Guide to the Human Genome
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Search of human proteins with 25777736

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor
[Homo sapiens]
         (563 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...  1142   0.0  
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...  1142   0.0  
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]     1024   0.0  
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]                156   5e-38
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]                 153   5e-37
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]                150   3e-36
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]       148   1e-35
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]       139   5e-33
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho...   137   2e-32
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]       137   3e-32
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]       135   8e-32
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa...   135   1e-31
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap...   127   4e-29
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa...   113   4e-25
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]       107   2e-23
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]        99   8e-21
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ...    98   2e-20
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo...    89   8e-18
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]        84   3e-16
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]                  79   1e-14
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]                 79   1e-14
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]                 79   1e-14
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]       71   2e-12
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]        71   2e-12
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]         71   2e-12
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform...    64   3e-10
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]         64   5e-10
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]        64   5e-10
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]                  63   8e-10
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]                  63   8e-10

>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 1142 bits (2955), Expect = 0.0
 Identities = 563/563 (100%), Positives = 563/563 (100%)

Query: 1   MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR 60
           MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR
Sbjct: 1   MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR 60

Query: 61  MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120
           MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
Sbjct: 61  MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120

Query: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180
           IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
Sbjct: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180

Query: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240
           EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
Sbjct: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240

Query: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300
           ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
Sbjct: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300

Query: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360
           NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
Sbjct: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360

Query: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420
           WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
Sbjct: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420

Query: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480
           CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
Sbjct: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480

Query: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540
           AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
Sbjct: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540

Query: 541 WTSPQVIKETHKPLGDWSYAYMQ 563
           WTSPQVIKETHKPLGDWSYAYMQ
Sbjct: 541 WTSPQVIKETHKPLGDWSYAYMQ 563


>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 1142 bits (2955), Expect = 0.0
 Identities = 563/563 (100%), Positives = 563/563 (100%)

Query: 1   MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR 60
           MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR
Sbjct: 1   MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR 60

Query: 61  MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120
           MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
Sbjct: 61  MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120

Query: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180
           IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
Sbjct: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180

Query: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240
           EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
Sbjct: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240

Query: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300
           ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
Sbjct: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300

Query: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360
           NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
Sbjct: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360

Query: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420
           WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
Sbjct: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420

Query: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480
           CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
Sbjct: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480

Query: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540
           AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
Sbjct: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540

Query: 541 WTSPQVIKETHKPLGDWSYAYMQ 563
           WTSPQVIKETHKPLGDWSYAYMQ
Sbjct: 541 WTSPQVIKETHKPLGDWSYAYMQ 563


>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
          Length = 503

 Score = 1024 bits (2647), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 61  MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120
           MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
Sbjct: 1   MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 60

Query: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180
           IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
Sbjct: 61  IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 120

Query: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240
           EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
Sbjct: 121 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 180

Query: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300
           ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
Sbjct: 181 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 240

Query: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360
           NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
Sbjct: 241 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 300

Query: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420
           WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
Sbjct: 301 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 360

Query: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480
           CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
Sbjct: 361 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 420

Query: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540
           AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
Sbjct: 421 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 480

Query: 541 WTSPQVIKETHKPLGDWSYAYMQ 563
           WTSPQVIKETHKPLGDWSYAYMQ
Sbjct: 481 WTSPQVIKETHKPLGDWSYAYMQ 503


>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
          Length = 512

 Score =  156 bits (394), Expect = 5e-38
 Identities = 137/467 (29%), Positives = 217/467 (46%), Gaps = 32/467 (6%)

Query: 98  DKSLLNKAIEAALAARKE---WDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 154
           DK  ++KA+EAA  A +    W       R ++  + AD++   R A + A   +  GK 
Sbjct: 67  DKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDR-ATLAALETMDTGKP 125

Query: 155 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 212
            + A        I   R+ A +A +++G+   ++P   N   +   E  G   AI+P+NF
Sbjct: 126 FLHAFFIDLEGCIRTLRYFAGWADKIQGK---TIPTDDNVVCFTRHEPIGVCGAITPWNF 182

Query: 213 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271
             +      APAL  GN ++ KP++   L +  +  +++EAG PP ++  VP  GP  G 
Sbjct: 183 PLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGA 242

Query: 272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 331
            ++S   +  I FTGS    K L K+ A          R+  E GGKN   V   AD++ 
Sbjct: 243 AISSHPQINKIAFTGSTEVGK-LVKEAASR----SNLKRVTLELGGKNPCIVCADADLDL 297

Query: 332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391
            V    +  F   GQ C+A SR++V   ++ +   R +E   +  VGDP  D  T     
Sbjct: 298 AVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPF-DVKTEQGPQ 356

Query: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 451
           ID K F +I + +E  +      +  GG   +  G F++P +         I KEEIFGP
Sbjct: 357 IDQKQFDKILELIESGKKE-GAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGP 415

Query: 452 VLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 509
                V P  K+K   +++   ++T YGLT AVF+++ D   +    L   +G  +IN  
Sbjct: 416 -----VQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALE--SGTVWIN-- 466

Query: 510 STGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGD 556
              ++  Q PFGG + SG N +  G + +  +T    +K     LGD
Sbjct: 467 CYNALYAQAPFGGFKMSG-NGRELGEYALAEYTE---VKTVTIKLGD 509


