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Search of human proteins with 27436917
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo
sapiens]
(1332 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 2714 0.0
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 2662 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 2615 0.0
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 2608 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 1656 0.0
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 1651 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 1641 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 1635 0.0
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 1572 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 1566 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 1566 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 1561 0.0
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 1552 0.0
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 1472 0.0
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 791 0.0
gi|118600963 Nik related kinase [Homo sapiens] 405 e-112
gi|145275208 myosin IIIA [Homo sapiens] 310 8e-84
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 292 2e-78
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 292 2e-78
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 264 4e-70
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 262 2e-69
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 257 5e-68
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 257 5e-68
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 256 8e-68
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 256 1e-67
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 253 9e-67
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 249 1e-65
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 249 1e-65
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 243 7e-64
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 242 2e-63
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 2714 bits (7035), Expect = 0.0
Identities = 1332/1332 (100%), Positives = 1332/1332 (100%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 720
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 720
Query: 721 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 780
PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 721 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 780
Query: 781 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 840
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
Sbjct: 781 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 840
Query: 841 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 900
EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
Sbjct: 841 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 900
Query: 901 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 960
ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
Sbjct: 901 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 960
Query: 961 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1020
QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
Sbjct: 961 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1020
Query: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080
EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
Sbjct: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080
Query: 1081 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1140
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
Sbjct: 1081 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1140
Query: 1141 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1200
YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
Sbjct: 1141 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1200
Query: 1201 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1260
YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
Sbjct: 1201 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1260
Query: 1261 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1320
ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1261 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1320
Query: 1321 FMTLNRNCIMNW 1332
FMTLNRNCIMNW
Sbjct: 1321 FMTLNRNCIMNW 1332
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 2662 bits (6901), Expect = 0.0
Identities = 1312/1332 (98%), Positives = 1312/1332 (98%), Gaps = 20/1332 (1%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL------------------ 582
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 583 --QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 640
Query: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 720
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
Sbjct: 641 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 700
Query: 721 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 780
PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 701 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 760
Query: 781 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 840
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
Sbjct: 761 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 820
Query: 841 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 900
EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
Sbjct: 821 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 880
Query: 901 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 960
ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
Sbjct: 881 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 940
Query: 961 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1020
QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
Sbjct: 941 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1000
Query: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080
EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
Sbjct: 1001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1060
Query: 1081 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1140
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
Sbjct: 1061 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1120
Query: 1141 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1200
YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
Sbjct: 1121 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1180
Query: 1201 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1260
YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
Sbjct: 1181 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1240
Query: 1261 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1320
ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1241 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1300
Query: 1321 FMTLNRNCIMNW 1332
FMTLNRNCIMNW
Sbjct: 1301 FMTLNRNCIMNW 1312
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 2615 bits (6778), Expect = 0.0
Identities = 1295/1332 (97%), Positives = 1295/1332 (97%), Gaps = 37/1332 (2%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 720
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA------------------------- 695
Query: 721 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 780
SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 696 ------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 743
Query: 781 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 840
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
Sbjct: 744 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 803
Query: 841 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 900
EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
Sbjct: 804 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 863
Query: 901 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 960
ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
