP-------EGLSPELPP 266
              LQH ++++  G+C E  P L++ E+ + GDL R+LR+  P        E ++P   P
Sbjct: 564 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG--P 621

Query: 267 RDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYY 326
             L  L  +  ++A G+ +L   ++VH DLA RNCL+   L V+IGD+G++   Y  DYY
Sbjct: 622 LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYY 681

Query: 327 LTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDE 386
               R  +P+RW  PE +  L+  F     + ES++WS GV LWE+F +G QP+  LS+ 
Sbjct: 682 RVGGRTMLPIRWMPPESI--LYRKF-----TTESDVWSFGVVLWEIFTYGKQPWYQLSNT 734

Query: 387 EVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDLQLQLTYLLSERP 445
           E +  +   Q  +L RPR   P     Y I++ CW R P QR S  D+  +L   L++ P
Sbjct: 735 EAIDCIT--QGRELERPRACPPEV---YAIMRGCWQREPQQRHSIKDVHARL-QALAQAP 788

Query: 446 P 446
           P
Sbjct: 789 P 789


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score =  165 bits (417), Expect = 3e-40
 Identities = 105/301 (34%), Positives = 160/301 (53%), Gaps = 27/301 (8%)

Query: 157 LSRQHLSYLQEIGSGWFGKVILGE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQP 213
           + R+ +    E+G G FGKV L E   +  +     V VK L+ ++    Q  F  EA+ 
Sbjct: 469 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ-DFQREAEL 527

Query: 214 YRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPP-------EGLSPELPP 266
              LQH ++++  G+C E  P L++ E+ + GDL R+LR+  P        E ++P   P
Sbjct: 528 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG--P 585

Query: 267 RDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYY 326
             L  L  +  ++A G+ +L   ++VH DLA RNCL+   L V+IGD+G++   Y  DYY
Sbjct: 586 LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYY 645

Query: 327 LTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDE 386
               R  +P+RW  PE +  L+  F     + ES++WS GV LWE+F +G QP+  LS+ 
Sbjct: 646 RVGGRTMLPIRWMPPESI--LYRKF-----TTESDVWSFGVVLWEIFTYGKQPWYQLSNT 698

Query: 387 EVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDLQLQLTYLLSERP 445
           E +  +   Q  +L RPR   P     Y I++ CW R P QR S  D+  +L   L++ P
Sbjct: 699 EAIDCIT--QGRELERPRACPPEV---YAIMRGCWQREPQQRHSIKDVHARL-QALAQAP 752

Query: 446 P 446
           P
Sbjct: 753 P 753


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score =  158 bits (400), Expect = 3e-38
 Identities = 103/328 (31%), Positives = 170/328 (51%), Gaps = 28/328 (8%)

Query: 121 SSSQSLPDVYILPLAEVSLPMPAPQ------PSHSDMTTPLGLSRQHLSYLQEIGSGWFG 174
           SS  + PD  ++ +  + + +  PQ        H   T    + R+ +   +E+G G FG
Sbjct: 492 SSLDAGPDTVVIGMTRIPV-IENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFG 550

Query: 175 KVILGEIFSDYTPAQVVVKELRASAGP-LEQRK-FISEAQPYRSLQHPNVLQCLGLCVET 232
           KV L E ++       ++  ++A   P L  RK F  EA+   +LQH ++++  G+C + 
Sbjct: 551 KVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 610

Query: 233 LPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRD------LRTLQRMGLEIARGLAHL 286
            P +++ E+ + GDL ++LRA  P   +  +  PR       L  +  +  +IA G+ +L
Sbjct: 611 DPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL 670

Query: 287 HSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGE 346
            S ++VH DLA RNCL+ ++L V+IGD+G++   Y  DYY       +P+RW  PE    
Sbjct: 671 ASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE---- 726

Query: 347 LHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLK 406
              + M    + ES++WS GV LWE+F +G QP+  LS+ EV+  +   Q   L RPR+ 
Sbjct: 727 ---SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECIT--QGRVLERPRV- 780

Query: 407 LPYADYWYDILQSCW-RPPAQRPSASDL 433
                  YD++  CW R P QR +  ++
Sbjct: 781 --CPKEVYDVMLGCWQREPQQRLNIKEI 806