>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
          Length = 501

 Score =  153 bits (386), Expect = 5e-37
 Identities = 129/444 (29%), Positives = 207/444 (46%), Gaps = 28/444 (6%)

Query: 98  DKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 154
           DK  ++KA++AA  A +    W     ++R ++  K AD++   R      ++M G GK 
Sbjct: 56  DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG-GKL 114

Query: 155 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 212
              A ++  A  I   R+ A +A +++G+   ++P   N   Y   E  G    I P+NF
Sbjct: 115 YSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWNF 171

Query: 213 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271
             +       PAL  GN V+ KP++   L +  V  +++EAG PP ++  VP  GP  G 
Sbjct: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231

Query: 272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 331
            ++S   +  + FTGS    K L K+ A          R+  E GGK+   V   AD+++
Sbjct: 232 AISSHMDIDKVAFTGSTEVGK-LIKEAAGK----SNLKRVTLELGGKSPCIVLADADLDN 286

Query: 332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391
            V       F + GQ C A SR++V  S++ +   R +E   +  +G+P    G      
Sbjct: 287 AVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGPQ 345

Query: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 451
           ID + + +I   +E  +   +     GG   +  GYFV+P +  +   +  I KEEIFGP
Sbjct: 346 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGP 404

Query: 452 VLSVYVYP--DDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 509
           V  +  +   DD  K       + T YGL+  VF++D D     +  L+  AG  ++N  
Sbjct: 405 VQQIMKFKSLDDVIKRA-----NNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN-- 455

Query: 510 STGSIVGQQPFGGARASGTNDKPG 533
             G +  Q PFGG + SG   + G
Sbjct: 456 CYGVVSAQCPFGGFKMSGNGRELG 479


>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
          Length = 518

 Score =  150 bits (379), Expect = 3e-36
 Identities = 125/458 (27%), Positives = 220/458 (48%), Gaps = 36/458 (7%)

Query: 88  GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 147
           G  +A F  + +  +N A++ A AA K W  K   +R +I L+AA ++   R  EI    
Sbjct: 61  GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR-EREDEIATME 119

Query: 148 MVGQGKTVIQA--EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVA 205
            +  GK++ +A  +ID + + ++++   A  A  + G+  I +P  +     R   G   
Sbjct: 120 CINNGKSIFEARLDIDISWQCLEYY---AGLAASMAGEH-IQLPGGSFGYTRREPLGVCV 175

Query: 206 AISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA 264
            I  +N+     +   APAL  GN +++KPS    +++  +  I  EAG+PP +   V  
Sbjct: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235

Query: 265 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 324
            G   G  +     +  ++FTGSVPT   + +  A+ +        +  E GGK+   + 
Sbjct: 236 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP------VTLELGGKSPLIIF 288

Query: 325 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDF 384
              D+ + V G L + F   GQ C   +R++V   +  +    ++++  RIK+GDP  + 
Sbjct: 289 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLE- 347

Query: 385 GTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG--------KCDDSVGYFVEPCIVES 436
            T    +I+     R+  +++ A+      +L GG        K  D  GY++ PC++ +
Sbjct: 348 DTRMGPLINRPHLERVLGFVKVAKEQ-GAKVLCGGDIYVPEDPKLKD--GYYMRPCVLTN 404

Query: 437 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 496
                  +KEEIFGPV+S+  +  D   E L+  + TT +GL   VF++D   +Q A +V
Sbjct: 405 CRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGLAAGVFTRD---IQRAHRV 458

Query: 497 LRN-AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
           +    AG  +IN+ +   +  + PFGG + SG   + G
Sbjct: 459 VAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG 494


>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
          Length = 518

 Score =  148 bits (374), Expect = 1e-35
 Identities = 125/454 (27%), Positives = 217/454 (47%), Gaps = 28/454 (6%)

Query: 88  GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
           G +V +   ADK+ ++KA++AA  A      W     ++R ++  K AD++   R     
Sbjct: 63  GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122

Query: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
            +++ G GK  +QA       +I  FR+ A +A ++ G   +++P   +   +   E  G
Sbjct: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178

Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
               I P+NF  +      APAL  GN V+ KP++   L++  +  +++EAG PP +I  
Sbjct: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINI 238

Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
           +P  GP  G  + S   +  I FTGS    K + +   ++        R+  E GGK+ +
Sbjct: 239 LPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS-----NLKRVTLELGGKSPN 293

Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
            +   AD++  V    +  F   GQ C+A SR++V  S++ +   R +E   R  VG P 
Sbjct: 294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 353

Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
            D  T     ID K + +I + ++ +  +    +  GGK     G+F+EP +  +     
Sbjct: 354 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 411

Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
            I KEEIFGPV  +      ++K   ++++  + + +GL  AVF+ D +     +  ++ 
Sbjct: 412 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 465

Query: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
            AG  +IN     ++  Q PFGG + SG   + G
Sbjct: 466 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 496


>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
          Length = 517

 Score =  139 bits (351), Expect = 5e-33
 Identities = 119/454 (26%), Positives = 213/454 (46%), Gaps = 28/454 (6%)

Query: 88  GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
           G  +      D++ +++A++AA  A +    W     ++R ++  + AD++   R   + 
Sbjct: 62  GEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDR-VYLA 120

