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Search of human proteins with 25952152
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
(433 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 876 0.0
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 838 0.0
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 276 3e-74
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 273 2e-73
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 269 4e-72
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 268 7e-72
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 265 8e-71
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 259 3e-69
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 251 7e-67
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 246 2e-65
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 238 1e-62
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 229 5e-60
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 219 3e-57
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 212 6e-55
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 189 3e-48
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 138 1e-32
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 135 9e-32
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 133 3e-31
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 125 1e-28
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 125 1e-28
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 125 1e-28
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 118 9e-27
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 118 9e-27
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 117 2e-26
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 117 2e-26
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 109 4e-24
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 109 4e-24
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 108 7e-24
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 99 6e-21
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 99 6e-21
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 876 bits (2264), Expect = 0.0
Identities = 433/433 (100%), Positives = 433/433 (100%)
Query: 1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS 60
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS
Sbjct: 1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS 60
Query: 61 WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS 120
WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS
Sbjct: 61 WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS 120
Query: 121 SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180
SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS
Sbjct: 121 SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180
Query: 181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT 240
ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT
Sbjct: 181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT 240
Query: 241 QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYVKRALAEGAQIWC 300
QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYVKRALAEGAQIWC
Sbjct: 241 QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYVKRALAEGAQIWC 300
Query: 301 GEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANN 360
GEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANN
Sbjct: 301 GEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANN 360
Query: 361 VKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSY 420
VKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSY
Sbjct: 361 VKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSY 420
Query: 421 DFFTEIKTITVKH 433
DFFTEIKTITVKH
Sbjct: 421 DFFTEIKTITVKH 433
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 838 bits (2166), Expect = 0.0
Identities = 428/487 (87%), Positives = 430/487 (88%), Gaps = 54/487 (11%)
Query: 1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS 60
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS
Sbjct: 1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS 60
Query: 61 WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS 120
WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS
Sbjct: 61 WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS 120
Query: 121 SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180
SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS
Sbjct: 121 SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180
Query: 181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT 240
ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT
Sbjct: 181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT 240
Query: 241 QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQ----------------V 284
QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQ
Sbjct: 241 QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY 300
Query: 285 RSYVKR--------------------------------------ALAEGAQIWCGEGVDK 306
++KR ALAEGAQIWCGEGVDK
Sbjct: 301 SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK 360
Query: 307 LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA 366
LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA
Sbjct: 361 LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA 420
Query: 367 ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI 426
ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI
Sbjct: 421 ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI 480
Query: 427 KTITVKH 433
KTITVKH
Sbjct: 481 KTITVKH 487
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 276 bits (705), Expect = 3e-74
Identities = 158/460 (34%), Positives = 251/460 (54%), Gaps = 58/460 (12%)
Query: 27 SYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEE 86
+++P+TG V SG+ E+ AV+ A+ AF WS +S ER R+L + A ++ + +E
Sbjct: 55 AFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDE 114
Query: 87 FAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVG 146
A E + GK++ AR +DI S Q ++A + E Q+ G YT R P+G
Sbjct: 115 IATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPG-GSFGYTRREPLG 172
Query: 147 VAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNI 206
V I WN P + +WK APA+A GN ++ KPS T V+A +L ++ +AGVPPG+ N+
Sbjct: 173 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNV 232
Query: 207 VFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDA 266
V G G G+ L HP+V +SFTGS PT +I ++SA K ++LELGGK+P IIF D
