BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo sapiens] (563 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 1142 0.0 gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 1142 0.0 gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 1024 0.0 gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 156 5e-38 gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 153 5e-37 gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 150 3e-36 gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 148 1e-35 gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 139 5e-33 gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 137 2e-32 gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 137 3e-32 gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 135 8e-32 gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 135 1e-31 gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 127 4e-29 gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 113 4e-25 gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 107 2e-23 gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 99 8e-21 gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 98 2e-20 gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 89 8e-18 gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 84 3e-16 gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 79 1e-14 gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 79 1e-14 gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 79 1e-14 gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 71 2e-12 gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 71 2e-12 gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 71 2e-12 gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 64 3e-10 gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 64 5e-10 gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 64 5e-10 gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 63 8e-10 gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 63 8e-10 >gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo sapiens] Length = 563 Score = 1142 bits (2955), Expect = 0.0 Identities = 563/563 (100%), Positives = 563/563 (100%) Query: 1 MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR 60 MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR Sbjct: 1 MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR 60 Query: 61 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP Sbjct: 61 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120 Query: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL Sbjct: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180 Query: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML Sbjct: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240 Query: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ Sbjct: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300 Query: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL Sbjct: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360 Query: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK Sbjct: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420 Query: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG Sbjct: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480 Query: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR Sbjct: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540 Query: 541 WTSPQVIKETHKPLGDWSYAYMQ 563 WTSPQVIKETHKPLGDWSYAYMQ Sbjct: 541 WTSPQVIKETHKPLGDWSYAYMQ 563 >gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo sapiens] Length = 563 Score = 1142 bits (2955), Expect = 0.0 Identities = 563/563 (100%), Positives = 563/563 (100%) Query: 1 MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR 60 MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR Sbjct: 1 MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR 60 Query: 61 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP Sbjct: 61 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120 Query: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL Sbjct: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180 Query: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML Sbjct: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240 Query: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ Sbjct: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300 Query: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL Sbjct: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360 Query: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK Sbjct: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420 Query: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG Sbjct: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480 Query: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR Sbjct: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540 Query: 541 WTSPQVIKETHKPLGDWSYAYMQ 563 WTSPQVIKETHKPLGDWSYAYMQ Sbjct: 541 WTSPQVIKETHKPLGDWSYAYMQ 563 >gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] Length = 503 Score = 1024 bits (2647), Expect = 0.0 Identities = 503/503 (100%), Positives = 503/503 (100%) Query: 61 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP Sbjct: 1 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 60 Query: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL Sbjct: 61 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 120 Query: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML Sbjct: 121 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 180 Query: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ Sbjct: 181 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 240 Query: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL Sbjct: 241 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 300 Query: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK Sbjct: 301 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 