>gi|62420886 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  158 bits (399), Expect = 4e-38
 Identities = 100/300 (33%), Positives = 155/300 (51%), Gaps = 31/300 (10%)

Query: 159 RQHLSYLQEIGSGWFGKVILGEI--------------FSDYTPAQVVVKELRASAGPLEQ 204
           R+ L++ +++G G FG+V L E+               S   P  V VK LRA A    +
Sbjct: 560 RKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNAR 619

Query: 205 RKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPEL 264
             F+ E +    L+ PN++  L +C+   P  +I E+ + GDL ++L    PP   S ++
Sbjct: 620 NDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 679

Query: 265 PPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKED 324
                  L+ M  +IA G+ +L S N+VH DLA RNCL+  + T++I D+G++ + Y  D
Sbjct: 680 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGD 739

Query: 325 YYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEF-GAQPYRHL 383
           YY    R  +P+RW + E +  L G F     +  S++W+ GVTLWE F F   QPY  L
Sbjct: 740 YYRIQGRAVLPIRWMSWESI--LLGKF-----TTASDVWAFGVTLWETFTFCQEQPYSQL 792

Query: 384 SDEEVLA-----FVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQ-RPSASDLQLQL 437
           SDE+V+      F  + +   L +P +     D  Y ++ SCWR   + RPS  ++ L L
Sbjct: 793 SDEQVIENTGEFFRDQGRQTYLPQPAI---CPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849


>gi|62420884 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  158 bits (399), Expect = 4e-38
 Identities = 100/300 (33%), Positives = 155/300 (51%), Gaps = 31/300 (10%)

Query: 159 RQHLSYLQEIGSGWFGKVILGEI--------------FSDYTPAQVVVKELRASAGPLEQ 204
           R+ L++ +++G G FG+V L E+               S   P  V VK LRA A    +
Sbjct: 560 RKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNAR 619

Query: 205 RKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPEL 264
             F+ E +    L+ PN++  L +C+   P  +I E+ + GDL ++L    PP   S ++
Sbjct: 620 NDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 679

Query: 265 PPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKED 324
                  L+ M  +IA G+ +L S N+VH DLA RNCL+  + T++I D+G++ + Y  D
Sbjct: 680 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGD 739

Query: 325 YYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEF-GAQPYRHL 383
           YY    R  +P+RW + E +  L G F     +  S++W+ GVTLWE F F   QPY  L
Sbjct: 740 YYRIQGRAVLPIRWMSWESI--LLGKF-----TTASDVWAFGVTLWETFTFCQEQPYSQL 792

Query: 384 SDEEVLA-----FVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQ-RPSASDLQLQL 437
           SDE+V+      F  + +   L +P +     D  Y ++ SCWR   + RPS  ++ L L
Sbjct: 793 SDEQVIENTGEFFRDQGRQTYLPQPAI---CPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  158 bits (399), Expect = 4e-38
 Identities = 115/398 (28%), Positives = 184/398 (46%), Gaps = 61/398 (15%)

Query: 64  LAPPYA--VVLISCSGLLAFIFLLLTCL-CCKRGDVGFKEFENPEGEDCSGEYTPPAEET 120
           ++P Y+  V++   S    F+ L +T L CC+R     K+++N + E  +   T      
Sbjct: 488 VSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRR----KQWKNKKRESAAVTLT------ 537

Query: 121 SSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLG-------LSRQHLSYLQEIGSGWF 173
               +LP       +E+ L    P P +  M   L          R ++ Y+++IG G F
Sbjct: 538 ----TLP-------SELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAF 586

Query: 174 GKVILGEI--FSDYTP-AQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCV 230
           G+V          Y P   V VK L+  A    Q  F  EA       +PN+++ LG+C 
Sbjct: 587 GRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCA 646

Query: 231 ETLPFLLIMEFCQLGDLKRYLRAQRP--------------PEGLSPELPPRDLRTLQRMG 276
              P  L+ E+   GDL  +LR+  P               +  SP  PP        + 
Sbjct: 647 VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIA 706

