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Search of human proteins with 25777732
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor
[Homo sapiens]
(517 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 1045 0.0
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 770 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 709 0.0
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 702 0.0
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 676 0.0
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 624 e-179
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 623 e-178
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 457 e-129
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 453 e-127
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 370 e-102
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 332 4e-91
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 273 3e-73
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 257 2e-68
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 248 1e-65
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 206 3e-53
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 197 1e-50
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 176 6e-44
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 144 1e-34
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 144 1e-34
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 144 1e-34
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 139 8e-33
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 137 2e-32
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 137 2e-32
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 137 2e-32
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 129 8e-30
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 129 8e-30
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 127 2e-29
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 127 2e-29
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 127 2e-29
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 122 6e-28
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 1045 bits (2701), Expect = 0.0
Identities = 517/517 (100%), Positives = 517/517 (100%)
Query: 1 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS 60
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
Sbjct: 1 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS 60
Query: 61 TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA 120
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
Sbjct: 61 TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA 120
Query: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG 180
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
Sbjct: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG 180
Query: 181 QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG 240
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
Sbjct: 181 QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG 240
Query: 241 FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM 300
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
Sbjct: 241 FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM 300
Query: 301 DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP 360
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
Sbjct: 301 DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP 360
Query: 361 QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP 420
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
Sbjct: 361 QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP 420
Query: 421 VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS 480
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
Sbjct: 421 VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS 480
Query: 481 PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 517
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
Sbjct: 481 PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 517
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 770 bits (1989), Expect = 0.0
Identities = 376/517 (72%), Positives = 437/517 (84%)
Query: 1 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS 60
MLR A L R ++ A+P+P P++ NQ+FINNEW DAVS+KTFPTVNP+
Sbjct: 1 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT 60
Query: 61 TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA 120
TGEVI VAEGD+ DVD+AVKAAR AF+LGSPWRRMDAS RGRLLNRLADL+ERDR YLA
Sbjct: 61 TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLA 120
Query: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG 180
+LETLDNGKP+ SY +DLD V+K RY+AGWADK+HGKTIP+DG F +TRHEPVGVCG
Sbjct: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG 180
Query: 181 QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG 240
QIIPWNFPL+MQ WKL PALATGN VVMKVAEQTPL+ALY+A+LIKEAGFPPGVVNI+ G
Sbjct: 181 QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG 240
Query: 241 FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM 300
+GPTAGAAIA H DVDKVAFTGSTE+G +IQ AAG SNLKRVTLELGGKSP+I+++DADM
Sbjct: 241 YGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM 300
Query: 301 DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP 360
+ AVEQ H ALFFN GQCCCAGSRTFV+E IY+EF+ER+V +AK R VGNPF+ T+QGP
Sbjct: 301 EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP 360
Query: 361 QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP 420
QVD+ QF+++LGYI G++EGAKLLCGG +RG+FI+PTVFG VQD M IAKEEIFGP
Sbjct: 361 QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP 420
Query: 421 VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS 480
V + KFK IEEVV RANN+ YGLAAAVFT+DLDKA Y +QALQAGTVWVN Y++ +
Sbjct: 421 VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT 480
Query: 481 PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 517
PFGG+K SG+GRELGE GL+AYTEVKTVT+KVPQKNS
Sbjct: 481 PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS 517
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 709 bits (1829), Expect = 0.0
Identities = 335/498 (67%), Positives = 410/498 (82%)
Query: 20 AATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKA 79
A+ +P+P E+ +IFINNEW ++ S + FP NP+TGE +C+V E DK D+DKA
Sbjct: 21 ASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKA 80
Query: 80 VKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDL 139
V+AAR AF LGS WRRMDAS RGRLL++LADL+ERDR LA +E+L+ GKP++ ++ VDL
Sbjct: 81 VQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDL 140
Query: 140 DMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPA 199