360 Query: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG Sbjct: 361 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 420 Query: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR Sbjct: 421 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 480 Query: 541 WTSPQVIKETHKPLGDWSYAYMQ 563 WTSPQVIKETHKPLGDWSYAYMQ Sbjct: 481 WTSPQVIKETHKPLGDWSYAYMQ 503 >gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] Length = 512 Score = 156 bits (394), Expect = 5e-38 Identities = 137/467 (29%), Positives = 217/467 (46%), Gaps = 32/467 (6%) Query: 98 DKSLLNKAIEAALAARKE---WDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 154 DK ++KA+EAA A + W R ++ + AD++ R A + A + GK Sbjct: 67 DKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDR-ATLAALETMDTGKP 125 Query: 155 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 212 + A I R+ A +A +++G+ ++P N + E G AI+P+NF Sbjct: 126 FLHAFFIDLEGCIRTLRYFAGWADKIQGK---TIPTDDNVVCFTRHEPIGVCGAITPWNF 182 Query: 213 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271 + APAL GN ++ KP++ L + + +++EAG PP ++ VP GP G Sbjct: 183 PLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGA 242 Query: 272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 331 ++S + I FTGS K L K+ A R+ E GGKN V AD++ Sbjct: 243 AISSHPQINKIAFTGSTEVGK-LVKEAASR----SNLKRVTLELGGKNPCIVCADADLDL 297 Query: 332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391 V + F GQ C+A SR++V ++ + R +E + VGDP D T Sbjct: 298 AVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPF-DVKTEQGPQ 356 Query: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 451 ID K F +I + +E + + GG + G F++P + I KEEIFGP Sbjct: 357 IDQKQFDKILELIESGKKE-GAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGP 415 Query: 452 VLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 509 V P K+K +++ ++T YGLT AVF+++ D + L +G +IN Sbjct: 416 -----VQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALE--SGTVWIN-- 466 Query: 510 STGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGD 556 ++ Q PFGG + SG N + G + + +T +K LGD Sbjct: 467 CYNALYAQAPFGGFKMSG-NGRELGEYALAEYTE---VKTVTIKLGD 509 >gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] Length = 501 Score = 153 bits (386), Expect = 5e-37 Identities = 129/444 (29%), Positives = 207/444 (46%), Gaps = 28/444 (6%) Query: 98 DKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 154 DK ++KA++AA A + W ++R ++ K AD++ R ++M G GK Sbjct: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG-GKL 114 Query: 155 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 212 A ++ A I R+ A +A +++G+ ++P N Y E G I P+NF Sbjct: 115 YSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWNF 171 Query: 213 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271 + PAL GN V+ KP++ L + V +++EAG PP ++ VP GP G Sbjct: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231 Query: 272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 331 ++S + + FTGS K L K+ A R+ E GGK+ V AD+++ Sbjct: 232 AISSHMDIDKVAFTGSTEVGK-LIKEAAGK----SNLKRVTLELGGKSPCIVLADADLDN 286 Query: 332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391 V F + GQ C A SR++V S++ + R +E + +G+P G Sbjct: 287 AVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGPQ 345 Query: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 451 ID + + +I +E + + GG + GYFV+P + + + I KEEIFGP Sbjct: 346 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGP 404 Query: 452 VLSVYVYP--DDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 509 V + + DD K + T YGL+ VF++D D + L+ AG ++N Sbjct: 405 VQQIMKFKSLDDVIKRA-----NNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN-- 455 Query: 510 STGSIVGQQPFGGARASGTNDKPG 533 G + Q PFGG + SG + G Sbjct: 456 CYGVVSAQCPFGGFKMSGNGRELG 479 >gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] Length = 518 Score = 150 bits (379), Expect = 3e-36 Identities = 125/458 (27%), Positives = 220/458 (48%), Gaps = 36/458 (7%) Query: 88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 147 G +A F + + +N A++ A AA K W K +R +I L+AA ++ R EI Sbjct: 61 GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR-EREDEIATME 119 Query: 148 MVGQGKTVIQA--EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVA 205 + GK++ +A +ID + + ++++ A A + G+ I +P + R G Sbjct: 120 CINNGKSIFEARLDIDISWQCLEYY---AGLAASMAGEH-IQLPGGSFGYTRREPLGVCV 175 Query: 206 AISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA 264 I +N+ + APAL GN +++KPS +++ + I EAG+PP + V Sbjct: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235 Query: 265 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 324 G G + + ++FTGSVPT + + A+ + + E GGK+ + Sbjct: 236 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP------VTLELGGKSPLIIF 288 Query: 325 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDF 384 D+ + V G L + F GQ C +R++V + + ++++ RIK+GDP + Sbjct: 289 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLE- 347 Query: 385 GTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG--------KCDDSVGYFVEPCIVES 436 T +I+ R+ +++ A+ +L GG K D GY++ PC++ + Sbjct: 348 DTRMGPLINRPHLERVLGFVKVAKEQ-GAKVLCGGDIYVPEDPKLKD--GYYMRPCVLTN 404 Query: 437 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 496 +KEEIFGPV+S+ + D E L+ + TT +GL VF++D +Q A +V Sbjct: 405 CRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGLAAGVFTRD---IQRAHRV 458 Query: 497 LRN-AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533 + AG +IN+ + + + PFGG + SG + G Sbjct: 459 VAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG 494 >gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] Length = 518 Score = 148 bits (374), Expect = 1e-35 Identities = 125/454 (27%), Positives = 217/454 (47%), Gaps = 28/454 (6%) Query: 88 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 144 G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R Sbjct: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122 Query: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202 +++ G GK +QA +I FR+ A +A ++ G +++P + + E G Sbjct: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178 Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261 I P+NF + APAL GN V+ KP++ L++ + +++EAG PP +I Sbjct: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINI 238 Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321 +P GP G + S + I FTGS K + + ++ R+ E GGK+ + Sbjct: 239 LPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS-----NLKRVTLELGGKSPN 293 Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381 + AD++ V + F GQ C+A SR++V S++ + R +E R VG P Sbjct: 294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 353 Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441 D T ID K + +I + ++ + + + GGK G+F+EP + + Sbjct: 354 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 411 Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499 I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++ Sbjct: 412 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 465 Query: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533 AG +IN ++ Q PFGG + SG + G Sbjct: 466 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 496 >gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] Length = 517 Score = 139 bits (351), Expect = 5e-33 Identities = 119/454 (26%), Positives = 213/454 (46%), Gaps = 28/454 (6%) Query: 88 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 144 G + D++ +++A++AA A + W ++R ++ + AD++ R + Sbjct: 62 GEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDR-VYLA 120 Query: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202 + + GK ++ E+I +R+ A +A + G+ ++P + E G Sbjct: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK---TIPMDGQHFCFTRHEPVG 177 Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261 I P+NF + APAL GN V+ K ++ L++ + +++EAG PP ++ Sbjct: 178 VCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNI 237 Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321 + GP G + + + FTGS HL ++ A + + R+ E GGK+ Sbjct: 238 ITGYGPTAGAAIAQHVDVDKVAFTGSTEV-GHLIQKAAGDSN----LKRVTLELGGKSPS 292 Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381 V AD+E V + F GQ C A SR +V S++ + R +E+ + KVG+P Sbjct: 293 IVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPF 352 Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441 E T +D + F R+ +++ + +L GG+ G+F++P + Sbjct: 353 E-LDTQQGPQVDKEQFERVLGYIQLGQKE-GAKLLCGGERFGERGFFIKPTVFGGVQDDM 410 Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499 I KEEIFGPV ++ K+K+ ++V+ + T YGL AVF++D D T+ L+ Sbjct: 411 RIAKEEIFGPVQPLF-----KFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQ- 464 Query: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533 AG ++N + + PFGG + SG + G Sbjct: 465 -AGTVWVN--TYNIVTCHTPFGGFKESGNGRELG 495 >gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo sapiens] Length = 517 Score = 137 bits (346), Expect = 2e-32 Identities = 122/454 (26%), Positives = 206/454 (45%), Gaps = 28/454 (6%) Query: 88 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 144 G + + DK ++KA++AA AA + W + R ++ + AD++ R + Sbjct: 62 GEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDR-TYLA 120 Query: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202 A + GK + + + ++ R+ A +A + G+ ++P + Y E G Sbjct: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK---TIPIDGDFFSYTRHEPVG 177 Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261 I P+NF + PAL GNVV+ K ++ L + V +++EAG PP ++ Sbjct: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237 Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321 VP GP G + S E + + FTGS + + QVA R+ E GGK+ + Sbjct: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVI--QVAAGSS---NLKRVTLELGGKSPN 292 Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381 + AD++ V + F GQ C A SR +V ++ + R + VG+P Sbjct: 293 IIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPF 352 Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441 D T +D F +I ++ + + + GG D GYF++P + Sbjct: 353 -DSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR-GYFIQPTVFGDVQDGM 410 Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499 I KEEIFGPV+ + K+K ++V + ++YGL AVF++D D ++ L+ Sbjct: 411 TIAKEEIFGPVMQIL-----KFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQ- 464 Query: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533 AG ++N Q PFGG + SG+ + G Sbjct: 465 -AGTVWVNCYDV--FGAQSPFGGYKMSGSGRELG 495 >gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] Length = 422 Score = 137 bits (344), Expect = 3e-32 Identities = 114/417 (27%), Positives = 199/417 (47%), Gaps = 25/417 (5%) Query: 122 ADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELE 181 ++R ++ K AD++ R +++ G GK +QA +I FR+ A +A ++ Sbjct: 4 SERGRLLDKLADLVERDRAVLATMESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIH 62 Query: 182 GQQPISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTA 238 G +++P + + E G I P+NF + APAL GN V+ KP++ Sbjct: 63 G---MTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQT 119 Query: 239 MLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298 L++ + +++EAG PP +I +P GP G + S + I FTGS K + + Sbjct: 120 PLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAA 179 Query: 299 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 358 ++ R+ E GGK+ + + AD++ V + F GQ C+A SR++V Sbjct: 180 GRS-----NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 234 Query: 359 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418 S++ + R +E R VG P D T ID K + +I + ++ + + + G Sbjct: 235 SIYEEFVRRSVERAKRRVVGSPF-DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECG 292 Query: 419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSY 476 GK G+F+EP + + I KEEIFGPV + ++K ++++ + + + Sbjct: 293 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDF 347 Query: 477 GLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533 GL AVF+ D + + ++ AG +IN ++ Q PFGG + SG + G Sbjct: 348 