Sbjct: 233 VQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDC 291
Query: 267 NLDECIPATVRSSF-------ANQVRSYVKR----------------------------- 290
+++ + + ++F N R +V++
Sbjct: 292 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 351
Query: 291 ------------------ALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESC 332
A +GA++ CG + P + + GY+M P V+T+ +D+
Sbjct: 352 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP-KLKDGYYMRPCVLTNCRDDMT 410
Query: 333 CMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTN 392
C+ EEIFGPV ++ FD+E EV+ERAN+ +GLAA V++ ++ R HRV +LQ+G + N
Sbjct: 411 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 470
Query: 393 CWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
+ + + LPFGG K SG GRE + + ++++++KT+ V+
Sbjct: 471 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 510
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 273 bits (698), Expect = 2e-73
Identities = 165/463 (35%), Positives = 245/463 (52%), Gaps = 68/463 (14%)
Query: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFP---SWSSRSPQERSRVLNQVADLLEQSLE 85
+PSTGEV C+V K++++ AVKAAR AF W R R+LN++ADL+E+
Sbjct: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117
Query: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
A E+ D GK ++ +D+ ++ R++A + + + +D YT PV
Sbjct: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDG-DFFSYTRHEPV 176
Query: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
GV G I PWN PL + WK+ PA+A GN V+ K +E T +TA + L+ +AG PPGVVN
Sbjct: 177 GVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVN 236
Query: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA--PHCKKLSLELGGKNPAIIF 263
IV G GP G A+ SH +V ++FTGS R+ Q++A + K+++LELGGK+P II
Sbjct: 237 IVPGFGPTAGAAIASHEDVDKVAFTGSTEIG-RVIQVAAGSSNLKRVTLELGGKSPNIIM 295
Query: 264 EDANLDECIPATVRSSFANQVR----------------SYVKRALA-------------- 293
DA++D + + F NQ + +V+R++A
Sbjct: 296 SDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSK 355
Query: 294 ------------------------EGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKD 329
EGA++ CG G+ GYF+ PTV D++D
Sbjct: 356 TEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGI-------AADRGYFIQPTVFGDVQD 408
Query: 330 ESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLV 389
EEIFGPV ++ F + EEV+ RANN YGLAA V++ ++ + + +++ LQ+G V
Sbjct: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
Query: 390 WTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
W NC+ + PFGG K SG GRE + +TE+KT+TVK
Sbjct: 469 WVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 269 bits (687), Expect = 4e-72
Identities = 166/462 (35%), Positives = 240/462 (51%), Gaps = 66/462 (14%)
Query: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSLE 85
+PST E C V K +++ AV+AA+ AF W R R+L+Q+ADL+E+
Sbjct: 53 NPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRA 112
Query: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
A E+ D GK A +D+ ++ R+FA + + D + +T P+
Sbjct: 113 TLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDD-NVVCFTRHEPI 171
Query: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
GV G I+PWN PL +L WK+APA+ GNT++ KP+E T +TA L L+ +AG PPGVVN
Sbjct: 172 GVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVN 231
Query: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQ-LSAPHCKKLSLELGGKNPAIIFE 264
IV G GP VG A+ SHP++ I+FTGS + + + S + K+++LELGGKNP I+
Sbjct: 232 IVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCA 291
Query: 265 DANLD---------------ECIPATVRSSFANQVRS-YVKRAL---------------- 292
DA+LD +C A R QV S +V+R++
Sbjct: 292 DADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKT 351
Query: 293 ----------------------AEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDE 330
EGA++ CG A G F+ PTV +++ D
Sbjct: 352 EQGPQIDQKQFDKILELIESGKKEGAKLECGGS-------AMEDKGLFIKPTVFSEVTDN 404
Query: 331 SCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVW 390
EEIFGPV ++ F S EEVI+RAN+ YGL A V++ N+ + ++A L+SG VW
Sbjct: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
Query: 391 TNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
NC+ PFGG K SG GRE + + +TE+KT+T+K
Sbjct: 465 INCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 268 bits (685), Expect = 7e-72
Identities = 164/463 (35%), Positives = 243/463 (52%), Gaps = 66/463 (14%)
Query: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFP---SWSSRSPQERSRVLNQVADLLEQSL 84
++P+T E C+V K++++ AVKAAR+AF W + ER R+L ++ADL+E+
Sbjct: 41 FNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100
Query: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAP 144
A ES + GK + A D+ ++ R+ A + +D YT P
Sbjct: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDG-NFFTYTRHEP 159
Query: 145 VGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVV 204
+GV G I PWN PL +L WKI PA++ GNTV+ KP+E T +TA + L+ +AG PPGVV
Sbjct: 160 IGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVV 219
Query: 205 NIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAIIF 263
NIV G GP G A+ SH ++ ++FTGS + I + + + K+++LELGGK+P I+
Sbjct: 220 NIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVL 279
Query: 264 EDANLDECIPATVRSSFANQ--------------------VRSYVKRA------------ 291
DA+LD + F +Q VR V+RA
Sbjct: 280 ADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPG 339
Query: 292 ----------------------LAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKD 329
EGA++ CG G P N+ GYF+ PTV +++ D
Sbjct: 340 VTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGNK-GYFVQPTVFSNVTD 392
Query: 330 ESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLV 389
E EEIFGPV ++ F S ++VI+RANN YGL+A V++ ++ + ++ LQ+G V
Sbjct: 393 EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTV 452
Query: 390 WTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
W NC+ + PFGG K SG GRE + + +TE+KT+TVK
Sbjct: 453 WVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 265 bits (676), Expect = 8e-71
Identities = 163/465 (35%), Positives = 244/465 (52%), Gaps = 70/465 (15%)
Query: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSL 84
Y+P+TGE C V + K +I+ AV+AAR AF W ER R+L+++ADL+E+
Sbjct: 58 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 117
Query: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHTSECTQMDHLGCMHYTVR 142
A ES + GK A +D+ ++ FR++A + +H + D+ +T
Sbjct: 118 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFT---FTRH 174
Query: 143 APVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202
