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Search of human proteins with 25777730
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
(517 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 1048 0.0
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 770 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 706 0.0
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 671 0.0
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 660 0.0
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 621 e-178
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 621 e-178
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 465 e-131
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 459 e-129
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 358 9e-99
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 326 3e-89
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 259 3e-69
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 259 5e-69
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 249 3e-66
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 221 1e-57
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 215 9e-56
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 176 5e-44
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 147 2e-35
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 147 2e-35
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 147 2e-35
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 139 5e-33
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 139 5e-33
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 139 5e-33
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 135 1e-31
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 127 3e-29
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 127 3e-29
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 124 3e-28
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 124 3e-28
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 120 2e-27
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 119 5e-27
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 1048 bits (2711), Expect = 0.0
Identities = 517/517 (100%), Positives = 517/517 (100%)
Query: 1 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT 60
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
Sbjct: 1 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT 60
Query: 61 TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLA 120
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLA
Sbjct: 61 TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLA 120
Query: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG 180
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
Sbjct: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG 180
Query: 181 QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG 240
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
Sbjct: 181 QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG 240
Query: 241 YGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM 300
YGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
Sbjct: 241 YGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM 300
Query: 301 EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP 360
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
Sbjct: 301 EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP 360
Query: 361 QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP 420
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
Sbjct: 361 QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP 420
Query: 421 VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT 480
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
Sbjct: 421 VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT 480
Query: 481 PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS 517
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS
Sbjct: 481 PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS 517
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 770 bits (1989), Expect = 0.0
Identities = 376/517 (72%), Positives = 437/517 (84%)
Query: 1 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT 60
MLR A L R ++ A+P+P P++ NQ+FINNEW DAVS+KTFPTVNP+
Sbjct: 1 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS 60
Query: 61 TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLA 120
TGEVI VAEGD+ DVD+AVKAAR AF+LGSPWRRMDAS RGRLLNRLADL+ERDR YLA
Sbjct: 61 TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA 120
Query: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG 180
+LETLDNGKP+ SY +DLD V+K RY+AGWADK+HGKTIP+DG F +TRHEPVGVCG
Sbjct: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG 180
Query: 181 QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG 240
QIIPWNFPL+MQ WKL PALATGN VVMKVAEQTPL+ALY+A+LIKEAGFPPGVVNI+ G
Sbjct: 181 QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG 240
Query: 241 YGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM 300
+GPTAGAAIA H DVDKVAFTGSTE+G +IQ AAG SNLKRVTLELGGKSP+I+++DADM
Sbjct: 241 FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM 300
Query: 301 EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP 360
+ AVEQ H ALFFN GQCCCAGSRTFV+E IY+EF+ER+V +AK R VGNPF+ T+QGP
Sbjct: 301 DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP 360
Query: 361 QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP 420
QVD+ QF+++LGYI G++EGAKLLCGG +RG+FI+PTVFG VQD M IAKEEIFGP
Sbjct: 361 QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP 420
Query: 421 VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT 480
V + KFK IEEVV RANN+ YGLAAAVFT+DLDKA Y +QALQAGTVWVN Y++ +
Sbjct: 421 VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS 480
Query: 481 PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS 517
PFGG+K SG+GRELGE GL+AYTEVKTVT+KVPQKNS
Sbjct: 481 PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 517
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 706 bits (1823), Expect = 0.0
Identities = 333/501 (66%), Positives = 413/501 (82%)
Query: 17 ARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADV 76
A +S LPSP N +I Y ++FINNEWQ++ S + FP NP TGE + V E D+AD+
Sbjct: 18 ALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADI 77
Query: 77 DRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYA 136
D+AV+AAR AF LGS WRRMDASERGRLL++LADLVERDR LA++E+L+ GKPF +++
Sbjct: 78 DKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFY 137
Query: 137 LDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKL 196
+DL VIK +RY+AGWADK HG TIP+DG +F FTRHEP+GVCGQIIPWNFPL+M WK+
Sbjct: 138 VDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKI 197