Sbjct: 864 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 923
Query: 961 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1020
QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
Sbjct: 924 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 983
Query: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080
EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
Sbjct: 984 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1043
Query: 1081 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1140
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
Sbjct: 1044 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1103
Query: 1141 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1200
YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
Sbjct: 1104 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1163
Query: 1201 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1260
YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
Sbjct: 1164 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1223
Query: 1261 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1320
ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1224 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1283
Query: 1321 FMTLNRNCIMNW 1332
FMTLNRNCIMNW
Sbjct: 1284 FMTLNRNCIMNW 1295
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 2608 bits (6759), Expect = 0.0
Identities = 1295/1340 (96%), Positives = 1295/1340 (96%), Gaps = 45/1340 (3%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 720
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA------------------------- 695
Query: 721 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 780
SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 696 ------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 743
Query: 781 LSPGNKAKPDDHRSRPGRPA--------DFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 832
LSPGNKAKPDDHRSRPGRPA DFVLLKERTLDEAPRPPKKAMDYSSSSEEVES
Sbjct: 744 LSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 803
Query: 833 SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP 892
SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP
Sbjct: 804 SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP 863
Query: 893 EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT 952
EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT
Sbjct: 864 EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT 923
Query: 953 MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR 1012
MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR
Sbjct: 924 MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR 983
Query: 1013 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1072
KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL
Sbjct: 984 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1043
Query: 1073 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1132
ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI
Sbjct: 1044 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1103
Query: 1133 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1192
ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV
Sbjct: 1104 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1163
Query: 1193 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1252
DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG
Sbjct: 1164 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1223
Query: 1253 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1312
EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1224 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1283
Query: 1313 SGGSSQVYFMTLNRNCIMNW 1332
SGGSSQVYFMTLNRNCIMNW
Sbjct: 1284 SGGSSQVYFMTLNRNCIMNW 1303
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 1656 bits (4289), Expect = 0.0
Identities = 899/1392 (64%), Positives = 1037/1392 (74%), Gaps = 129/1392 (9%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Query: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
K + +P +P S ++TPPM RPV+PQ + H V +K +
Sbjct: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
Query: 598 RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 578 ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
Query: 653 -NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRA 711
+ +W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 627 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ--------- 673
Query: 712 ERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----G 756
P +SNPDLRR++P E S S P+S G
Sbjct: 674 -----------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGG 716
Query: 757 HLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KE 807
P QAGS ER RV +SK + SPVL K KP++ R +RP RPAD L +E
Sbjct: 717 SQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRE 776
Query: 808 RTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGD 859
++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G +
Sbjct: 777 LRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNE 836
Query: 860 TDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPD 911
+V + H +E T + G GT++++ T E++ H+DSNG+ NLPD
Sbjct: 837 QYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPD 894
Query: 912 VVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSG 966
+VQ SHSP TE S S++ SG G + K+SFT FVD +YQ +
Sbjct: 895 LVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTD 951
Query: 967 DS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1020
+ AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNS
Sbjct: 952 EDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNS 1011
Query: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080
EILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+N
Sbjct: 1012 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKN 1071
Query: 1081 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1140
KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+
Sbjct: 1072 KLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEI 1131
Query: 1141 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1200
YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDI
Sbjct: 1132 YAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDI 1191
Query: 1201 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1260
YIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAY
Sbjct: 1192 YIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1251
Query: 1261 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1320
I SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+
Sbjct: 1252 IHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVF 1311
Query: 1321 FMTLNRNCIMNW 1332
FMTLNRN +MNW
Sbjct: 1312 FMTLNRNSMMNW 1323
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 1651 bits (4275), Expect = 0.0
Identities = 898/1400 (64%), Positives = 1037/1400 (74%), Gaps = 137/1400 (9%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Query: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
K + +P +P S ++TPPM RPV+PQ + H V +K +
Sbjct: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
Query: 598 RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 578 ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
Query: 653 -NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRA 711
+ +W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 627 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ--------- 673
Query: 712 ERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----G 756
P +SNPDLRR++P E S S P+S G
Sbjct: 674 -----------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGG 716
Query: 757 HLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVL------- 804
P QAGS ER RV +SK + SPVL K KP++ R +RP RPA +
Sbjct: 717 SQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLT 776
Query: 805 -----LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP---- 852