P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T ++A + L+ +AG PPG
Sbjct: 175 EPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPG 234
Query: 203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAI 261
V+NI+ G GP G A+ SH + I+FTGS + I + + + K+++LELGGK+P I
Sbjct: 235 VINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNI 294
Query: 262 IFEDANLDECIPATVRSSFANQ--------------------VRSYVKRA---------- 291
IF DA+LD + + F NQ VR V+RA
Sbjct: 295 IFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFD 354
Query: 292 ------------------------LAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDI 327
+AEGA++ CG + G+F+ PTV +++
Sbjct: 355 PTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------KGLGRKGFFIEPTVFSNV 407
Query: 328 KDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSG 387
D+ EEIFGPV ++ F + +EVIERANN +GL A V+++++ + V+ +Q+G
Sbjct: 408 TDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAG 467
Query: 388 LVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
VW NC+ PFGG K SG GRE + ++E+KT+TVK
Sbjct: 468 TVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 259 bits (663), Expect = 3e-69
Identities = 157/462 (33%), Positives = 237/462 (51%), Gaps = 66/462 (14%)
Query: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAF---PSWSSRSPQERSRVLNQVADLLEQSLE 85
+P+TGEV V + +++ AVKAAREAF W ER R+LN++ADL+E+
Sbjct: 58 NPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRV 117
Query: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
A E+ D GK + +D+ ++ +R+FA + + MD +T PV
Sbjct: 118 YLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFC-FTRHEPV 176
Query: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
GV G I PWN PL + WK+APA+A GNTV+ K +E T ++A L L+ +AG PPGVVN
Sbjct: 177 GVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN 236
Query: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAIIFE 264
I+ G GP G A+ H +V ++FTGS I + + + K+++LELGGK+P+I+
Sbjct: 237 IITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLA 296
Query: 265 DANLDECIPATVRSSFANQ-------VRSYVKRAL------------------------- 292
DA+++ + + F N R++V+ ++
Sbjct: 297 DADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDT 356
Query: 293 ----------------------AEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDE 330
EGA++ CG + G+F+ PTV ++D+
Sbjct: 357 QQGPQVDKEQFERVLGYIQLGQKEGAKLLCGG-------ERFGERGFFIKPTVFGGVQDD 409
Query: 331 SCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVW 390
EEIFGPV + F EEV+ERANN +YGLAA V++ ++ + + LQ+G VW
Sbjct: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
Query: 391 TNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
N + I + PFGG K SG GRE +D +TE+KT+T+K
Sbjct: 470 VNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 511
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 251 bits (642), Expect = 7e-67
Identities = 154/478 (32%), Positives = 258/478 (53%), Gaps = 57/478 (11%)
Query: 13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS--WSSRSPQE 68
FI+G+F D+ +P+ G C+V + +++ AV AA++AF + W + +E
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
Query: 69 RSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFAS---SSLHHT 125
R R++ ++ADLLE++ EE A E+ D G LA I SVQ FR+FA T
Sbjct: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Q + +T + P+GV +I PWN PL +L WK A +AAGNT++ KP+++T +
Sbjct: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
Query: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
TA +L KAG P GV+NI+ G+G G+ L HP++ + FTGS P ++I + A
Sbjct: 626 TALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAV 685
Query: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRS----------------YV 288
+ KK+SLELGGK+P IIF D LD+ + + + F N+ + +V
Sbjct: 686 SNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFV 745
Query: 289 KRALAEGAQIWCGEGVDKLS--LPARNQA-----------------------------GY 317
R + E ++ G+ +D+ + P ++A G+
Sbjct: 746 TRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGF 805
Query: 318 FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSE--EEVIERANNVKYGLAATVWSSNVG 375
FM PTV TD++D EE FGP+ + F + + V++RAN+ +YGLA+ V++ ++
Sbjct: 806 FMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDIN 865
Query: 376 RVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH 433
+ V++KL++G V+ N + ++ PFGG+K SG G++ +++ + + + KT+T+++
Sbjct: 866 KAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY 923
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 246 bits (629), Expect = 2e-65
Identities = 158/478 (33%), Positives = 254/478 (53%), Gaps = 57/478 (11%)
Query: 13 FIDGKFLPC--SSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS--WSSRSPQE 68
FI G+F+ + ++ +P+ G V C+V + +++ AV AA++AF + W S ++
Sbjct: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
Query: 69 RSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFAS---SSLHHT 125
R R++ ++ADL+EQ EE A E+ D G LA + S+Q FR+FA T
Sbjct: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Q + T + PVGV G+I PWN PL +L+WK A +AAGNTV+ KP+++T +
Sbjct: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 604
Query: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
TA +L KAG+P GVVN++ G+G VG+ L HP+V I FTGS + I + A
Sbjct: 605 TALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAI 664
Query: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRS----------------YV 288
+ KK+SLELGGK+P IIF D +L++ + + S F N+ + +V
Sbjct: 665 SNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFV 724
Query: 289 KRALAEGAQIWCGEGVDKLS--LPARNQA-----------------------------GY 317
+R + E ++ G +D+ + P + A G+
Sbjct: 725 RRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGF 784
Query: 318 FMLPTVITDIKDESCCMTEEIFGPVTCVVPF-DSE-EEVIERANNVKYGLAATVWSSNVG 375
F PTV TD++D EE FGPV + F D + + V+ RAN ++GLA+ V++ ++
Sbjct: 785 FFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDIN 844
Query: 376 RVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH 433
+ V+ KLQ+G V+ N + ++ PFGG K SG G++ + + + + +KT+T ++
Sbjct: 845 KALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY 902
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 238 bits (606), Expect = 1e-62
Identities = 146/422 (34%), Positives = 221/422 (52%), Gaps = 67/422 (15%)
Query: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHT 125
ER R+L+++ADL+E+ A ES + GK A +D+ ++ FR++A + +H
Sbjct: 5 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 64
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
+ D+ +T P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T +