V+K RYYAGWADK HG TIP+DGD+F++TRHEP+GVCGQIIPWNFPLLM AWK+ PA
Sbjct: 141 QGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPA 200
Query: 200 LATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVA 259
L GN VV+K AEQTPL+ALY+ LIKEAGFPPGV+NI+PG+GPTAGAAIASH +DK+A
Sbjct: 201 LCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIA 260
Query: 260 FTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCC 319
FTGSTE+G++IQ AAG SNLKRVTLELGGKSPNII +DAD+D+AVEQAH +FFNQGQCC
Sbjct: 261 FTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCC 320
Query: 320 CAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQ 379
AGSR FV+E IY+EFV RSV RAK RVVG+PFD TEQGPQ+D+ Q+ KIL I +G
Sbjct: 321 TAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVA 380
Query: 380 EGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANN 439
EGAKL CGG +G+FI+PTVF +V D M IAKEEIFGPV +IL+FKT++EV+ RANN
Sbjct: 381 EGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANN 440
Query: 440 STYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGL 499
S +GL AAVFT D++KA +S A+QAGTVW+NCY+ AQSPFGG+KMSG+GRE+GE+GL
Sbjct: 441 SDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGL 500
Query: 500 QAYTEVKTVTVKVPQKNS 517
+ Y+EVKTVTVK+PQKNS
Sbjct: 501 REYSEVKTVTVKIPQKNS 518
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 702 bits (1812), Expect = 0.0
Identities = 341/501 (68%), Positives = 408/501 (81%)
Query: 17 LSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDV 76
+S++ T +P ++ +IFINNEWHD+VS K FP NP+T E +CQV EGDKEDV
Sbjct: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60
Query: 77 DKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYL 136
DKAVKAAR AFQ+GSPWR MDAS RGRLL +LADLIERDR LA +E+++ GK Y +YL
Sbjct: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120
Query: 137 VDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKL 196
DL +K LRY AGWADK G+TIPIDG+FF+YTRHEP+GVCGQIIPWNFPL+M WK+
Sbjct: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180
Query: 197 GPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVD 256
GPAL+ GN VV+K AEQTPLTAL+VA+LIKEAGFPPGVVNIVPG+GPTAGAAI+SH D+D
Sbjct: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240
Query: 257 KVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQG 316
KVAFTGSTE+G++I+ AAG SNLKRVTLELGGKSP I+++DAD+D AVE AH +F++QG
Sbjct: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300
Query: 317 QCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINT 376
QCC A SR FV+E IYDEFV RSV RAK ++GNP QGPQ+D+ Q+ KIL I +
Sbjct: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360
Query: 377 GKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGR 436
GK+EGAKL CGGG ++GYF+QPTVF +V D M IAKEEIFGPV QI+KFK++++V+ R
Sbjct: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420
Query: 437 ANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGE 496
ANN+ YGL+A VFTKD+DKA +S ALQAGTVWVNCY V AQ PFGG+KMSG+GRELGE
Sbjct: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480
Query: 497 YGLQAYTEVKTVTVKVPQKNS 517
YG YTEVKTVTVK+ QKNS
Sbjct: 481 YGFHEYTEVKTVTVKISQKNS 501
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 676 bits (1744), Expect = 0.0
Identities = 326/493 (66%), Positives = 394/493 (79%)
Query: 24 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAA 83
A+P P + EV +IFINNEWH++ S K F T NPST E IC+V EGDK DVDKAV+AA
Sbjct: 19 ALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAA 78
Query: 84 RAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVL 143
+ AFQ GSPWRR+DA RGRLL++LADL+ERDR LAALET+D GKP++ ++ +DL+ +
Sbjct: 79 QVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCI 138
Query: 144 KCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATG 203
+ LRY+AGWADK GKTIP D + +TRHEP+GVCG I PWNFPLLM WKL PAL G
Sbjct: 139 RTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCG 198
Query: 204 NVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGS 263
N +V+K AEQTPLTALY+ +LIKEAGFPPGVVNIVPGFGPT GAAI+SH ++K+AFTGS
Sbjct: 199 NTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGS 258
Query: 264 TEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGS 323
TE+G++++ AA SNLKRVTLELGGK+P I+ +DAD+D AVE AH +FFNQGQCC A S
Sbjct: 259 TEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAAS 318
Query: 324 RTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAK 383
R FV+E +Y EFV RSV AK R VG+PFD KTEQGPQ+D+ QF KIL I +GK+EGAK
Sbjct: 319 RVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAK 378
Query: 384 LLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYG 443
L CGG D+G FI+PTVF +V D M IAKEEIFGPV ILKFK+IEEV+ RAN++ YG
Sbjct: 379 LECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYG 438
Query: 444 LAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYT 503
L AAVFTK+LDKA L+ AL++GTVW+NCY+ AQ+PFGG+KMSG+GRELGEY L YT
Sbjct: 439 LTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYT 498
Query: 504 EVKTVTVKVPQKN 516
EVKTVT+K+ KN
Sbjct: 499 EVKTVTIKLGDKN 511
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 624 bits (1608), Expect = e-179
Identities = 295/422 (69%), Positives = 357/422 (84%)
Query: 96 MDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADK 155
MDAS RGRLL++LADL+ERDR LA +E+L+ GKP++ ++ VDL V+K RYYAGWADK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 156 YHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTP 215
HG TIP+DGD+F++TRHEP+GVCGQIIPWNFPLLM AWK+ PAL GN VV+K AEQTP
Sbjct: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
Query: 216 LTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAG 275
L+ALY+ LIKEAGFPPGV+NI+PG+GPTAGAAIASH +DK+AFTGSTE+G++IQ AAG
Sbjct: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
Query: 276 SSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEF 335
SNLKRVTLELGGKSPNII +DAD+D+AVEQAH +FFNQGQCC AGSR FV+E IY+EF
Sbjct: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
Query: 336 VERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRG 395
V RSV RAK RVVG+PFD TEQGPQ+D+ Q+ KIL I +G EGAKL CGG +G
Sbjct: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
Query: 396 YFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDK 455
+FI+PTVF +V D M IAKEEIFGPV +IL+FKT++EV+ RANNS +GL AAVFT D++K
Sbjct: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
Query: 456 ANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQK 515
A +S A+QAGTVW+NCY+ AQSPFGG+KMSG+GRE+GE+GL+ Y+EVKTVTVK+PQK
Sbjct: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
Query: 516 NS 517
NS
Sbjct: 421 NS 422
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 623 bits (1606), Expect = e-178
Identities = 304/498 (61%), Positives = 374/498 (75%), Gaps = 38/498 (7%)