Query: 277 LEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPL 336
            ++A G+A+L    +VH DLA RNCL+  ++ V+I D+GL+ + Y  DYY   E   IP+
Sbjct: 707 RQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPI 766

Query: 337 RWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQ 396
           RW  PE       +      + ES++W+ GV LWE+F +G QPY  ++ EEV+ + VR  
Sbjct: 767 RWMPPE-------SIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVI-YYVRDG 818

Query: 397 HVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDL 433
           ++        +      Y++++ CW + PA RPS + +
Sbjct: 819 NILSCPENCPVEL----YNLMRLCWSKLPADRPSFTSI 852


>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
            sapiens]
          Length = 1070

 Score =  156 bits (394), Expect = 2e-37
 Identities = 114/383 (29%), Positives = 188/383 (49%), Gaps = 37/383 (9%)

Query: 66   PPYAVVL---ISCSGLLAFIFLLLTCLC-CKRGDVGFKEFENPEGEDCSGEYT---PPAE 118
            PPY ++    +S    +A+I  +L  +  CK+     +  + PEGE+   E     P   
Sbjct: 697  PPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQN 756

Query: 119  ETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVIL 178
               S++   +V +  L       PA        +  +   R  L  +  +G   FG+V L
Sbjct: 757  GQPSAEIQEEVALTSLGSG----PAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFL 812

Query: 179  GE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPF 235
             +   +        V+VK L+ S    +Q  F  E + +  L H NV++ LGLC E  P 
Sbjct: 813  AKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPH 871

Query: 236  LLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGL--EIARGLAHLHSHNYVH 293
             +++E+  LGDLK++LR  +  +    +L  + L T Q++ L  ++A G+ HL ++ +VH
Sbjct: 872  YMVLEYVDLGDLKQFLRISKSKD---EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVH 928

Query: 294  SDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMV 353
             DLA RNCL+++   V++   GL+   Y  +YY    + W+PLRW +PE +  L G F  
Sbjct: 929  KDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAI--LEGDF-- 983

Query: 354  VDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYA--D 411
               S +S++W+ GV +WE+F  G  P+   +D+EVLA       ++  + RL  P     
Sbjct: 984  ---STKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLA------DLQAGKARLPQPEGCPS 1034

Query: 412  YWYDILQSCWR-PPAQRPSASDL 433
              Y ++Q CW   P  RPS S++
Sbjct: 1035 KLYRLMQRCWALSPKDRPSFSEI 1057


>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
            sapiens]
          Length = 1014

 Score =  156 bits (394), Expect = 2e-37
 Identities = 114/383 (29%), Positives = 188/383 (49%), Gaps = 37/383 (9%)

Query: 66   PPYAVVL---ISCSGLLAFIFLLLTCLC-CKRGDVGFKEFENPEGEDCSGEYT---PPAE 118
            PPY ++    +S    +A+I  +L  +  CK+     +  + PEGE+   E     P   
Sbjct: 641  PPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQN 700

Query: 119  ETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVIL 178
               S++   +V +  L       PA        +  +   R  L  +  +G   FG+V L
Sbjct: 701  GQPSAEIQEEVALTSLGSG----PAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFL 756

Query: 179  GE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPF 235
             +   +        V+VK L+ S    +Q  F  E + +  L H NV++ LGLC E  P 
Sbjct: 757  AKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPH 815

Query: 236  LLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGL--EIARGLAHLHSHNYVH 293
             +++E+  LGDLK++LR  +  +    +L  + L T Q++ L  ++A G+ HL ++ +VH
Sbjct: 816  YMVLEYVDLGDLKQFLRISKSKD---EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVH 872

Query: 294  SDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMV 353
             DLA RNCL+++   V++   GL+   Y  +YY    + W+PLRW +PE +  L G F  
Sbjct: 873  KDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAI--LEGDF-- 927

Query: 354  VDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYA--D 411
               S +S++W+ GV +WE+F  G  P+   +D+EVLA       ++  + RL  P     
Sbjct: 928  ---STKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLA------DLQAGKARLPQPEGCPS 978

Query: 412  YWYDILQSCWR-PPAQRPSASDL 433
              Y ++Q CW   P  RPS S++
Sbjct: 979  KLYRLMQRCWALSPKDRPSFSEI 1001


>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
           [Homo sapiens]
          Length = 940