Sbjct: 65 TIPVDGDYFT---FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPL 121
Query: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
+A + L+ +AG PPGV+NI+ G GP G A+ SH + I+FTGS + I + +
Sbjct: 122 SALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGR 181
Query: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQ--------------------V 284
+ K+++LELGGK+P IIF DA+LD + + F NQ V
Sbjct: 182 SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFV 241
Query: 285 RSYVKRA----------------------------------LAEGAQIWCGEGVDKLSLP 310
R V+RA +AEGA++ CG
Sbjct: 242 RRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------K 294
Query: 311 ARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVW 370
+ G+F+ PTV +++ D+ EEIFGPV ++ F + +EVIERANN +GL A V+
Sbjct: 295 GLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVF 354
Query: 371 SSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTIT 430
++++ + V+ +Q+G VW NC+ PFGG K SG GRE + ++E+KT+T
Sbjct: 355 TNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 414
Query: 431 VK 432
VK
Sbjct: 415 VK 416
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 229 bits (583), Expect = 5e-60
Identities = 153/475 (32%), Positives = 242/475 (50%), Gaps = 52/475 (10%)
Query: 6 ALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRS 65
ALL ++F+ G++LP ++ DP++G V + G E AAV+AA EAF W S
Sbjct: 57 ALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116
Query: 66 PQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT 125
+ERS +L + +L+ Q+ ++ A+ + + GK L A +I S +F+ +
Sbjct: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
+ ++ P+GVA +I+PWN P ++T K+ A+AAG TV+ KP+E T
Sbjct: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
Query: 186 TAWMLCKLLDKAGVPPGVVNIV---FGTGPRVGEALVSHPEVPLISFTGSQPTAERITQL 242
+A L +L +AG+P GV N++ VGEA+ + P V ISFTGS T + +
Sbjct: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295
Query: 243 SAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYV-------------- 288
+A K++S+ELGG P I+F+ AN+D+ + + S F N ++ V
Sbjct: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355
Query: 289 -KRALAEGAQ--IWCGEG---------------VDKLSLPA---------------RNQA 315
+A AE + + G G V+K+ R+Q
Sbjct: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 415
Query: 316 G-YFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNV 374
G F PT++ ++ + C EE FGP+ V+ FD+EEE I AN GLA +S +
Sbjct: 416 GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDP 475
Query: 375 GRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTI 429
++ RVA++L+ G+V N LI + PFGG+K SG+GREG+K D + E+K +
Sbjct: 476 AQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 219 bits (559), Expect = 3e-57
Identities = 153/488 (31%), Positives = 242/488 (49%), Gaps = 65/488 (13%)
Query: 6 ALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRS 65
ALL ++F+ G++LP ++ DP++G V + G E AAV+AA EAF W S
Sbjct: 57 ALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116
Query: 66 PQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT 125
+ERS +L + +L+ Q+ ++ A+ + + GK L A +I S +F+ +
Sbjct: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
+ ++ P+GVA +I+PWN P ++T K+ A+AAG TV+ KP+E T
Sbjct: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
Query: 186 TAWMLCK-------------LLDKAGVPPGVVNIV---FGTGPRVGEALVSHPEVPLISF 229
+A L + L +AG+P GV N++ VGEA+ + P V ISF
Sbjct: 236 SALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 295
Query: 230 TGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYV- 288
TGS T + + +A K++S+ELGG P I+F+ AN+D+ + + S F N ++ V
Sbjct: 296 TGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVC 355
Query: 289 --------------KRALAEGAQ--IWCGEG---------------VDKLSLPA------ 311
+A AE + + G G V+K+
Sbjct: 356 SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSK 415
Query: 312 ---------RNQAG-YFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNV 361
R+Q G F PT++ ++ + C EE FGP+ V+ FD+EEE I AN
Sbjct: 416 GATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAA 475
Query: 362 KYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYD 421
GLA +S + ++ RVA++L+ G+V N LI + PFGG+K SG+GREG+K D
Sbjct: 476 DVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGID 535
Query: 422 FFTEIKTI 429
+ E+K +
Sbjct: 536 EYLELKYV 543
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 212 bits (539), Expect = 6e-55
Identities = 146/464 (31%), Positives = 218/464 (46%), Gaps = 106/464 (22%)
Query: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSL 84
Y+P+TGE C V + K +I+ AV+AAR AF W ER R+L+++ADL+E+
Sbjct: 58 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 117
Query: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHTSECTQMDHLGCMHYTVR 142
A ES + GK A +D+ ++ FR++A + +H + D+ +T
Sbjct: 118 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFT---FTRH 174
Query: 143 APVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202
P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T ++A + L+ + G
Sbjct: 175 EPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG---- 230
Query: 203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAII 262
LI + +R+T LELGGK+P II
Sbjct: 231 ----------------------KLIQEAAGRSNLKRVT-----------LELGGKSPNII 257
Query: 263 FEDANLDECIPATVRSSFANQ--------------------VRSYVKRA----------- 291
F DA+LD + + F NQ VR V+RA
Sbjct: 258 FADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDP 317
Query: 292 -----------------------LAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIK 328
+AEGA++ CG + G+F+ PTV +++
Sbjct: 318 TTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------KGLGRKGFFIEPTVFSNVT 370
Query: 329 DESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGL 388
D+ EEIFGPV ++ F + +EVIERANN +GL A V+++++ + V+ +Q+G
Sbjct: 371 DDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGT 430
Query: 389 VWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
VW NC+ PFGG K SG GRE + ++E+KT+TVK
Sbjct: 431 VWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 189 bits (481), Expect = 3e-48
Identities = 142/473 (30%), Positives = 220/473 (46%), Gaps = 57/473 (12%)
Query: 13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS 70
FI GKF+ S +ID ++P+T EV RVP + K E++AA+ + + AFP+W+ S R
Sbjct: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQ 102
Query: 71 RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQ 130
+VL + L++++L+E A+ + +QGKTLA A D+ R +Q S + E
Sbjct: 103 QVLLRYQQLIKENLKEIAKLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMP 161