Query: 20 AATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKA 79
A+ +P+P E+ +IFINNEW ++ S + FP NP+TGE +C+V E DK D+DKA
Sbjct: 21 ASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKA 80
Query: 80 VKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDL 139
V+AAR AF LGS WRRMDAS RGRLL++LADL+ERDR LA +E+L+ GKP++ ++ VDL
Sbjct: 81 VQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDL 140
Query: 140 DMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPA 199
V+K RYYAGWADK HG TIP+DGD+F++TRHEP+GVCGQIIPWNFPLLM AWK+ PA
Sbjct: 141 QGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPA 200
Query: 200 LATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVA 259
L GN VV+K AEQTPL+ALY+ LIKE
Sbjct: 201 LCCGNTVVIKPAEQTPLSALYMGALIKE-------------------------------- 228
Query: 260 FTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCC 319
+G++IQ AAG SNLKRVTLELGGKSPNII +DAD+D+AVEQAH +FFNQGQCC
Sbjct: 229 ------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCC 282
Query: 320 CAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQ 379
AGSR FV+E IY+EFV RSV RAK RVVG+PFD TEQGPQ+D+ Q+ KIL I +G
Sbjct: 283 TAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVA 342
Query: 380 EGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANN 439
EGAKL CGG +G+FI+PTVF +V D M IAKEEIFGPV +IL+FKT++EV+ RANN
Sbjct: 343 EGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANN 402
Query: 440 STYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGL 499
S +GL AAVFT D++KA +S A+QAGTVW+NCY+ AQSPFGG+KMSG+GRE+GE+GL
Sbjct: 403 SDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGL 462
Query: 500 QAYTEVKTVTVKVPQKNS 517
+ Y+EVKTVTVK+PQKNS
Sbjct: 463 REYSEVKTVTVKIPQKNS 480
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 457 bits (1177), Expect = e-129
Identities = 234/480 (48%), Positives = 320/480 (66%), Gaps = 7/480 (1%)
Query: 38 QIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMD 97
Q FIN ++ DA KT+ T+NP+ G IC+V+ DVDKAV AA+ AF+ G W RM+
Sbjct: 444 QCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-WGRMN 502
Query: 98 ASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYH 157
A RGRL+ RLADL+E ++ LA +E LD+G Y ++ + M ++ RY+AGW DK
Sbjct: 503 ARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQ 562
Query: 158 GKTIPID----GDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQ 213
G TIPI+ ++T+ EP+GVC IIPWN+PL+M AWK LA GN +V+K A+
Sbjct: 563 GSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQV 622
Query: 214 TPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVA 273
TPLTAL A L +AGFP GV+NI+PG G AG ++ H D+ K+ FTGST IG+ I +
Sbjct: 623 TPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKS 682
Query: 274 AGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYD 333
SNLK+V+LELGGKSP II +D ++D AV A+FFN+G+ C A R FV+E I+D
Sbjct: 683 CAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHD 742
Query: 334 EFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAAD 393
EFV R V K +G+P D T+ GPQ + +K+L Y TG +EGA L+ GG
Sbjct: 743 EFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQR 802
Query: 394 RGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKT--IEEVVGRANNSTYGLAAAVFTK 451
G+F++PTVF DV+D M +AKEE FGP+M I KF+ I+ V+ RAN++ YGLA+ VFT+
Sbjct: 803 PGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTR 862
Query: 452 DLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511
D++KA Y+S+ L+AGTV++N Y+ +PFGG K SG G++LGE L Y + KTVT++
Sbjct: 863 DINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 453 bits (1165), Expect = e-127
Identities = 237/489 (48%), Positives = 316/489 (64%), Gaps = 7/489 (1%)
Query: 27 APNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAA 86
A N++ +Q+FI E+ DA KT T+NP+ G VICQV+ DVDKAV AA+ A
Sbjct: 412 AVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDA 471
Query: 87 FQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCL 146
F+ G W ++ A RGRL+ RLADL+E+ + LA +E LD G Y ++ + M ++
Sbjct: 472 FENGR-WGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTF 530
Query: 147 RYYAGWADKYHGKTIPID----GDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALAT 202
RY+AGW DK G TIPI+ + TR EPVGVCG IIPWN+PL+M +WK LA
Sbjct: 531 RYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAA 590
Query: 203 GNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTG 262
GN VV+K A+ TPLTAL A L +AG P GVVN++PG G G ++ H DV K+ FTG
Sbjct: 591 GNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTG 650
Query: 263 STEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAG 322
STE+G+ I + SN+K+V+LELGGKSP II +D D++ AV+ ++FFN+G+ C A
Sbjct: 651 STEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAA 710
Query: 323 SRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGA 382
R FV++ I+DEFV R V + VGNP D T+ GPQ K++ Y G +EGA
Sbjct: 711 GRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGA 770
Query: 383 KLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFK--TIEEVVGRANNS 440
L+CGG G+F +PTVF DV+D M IAKEE FGPVM I +F ++ V+ RAN +
Sbjct: 771 TLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANAT 830
Query: 441 TYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQ 500
+GLA+ VFT+D++KA Y+S LQAGTV+VN Y+ +PFGG+K SG G++LGE L
Sbjct: 831 EFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALN 890
Query: 501 AYTEVKTVT 509
Y VKTVT
Sbjct: 891 EYLRVKTVT 899
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 370 bits (949), Expect = e-102
Identities = 198/460 (43%), Positives = 283/460 (61%), Gaps = 12/460 (2%)
Query: 59 PSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTY 118
P+TG VI +++V+ AV+ A+AAF++ W + R R+L A +I
Sbjct: 58 PATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIREREDE 114
Query: 119 LAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGV 178
+A +E ++NGK + +D+D+ +CL YYAG A G+ I + G F YTR EP+GV
Sbjct: 115 IATMECINNGKS-IFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 173
Query: 179 CGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIV 238
C I WN+P + +WK PALA GN +V K + TP++AL +A + EAG PPG+ N+V
Sbjct: 174 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVV 233
Query: 239 PGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDA 298
G G G + H DV KV+FTGS G I + + +K VTLELGGKSP II SD
Sbjct: 234 QG-GAATGQFLCQHPDVAKVSFTGSVPTGMKI-MEMSAKGIKPVTLELGGKSPLIIFSDC 291
Query: 299 DMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQ 358
DM+ AV+ A A F QGQ CC G+R FVQ++I D+F E V + + +G+P T
Sbjct: 292 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 351
Query: 359 GPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR------GYFIQPTVFGDVQDGMTI 412