Query: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
           +   +  GK   ++      E+I  +R+ A +A +  G+   ++P       +   E  G
Sbjct: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK---TIPMDGQHFCFTRHEPVG 177

Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
               I P+NF  +      APAL  GN V+ K ++   L++  +  +++EAG PP ++  
Sbjct: 178 VCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNI 237

Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
           +   GP  G  +     +  + FTGS     HL ++ A + +      R+  E GGK+  
Sbjct: 238 ITGYGPTAGAAIAQHVDVDKVAFTGSTEV-GHLIQKAAGDSN----LKRVTLELGGKSPS 292

Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
            V   AD+E  V     + F   GQ C A SR +V  S++ +   R +E+  + KVG+P 
Sbjct: 293 IVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPF 352

Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
           E   T     +D + F R+  +++  +      +L GG+     G+F++P +        
Sbjct: 353 E-LDTQQGPQVDKEQFERVLGYIQLGQKE-GAKLLCGGERFGERGFFIKPTVFGGVQDDM 410

Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
            I KEEIFGPV  ++     K+K+  ++V+  + T YGL  AVF++D D     T+ L+ 
Sbjct: 411 RIAKEEIFGPVQPLF-----KFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQ- 464

Query: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
            AG  ++N  +   +    PFGG + SG   + G
Sbjct: 465 -AGTVWVN--TYNIVTCHTPFGGFKESGNGRELG 495


>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
           sapiens]
          Length = 517

 Score =  137 bits (346), Expect = 2e-32
 Identities = 122/454 (26%), Positives = 206/454 (45%), Gaps = 28/454 (6%)

Query: 88  GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
           G  + +    DK  ++KA++AA AA +    W     + R ++  + AD++   R   + 
Sbjct: 62  GEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDR-TYLA 120

Query: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
           A   +  GK  + + +     ++   R+ A +A +  G+   ++P   +   Y   E  G
Sbjct: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK---TIPIDGDFFSYTRHEPVG 177

Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
               I P+NF  +       PAL  GNVV+ K ++   L +  V  +++EAG PP ++  
Sbjct: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237

Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
           VP  GP  G  + S E +  + FTGS    + +  QVA          R+  E GGK+ +
Sbjct: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVI--QVAAGSS---NLKRVTLELGGKSPN 292

Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
            +   AD++  V     + F   GQ C A SR +V   ++ +   R +       VG+P 
Sbjct: 293 IIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPF 352

Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
            D  T     +D   F +I  ++   +   +  +  GG   D  GYF++P +        
Sbjct: 353 -DSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR-GYFIQPTVFGDVQDGM 410

Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
            I KEEIFGPV+ +      K+K   ++V   + ++YGL  AVF++D D     ++ L+ 
Sbjct: 411 TIAKEEIFGPVMQIL-----KFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQ- 464

Query: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
            AG  ++N         Q PFGG + SG+  + G
Sbjct: 465 -AGTVWVNCYDV--FGAQSPFGGYKMSGSGRELG 495


>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
          Length = 422

 Score =  137 bits (344), Expect = 3e-32
 Identities = 114/417 (27%), Positives = 199/417 (47%), Gaps = 25/417 (5%)

Query: 122 ADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELE 181
           ++R ++  K AD++   R      +++ G GK  +QA       +I  FR+ A +A ++ 
Sbjct: 4   SERGRLLDKLADLVERDRAVLATMESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIH 62

Query: 182 GQQPISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTA 238
           G   +++P   +   +   E  G    I P+NF  +      APAL  GN V+ KP++  
Sbjct: 63  G---MTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQT 119

Query: 239 MLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298
            L++  +  +++EAG PP +I  +P  GP  G  + S   +  I FTGS    K + +  
Sbjct: 120 PLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAA 179

Query: 299 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 358
            ++        R+  E GGK+ + +   AD++  V    +  F   GQ C+A SR++V  
Sbjct: 180 GRS-----NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 234

Query: 359 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418
           S++ +   R +E   R  VG P  D  T     ID K + +I + ++ +  +    +  G
Sbjct: 235 SIYEEFVRRSVERAKRRVVGSPF-DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECG 292

Query: 419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSY 476
           GK     G+F+EP +  +      I KEEIFGPV  +      ++K   ++++  + + +
Sbjct: 293 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDF 347

Query: 477 GLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
           GL  AVF+ D +     +  ++  AG  +IN     ++  Q PFGG + SG   + G
Sbjct: 348 GLVAAVFTNDINKALTVSSAMQ--AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 400


>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
          Length = 487

 Score =  135 bits (341), Expect = 8e-32
 Identities = 114/437 (26%), Positives = 198/437 (45%), Gaps = 24/437 (5%)

Query: 99  KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 158
           K  +  A++AA  A   W  +   +R+++  + AD+L         A++   QGKT+  A
Sbjct: 44  KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102

Query: 159 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 218
                   +  FRF A  ++    +              R   G    ISP+N       
Sbjct: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162

Query: 219 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 277
              APA+  GN V+ KPS+   + ++ + ++L +AG+PP ++  V   GP  G+ + S  
Sbjct: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222

Query: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337
            +  I+FTGS PT + + +  A +        +L+ E GGKN   +   A+++  +  T+
Sbjct: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276