Query: 197 APALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVD 256
APAL GNTVV+K AEQTPLSALY+ +LIKEAGFPPGV+NI+ GYGPTAGAAIA H+ +D
Sbjct: 198 APALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGID 257
Query: 257 KVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMG 316
K+AFTGSTEVG LIQ+AAG SNLKRVTLELGGKSP+I+ ADAD+++AVEQ H+ +FFN G
Sbjct: 258 KIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQG 317
Query: 317 QCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQL 376
QCC AGSR FVEESIY EF+ R+VE+AK+R VG+PF+ T+QGPQ+DK+Q+ ++L IQ
Sbjct: 318 QCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQS 377
Query: 377 GQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVER 436
G EGAKL CGG+ G +GFFI+PTVF V DDMRIAKEEIFGPVQ + +FK ++EV+ER
Sbjct: 378 GVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIER 437
Query: 437 ANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGE 496
ANN+ +GL AAVFT D++KA+ + A+QAGTVW+N YN + +PFGGFK SGNGRE+GE
Sbjct: 438 ANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGE 497
Query: 497 DGLKAYTEVKTVTIKVPQKNS 517
GL+ Y+EVKTVT+K+PQKNS
Sbjct: 498 FGLREYSEVKTVTVKIPQKNS 518
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 671 bits (1732), Expect = 0.0
Identities = 324/500 (64%), Positives = 401/500 (80%), Gaps = 2/500 (0%)
Query: 20 SSAAALPSPILNPD--IPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVD 77
SS+ P+L D I Y ++FINNEW D+VS K FP NP T E + V EGD+ DVD
Sbjct: 2 SSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVD 61
Query: 78 RAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYAL 137
+AVKAAR+AF++GSPWR MDASERGRLL +LADL+ERDR+ LA++E+++ GK + +Y
Sbjct: 62 KAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLN 121
Query: 138 DLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLA 197
DL IK RY AGWADK G+TIP+DG F +TRHEP+GVCGQIIPWNFPLVM WK+
Sbjct: 122 DLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIG 181
Query: 198 PALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDK 257
PAL+ GNTVV+K AEQTPL+AL++ASLIKEAGFPPGVVNI+ GYGPTAGAAI+ H+D+DK
Sbjct: 182 PALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 241
Query: 258 VAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQ 317
VAFTGSTEVG LI++AAG SNLKRVTLELGGKSP IVLADAD+++AVE H +F++ GQ
Sbjct: 242 VAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQ 301
Query: 318 CCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLG 377
CC A SR FVEESIY+EF+ R+VE+AK+ +GNP QGPQ+DKEQ++++L I+ G
Sbjct: 302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESG 361
Query: 378 QKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERA 437
+KEGAKL CGG +G +G+F++PTVF V D+MRIAKEEIFGPVQ + KFK +++V++RA
Sbjct: 362 KKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRA 421
Query: 438 NNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGED 497
NNT YGL+A VFT+D+DKA+ + ALQAGTVWVN Y +V+ PFGGFK SGNGRELGE
Sbjct: 422 NNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEY 481
Query: 498 GLKAYTEVKTVTIKVPQKNS 517
G YTEVKTVT+K+ QKNS
Sbjct: 482 GFHEYTEVKTVTVKISQKNS 501
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 660 bits (1704), Expect = 0.0
Identities = 317/493 (64%), Positives = 391/493 (79%)
Query: 24 ALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAA 83
ALP PI N ++ + ++FINNEW ++ S K F T NP+T E I V EGD+ DVD+AV+AA
Sbjct: 19 ALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAA 78
Query: 84 REAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVI 143
+ AF+ GSPWRR+DA RGRLL++LADLVERDR LA+LET+D GKPF ++ +DL+ I
Sbjct: 79 QVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCI 138
Query: 144 KVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATG 203
+ RYFAGWADK GKTIP D CFTRHEP+GVCG I PWNFPL+M WKLAPAL G
Sbjct: 139 RTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCG 198
Query: 204 NTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGS 263
NT+V+K AEQTPL+ALYL SLIKEAGFPPGVVNI+ G+GPT GAAI+ H ++K+AFTGS
Sbjct: 199 NTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGS 258
Query: 264 TEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGS 323
TEVG L+++AA SNLKRVTLELGGK+P IV ADAD++ AVE H+ +FFN GQCC A S
Sbjct: 259 TEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAAS 318
Query: 324 RTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAK 383
R FVEE +Y+EF+ R+VE AK+R VG+PF++ T+QGPQ+D++QF+++L I+ G+KEGAK
Sbjct: 319 RVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAK 378
Query: 384 LLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYG 443
L CGG ++G FIKPTVF V D+MRIAKEEIFGPVQP+ KFK IEEV++RAN+T YG
Sbjct: 379 LECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYG 438
Query: 444 LAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYT 503
L AAVFT++LDKA+ AL++GTVW+N YN + PFGGFK SGNGRELGE L YT
Sbjct: 439 LTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYT 498
Query: 504 EVKTVTIKVPQKN 516
EVKTVTIK+ KN
Sbjct: 499 EVKTVTIKLGDKN 511
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 621 bits (1601), Expect = e-178
Identities = 290/422 (68%), Positives = 358/422 (84%)
Query: 96 MDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADK 155
MDASERGRLL++LADLVERDR LA++E+L+ GKPF +++ +DL VIK +RY+AGWADK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 156 WHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTP 215
HG TIP+DG +F FTRHEP+GVCGQIIPWNFPL+M WK+APAL GNTVV+K AEQTP
Sbjct: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
Query: 216 LSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAG 275
LSALY+ +LIKEAGFPPGV+NI+ GYGPTAGAAIA H+ +DK+AFTGSTEVG LIQ+AAG
Sbjct: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
Query: 276 DSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEF 335
SNLKRVTLELGGKSP+I+ ADAD+++AVEQ H+ +FFN GQCC AGSR FVEESIY EF
Sbjct: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
Query: 336 LERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERG 395
+ R+VE+AK+R VG+PF+ T+QGPQ+DK+Q+ ++L IQ G EGAKL CGG+ G +G
Sbjct: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
Query: 396 FFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDK 455
FFI+PTVF V DDMRIAKEEIFGPVQ + +FK ++EV+ERANN+ +GL AAVFT D++K
Sbjct: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
Query: 456 AMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQK 515
A+ + A+QAGTVW+N YN + +PFGGFK SGNGRE+GE GL+ Y+EVKTVT+K+PQK
Sbjct: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
Query: 516 NS 517
NS
Sbjct: 421 NS 422
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 621 bits (1601), Expect = e-178
Identities = 303/501 (60%), Positives = 378/501 (75%), Gaps = 38/501 (7%)
Query: 17 ARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADV 76