 Score =  156 bits (394), Expect = 2e-37
 Identities = 114/383 (29%), Positives = 188/383 (49%), Gaps = 37/383 (9%)

Query: 66  PPYAVVL---ISCSGLLAFIFLLLTCLC-CKRGDVGFKEFENPEGEDCSGEYT---PPAE 118
           PPY ++    +S    +A+I  +L  +  CK+     +  + PEGE+   E     P   
Sbjct: 567 PPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQN 626

Query: 119 ETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVIL 178
              S++   +V +  L       PA        +  +   R  L  +  +G   FG+V L
Sbjct: 627 GQPSAEIQEEVALTSLGSG----PAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFL 682

Query: 179 GE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPF 235
            +   +        V+VK L+ S    +Q  F  E + +  L H NV++ LGLC E  P 
Sbjct: 683 AKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPH 741

Query: 236 LLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGL--EIARGLAHLHSHNYVH 293
            +++E+  LGDLK++LR  +  +    +L  + L T Q++ L  ++A G+ HL ++ +VH
Sbjct: 742 YMVLEYVDLGDLKQFLRISKSKD---EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVH 798

Query: 294 SDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMV 353
            DLA RNCL+++   V++   GL+   Y  +YY    + W+PLRW +PE +  L G F  
Sbjct: 799 KDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAI--LEGDF-- 853

Query: 354 VDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYA--D 411
              S +S++W+ GV +WE+F  G  P+   +D+EVLA       ++  + RL  P     
Sbjct: 854 ---STKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLA------DLQAGKARLPQPEGCPS 904

Query: 412 YWYDILQSCWR-PPAQRPSASDL 433
             Y ++Q CW   P  RPS S++
Sbjct: 905 KLYRLMQRCWALSPKDRPSFSEI 927


>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
            sapiens]
          Length = 1030

 Score =  156 bits (394), Expect = 2e-37
 Identities = 114/383 (29%), Positives = 188/383 (49%), Gaps = 37/383 (9%)

Query: 66   PPYAVVL---ISCSGLLAFIFLLLTCLC-CKRGDVGFKEFENPEGEDCSGEYT---PPAE 118
            PPY ++    +S    +A+I  +L  +  CK+     +  + PEGE+   E     P   
Sbjct: 657  PPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQN 716

Query: 119  ETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVIL 178
               S++   +V +  L       PA        +  +   R  L  +  +G   FG+V L
Sbjct: 717  GQPSAEIQEEVALTSLGSG----PAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFL 772

Query: 179  GE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPF 235
             +   +        V+VK L+ S    +Q  F  E + +  L H NV++ LGLC E  P 
Sbjct: 773  AKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPH 831

Query: 236  LLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGL--EIARGLAHLHSHNYVH 293
             +++E+  LGDLK++LR  +  +    +L  + L T Q++ L  ++A G+ HL ++ +VH
Sbjct: 832  YMVLEYVDLGDLKQFLRISKSKD---EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVH 888

Query: 294  SDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMV 353
             DLA RNCL+++   V++   GL+   Y  +YY    + W+PLRW +PE +  L G F  
Sbjct: 889  KDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAI--LEGDF-- 943

Query: 354  VDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYA--D 411
               S +S++W+ GV +WE+F  G  P+   +D+EVLA       ++  + RL  P     
Sbjct: 944  ---STKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLA------DLQAGKARLPQPEGCPS 994

Query: 412  YWYDILQSCWR-PPAQRPSASDL 433
              Y ++Q CW   P  RPS S++
Sbjct: 995  KLYRLMQRCWALSPKDRPSFSEI 1017


>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
           [Homo sapiens]
          Length = 864

 Score =  155 bits (393), Expect = 2e-37
 Identities = 116/385 (30%), Positives = 186/385 (48%), Gaps = 37/385 (9%)

Query: 66  PPYAVVLISCSGLLAFIFLLLTC----LCCKRGDVGFKEFENPEGEDCSGEYTPPAEETS 121
           PP  +VL+      + + LL+ C    L  ++   G +E   P     S E       TS
Sbjct: 421 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLP-----SPELELSKLRTS 475