GP ++ +++LG++ K++GAK+LCGG I GY+++P V + +D MT
Sbjct: 352 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 411
Query: 413 AKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNC 472
KEEIFGPVM IL F T EV+ RAN++T+GLAA VFT+D+ +A+ + LQAGT ++N
Sbjct: 412 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 471
Query: 473 YDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKV 512
Y+V + PFGGYK SG GRE G ++ Y+++KTV V++
Sbjct: 472 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 332 bits (852), Expect = 4e-91
Identities = 182/463 (39%), Positives = 267/463 (57%), Gaps = 14/463 (3%)
Query: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117
+PSTGEV C+V K++++ AVKAAR AF W R R+LN++ADL+E+
Sbjct: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFP---SWSSRSPQERSRVLNQVADLLEQSLE 85
Query: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDG-DFFSYTRHEPV 176
A E+ D GK ++ +D+ ++ R++A + + + +D YT PV
Sbjct: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
Query: 177 GVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVN 236
GV G I PWN PL + WK+ PA+A GN V+ K +E T +TA + L+ +AG PPGVVN
Sbjct: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
Query: 237 IVPGFGPTAGAAIASHEDVDKVAFTGSTEIG-RVIQVAAGSSNLKRVTLELGGKSPNIIM 295
IV G GP G A+ SH +V ++FTGS R+ Q++A + K+++LELGGK+P II
Sbjct: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA--PHCKKLSLELGGKNPAIIF 263
Query: 296 SDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSK 355
DA++D + + F NQG+ C SR FVQ+ IY EF++R V + VG P D
Sbjct: 264 EDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL 323
Query: 356 TEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAA-------DRGYFIQPTVFGDVQD 408
G + + +K+ Y+ EGA++ CG G+ GYF+ PTV D++D
Sbjct: 324 VSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKD 383
Query: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
EEIFGPV ++ F + EEV+ RANN YGLAA V++ ++ + + +++ LQ+G V
Sbjct: 384 ESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLV 443
Query: 469 WVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511
W NC+ + PFGG K SG GRE + +TE+KT+TVK
Sbjct: 444 WTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 273 bits (698), Expect = 3e-73
Identities = 165/463 (35%), Positives = 245/463 (52%), Gaps = 68/463 (14%)
Query: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117
+PSTGEV C+V K++++ AVKAAR AF W R R+LN++ADL+E+
Sbjct: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFP---SWSSRSPQERSRVLNQVADLLEQSLE 85
Query: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDG-DFFSYTRHEPV 176
A E+ D GK ++ +D+ ++ R++A + + + +D YT PV
Sbjct: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
Query: 177 GVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVN 236
GV G I PWN PL + WK+ PA+A GN V+ K +E T +TA + L+ +AG PPGVVN
Sbjct: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
Query: 237 IVPGFGPTAGAAIASHEDVDKVAFTGSTEIG-RVIQVAAGSSNLKRVTLELGGKSPNIIM 295
IV G GP G A+ SH +V ++FTGS R+ Q++A + K+++LELGGK+P II
Sbjct: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA--PHCKKLSLELGGKNPAIIF 263
Query: 296 SDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSK 355
DA++D + + F NQ + +V+R++A
Sbjct: 264 EDANLDECIPATVRSSFANQVR----------------SYVKRALA-------------- 293
Query: 356 TEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGI-------AADRGYFIQPTVFGDVQD 408
EGA++ CG G+ GYF+ PTV D++D
Sbjct: 294 ------------------------EGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKD 329
Query: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
EEIFGPV ++ F + EEV+ RANN YGLAA V++ ++ + + +++ LQ+G V
Sbjct: 330 ESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLV 389
Query: 469 WVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511
W NC+ + PFGG K SG GRE + +TE+KT+TVK
Sbjct: 390 WTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 257 bits (656), Expect = 2e-68
Identities = 167/474 (35%), Positives = 254/474 (53%), Gaps = 12/474 (2%)
Query: 40 FINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDAS 99
F+ W A + TFP +P++G + VA+ + AV+AA AF WR + A
Sbjct: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118
Query: 100 HRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK 159
R LL + +L+ +++ LA + T ++GKP ++ L L +++ A + +G
Sbjct: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRVYGD 177
Query: 160 TIPIDG-DFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTA 218
I D + +P+GV I PWNFP M K+G ALA G VV+K AE TP +A
Sbjct: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237
Query: 219 LYVANLIKEAGFPPGVVNIVPGFGPTA---GAAIASHEDVDKVAFTGSTEIGRVIQVAAG 275
L +A L +AG P GV N++P A G AI + V K++FTGST G+++ A
Sbjct: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297
Query: 276 SSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEF 335
+S +KRV++ELGG +P I+ A++D AV A + F N GQ C ++ VQ I+D F
Sbjct: 298 NS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356
Query: 336 VER-SVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR 394
V+ + A K+ VGN F+ T QGP ++E +K+ +N +GA ++ GG
Sbjct: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416
Query: 395 GYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLD 454
F +PT+ +V M EE FGP+ ++KF T EE + AN + GLA +++D
Sbjct: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476
Query: 455 KANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTV 508
+ +++ L+ G V VN + + PFGG K SG GRE +YG+ Y E+K V
Sbjct: 477 QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 248 bits (632), Expect = 1e-65
Identities = 167/487 (34%), Positives = 254/487 (52%), Gaps = 25/487 (5%)
Query: 40 FINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDAS 99
F+ W A + TFP +P++G + VA+ + AV+AA AF WR + A
Sbjct: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118
Query: 100 HRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK 159
R LL + +L+ +++ LA + T ++GKP ++ L L +++ A + +G
Sbjct: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRVYGD 177
Query: 160 TIPIDG-DFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTA 218
I D + +P+GV I PWNFP M K+G ALA G VV+K AE TP +A
Sbjct: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237
Query: 219 LYVAN-------------LIKEAGFPPGVVNIVPGFGPTA---GAAIASHEDVDKVAFTG 262
L +A L +AG P GV N++P A G AI + V K++FTG
Sbjct: 238 LALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTG 297
Query: 263 STEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAG 322
ST G+++ A +S +KRV++ELGG +P I+ A++D AV A + F N GQ C
Sbjct: 298 STTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCS 356
Query: 323 SRTFVQEDIYDEFVER-SVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEG 381