A +S LPSP N +I Y ++FINNEWQ++ S + FP NP TGE + V E D+AD+
Sbjct: 18 ALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADI 77
Query: 77 DRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYA 136
D+AV+AAR AF LGS WRRMDASERGRLL++LADLVERDR LA++E+L+ GKPF +++
Sbjct: 78 DKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFY 137
Query: 137 LDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKL 196
+DL VIK +RY+AGWADK HG TIP+DG +F FTRHEP+GVCGQIIPWNFPL+M WK+
Sbjct: 138 VDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKI 197
Query: 197 APALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVD 256
APAL GNTVV+K AEQTPLSALY+ +LIKE
Sbjct: 198 APALCCGNTVVIKPAEQTPLSALYMGALIKE----------------------------- 228
Query: 257 KVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMG 316
VG LIQ+AAG SNLKRVTLELGGKSP+I+ ADAD+++AVEQ H+ +FFN G
Sbjct: 229 ---------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQG 279
Query: 317 QCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQL 376
QCC AGSR FVEESIY EF+ R+VE+AK+R VG+PF+ T+QGPQ+DK+Q+ ++L IQ
Sbjct: 280 QCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQS 339
Query: 377 GQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVER 436
G EGAKL CGG+ G +GFFI+PTVF V DDMRIAKEEIFGPVQ + +FK ++EV+ER
Sbjct: 340 GVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIER 399
Query: 437 ANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGE 496
ANN+ +GL AAVFT D++KA+ + A+QAGTVW+N YN + +PFGGFK SGNGRE+GE
Sbjct: 400 ANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGE 459
Query: 497 DGLKAYTEVKTVTIKVPQKNS 517
GL+ Y+EVKTVT+K+PQKNS
Sbjct: 460 FGLREYSEVKTVTVKIPQKNS 480
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 465 bits (1197), Expect = e-131
Identities = 238/484 (49%), Positives = 329/484 (67%), Gaps = 8/484 (1%)
Query: 34 IPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPW 93
+PY Q FIN ++ DA KT+ T+NPT G I V+ ADVD+AV AA++AF G W
Sbjct: 441 MPY-QCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-W 498
Query: 94 RRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWA 153
RM+A ERGRL+ RLADL+E ++ LA++E LD+G + + + ++ +RYFAGW
Sbjct: 499 GRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWC 558
Query: 154 DKWHGKTIPMD----GQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMK 209
DK G TIP++ ++ FT+ EP+GVC IIPWN+PL+M WK A LA GNT+V+K
Sbjct: 559 DKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLK 618
Query: 210 VAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHL 269
A+ TPL+AL A L +AGFP GV+NII G G AG +++H D+ K+ FTGST +G
Sbjct: 619 PAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQ 678
Query: 270 IQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEE 329
I K+ SNLK+V+LELGGKSP I+ D +++ AV A+FFN G+ C A R FVEE
Sbjct: 679 IMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEE 738
Query: 330 SIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGE 389
SI++EF+ R VE+ K+ K+G+P + T GPQ K E++L Y + G KEGA L+ GG
Sbjct: 739 SIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGR 798
Query: 390 RFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKK--IEEVVERANNTRYGLAAA 447
+ GFF++PTVF V+D M +AKEE FGP+ + KF+ I+ V++RAN+T YGLA+
Sbjct: 799 QVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASG 858
Query: 448 VFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKT 507
VFTRD++KAMY ++ L+AGTV++NTYN PFGG K+SG G++LGE+ L Y + KT
Sbjct: 859 VFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKT 918
Query: 508 VTIK 511
VT++
Sbjct: 919 VTLE 922
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 459 bits (1182), Expect = e-129
Identities = 240/481 (49%), Positives = 317/481 (65%), Gaps = 7/481 (1%)
Query: 37 NQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRM 96
+QLFI E+ DA KT T+NPT G VI V+ DVD+AV AA++AF G W ++
Sbjct: 422 HQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKI 480
Query: 97 DASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKW 156
A +RGRL+ RLADL+E+ + LA++E LD G + + + I+ +RYFAGW DK
Sbjct: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
Query: 157 HGKTIPMD----GQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAE 212
G TIP++ ++ TR EPVGVCG IIPWN+PL+M WK A LA GNTVV+K A+
Sbjct: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
Query: 213 QTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQK 272
TPL+AL A L +AG P GVVN++ G G G ++ H DV K+ FTGSTEVG I K
Sbjct: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
Query: 273 AAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIY 332
+ SN+K+V+LELGGKSP I+ AD D+ AV+ ++FFN G+ C A R FVE+SI+
Sbjct: 661 SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH 720
Query: 333 NEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFG 392
+EF+ R VE+ ++ KVGNP + DT GPQ +++ Y Q G KEGA L+CGG +
Sbjct: 721 DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP 780
Query: 393 ERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFK--KIEEVVERANNTRYGLAAAVFT 450
GFF +PTVF V+D M IAKEE FGPV + +F ++ V+ RAN T +GLA+ VFT
Sbjct: 781 RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT 840
Query: 451 RDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTI 510
RD++KA+Y + LQAGTV+VNTYN PFGGFK+SG G++LGE L Y VKTVT
Sbjct: 841 RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF 900
Query: 511 K 511
+
Sbjct: 901 E 901
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 358 bits (918), Expect = 9e-99
Identities = 192/473 (40%), Positives = 284/473 (60%), Gaps = 12/473 (2%)
Query: 46 QDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLL 105
+ A + T P TG VI +V+ AV+ A+ AF++ W + ER R+L
Sbjct: 45 EPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRIL 101
Query: 106 NRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDG 165
A ++ +A++E ++NGK E+ LD+D + Y+AG A G+ I + G
Sbjct: 102 LEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQLPG 160
Query: 166 QHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLI 225
F +TR EP+GVC I WN+P + WK APALA GN +V K + TP+SAL LA +
Sbjct: 161 GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIY 220
Query: 226 KEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLE 285
EAG PPG+ N++ G G G + QH DV KV+FTGS G I + + +K VTLE
Sbjct: 221 SEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA-KGIKPVTLE 278
Query: 286 LGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQ 345
LGGKSP I+ +D DM +AV+ A F GQ CC G+R FV++ I ++F E V++ ++
Sbjct: 279 LGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQR 338
Query: 346 RKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGER------GFFIK 399
K+G+P DT+ GP +++ ERVLG++++ +++GAK+LCGG+ + G++++
Sbjct: 339 IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMR 398