Query: 131 MDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWML 190
Y+ R P+GV I+P+N P + W AM GNT + KPSE +L
Sbjct: 162 SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLL 221
Query: 191 CKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKL 250
KLL +G P G +NI+ G V + HP++ ISF GS E I + + H K++
Sbjct: 222 AKLLQDSGAPDGTLNIIHGQHEAV-NFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRV 280
Query: 251 SLELGGKNPAIIFEDANLDECIPATVRSSF--ANQVRSYVKRALAEG-AQIWCGEGVD-- 305
+G KN ++ DAN + + V ++F A Q + A+ G A+ W E V+
Sbjct: 281 QANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHA 340
Query: 306 -KLSLPARNQA--------------------------------------------GYFML 320
L + A +Q G F+
Sbjct: 341 KNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVG 400
Query: 321 PTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRV 380
PT+I+++K C EEIFGPV V+ ++ +E I+ NN YG ++++N +
Sbjct: 401 PTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKY 460
Query: 381 AKKLQSGLVWTNCWLIRELNL-PFGGMKSSGIGREG--AKDSYDFFTEIKTIT 430
A + G V N + L + F G +SS G K F+T++KTIT
Sbjct: 461 AHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 138 bits (347), Expect = 1e-32
Identities = 115/453 (25%), Positives = 205/453 (45%), Gaps = 57/453 (12%)
Query: 10 LENFIDGKFLPCS--SYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQ 67
L ++++GK+L + + DP TGE + +++ AAV+AAR AF WS+
Sbjct: 40 LGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGV 99
Query: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSE 127
R++ L ++A+++++ ES G+ + R D+ + Q + H
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY------HAIQA 153
Query: 128 CTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTA 187
TQ + L P+GV GLI P + W+I PA+A G TV+A S
Sbjct: 154 STQEEALAGWE-----PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPP-ASPAP 207
Query: 188 WMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHC 247
+L +L + G PG++N++ G V L S P + ++F G+ + + A C
Sbjct: 208 LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLAGEC 266
Query: 248 KKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQ----VRSYVKRALAEGA------- 296
+L L LG ++ ++ + A++D + V ++++++ +R ++ ++ + A
Sbjct: 267 AELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQER 326
Query: 297 --QIWCGEGVD-KLSLPARN----------------------QAG------YFMLPTVIT 325
++ G G+D + + AR QAG F PT+++
Sbjct: 327 MGRLRSGRGLDGAVDMGARGAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVS 386
Query: 326 DIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQ 385
++ S C E+ PV PF + +E + AN G +A+VWS +G+ + LQ
Sbjct: 387 NLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQ 446
Query: 386 SGLVWTNCWLIRELNLPFGGMKSSGIGREGAKD 418
G VW N +R+ ++P GG K SG G D
Sbjct: 447 VGTVWINAHGLRDPSVPTGGCKESGCSWHGGPD 479
Score = 83.6 bits (205), Expect = 3e-16
Identities = 68/238 (28%), Positives = 112/238 (47%), Gaps = 7/238 (2%)
Query: 13 FIDGKF-LPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSR 71
F+ G+F P + S+G ++ V G +I AV+AA +AFP W+ +SP R+
Sbjct: 531 FVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAA 590
Query: 72 VLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQM 131
+L +A LE+ A + + QG L A ++ S + R + + + Q+
Sbjct: 591 LLWALAAALERRKSTLA-SRLERQGAELKAAEA-EVELSARRLRAW-GARVQAQGHTLQV 647
Query: 132 DHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLC 191
L +R P+GV ++ P PL +APA+A GNTV+ PS + A +C
Sbjct: 648 AGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVC 707
Query: 192 KLLDKAGV-PPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCK 248
+ D A V P G+ N+V G + L H +V + + GS ++ + SA + K
Sbjct: 708 Q--DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLK 763
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 135 bits (339), Expect = 9e-32
Identities = 115/485 (23%), Positives = 203/485 (41%), Gaps = 72/485 (14%)
Query: 11 ENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS 70
E +G + I +Y P+ E RV + + E VK AREA+ W+ +R
Sbjct: 52 EGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRG 111
Query: 71 RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQ 130
++ Q+ D L + ++ S + GK L + ++ V + S
Sbjct: 112 EIVRQIGDALREKIQVLGSLVSLEMGKIL-VEGVGEVQEYVDICDYAVGLSRMIGGPILP 170
Query: 131 MDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAW-- 188
+ G PVG+ G+I+ +N P+ + W A AM GN + K + TS+ +
Sbjct: 171 SERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAV 230
Query: 189 --MLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPH 246
++ K+L+ +P + ++ G G +G A+ V L+SFTGS +++ +
Sbjct: 231 TKIIAKVLEDNKLPGAICSLTCG-GADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
Query: 247 CKKLSLELGGKNPAIIFEDANLDECIPAT-------------------VRSSFANQVRSY 287
+ LELGG N I FEDA+L +P+ + S ++V +
Sbjct: 290 FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNR 349
Query: 288 VKRALAE------------------------------------GAQIWCGEGVDKLSLPA 311
+K+A A+ G ++ G+ +D+
Sbjct: 350 LKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDR----- 404
Query: 312 RNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWS 371
G ++ PT++T + ++ E F P+ V F +EEEV N VK GL++++++
Sbjct: 405 ---PGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFT 461
Query: 372 SNVGRVHR--VAKKLQSGLVWTNCWLI-RELNLPFGGMKSSGIGREGAKDSYDFFTEIKT 428
++GR+ R K G+V N E+ FGG K +G GRE D++ + T
Sbjct: 462 KDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRST 521
Query: 429 ITVKH 433
T+ +
Sbjct: 522 CTINY 526
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 133 bits (335), Expect = 3e-31
Identities = 111/415 (26%), Positives = 190/415 (45%), Gaps = 32/415 (7%)
Query: 10 LENFIDGKFLPCS--SYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQ 67
L ++++GK+L + + DP TGE + +++ AAV+AAR AF WS+
Sbjct: 40 LGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGV 99
Query: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSE 127
R++ L ++A+++++ ES G+ + R D+ + Q + H
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY------HAIQA 153
Query: 128 CTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTA 187
TQ + L P+GV GLI P + W+I PA+A G TV+A S
Sbjct: 154 STQEEALAGWE-----PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPP-ASPAP 207
Query: 188 WMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA--- 244
+L +L + G PG++N++ G V L S P + ++F G+ R+ +
Sbjct: 208 LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVWD 266
Query: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFA-NQVRSYVKRALAEGAQIWCGEG 303