Query: 122 SSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEI 181
           + ++ P+ Y     +V L      P    +T    +S  +++ L+ +G G FG+V  G +
Sbjct: 476 AIRTAPNPYY---CQVGLGPAQSWPLPPGVTE---VSPANVTLLRALGHGAFGEVYEGLV 529

Query: 182 FS---DYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLI 238
                D +P QV +K L     P ++  F+ EA      +H N+++C+GL +   P L++
Sbjct: 530 IGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLIL 589

Query: 239 MEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLAL 298
           +E    GD+K +LR  RP  G    L  RDL  L +   +IA+G  +L  ++++H D+A 
Sbjct: 590 LELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQ---DIAQGCHYLEENHFIHRDIAA 646

Query: 299 RNCLLT---SDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVD 355
           RNCLL+        +IGD+G+A   Y+  YY   +R  +P++W  PE    L G F    
Sbjct: 647 RNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAF--LEGIF---- 700

Query: 356 QSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYD 415
            + +++ WS GV LWE+F  G  PY   +++EVL FVV    +   R           Y 
Sbjct: 701 -TSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPR-----GCPGPVYR 754

Query: 416 ILQSCWR-PPAQRPSASDLQLQLTY 439
           I+  CW+  P  RPS + +  +L Y
Sbjct: 755 IMTQCWQHEPELRPSFASILERLQY 779


>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
           [Homo sapiens]
          Length = 803

 Score =  155 bits (393), Expect = 2e-37
 Identities = 116/385 (30%), Positives = 186/385 (48%), Gaps = 37/385 (9%)

Query: 66  PPYAVVLISCSGLLAFIFLLLTC----LCCKRGDVGFKEFENPEGEDCSGEYTPPAEETS 121
           PP  +VL+      + + LL+ C    L  ++   G +E   P     S E       TS
Sbjct: 360 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLP-----SPELELSKLRTS 414

Query: 122 SSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEI 181
           + ++ P+ Y     +V L      P    +T    +S  +++ L+ +G G FG+V  G +
Sbjct: 415 AIRTAPNPYY---CQVGLGPAQSWPLPPGVTE---VSPANVTLLRALGHGAFGEVYEGLV 468

Query: 182 FS---DYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLI 238
                D +P QV +K L     P ++  F+ EA      +H N+++C+GL +   P L++
Sbjct: 469 IGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLIL 528

Query: 239 MEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLAL 298
           +E    GD+K +LR  RP  G    L  RDL  L +   +IA+G  +L  ++++H D+A 
Sbjct: 529 LELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQ---DIAQGCHYLEENHFIHRDIAA 585

Query: 299 RNCLLT---SDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVD 355
           RNCLL+        +IGD+G+A   Y+  YY   +R  +P++W  PE    L G F    
Sbjct: 586 RNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAF--LEGIF---- 639

Query: 356 QSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYD 415
            + +++ WS GV LWE+F  G  PY   +++EVL FVV    +   R           Y 
Sbjct: 640 -TSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPR-----GCPGPVYR 693

Query: 416 ILQSCWR-PPAQRPSASDLQLQLTY 439
           I+  CW+  P  RPS + +  +L Y
Sbjct: 694 IMTQCWQHEPELRPSFASILERLQY 718


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  155 bits (391), Expect = 4e-37
 Identities = 94/278 (33%), Positives = 145/278 (52%), Gaps = 28/278 (10%)

Query: 157 LSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRS 216
           L R+ ++ L+E+GSG FG V LG+    Y  A  ++KE     G + + +F  EAQ    
Sbjct: 412 LKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKE-----GSMSEDEFFQEAQTMMK 466

Query: 217 LQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMG 276
           L HP +++  G+C +  P  ++ E+   G L  YLR+    +GL P         L  M 
Sbjct: 467 LSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG--KGLEPS-------QLLEMC 517

Query: 277 LEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPL 336
            ++  G+A L SH ++H DLA RNCL+  DL V++ D+G+      +D Y++      P+
Sbjct: 518 YDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPV 576

Query: 337 RWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQ 396
           +W+APE+       F     S +S++W+ G+ +WE+F  G QPY  L D   +   V Q 
Sbjct: 577 KWSAPEV-------FHYFKYSSKSDVWAFGILMWEVFSLGKQPY-DLYDNSQVVLKVSQG 628