Query: 400 PTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYF 459
P V +DDM KEEIFGPV + F EV+ERAN+T +GLAA VFTRD+ +A
Sbjct: 399 PCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRV 458
Query: 460 TQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKV 512
LQAGT ++N YN+ PFGG+K+SG GRE G ++ Y+++KTV +++
Sbjct: 459 VAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 326 bits (836), Expect = 3e-89
Identities = 179/462 (38%), Positives = 266/462 (57%), Gaps = 12/462 (2%)
Query: 58 NPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRV 117
+P+TGEV V + +++ AVKAAREAF W ER R+LN++ADL+E+
Sbjct: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAF---PSWSSRSPQERSRVLNQVADLLEQSLE 85
Query: 118 YLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFC-FTRHEPV 176
A E+ D GK + +D+ ++ +R+FA + + MD +T PV
Sbjct: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
Query: 177 GVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN 236
GV G I PWN PL + WK+APA+A GNTV+ K +E T ++A L L+ +AG PPGVVN
Sbjct: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
Query: 237 IITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLA 296
I+ G GP G A+ H +V ++FTGS I + + + K+++LELGGK+P+I+
Sbjct: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAP-HCKKLSLELGGKNPAIIFE 264
Query: 297 DADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDT 356
DA+++ + + F N G+ C SR FV++SIY+EFL+R VE ++ KVG P +
Sbjct: 265 DANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLV 324
Query: 357 QQGPQVDKEQFERVLGYIQLGQKEGAKLLCGG-------ERFGERGFFIKPTVFGGVQDD 409
G + K E+V Y++ EGA++ CG + G+F+ PTV ++D+
Sbjct: 325 SIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDE 384
Query: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
EEIFGPV + F EEV+ERANN +YGLAA V++ ++ + + LQ+G VW
Sbjct: 385 SCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVW 444
Query: 470 VNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 511
N + I + PFGG K SG GRE +D +TE+KT+T+K
Sbjct: 445 TNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 259 bits (663), Expect = 3e-69
Identities = 157/462 (33%), Positives = 237/462 (51%), Gaps = 66/462 (14%)
Query: 58 NPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRV 117
+P+TGEV V + +++ AVKAAREAF W ER R+LN++ADL+E+
Sbjct: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAF---PSWSSRSPQERSRVLNQVADLLEQSLE 85
Query: 118 YLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFC-FTRHEPV 176
A E+ D GK + +D+ ++ +R+FA + + MD +T PV
Sbjct: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
Query: 177 GVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN 236
GV G I PWN PL + WK+APA+A GNTV+ K +E T ++A L L+ +AG PPGVVN
Sbjct: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
Query: 237 IITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLA 296
I+ G GP G A+ H +V ++FTGS I + + + K+++LELGGK+P+I+
Sbjct: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAIIFE 264
Query: 297 DADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDT 356
DA+++ + + F N R++V+ ++
Sbjct: 265 DANLDECIPATVRSSFANQ-------VRSYVKRAL------------------------- 292
Query: 357 QQGPQVDKEQFERVLGYIQLGQKEGAKLLCGG-------ERFGERGFFIKPTVFGGVQDD 409
EGA++ CG + G+F+ PTV ++D+
Sbjct: 293 ----------------------AEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDE 330
Query: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
EEIFGPV + F EEV+ERANN +YGLAA V++ ++ + + LQ+G VW
Sbjct: 331 SCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVW 390
Query: 470 VNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 511
N + I + PFGG K SG GRE +D +TE+KT+T+K
Sbjct: 391 TNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 259 bits (661), Expect = 5e-69
Identities = 170/474 (35%), Positives = 251/474 (52%), Gaps = 12/474 (2%)
Query: 40 FINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDAS 99
F+ W A + TFP +P +G +G VA+ + AV+AA EAF WR + A
Sbjct: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118
Query: 100 ERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK 159
ER LL + +L+ +++ LA + T ++GKP +E++ L + +F+ A + +G
Sbjct: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFL-EWFSEEARRVYGD 177
Query: 160 TIPMDGQ-HFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSA 218
I + +P+GV I PWNFP M K+ ALA G TVV+K AE TP SA
Sbjct: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237
Query: 219 LYLASLIKEAGFPPGVVNIITGYGPTA---GAAIAQHVDVDKVAFTGSTEVGHLIQKAAG 275
L LA L +AG P GV N+I A G AI V K++FTGST G ++ A
Sbjct: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297
Query: 276 DSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEF 335
+S +KRV++ELGG +P IV A+++ AV + F N GQ C ++ V+ I++ F
Sbjct: 298 NS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356
Query: 336 LERTVEKAKQR-KVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGER 394
++ E K+ +VGN FE T QGP ++++ E+V + +GA ++ GG+R
Sbjct: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416
Query: 395 GFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLD 454
F +PT+ V DM EE FGP+ P+ KF EE + AN GLA +++D
Sbjct: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476
Query: 455 KAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTV 508
+ + L+ G V VN I + PFGG K+SG GRE + G+ Y E+K V
Sbjct: 477 QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 249 bits (637), Expect = 3e-66
Identities = 170/487 (34%), Positives = 251/487 (51%), Gaps = 25/487 (5%)
Query: 40 FINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDAS 99
F+ W A + TFP +P +G +G VA+ + AV+AA EAF WR + A
Sbjct: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118
Query: 100 ERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK 159
ER LL + +L+ +++ LA + T ++GKP +E++ L + +F+ A + +G
Sbjct: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFL-EWFSEEARRVYGD 177
Query: 160 TIPMDGQ-HFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSA 218
I + +P+GV I PWNFP M K+ ALA G TVV+K AE TP SA
Sbjct: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237
Query: 219 LYLAS-------------LIKEAGFPPGVVNIITGYGPTA---GAAIAQHVDVDKVAFTG 262
L LA L +AG P GV N+I A G AI V K++FTG
Sbjct: 238 LALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTG 297
Query: 263 STEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAG 322
ST G ++ A +S +KRV++ELGG +P IV A+++ AV + F N GQ C
Sbjct: 298 STTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCS 356
Query: 323 SRTFVEESIYNEFLERTVEKAKQR-KVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEG 381
++ V+ I++ F++ E K+ +VGN FE T QGP ++++ E+V + +G
Sbjct: 357 NQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG 416
Query: 382 AKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTR 441