++L +G + LD + R + A + V+ +V+ A ++GAQ++
Sbjct: 267 EAMRRLQERMGR-----LRSGRGLDGAVDMGARGAAACDLVQRFVREAQSQGAQVFQAGD 321
Query: 304 VDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKY 363
V P+ F PT+++++ S C E+ PV PF + +E + AN
Sbjct: 322 V-----PSERP---FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPR 373
Query: 364 GLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKD 418
G +A+VWS +G+ + LQ G VW N +R+ ++P GG K SG G D
Sbjct: 374 GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPD 428
Score = 83.6 bits (205), Expect = 3e-16
Identities = 68/238 (28%), Positives = 112/238 (47%), Gaps = 7/238 (2%)
Query: 13 FIDGKF-LPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSR 71
F+ G+F P + S+G ++ V G +I AV+AA +AFP W+ +SP R+
Sbjct: 480 FVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAA 539
Query: 72 VLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQM 131
+L +A LE+ A + + QG L A ++ S + R + + + Q+
Sbjct: 540 LLWALAAALERRKSTLA-SRLERQGAELKAAEA-EVELSARRLRAW-GARVQAQGHTLQV 596
Query: 132 DHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLC 191
L +R P+GV ++ P PL +APA+A GNTV+ PS + A +C
Sbjct: 597 AGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVC 656
Query: 192 KLLDKAGV-PPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCK 248
+ D A V P G+ N+V G + L H +V + + GS ++ + SA + K
Sbjct: 657 Q--DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLK 712
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 125 bits (313), Expect = 1e-28
Identities = 120/440 (27%), Positives = 193/440 (43%), Gaps = 64/440 (14%)
Query: 46 EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103
+I AVK AR AF S +R Q R + L + L+++ +E A + D K A
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158
+I +Q +A+ + TQ D L Y P+GV +I WN P
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
Query: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214
L + A+AAGN+V+ KPSEL+ S+ A ++ + LDK P ++ G P
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
Query: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274
E L I +TGS + I +A H ++LELGGK+P + ++ +LD
Sbjct: 174 TELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
Query: 275 TVRSSFAN---------------QVRSYVKRALAEGAQIWCGEGVDK------------- 306
F N +++ + L + + + GE K
Sbjct: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHF 291
Query: 307 ---LSLPARNQAGY---------FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEV 354
+ L + Y ++ PT++TD+ +S M EEIFGPV +V S EE
Sbjct: 292 QRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 355 IERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL--NLPFGGMKSSGIG 412
I+ N + LA ++SSN + ++ + SG V N ++ +LPFGG+ +SG+G
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
Query: 413 REGAKDSYDFFTEIKTITVK 432
K S++ F+ ++ V+
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 125 bits (313), Expect = 1e-28
Identities = 120/440 (27%), Positives = 193/440 (43%), Gaps = 64/440 (14%)
Query: 46 EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103
+I AVK AR AF S +R Q R + L + L+++ +E A + D K A
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158
+I +Q +A+ + TQ D L Y P+GV +I WN P
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
Query: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214
L + A+AAGN+V+ KPSEL+ S+ A ++ + LDK P ++ G P
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
Query: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274
E L I +TGS + I +A H ++LELGGK+P + ++ +LD
Sbjct: 174 TELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
Query: 275 TVRSSFAN---------------QVRSYVKRALAEGAQIWCGEGVDK------------- 306
F N +++ + L + + + GE K
Sbjct: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHF 291
Query: 307 ---LSLPARNQAGY---------FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEV 354
+ L + Y ++ PT++TD+ +S M EEIFGPV +V S EE
Sbjct: 292 QRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 355 IERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL--NLPFGGMKSSGIG 412
I+ N + LA ++SSN + ++ + SG V N ++ +LPFGG+ +SG+G
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
Query: 413 REGAKDSYDFFTEIKTITVK 432
K S++ F+ ++ V+
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 125 bits (313), Expect = 1e-28
Identities = 120/440 (27%), Positives = 193/440 (43%), Gaps = 64/440 (14%)
Query: 46 EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103
+I AVK AR AF S +R Q R + L + L+++ +E A + D K A
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158
+I +Q +A+ + TQ D L Y P+GV +I WN P
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
Query: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214
L + A+AAGN+V+ KPSEL+ S+ A ++ + LDK P ++ G P
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
Query: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274
E L I +TGS + I +A H ++LELGGK+P + ++ +LD
Sbjct: 174 TELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
Query: 275 TVRSSFAN---------------QVRSYVKRALAEGAQIWCGEGVDK------------- 306
F N +++ + L + + + GE K
Sbjct: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHF 291
Query: 307 ---LSLPARNQAGY---------FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEV 354
+ L + Y ++ PT++TD+ +S M EEIFGPV +V S EE
Sbjct: 292 QRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 355 IERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL--NLPFGGMKSSGIG 412
I+ N + LA ++SSN + ++ + SG V N ++ +LPFGG+ +SG+G
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
Query: 413 REGAKDSYDFFTEIKTITVK 432
K S++ F+ ++ V+
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 118 bits (296), Expect = 9e-27
Identities = 118/439 (26%), Positives = 195/439 (44%), Gaps = 64/439 (14%)
Query: 47 IEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTL------- 99
+E V+ R+AF S SR + R + L + ++++ ++ A + D K+
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
Query: 100 ALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLY 159
+ +I ++N + ++ + T +D Y P+GV +I WN P
Sbjct: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA----YIQPQPLGVVLIIGAWNYPFV 116
Query: 160 LLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALV 219
L + A+AAGN VI KPSEL+ TA +L KLL + + + ++ G E L
Sbjct: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL- 174
Query: 220 SHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLD---------- 269
I +TG+ + + + +A H ++LELGGK+P I +D +LD