L+E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P
Sbjct: 777 ALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIP 836
Query: 853 -GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGY 906
G + +V + H +E T + G GT++++ T E++ H+DSNG+
Sbjct: 837 TGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGF 894
Query: 907 T---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLG 958
NLPD+VQ SHSP TE S S++ SG G + K+SFT FVD
Sbjct: 895 AGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPR 951
Query: 959 IYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIR 1012
+YQ + + AL E R +Q + + RK SVVNVNPTN R HS+TPEIR
Sbjct: 952 VYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIR 1011
Query: 1013 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1072
KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L
Sbjct: 1012 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVL 1071
Query: 1073 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1132
+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVI
Sbjct: 1072 VTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVI 1131
Query: 1133 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1192
ALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DV
Sbjct: 1132 ALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDV 1191
Query: 1193 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1252
DSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWG
Sbjct: 1192 DSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWG 1251
Query: 1253 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1312
EMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1252 EMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1311
Query: 1313 SGGSSQVYFMTLNRNCIMNW 1332
SGGSSQV+FMTLNRN +MNW
Sbjct: 1312 SGGSSQVFFMTLNRNSMMNW 1331
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 1641 bits (4249), Expect = 0.0
Identities = 899/1421 (63%), Positives = 1037/1421 (72%), Gaps = 158/1421 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
QE+EQ+R E+ +RREEERR+AE EQEY
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
Query: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
Query: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
RPV+PQ + H V +K + SQS+ +QPT+ L+ F + +
Sbjct: 585 LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627
Query: 629 TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATALNTS 682
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL
Sbjct: 628 VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686
Query: 683 GAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDP 742
+ G+ A PR S P +SNPDLRR++P
Sbjct: 687 NSPGNGSALG----PRLGSQ--------------------------PIRASNPDLRRTEP 716
Query: 743 GWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PG 784
E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 717 ILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEP 776
Query: 785 NKAKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEE 838
K KP++ R +RP RPAD L +E ++E RP KK DYSSSSEE ESSE++EE
Sbjct: 777 AKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEE 836
Query: 839 EGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GT 885
+GE +G+ D P G + +V + H +E T + G GT
Sbjct: 837 DGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGT 894
Query: 886 MVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDY 937
++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++ SG
Sbjct: 895 LMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTE 954
Query: 938 QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRK 991
G + K+SFT FVD +YQ + + AL E R +Q + + RK
Sbjct: 955 YGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARK 1011
Query: 992 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1051
SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
Sbjct: 1012 ISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1071
Query: 1052 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG 1111
Y LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVG
Sbjct: 1072 YNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG 1131
Query: 1112 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV 1171
D+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTV
Sbjct: 1132 DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTV 1191
Query: 1172 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE 1231
EEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYE
Sbjct: 1192 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYE 1251
Query: 1232 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1291
DEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHK
Sbjct: 1252 DEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHK 1311
Query: 1292 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1332
RAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1312 RAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 1635 bits (4235), Expect = 0.0
Identities = 898/1429 (62%), Positives = 1037/1429 (72%), Gaps = 166/1429 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
QE+EQ+R E+ +RREEERR+AE EQEY
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
Query: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
Query: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
RPV+PQ + H V +K + SQS+ +QPT+ L+ F + +
Sbjct: 585 LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627
Query: 629 TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATALNTS 682
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL
Sbjct: 628 VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686
Query: 683 GAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDP 742
+ G+ A PR S P +SNPDLRR++P
Sbjct: 687 NSPGNGSALG----PRLGSQ--------------------------PIRASNPDLRRTEP 716
Query: 743 GWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PG 784
E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 717 ILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEP 776
Query: 785 NKAKPDDHR--SRPGRPADFVL------------LKERTLDEAPRPPKKAMDYSSSSEEV 830
K KP++ R +RP RPA + L+E ++E RP KK DYSSSSEE
Sbjct: 777 AKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEES 836
Query: 831 ESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYG 882
ESSE++EE+GE +G+ D P G + +V + H +E T +
Sbjct: 837 ESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFS 894
Query: 883 G-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPS 930
G GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S
Sbjct: 895 GSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHS 954
Query: 931 KD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQ 984
++ SG G + K+SFT FVD +YQ + + AL E R +Q
Sbjct: 955 QEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQ 1011
Query: 985 LQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 1043
+ + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL
Sbjct: 1012 AKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 1071
Query: 1044 DRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEK 1103
DRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEK
Sbjct: 1072 DRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEK 1131
Query: 1104 KQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHR 1163
KQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+
Sbjct: 1132 KQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHK 1191
Query: 1164 PLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDG 1223
PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDG
Sbjct: 1192 PLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG 1251
Query: 1224 MEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGH 1283
MEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGH
Sbjct: 1252 MEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGH 1311
Query: 1284 LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1332
LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1312 LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 1572 bits (4070), Expect = 0.0
Identities = 872/1389 (62%), Positives = 998/1389 (71%), Gaps = 178/1389 (12%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q +Q+Q R VE++ PL
Sbjct: 476 HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
K G + P ++P +E PH V +K + SQ
Sbjct: 493 KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P P +
Sbjct: 526 SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
Query: 655 PAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERG 714
+W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 575 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ------------ 618
Query: 715 TPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----GHLP 759
P +SNPDLRR++P E S S P+S G P
Sbjct: 619 --------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQP 664
Query: 760 --QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KERTL 810
QAGS ER RV +SK + SPVL K KP++ R +RP RPAD L +E +
Sbjct: 665 GSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRI 724
Query: 811 DEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDS 862
+E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G + +
Sbjct: 725 EETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYN 784
Query: 863 VSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQ 914
V + H +E T + G GT++++ T E++ H+DSNG+ NLPD+VQ
Sbjct: 785 VGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQ 842
Query: 915 PSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS- 968
SHSP TE S S++ SG G + K+SFT FVD +YQ + +
Sbjct: 843 QSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDE 899
Query: 969 ----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEIL 1023
AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEIL
Sbjct: 900 EDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEIL 959
Query: 1024 CAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLR 1083
CAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLR
Sbjct: 960 CAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLR 1019
Query: 1084 VYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAW 1143
VYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAW
Sbjct: 1020 VYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAW 1079
Query: 1144 APKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIP 1203
APKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP
Sbjct: 1080 APKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIP 1139
Query: 1204 VHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICS 1263
HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI S
Sbjct: 1140 SHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHS 1199
Query: 1264 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1323
NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMT
Sbjct: 1200 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMT 1259
Query: 1324 LNRNCIMNW 1332
LNRN +MNW
Sbjct: 1260 LNRNSMMNW 1268
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 1566 bits (4056), Expect = 0.0
Identities = 871/1397 (62%), Positives = 998/1397 (71%), Gaps = 186/1397 (13%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q +Q+Q R VE++ PL
Sbjct: 476 HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
K G + P ++P +E PH V +K + SQ
Sbjct: 493 KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P P +
Sbjct: 526 SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
Query: 655 PAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERG 714
+W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 575 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ------------ 618
Query: 715 TPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----GHLP 759
P +SNPDLRR++P E S S P+S G P
Sbjct: 619 --------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQP 664
Query: 760 --QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVL---------- 804
QAGS ER RV +SK + SPVL K KP++ R +RP RPA +
Sbjct: 665 GSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALA 724
Query: 805 --LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GG 854
L+E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G
Sbjct: 725 KELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGA 784
Query: 855 RSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT-- 907
+ +V + H +E T + G GT++++ T E++ H+DSNG+
Sbjct: 785 PGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGH 842
Query: 908 -NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQ 961
NLPD+VQ SHSP TE S S++ SG G + K+SFT FVD +YQ
Sbjct: 843 INLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQ 899
Query: 962 PGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYK 1015
+ + AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYK
Sbjct: 900 TSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYK 959
Query: 1016 KRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITI 1075
KRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TI
Sbjct: 960 KRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTI 1019
Query: 1076 SGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALK 1135
SGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK
Sbjct: 1020 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALK 1079
Query: 1136 SSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSG 1195
++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSG
Sbjct: 1080 NAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSG 1139
Query: 1196 NSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMP 1255
NSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMP
Sbjct: 1140 NSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMP 1199
Query: 1256 TSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGG 1315
TSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGG
Sbjct: 1200 TSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGG 1259
Query: 1316 SSQVYFMTLNRNCIMNW 1332
SSQV+FMTLNRN +MNW
Sbjct: 1260 SSQVFFMTLNRNSMMNW 1276
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 1566 bits (4055), Expect = 0.0
Identities = 868/1393 (62%), Positives = 1001/1393 (71%), Gaps = 157/1393 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE-QRQSERLQRQLQQEHAYLKSL 479
QE+EQ+R E+ +RREEERR+AE EQEY R+QLEE QRQ E LQ+QL E A L
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 480 QQQQQQQQLQKQQQQQLLPGDRK---PLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
+++Q ++Q Q ++ Q+ L +R L H + P +K P
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK------------------KP 517
Query: 537 LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV 596
L K G + P ++P +E PH V +K +
Sbjct: 518 LYHYKEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPAL 550
Query: 597 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP---- 652
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 551 TASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIE 599
Query: 653 --NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRR 710
+ +W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 600 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ-------- 647
Query: 711 AERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH----- 755
P +SNPDLRR++P E S S P+S
Sbjct: 648 ------------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 689
Query: 756 GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----K 806
G P QAGS ER RV +SK + SPVL K KP++ R +RP RPAD L +
Sbjct: 690 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELR 749
Query: 807 ERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDG 858
E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G
Sbjct: 750 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 809
Query: 859 DTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLP 910
+ +V + H +E T + G GT++++ T E++ H+DSNG+ NLP
Sbjct: 810 EQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLP 867