A ++ GG+R F +PT+ V DM EE FGP+ P+ KF EE + AN
Sbjct: 417 ATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 476
Query: 442 YGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKA 501
GLA +++D + + L+ G V VN I + PFGG K+SG GRE + G+
Sbjct: 477 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 536
Query: 502 YTEVKTV 508
Y E+K V
Sbjct: 537 YLELKYV 543
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 221 bits (563), Expect = 1e-57
Identities = 155/517 (29%), Positives = 252/517 (48%), Gaps = 15/517 (2%)
Query: 1 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT 60
+L A R LQ + SS + + +P +LFI ++ ++ S K NP
Sbjct: 4 LLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPA 63
Query: 61 TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLA 120
T EVIG V + +A++D A+ + + AF W R ++L R L++ + +A
Sbjct: 64 TNEVIGRVPQATKAEMDAAIASCKRAF---PAWADTSVLSRQQVLLRYQQLIKENLKEIA 120
Query: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHF-CFTRHEPVGVC 179
L TL+ GK ++ D+ ++V + G+T+P + ++ P+GVC
Sbjct: 121 KLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVC 179
Query: 180 GQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIIT 239
I P+NFP ++ W A+ GNT +MK +E+ P + + LA L++++G P G +NII
Sbjct: 180 AGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIH 239
Query: 240 GYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADAD 299
G I H D+ ++F GS + G I + G + KRV +G K+ +V+ DA+
Sbjct: 240 GQHEAVN-FICDHPDIKAISFVGSNKAGEYIFE-RGSRHGKRVQANMGAKNHGVVMPDAN 297
Query: 300 MEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQG 359
E+ + Q A F GQ C A S T V ++L VE AK +V + G
Sbjct: 298 KENTLNQLVGAAFGAAGQRCMALS-TAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLG 356
Query: 360 PQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGF----FIKPTVFGGVQDDMRIAKE 415
P + + ERV I G KEGA +L G + +G+ F+ PT+ V+ +M KE
Sbjct: 357 PLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKE 416
Query: 416 EIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNT-YN 474
EIFGPV + + + ++E ++ NN YG A+FT + A + + G V VN
Sbjct: 417 EIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIP 476
Query: 475 IVTCHTPFGGFKES--GNGRELGEDGLKAYTEVKTVT 509
+ F G + S G+ G+ G++ YT++KT+T
Sbjct: 477 VPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 215 bits (547), Expect = 9e-56
Identities = 149/467 (31%), Positives = 227/467 (48%), Gaps = 22/467 (4%)
Query: 56 TVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERD 115
T P E I V + AD + VK AREA+++ W + A +RG ++ ++ D +
Sbjct: 68 TYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKRGEIVRQIGDALREK 124
Query: 116 RVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQ-HFCFTRHE 174
L SL +L+ GK E ++ E + + Y G + G +P + H +
Sbjct: 125 IQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWN 183
Query: 175 PVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIK---EAGFP 231
PVG+ G I +NFP+ + GW A A+ GN + K A T L ++ + +I E
Sbjct: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243
Query: 232 PGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGH----LIQKAAGDSNLKRVTLELG 287
PG + +T G G A+A+ V+ ++FTGST+VG ++Q+ G R LELG
Sbjct: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFG-----RSLLELG 298
Query: 288 GKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRK 347
G + I DAD+ V A GQ C R F+ ESI++E + R + Q +
Sbjct: 299 GNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIR 358
Query: 348 VGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQ 407
VGNP++ + GP K+ LG ++ +KEG ++ GG+ G +++PT+ G+
Sbjct: 359 VGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLG 418
Query: 408 DDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGT 467
D IA E F P+ +FKFK EEV N + GL++++FT+DL + + +
Sbjct: 419 HDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDC 478
Query: 468 VWVNTYNIVTCHT----PFGGFKESGNGRELGEDGLKAYTEVKTVTI 510
VN NI T FGG K +G GRE G D K Y T TI
Sbjct: 479 GIVNV-NIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 176 bits (446), Expect = 5e-44
Identities = 133/463 (28%), Positives = 221/463 (47%), Gaps = 21/463 (4%)
Query: 40 FINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDAS 99
++N +W + + P +P TGE + + DV AV+AAR AF+ W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
Query: 100 ERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK 159
R + L RLA+++++ + L +LE+L G+ +E D+ ++ Y A
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
Query: 160 TIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSAL 219
I Q EP+GV G I+P F + W++ PALA G TVV V +P + L
Sbjct: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APL 208
Query: 220 YLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNL 279
LA L E G PG++N+++G +A + KVAF G+ E G ++++
Sbjct: 209 LLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-GEC 266
Query: 280 KRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERT 339
+ L LG +S ++ AD++ AVE +A + + G G R ++ES+++E + R
Sbjct: 267 AELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRRL 323
Query: 340 VEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIK 399
E+ + + G + G + + V +++ Q +GA++ G+ ER F+
Sbjct: 324 QERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY-P 381
Query: 400 PTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYF 459
PT+ + A+ E+ PV F+ +E + AN T G +A+V++ L +A+
Sbjct: 382 PTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALEL 441
Query: 460 TQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAY 502
LQ GTVW+N + + P GG KESG G DGL Y
Sbjct: 442 GYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
Score = 88.2 bits (217), Expect = 2e-17
Identities = 92/293 (31%), Positives = 134/293 (45%), Gaps = 25/293 (8%)
Query: 7 PRLLSLQGRTARYSS-AAALPSPI-LNPDI------PYNQLFINNEWQDAVSKKTFPTVN 58
P LS + Y + A+PS + P+I PY LF+ +Q ++ + P +
Sbjct: 491 PARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYG-LFVGGRFQAPGARSSRP-IR 548
Query: 59 PTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVY 118
++G + G+VAEG D+ AV+AA +AF W R LL LA +ER +
Sbjct: 549 DSSGNLHGYVAEGGAKDIRGAVEAAHQAF---PGWAGQSPGARAALLWALAAALERRKST 605
Query: 119 LAS-LETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWH--GKTIPMDGQHFCFTR-HE 174
LAS LE G + + A EV R W + G T+ + G R E
Sbjct: 606 LASRLER--QGAELKAAEA----EVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLRE 659
Query: 175 PVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGV 234
P+GV + P +PL+ LAPALA GNTVVM + PL AL + + FP G+
Sbjct: 660 PLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGL 718
Query: 235 VNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELG 287
N++TG +A H DV + + GS + ++ A+ NLK V G
Sbjct: 719 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASA-GNLKPVWASRG 770