Query: 397 HVKLARPRLKLPYADYWYDILQSCWRP-PAQRPSASDL 433
           H +L RP L    +D  Y I+ SCW   P +RP+   L
Sbjct: 629 H-RLYRPHLA---SDTIYQIMYSCWHELPEKRPTFQQL 662


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  155 bits (391), Expect = 4e-37
 Identities = 94/278 (33%), Positives = 145/278 (52%), Gaps = 28/278 (10%)

Query: 157 LSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRS 216
           L R+ ++ L+E+GSG FG V LG+    Y  A  ++KE     G + + +F  EAQ    
Sbjct: 412 LKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKE-----GSMSEDEFFQEAQTMMK 466

Query: 217 LQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMG 276
           L HP +++  G+C +  P  ++ E+   G L  YLR+    +GL P         L  M 
Sbjct: 467 LSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG--KGLEPS-------QLLEMC 517

Query: 277 LEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPL 336
            ++  G+A L SH ++H DLA RNCL+  DL V++ D+G+      +D Y++      P+
Sbjct: 518 YDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPV 576

Query: 337 RWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQ 396
           +W+APE+       F     S +S++W+ G+ +WE+F  G QPY  L D   +   V Q 
Sbjct: 577 KWSAPEV-------FHYFKYSSKSDVWAFGILMWEVFSLGKQPY-DLYDNSQVVLKVSQG 628

Query: 397 HVKLARPRLKLPYADYWYDILQSCWRP-PAQRPSASDL 433
           H +L RP L    +D  Y I+ SCW   P +RP+   L
Sbjct: 629 H-RLYRPHLA---SDTIYQIMYSCWHELPEKRPTFQQL 662


>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score =  152 bits (384), Expect = 2e-36
 Identities = 99/286 (34%), Positives = 155/286 (54%), Gaps = 24/286 (8%)

Query: 168 IGSGWFGKVILGEIFS-DYTPAQVVVKELRA-SAGPLEQRKFISEAQPYRSLQHPNVLQC 225
           +G G FG V+ G +   D T  +V VK ++  ++   E  +F+SEA   +   HPNV++ 
Sbjct: 593 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRL 652

Query: 226 LGLCVET----LPF-LLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIA 280
           LG+C+E     +P  ++I+ F + GDL  YL   R   G  P+  P  L+TL +  ++IA
Sbjct: 653 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETG--PKHIP--LQTLLKFMVDIA 708

Query: 281 RGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAA 340
            G+ +L + N++H DLA RNC+L  D+TV + D+GL+   Y  DYY       +P++W A
Sbjct: 709 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIA 768

Query: 341 PELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKL 400
            E L +   T        +S++W+ GVT+WE+   G  PY  + + E+  +++    +K 
Sbjct: 769 IESLADRVYT-------SKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 821

Query: 401 ARPRLKLPYADYWYDILQSCWR-PPAQRPSASDLQLQLTYLLSERP 445
               L     D  Y+I+ SCWR  P  RP+ S L+LQL  LL   P
Sbjct: 822 PEDCL-----DELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLP 862


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
           a precursor [Homo sapiens]
          Length = 839

 Score =  150 bits (379), Expect = 9e-36
 Identities = 105/342 (30%), Positives = 173/342 (50%), Gaps = 42/342 (12%)

Query: 121 SSSQSLPDVYILPLAEVSLPMPAPQ------PSHSDMTTPLGLSRQHLSYLQEIGSGWFG 174
           SS  + PD  ++ +  + + +  PQ        H   T    + R+ +   +E+G G FG
Sbjct: 492 SSLDAGPDTVVIGMTRIPV-IENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFG 550

Query: 175 KVILGEIFSDYTPAQVVVKELRASAGP-LEQRK-FISEAQPYRSLQHPNVLQCLGLCVET 232
           KV L E ++       ++  ++A   P L  RK F  EA+   +LQH ++++  G+C + 
Sbjct: 551 KVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDG 610