Query: 911 DVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGS 965
D+VQ SHSP TE S S++ SG G + K+SFT FVD +YQ +
Sbjct: 868 DLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPT 924
Query: 966 GDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFN 1019
+ AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFN
Sbjct: 925 DEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFN 984
Query: 1020 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKR 1079
SEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+
Sbjct: 985 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK 1044
Query: 1080 NKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVE 1139
NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE
Sbjct: 1045 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE 1104
Query: 1140 VYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYD 1199
+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYD
Sbjct: 1105 IYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYD 1164
Query: 1200 IYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVA 1259
IYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVA
Sbjct: 1165 IYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVA 1224
Query: 1260 YICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV 1319
YI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV
Sbjct: 1225 YIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV 1284
Query: 1320 YFMTLNRNCIMNW 1332
+FMTLNRN +MNW
Sbjct: 1285 FFMTLNRNSMMNW 1297
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 1561 bits (4041), Expect = 0.0
Identities = 867/1401 (61%), Positives = 1001/1401 (71%), Gaps = 165/1401 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE-QRQSERLQRQLQQEHAYLKSL 479
QE+EQ+R E+ +RREEERR+AE EQEY R+QLEE QRQ E LQ+QL E A L
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 480 QQQQQQQQLQKQQQQQLLPGDRK---PLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
+++Q ++Q Q ++ Q+ L +R L H + P +K P
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK------------------KP 517
Query: 537 LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV 596
L K G + P ++P +E PH V +K +
Sbjct: 518 LYHYKEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPAL 550
Query: 597 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP---- 652
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 551 TASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIE 599
Query: 653 --NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRR 710
+ +W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 600 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ-------- 647
Query: 711 AERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH----- 755
P +SNPDLRR++P E S S P+S
Sbjct: 648 ------------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 689
Query: 756 GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVL------ 804
G P QAGS ER RV +SK + SPVL K KP++ R +RP RPA +
Sbjct: 690 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDL 749
Query: 805 ------LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP--- 852
L+E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P
Sbjct: 750 TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI 809
Query: 853 --GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNG 905
G + +V + H +E T + G GT++++ T E++ H+DSNG
Sbjct: 810 PTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNG 867
Query: 906 YT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDL 957
+ NLPD+VQ SHSP TE S S++ SG G + K+SFT FVD
Sbjct: 868 FAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDP 924
Query: 958 GIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEI 1011
+YQ + + AL E R +Q + + RK SVVNVNPTN R HS+TPEI
Sbjct: 925 RVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEI 984
Query: 1012 RKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNL 1071
RKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+
Sbjct: 985 RKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNV 1044
Query: 1072 LITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLV 1131
L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLV
Sbjct: 1045 LVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLV 1104
Query: 1132 IALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVD 1191
IALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +D
Sbjct: 1105 IALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVID 1164
Query: 1192 VDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQW 1251
VDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQW
Sbjct: 1165 VDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQW 1224
Query: 1252 GEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV 1311
GEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV
Sbjct: 1225 GEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV 1284
Query: 1312 RSGGSSQVYFMTLNRNCIMNW 1332
RSGGSSQV+FMTLNRN +MNW
Sbjct: 1285 RSGGSSQVFFMTLNRNSMMNW 1305
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 1552 bits (4018), Expect = 0.0
Identities = 874/1406 (62%), Positives = 989/1406 (70%), Gaps = 160/1406 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 420 KLQEKEQQRR-------LEDMQALRREEE--------RRQAEREQEYKRKQLEEQ----- 459
+ QE+EQ+RR LE+++ R+EEE +R+ EREQEY R+QLEE+
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 460 ------------------------RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
RQ+ERLQRQLQQE AYL SLQ ++ Q QQ
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 496 LLPGDR-KPLYHYGRGM---NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPI 551
+R KP +H PAD+ AREVE+R R +SP A+SK EPP+
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADR---AREVEDRFRKTNH-SSPEAQSKQTGRVLEPPV 596
Query: 552 PQASPGPPGPLSQT--PPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRN 609
P S S++ P +QRP EPQ +H LK +PV RS S D +
Sbjct: 597 PSRSESFSNGNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSRSHSFSDPSPKF 651
Query: 610 LAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDN-EAPPKV 668
S DP P +R V+ Q+SD SE P P+ AW R D+ E PP+V
Sbjct: 652 AHHHLRSQDP---------CPPSRSEVLSQSSDSKSEAPDPTQK--AWSRSDSDEVPPRV 700
Query: 669 PQRTSSIATALNTSGA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQ 724
P RT+S + L+ + G + +QA + R ++S L R E+ P+P +
Sbjct: 701 PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLVPRPGSGSSS 759
Query: 725 PPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPG 784
G N+ S P S PG Q+GS ER RV SSK + SP
Sbjct: 760 --GSSNSGSQPG---SHPG---------------SQSGSGERFRVRSSSKSEGSPSQRLE 799
Query: 785 NKAK-PDDHRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESS 833
N K P+D + RP +PA V L KE E RPP K DYSSSSEE E
Sbjct: 800 NAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEED 859
Query: 834 EDDEEEGEGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQ 889
+D E+EG G DT S +G+T+SV TM+VHD E P GT++V+
Sbjct: 860 DDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVR 919
Query: 890 RTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKS 949
+T S L K S
Sbjct: 920 QTQSA--------------------------------------------SSTLQKHKSSS 935
Query: 950 SFTMFVDLGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHS 1006
SFT F+D + Q S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S
Sbjct: 936 SFTPFIDPRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQS 994
Query: 1007 ETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVL 1066
+TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVL
Sbjct: 995 DTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVL 1054
Query: 1067 EGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYER 1126
EGLN+L+TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYER
Sbjct: 1055 EGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYER 1114
Query: 1127 IKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAG 1186
IKFLVIALKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AG
Sbjct: 1115 IKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAG 1174
Query: 1187 FHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKD 1246
FHAVDVDSG+ YDIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KD
Sbjct: 1175 FHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD 1234
Query: 1247 VVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1306
VVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
Sbjct: 1235 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1294
Query: 1307 FFASVRSGGSSQVYFMTLNRNCIMNW 1332
FFASVRSGGSSQVYFMTL R +++W
Sbjct: 1295 FFASVRSGGSSQVYFMTLGRTSLLSW 1320
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 1472 bits (3810), Expect = 0.0
Identities = 824/1355 (60%), Positives = 945/1355 (69%), Gaps = 166/1355 (12%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
+ QE+EQ+RR +EE+R+ E E E +RK+ EE+R++E +R++++E Y++
Sbjct: 421 RQQEREQRRR--------EQEEKRRLE-ELERRRKEEEERRRAEEEKRRVEREQEYIR-- 469
Query: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539
+Q +++Q+ + QQQLL L+ + R
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAMLLHDHRR------------------------------ 499
Query: 540 SKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRS 599
P PQ S PP PP Q +P H K + P R+
Sbjct: 500 ----------PHPQHSQQPP------PPQQERSKPS--------FHAPEPKAHYEPADRA 535
Query: 600 QSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVR 659
+ ++D+ + + P + PS + NS+ PA R
Sbjct: 536 REVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVH---------PALQR 586
Query: 660 PDNEAPPKVPQRTSSIATALNTSGA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGT 715
P A P+VP RT+S + L+ + G + +QA + R ++S L R E+
Sbjct: 587 P---AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLV 642
Query: 716 PKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKP 775
P+P + G N+ S P S PG Q+GS ER RV SSK
Sbjct: 643 PRPGSGSSS--GSSNSGSQPG---SHPG---------------SQSGSGERFRVRSSSKS 682
Query: 776 DSSPVLSPGNKAK-PDDHRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSE 828
+ SP N K P+D + RP +PA V L KE E RPP K DYSSSSE
Sbjct: 683 EGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSE 742
Query: 829 EV----ESSEDDEEEGEGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPP 880
E E +D E+EG G DT S +G+T+SV TM+VHD E P
Sbjct: 743 ESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTP 802
Query: 881 YGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSR 940
GT++V++T S
Sbjct: 803 SKEGTLIVRQTQSA--------------------------------------------SS 818
Query: 941 GLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNV 997
L K SSFT F+D + Q S + +T++VG +G R + ++ D RKGSVVNV
Sbjct: 819 TLQKHKSSSSFTPFIDPRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNV 877
Query: 998 NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR 1057
NPTNTR S+TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI R
Sbjct: 878 NPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINR 937
Query: 1058 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG 1117
RRFQQMDVLEGLN+L+TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC
Sbjct: 938 RRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCV 997
Query: 1118 HYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL 1177
HY+VVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRL
Sbjct: 998 HYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRL 1057
Query: 1178 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYV 1237
KVIYGS AGFHAVDVDSG+ YDIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVYV
Sbjct: 1058 KVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYV 1117
Query: 1238 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK 1297
NTYGRI KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLK
Sbjct: 1118 NTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK 1177
Query: 1298 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1332
FLCERNDKVFFASVRSGGSSQVYFMTL R +++W
Sbjct: 1178 FLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 791 bits (2044), Expect = 0.0
Identities = 418/566 (73%), Positives = 465/566 (82%), Gaps = 33/566 (5%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 420 KLQEKEQ-------QRRLEDMQALRR--------EEERRQAEREQEYKRKQL-EEQRQSE 463
+ QE+EQ +RRLE+++ R+ EEE+R+ EREQEY R+QL EEQR E
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 464 RLQRQLQQEHAYLKSLQQQ---QQQQQLQKQQQQQLLPGDR--KPLYHYGRGMNPADKPA 518
LQ+QL QE A L ++ Q QQ QQ++ P +P HY PAD+
Sbjct: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHY----EPADR-- 534
Query: 519 WAREVEERTRMN----KQQNSPLAKS 540
AREV RT +++SPL S
Sbjct: 535 -AREVPVRTTSRSPVLSRRDSPLQGS 559
Score = 719 bits (1855), Expect = 0.0
Identities = 472/1012 (46%), Positives = 576/1012 (56%), Gaps = 161/1012 (15%)
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
+ S + LK Q +R +K H+ R++R E+ + E ++ E
Sbjct: 276 QRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPE 335
Query: 420 KLQEKEQQRRLEDMQALRREEERRQAE---REQEYKRKQL---EEQRQSERLQRQLQQEH 473
+ E + LRR+ R Q E R + +R+QL ++ R+ E +RQL E
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAER 395
Query: 474 AYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQ 533
K ++QQ++Q++ ++QQ++ R+ ++ RE EE+ R+ + +
Sbjct: 396 Q--KRIEQQKEQRRRLEEQQRREREARRQQ-----------EREQRRREQEEKRRLEELE 442
Query: 534 NSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYA 593
+ + E +R QE + L + L+
Sbjct: 443 RRRKEEEERRRAEEEK-------------------RRVEREQEYIRRQLEEEQRHLE--- 480
Query: 594 APVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPS-- 651
V + Q LQ+Q HD P + P P E PS
Sbjct: 481 --VLQQQLLQEQAM-------LLHDHRRPHPQHSQQPPP----------PQQERSKPSFH 521
Query: 652 -PNPPAWVRPDNEAPPKVPQRTSSIATALNTSGA----GGSRPAQAVRARPRSNSAWQIY 706
P P A P + A +VP RT+S + L+ + G + +QA + R ++S
Sbjct: 522 APEPKAHYEPADRAR-EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRL 579
Query: 707 LQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLER 766
L R E+ P+P + G N+ S P S PG Q+GS ER
Sbjct: 580 LWERVEKLVPRPGSGSSS--GSSNSGSQPG---SHPG---------------SQSGSGER 619
Query: 767 NRVGVSSKPDSSPVLSPGNKAK-PDDHRS--RPGRPADFV----LLKERTLDEAPRPPKK 819
RV SSK + SP N K P+D + RP +PA V L KE E RPP K
Sbjct: 620 FRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHK 679
Query: 820 AMDYSSSSEEV----ESSEDDEEEGEGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDV 871
DYSSSSEE E +D E+EG G DT S +G+T+SV TM+VHD
Sbjct: 680 VTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDD 739
Query: 872 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK 931
E P GT++V++T
Sbjct: 740 VESEPAMTPSKEGTLIVRQTQSA------------------------------------- 762
Query: 932 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD- 988
S L K SSFT F+D + Q S + +T++VG +G R + ++ D
Sbjct: 763 -------SSTLQKHKSSSSFTPFIDPRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDP 814
Query: 989 VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQ 1048
RKGSVVNVNPTNTR S+TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQ
Sbjct: 815 TRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQ 874
Query: 1049 GKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWT 1108
GKVY LI RRRFQQMDVLEGLN+L+TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWT
Sbjct: 875 GKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWT 934
Query: 1109 TVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVD 1168
TVGD+EGC HY+VVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVD
Sbjct: 935 TVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVD 994
Query: 1169 LTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVH--------IQSQITPHAIIFLPN 1220
LTVEEGQRLKVIYGS AGFHAVDVDSG+ YDIY+P H IQ I PHAII LPN
Sbjct: 995 LTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPN 1054
Query: 1221 TDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE 1280
TDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVE
Sbjct: 1055 TDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVE 1114
Query: 1281 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1332
TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL R +++W
Sbjct: 1115 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 405 bits (1041), Expect = e-112
Identities = 244/601 (40%), Positives = 340/601 (56%), Gaps = 74/601 (12%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M P R + DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+ +
Sbjct: 1 MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
Query: 61 ------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG 96
DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG
Sbjct: 61 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
Query: 97 NDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKG 156
QLW+VME C AGSVTD+V+ T +LKED IAYICREIL+GLAHLHAH+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDI 216
QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YDYRSD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS 276
WS+GITAIEMAEGAPPLC++ P+ ALF+I R P +KS WS+KF +F++ C IK +L
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
Query: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDH---IDRSRKKRG-----EKEET-EYEYSGSE 327
RP + +L+ PF+RD ER V L H I + R+K+G E+EE + +Y+
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
Query: 328 EEDDS--------------------HGEEGEP-----------SSIMNVPGESTLRREFL 356
S HGE +P ++ + G + R F+
Sbjct: 361 FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAA---RVFM 417
Query: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
LQ + S + LK Q Q Q+ Q + Q Q + + K + +++ R R
Sbjct: 418 PLQALD-SAPKPLKGQAQAPQRLQGAARVFMP---LQAQVKAKASKPLQMQIKAPPRLRR 473
Query: 417 EQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYL 476
R L + Q R + ++ + ++Q + Q + + L++ + + Q Q+ ++
Sbjct: 474 AARVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQG 533
Query: 477 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
++ +QQQ+ Q+ +Q+ +Q ++ + + PA A E E R+N Q P
Sbjct: 534 QAPEQQQRHNQVPEQELEQNQAPEQPEVQE--QAAEPAQAETEAEE-PESLRVNAQVFLP 590
Query: 537 L 537
L
Sbjct: 591 L 591
Score = 282 bits (721), Expect = 2e-75
Identities = 186/589 (31%), Positives = 287/589 (48%), Gaps = 76/589 (12%)
Query: 812 EAPRPPKKAM--DYSSSSEEVESSEDDEEEGEG-GPAEGSRDTPGGRSDGDTDSVSTMVV 868
EAP P+ + D S + + S EE G G +R G + D ++
Sbjct: 986 EAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEE 1045
Query: 869 HDVEEITGTQPPYGGGTMVVQRTPEEERNL-LHADSN-GYTNLPDVVQPSHSPTENSKGQ 926
H + + G G V RT EE L L+ + N T+ P + +P+ E + +
Sbjct: 1046 HAANIGSERRGSEGDGGKGVVRTSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEE 1105
Query: 927 SPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQP-------------GGSGDSIPITA 973
+ S S AP S + Q G S D+ +A
Sbjct: 1106 PGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASA 1165
Query: 974 LVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLL 1033
++ + + ++ S VNVNP + P I Y+K F SEI C +LWGVNLL
Sbjct: 1166 ILYAGFVEVPE--ESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGSLWGVNLL 1223
Query: 1034 VGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK 1093
+GT + L L+DRSG+ + LI RR F+Q+ VLE LNLLITISG +N+LRVY+L+WLRNK
Sbjct: 1224 LGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWLRNK 1283
Query: 1094 ILHNDPEVEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAP 1145
IL+NDPE +++Q + + GC H+ V+++E ++ IALKSS+ +YAWAP
Sbjct: 1284 ILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAP 1343
Query: 1146 K---------------------------------------PYHKF---------MAFKSF 1157
K P ++F + K F
Sbjct: 1344 KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF 1403
Query: 1158 ADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIF 1217
L H+P+ VDL + +RLK+ + S+ G+H +D +S D+ +P + I P II
Sbjct: 1404 PTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNIII 1463
Query: 1218 LPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR 1277
LP+ G+ M+L + E + V ++ K ++ W ++P+S+A+ C+ + GWG+KAIE+R
Sbjct: 1464 LPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVR 1523
Query: 1278 SVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR 1326
S+++ L+ + ++L+FLC R DK+FF S S+VYFMTL +
Sbjct: 1524 SLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
Score = 42.7 bits (99), Expect = 0.002
Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 36/230 (15%)
Query: 351 LRREFLRLQQENKSNSEALKQQQQL-----------QQQQQRDPEAHIKHLLHQRQRRIE 399
L R+ LR N +NS+ L Q L Q +Q R+ ++ + L +R+
Sbjct: 643 LSRDLLRAP--NSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
Query: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ 459
++ + ++ E + + + +QRR ED+ + EEE RQ ++++E + +E
Sbjct: 701 PKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDI-FNQHEEELRQVDKDKEDESSDNDEV 759
Query: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG--------M 511
S + + Q++ Y+ + ++++ Q++ +P ++ +H +
Sbjct: 760 FHSIQAEVQIEPLKPYISN------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813
Query: 512 NPADKPAWAREVEERTRMN--------KQQNSPLAKSKPGSTGPEPPIPQ 553
A KP R+ + R N ++ SP+ + S+ P I Q
Sbjct: 814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQ 863
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 310 bits (793), Expect = 8e-84
Identities = 153/273 (56%), Positives = 189/273 (69%), Gaps = 4/273 (1%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN--TKGNALKEDCIAYICREI 137
N+ +YG + KK N D+LWLV+E C GSVTDLVK +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKV-NGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH +K IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVIAC++ D TYD R D WSLGITAIE+ +G PPL D+HPMRALF IPRNPPP+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
WS +F DFI CL K Y RP +LL+ FI
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 292 bits (747), Expect = 2e-78
Identities = 156/327 (47%), Positives = 206/327 (62%), Gaps = 11/327 (3%)
Query: 13 IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK--GNALKEDCI 130
L+ +H N+ +YG F K QLWLV+E C GSVT+LVK G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHCVGG-QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250
TP+WMAPEVIAC++ D++YD R D+WSLGITAIE+ +G PPL DMHP++ LF IPRNPP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP-----TERQVRIQLKD 304
P L +KW ++F FI CLIK + RP LL PFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRSRKKRGEKEETEYEYSGSEEE 329
H + K R E+ T Y + E
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAE 340
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 292 bits (747), Expect = 2e-78
Identities = 156/327 (47%), Positives = 206/327 (62%), Gaps = 11/327 (3%)
Query: 13 IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK--GNALKEDCI 130
L+ +H N+ +YG F K QLWLV+E C GSVT+LVK G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHCVGG-QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250
TP+WMAPEVIAC++ D++YD R D+WSLGITAIE+ +G PPL DMHP++ LF IPRNPP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP-----TERQVRIQLKD 304
P L +KW ++F FI CLIK + RP LL PFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRSRKKRGEKEETEYEYSGSEEE 329
H + K R E+ T Y + E
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAE 340
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 264 bits (675), Expect = 4e-70
Identities = 146/345 (42%), Positives = 214/345 (62%), Gaps = 20/345 (5%)
Query: 6 PARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
P R L +D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA 124
IK+ M + S H + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +DIWSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLK 303
IP NPPP K + WS F DF+ CL+K+ R QLL+ PF+R + + V I L+
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR---SAKGVSI-LR 291
Query: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGE 348
D I+ + + +++E++ ++E++S +E + +++ G+