Query: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 397
           RS+F   G+ C   SR++V  S++ +   R +E   + KVG P++       A+I     
Sbjct: 277 RSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL-VSIGALISKAHL 335

Query: 398 ARIKKWLEHARSSPSLTILAGGKCD-------DSVGYFVEPCIVESKDPQEPIMKEEIFG 450
            +++ +++ A +     I  G   D       +  GYF+ P ++     +   M EEIFG
Sbjct: 336 EKVRSYVKRALAE-GAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394

Query: 451 PVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510
           PV    V P D  +E ++  ++   YGL   V+S +   V    K L+  +G  + N   
Sbjct: 395 PV--TCVVPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWL 449

Query: 511 TGSIVGQQPFGGARASG 527
              +    PFGG ++SG
Sbjct: 450 IREL--NLPFGGMKSSG 464


>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
           sapiens]
          Length = 923

 Score =  135 bits (339), Expect = 1e-31
 Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 29/451 (6%)

Query: 88  GHKVAKFCYADKSLLNKAIEAALAARK--EWDLKPIADRAQIFLKAADMLSGPRRAEILA 145
           G  + K  YA  + ++KA+ AA  A +  EW      +R ++  + AD+L    + E+  
Sbjct: 468 GSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLE-ENQEELAT 526

Query: 146 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PISVPPSTNSTVYRGLE--G 202
              +  G     A        +  FR+ A +  +++G   PI+      +  +   E  G
Sbjct: 527 IEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLG 586

Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
             A I P+N+  +      A  L  GN ++ KP+    L +     +  +AG P  +I  
Sbjct: 587 VCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINI 646

Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
           +P  G + G  ++    +  + FTGS P  K + K  A +        +++ E GGK+  
Sbjct: 647 IPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVS-----NLKKVSLELGGKSPL 701

Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
            +    +++  V   + + F   G+ C A  RL+V  S+  +   R++EE  ++K+GDP 
Sbjct: 702 IIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPL 761

Query: 382 E---DFGTFFSAVIDAKSFARIKKWLEHARS--SPSLTILAGGKCDDSVGYFVEPCIVES 436
           +   D G            A ++K L++  +      T++ GG+     G+F+EP +   
Sbjct: 762 DRSTDHG-------PQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTD 814

Query: 437 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 496
            +    + KEE FGP++ +  + +      LQ  +S T YGL   VF++D +     ++ 
Sbjct: 815 VEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANS-TEYGLASGVFTRDINKAMYVSEK 873

Query: 497 LRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
           L   AG  +IN  +   +    PFGG + SG
Sbjct: 874 LE--AGTVFINTYNKTDVAA--PFGGVKQSG 900


>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
           sapiens]
          Length = 902

 Score =  127 bits (318), Expect = 4e-29
 Identities = 112/446 (25%), Positives = 194/446 (43%), Gaps = 19/446 (4%)

Query: 88  GHKVAKFCYADKSLLNKAIEAALAARKE--WDLKPIADRAQIFLKAADMLSGPRRAEILA 145
           G  + +   A  + ++KA+ AA  A +   W      DR ++  + AD++    + E+  
Sbjct: 447 GSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLME-QHQEELAT 505

Query: 146 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PIS-VPPSTNSTVYRGLE-G 202
              +  G     A        I  FR+ A +  +++G   PI+   P+ N T+ R    G
Sbjct: 506 IEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVG 565

Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
               I P+N+  +  +   A  L  GN V+ KP+    L +     +  +AG+P  ++  
Sbjct: 566 VCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNV 625

Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
           +P  G L G  ++    +  I FTGS    KH+ K  A          +++ E GGK+  
Sbjct: 626 LPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA-----ISNVKKVSLELGGKSPL 680

Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
            +    D+   V   + S F   G+ C A  RL+V  S+  +   R++EE  ++KVG+P 
Sbjct: 681 IIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPL 740

Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
            D  T            ++ ++ +H       T++ GG      G+F EP +    +   
Sbjct: 741 -DRDTDHGPQNHHAHLVKLMEYCQHG-VKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHM 798

Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAA 501
            I KEE FGPV+ +  + D      L   ++ T +GL   VF++D +     +  L+  A
Sbjct: 799 FIAKEESFGPVMIISRFADGDLDAVLSRANA-TEFGLASGVFTRDINKALYVSDKLQ--A 855

Query: 502 GNFYINDKSTGSIVGQQPFGGARASG 527
           G  ++N  +   +    PFGG + SG
Sbjct: 856 GTVFVNTYNKTDVAA--PFGGFKQSG 879


>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
           sapiens]
          Length = 539

 Score =  113 bits (283), Expect = 4e-25
 Identities = 119/476 (25%), Positives = 205/476 (43%), Gaps = 45/476 (9%)

Query: 80  YQVSPFNHGHKVAKFCYADKSLLNKAIEAALA--------ARKEWDLK---PIADRAQIF 128
           Y  S    G  +  +C A+   + +  +A++A        AR+ W +    P   R +I 
Sbjct: 55  YNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIV 114

Query: 129 LKAADMLSGPRRAEILAKTM-VGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPIS 187
            +  D L    + ++L   + +  GK +++  +    E +D       YAV L       
Sbjct: 115 RQIGDALR--EKIQVLGSLVSLEMGKILVEG-VGEVQEYVDI----CDYAVGLSRMIGGP 167