++ VQ I+D FV+ + A K+ VGN F+ T QGP ++E +K+ +N +G
Sbjct: 357 NQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG 416
Query: 382 AKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNST 441
A ++ GG F +PT+ +V M EE FGP+ ++KF T EE + AN +
Sbjct: 417 ATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 476
Query: 442 YGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQA 501
GLA +++D + +++ L+ G V VN + + PFGG K SG GRE +YG+
Sbjct: 477 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 536
Query: 502 YTEVKTV 508
Y E+K V
Sbjct: 537 YLELKYV 543
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 206 bits (525), Expect = 3e-53
Identities = 145/485 (29%), Positives = 239/485 (49%), Gaps = 25/485 (5%)
Query: 38 QIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMD 97
++FI ++ ++ S K NP+T EVI +V + K ++D A+ + + AF W
Sbjct: 41 KLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPA---WADTS 97
Query: 98 ASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYH 157
R ++L R LI+ + +A L TL+ GK + D+ L+ + +
Sbjct: 98 VLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE-GDVFRGLQVVEHACSVTSLMM 156
Query: 158 GKTIP-IDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPL 216
G+T+P I D Y+ P+GVC I P+NFP ++ W A+ GN +MK +E+ P
Sbjct: 157 GETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPG 216
Query: 217 TALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGS 276
+ +A L++++G P G +NI+ G I H D+ ++F GS + G I GS
Sbjct: 217 ATMLLAKLLQDSGAPDGTLNIIHGQHEAVNF-ICDHPDIKAISFVGSNKAGEYI-FERGS 274
Query: 277 SNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFV 336
+ KRV +G K+ ++M DA+ + + Q A F GQ C A S T V +++
Sbjct: 275 RHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALS-TAVLVGEAKKWL 333
Query: 337 ERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGY 396
V AK+ V + GP + +++ I++G +EGA +L G +GY
Sbjct: 334 PELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGY 393
Query: 397 ----FIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKD 452
F+ PT+ +V+ MT KEEIFGPV+ +L+ +T++E + NN+ YG A+FT +
Sbjct: 394 ENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTN 453
Query: 453 LDKANYLSQALQAGTVWVN--------CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTE 504
A + + G V VN + G++S F G G+ G+Q YT+
Sbjct: 454 GATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSF-----RGDTNFYGKQGIQFYTQ 508
Query: 505 VKTVT 509
+KT+T
Sbjct: 509 LKTIT 513
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 197 bits (502), Expect = 1e-50
Identities = 153/528 (28%), Positives = 239/528 (45%), Gaps = 34/528 (6%)
Query: 11 RLGRRL-LSAAATQAVPAPNQQPEVFCNQIFINN------------EWHDAVSR------ 51
RL R L + AA T + P +P F + + IN E ++ V
Sbjct: 3 RLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGR 62
Query: 52 -KTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLAD 110
+ T P+ E I +V + D ++ VK AR A+++ W + A RG ++ ++ D
Sbjct: 63 GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKRGEIVRQIGD 119
Query: 111 LIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSY 170
+ L +L +L+ GK ++ + ++ + Y G + G +P + +
Sbjct: 120 ALREKIQVLGSLVSLEMGK-ILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHAL 178
Query: 171 TRH-EPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIK--- 226
PVG+ G I +NFP+ + W A+ GNV + K A T L ++ V +I
Sbjct: 179 IEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVL 238
Query: 227 EAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLEL 286
E PG + + G G A+A E V+ ++FTGST++G+ + + R LEL
Sbjct: 239 EDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV-QERFGRSLLEL 297
Query: 287 GGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSR 346
GG + I DAD+ V A FA GQ C R F+ E I+DE V R
Sbjct: 298 GGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQI 357
Query: 347 VVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDV 406
VGNP+D GP + LG + K+EG ++ GG + G +++PT+ +
Sbjct: 358 RVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGL 417
Query: 407 QDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKA-NYLS-QALQ 464
+IA E F P++ + KFK EEV N GL++++FTKDL + +L +
Sbjct: 418 GHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 477
Query: 465 AGTVWVNCYDVFGAQ--SPFGGYKMSGSGRELGEYGLQAYTEVKTVTV 510
G V VN GA+ FGG K +G GRE G + Y T T+
Sbjct: 478 CGIVNVN-IPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 176 bits (445), Expect = 6e-44
Identities = 144/505 (28%), Positives = 233/505 (46%), Gaps = 28/505 (5%)
Query: 4 AAARFGPRLGRRLLSAAATQAVPAPNQ------QPEVFCNQIFINNEWHDAVSRKTFPTV 57
AA R GPR R + ++ VP + + C ++N +W R + P
Sbjct: 2 AATRAGPR-AREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
Query: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117
+P TGE + + EDV AV+AAR AF+ W R + L RLA++I++ +
Sbjct: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGVVRAQHLTRLAEVIQKHQR 117
Query: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVG 177
L LE+L G+ D+ + + L Y+A A + EP+G
Sbjct: 118 LLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEE----------ALAGWEPMG 167
Query: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237
V G I+P F L W++ PALA G VV V +P L +A L E G PG++N+
Sbjct: 168 VIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APLLLAQLAGELGPFPGILNV 226
Query: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSD 297
+ G +AS + KVAF G+ E GR ++ + + + L LG +S ++
Sbjct: 227 LSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSL-AGECAELGLALGTESLLLLTDT 284
Query: 298 ADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTE 357
AD+D AVE A + ++G G R +QE ++DE + R R G D +
Sbjct: 285 ADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVD 341
Query: 358 QGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEI 417
G + + ++ + +GA++ G + ++R ++ PT+ ++ A+ E+
Sbjct: 342 MGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY-PPTLVSNLPPASPCAQVEV 399
Query: 418 FGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFG 477
PV+ F+T +E + AN + G +A+V+++ L +A L LQ GTVW+N + +
Sbjct: 400 PWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRD 459
Query: 478 AQSPFGGYKMSGSGRELGEYGLQAY 502
P GG K SG G GL Y
Sbjct: 460 PSVPTGGCKESGCSWHGGPDGLYEY 484
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/250 (30%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 39 IFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDA 98
+F+ + +R + P + S+G + VAEG +D+ AV+AA AF W
Sbjct: 530 LFVGGRFQAPGARSSRP-IRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFP---GWAGQSP 585
Query: 99 SHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHG 158