Sbjct: 292 DLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 262 bits (669), Expect = 2e-69
Identities = 156/378 (41%), Positives = 223/378 (58%), Gaps = 39/378 (10%)
Query: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINML 73
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
Query: 74 KKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
Query: 134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
RE L+GL +LH+ +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
Query: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPP 251
WMAPEV A + Y+ D+W++GITAIE+AE PP+ D+HPMRALFL+ ++ PP
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
Query: 252 RLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR 310
+LK K KWS F F+ L K RP E+LL+ PF+ T R + I+L D ++
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT-RSLAIELLDKVNNP- 292
Query: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG--ESTLRREFLRLQQENKSNSEA 368
++S + DD +P ++ VP ST R +E K+ SE
Sbjct: 293 -----------DHSTYHDFDDD-----DPEPLVAVPHRIHSTSRN-----VREEKTRSEI 331
Query: 369 LKQQQQLQQQQQRDPEAH 386
Q + +++ E H
Sbjct: 332 TFGQVKFDPPLRKETEPH 349
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 257 bits (657), Expect = 5e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
Query: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
Query: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
Query: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
Query: 301 QLKDHID 307
+L D ++
Sbjct: 289 ELLDKVN 295
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 257 bits (657), Expect = 5e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
Query: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
Query: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
Query: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
Query: 301 QLKDHID 307
+L D ++
Sbjct: 289 ELLDKVN 295
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 256 bits (655), Expect = 8e-68
Identities = 145/329 (44%), Positives = 203/329 (61%), Gaps = 23/329 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
I Y+G+++K + +LW++ME+ G GS DL+K L+E IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ + IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD+++DIWSLGITAIE+A+G PP D+HPMR LFLIP+N PP L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
SK F +F++ CL K RP ++LLK FI + +L D R KR + E
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSE 293
Query: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVP 346
E S + + D E+GE I P
Sbjct: 294 GHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 256 bits (653), Expect = 1e-67
Identities = 143/334 (42%), Positives = 204/334 (61%), Gaps = 18/334 (5%)
Query: 4 PAPARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE 62
PAP L + +L + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 5 PAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL 64
Query: 63 EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG 122
+E IK EI+++++ + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 65 QEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRN 115
Query: 123 NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 175
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRAL 242
+RNT IGTP+WMAPEVI + Y+ +DIWSLGIT+IEMAEG PP D+HPMRA+
Sbjct: 176 AKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAI 230
Query: 243 FLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
F+IP NPPP K + WS F DF+ CL+K R QLL+ PFI++ +R
Sbjct: 231 FMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
Query: 302 LKD--HIDRSRKKRGEKEETEYEYSGSEEEDDSH 333
+ + I R + ++E E E + E+E DSH
Sbjct: 291 ITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 253 bits (646), Expect = 9e-67
Identities = 150/383 (39%), Positives = 226/383 (59%), Gaps = 39/383 (10%)
Query: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
Query: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
Query: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
Query: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS 255
APEVI + YD ++DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
Query: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
++K F +FID CL K RP ++LLK FI + +L D R + +
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 316 KEETEYEYSGSE---EEDDSHGE--------EGEPSSIMNVPGESTLRR----------E 354
+E++ E S SE E+++H E + +P + N + ++
Sbjct: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
Query: 355 FLRLQQENKSNSEALKQQQQLQQ 377
F L+Q++++N+ + ++L++
Sbjct: 361 FAELKQQDENNASRNQAIEELEK 383
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 249 bits (637), Expect = 1e-65
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 242
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 299
Query: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
+ S+ E D G S
Sbjct: 300 HDDSSSEDSDAETDGQASGGSDS 322
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 249 bits (637), Expect = 1e-65
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 201 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 254
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 311
Query: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
+ S+ E D G S
Sbjct: 312 HDDSSSEDSDAETDGQASGGSDS 334
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 243 bits (621), Expect = 7e-64
Identities = 139/326 (42%), Positives = 196/326 (60%), Gaps = 17/326 (5%)
Query: 17 ALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKK 75
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++QEI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH+ IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKK 312
+ K +W++ F F+ L K RP E+LL+ PF Q R + QL D
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
Query: 313 RGEKEETEYE-YSGSEEEDDSHGEEG 337
E+ E E Y + S G+ G
Sbjct: 296 TPSPEDCELETYDMFPDTIHSRGQHG 321
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 242 bits (618), Expect = 2e-63
Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)
Query: 19 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
Query: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
Query: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
+GLA+LH+ K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256
V A Y+ DIWSLGITAIE+AE PPL D+HP+R LFL+ ++ PPRLK K
Sbjct: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
Query: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314
KWS F +FI L K+ RP ++L + R + + L D + K
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
Query: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366
E EE E + +H SS + +P RR EF +L + +N+
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
Query: 367 EALKQQQQLQQQQQR 381
L+ + L+ R
Sbjct: 356 ARLQPPRDLRSSSPR 370
Score = 33.1 bits (74), Expect = 1.8
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 1031 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1090
+LL+G E G+ +L+R+ Q ++ R + + N+L+++SGK L + + L
Sbjct: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
Query: 1091 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1137
N I H P K T + D +GC V + FL AL++S
Sbjct: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
Query: 1138 VEVYAWAPKPYHKFM 1152
V + W +P +KF+
Sbjct: 631 VVLLQWY-QPMNKFL 644
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,248,453
Number of Sequences: 37866
Number of extensions: 3807617
Number of successful extensions: 87805
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1680
Number of HSP's successfully gapped in prelim test: 2628
Number of HSP's that attempted gapping in prelim test: 22236
Number of HSP's gapped (non-prelim): 27124
length of query: 1332
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1218
effective length of database: 13,930,794
effective search space: 16967707092
effective search space used: 16967707092
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.