Sbjct: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233
Query: 270 ------ECIP---ATVRSSFANQVRSYVKRALAEGAQIWCGEGVDK-------------- 306
CI +S NQ+ +K + E + GE + +
Sbjct: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE----FYGENIKESPDYERIINLRHFK 289
Query: 307 --LSL---------PARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVI 355
LSL ++A ++ PTV+TD+ ++ M EEIFGP+ +VP + +E I
Sbjct: 290 RILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAI 349
Query: 356 ERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIR-ELN-LPFGGMKSSGIGR 413
N + LA V+S N + R+ + SG V N ++ LN PFGG+ SSG+G
Sbjct: 350 NFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA 409
Query: 414 EGAKDSYDFFTEIKTITVK 432
K S+D F+ + +K
Sbjct: 410 YHGKHSFDTFSHQRPCLLK 428
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 118 bits (296), Expect = 9e-27
Identities = 118/439 (26%), Positives = 195/439 (44%), Gaps = 64/439 (14%)
Query: 47 IEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTL------- 99
+E V+ R+AF S SR + R + L + ++++ ++ A + D K+
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
Query: 100 ALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLY 159
+ +I ++N + ++ + T +D Y P+GV +I WN P
Sbjct: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA----YIQPQPLGVVLIIGAWNYPFV 116
Query: 160 LLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALV 219
L + A+AAGN VI KPSEL+ TA +L KLL + + + ++ G E L
Sbjct: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL- 174
Query: 220 SHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLD---------- 269
I +TG+ + + + +A H ++LELGGK+P I +D +LD
Sbjct: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233
Query: 270 ------ECIP---ATVRSSFANQVRSYVKRALAEGAQIWCGEGVDK-------------- 306
CI +S NQ+ +K + E + GE + +
Sbjct: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE----FYGENIKESPDYERIINLRHFK 289
Query: 307 --LSL---------PARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVI 355
LSL ++A ++ PTV+TD+ ++ M EEIFGP+ +VP + +E I
Sbjct: 290 RILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAI 349
Query: 356 ERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIR-ELN-LPFGGMKSSGIGR 413
N + LA V+S N + R+ + SG V N ++ LN PFGG+ SSG+G
Sbjct: 350 NFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA 409
Query: 414 EGAKDSYDFFTEIKTITVK 432
K S+D F+ + +K
Sbjct: 410 YHGKHSFDTFSHQRPCLLK 428
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 117 bits (294), Expect = 2e-26
Identities = 110/434 (25%), Positives = 185/434 (42%), Gaps = 66/434 (15%)
Query: 45 DEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALART 104
D + ++ REAF + +R + R+ L + L+++ + A ++D K+ +
Sbjct: 2 DPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEV 61
Query: 105 MDIPRS-------VQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLP 157
++ S ++N R + + TQ+D + + P G+ +I+PWN P
Sbjct: 62 SEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSA----FIRKEPFGLVLIIAPWNYP 117
Query: 158 LYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEA 217
L L + A+AAGN V+ KPSE++ +L ++L + V +V G GP+
Sbjct: 118 LNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQ 175
Query: 218 LVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVR 277
L+ H I FTGS + + +A H ++LELGGKNP + D C P TV
Sbjct: 176 LLEH-RFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVD-----DNCDPQTVA 229
Query: 278 SSFANQVRSYVKRALAEGAQIWCGEGVDKLSLPA-------------------------- 311
+ A + + C + + LPA
Sbjct: 230 NRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQK 289
Query: 312 -------------------RNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEE 352
+++ ++ PTV+ D+++ M EEIFGP+ +V S +
Sbjct: 290 QFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLD 349
Query: 353 EVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRE--LNLPFGGMKSSG 410
E IE N + LA +S++ V RV + SG N + +LPFGG+ +SG
Sbjct: 350 EAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
Query: 411 IGREGAKDSYDFFT 424
+GR K S+D F+
Sbjct: 410 MGRYHGKFSFDTFS 423
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 117 bits (294), Expect = 2e-26
Identities = 110/434 (25%), Positives = 185/434 (42%), Gaps = 66/434 (15%)
Query: 45 DEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALART 104
D + ++ REAF + +R + R+ L + L+++ + A ++D K+ +
Sbjct: 2 DPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEV 61
Query: 105 MDIPRS-------VQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLP 157
++ S ++N R + + TQ+D + + P G+ +I+PWN P
Sbjct: 62 SEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSA----FIRKEPFGLVLIIAPWNYP 117
Query: 158 LYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEA 217
L L + A+AAGN V+ KPSE++ +L ++L + V +V G GP+
Sbjct: 118 LNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQ 175
Query: 218 LVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVR 277
L+ H I FTGS + + +A H ++LELGGKNP + D C P TV
Sbjct: 176 LLEH-RFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVD-----DNCDPQTVA 229
Query: 278 SSFANQVRSYVKRALAEGAQIWCGEGVDKLSLPA-------------------------- 311
+ A + + C + + LPA
Sbjct: 230 NRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQK 289
Query: 312 -------------------RNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEE 352
+++ ++ PTV+ D+++ M EEIFGP+ +V S +
Sbjct: 290 QFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLD 349
Query: 353 EVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRE--LNLPFGGMKSSG 410
E IE N + LA +S++ V RV + SG N + +LPFGG+ +SG
Sbjct: 350 EAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
Query: 411 IGREGAKDSYDFFT 424
+GR K S+D F+
Sbjct: 410 MGRYHGKFSFDTFS 423
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 109 bits (273), Expect = 4e-24
Identities = 89/334 (26%), Positives = 149/334 (44%), Gaps = 55/334 (16%)
Query: 142 RAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPP 201
+ P G+ +I+PWN PL L + A+AAG+ V+ KPSE++ T +L ++L + +
Sbjct: 21 KEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-LDQ 79
Query: 202 GVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAI 261
+V G GP+ L+ H ++ I FTGS + + + H ++LELGGKNP
Sbjct: 80 SCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPCY 137
Query: 262 IFEDANLDECIPATVRSSFANQVRSYVKRALAEGAQIWCGEGVDKLSLPA---------- 311
+ D C P TV + A + + C + + LPA
Sbjct: 138 VD-----DNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG 192
Query: 312 -----------------------------------RNQAGYFMLPTVITDIKDESCCMTE 336
N++ ++ PTV+ D+++ M E