R LL LA +ER ++ LA+ L+ + + ++++ + LR + G + G
Sbjct: 586 GARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQAQG 642
Query: 159 KTIPIDGDFFSYTR-HEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLT 217
T+ + G R EP+GV + P +PLL L PALA GN VVM + PL
Sbjct: 643 HTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLL 702
Query: 218 ALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSS 277
AL V + FP G+ N+V G +A H+DV + + GS + + ++ A+ +
Sbjct: 703 ALEVCQDMATV-FPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWAS-AG 760
Query: 278 NLKRVTLELG 287
NLK V G
Sbjct: 761 NLKPVWASRG 770
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 144 bits (364), Expect = 1e-34
Identities = 125/443 (28%), Positives = 198/443 (44%), Gaps = 22/443 (4%)
Query: 76 VDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISY 135
+ +AVK ARAAF G R R + L L LI+ L D K +Y
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 136 LVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLM 191
++ VL+ + Y WA + P Y EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 192 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIAS 251
+ A+A GN VV+K +E + A +A +I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK- 178
Query: 252 HEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFAL 311
E D + +TGST +G++I AA + +L VTLELGGKSP + + D+D A + +
Sbjct: 179 -ERFDHILYTGSTGVGKIIMTAA-AKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 312 FFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKIL 371
F N GQ C A I ++ VE+ + ++ G + G + F++++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 372 GYINTGKQEGAKLLCGG-GIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTI 430
G I EG K+ GG G AA R +I PT+ DV + +EEIFGPV+ I+ +++
Sbjct: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 431 EEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKMS 488
EE + N LA +F+ + + +G V N + PFGG S
Sbjct: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
Query: 489 GSGRELGEYGLQAYTEVKTVTVK 511
G G G+ + ++ ++ V+
Sbjct: 409 GMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 144 bits (364), Expect = 1e-34
Identities = 125/443 (28%), Positives = 198/443 (44%), Gaps = 22/443 (4%)
Query: 76 VDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISY 135
+ +AVK ARAAF G R R + L L LI+ L D K +Y
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 136 LVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLM 191
++ VL+ + Y WA + P Y EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 192 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIAS 251
+ A+A GN VV+K +E + A +A +I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK- 178
Query: 252 HEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFAL 311
E D + +TGST +G++I AA + +L VTLELGGKSP + + D+D A + +
Sbjct: 179 -ERFDHILYTGSTGVGKIIMTAA-AKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 312 FFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKIL 371
F N GQ C A I ++ VE+ + ++ G + G + F++++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 372 GYINTGKQEGAKLLCGG-GIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTI 430
G I EG K+ GG G AA R +I PT+ DV + +EEIFGPV+ I+ +++
Sbjct: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 431 EEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKMS 488
EE + N LA +F+ + + +G V N + PFGG S
Sbjct: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
Query: 489 GSGRELGEYGLQAYTEVKTVTVK 511
G G G+ + ++ ++ V+
Sbjct: 409 GMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 144 bits (364), Expect = 1e-34
Identities = 125/443 (28%), Positives = 198/443 (44%), Gaps = 22/443 (4%)
Query: 76 VDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISY 135
+ +AVK ARAAF G R R + L L LI+ L D K +Y
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 136 LVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLM 191
++ VL+ + Y WA + P Y EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 192 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIAS 251
+ A+A GN VV+K +E + A +A +I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK- 178
Query: 252 HEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFAL 311
E D + +TGST +G++I AA + +L VTLELGGKSP + + D+D A + +
Sbjct: 179 -ERFDHILYTGSTGVGKIIMTAA-AKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 312 FFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKIL 371
F N GQ C A I ++ VE+ + ++ G + G + F++++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 372 GYINTGKQEGAKLLCGG-GIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTI 430
G I EG K+ GG G AA R +I PT+ DV + +EEIFGPV+ I+ +++
Sbjct: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 431 EEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKMS 488
EE + N LA +F+ + + +G V N + PFGG S
Sbjct: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
Query: 489 GSGRELGEYGLQAYTEVKTVTVK 511
G G G+ + ++ ++ V+
Sbjct: 409 GMGSYHGKKSFETFSHRRSCLVR 431
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 139 bits (349), Expect = 8e-33
Identities = 135/507 (26%), Positives = 216/507 (42%), Gaps = 83/507 (16%)
Query: 4 AAARFGPRLGRRLLSAAATQAVPAPNQ------QPEVFCNQIFINNEWHDAVSRKTFPTV 57
AA R GPR R + ++ VP + + C ++N +W R + P
Sbjct: 2 AATRAGPR-AREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
Query: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117
+P TGE + + EDV AV+AAR AF+ W R + L RLA++I++ +
Sbjct: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGVVRAQHLTRLAEVIQKHQR 117
Query: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVG 177
L LE+L G+ D+ + + L Y+A I + EP+G
Sbjct: 118 LLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA----------IQASTQEEALAGWEPMG 167
Query: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237
V G I+P F L W++ PALA G VV V +P L +A L E G PG++N+
Sbjct: 168 VIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APLLLAQLAGELGPFPGILNV 226
Query: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIG--RVIQVAAGSSNLKRVTLELGGKSPNIIM 295
+ G + +AS + KVAF G+ E G +IQ + ++R+ +G +
Sbjct: 227 LSG-PASLVPILASQPGIRKVAFCGAPEGGLRLLIQESVWDEAMRRLQERMGR-----LR 280
Query: 296 SDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSK 355
S +D AV+ +G C + V+R V A+S
Sbjct: 281 SGRGLDGAVDMG------ARGAAAC-------------DLVQRFVREAQS---------- 311
Query: 356 TEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKE 415
+GA++ G + ++R ++ PT+ ++ A+
Sbjct: 312 ------------------------QGAQVFQAGDVPSERPFY-PPTLVSNLPPASPCAQV 346
Query: 416 EIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDV 475
E+ PV+ F+T +E + AN + G +A+V+++ L +A L LQ GTVW+N + +