Query: 188 VPPSTNSTVYRGLE-----GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLA 241
           + PS  S  +  +E     G V  I+ FNF  A+ G       + GNV LWK + T  L 
Sbjct: 168 ILPSERSG-HALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLI 226

Query: 242 SYAVYRILR---EAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298
           S AV +I+    E    P  I  +   G   G  +   E +  ++FTGS    K +   V
Sbjct: 227 SVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV 286

Query: 299 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 358
            +       F R   E GG N       AD+  VV   L +A    GQ+C+   RL++  
Sbjct: 287 QER------FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHE 340

Query: 359 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418
           S+  ++  RL + +++I+VG+P  D    +  +   ++ +     +E A+     T++ G
Sbjct: 341 SIHDEVVNRLKKAYAQIRVGNP-WDPNVLYGPLHTKQAVSMFLGAVEEAKKEGG-TVVYG 398

Query: 419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGL 478
           GK  D  G +VEP IV        I   E F P+L V+ +   K +E +   ++    GL
Sbjct: 399 GKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKF---KNEEEVFAWNNEVKQGL 455

Query: 479 TGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIV-----GQQPFGGARASGTN 529
           + ++F++D   +        +  G   +N  ++G+ +     G++  GG R SG++
Sbjct: 456 SSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSD 511


>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
          Length = 480

 Score =  107 bits (268), Expect = 2e-23
 Identities = 111/454 (24%), Positives = 197/454 (43%), Gaps = 66/454 (14%)

Query: 88  GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
           G +V +   ADK+ ++KA++AA  A      W     ++R ++  K AD++   R     
Sbjct: 63  GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122

Query: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
            +++ G GK  +QA       +I  FR+ A +A ++ G   +++P   +   +   E  G
Sbjct: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178

Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
               I P+NF  +      APAL  GN V+ KP++   L++  +  +++E G        
Sbjct: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG-------- 230

Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
                                              ++ Q         R+  E GGK+ +
Sbjct: 231 -----------------------------------KLIQEAAGRSNLKRVTLELGGKSPN 255

Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
            +   AD++  V    +  F   GQ C+A SR++V  S++ +   R +E   R  VG P 
Sbjct: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315

Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
            D  T     ID K + +I + ++ +  +    +  GGK     G+F+EP +  +     
Sbjct: 316 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 373

Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
            I KEEIFGPV  +      ++K   ++++  + + +GL  AVF+ D +     +  ++ 
Sbjct: 374 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 427

Query: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
            AG  +IN     ++  Q PFGG + SG   + G
Sbjct: 428 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 458


>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
          Length = 433

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 106/430 (24%), Positives = 178/430 (41%), Gaps = 64/430 (14%)

Query: 99  KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 158
           K  +  A++AA  A   W  +   +R+++  + AD+L         A++   QGKT+  A
Sbjct: 44  KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102

Query: 159 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 218
                   +  FRF A  ++    +              R   G    ISP+N       
Sbjct: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162

Query: 219 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 277
              APA+  GN V+ KPS+   + ++ + ++L +AG+PP ++  V   GP  G+ + S  
Sbjct: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222

Query: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337
            +  I+FTGS PT + + +  A +        +L+ E GGKN   +   A+++  +  T+
Sbjct: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276

Query: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 397
           RS+F       +   R YV          R L E ++I  G+  +               
Sbjct: 277 RSSF-------ANQVRSYVK---------RALAEGAQIWCGEGVDKL------------- 307

Query: 398 ARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYV 457
                      S P+          +  GYF+ P ++     +   M EEIFGPV    V
Sbjct: 308 -----------SLPA---------RNQAGYFMLPTVITDIKDESCCMTEEIFGPV--TCV 345

Query: 458 YPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQ 517
            P D  +E ++  ++   YGL   V+S +   V    K L+  +G  + N      +   
Sbjct: 346 VPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWLIREL--N 400

Query: 518 QPFGGARASG 527
            PFGG ++SG
Sbjct: 401 LPFGGMKSSG 410


>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
           sapiens]
          Length = 535

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 105/431 (24%), Positives = 192/431 (44%), Gaps = 28/431 (6%)

Query: 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 161
           A+ AA  A   W      +R+ +  K  +++   +  + LA+ +  + GK + +A  EI 
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158

Query: 162 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 220
            +A  +++F   A+    + G    +      + V +   G  A I+P+NF +A+     
Sbjct: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215

Query: 221 GAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA---DGPLFGDTVTSSE 277
           GA    G  V+ KP++    ++ A+  +  +AG+P  +   +P    +    G+ + +  
Sbjct: 216 GAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDP 275

Query: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337
            +  I+FTGS  T K L    A ++ R      ++ E GG     V  SA+V+  V+G +
Sbjct: 276 LVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVFDSANVDQAVAGAM 329

Query: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAEDFGTFFSAVIDAKS 396
            S F   GQ C   ++  V   +         E   + ++VG+  E+ GT    +I+ K+
Sbjct: 330 ASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE-GTTQGPLINEKA 388

Query: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456
             +++K +  A  S   T++ GGK       F EP ++ +         EE FGP+  V 
Sbjct: 389 VEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVI 447