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 147 bits (371), Expect = 2e-35
Identities = 123/440 (27%), Positives = 199/440 (45%), Gaps = 16/440 (3%)
Query: 76 VDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNG-KPFQES 134
+ AVK AR AF G ++ L RL E++ V + + N + E
Sbjct: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
Query: 135 YALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGW 194
L+E+ + + WA + P Q + EP+GV I WN+P +
Sbjct: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123
Query: 195 KLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVD 254
+ A+A GN+VV+K +E + A LA++I + + +I G P + + D
Sbjct: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFD 182
Query: 255 VDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFN 314
+ +TGST VG +I AA +L VTLELGGKSP V + D++ A + F N
Sbjct: 183 --HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 315 MGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYI 374
GQ C A + SI N+ +E+ ++K+ + G + G + F+RV+G I
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 375 QLGQKEGAKLLCGGERFGERGF-FIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEV 433
EG K+ GG G+ +I PT+ V + +EEIFGPV P+ + +EE
Sbjct: 299 -----EGQKVAYGGT--GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 434 VERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNI-VTCHT-PFGGFKESGNG 491
++ N LA +F+ + +G V N + +T H+ PFGG SG G
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
Query: 492 RELGEDGLKAYTEVKTVTIK 511
G+ + ++ ++ ++
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 147 bits (371), Expect = 2e-35
Identities = 123/440 (27%), Positives = 199/440 (45%), Gaps = 16/440 (3%)
Query: 76 VDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNG-KPFQES 134
+ AVK AR AF G ++ L RL E++ V + + N + E
Sbjct: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
Query: 135 YALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGW 194
L+E+ + + WA + P Q + EP+GV I WN+P +
Sbjct: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123
Query: 195 KLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVD 254
+ A+A GN+VV+K +E + A LA++I + + +I G P + + D
Sbjct: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFD 182
Query: 255 VDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFN 314
+ +TGST VG +I AA +L VTLELGGKSP V + D++ A + F N
Sbjct: 183 --HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 315 MGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYI 374
GQ C A + SI N+ +E+ ++K+ + G + G + F+RV+G I
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 375 QLGQKEGAKLLCGGERFGERGF-FIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEV 433
EG K+ GG G+ +I PT+ V + +EEIFGPV P+ + +EE
Sbjct: 299 -----EGQKVAYGGT--GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 434 VERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNI-VTCHT-PFGGFKESGNG 491
++ N LA +F+ + +G V N + +T H+ PFGG SG G
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
Query: 492 RELGEDGLKAYTEVKTVTIK 511
G+ + ++ ++ ++
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 147 bits (371), Expect = 2e-35
Identities = 123/440 (27%), Positives = 199/440 (45%), Gaps = 16/440 (3%)
Query: 76 VDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNG-KPFQES 134
+ AVK AR AF G ++ L RL E++ V + + N + E
Sbjct: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
Query: 135 YALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGW 194
L+E+ + + WA + P Q + EP+GV I WN+P +
Sbjct: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123
Query: 195 KLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVD 254
+ A+A GN+VV+K +E + A LA++I + + +I G P + + D
Sbjct: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFD 182
Query: 255 VDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFN 314
+ +TGST VG +I AA +L VTLELGGKSP V + D++ A + F N
Sbjct: 183 --HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 315 MGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYI 374
GQ C A + SI N+ +E+ ++K+ + G + G + F+RV+G I
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 375 QLGQKEGAKLLCGGERFGERGF-FIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEV 433
EG K+ GG G+ +I PT+ V + +EEIFGPV P+ + +EE
Sbjct: 299 -----EGQKVAYGGT--GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 434 VERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNI-VTCHT-PFGGFKESGNG 491
++ N LA +F+ + +G V N + +T H+ PFGG SG G
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
Query: 492 RELGEDGLKAYTEVKTVTIK 511
G+ + ++ ++ ++
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 139 bits (351), Expect = 5e-33
Identities = 119/454 (26%), Positives = 213/454 (46%), Gaps = 28/454 (6%)
Query: 62 GEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDR-VYLA 120
G + D++ +++A++AA A + W ++R ++ + AD++ R +
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
Query: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK---TIPMDGQHFCFTRHEPVG 177
+ + GK ++ E+I +R+ A +A + G+ ++P + E G
Sbjct: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
Query: 178 VCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNI 237
I P+NF + APAL GN V+ K ++ L++ + +++EAG PP ++
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 238 ITGYGPTAGAAIAQHVDVDKVAFTGSTEV-GHLIQKAAGDSN----LKRVTLELGGKSPS 292
+ GP G + + + FTGS HL ++ A + + R+ E GGK+
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 293 IVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPF 352
V AD+E V + F GQ C A SR +V S++ + R +E+ + KVG+P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 353 E-LDTQQGPQVDKEQFERVLGYIQLGQKE-GAKLLCGGERFGERGFFIKPTVFGGVQDDM 410
E T +D + F R+ +++ + +L GG+ G+F++P +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 411 RIAKEEIFGPVQPLF-----KFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQ- 464
I KEEIFGPV ++ K+K+ ++V+ + T YGL AVF++D D T+ L+
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
Query: 465 -AGTVWVN--TYNIVTCHTPFGGFKESGNGRELG 495
AG ++N + + PFGG + SG + G
Sbjct: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 139 bits (351), Expect = 5e-33
Identities = 119/454 (26%), Positives = 213/454 (46%), Gaps = 28/454 (6%)
Query: 62 GEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDR-VYLA 120
G + D++ +++A++AA A + W ++R ++ + AD++ R +
Sbjct: 28 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 84
Query: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK---TIPMDGQHFCFTRHEPVG 177
+ + GK ++ E+I +R+ A +A + G+ ++P + E G
Sbjct: 85 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 142
Query: 178 VCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNI 237
I P+NF + APAL GN V+ K ++ L++ + +++EAG PP ++