GLVAAVFTNDINKALTVSSAMQ--AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 400 >gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] Length = 487 Score = 135 bits (341), Expect = 8e-32 Identities = 114/437 (26%), Positives = 198/437 (45%), Gaps = 24/437 (5%) Query: 99 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 158 K + A++AA A W + +R+++ + AD+L A++ QGKT+ A Sbjct: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102 Query: 159 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 218 + FRF A ++ + R G ISP+N Sbjct: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162 Query: 219 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 277 APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S Sbjct: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222 Query: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337 + I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+ Sbjct: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276 Query: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 397 RS+F G+ C SR++V S++ + R +E + KVG P++ A+I Sbjct: 277 RSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL-VSIGALISKAHL 335 Query: 398 ARIKKWLEHARSSPSLTILAGGKCD-------DSVGYFVEPCIVESKDPQEPIMKEEIFG 450 +++ +++ A + I G D + GYF+ P ++ + M EEIFG Sbjct: 336 EKVRSYVKRALAE-GAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394 Query: 451 PVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510 PV V P D +E ++ ++ YGL V+S + V K L+ +G + N Sbjct: 395 PV--TCVVPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWL 449 Query: 511 TGSIVGQQPFGGARASG 527 + PFGG ++SG Sbjct: 450 IREL--NLPFGGMKSSG 464 >gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sapiens] Length = 923 Score = 135 bits (339), Expect = 1e-31 Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 29/451 (6%) Query: 88 GHKVAKFCYADKSLLNKAIEAALAARK--EWDLKPIADRAQIFLKAADMLSGPRRAEILA 145 G + K YA + ++KA+ AA A + EW +R ++ + AD+L + E+ Sbjct: 468 GSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLE-ENQEELAT 526 Query: 146 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PISVPPSTNSTVYRGLE--G 202 + G A + FR+ A + +++G PI+ + + E G Sbjct: 527 IEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLG 586 Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261 A I P+N+ + A L GN ++ KP+ L + + +AG P +I Sbjct: 587 VCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINI 646 Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321 +P G + G ++ + + FTGS P K + K A + +++ E GGK+ Sbjct: 647 IPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVS-----NLKKVSLELGGKSPL 701 Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381 + +++ V + + F G+ C A RL+V S+ + R++EE ++K+GDP Sbjct: 702 IIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPL 761 Query: 382 E---DFGTFFSAVIDAKSFARIKKWLEHARS--SPSLTILAGGKCDDSVGYFVEPCIVES 436 + D G A ++K L++ + T++ GG+ G+F+EP + Sbjct: 762 DRSTDHG-------PQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTD 814 Query: 437 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 496 + + KEE FGP++ + + + LQ +S T YGL VF++D + ++ Sbjct: 815 VEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANS-TEYGLASGVFTRDINKAMYVSEK 873 Query: 497 LRNAAGNFYINDKSTGSIVGQQPFGGARASG 527 L AG +IN + + PFGG + SG Sbjct: 874 LE--AGTVFINTYNKTDVAA--PFGGVKQSG 900 >gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sapiens] Length = 902 Score = 127 bits (318), Expect = 4e-29 Identities = 112/446 (25%), Positives = 194/446 (43%), Gaps = 19/446 (4%) Query: 88 GHKVAKFCYADKSLLNKAIEAALAARKE--WDLKPIADRAQIFLKAADMLSGPRRAEILA 145 G + + A + ++KA+ AA A + W DR ++ + AD++ + E+ Sbjct: 447 GSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLME-QHQEELAT 505 Query: 146 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PIS-VPPSTNSTVYRGLE-G 202 + G A I FR+ A + +++G PI+ P+ N T+ R G Sbjct: 506 IEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVG 565 Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261 I P+N+ + + A L GN V+ KP+ L + + +AG+P ++ Sbjct: 566 VCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNV 625 Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321 +P G L G ++ + I FTGS KH+ K A +++ E GGK+ Sbjct: 626 LPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA-----ISNVKKVSLELGGKSPL 680 Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381 + D+ V + S F G+ C A RL+V S+ + R++EE ++KVG+P Sbjct: 681 IIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPL 740 Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441 D T ++ ++ +H T++ GG G+F EP + + Sbjct: 741 -DRDTDHGPQNHHAHLVKLMEYCQHG-VKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHM 798 Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAA 501 I KEE FGPV+ + + D L ++ T +GL VF++D + + L+ A Sbjct: 799 FIAKEESFGPVMIISRFADGDLDAVLSRANA-TEFGLASGVFTRDINKALYVSDKLQ--A 855 Query: 502 GNFYINDKSTGSIVGQQPFGGARASG 527 G ++N + + PFGG + SG Sbjct: 856 GTVFVNTYNKTDVAA--PFGGFKQSG 879 >gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sapiens] Length = 539 Score = 113 bits (283), Expect = 4e-25 Identities = 119/476 (25%), Positives = 205/476 (43%), Gaps = 45/476 (9%) Query: 80 YQVSPFNHGHKVAKFCYADKSLLNKAIEAALA--------ARKEWDLK---PIADRAQIF 128 Y S G + +C A+ + + +A++A AR+ W + P R +I Sbjct: 55 YNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIV 114 Query: 129 LKAADMLSGPRRAEILAKTM-VGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPIS 187 + D L + ++L + + GK +++ + E +D YAV L Sbjct: 115 RQIGDALR--EKIQVLGSLVSLEMGKILVEG-VGEVQEYVDI----CDYAVGLSRMIGGP 167 Query: 188 VPPSTNSTVYRGLE-----GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLA 241 + PS S + +E G V I+ FNF A+ G + GNV LWK + T L Sbjct: 168 ILPSERSG-HALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLI 226 Query: 242 SYAVYRILR---EAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298 S AV +I+ E P I + G G + E + ++FTGS K + V Sbjct: 227 SVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV 286 Query: 299 