Sbjct: 347 EVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGL 406
Query: 476 FGAQSPFGGYKMSGSGRELGEYGLQAY 502
P GG K SG G GL Y
Sbjct: 407 RDPSVPTGGCKESGCSWHGGPDGLYEY 433
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/250 (30%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 39 IFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDA 98
+F+ + +R + P + S+G + VAEG +D+ AV+AA AF W
Sbjct: 479 LFVGGRFQAPGARSSRP-IRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFP---GWAGQSP 534
Query: 99 SHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHG 158
R LL LA +ER ++ LA+ L+ + + ++++ + LR + G + G
Sbjct: 535 GARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQAQG 591
Query: 159 KTIPIDGDFFSYTR-HEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLT 217
T+ + G R EP+GV + P +PLL L PALA GN VVM + PL
Sbjct: 592 HTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLL 651
Query: 218 ALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSS 277
AL V + FP G+ N+V G +A H+DV + + GS + + ++ A+ +
Sbjct: 652 ALEVCQDMATV-FPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWAS-AG 709
Query: 278 NLKRVTLELG 287
NLK V G
Sbjct: 710 NLKPVWASRG 719
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 137 bits (346), Expect = 2e-32
Identities = 122/454 (26%), Positives = 206/454 (45%), Gaps = 28/454 (6%)
Query: 62 GEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDR-TYLA 120
G + + DK ++KA++AA AA + W + R ++ + AD++ R +
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
Query: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK---TIPIDGDFFSYTRHEPVG 177
A + GK + + + ++ R+ A +A + G+ ++P + Y E G
Sbjct: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
Query: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237
I P+NF + PAL GNVV+ K ++ L + V +++EAG PP ++
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVI--QVAAGSS---NLKRVTLELGGKSPN 292
VP GP G + S E + + FTGS + + QVA R+ E GGK+ +
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 293 IIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPF 352
+ AD++ V + F GQ C A SR +V ++ + R + VG+P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 353 -DSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR-GYFIQPTVFGDVQDGM 410
D T +D F +I ++ + + + GG D GYF++P +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 411 TIAKEEIFGPVMQIL-----KFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQ- 464
I KEEIFGPV+ + K+K ++V + ++YGL AVF++D D ++ L+
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
Query: 465 -AGTVWVNCYDV--FGAQSPFGGYKMSGSGRELG 495
AG ++N Q PFGG + SG+ + G
Sbjct: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 137 bits (346), Expect = 2e-32
Identities = 122/454 (26%), Positives = 206/454 (45%), Gaps = 28/454 (6%)
Query: 62 GEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDR-TYLA 120
G + + DK ++KA++AA AA + W + R ++ + AD++ R +
Sbjct: 28 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 84
Query: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK---TIPIDGDFFSYTRHEPVG 177
A + GK + + + ++ R+ A +A + G+ ++P + Y E G
Sbjct: 85 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 142
Query: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237
I P+NF + PAL GNVV+ K ++ L + V +++EAG PP ++
Sbjct: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
Query: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVI--QVAAGSS---NLKRVTLELGGKSPN 292
VP GP G + S E + + FTGS + + QVA R+ E GGK+ +
Sbjct: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
Query: 293 IIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPF 352
+ AD++ V + F GQ C A SR +V ++ + R + VG+P
Sbjct: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
Query: 353 -DSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR-GYFIQPTVFGDVQDGM 410
D T +D F +I ++ + + + GG D GYF++P +
Sbjct: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
Query: 411 TIAKEEIFGPVMQIL-----KFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQ- 464
I KEEIFGPV+ + K+K ++V + ++YGL AVF++D D ++ L+
Sbjct: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 439
Query: 465 -AGTVWVNCYDV--FGAQSPFGGYKMSGSGRELG 495
AG ++N Q PFGG + SG+ + G
Sbjct: 440 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 137 bits (346), Expect = 2e-32
Identities = 122/454 (26%), Positives = 206/454 (45%), Gaps = 28/454 (6%)
Query: 62 GEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDR-TYLA 120
G + + DK ++KA++AA AA + W + R ++ + AD++ R +
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
Query: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK---TIPIDGDFFSYTRHEPVG 177
A + GK + + + ++ R+ A +A + G+ ++P + Y E G
Sbjct: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
Query: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237
I P+NF + PAL GNVV+ K ++ L + V +++EAG PP ++
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVI--QVAAGSS---NLKRVTLELGGKSPN 292
VP GP G + S E + + FTGS + + QVA R+ E GGK+ +
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 293 IIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPF 352
+ AD++ V + F GQ C A SR +V ++ + R + VG+P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 353 -DSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR-GYFIQPTVFGDVQDGM 410
D T +D F +I ++ + + + GG D GYF++P +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 411 TIAKEEIFGPVMQIL-----KFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQ- 464
I KEEIFGPV+ + K+K ++V + ++YGL AVF++D D ++ L+
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
Query: 465 -AGTVWVNCYDV--FGAQSPFGGYKMSGSGRELG 495
AG ++N Q PFGG + SG+ + G
Sbjct: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 129 bits (323), Expect = 8e-30
Identities = 91/336 (27%), Positives = 162/336 (48%), Gaps = 13/336 (3%)
Query: 174 EPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPG 233
EP G+ I PWN+PL + L ALA G+ VV+K +E + T +A ++ +
Sbjct: 22 EPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-LDQS 80
Query: 234 VVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNI 293
+V G GP + H+ +D + FTGS +G+++ AA + +L VTLELGGK+P
Sbjct: 81 CFAVVLG-GPQETGQLLEHK-LDYIFFTGSPRVGKIVMTAA-TKHLTPVTLELGGKNPCY 137
Query: 294 IMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFD 353
+ + D + + +FN GQ C A ++ + + ++ +R G+
Sbjct: 138 VDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDPQ 196
Query: 354 SKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIA 413
S G +++ QF+++ + G+ + GG + + +I PTV DVQ+ +
Sbjct: 197 SSPNLGRIINQKQFQRLRALLGCGR------VAIGGQSNESDRYIAPTVLVDVQETEPVM 250
Query: 414 KEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCY 473