Sbjct: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
Query: 238 ITGYGPTAGAAIAQHVDVDKVAFTGSTEV-GHLIQKAAGDSN----LKRVTLELGGKSPS 292
+ GP G + + + FTGS HL ++ A + + R+ E GGK+
Sbjct: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
Query: 293 IVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPF 352
V AD+E V + F GQ C A SR +V S++ + R +E+ + KVG+P
Sbjct: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
Query: 353 E-LDTQQGPQVDKEQFERVLGYIQLGQKE-GAKLLCGGERFGERGFFIKPTVFGGVQDDM 410
E T +D + F R+ +++ + +L GG+ G+F++P +
Sbjct: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
Query: 411 RIAKEEIFGPVQPLF-----KFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQ- 464
I KEEIFGPV ++ K+K+ ++V+ + T YGL AVF++D D T+ L+
Sbjct: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 439
Query: 465 -AGTVWVN--TYNIVTCHTPFGGFKESGNGRELG 495
AG ++N + + PFGG + SG + G
Sbjct: 440 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 139 bits (351), Expect = 5e-33
Identities = 119/454 (26%), Positives = 213/454 (46%), Gaps = 28/454 (6%)
Query: 62 GEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDR-VYLA 120
G + D++ +++A++AA A + W ++R ++ + AD++ R +
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
Query: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK---TIPMDGQHFCFTRHEPVG 177
+ + GK ++ E+I +R+ A +A + G+ ++P + E G
Sbjct: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
Query: 178 VCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNI 237
I P+NF + APAL GN V+ K ++ L++ + +++EAG PP ++
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 238 ITGYGPTAGAAIAQHVDVDKVAFTGSTEV-GHLIQKAAGDSN----LKRVTLELGGKSPS 292
+ GP G + + + FTGS HL ++ A + + R+ E GGK+
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 293 IVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPF 352
V AD+E V + F GQ C A SR +V S++ + R +E+ + KVG+P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 353 E-LDTQQGPQVDKEQFERVLGYIQLGQKE-GAKLLCGGERFGERGFFIKPTVFGGVQDDM 410
E T +D + F R+ +++ + +L GG+ G+F++P +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 411 RIAKEEIFGPVQPLF-----KFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQ- 464
I KEEIFGPV ++ K+K+ ++V+ + T YGL AVF++D D T+ L+
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
Query: 465 -AGTVWVN--TYNIVTCHTPFGGFKESGNGRELG 495
AG ++N + + PFGG + SG + G
Sbjct: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 135 bits (339), Expect = 1e-31
Identities = 126/465 (27%), Positives = 197/465 (42%), Gaps = 76/465 (16%)
Query: 40 FINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDAS 99
++N +W + + P +P TGE + + DV AV+AAR AF+ W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
Query: 100 ERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK 159
R + L RLA+++++ + L +LE+L G+ +E D+ ++ Y A
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
Query: 160 TIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSAL 219
I Q EP+GV G I+P F + W++ PALA G TVV V +P + L
Sbjct: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APL 208
Query: 220 YLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVG--HLIQKAAGDS 277
LA L E G PG++N+++G +A + KVAF G+ E G LIQ++ D
Sbjct: 209 LLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVWDE 267
Query: 278 NLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLE 337
++R+ +G + + ++ AV+ G C + FV E+
Sbjct: 268 AMRRLQERMGR-----LRSGRGLDGAVDMGAR------GAAACDLVQRFVREA------- 309
Query: 338 RTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFF 397
QG QV + G+ ER F+
Sbjct: 310 ------------------QSQGAQVFQ----------------------AGDVPSERPFY 329
Query: 398 IKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAM 457
PT+ + A+ E+ PV F+ +E + AN T G +A+V++ L +A+
Sbjct: 330 -PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQAL 388
Query: 458 YFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAY 502
LQ GTVW+N + + P GG KESG G DGL Y
Sbjct: 389 ELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 433
Score = 88.2 bits (217), Expect = 2e-17
Identities = 92/293 (31%), Positives = 134/293 (45%), Gaps = 25/293 (8%)
Query: 7 PRLLSLQGRTARYSS-AAALPSPI-LNPDI------PYNQLFINNEWQDAVSKKTFPTVN 58
P LS + Y + A+PS + P+I PY LF+ +Q ++ + P +
Sbjct: 440 PARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYG-LFVGGRFQAPGARSSRP-IR 497
Query: 59 PTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVY 118
++G + G+VAEG D+ AV+AA +AF W R LL LA +ER +
Sbjct: 498 DSSGNLHGYVAEGGAKDIRGAVEAAHQAF---PGWAGQSPGARAALLWALAAALERRKST 554
Query: 119 LAS-LETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWH--GKTIPMDGQHFCFTR-HE 174
LAS LE G + + A EV R W + G T+ + G R E
Sbjct: 555 LASRLER--QGAELKAAEA----EVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLRE 608
Query: 175 PVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGV 234
P+GV + P +PL+ LAPALA GNTVVM + PL AL + + FP G+
Sbjct: 609 PLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGL 667
Query: 235 VNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELG 287
N++TG +A H DV + + GS + ++ A+ NLK V G
Sbjct: 668 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASA-GNLKPVWASRG 719
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 127 bits (318), Expect = 3e-29
Identities = 99/347 (28%), Positives = 157/347 (45%), Gaps = 19/347 (5%)
Query: 170 FTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAG 229
+ + +P+GV I WN+P V+ L A+A GN V++K +E + +A LA L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY- 154
Query: 230 FPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGK 289
+ +I G + Q D + +TG+T VG ++ +AA +L VTLELGGK
Sbjct: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGK 211
Query: 290 SPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVG 349
SP + D D++ + + N GQ C A E S+ N+ + + E K+ G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE-FYG 270
Query: 350 NPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDD 409
+ ++ F+R+L + EG K+ GGE E +I PTV V
Sbjct: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324
Query: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
++ +EEIFGP+ P+ K ++E + N LA VF+ + +G V
Sbjct: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV- 383
Query: 470 VNTYNIVTCH-----TPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 511
T N V H PFGG SG G G+ ++ + +K
Sbjct: 384 --TGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 127 bits (318), Expect = 3e-29
Identities = 99/347 (28%), Positives = 157/347 (45%), Gaps = 19/347 (5%)
Query: 170 FTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAG 229
+ + +P+GV I WN+P V+ L A+A GN V++K +E + +A LA L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY- 154
Query: 230 FPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGK 289