Query: 233 LPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRD------LRTLQRMGLEIARGLAHL 286
            P +++ E+ + GDL ++LRA  P   +  +  PR       L  +  +  +IA G+ +L
Sbjct: 611 DPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL 670

Query: 287 HSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYY--LTPER----LW------- 333
            S ++VH DLA RNCL+ ++L V+IGD+G++   Y  DYY    P      +W       
Sbjct: 671 ASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHT 730

Query: 334 -IPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFV 392
            +P+RW  PE       + M    + ES++WS GV LWE+F +G QP+  LS+ EV+  +
Sbjct: 731 MLPIRWMPPE-------SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI 783

Query: 393 VRQQHVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDL 433
              Q   L RPR+        YD++  CW R P QR +  ++
Sbjct: 784 T--QGRVLERPRV---CPKEVYDVMLGCWQREPQQRLNIKEI 820


>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
           precursor [Homo sapiens]
          Length = 943

 Score =  150 bits (379), Expect = 9e-36
 Identities = 103/319 (32%), Positives = 156/319 (48%), Gaps = 32/319 (10%)

Query: 134 LAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQ---V 190
           +A  S  M  P  +         +S   + +++E+G   FGKV  G +F      Q   V
Sbjct: 445 MASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAV 504

Query: 191 VVKELRASA-GPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKR 249
            +K L+  A GPL + +F  EA     LQHPNV+  LG+  +  P  +I  +C  GDL  
Sbjct: 505 AIKTLKDKAEGPLRE-EFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHE 563

Query: 250 YLRAQRPPEGLSPELPPRDLRT------LQRMGLEIARGLAHLHSHNYVHSDLALRNCLL 303
           +L  + P   +      R +++         +  +IA G+ +L SH+ VH DLA RN L+
Sbjct: 564 FLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV 623

Query: 304 TSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIW 363
              L V+I D GL    Y  DYY       +P+RW APE +  ++G F +     +S+IW
Sbjct: 624 YDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAI--MYGKFSI-----DSDIW 676

Query: 364 SLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYAD----YWYDILQS 419
           S GV LWE+F +G QPY   S+++V         V++ R R  LP  D    + Y ++  
Sbjct: 677 SYGVVLWEVFSYGLQPYCGYSNQDV---------VEMIRNRQVLPCPDDCPAWVYALMIE 727

Query: 420 CWRP-PAQRPSASDLQLQL 437
           CW   P++RP   D+  +L
Sbjct: 728 CWNEFPSRRPRFKDIHSRL 746



 Score = 31.2 bits (69), Expect = 7.8
 Identities = 47/177 (26%), Positives = 69/177 (38%), Gaps = 28/177 (15%)

Query: 517 AGRGGGAPAWQPASAPPAPHANPSNPFYEA-------LSTPSVLPVISARSPSVSS-EYY 568
           A   G +   Q +S   +P +N SN  Y            P  +P+     P V   + Y
Sbjct: 759 AQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLY 818

Query: 569 IRLEEHGSPPEPLF----PNDWDPLDPGVPAPQAPQAPSEVPQLVSETWASPLFPAPRPF 624
           + +  +G  P P +    PN +    P   APQ  Q P   PQ+V +       P+    
Sbjct: 819 VPV--NGYQPVPAYGAYLPNFYPVQIPMQMAPQ--QVP---PQMVPK-------PSSHHS 864

Query: 625 PAQSSASGSFLL--SGWDPEGRGAGETLAGDPAEVLGERGTAPWVEEEEEEEEGSSP 679
            + S+++G      S      R A  +   D  +   E G    V+E EEEEEGS P
Sbjct: 865 GSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVP 921


>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
           isoform 1 [Homo sapiens]
          Length = 937

 Score =  150 bits (379), Expect = 9e-36
 Identities = 98/308 (31%), Positives = 154/308 (50%), Gaps = 32/308 (10%)

Query: 143 APQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIF-SDYTPAQVV-VKELRASAG 200
           A +P       PL   R    +++E+G   FGK+  G ++      AQ+V +K L+    
Sbjct: 458 AYKPKSKAKELPLSAVR----FMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNN 513

Query: 201 PLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPE-- 258
           P +  +F  EA     L HPN++  LG   +  P  ++ E+   GDL  +L  + P    
Sbjct: 514 PQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDV 573