+EEIFGP++ I+ ++++E + N LA F+ N + + +G+ N
Sbjct: 251 QEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGGNEG 310
Query: 474 DVFGA--QSPFGGYKMSGSGRELGEYGLQAYTEVKT 507
+ + PFGG SG GR G++ ++ +T
Sbjct: 311 FTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 129 bits (323), Expect = 8e-30
Identities = 91/336 (27%), Positives = 162/336 (48%), Gaps = 13/336 (3%)
Query: 174 EPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPG 233
EP G+ I PWN+PL + L ALA G+ VV+K +E + T +A ++ +
Sbjct: 22 EPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-LDQS 80
Query: 234 VVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNI 293
+V G GP + H+ +D + FTGS +G+++ AA + +L VTLELGGK+P
Sbjct: 81 CFAVVLG-GPQETGQLLEHK-LDYIFFTGSPRVGKIVMTAA-TKHLTPVTLELGGKNPCY 137
Query: 294 IMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFD 353
+ + D + + +FN GQ C A ++ + + ++ +R G+
Sbjct: 138 VDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDPQ 196
Query: 354 SKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIA 413
S G +++ QF+++ + G+ + GG + + +I PTV DVQ+ +
Sbjct: 197 SSPNLGRIINQKQFQRLRALLGCGR------VAIGGQSNESDRYIAPTVLVDVQETEPVM 250
Query: 414 KEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCY 473
+EEIFGP++ I+ ++++E + N LA F+ N + + +G+ N
Sbjct: 251 QEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGGNEG 310
Query: 474 DVFGA--QSPFGGYKMSGSGRELGEYGLQAYTEVKT 507
+ + PFGG SG GR G++ ++ +T
Sbjct: 311 FTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 127 bits (319), Expect = 2e-29
Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 13/347 (3%)
Query: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228
++ R EP G+ I PWN+PL + L ALA GN VV+K +E + +A ++ +
Sbjct: 98 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
Query: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288
+V G GP + H D + FTGS +G+++ AA + +L VTLELGG
Sbjct: 158 -VDQSCFAVVLG-GPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAA-AKHLTPVTLELGG 213
Query: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348
K+P + + D + + +FN GQ C A ++ + + ++ +R
Sbjct: 214 KNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFY 272
Query: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408
G+ S G +++ QF+++ + G+ + GG + + +I PTV DVQ+
Sbjct: 273 GDDPQSSPNLGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQE 326
Query: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
+ +EEIFGP++ I+ ++++E + N LA F+ + +G
Sbjct: 327 MEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGF 386
Query: 469 WVN--CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVP 513
N + A PFGG SG GR G++ ++ + ++ P
Sbjct: 387 CGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 127 bits (319), Expect = 2e-29
Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 13/347 (3%)
Query: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228
++ R EP G+ I PWN+PL + L ALA GN VV+K +E + +A ++ +
Sbjct: 61 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 120
Query: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288
+V G GP + H D + FTGS +G+++ AA + +L VTLELGG
Sbjct: 121 -VDQSCFAVVLG-GPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAA-AKHLTPVTLELGG 176
Query: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348
K+P + + D + + +FN GQ C A ++ + + ++ +R
Sbjct: 177 KNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFY 235
Query: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408
G+ S G +++ QF+++ + G+ + GG + + +I PTV DVQ+
Sbjct: 236 GDDPQSSPNLGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQE 289
Query: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
+ +EEIFGP++ I+ ++++E + N LA F+ + +G
Sbjct: 290 MEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGF 349
Query: 469 WVN--CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVP 513
N + A PFGG SG GR G++ ++ + ++ P
Sbjct: 350 CGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 127 bits (319), Expect = 2e-29
Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 13/347 (3%)
Query: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228
++ R EP G+ I PWN+PL + L ALA GN VV+K +E + +A ++ +
Sbjct: 98 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
Query: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288
+V G GP + H D + FTGS +G+++ AA + +L VTLELGG
Sbjct: 158 -VDQSCFAVVLG-GPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAA-AKHLTPVTLELGG 213
Query: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348
K+P + + D + + +FN GQ C A ++ + + ++ +R
Sbjct: 214 KNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFY 272
Query: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408
G+ S G +++ QF+++ + G+ + GG + + +I PTV DVQ+
Sbjct: 273 GDDPQSSPNLGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQE 326
Query: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
+ +EEIFGP++ I+ ++++E + N LA F+ + +G
Sbjct: 327 MEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGF 386
Query: 469 WVN--CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVP 513
N + A PFGG SG GR G++ ++ + ++ P
Sbjct: 387 CGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 122 bits (307), Expect = 6e-28
Identities = 98/347 (28%), Positives = 158/347 (45%), Gaps = 17/347 (4%)
Query: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228
+Y + +P+GV I WN+P ++ L A+A GN V++K +E + TA +A L+ +
Sbjct: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
Query: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288
+ I G T + D + +TG+T +G+++ AA + +L VTLELGG
Sbjct: 155 LDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAA-AKHLTPVTLELGG 210
Query: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348
KSP I D D+D + + + N GQ C A + + ++ V + +
Sbjct: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFY 269
Query: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408
G + ++ FK+IL + EG K+ GG Y I PTV DV
Sbjct: 270 GENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETDEATRY-IAPTVLTDVDP 323
Query: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
+ +EEIFGP++ I+ K ++E + N LA VF+ + + +G V
Sbjct: 324 KTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV 383
Query: 469 WVNCYDV---FGAQS-PFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511
N DV F S PFGG SG G G++ ++ + +K
Sbjct: 384 TGN--DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,110,785
Number of Sequences: 37866
Number of extensions: 852819
Number of successful extensions: 1694
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1546
Number of HSP's gapped (non-prelim): 37
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.