+ +I G + Q D + +TG+T VG ++ +AA +L VTLELGGK
Sbjct: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGK 211
Query: 290 SPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVG 349
SP + D D++ + + N GQ C A E S+ N+ + + E K+ G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE-FYG 270
Query: 350 NPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDD 409
+ ++ F+R+L + EG K+ GGE E +I PTV V
Sbjct: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324
Query: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
++ +EEIFGP+ P+ K ++E + N LA VF+ + +G V
Sbjct: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV- 383
Query: 470 VNTYNIVTCH-----TPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 511
T N V H PFGG SG G G+ ++ + +K
Sbjct: 384 --TGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 124 bits (310), Expect = 3e-28
Identities = 116/440 (26%), Positives = 180/440 (40%), Gaps = 20/440 (4%)
Query: 80 VKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQES----Y 135
++ REAF G R A R L L ++ ++ L D K ES
Sbjct: 8 LRRLREAFHAG---RTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEV 64
Query: 136 ALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWK 195
A+ EV R W F R EP G+ I PWN+PL +
Sbjct: 65 AISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVP 124
Query: 196 LAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDV 255
L ALA GN VV+K +E + LA ++ + ++ G GP + +H
Sbjct: 125 LVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQLLEH-RF 181
Query: 256 DKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNM 315
D + FTGS VG ++ AA +L VTLELGGK+P V + D + + +FN
Sbjct: 182 DYIFFTGSPRVGKIVMTAAA-KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
Query: 316 GQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQ 375
GQ C A + L ++ R G+ + G ++++QF+R+ +
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLG 299
Query: 376 LGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVE 435
G ++ GG+ E +I PTV VQ+ + +EEIFGP+ P+ + ++E +E
Sbjct: 300 CG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIE 353
Query: 436 RANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNT--YNIVTCHTPFGGFKESGNGRE 493
N LA F+ +G N ++ PFGG SG GR
Sbjct: 354 FINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRY 413
Query: 494 LGEDGLKAYTEVKTVTIKVP 513
G+ ++ + ++ P
Sbjct: 414 HGKFSFDTFSHHRACLLRSP 433
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 124 bits (310), Expect = 3e-28
Identities = 116/440 (26%), Positives = 180/440 (40%), Gaps = 20/440 (4%)
Query: 80 VKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQES----Y 135
++ REAF G R A R L L ++ ++ L D K ES
Sbjct: 8 LRRLREAFHAG---RTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEV 64
Query: 136 ALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWK 195
A+ EV R W F R EP G+ I PWN+PL +
Sbjct: 65 AISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVP 124
Query: 196 LAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDV 255
L ALA GN VV+K +E + LA ++ + ++ G GP + +H
Sbjct: 125 LVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQLLEH-RF 181
Query: 256 DKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNM 315
D + FTGS VG ++ AA +L VTLELGGK+P V + D + + +FN
Sbjct: 182 DYIFFTGSPRVGKIVMTAAA-KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
Query: 316 GQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQ 375
GQ C A + L ++ R G+ + G ++++QF+R+ +
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLG 299
Query: 376 LGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVE 435
G ++ GG+ E +I PTV VQ+ + +EEIFGP+ P+ + ++E +E
Sbjct: 300 CG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIE 353
Query: 436 RANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNT--YNIVTCHTPFGGFKESGNGRE 493
N LA F+ +G N ++ PFGG SG GR
Sbjct: 354 FINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRY 413
Query: 494 LGEDGLKAYTEVKTVTIKVP 513
G+ ++ + ++ P
Sbjct: 414 HGKFSFDTFSHHRACLLRSP 433
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 120 bits (302), Expect = 2e-27
Identities = 96/346 (27%), Positives = 153/346 (44%), Gaps = 13/346 (3%)
Query: 170 FTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAG 229
F R EP G+ I PWN+PL + L ALA GN VV+K +E + LA ++ +
Sbjct: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
Query: 230 FPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGK 289
++ G GP + +H D + FTGS VG ++ AA +L VTLELGGK
Sbjct: 121 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAA-KHLTPVTLELGGK 177
Query: 290 SPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVG 349
+P V + D + + +FN GQ C A + L ++ R G
Sbjct: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYG 236
Query: 350 NPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDD 409
+ + G ++++QF+R+ + G ++ GG+ E +I PTV VQ+
Sbjct: 237 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 290
Query: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
+ +EEIFGP+ P+ + ++E +E N LA F+ +G
Sbjct: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
Query: 470 VNT--YNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVP 513
N ++ PFGG SG GR G+ ++ + ++ P
Sbjct: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 119 bits (299), Expect = 5e-27
Identities = 96/341 (28%), Positives = 155/341 (45%), Gaps = 15/341 (4%)
Query: 170 FTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAG 229
F EP G+ I PWN+PL + L ALA G+ VV+K +E + + LA ++ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY- 76
Query: 230 FPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGK 289
++ G GP + +H +D + FTGS VG ++ AA +L VTLELGGK
Sbjct: 77 LDQSCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAA-TKHLTPVTLELGGK 133
Query: 290 SPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVG 349
+P V + D + + +FN GQ C A + L ++ R G
Sbjct: 134 NPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYG 192
Query: 350 NPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDD 409
+ + G ++++QF+R+ + G ++ GG+ E +I PTV VQ+
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-NESDRYIAPTVLVDVQET 246
Query: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
+ +EEIFGP+ P+ + ++E ++ N LA F+ + +G+
Sbjct: 247 EPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFG 306
Query: 470 VN---TYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKT 507
N TY I PFGG SG GR G+ ++ +T
Sbjct: 307 GNEGFTY-ISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,221,424
Number of Sequences: 37866
Number of extensions: 860193
Number of successful extensions: 1760
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1634
Number of HSP's gapped (non-prelim): 39
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.