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 358 + F R E GG N AD+ VV L +A GQ+C+ RL++ Sbjct: 287 QER------FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHE 340 Query: 359 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418 S+ ++ RL + +++I+VG+P D + + ++ + +E A+ T++ G Sbjct: 341 SIHDEVVNRLKKAYAQIRVGNP-WDPNVLYGPLHTKQAVSMFLGAVEEAKKEGG-TVVYG 398 Query: 419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGL 478 GK D G +VEP IV I E F P+L V+ + K +E + ++ GL Sbjct: 399 GKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKF---KNEEEVFAWNNEVKQGL 455 Query: 479 TGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIV-----GQQPFGGARASGTN 529 + ++F++D + + G +N ++G+ + G++ GG R SG++ Sbjct: 456 SSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSD 511 >gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] Length = 480 Score = 107 bits (268), Expect = 2e-23 Identities = 111/454 (24%), Positives = 197/454 (43%), Gaps = 66/454 (14%) Query: 88 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 144 G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R Sbjct: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122 Query: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202 +++ G GK +QA +I FR+ A +A ++ G +++P + + E G Sbjct: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178 Query: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261 I P+NF + APAL GN V+ KP++ L++ + +++E G Sbjct: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG-------- 230 Query: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321 ++ Q R+ E GGK+ + Sbjct: 231 -----------------------------------KLIQEAAGRSNLKRVTLELGGKSPN 255 Query: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381 + AD++ V + F GQ C+A SR++V S++ + R +E R VG P Sbjct: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315 Query: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441 D T ID K + +I + ++ + + + GGK G+F+EP + + Sbjct: 316 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 373 Query: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499 I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++ Sbjct: 374 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 427 Query: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533 AG +IN ++ Q PFGG + SG + G Sbjct: 428 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 458 >gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] Length = 433 Score = 99.4 bits (246), Expect = 8e-21 Identities = 106/430 (24%), Positives = 178/430 (41%), Gaps = 64/430 (14%) Query: 99 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 158 K + A++AA A W + +R+++ + AD+L A++ QGKT+ A Sbjct: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102 Query: 159 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 218 + FRF A ++ + R G ISP+N Sbjct: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162 Query: 219 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 277 APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S Sbjct: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222 Query: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337 + I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+ Sbjct: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276 Query: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 397 RS+F + R YV R L E ++I G+ + Sbjct: 277 RSSF-------ANQVRSYVK---------RALAEGAQIWCGEGVDKL------------- 307 Query: 398 ARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYV 457 S P+ + GYF+ P ++ + M EEIFGPV V Sbjct: 308 -----------SLPA---------RNQAGYFMLPTVITDIKDESCCMTEEIFGPV--TCV 345 Query: 458 YPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQ 517 P D +E ++ ++ YGL V+S + V K L+ +G + N + Sbjct: 346 VPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWLIREL--N 400 Query: 518 QPFGGARASG 527 PFGG ++SG Sbjct: 401 LPFGGMKSSG 410 >gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo sapiens] Length = 535 Score = 98.2 bits (243), Expect = 2e-20 Identities = 105/431 (24%), Positives = 192/431 (44%), Gaps = 28/431 (6%) Query: 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 161 A+ AA A W +R+ + K +++ + + LA+ + + GK + +A EI Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158 Query: 162 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 220 +A +++F A+ + G + + V + G A I+P+NF +A+ Sbjct: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215 Query: 221 GAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA---DGPLFGDTVTSSE 277 GA G V+ KP++ ++ A+ + +AG+P + +P + G+ + + Sbjct: 216 GAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDP 275 Query: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337 + I+FTGS T K L A ++ R ++ E GG V SA+V+ V+G + Sbjct: 276 LVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVFDSANVDQAVAGAM 329 Query: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAEDFGTFFSAVIDAKS 396 S F GQ C ++ V + E + ++VG+ E+ GT +I+ K+ Sbjct: 330 ASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE-GTTQGPLINEKA 388 Query: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456 +++K + A S T++ GGK F EP ++ + EE FGP+ V Sbjct: 389 VEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVI 447 Query: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516 + D +E + + ++ GL G +SQD + + L G +N+ S+ Sbjct: 448 KF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGMVGVNEGLISSV-- 500 Query: 517 QQPFGGARASG 527 + PFGG + SG Sbjct: 501 ECPFGGVKQSG 511 >gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo sapiens] Length = 548 Score = 89.4 bits (220), Expect = 8e-18 Identities = 105/444 (23%), Positives = 193/444 (43%), Gaps = 41/444 (9%) Query: 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 161 A+ AA A W +R+ + K +++ + + LA+ + + GK + +A EI Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158 Query: 162 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 220 +A +++F A+ + G + + V + G A I+P+NF +A+ Sbjct: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215 Query: 221 GAPALMGNVVLWKPSDTAMLASYAVYRILR-------------EAGLPPNIIQFVPA--- 264 GA G V+ KP++ ++ A+ + + +AG+P + +P Sbjct: 216 GAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRK 275 Query: 265 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 324 + G+ + + + I+FTGS T K L A ++ R ++ E GG V Sbjct: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVF 329 Query: 325 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAED 383 SA+V+ V+G + S F GQ C ++ V + E + ++VG+ E+ Sbjct: 330 DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 389 Query: 384 FGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPI 443 GT +I+ K+ +++K + A S T++ GGK F EP ++ + Sbjct: 390 -GTTQGPLINEKAVEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLC 447 Query: 444 MKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGN 503 EE FGP+ V + D +E + + ++ GL G +SQD + + L G Sbjct: 448 THEETFGPLAPVIKF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGM 502 Query: 504 FYINDKSTGSIVGQQPFGGARASG 527 +N+ S+ + PFGG + SG Sbjct: 503 VGVNEGLISSV--ECPFGGVKQSG 524 >gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] Length = 535 Score = 84.0 bits (206), Expect = 3e-16 Identities = 97/396 (24%), Positives = 169/396 (42%), Gaps = 26/396 (6%) Query: 97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVI 156 A K+ ++ AI + A W + R Q+ L+ ++ + EI + QGKT+ Sbjct: 74 ATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLK-EIAKLITLEQGKTLA 132 Query: 157 QAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIG 216 AE D L + G+ S+ + YR G A I+PFNF A+ Sbjct: 133 DAEGDVFRGL-QVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191 Query: 217 GNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTS 275 A++ GN L KPS+ A+ + ++L+++G P + + + + Sbjct: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAV-NFICD 250 Query: 276 SEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSG 335 + I+F GS ++++++ +++ R+ G KN V A+ E+ ++ Sbjct: 251 HPDIKAISFVGSNKAGEYIFERGSRH------GKRVQANMGAKNHGVVMPDANKENTLNQ 304 Query: 336 TLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS---RIKVGD-PAEDFGTFFSAV 391 + +AF GQ+C A S + + L EH+ R+ GD P D G + Sbjct: 305 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPE--LVEHAKNLRVNAGDQPGADLGP----L 358 Query: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSV---GYFVEPCIVESKDPQEPIMKEEI 448 I ++ R+ ++ + +L G K G FV P I+ + P KEEI Sbjct: 359 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI 418 Query: 449 FGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFS 484 FGPVL V + E +Q+V++ YG A+F+ Sbjct: 419 FGPVL--VVLETETLDEAIQIVNN-NPYGNGTAIFT 451 >gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] Length = 453 Score = 78.6 bits (192), Expect = 1e-14 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%) Query: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159 S +++A++ A AA +P+ R Q L+A L + E++ K A Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60 Query: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212 + +++ + + E +P+ P T ++ G V I PFN Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 Query: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269 T + GA A GN V+ KPS+ + + + I+ + L P I VP L Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177 Query: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329 E I +TGS K + A++L + E GGK+ +V ++ D+ Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225 Query: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387 + F GQ C A + S+ QI +L + D + D+G Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284 Query: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447 +I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334 Query: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507 IFGPVL + +E +Q ++ L +FS + V+++ + ++G N Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389 Query: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533 D + PFGG SG G Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415 >gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] Length = 453 Score = 78.6 bits (192), Expect = 1e-14 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%) Query: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159 S +++A++ A AA +P+ R Q L+A L + E++ K A Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60 Query: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212 + +++ + + E +P+ P T ++ G V I PFN Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 Query: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269 T + GA A GN V+ KPS+ + + + I+ + L P I VP L Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177 Query: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329 E I +TGS K + A++L + E GGK+ +V ++ D+ Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225 Query: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387 + F GQ C A + S+ QI +L + D + D+G Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284 Query: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447 +I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334 Query: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507 IFGPVL + +E +Q ++ L +FS + V+++ + ++G N Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389 Query: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533 D + PFGG SG G Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415 >gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] Length = 453 Score = 78.6 bits (192), Expect = 1e-14 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%) Query: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159 S +++A++ A AA +P+ R Q L+A L + E++ K A Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60 Query: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212 + +++ + + E +P+ P T ++ G V I PFN Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 Query: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269 T + GA A