Query: 259 GLSPELPPRDLRTLQR-----MGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGD 313
           G S +       +L       + ++IA G+ +L SH +VH DLA RN L+   L V+I D
Sbjct: 574 GCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISD 633

Query: 314 YGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELF 373
            GL+   Y  DYY    +  +P+RW  PE +  ++G F     S +S+IWS GV LWE+F
Sbjct: 634 LGLSREIYSADYYRVQSKSLLPIRWMPPEAI--MYGKF-----SSDSDIWSFGVVLWEIF 686

Query: 374 EFGAQPYRHLSDEEVLAFVVRQQHVKLAR---PRLKLPYADYWYDILQSCWRP-PAQRPS 429
            FG QPY   S++EV+  V ++Q +  +    PR+        Y ++  CW   P++RP 
Sbjct: 687 SFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRM--------YSLMTECWNEIPSRRPR 738

Query: 430 ASDLQLQL 437
             D+ ++L
Sbjct: 739 FKDIHVRL 746


>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
          Length = 694

 Score =  147 bits (371), Expect = 7e-35
 Identities = 93/282 (32%), Positives = 149/282 (52%), Gaps = 24/282 (8%)

Query: 157 LSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRS 216
           L+ + L   ++IG G FG+V  G + +D T   V VK  R +  P  + KF+ EA+  + 
Sbjct: 428 LNHEDLVLGEQIGRGNFGEVFSGRLRADNT--LVAVKSCRETLPPDLKAKFLQEARILKQ 485

Query: 217 LQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMG 276
             HPN+++ +G+C +  P  ++ME  Q GD   +LR     EG    +     +TL +M 
Sbjct: 486 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT----EGARLRV-----KTLLQMV 536

Query: 277 LEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPL 336
            + A G+ +L S   +H DLA RNCL+T    ++I D+G++       Y  +     +P+
Sbjct: 537 GDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPV 596

Query: 337 RWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQ 396
           +W APE L   +G +     S ES++WS G+ LWE F  GA PY +LS+++   FV  ++
Sbjct: 597 KWTAPEALN--YGRY-----SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV--EK 647

Query: 397 HVKLARPRLKLPYADYWYDILQSCWR-PPAQRPSASDLQLQL 437
             +L  P L     D  + +++ CW   P QRPS S +  +L
Sbjct: 648 GGRLPCPEL---CPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 686


>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
          Length = 752

 Score =  147 bits (371), Expect = 7e-35
 Identities = 93/282 (32%), Positives = 149/282 (52%), Gaps = 24/282 (8%)

Query: 157 LSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRS 216
           L+ + L   ++IG G FG+V  G + +D T   V VK  R +  P  + KF+ EA+  + 
Sbjct: 486 LNHEDLVLGEQIGRGNFGEVFSGRLRADNT--LVAVKSCRETLPPDLKAKFLQEARILKQ 543

Query: 217 LQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMG 276
             HPN+++ +G+C +  P  ++ME  Q GD   +LR     EG    +     +TL +M 
Sbjct: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT----EGARLRV-----KTLLQMV 594

Query: 277 LEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPL 336
            + A G+ +L S   +H DLA RNCL+T    ++I D+G++       Y  +     +P+
Sbjct: 595 GDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPV 654

Query: 337 RWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQ 396
           +W APE L   +G +     S ES++WS G+ LWE F  GA PY +LS+++   FV  ++
Sbjct: 655 KWTAPEALN--YGRY-----SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV--EK 705

Query: 397 HVKLARPRLKLPYADYWYDILQSCWR-PPAQRPSASDLQLQL 437
             +L  P L     D  + +++ CW   P QRPS S +  +L
Sbjct: 706 GGRLPCPEL---CPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 744


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.136    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,946,339
Number of Sequences: 37866
Number of extensions: 7848532
Number of successful extensions: 172274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1710
Number of HSP's successfully gapped in prelim test: 2808
Number of HSP's that attempted gapping in prelim test: 42098
Number of HSP's gapped (non-prelim): 64285
length of query: 1489
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1374
effective length of database: 13,892,928
effective search space: 19088883072
effective search space used: 19088883072
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.