Query: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516
            +  D  +E + + ++    GL G  +SQD   +    + L    G   +N+    S+  
Sbjct: 448 KF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGMVGVNEGLISSV-- 500

Query: 517 QQPFGGARASG 527
           + PFGG + SG
Sbjct: 501 ECPFGGVKQSG 511


>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
           sapiens]
          Length = 548

 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 105/444 (23%), Positives = 193/444 (43%), Gaps = 41/444 (9%)

Query: 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 161
           A+ AA  A   W      +R+ +  K  +++   +  + LA+ +  + GK + +A  EI 
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158

Query: 162 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 220
            +A  +++F   A+    + G    +      + V +   G  A I+P+NF +A+     
Sbjct: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215

Query: 221 GAPALMGNVVLWKPSDTAMLASYAVYRILR-------------EAGLPPNIIQFVPA--- 264
           GA    G  V+ KP++    ++ A+  + +             +AG+P  +   +P    
Sbjct: 216 GAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRK 275

Query: 265 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 324
           +    G+ + +   +  I+FTGS  T K L    A ++ R      ++ E GG     V 
Sbjct: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVF 329

Query: 325 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAED 383
            SA+V+  V+G + S F   GQ C   ++  V   +         E   + ++VG+  E+
Sbjct: 330 DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 389

Query: 384 FGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPI 443
            GT    +I+ K+  +++K +  A  S   T++ GGK       F EP ++ +       
Sbjct: 390 -GTTQGPLINEKAVEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLC 447

Query: 444 MKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGN 503
             EE FGP+  V  +  D  +E + + ++    GL G  +SQD   +    + L    G 
Sbjct: 448 THEETFGPLAPVIKF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGM 502

Query: 504 FYINDKSTGSIVGQQPFGGARASG 527
             +N+    S+  + PFGG + SG
Sbjct: 503 VGVNEGLISSV--ECPFGGVKQSG 524


>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
          Length = 535

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 97/396 (24%), Positives = 169/396 (42%), Gaps = 26/396 (6%)

Query: 97  ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVI 156
           A K+ ++ AI +   A   W    +  R Q+ L+   ++    + EI     + QGKT+ 
Sbjct: 74  ATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLK-EIAKLITLEQGKTLA 132

Query: 157 QAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIG 216
            AE D    L             + G+   S+    +   YR   G  A I+PFNF A+ 
Sbjct: 133 DAEGDVFRGL-QVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191

Query: 217 GNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTS 275
                  A++ GN  L KPS+    A+  + ++L+++G P   +  +        + +  
Sbjct: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAV-NFICD 250

Query: 276 SEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSG 335
              +  I+F GS    ++++++ +++        R+    G KN   V   A+ E+ ++ 
Sbjct: 251 HPDIKAISFVGSNKAGEYIFERGSRH------GKRVQANMGAKNHGVVMPDANKENTLNQ 304

Query: 336 TLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS---RIKVGD-PAEDFGTFFSAV 391
            + +AF   GQ+C A S   +       +    L EH+   R+  GD P  D G     +
Sbjct: 305 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPE--LVEHAKNLRVNAGDQPGADLGP----L 358

Query: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSV---GYFVEPCIVESKDPQEPIMKEEI 448
           I  ++  R+   ++      +  +L G K        G FV P I+ +  P     KEEI
Sbjct: 359 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI 418

Query: 449 FGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFS 484
           FGPVL   V   +   E +Q+V++   YG   A+F+
Sbjct: 419 FGPVL--VVLETETLDEAIQIVNN-NPYGNGTAIFT 451


>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)

Query: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159
           S +++A++ A AA      +P+  R Q  L+A   L   +  E++        K    A 
Sbjct: 2   SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212
            +    +++   +  +   E    +P+   P T      ++    G V  I     PFN 
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269
           T     + GA A  GN V+ KPS+ +   +  +  I+ +     L P I   VP    L 
Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177

Query: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329
                  E    I +TGS    K +    A++L        +  E GGK+  +V ++ D+
Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225

Query: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387
           +          F   GQ C A   +    S+  QI  +L +        D   + D+G  
Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284

Query: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447
              +I A+ F R+   +E  +       +A G   D+   ++ P I+   DPQ P+M+EE
Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334

Query: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507
           IFGPVL +        +E +Q ++      L   +FS +  V+++   +   ++G    N
Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389

Query: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533
           D      +   PFGG   SG     G
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415


>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)

Query: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159
           S +++A++ A AA      +P+  R Q  L+A   L   +  E++        K    A 
Sbjct: 2   SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212
            +    +++   +  +   E    +P+   P T      ++    G V  I     PFN 
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269
           T     + GA A  GN V+ KPS+ +   +  +  I+ +     L P I   VP    L 
Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177

Query: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329
                  E    I +TGS    K +    A++L        +  E GGK+  +V ++ D+
Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225

Query: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387
           +          F   GQ C A   +    S+  QI  +L +        D   + D+G  
Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284

Query: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447
              +I A+ F R+   +E  +       +A G   D+   ++ P I+   DPQ P+M+EE
Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334

Query: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507
           IFGPVL +        +E +Q ++      L   +FS +  V+++   +   ++G    N
Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389

Query: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533
           D      +   PFGG   SG     G
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415


>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)