GN V+ KPS+ + + + I+ + L P I VP L Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177 Query: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329 E I +TGS K + A++L + E GGK+ +V ++ D+ Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225 Query: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387 + F GQ C A + S+ QI +L + D + D+G Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284 Query: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447 +I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334 Query: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507 IFGPVL + +E +Q ++ L +FS + V+++ + ++G N Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389 Query: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533 D + PFGG SG G Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415 >gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] Length = 468 Score = 71.2 bits (173), Expect = 2e-12 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%) Query: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257 G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP Sbjct: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157 Query: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313 + Q V GP +T EH I FTGS K + A++L + Sbjct: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209 Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373 E GGKN +V + D ++V + + GQ C A + + ++ L + Sbjct: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269 Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433 R DP +I+ K F R++ L R + GG+ D+S Y + P + Sbjct: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320 Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493 + EP+M+EEIFGP+L + E ++ ++ L FS VV+ Sbjct: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377 Query: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527 + + ++G F ND + PFGG ASG Sbjct: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409 >gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] Length = 431 Score = 71.2 bits (173), Expect = 2e-12 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%) Query: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257 G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP Sbjct: 69 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 120 Query: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313 + Q V GP +T EH I FTGS K + A++L + Sbjct: 121 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 172 Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373 E GGKN +V + D ++V + + GQ C A + + ++ L + Sbjct: 173 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 232 Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433 R DP +I+ K F R++ L R + GG+ D+S Y + P + Sbjct: 233 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 283 Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493 + EP+M+EEIFGP+L + E ++ ++ L FS VV+ Sbjct: 284 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 340 Query: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527 + + ++G F ND + PFGG ASG Sbjct: 341 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 372 >gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] Length = 468 Score = 71.2 bits (173), Expect = 2e-12 Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%) Query: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257 G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP Sbjct: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157 Query: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313 + Q V GP +T EH I FTGS K + A++L + Sbjct: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209 Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373 E GGKN +V + D ++V + + GQ C A + + ++ L + Sbjct: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269 Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433 R DP +I+ K F R++ L R + GG+ D+S Y + P + Sbjct: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320 Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493 + EP+M+EEIFGP+L + E ++ ++ L FS VV+ Sbjct: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377 Query: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527 + + ++G F ND + PFGG ASG Sbjct: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409 >gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1 [Homo sapiens] Length = 802 Score = 64.3 bits (155), Expect = 3e-10 Identities = 115/472 (24%), Positives = 188/472 (39%), Gaps = 64/472 (13%) Query: 88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 147 G +A A + A+EAA A K W P RAQ + A+++ +R ++ Sbjct: 65 GENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLES 124 Query: 148 MV-GQG-KTVIQAEIDAAAELIDFFRFNAKYAVE-LEGQQPISVPPSTNSTVYRGLEGFV 204 +V G+ + V ++ A +L+ + A E L G +P+ G + Sbjct: 125 LVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM---------------GVI 169 Query: 205 AAISP--FNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFV 262 I P F+F + + A A+ VV P A A + ++ E G P I+ + Sbjct: 170 GLILPPTFSFLEMMWRICPALAVGCTVVALVP--PASPAPLLLAQLAGELGPFPGILNVL 227 Query: 263 PADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGEC------- 315 L + S + + F G+ + L + LAGEC Sbjct: 228 SGPASLV-PILASQPGIRKVAFCGAPEEGRALRRS-------------LAGECAELGLAL 273 Query: 316 GGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRI 375 G ++ + +ADV+S V G + +A+ G RL + S+W + RL E R+ Sbjct: 274 GTESLLLLTDTADVDSAVEGVVDAAWSDRG---PGGLRLLIQESVWDEAMRRLQERMGRL 330 Query: 376 KVG---DPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPC 432 + G D A D G +A D +++++ A+S + AG S F P Sbjct: 331 RSGRGLDGAVDMGARGAAACDL-----VQRFVREAQSQGAQVFQAGDV--PSERPFYPPT 383 Query: 433 IVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQE 492 +V + P P + E+ PV V P KE L LV + T G + +V+S+ E Sbjct: 384 LVSNLPPASPCAQVEVPWPV--VVASPFRTAKEAL-LVANGTPRGGSASVWSERLGQALE 440 Query: 493 ATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSP 544 L+ G +IN + G P GG + SG + GGP + + P Sbjct: 441 LGYGLQ--VGTVWIN--AHGLRDPSVPTGGCKESGCS-WHGGPDGLYEYLRP 487 >gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] Length = 485 Score = 63.5 bits (153), Expect = 5e-10 Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%) Query: 219 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 276 L GA A GN V+ KPS+ + + + ++L P + Q ++ +G + T Sbjct: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175 Query: 277 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 336 + I +TG+ K + + A++L + E GGK+ ++ + D++ V Sbjct: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229 Query: 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 396 + GQ C A + SL QI ++ E G+ ++ + +I+ + Sbjct: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287 Query: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456 F RI LE + I GG+ D++ Y + P ++ DP+ +M+EEIFGP+L Sbjct: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338 Query: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516 + P E + ++ L VFS + +++ + ++G ND + Sbjct: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395 Query: 517 QQPFGGARASG 527 PFGG +SG Sbjct: 396 SFPFGGVGSSG 406 >gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] Length = 508 Score = 63.5 bits (153), Expect = 5e-10 Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%) Query: 219 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 276 L GA A GN V+ KPS+ + + + ++L P + Q ++ +G + T Sbjct: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175 Query: 277 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 336 + I +TG+ K + + A++L + E GGK+ ++ + D++ V Sbjct: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229 Query: 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 396 + GQ C A + SL QI ++ E G+ ++ + +I+ + Sbjct: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287 Query: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456 F RI LE + I GG+ D++ Y + P ++ DP+ +M+EEIFGP+L Sbjct: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338 Query: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516 + P E + ++ L VFS + +++ + ++G ND + Sbjct: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395 Query: 517 QQPFGGARASG 527 PFGG +SG Sbjct: 396 SFPFGGVGSSG 406 >gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] Length = 385 Score = 62.8 bits (151), Expect = 8e-10 Identities = 100/381 (26%), Positives = 156/381 (40%), Gaps = 60/381 (15%) Query: 202 GFVAAISPFNF----TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257 G V I+P+N+ T + L GA A G+ V+ KPS+ S ++L E LP Sbjct: 25 GLVLIIAPWNYPLNLTLV--LLVGALAA-GSCVVLKPSEI----SQGTEKVLAEV-LPQY 76 Query: 258 IIQF---VPADGPLFGDTVTSSEH-LCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313 + Q V GP +T EH L I FTGS K + ++L + Sbjct: 77 LDQSCFAVVLGGPQ--ETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTP------VTL 128 Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373 E GGKN +V + D ++V + + GQ C A + + ++ L + Sbjct: 129 ELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 188 Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433 R DP +I+ K F R++ L R + GG+ ++S Y + P + Sbjct: 189 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSNESDRY-IAPTV 239 Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSY------GLTGAVFSQDK 487 + EP+M+EEIFGP+L + +Q VD + L FS Sbjct: 240 LVDVQETEPVMQEEIFGPILPIV---------NVQSVDEAIKFINRQEKPLALYAFSNSS 290 Query: 488 DVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGG------PHY---I 538 VV + + R ++G+F N+ T + PFGG SG G H+ + Sbjct: 291 QVVNQMLE--RTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCL 348 Query: 539 LRWTSPQVIKETH-KPLGDWS 558 L + + +KE H P DW+ Sbjct: 349 LAPSGLEKLKEIHYPPYTDWN 369 >gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] Length = 385 Score = 62.8 bits (151), Expect = 8e-10 Identities = 100/381 (26%), Positives = 156/381 (40%), Gaps = 60/381 (15%) Query: 202 GFVAAISPFNF----TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257 G V I+P+N+ T + L GA A G+ V+ KPS+ S ++L E LP Sbjct: 25 GLVLIIAPWNYPLNLTLV--LLVGALAA-GSCVVLKPSEI----SQGTEKVLAEV-LPQY 76 Query: 258 IIQF---VPADGPLFGDTVTSSEH-LCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313 + Q V GP +T EH L I FTGS K + ++L + Sbjct: 77 LDQSCFAVVLGGPQ--ETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTP------VTL 128 Query: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373 E GGKN +V + D ++V + + GQ C A + + ++ L + Sbjct: 129 ELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 188 Query: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433 R DP +I+ K F R++ L R + GG+ ++S Y + P + Sbjct: 189 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSNESDRY-IAPTV 239 Query: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSY------GLTGAVFSQDK 487 + EP+M+EEIFGP+L + +Q VD + L FS Sbjct: 240 LVDVQETEPVMQEEIFGPILPIV---------NVQSVDEAIKFINRQEKPLALYAFSNSS 290 Query: 488 DVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGG------PHY---I 538 VV + + R ++G+F N+ T + PFGG SG G H+ + Sbjct: 291 QVVNQMLE--RTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCL 348 Query: 539 LRWTSPQVIKETH-KPLGDWS 558 L + + +KE H P DW+ Sbjct: 349 LAPSGLEKLKEIHYPPYTDWN 369 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.135 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,416,913 Number of Sequences: 37866 Number of extensions: 1037155 Number of successful extensions: 2175 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 32 Number of HSP's successfully gapped in prelim test: 4 Number of HSP's that attempted gapping in prelim test: 2067 Number of HSP's gapped (non-prelim): 40 length of query: 563 length of database: 18,247,518 effective HSP length: 107 effective length of query: 456 effective length of database: 14,195,856 effective search space: 6473310336 effective search space used: 6473310336 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.