Search of human proteins with 28178832

Search of human proteins with 28178832

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28178832 isocitrate dehydrogenase 2 (NADP+), mitochondrial
precursor [Homo sapiens]
         (452 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28178832 isocitrate dehydrogenase 2 (NADP+), mitochondrial pr...   932   0.0  
gi|28178825 isocitrate dehydrogenase 1 (NADP+), soluble [Homo sa...   584   e-167
gi|5031777 isocitrate dehydrogenase 3 (NAD+) alpha precursor [Ho...    41   0.002
gi|40807445 protein regulator of cytokinesis 1 isoform 3 [Homo s...    33   0.69 
gi|40807443 protein regulator of cytokinesis 1 isoform 2 [Homo s...    33   0.69 
gi|4506039 protein regulator of cytokinesis 1 isoform 1 [Homo sa...    33   0.69 
gi|32698714 hypothetical protein LOC284058 [Homo sapiens]              30   3.4  
gi|46275820 tetratricopeptide repeat domain 9B [Homo sapiens]          30   3.4  
gi|45580709 unc-93 homolog B1 [Homo sapiens]                           30   3.4  

>gi|28178832 isocitrate dehydrogenase 2 (NADP+), mitochondrial
           precursor [Homo sapiens]
          Length = 452

 Score =  932 bits (2409), Expect = 0.0
 Identities = 452/452 (100%), Positives = 452/452 (100%)

Query: 1   MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR 60
           MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
Sbjct: 1   MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR 60

Query: 61  IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE 120
           IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
Sbjct: 61  IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE 120

Query: 121 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK 180
           ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
Sbjct: 121 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK 180

Query: 181 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI 240
           ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
Sbjct: 181 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI 240

Query: 241 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS 300
           QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
Sbjct: 241 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS 300

Query: 301 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK 360
           SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
Sbjct: 301 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK 360

Query: 361 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH 420
           GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
Sbjct: 361 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH 420

Query: 421 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
           GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
Sbjct: 421 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452


>gi|28178825 isocitrate dehydrogenase 1 (NADP+), soluble [Homo
           sapiens]
          Length = 414

 Score =  584 bits (1505), Expect = e-167
 Identities = 281/397 (70%), Positives = 328/397 (82%), Gaps = 2/397 (0%)

Query: 50  VVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSV 109
           VVEM GDEMTRIIW+ IKEKLI P+V++ L  +DLG+ NRD T+DQVT D+A A +K++V
Sbjct: 10  VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV 69

Query: 110 AVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPIT 169
            VKCATITPDE RVEEFKLK+MWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI 
Sbjct: 70  GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 170 IGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP-AGGVGMGMYNTDESI 228
           IGRHA+GDQY+ATDFV    G  ++ +TP DG+    + V+NF   GGV MGMYN D+SI
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSI 189

Query: 229 SGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHR 288
             FAHS FQ A+ K WPLY+STKNTILK YDGRFKDIFQEI+DK YK+ F+  KIWYEHR
Sbjct: 190 EDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHR 249

Query: 289 LIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAH 348
           LIDDMVAQ +KS GGF+WACKNYDGDVQSD +AQG+GSLG+MTSVLVCPDGKT+EAEAAH
Sbjct: 250 LIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAH 309

Query: 349 GTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVES 408
           GTVTRHYR +QKG+ TSTNPIASIFAWTRGL HR KLD N++L  FA  LE+V +ET+E+
Sbjct: 310 GTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEA 369

Query: 409 GAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNL 445
           G MTKDLA CI GL NV+ ++ +LNT +F+D +  NL
Sbjct: 370 GFMTKDLAACIKGLPNVQRSD-YLNTFEFMDKLGENL 405


>gi|5031777 isocitrate dehydrogenase 3 (NAD+) alpha precursor [Homo
           sapiens]
          Length = 366

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 23/169 (13%)

Query: 251 KNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGF-VWACK 309
           K  I++  DG F    +E+ +      F++         +D +   +++    F V    
Sbjct: 200 KANIMRMSDGLFLQKCREVAESCKDIKFNE-------MYLDTVCLNMVQDPSQFDVLVMP 252

Query: 310 NYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPI 369
           N  GD+ SD+ A   G LG+  S  +  +G  I  E+ HGT                NP 
Sbjct: 253 NLYGDILSDLCAGLIGGLGVTPSGNIGANGVAI-FESVHGTAP------DIAGKDMANPT 305