Query: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159
           S +++A++ A AA      +P+  R Q  L+A   L   +  E++        K    A 
Sbjct: 2   SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212
            +    +++   +  +   E    +P+   P T      ++    G V  I     PFN 
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269
           T     + GA A  GN V+ KPS+ +   +  +  I+ +     L P I   VP    L 
Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177

Query: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329
                  E    I +TGS    K +    A++L        +  E GGK+  +V ++ D+
Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225

Query: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387
           +          F   GQ C A   +    S+  QI  +L +        D   + D+G  
Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284

Query: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447
              +I A+ F R+   +E  +       +A G   D+   ++ P I+   DPQ P+M+EE
Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334

Query: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507
           IFGPVL +        +E +Q ++      L   +FS +  V+++   +   ++G    N
Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389

Query: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533
           D      +   PFGG   SG     G
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415


>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)

Query: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
           G V  I+P+N+     NL   P +     GN V+ KPS+     S  V +IL E  LP  
Sbjct: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157

Query: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
           + Q    V   GP   +T    EH    I FTGS    K +    A++L        +  
Sbjct: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209

Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
           E GGKN  +V  + D ++V +      +   GQ C A   +     +  ++   L    +
Sbjct: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269

Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
           R    DP          +I+ K F R++  L   R      +  GG+ D+S  Y + P +
Sbjct: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320

Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493
           +      EP+M+EEIFGP+L +         E ++ ++      L    FS    VV+  
Sbjct: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377

Query: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
             + + ++G F  ND      +   PFGG  ASG
Sbjct: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409


>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
          Length = 431

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)

Query: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
           G V  I+P+N+     NL   P +     GN V+ KPS+     S  V +IL E  LP  
Sbjct: 69  GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 120

Query: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
           + Q    V   GP   +T    EH    I FTGS    K +    A++L        +  
Sbjct: 121 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 172

Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
           E GGKN  +V  + D ++V +      +   GQ C A   +     +  ++   L    +
Sbjct: 173 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 232

Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
           R    DP          +I+ K F R++  L   R      +  GG+ D+S  Y + P +
Sbjct: 233 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 283

Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493
           +      EP+M+EEIFGP+L +         E ++ ++      L    FS    VV+  
Sbjct: 284 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 340

Query: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
             + + ++G F  ND      +   PFGG  ASG
Sbjct: 341 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 372


>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)

Query: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
           G V  I+P+N+     NL   P +     GN V+ KPS+     S  V +IL E  LP  
Sbjct: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157

Query: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
           + Q    V   GP   +T    EH    I FTGS    K +    A++L        +  
Sbjct: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209

Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
           E GGKN  +V  + D ++V +      +   GQ C A   +     +  ++   L    +
Sbjct: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269

Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
           R    DP          +I+ K F R++  L   R      +  GG+ D+S  Y + P +
Sbjct: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320

Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493
           +      EP+M+EEIFGP+L +         E ++ ++      L    FS    VV+  
Sbjct: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377

Query: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
             + + ++G F  ND      +   PFGG  ASG
Sbjct: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409


>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
           [Homo sapiens]
          Length = 802

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 115/472 (24%), Positives = 188/472 (39%), Gaps = 64/472 (13%)

Query: 88  GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 147
           G  +A    A    +  A+EAA  A K W   P   RAQ   + A+++   +R     ++
Sbjct: 65  GENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLES 124

Query: 148 MV-GQG-KTVIQAEIDAAAELIDFFRFNAKYAVE-LEGQQPISVPPSTNSTVYRGLEGFV 204
           +V G+  + V   ++  A +L+ +    A    E L G +P+               G +
Sbjct: 125 LVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM---------------GVI 169

Query: 205 AAISP--FNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFV 262
             I P  F+F  +   +  A A+   VV   P   A  A   + ++  E G  P I+  +
Sbjct: 170 GLILPPTFSFLEMMWRICPALAVGCTVVALVP--PASPAPLLLAQLAGELGPFPGILNVL 227

Query: 263 PADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGEC------- 315
                L    + S   +  + F G+    + L +              LAGEC       
Sbjct: 228 SGPASLV-PILASQPGIRKVAFCGAPEEGRALRRS-------------LAGECAELGLAL 273

Query: 316 GGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRI 375
           G ++   +  +ADV+S V G + +A+   G       RL +  S+W +   RL E   R+
Sbjct: 274 GTESLLLLTDTADVDSAVEGVVDAAWSDRG---PGGLRLLIQESVWDEAMRRLQERMGRL 330

Query: 376 KVG---DPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPC 432
           + G   D A D G   +A  D      +++++  A+S  +    AG     S   F  P 
Sbjct: 331 RSGRGLDGAVDMGARGAAACDL-----VQRFVREAQSQGAQVFQAGDV--PSERPFYPPT 383

Query: 433 IVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQE 492
           +V +  P  P  + E+  PV  V   P    KE L LV + T  G + +V+S+      E
Sbjct: 384 LVSNLPPASPCAQVEVPWPV--VVASPFRTAKEAL-LVANGTPRGGSASVWSERLGQALE 440

Query: 493 ATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSP 544
               L+   G  +IN  + G      P GG + SG +   GGP  +  +  P
Sbjct: 441 LGYGLQ--VGTVWIN--AHGLRDPSVPTGGCKESGCS-WHGGPDGLYEYLRP 487


>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
          Length = 485

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)