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDVQETEPVMQE 252
Query: 337 EIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTN--CW 394
EIFGP+ +V S +E I+ N + LA +S++ V+++ ++ SG N
Sbjct: 253 EIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGGNEGFT 312
Query: 395 LIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKT 428
I L++PFGG+ SG+GR K ++D F+ +T
Sbjct: 313 YISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 109 bits (273), Expect = 4e-24
Identities = 89/334 (26%), Positives = 149/334 (44%), Gaps = 55/334 (16%)
Query: 142 RAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPP 201
+ P G+ +I+PWN PL L + A+AAG+ V+ KPSE++ T +L ++L + +
Sbjct: 21 KEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-LDQ 79
Query: 202 GVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAI 261
+V G GP+ L+ H ++ I FTGS + + + H ++LELGGKNP
Sbjct: 80 SCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPCY 137
Query: 262 IFEDANLDECIPATVRSSFANQVRSYVKRALAEGAQIWCGEGVDKLSLPA---------- 311
+ D C P TV + A + + C + + LPA
Sbjct: 138 VD-----DNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG 192
Query: 312 -----------------------------------RNQAGYFMLPTVITDIKDESCCMTE 336
N++ ++ PTV+ D+++ M E
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDVQETEPVMQE 252
Query: 337 EIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTN--CW 394
EIFGP+ +V S +E I+ N + LA +S++ V+++ ++ SG N
Sbjct: 253 EIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGGNEGFT 312
Query: 395 LIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKT 428
I L++PFGG+ SG+GR K ++D F+ +T
Sbjct: 313 YISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 108 bits (271), Expect = 7e-24
Identities = 95/345 (27%), Positives = 149/345 (43%), Gaps = 59/345 (17%)
Query: 127 ECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVT 186
+ TQ+D + + P G+ +I+PWN PL L + A+AAGN V+ KPSE++
Sbjct: 54 KATQLDSA----FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNV 109
Query: 187 AWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPH 246
+L ++L + V +V G GP+ L+ H I FTGS + + +A H
Sbjct: 110 EKILAEVLPQY-VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAKH 166
Query: 247 CKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYVKRALAEGAQIWCGEGVDK 306
++LELGGKNP + D C P TV + A + + C + +
Sbjct: 167 LTPVTLELGGKNPCYVD-----DNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQE 221
Query: 307 LSLPA---------------------------------------------RNQAGYFMLP 321
LPA +++ ++ P
Sbjct: 222 RLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAP 281
Query: 322 TVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVA 381
TV+ D+++ M EEIFGP+ +V S +E IE N + LA +S++ V RV
Sbjct: 282 TVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVL 341
Query: 382 KKLQSGLVWTNCWLIRE--LNLPFGGMKSSGIGREGAKDSYDFFT 424
+ SG N + +LPFGG+ +SG+GR K S+D F+
Sbjct: 342 TQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 386
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 99.4 bits (246), Expect = 6e-21
Identities = 106/430 (24%), Positives = 178/430 (41%), Gaps = 64/430 (14%)
Query: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102
K + A++AA A W + +R+++ + AD+L A++ QGKT+ A
Sbjct: 99 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 158
Query: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162
+ FRF A ++ + R G ISP+N
Sbjct: 159 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 218
Query: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222
APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S
Sbjct: 219 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 277
Query: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276
+ I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+
Sbjct: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337
Query: 277 RSSF-------ANQVRSYVK---------RALAEGAQIWCGEGVDKL------------- 307
RS+F + R YV R L E ++I G+ +
Sbjct: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 397
Query: 308 -----------SLPA---------RNQAGYFMLPTVITDIKDESCCMTEEIFGPV--TCV 345
S P+ + GYF+ P ++ + M EEIFGPV V
Sbjct: 398 ARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYV 457
Query: 346 VPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWLIREL--N 400
P D +E ++ ++ YGL V+S + V K L+ +G + N +
Sbjct: 458 YPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQ 517
Query: 401 LPFGGMKSSG 410
PFGG ++SG
Sbjct: 518 QPFGGARASG 527
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 99.4 bits (246), Expect = 6e-21
Identities = 106/430 (24%), Positives = 178/430 (41%), Gaps = 64/430 (14%)
Query: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102
K + A++AA A W + +R+++ + AD+L A++ QGKT+ A
Sbjct: 39 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 98
Query: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162
+ FRF A ++ + R G ISP+N
Sbjct: 99 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 158
Query: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222
APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S
Sbjct: 159 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 217
Query: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276
+ I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+
Sbjct: 218 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 277
Query: 277 RSSF-------ANQVRSYVK---------RALAEGAQIWCGEGVDKL------------- 307
RS+F + R YV R L E ++I G+ +
Sbjct: 278 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 337
Query: 308 -----------SLPA---------RNQAGYFMLPTVITDIKDESCCMTEEIFGPV--TCV 345
S P+ + GYF+ P ++ + M EEIFGPV V
Sbjct: 338 ARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYV 397
Query: 346 VPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWLIREL--N 400
P D +E ++ ++ YGL V+S + V K L+ +G + N +
Sbjct: 398 YPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQ 457
Query: 401 LPFGGMKSSG 410
PFGG ++SG
Sbjct: 458 QPFGGARASG 467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,655,277
Number of Sequences: 37866
Number of extensions: 743872
Number of successful extensions: 1889
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1739
Number of HSP's gapped (non-prelim): 75
length of query: 433
length of database: 18,247,518
effective HSP length: 105
effective length of query: 328
effective length of database: 14,271,588
effective search space: 4681080864
effective search space used: 4681080864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.