Query: 370 ASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESG-AMTKDLAG 417
           A + +    L H G  D        A  +E  C  T++ G ++TKDL G
Sbjct: 306 ALLLSAVMMLRHMGLFD-------HAARIEAACFATIKDGKSLTKDLGG 347


>gi|40807445 protein regulator of cytokinesis 1 isoform 3 [Homo
           sapiens]
          Length = 566

 Score = 32.7 bits (73), Expect = 0.69
 Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 14/86 (16%)

Query: 86  LPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS---PNGTIRNI 142
           L N+ QT+ ++   SA  T      +  A  TP +AR    KL     S    N +IR I
Sbjct: 452 LKNKKQTETEMLYGSAPRTPSKRRGL--APNTPGKAR----KLNTTTMSNATANSSIRPI 505

Query: 143 LGGTVFREPIICKNIPRLVPGWTKPI 168
            GGTV+  P     + RL P  +KP+
Sbjct: 506 FGGTVYHSP-----VSRLPPSGSKPV 526


>gi|40807443 protein regulator of cytokinesis 1 isoform 2 [Homo
           sapiens]
          Length = 606

 Score = 32.7 bits (73), Expect = 0.69
 Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 14/86 (16%)

Query: 86  LPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS---PNGTIRNI 142
           L N+ QT+ ++   SA  T      +  A  TP +AR    KL     S    N +IR I
Sbjct: 452 LKNKKQTETEMLYGSAPRTPSKRRGL--APNTPGKAR----KLNTTTMSNATANSSIRPI 505

Query: 143 LGGTVFREPIICKNIPRLVPGWTKPI 168
            GGTV+  P     + RL P  +KP+
Sbjct: 506 FGGTVYHSP-----VSRLPPSGSKPV 526


>gi|4506039 protein regulator of cytokinesis 1 isoform 1 [Homo
           sapiens]
          Length = 620

 Score = 32.7 bits (73), Expect = 0.69
 Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 14/86 (16%)

Query: 86  LPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS---PNGTIRNI 142
           L N+ QT+ ++   SA  T      +  A  TP +AR    KL     S    N +IR I
Sbjct: 452 LKNKKQTETEMLYGSAPRTPSKRRGL--APNTPGKAR----KLNTTTMSNATANSSIRPI 505

Query: 143 LGGTVFREPIICKNIPRLVPGWTKPI 168
            GGTV+  P     + RL P  +KP+
Sbjct: 506 FGGTVYHSP-----VSRLPPSGSKPV 526


>gi|32698714 hypothetical protein LOC284058 [Homo sapiens]
          Length = 1105

 Score = 30.4 bits (67), Expect = 3.4
 Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 2/98 (2%)

Query: 7   VVRSLCRASGS-RPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQF 65
           +VR L  +S S  PA + + +TA TSQ+  RR   +    +   V+ M     TR+    
Sbjct: 822 LVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQ 881

Query: 66  IKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALA 103
            KE L     ++ L+    G P+ +  + +   D+A A
Sbjct: 882 YKEILTPSWREVDLQSLK-GSPDEENEEIEDLSDAAFA 918


>gi|46275820 tetratricopeptide repeat domain 9B [Homo sapiens]
          Length = 239

 Score = 30.4 bits (67), Expect = 3.4
 Identities = 18/49 (36%), Positives = 23/49 (46%)

Query: 4   YLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVE 52
           Y R +  L  A G+RP+  PA    PTS   P R   ++R  V    VE
Sbjct: 88  YHRALLQLKAAQGARPSGLPAPAPGPTSSPGPARLSEEQRRLVESTEVE 136


>gi|45580709 unc-93 homolog B1 [Homo sapiens]
          Length = 597

 Score = 30.4 bits (67), Expect = 3.4
 Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 4/63 (6%)

Query: 32  QEQPRRHYADKRIKVAKPVVEMD-GDEMTRIIWQFIKEKLILPHVD---IQLKYFDLGLP 87
           +E+ RR+Y  KR+ V K V+    G  +T  ++  + +  ++ H D    ++KY ++GLP
Sbjct: 46  EEEERRYYRRKRLGVLKNVLAASAGGMLTYGVYLGLLQMQLILHYDETYREVKYGNMGLP 105

Query: 88  NRD 90
           + D
Sbjct: 106 DID 108


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,344,415
Number of Sequences: 37866
Number of extensions: 774345
Number of successful extensions: 1792
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1787
Number of HSP's gapped (non-prelim): 9
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.