Query: 219 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 276
           L GA A  GN V+ KPS+ +   +  + ++L     P  + Q  ++  +G +   T    
Sbjct: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175

Query: 277 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 336
           +    I +TG+    K + +  A++L        +  E GGK+  ++ +  D++ V    
Sbjct: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229

Query: 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 396
               +   GQ C A   +    SL  QI  ++ E       G+  ++    +  +I+ + 
Sbjct: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287

Query: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456
           F RI   LE  +      I  GG+ D++  Y + P ++   DP+  +M+EEIFGP+L   
Sbjct: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338

Query: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516
           + P     E +  ++      L   VFS +  +++    +   ++G    ND      + 
Sbjct: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395

Query: 517 QQPFGGARASG 527
             PFGG  +SG
Sbjct: 396 SFPFGGVGSSG 406


>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
          Length = 508

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)

Query: 219 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 276
           L GA A  GN V+ KPS+ +   +  + ++L     P  + Q  ++  +G +   T    
Sbjct: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175

Query: 277 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 336
           +    I +TG+    K + +  A++L        +  E GGK+  ++ +  D++ V    
Sbjct: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229

Query: 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 396
               +   GQ C A   +    SL  QI  ++ E       G+  ++    +  +I+ + 
Sbjct: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287

Query: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456
           F RI   LE  +      I  GG+ D++  Y + P ++   DP+  +M+EEIFGP+L   
Sbjct: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338

Query: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516
           + P     E +  ++      L   VFS +  +++    +   ++G    ND      + 
Sbjct: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395

Query: 517 QQPFGGARASG 527
             PFGG  +SG
Sbjct: 396 SFPFGGVGSSG 406


>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 100/381 (26%), Positives = 156/381 (40%), Gaps = 60/381 (15%)

Query: 202 GFVAAISPFNF----TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
           G V  I+P+N+    T +   L GA A  G+ V+ KPS+     S    ++L E  LP  
Sbjct: 25  GLVLIIAPWNYPLNLTLV--LLVGALAA-GSCVVLKPSEI----SQGTEKVLAEV-LPQY 76

Query: 258 IIQF---VPADGPLFGDTVTSSEH-LCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
           + Q    V   GP   +T    EH L  I FTGS    K +     ++L        +  
Sbjct: 77  LDQSCFAVVLGGPQ--ETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTP------VTL 128

Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
           E GGKN  +V  + D ++V +      +   GQ C A   +     +  ++   L    +
Sbjct: 129 ELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 188

Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
           R    DP          +I+ K F R++  L   R      +  GG+ ++S  Y + P +
Sbjct: 189 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSNESDRY-IAPTV 239

Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSY------GLTGAVFSQDK 487
           +      EP+M+EEIFGP+L +           +Q VD    +       L    FS   
Sbjct: 240 LVDVQETEPVMQEEIFGPILPIV---------NVQSVDEAIKFINRQEKPLALYAFSNSS 290

Query: 488 DVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGG------PHY---I 538
            VV +  +  R ++G+F  N+  T   +   PFGG   SG     G        H+   +
Sbjct: 291 QVVNQMLE--RTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCL 348

Query: 539 LRWTSPQVIKETH-KPLGDWS 558
           L  +  + +KE H  P  DW+
Sbjct: 349 LAPSGLEKLKEIHYPPYTDWN 369


>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 100/381 (26%), Positives = 156/381 (40%), Gaps = 60/381 (15%)

Query: 202 GFVAAISPFNF----TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
           G V  I+P+N+    T +   L GA A  G+ V+ KPS+     S    ++L E  LP  
Sbjct: 25  GLVLIIAPWNYPLNLTLV--LLVGALAA-GSCVVLKPSEI----SQGTEKVLAEV-LPQY 76

Query: 258 IIQF---VPADGPLFGDTVTSSEH-LCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
           + Q    V   GP   +T    EH L  I FTGS    K +     ++L        +  
Sbjct: 77  LDQSCFAVVLGGPQ--ETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTP------VTL 128

Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
           E GGKN  +V  + D ++V +      +   GQ C A   +     +  ++   L    +
Sbjct: 129 ELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 188

Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
           R    DP          +I+ K F R++  L   R      +  GG+ ++S  Y + P +
Sbjct: 189 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSNESDRY-IAPTV 239

Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSY------GLTGAVFSQDK 487
           +      EP+M+EEIFGP+L +           +Q VD    +       L    FS   
Sbjct: 240 LVDVQETEPVMQEEIFGPILPIV---------NVQSVDEAIKFINRQEKPLALYAFSNSS 290

Query: 488 DVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGG------PHY---I 538
            VV +  +  R ++G+F  N+  T   +   PFGG   SG     G        H+   +
Sbjct: 291 QVVNQMLE--RTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCL 348

Query: 539 LRWTSPQVIKETH-KPLGDWS 558
           L  +  + +KE H  P  DW+
Sbjct: 349 LAPSGLEKLKEIHYPPYTDWN 369


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,416,913
Number of Sequences: 37866
Number of extensions: 1037155
Number of successful extensions: 2175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2067
Number of HSP's gapped (non-prelim): 40
length of query: 563
length of database: 18,247,518
effective HSP length: 107
effective length of query: 456
effective length of database: 14,195,856
effective search space: 6473310336
effective search space used: 6473310336
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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